CN114668826A - Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof - Google Patents

Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof Download PDF

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CN114668826A
CN114668826A CN202210331397.7A CN202210331397A CN114668826A CN 114668826 A CN114668826 A CN 114668826A CN 202210331397 A CN202210331397 A CN 202210331397A CN 114668826 A CN114668826 A CN 114668826A
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parts
solution
blood circulation
blood stasis
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李军民
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Ganzhou Baizhentang Flavor Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and a preparation method thereof, wherein the liquid comprises the following raw materials in parts by weight: 1-50 parts of safflower, 1-50 parts of pubescent holly root, 1-30 parts of turmeric root-tuber, 1-20 parts of notoginseng, 1-30 parts of hemlock parsley, 1-20 parts of turmeric, 1-50 parts of angelica and 1-5 parts of natural borneol. The invention is a natural plant formula, has no toxic or side effect and high safety, has the functions of promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain in the using process, and is further favorable for popularization and application.

Description

Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof
Technical Field
The invention relates to the technical field of pain treatment, in particular to a liquid capable of promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain and a preparation method thereof.
Background
Traumatic injury, sprain, strain, swelling and pain caused by the injury are common diseases in life, each disease usually needs at least more than one different medicine in treatment, the use is not very convenient, and part of the medicines have poor treatment effect and slow effect and have certain adverse reaction in the use process. Therefore, the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain and the preparation method thereof are provided.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a blood-activating, blood-stasis-removing, tendon-relaxing and pain-relieving liquid and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the liquid for promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain comprises the following raw materials in parts by weight: 1-50 parts of safflower, 1-50 parts of pubescent holly root, 1-30 parts of turmeric root-tuber, 1-20 parts of notoginseng, 1-30 parts of hemlock parsley, 1-20 parts of turmeric, 1-50 parts of angelica and 1-5 parts of natural borneol.
A preparation method of the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain comprises the following steps:
s1: selecting raw materials of safflower, pubescent holly root, turmeric root-tuber, pseudo-ginseng, szechuan lovage rhizome, turmeric and Chinese angelica according to certain weight parts, crushing the raw materials into 20-40 meshes by using a crusher, adding an ethanol solution which is 10-12 times of the weight of the raw materials, and extracting for 1-2 times under the ultrasonic condition to obtain an extracting solution;
s2, aiming at the obtained extracting solution, filtering impurities in the extracting solution by adopting a 1um-10um filter membrane to obtain a filtrate;
s3: adding propylene glycol into the obtained filtrate, mixing, pouring into a rotary evaporator, and performing vacuum concentration at 60-80 ℃ to recover ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, sterilizing at 90-100 deg.C for 20-30 min, and adding a certain amount of Borneolum Syntheticum after sterilization to obtain the final product.
Preferably, in step S1, the concentration of the ethanol solution is 50% to 70%.
Preferably, in the step S1, the single ultrasound extraction time lasts for 45-60 minutes.
Preferably, when the ultrasonic extraction is performed for 2 times in step S1, the extract is poured out after the first extraction is completed, an ethanol solution 10-12 times the weight of the raw material is added for the second extraction under the ultrasonic condition, and the two obtained extracts are combined before step S2 is started.
Preferably, in step S3, the propylene glycol is added in an amount of 50% to 70% by volume of the filtrate.
Preferably, in step S4, the 1, 2-hexanediol is added in an amount of 1% to 2% by volume of the concentrate.
The blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and the preparation method thereof provided by the invention have the beneficial effects that: according to the scheme, the safflower, the pubescent holly root, the curcuma tuber, the pseudo-ginseng, the szechuan lovage rhizome, the turmeric, the Chinese angelica and the natural borneol are all natural plants, so that the scheme is a natural plant formula, has no toxic or side effect and high safety, combines the drug properties of the safflower, the pubescent holly root, the curcuma tuber, the pseudo-ginseng, the ligusticum wallichii, the turmeric, the Chinese angelica and the natural borneol, has the effects of promoting blood circulation to remove blood stasis and relaxing muscles and tendons to relieve pain in the using process, and is favorable for popularization and application.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The liquid for promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain comprises the following raw materials in parts by weight: 1 part of safflower, 1 part of pubescent holly root, 1 part of turmeric root-tuber, 1 part of notoginseng, 1 part of hemlock parsley, 1 part of turmeric, 1 part of angelica and 1 part of natural borneol.
Aiming at the raw materials in parts by weight, the preparation of the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain is carried out by the following steps
S1: selecting raw materials of safflower, pubescent holly root, turmeric root-tuber, pseudo-ginseng, szechuan lovage rhizome, turmeric and Chinese angelica according to certain weight parts, crushing the raw materials into 20 meshes by using a crusher, adding an ethanol solution which is 10 times of the weight of the raw materials, and extracting for 1 time under the ultrasonic condition to obtain an extracting solution;
s2, aiming at the obtained extracting solution, filtering impurities in the extracting solution by adopting a 1um filter membrane to obtain a filtrate;
s3: adding propylene glycol into the obtained filtrate, mixing, pouring the mixture into a rotary evaporator, and performing vacuum concentration at 60 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, sterilizing at 90 ℃ for 20 minutes, and adding borneol into the concentrated solution after sterilization is finished to obtain the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain.
In step S1, the concentration of the ethanol solution is 50%.
In step S1, the ultrasound extraction time lasts 60 minutes.
In step S3, propylene glycol was added in an amount of 50% by volume of the filtrate.
In step S4, 1, 2-hexanediol was added in an amount of 1% by volume based on the volume of the concentrate.
Example 2
The liquid for promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain comprises the following raw materials in parts by weight: 25 parts of safflower, 25 parts of pubescent holly root, 15 parts of turmeric root-tuber, 10 parts of notoginseng, 30 parts of hemlock parsley, 20 parts of turmeric, 50 parts of angelica and 5 parts of natural borneol.
Aiming at the raw materials in parts by weight, the preparation of the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain is carried out by the following steps
S1: selecting raw materials of safflower, pubescent holly root, turmeric root-tuber, pseudo-ginseng, szechuan lovage rhizome, turmeric and Chinese angelica according to certain weight parts, crushing the raw materials into 30 meshes by using a crusher, adding an ethanol solution which is 11 times of the weight of the raw materials, and extracting for 2 times under the ultrasonic condition to obtain an extracting solution;
s2, aiming at the obtained extracting solution, filtering impurities in the extracting solution by adopting a 5um filter membrane to obtain a filtrate;
s3: adding propylene glycol into the obtained filtrate, mixing, pouring into a rotary evaporator, and performing vacuum concentration at 70 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, sterilizing at 95 ℃ for 25 minutes, and adding borneol into the concentrated solution after sterilization is finished to obtain the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain.
In step S1, the concentration of the ethanol solution is 60%.
In step S1, a single ultrasound extraction time lasts 55 minutes.
The second ultrasonic extraction in the step S1 is to pour out the extract after the first extraction is completed, add an ethanol solution 11 times the weight of the raw materials to perform the second extraction under the ultrasonic condition, and combine the two obtained extracts before the step S2 is started.
In step S3, propylene glycol was added in an amount of 60% by volume of the filtrate.
In step S4, 1, 2-hexanediol was added in an amount of 1.5% by volume based on the volume of the concentrate.
Example 3
The liquid for promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain comprises the following raw materials in parts by weight: 50 parts of safflower, 50 parts of pubescent holly root, 30 parts of turmeric root-tuber, 20 parts of pseudo-ginseng, 15 parts of szechuan lovage rhizome, 10 parts of turmeric, 25 parts of Chinese angelica and 3 parts of natural borneol.
Aiming at the raw materials in parts by weight, the preparation of the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain is carried out by the following steps
S1: selecting raw materials of safflower, pubescent holly root, turmeric root-tuber, pseudo-ginseng, szechuan lovage rhizome, turmeric and Chinese angelica according to certain weight parts, crushing the raw materials into 40 meshes by using a crusher, adding an ethanol solution with the weight 12 times that of the raw materials, and extracting the mixture 1 under the ultrasonic condition to obtain an extracting solution;
s2, filtering impurities in the extracting solution by adopting a 10um filter membrane aiming at the obtained extracting solution, and obtaining filtrate;
s3: adding propylene glycol into the obtained filtrate, mixing, pouring into a rotary evaporator, and performing vacuum concentration at 80 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, sterilizing at 100 ℃ for 30 minutes, and adding a certain amount of borneol into the concentrated solution after sterilization is finished to obtain the liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain.
In step S1, the concentration of the ethanol solution is 70%.
In step S1, a single ultrasound extraction time lasts 60 minutes.
In step S3, propylene glycol was added in an amount of 70% by volume of the filtrate.
In step S4, 1, 2-hexanediol was added in an amount of 2% by volume based on the volume of the concentrate.
Comparative example:
the blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid obtained in the embodiment 1, the embodiment 2 and the embodiment 3 is selected and respectively used for three groups of patients with swelling and pain caused by traumatic injury, sprain and strain, and the blood circulation promoting and pain relieving capsule on the market is selected and used for the patients with swelling and pain caused by traumatic injury, sprain, strain, wherein the application process is 3 times a day and lasts for seven days, and the statistics of the treatment effects (the treatment effects are divided into ineffectiveness, effectiveness and cure) are shown in the following table 1:
Figure BDA0003575181380000061
according to the table 1, it can be seen that the blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid of the present invention has the advantages of fast effect, fast treatment and recovery of patients when applied to injuries from falls, sprains, strains and pains caused by injuries, and in combination with the scheme, the safflower, the pubescent holly root, the turmeric root-tuber, the pseudo-ginseng, the szechuan lovage rhizome, the turmeric, the Chinese angelica and the natural borneol are all natural plants, so the liquid is a natural plant formula, has no toxic or side effect, high safety and is favorable for popularization and use.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is specific and detailed, but not construed as limiting the patent of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the spirit of the invention, which falls within the scope of the invention.

Claims (7)

1. The liquid for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and relieving pain is characterized by comprising the following raw materials in parts by weight: 1-50 parts of safflower, 1-50 parts of pubescent holly root, 1-30 parts of turmeric root-tuber, 1-20 parts of notoginseng, 1-30 parts of hemlock parsley, 1-20 parts of turmeric, 1-50 parts of angelica and 1-5 parts of natural borneol.
2. The method for preparing the liquid for promoting blood circulation by removing blood stasis, relaxing muscles and tendons and relieving pain as claimed in claim 1, comprising the steps of:
s1: selecting raw materials of safflower, pubescent holly root, turmeric root-tuber, pseudo-ginseng, szechuan lovage rhizome, turmeric and Chinese angelica according to certain weight parts, crushing the raw materials into 20-40 meshes by using a crusher, adding an ethanol solution which is 10-12 times of the weight of the raw materials, and extracting for 1-2 times under the ultrasonic condition to obtain an extracting solution;
s2, aiming at the obtained extracting solution, filtering impurities in the extracting solution by adopting a 1um-10um filter membrane to obtain a filtrate;
s3: adding propylene glycol into the obtained filtrate, mixing, pouring into a rotary evaporator, and performing vacuum concentration at 60-80 ℃ to recover ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, sterilizing at 90-100 deg.C for 20-30 min, and adding a certain amount of Borneolum Syntheticum after sterilization to obtain the final product.
3. The method for preparing the solution for promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain of claim 2, wherein in the step S1, the concentration of the ethanol solution is 50% -70%.
4. The method as claimed in claim 2, wherein in step S1, the single ultrasonic extraction lasts 45-60 minutes.
5. The method of claim 2, wherein in step S1, when the ultrasonic extraction is performed 2 times, the extract is poured out after the first extraction is completed, an ethanol solution 10-12 times of the weight of the raw materials is added to perform the second extraction under the ultrasonic condition, and the two obtained extracts are combined before step S2 is performed.
6. The method for preparing the solution for promoting blood circulation to remove blood stasis, relaxing muscles and tendons and relieving pain as claimed in claim 2, wherein in step S3, the addition amount of propylene glycol is 50% -70% of the volume of the filtrate.
7. The method for preparing the solution for promoting blood circulation, removing blood stasis, relaxing muscles and tendons, and relieving pain as claimed in claim 2, wherein in step S4, the addition amount of 1, 2-hexanediol is 1% -2% of the volume of the concentrated solution.
CN202210331397.7A 2022-03-31 2022-03-31 Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof Pending CN114668826A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101940731A (en) * 2009-07-08 2011-01-12 周恒根 Pseudo-ginseng formula for promoting blood circulation and relieving pain
CN103933300A (en) * 2014-02-11 2014-07-23 庞良智 Traditional Chinese medicine capable of relieving pain and invigorating blood circulation, and preparation method thereof
CN104116771A (en) * 2014-07-24 2014-10-29 北京康远制药有限公司 Red tablets with effect of promoting blood circulation and stopping pain and preparation method of red tablets
CN110538279A (en) * 2019-09-10 2019-12-06 杨环宇 External traditional Chinese medicine and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101940731A (en) * 2009-07-08 2011-01-12 周恒根 Pseudo-ginseng formula for promoting blood circulation and relieving pain
CN103933300A (en) * 2014-02-11 2014-07-23 庞良智 Traditional Chinese medicine capable of relieving pain and invigorating blood circulation, and preparation method thereof
CN104116771A (en) * 2014-07-24 2014-10-29 北京康远制药有限公司 Red tablets with effect of promoting blood circulation and stopping pain and preparation method of red tablets
CN110538279A (en) * 2019-09-10 2019-12-06 杨环宇 External traditional Chinese medicine and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李莉;: "高效液相色谱法测定红药片中欧前胡素和异欧前胡素的含量", 中华中医药学刊, vol. 28, no. 09, 10 September 2010 (2010-09-10), pages 1991 *
王敏;马玉梅;: "HPLC法测定跌打红药片人参皂苷Rg_1、Rb_1及三七皂苷R_1的含量", 中国民族民间医药, no. 23, 15 December 2012 (2012-12-15), pages 29 *

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