CN102178828B - Medicament for treating proliferation of mammary gland and preparation method thereof - Google Patents
Medicament for treating proliferation of mammary gland and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating proliferation of mammary gland and a preparation method thereof, wherein the medicament comprises the following Chinese medicinal herbs of red-rooted salvia root, nutgrass galingale rhizome, pericarpium citri reticulatae viride, szechuan lovage rhizome, Chinese thorowax root, common selfheal fruitspike, thunberg fritillary bulb, seaweed, calcined concha arcae and dextrin. The preparation method comprises the steps of: mixing the red-rooted salvia root with the nutgrass galingale rhizome, and then adding alcohol for extracting twice; filtering, and then merging two filtrates to obtain an alcohol extract; mixing the pericarpium citri reticulatae viride, the szechuan lovage rhizome and the Chinese thorowax root, and then adding water for distilling to extract essential oil, collecting the essential oil for later use, filtering residual materials for collecting filter residue; and mixing the filter residue with the common selfheal fruitspike, the thunberg fritillary bulb, the seaweed and the calcined concha arcae, and then decocting, filtering, concentrating and drying to obtain the medicament. The medicament has functions of soothing liver, regulating vital energy and resolving hard lump, and can be used for treating proliferation of mammary gland.
Description
One, technical field
The present invention relates to a kind of medicine and preparation method thereof, specifically a kind of medicine of treating cyclomastopathy and preparation method thereof belongs to the field of Chinese medicines.
Two, background skill
Cyclomastopathy (Hyperplasia of mammary gland; HMG) be the benign proliferative diseases of mammary gland tissue; Be a mammary gland parenchyma and a matter to some extent the breast structure due to hypertrophy and the subinvolution in quantity and modal unusual; The palp lump of normal formation, neither tumor, also non-inflammation.Primary disease is women's at reproduction age commonly encountered diseases and a frequently-occurring disease, and its sickness rate accounts for the women of child-bearing age's about 47%, accounts for 75% of whole mastopathy, is modal cystic hyperplasia of breast.At present, China more than 30 years old women's sickness rate account for 30-50%, be most commonly in the 30-50 women in year, certain carcinogenic tendency is arranged.Along with the quickening of social life rhythm, the development of cyclomastopathy is in rising trend in recent years, and at present clinical still do not have the definite effective Therapeutic Method to cyclomastopathy.
The pathogenesis of cyclomastopathy is still not fully aware of at present; Modern medicine study thinks, cyclomastopathy be because endocrine dysfunction, ovarian dysfunction; Be that progesterone level reduces in the body; Estrogen relatively or absolute too high and cause mammary gland in the hyperplasia in menstrual period, through after meromorphosis, thereby cause breast duct, lobule or phorocytosis on every side.In addition, the patient receives the stimulation of Nervous and Mental Factors, fatigue, work strain repeatedly, and these bad Nervous and Mental Factors often act on cerebral cortex; So that it gets muddled to hypothalamic adjusting, and the gonadotropin releasing hormone that the hypothalamus secretion is excessive acts on hypophysis cerebri; Make flitropin and interstitialcellstimulating hormone (ICSH) secretion increasing; Causing blood plasma E, raise and progesterone concentration reduces relatively, also is to impel mammary gland acinus and glandular tube hypertrophy and the main cause of falling ill.
In the last few years, doctor trained in Western medicine was being explored the cause of disease and the Therapeutic Method of HMG always, and western medical treatment has two kinds of methods clinically: (1) pharmacotherapy: normally used Western medicine has two types: hormone medicine and vitamin medicaments.Though hormone medicine has certain therapeutical effect to primary disease, side effect is in various degree arranged also.It mainly is the balance of disturbing between the human hormone.Vitamin medicaments has vitamin E, vitamin A etc., but at present, the curative effect of vitamin is still disputable, and vitamin A etc. for a long time clothes a lot of untoward reaction can appear.(2) operative treatment: operative treatment is applicable to that mainly the hypertrophy pathological changes is more serious, the lump hardening, or biopsy discovery epithelial hyperplasia is remarkable, is special-shaped person.Though operative treatment has certain curative effect, but postoperative infection, certain risk is all arranged after more.For Most patients, still select side effect little, eutherapeutic therapeutic scheme.In a word, symptom is just alleviated or improved to the western medical treatment primary disease how, and side effect is big, and is disorderly more with it improper hormone in vivo balance that instead can make, and is difficult to make the Histological change after the cyclomastopathy to obtain restoring.Therefore, searching determined curative effect, taking convenience, little this disease of treatment by Chinese herbs of side effect become the task of top priority.
HMG belongs to the traditional Chinese medical science " nodules of the breast ", " newborn painful abdominal mass " reaches categories such as " nodule in the breasts ".Motherland's medical science is thought the liver failing to maintain the normal flow of QI, Chong and Ren channel disorder and to cause QI-blood circulation not smooth, and qi depression to blood stasis, expectorant condenses to gather and forms nodules of the breast." Waike Zhengzong, Orthodox Manual of External Diseases " of bright Chen Shigong done detailed description to nodules of the breast, as " nodules of the breast is a nodule in the breast, shape such as ball ovum, or weigh down the recast pain, or not bitterly, color of the leather is constant, and it is examined with the susceptible to anger growth and decline ... ".Qi depression to blood stasis is the key link that primary disease takes place.
It is main method with blood circulation promoting and blood stasis dispelling, hard masses softening and resolving that the traditional Chinese medical science is treated cyclomastopathy many at present, and relatively the QI stagnated by cold person then helps with dispelling cold by warming the meridian, and the person that belongs to the stagnation of QI due to depression of the liver is aided with soothing liver-QI for relieving depression.The used square medicine specific aim of its treatment is not strong, and curative effect is all not so good.
Three, summary of the invention
The present invention is for fear of above-mentioned existing in prior technology weak point, and medicine of a kind of treatment cyclomastopathy with strong points, eutherapeutic and preparation method thereof is provided.
Technical solution problem of the present invention adopts following technical scheme:
A kind of characteristics of treating the medicine of cyclomastopathy of the present invention are to constitute by its crude drug of mass fraction:
Radix Salviae Miltiorrhizae 2-6 part, Rhizoma Cyperi 3-7 part, Pericarpium Citri Reticulatae Viride 3-7 part, Rhizoma Chuanxiong 1-5 part, Radix Bupleuri 2-6 part, Spica Prunellae 4-8 part, Bulbus Fritillariae Thunbergii 3-7 part, Sargassum 4-8 part, Concha Arcae (calcined) 5-9 part;
A kind of characteristics of treating the medicine of cyclomastopathy of the present invention are to constitute by its crude drug of mass fraction:
4.5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Cyperis, 5 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Rhizoma Chuanxiongs, 4.5 parts of Radix Bupleuri, 6 parts of Spica Prunellaes, 5 parts of Bulbus Fritillariae Thunbergiis, 6 parts of Sargassums, 7.5 parts of Concha Arcae (calcined);
The characteristics of method for preparing that the present invention treats the medicine of cyclomastopathy are to operate according to the following steps:
A, add ethanol extraction twice after Radix Salviae Miltiorrhizae and Rhizoma Cyperi mixed, filter the back merge filtrate for twice alcohol extract;
B, add water distillation and extraction volatile oil after Pericarpium Citri Reticulatae Viride, Rhizoma Chuanxiong and Radix Bupleuri mixed, it is subsequent use to collect volatile oil, and clout filters collects filtering residue;
C, the filtering residue that obtains among the step b is mixed with Spica Prunellae, Bulbus Fritillariae Thunbergii, Sargassum and Concha Arcae (calcined) and decocte with water twice, filters the back and merge twice decocting liquid, in 100 ℃ be concentrated into relative density 1.12 concentrated solution; In said concentrated solution, add ethanol, make that alcoholic acid mass percent is 60-70%, staticly settled 10-12 hour; Filter and collect filtrating, said filtrating and said alcohol extract are merged, distilling under reduced pressure is concentrated into thick paste with remaining liquid in 100 ℃ after removing ethanol; Said thick paste is dry, pulverizing back is crossed 80 mesh sieves and is got dry extract; In said dried cream, add dextrin, the addition of dextrin is 1.5 times of dried cream quality, processes granule behind the mix homogeneously; 60 ℃ after dry 2-4 hour to the said volatile oil of the particulate surface sprinkling of gained, get product after airtight preservation 24-36 hour.
In the compatibility of the present invention:
Pericarpium Citri Reticulatae Viride is rutaceae orange and the young fruit of plantation mutation or the peel of immature fruit, and bitter in the mouth, suffering are warm in nature.Return liver, gallbladder, stomach warp.Sedimentation is descending, is good at unclogging and readjusting the gas that stagnates of liver and gall, because of distending pain of the breast or the caking due to the stagnation of QI, and can be singly with this article decoction.
Radix Bupleuri bitter in the mouth, suffering, cold nature.Go into liver, gallbladder meridian.Dry root for umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Effect with reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.
Pericarpium Citri Reticulatae Viride and Radix Bupleuri two medicines mutually 5 bring out the best in each other, and are used for the primary symptom of mastalgia due to the cyclomastopathy (stagnation of QI due to depression of the liver), lump in breast companion breast side of body feeling of distension and oppression, the merit of long memorial liver and qi altogether, and treatment caused by hepatic stagnation qi stagnation cyclomastopathy is we's monarch drug altogether.
Rhizoma Cyperi acrid in the mouth, little hardship, sweet, property is flat.Go into liver, tri-jiao channel.Be sedge dried tuber rhizome.Effect with the resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Be used for incoordination between the liver and stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness.
Spica Prunellae bitter in the mouth, suffering, cold in nature.Fruit ear for the labiate Spica Prunellae.Effect with clearing away liver-fire, Disperse hepatic depression, blood pressure lowering.
Rhizoma Cyperi and Spica Prunellae two medicines are played the merit of resolving depression pathogenic fire purging, depressed liver-energy dispersing and QI regulating altogether.
Bulbus Fritillariae Thunbergii is liliaceous plant Bulbus Fritillariae Thunbergii bitter in the mouth, and is cold in nature.Go into lung, stomach, liver, tri-jiao channel.Effect with removing heat-phlegm, eliminating stagnation.
Sargassum bitter in the mouth, salty, cold in nature.Return liver, stomach, kidney channel.Effect with hard masses softening and resolving, expectorant, diuretic.Be used for goiter, scrofula, painful and swollen testis, phlegm retention edema.
The merit that Bulbus Fritillariae Thunbergii and Sargassum two medicines are played hard masses softening and resolving altogether.
Rhizoma Cyperi, Spica Prunellae, Bulbus Fritillariae Thunbergii and Sargassum four Chinese medicine, mutually 5 and close, auxiliary monarch drug is strengthened treatment main cause and primary symptom, with the prestige of auxiliary monarch drug, is we's ministerial drug.
The Rhizoma Chuanxiong acrid in the mouth, warm in nature.Go into liver, gallbladder meridian.Be samphire Rhizoma Chuanxiong rhizome.Effect with activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.Be used for diseases such as air-cooled headache, hypochondriac pain abdomen are painful, arthralgia due to cold clonic spasm of the muscle.
The Concha Arcae (calcined) salty in the mouth, property is hot, and is nontoxic.Go into lung, stomach, Liver Channel.Can hard masses softening and resolving, expectorant silts of dispelling, promoting blood circulation and stopping pain can the eliminating stagnation piece, eliminating mass knot, treatment mass in the abdomen.
The Radix Salviae Miltiorrhizae bitter in the mouth, cold nature.Go into the heart, Liver Channel.Root for the labiate Radix Salviae Miltiorrhizae.Effect with activating blood and removing stasis, removing heat from blood eliminating carbuncle, pain relieving.
Rhizoma Chuanxiong, Concha Arcae (calcined) and Radix Salviae Miltiorrhizae three flavor medicines, to assist the medicinal of monarch, minister, all medicines are adjuvant among the we to reach focus altogether in the side of drawing.
All medicines are harmonious, altogether the effect of long memorial liver and qi, hard masses softening and resolving.Mastalgia, all diseases of lump in breast companion breast side of body feeling of distension and oppression are worked as spontaneous recovery due to the cyclomastopathy (stagnation of QI due to depression of the liver).Medicine of the present invention should be taken after mixing it with water, every day three times, each ten grams.
Below further specify the beneficial effect of medicine of the present invention through the pharmacodynamics test of medicine of the present invention.
The influence of the rat mammary gland model of hyperplasia that estradiol is caused
Be equivalent to clinical consumption with medicine of the present invention, irritate stomach and give rat after 30 days, the rat mammary gland hypertrophy that estradiol is caused has the significant protection effect, through statistical analysis:
1, medicine of the present invention is to the exponential influence of hyperplasia of mammary gland model rat uterus
Drug group of the present invention can significantly reduce hyperplasia of mammary gland model rat uterus index, relatively has extremely significantly meaning (P＜0.01) with model control group, and concrete experimental data is seen table 1.
Table 1 medicine is to the exponential influence in experimental animal uterus
Compare * * P＜0.01 with model control group; Compare △ △ P＜0.01 with blank control group.
2, medicine of the present invention is to the influence of hyperplasia of mammary gland model rat sex hormone level
Compare model group E with blank control group
2, PRL raise (P＜0.01).Compare drug group E of the present invention with model group
2, PRL reduces (P＜0.01 and P＜0.05), concrete experimental data is seen table 2.
Table 2 medicine is to the influence
of experimental animal gonadal hormone
Compare * P＜0.05, * * P＜0.01 with model control group; Compare with blank control group
△ △P＜0.01.
In sum, after medicine animal of the present invention is oral, can resist the rat mammary gland hypertrophy disease that causes because of estradiol, these article have the effect of certain treatment cyclomastopathy.
Compared with present technology, beneficial effect of the present invention is embodied in:
1, medicine of the present invention has the effect of depressed liver-energy dispersing and QI regulating, hard masses softening and resolving; The cause of disease, pathogenesis reason, clinical manifestation to the caused by hepatic stagnation qi stagnation cyclomastopathy; Mastalgia due to the cyclomastopathy (stagnation of QI due to depression of the liver), lump in breast companion breast side of body feeling of distension and oppression have been solved preferably; Irritated irritability, thin white fur of tongue, the problem of stringy pulse;
2, the present invention adopts modern crafts to extract effective ingredient, make medicine be prone to more dissolve, instant, and make the volume " traceization " of medicine, be easy to carry and store.
Four, the specific embodiment
Embodiment 1:
The medicine of treatment cyclomastopathy constitutes by its crude drug of mass fraction in the present embodiment:
2 parts of Radix Salviae Miltiorrhizaes, 3 parts of Rhizoma Cyperis, 3 parts on Pericarpium Citri Reticulatae Viride, 1 part of Rhizoma Chuanxiong, 2 parts of Radix Bupleuri, 4 parts of Spica Prunellaes, 3 parts of Bulbus Fritillariae Thunbergiis, 4 parts of Sargassums, 5 parts of Concha Arcae (calcined);
The medicine of treatment cyclomastopathy prepares according to the following steps in the present embodiment:
A, add ethanol extraction twice after Radix Salviae Miltiorrhizae and Rhizoma Cyperi mixed, filter the back merge filtrate for twice alcohol extract;
B, added water distillation and extraction volatile oil 5 hours after Pericarpium Citri Reticulatae Viride, Rhizoma Chuanxiong and Radix Bupleuri mixed, it is subsequent use to collect volatile oil, and clout filters collects filtering residue, and the addition of water is Pericarpium Citri Reticulatae Viride, Rhizoma Chuanxiong and Radix Bupleuri volume 12 times;
C, the filtering residue that obtains among the step b is mixed with Spica Prunellae, Bulbus Fritillariae Thunbergii, Sargassum and Concha Arcae (calcined) and decocte with water twice, each 2 hours, amount of water was filtering residue, Spica Prunellae, Bulbus Fritillariae Thunbergii, Sargassum and Concha Arcae (calcined) cumulative volume 10 times; Filter the back and merge twice decocting liquid, be concentrated into relative density 1.12 (80 ℃ of heat are surveyed) in 100 ℃ and get concentrated solution, in concentrated solution, add ethanol; Make that alcoholic acid mass percent is 60-70%, staticly settled 10-12 hour, filter and collect filtrating; To filtrate and the alcohol extract merging,, after ethanol is reclaimed in 60-80 ℃ of following distilling under reduced pressure remaining liquid will be concentrated into thick paste in 100 ℃ in 0.05-0.1MPa; Again in 0.05-0.1MPa, 60-80 ℃ dry 24-36 hour down, get dry extract after pulverizing 80 mesh sieves; Process granule after in dried cream, adding the dextrin mix homogeneously, the addition of dextrin is 1.5 times of dried cream quality, and 60 ℃ after dry 2-4 hour; To the particulate surface sprinkling volatile oil of gained, get product after airtight preservation 24-36 hour.
Medicine of the present invention should be taken after mixing it with water, every day three times, each ten grams.
Embodiment 2:
The medicine of treatment cyclomastopathy constitutes by its crude drug of mass fraction in the present embodiment:
4.5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Cyperis, 5 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Rhizoma Chuanxiongs, 4.5 parts of Radix Bupleuri, 6 parts of Spica Prunellaes, 5 parts of Bulbus Fritillariae Thunbergiis, 6 parts of Sargassums, 7.5 parts of Concha Arcae (calcined);
The method for preparing of the medicine of treatment cyclomastopathy is with embodiment 1 in the present embodiment.
Medicine of the present invention should be taken after mixing it with water, every day three times, each ten grams.
Embodiment 3:
The medicine of treatment cyclomastopathy constitutes by its crude drug of mass fraction in the present embodiment:
6 parts of Radix Salviae Miltiorrhizaes, 7 parts of Rhizoma Cyperis, 7 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Rhizoma Chuanxiongs, 6 parts of Radix Bupleuri, 8 parts of Spica Prunellaes, 7 parts of Bulbus Fritillariae Thunbergiis, 8 parts of Sargassums, 9 parts of Concha Arcae (calcined);
The method for preparing of the medicine of treatment cyclomastopathy is with embodiment 1 in the present embodiment.
Medicine of the present invention should be taken after mixing it with water, every day three times, each ten grams.
Above various embodiment all is a basically identical to hyperplasia of mammary gland model rat therapeutic effect.
Claims (3)
1. medicine of treating cyclomastopathy is characterized in that constituting by its crude drug of mass fraction:
Radix Salviae Miltiorrhizae 2-6 part, Rhizoma Cyperi 3-7 part, Pericarpium Citri Reticulatae Viride 3-7 part, Rhizoma Chuanxiong 1-5 part, Radix Bupleuri 2-6 part, Spica Prunellae 4-8 part, Bulbus Fritillariae Thunbergii 3-7 part, Sargassum 4-8 part, Concha Arcae (calcined) 5-9 part.
2. medicine according to claim 1 is characterized in that constituting by its crude drug of mass fraction:
4.5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Cyperis, 5 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Rhizoma Chuanxiongs, 4.5 parts of Radix Bupleuri, 6 parts of Spica Prunellaes, 5 parts of Bulbus Fritillariae Thunbergiis, 6 parts of Sargassums, 7.5 parts of Concha Arcae (calcined).
3. the method for preparing of the medicine of treatment cyclomastopathy as claimed in claim 1 is characterized in that operating according to the following steps:
A, add ethanol extraction twice after Radix Salviae Miltiorrhizae and Rhizoma Cyperi mixed, filter the back merge filtrate for twice alcohol extract;
B, add water distillation and extraction volatile oil after Pericarpium Citri Reticulatae Viride, Rhizoma Chuanxiong and Radix Bupleuri mixed, it is subsequent use to collect volatile oil, and clout filters collects filtering residue;
C, the filtering residue that obtains among the step b is mixed with Spica Prunellae, Bulbus Fritillariae Thunbergii, Sargassum and Concha Arcae (calcined) and decocte with water twice, filters the back and merge twice decocting liquid, in 100 ℃ be concentrated into relative density 1.12 concentrated solution; In said concentrated solution, add ethanol, make that alcoholic acid mass percent is 60-70%, staticly settled 10-12 hour; Filter and collect filtrating, said filtrating and said alcohol extract are merged, distilling under reduced pressure is concentrated into thick paste with remaining liquid in 100 ℃ after removing ethanol; Said thick paste is dry, pulverizing back is crossed 80 mesh sieves and is got dry extract; In said dried cream, add dextrin, the addition of dextrin is 1.5 times of dried cream quality, processes granule behind the mix homogeneously; 60 ℃ after dry 2-4 hour to the said volatile oil of the particulate surface sprinkling of gained, get product after airtight preservation 24-36 hour.
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Families Citing this family (5)
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| CN102688374B (en) * | 2012-06-07 | 2013-12-11 | 山西省中医药研究院 | Medicament for treating hyperplasia of mammary glands |
| CN104043046A (en) * | 2014-06-23 | 2014-09-17 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine for treating hepatic depression syndrome type breast distending pain during menstruation |
| CN104606605A (en) * | 2015-03-06 | 2015-05-13 | 宋辉 | Traditional Chinese medicine composition for treating breast hyperplasia and preparation method for traditional Chinese medicine composition |
| CN104815148B (en) * | 2015-04-27 | 2018-08-21 | 吴联合 | A kind of pharmaceutical composition for treating the proliferation of mammary gland |
| CN109078154A (en) * | 2018-10-31 | 2018-12-25 | 中山市六安堂健康管理有限公司 | A kind of pharmaceutical composition and its preparation method and application for treating the proliferation of mammary gland |
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| CN101049465A (en) * | 2007-01-26 | 2007-10-10 | 郭晓华 | Capsule of Chinese traditional medicine for treating cyclomastopathy |
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| CN1692933A (en) * | 2005-04-15 | 2005-11-09 | 扬子江药业集团有限公司 | Compound traditional Chinese medicine for treating proliferation of mammary gland, and its prepn. method |
| CN101049465A (en) * | 2007-01-26 | 2007-10-10 | 郭晓华 | Capsule of Chinese traditional medicine for treating cyclomastopathy |
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