CN104208418A

CN104208418A - Rosa laevigata michx health oral solution for securing essence, reducing urination and tonifying kidneys and preparation method thereof

Info

Publication number: CN104208418A
Application number: CN201410424187.8A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2014-08-26
Filing date: 2014-08-26
Publication date: 2014-12-17

Abstract

The invention discloses a rosa laevigata michx health oral solution for securing essence, reducing urination and tonifying kidneys. The health oral solution is prepared from the following medicinal raw materials in parts by weight: 10-50 parts of rosa laevigata michx, 10-20 parts of rhizoma cibotii, 10-20 parts of glossy privet fruit, 10-20 parts of epimedium, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of fructus psoraleae, 10-20 parts of radix rehmanniae praeparata, 10-20 parts of semen cuscutae, 10-20 parts of notopterygium root, 10-20 parts of cornus officinalis, 10-20 parts of sealwort, 10-20 parts of herba taxilli, 10-20 parts of poria cocos, 10-20 parts of radix paeoniae rubra, 10-20 parts of schisandra chinensis and 10-20 parts of fructus rubi, wherein rosa laevigata michx has a unique flavor and contains citric acid, malic acid, vitamin C, saponins and lots of saccharides. To overcome the technical defects in the prior art, the traditional Chinese medicinal materials with effects of reinforcing kidneys to strengthen yang, nourishing essence and blood, strengthening tendons and bones are selected to prepare the health oral solution, and most of the traditional Chinese medicinal materials taste fresh and light and have remarkable drug effect. The rosa laevigata michx health oral solution can be used for a long time and easily accepted by people, and can achieve the effects of strengthening body, enriching yin, nourishing kidneys, strengthening tendons and muscles and tonifying yang-qi.

Description

Fructus Rosae Laevigatae health care oral liquid of a kind of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating and preparation method thereof

Technical field

The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, particularly a kind of Fructus Rosae Laevigatae health care oral liquid and preparation method thereof of controlling nocturnal emission with astringent drugs reducing urination.

Background technology

Kidney hides first acquired essence, and kidney essense turns to kidney qi, wherein to body have warm, excite, excited, evaporate, seal and hide and restrict the actor such as YIN-cold and be referred to as kidney yang, be also called Yuanyang, kidney-Yang, kidney-yang; To body have moist, quiet, be shaped and suppress the excessively actor such as sun heat to be referred to as kidney yin, be also called Kidney-Yin, Kidney-Yin, true water.Kidney yang can promote metabolism and the gasification of human body, and promote that the change of essence and blood body fluid is given birth to and makes it to be converted into energy, make the progress faster of the various physiological activity of human body, heat production increases, in high spirits; Kidney yin then suppresses or the excessive metabolic processes of reducing human, make essence and blood body fluid be converted into energy to reduce, the process of the various physiological activity of human body slows down, heat production reduces relatively, and make gas be polymerized to shape and be essence and blood body fluid, spirit be also tending towards quiet in keep the two and oppose each other and yet also complement each other, common regulable control the function activity of human body and the metabolic process of essence and blood body fluid.

According to the yin-yang theory of Chinese medicine, negative and positive have limitlessly detachable, and kidney hides first acquired essence, and essence belongs to cloudy, so claim cloudy essence, QI belonging to YANG, so claim yang-energy, are collectively referred to as cloudy the vivid YANG QI.Kidney essense belongs to cloudy essence, again can forked rubbing again among cloudy essence, wherein can be divided into again cloudy smart the yang aspect of yang essence and the moon essence the yin aspect of yin smart.When cloudy smart the yang aspect of yang damage of essence is empty, has soreness of waist and knee joint, nocturia, spinal column to wither the Symptoms such as sour tired out, the fatiguability of weak, bone, have soreness of the waist and knees, talalgia, dry mouth and tougue when cloudy smart the yin aspect of yin damage of essence is empty, quench one's thirst, the Symptoms such as insomnia and dreamful sleep.How in close relations with insufficiency of kidney-YANG when cloudy smart the yang aspect of yang damage of essence is empty, how in close relations with deficiency of the kidney yin when cloudy smart the yin aspect of yin damage of essence is empty.So during insufficiency of kidney-YANG except the performance such as have fear of cold to be afraid of cold the normal symptoms such as sour tired out, the fatiguability of weak, bone of withering with soreness of waist and knee joint, spinal column, normal except the performance such as have the deficiency of YIN scorching during deficiency of the kidney yin is soreness of waist and knee joint with soreness of the waist and knees, talalgia, dry mouth and tougue, the symptom clinical manifestation such as to quench one's thirst, aversion to cold and cold limbs, especially be very with lower limb, the vertigo, lethargy, pale complexion; Or dark, the fat tongue of light red tongue is white, deep and weak pulse; Sexual impotence, premature ejaculation, women's infertility, or stool chronic diarrhea is more than, aqueous-grainy diarrhea, Diarrhoea; Or edema, be very below waist, by depression do not rise, very then abdominal part distending pain, cardiopalmus cough with asthma.So when kidney-replenishing, must tonifying kidney-yin, and want treating YANG within YIN, and when tonifying kidney-yin neither simply only with the medicine of tonifying kidney-yin.

Kidney qi is given birth to by kidney essense, and broad sense kidney qi refers to the functional activity of kidney, includes kidney yin, kidney yang.Narrow sense kidney qi refers in kidney the part playing astringency inducing, the effect of envelope Tibetan, and instability of kidney QI generally, refers to narrow sense kidney qi.Kidney yin is a part for renal function activity, play make moist, Thyme Extract.The implication of usual said kidney yin further comprises kidney essense in fact interior, sometimes specially refers to kidney essense by kidney yin.Therefore the implication of negative and positive is different in different linguistic context.Sometimes represent all functions activity of human body with yang-energy, sometimes singly refer in bodily fuctions's activity and play part that is warm, impetus, therefore will note differentiating.Negative and positive can refer to the gas playing adverse effect in qi of zang-fu viscera, and also can make a comment or criticism gas and pathogen, also can refer to clearing heat in QI system and foul smell.Cloudy gas does not always represent bad, disadvantageous in a word, and yang-energy is always not good yet.Mention cloudy gas and always do not think pathogenic QI in the body, the pathogen of the human body just referred to, it can also refer to a requisite part in human body physiological function activity.In the traditional Chinese medical science, sometimes refer to QI of five ZANG-organs with cloudy gas

Generally, it is aching and limp that insufficiency of kidney-YANG shows as chills and pain of the waist and kness more in symptom, cold extremities with aversion to cold, and especially waist is cool to issue, always wear two pieces clothes than others at ordinary times, nocturia, neurolysis, sexual impotence more, edema, clear urine in large amounts, incontinence or unfavorable, the symptom of the yang deficiency endogenous cold such as pale tongue.It is pointed out that on the one hand, variously to suffer from a deficiency of the kidney all centered by kidney-jing deficiency, so the performance of deficiency of kidney-essence is among various suffering from a deficiency of the kidney; On the other hand, due to by the impact of various factors, specifically everyone performance again with wherein one or more for cardinal symptom." suffering from a deficiency of the kidney " that present society is often said, as seminal emission, sexual impotence, premature ejaculation, hyposexuality, sterile, infertile etc., is actually suffering from a deficiency of the kidney of narrow sense.Sensu lato suffering from a deficiency of the kidney comprises a series of General Symptoms.Chinese traditional treatment is a dialectical process, and a lot of people does not understand oneself to be belong to what symptom, abuse tonic simply, result can only be controlled poorer and poorer.

Fructus Rosae Laevigatae another name sugar jar, Catunaregam spinosa (Thunb.) Tirveng..Belong to rosaceous plant.In China, there is distribution southern each province.Its fruit is sour-sweet edible, and can stir off or make wine.Root, leaf, flower, fruit all hyoscines.Fructus Rosae Laevigatae is the fruit of mountainmahogany plant Fructus Rosae Laevigatae.Sweet in the mouth, micro-acid, puckery, property is put down.Energy controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Containing compositions such as abundant saccharide (fructose, sucrose) and citric acid, malic acid, tannin, vitamin Cs.Oral fruit can promote gastric secretion, helps digest, and has astriction to intestinal mucosa, reduces secretion, prevents diarrhoea.Decoct has inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, dysentery bacterium etc.Laboratory animal serum cholesterol can be reduced, alleviate atherosclerotic degree.

Fructus Rosae Laevigatae root bark obtains through refining tannic extract; Fruit medicine, has diuresis, kidney tonifying functions; Leaf has removing toxic substances and promoting subsidence of swelling effect; Root is medicinal, can promoting blood circulation to remove blood stasis, convergence of drawing out pus by applying a plaster to the affected part, dispel the wind that it is wet to drive.Fruit is containing vitamin C, malic acid, citric acid, tannin, Saponin etc.Not solid for suffering from a deficiency of the kidney, emission and spermatorrhea, the enuresis, frequent micturition, or women's profuse leukorrhea; Insufficiency of the spleen incessant chronic diarrhea, or chronic dysentery large intestine is not solid.In addition, also can be used for the empty vigour of body not solid, proctoptosis, uterine prolapse, metrorrhagia, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, stopping leak dysentery, urine reducing.Fructus Rosae Laevigatae is the famous medicine of the kidney invigorating simply.The traditional Chinese medical science is thought, Fructus Rosae Laevigatae sour in the mouth, and property is put down, and enters kidney, large intestine two warp, has reinforcing the kidney and controlling nocturnal emission, effect of reducing urination and antidiarrheal.Emission and spermatorrhea can be treated, frequent urination and enuresis, leukorrhagia, metrorrhagia, spontaneous perspiration, night sweat, cough due to deficiency of the lung, insufficiency of the spleen dysentery etc.Modern pharmacology research confirms: Fructus Rosae Laevigatae extract can extend the interval between micturition time; Contained tannin has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.

Fructus Rosae Laevigatae fruit unique flavor, there are honey flavour and delicate fragrance, its vegetal pole is enriched, in sugary reducing sugar such as (mainly) fructose, citric acid, malic acid, tannin, vitamin, 20 She's seed amino acids, 18 kinds of mineral elements and the composition such as resin, Saponin, especially with vitamin C and content of reducing sugar higher.According to surveying and determination, the fresh Fructus Rosae Laevigatae sarcocarp of every 100g is containing vitamin C 1009mg, and content is only second to Fructus Rosae Normalis, is 2 times of fresh Fructus Jujubae, 10 times of Fructus actinidiae chinensis, 30 times of mandarin orange.Secondly, Fructus Rosae Laevigatae contains abundant zinc and selenium, and these two kinds of elements are the trace element with specific health care and anti-cancer efficacy of needed by human.

Modern pharmacology proves: Fructus Rosae Laevigatae fruit is oral can promote that gastric secretion helps digest, and intestinal mucosa can be made again to shrink, and secretion reduces and antidiarrheal; Fructus Rosae Laevigatae decocting liquid all has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, dysentery bacterium and influenza virus.1, controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Containing a large amount of acidic materials, soap one-tenth etc. in Fructus Rosae Laevigatae, can pass out semen lingering diarrhea, woman's leukorrhagia of man be prevented too much in controlling nocturnal emission with astringent drugs room, again can astringing intestine to stop diarrhea road, prevent the ineffective caused dysentery of insufficiency of the spleen constraint.2, reducing urination for preventing enuresis.Containing a large amount of acidic materials and Saponin in Fructus Rosae Laevigatae, there is restriction wing and take off sphincter, extend interval between micturition, increase each effect of discharging urine volume, can be used for the disease for the treatment of the enuresis and frequent micturition.3, relieving cough and asthma, spasmolytic.The traditional Chinese medical science is thought, breath with cough and how to be caused by abnormal rising of lung-QI, Fructus Rosae Laevigatae sour-puckery flavor, gas of astringing the lung, can relieving cough and asthma.Modern study finds, the composition containing anti-smooth muscle spasm in Fructus Rosae Laevigatae, can prevent the spasm of gastrointestinal and trachea.4, blood fat reducing.Economize alcohol, hot-tempered matter and soap formula etc. containing fatty acid, Bu Gu in Fructus Rosae Laevigatae, blood fat can be reduced, reduce fat in endovascular deposition, can be used for treating atherosclerosis.5, anti-inflammation.Research finds, Fructus Rosae Laevigatae extracting solution can kill staphylococcus aureus and escherichia coli etc., can be used to treat the disease caused because of S. aureus L-forms or coli-infection.Fructus Rosae Laevigatae is containing citric acid, malic acid, vitamin C, Saponin and abundant saccharide.It is flat that Fructus Rosae Laevigatae nature and flavor are sour and astringent, has effect of reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal.Control spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung are breathed with cough, spontaneous sweating, bleeding not during menses etc., " another name for Sichuan Province book on Chinese herbal medicine " carries " controlling the splenic diarrhea dysentery, only normal urination, arresting seminal emission gas "." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries " controlling with the passing of time dysentery, metrorrhagia leukorrhagia, arresting seminal emission spermatorrhea ".There is excess-fire, pathogenic heat boil diet.

For nocturia, chills and pain of the waist and kness is aching and limp, cold extremities with aversion to cold, and especially waist is cool to issue, and always wears two pieces clothes than others at ordinary times, neurolysis, sexual impotence, edema more, clear urine in large amounts, incontinence or unfavorable, and western medical treatment effect is also not obvious.Chinese medicine also exists dual regulation, when central concentration is too high, may causes certain antagonism, and make drug effect influenced; During low dosage, possible drug level is too low, causes drug effect and does not show.And for the traditional Chinese medical science, no matter be from traditional Chinese medical science mechanism, the dosage form of institute's foundation or the formula components various aspects of medicine all do not have larger breakthrough, take mouthfeel not good, medicine is poor, take very inconvenient, the demand of various patient can not be met, the city life of modern high rhythm can not be met.In the face of more and more ubiquitous insufficiency of kidney-YANG state of urbanite, Chinese Herbs is slow, takes trouble, and the traditional therapy of unsuitable long-term taking does not improve, and effect also not necessarily ideal, can not be accepted extensively by masses.And Chinese medicine health care product just in time whereby opportunity greatly develop, meet people's building body, life happiness hope.Fructus Rosae Laevigatae unique flavor, containing citric acid, malic acid, vitamin C, Saponin and abundant saccharide.The Main way of our exploitation just.

Summary of the invention

Technical problem to be solved by this invention is, for nocturia, chills and pain of the waist and kness is aching and limp, cold extremities with aversion to cold, and especially waist is cool to issue, impotence and premature ejaculation, edema, clear urine in large amounts, incontinence or unfavorable, and western medical treatment effect is also not obvious, thinks thoroughly to cure may not.Chinese medicine also exists dual regulation, when central concentration is too high, may causes certain antagonism, and make drug effect influenced; During low dosage, possible drug level is too low, causes drug effect and does not show.And it is not good to take mouthfeel, medicine is poor, very inconvenient.Chinese medicine also exists dual regulation, when central concentration is too high, may causes certain antagonism, and make drug effect influenced; During low dosage, possible drug level is too low, causes drug effect and does not show.In the face of more and more ubiquitous insufficiency of kidney-YANG state of urbanite, Chinese Herbs is slow, takes trouble, and the traditional therapy of unsuitable long-term taking does not improve, and effect also not necessarily ideal, can not be accepted extensively by masses.

For solving the problems of the technologies described above, the invention provides the Fructus Rosae Laevigatae Chinese medicine health-care oral liquid of a kind of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating, described in it, the parts by weight of Chinese medicine health-care oral liquid crude drug are: Fructus Rosae Laevigatae 10 ~ 50 parts, Rhizoma Cibotii 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Semen Cuscutae 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts.

The Fructus Rosae Laevigatae Chinese medicine health-care oral liquid of described controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating, described in it, the parts by weight of Chinese medicine health-care oral liquid crude drug can be: Fructus Rosae Laevigatae 10 ~ 30 parts, Rhizoma Cibotii 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, Fructus Psoraleae 10 ~ 15 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Semen Cuscutae 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts.

The Fructus Rosae Laevigatae Chinese medicine health-care oral liquid of described controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating, described in it, the parts by weight of Chinese medicine health-care oral liquid crude drug can also be: Fructus Rosae Laevigatae 10 ~ 40 parts, Rhizoma Cibotii 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Semen Cuscutae 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Rhizoma Polygonati 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Paeoniae Rubra 10 ~ 15 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the Fructus Rosae Laevigatae Chinese medicine health-care oral liquid of a kind of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating, and described in it, the preparation process of Chinese medicine health-care oral liquid comprises:

A. the preparation of Fructus Rosae Laevigatae, as component 1;

B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add dextrin after concentrated and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

In described step a, can Maturity be chosen high, without insect pest, without rotting, the Fructus Rosae Laevigatae fruit of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Fructus Fructus Rosae Laevigatae matter is hard, adopts the disintegrating machine of large gap pressure type, is racked and the core of not broken fruit by Fructus Rosae Laevigatae crust, then its pit is steeped 10-15 days in the Chinese liquor of more than 60 degree or edible ethanol.

In described step a, comprise further, can by soaked Fructus Rosae Laevigatae pit heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.

In described step b, the medicine of all the other crude drug can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, becomes component 2.

In described step c, can by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention also provides the Fructus Rosae Laevigatae Chinese medicine health-care oral liquid of a kind of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating, and its preparation process can also be:

A. the preparation of Fructus Rosae Laevigatae, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

C. component 1 and component 2 are mixed, add proper honey after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step b, all the other crude drug can be soaked in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state as component 2.

Fructus Rosae Laevigatae unique flavor, containing citric acid, malic acid, vitamin C, Saponin and abundant saccharide.The present invention is directed to above-mentioned technological deficiency, chosen carefully some reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening Chinese crude drug be prepared into health care oral liquid, the most mouthfeel of these medical materials is light, and drug effect is remarkable, can long-term taking, make people be easy to accept, building body can be reached, enriching yin and nourishing kidney, strengthening bone and muscle, effect of YANG invigorating gas, special in nocturia, chills and pain of the waist and kness is aching and limp, cold extremities with aversion to cold, and especially waist is cool to issue, impotence and premature ejaculation, edema; clear urine in large amounts, incontinence or the vertigo, lethargy, pale complexion or dark; Impotence premature ejaculation, the insufficiency of kidney-YANG symptom effects such as women's infertility are obvious.

Detailed description of the invention

The primary symptom that fear of cold, cold extremities, back feel cold, soreness of waist and knee joint can be used as insufficiency of kidney-YANG, cluster analysis prompting insufficiency of kidney-YANG main symptom, picture of the tongue, pulse condition distribute more regular.Sexual overstrain, overstrain are the Important cause of diseases causing insufficiency of kidney-YANG.Chamber, or claim sexual life, refer to the coitus of men and women.Labor refers to fatigue, and tired finger is tired weary, no matter is physical exertion or mental work, or chamber hyperkinesia all can cause overstrain.Appropriateness is physical, mental and chamber is movable good for health, not restraining or excessive, be then the major incentive that disease occurs.The traditional Chinese medical science is thought, sexual overstrain, overstrain are the two large causes of disease causing suffering from a deficiency of the kidney.Chamber activity can regard shape labor (physical work) and the refreshing labor (ergasia) of specific form as, and too much chamber is movable, except labor shape, a tax on one's mind except, also directly cause the dissipation that kidney essense is too much, of long duration just there will be kidney essense consume.Kidney essense is not only the source that the mankind multiply new life, and is the most important material base of the vital movement day after tomorrow.Deficiency of kidney-essence, will cause then physical weakness, the appearance of even multiple deficient property syndrome and disease.Observe from Point of View of Clinical, the excessive people of chamber usually occurs that waist knee joint is weak, and dizziness and tinnitus is forgetful weak, dim complexion, frequent micturition, man's sun rash, seminal emission, spermatorrhea, woman's menoxenia, the inferior symptom of cold womb band.

Chinese medicine thinks that kidney storing essence is the congenital foundation.The main growth of kidney, growth and reproduction, the raw marrow of main bone lead in brain, brain is the place of marrow and gods high concentration, all thinking activitiess of people are all arranged by brain, the essence of "Nei Jing" is said " the raw then marrow of kidney is discontented with " kidney is the source of people's vital movement, it is the base substance forming human body, essence energy activating QI, gas energy spermatogenesis, kidney spermatogenesis, smart hemopoietic, oligospermia are then sick, and essence is then died to the greatest extent, and the essence gas that declines is then weak, the sufficient gas of essence is then strong, weakness of QI is also then weak, and arrogant blood is then prosperous, qi being the governor of blood, blood being the material foundation of QI, visible essence, gas, blood are mutual dependence for existencies.Cloudy essence is that yang-energy is basic.Yang transforming qi, yin shaping up body, cloudy essence and blood homology, as the shape of depletion of YIN essence, be just not enough to carry yang-energy, so the life of thing, be born in sun; The one-tenth of thing, is formed in the moon, and only have cloudy essence sufficient, yang-energy is vigorous, and the two coordinated balance, human body could be healthy.If congenital defect, lose the day after tomorrow and support, or prolonged illness consumption wound, kidney store essential substances is not enough, and " water loses its source, then the disease of the deficiency of YIN is folded out on the one hand; Fire declines it, then yang deficiency levy storied." can not go up as suffered from a deficiency of the kidney warm in the heart, fill in brain just there will be cardiopalmus, uncomfortable in chest, breathe hard, insomnia and dreamful sleep, dizziness headache, forgetful.The raw obstacle of QI and bloodization just there will be menoxenia, pachylosis.The imbalance of YIN and YANG of kidney just there will be hectic fever, flushed face in the afternoon, sore waist and aching in the waist and the back, sexual hypofunction and climacteric syndrome etc.

Fructus Rosae Laevigatae is the fruit of rosaceous plant Fructus Rosae Laevigatae, also known as Catunaregam spinosa (Thunb.) Tirveng., Fructus Rosae Normalis etc.Fructus Rosae Laevigatae is the famous medicine of the kidney invigorating simply.The traditional Chinese medical science is thought, Fructus Rosae Laevigatae sour in the mouth, and property is put down, and enters kidney, large intestine two warp, has reinforcing the kidney and controlling nocturnal emission, effect of reducing urination and antidiarrheal.Emission and spermatorrhea can be treated, frequent urination and enuresis, leukorrhagia, metrorrhagia, spontaneous perspiration, night sweat, cough due to deficiency of the lung, insufficiency of the spleen dysentery etc.Modern pharmacology research confirms: Fructus Rosae Laevigatae extract can extend the interval between micturition time; Contained tannin has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.

Fructus Rubi temperature; Sweet, sour; Return kidney, urinary bladder channel.For kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Treatment enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." property of medicine opinion ": " main man's kidney-jing deficiency exhausts, woman's food have son.Main impotence." " Japan hanako materia medica ": " settling five organs, beneficial color, supports vital essence, long hair, Qiang Zhi.Treat apoplexy fever of the body and shy." " Kaibao Bencao " carries it: " tonify deficiency is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs, and warming middle-JIAO benefit power, treats strain wind empty, tonifying liver improving eyesight." " Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person, says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, then body is from light, sends out in vain also.Respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have son.Large bright main settling five organs, beneficial color, supports vital essence, long hair, Qiang Zhi.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " explaining abstruseness of the canon of materia medica ": Fructus Rubi, sweetly puts down into kidney, and play a sun and control flaccidity, controlling nocturnal emission with astringent drugs is taken the photograph excessive, kidney tonifying and without scorching partially, controlling nocturnal emission with astringent drugs and evil puckery undoubtedly, the product of gold and jade are also.

Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia." Bencao Jingshu " carries: the main QI invigorating person of Fructus Schisandrae Chinensis, all gas of lung master, and acid can be received, and just entering lung tonifying the lung, therefore QI invigorating also.Its main cough with dyspnea person, the deficiency of vital energy is then above stopped up and is not returned unit, sour flavor having the property of astringing, takes the photograph gas and returns unit, then cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence." not Lu " supports the five internal organs, heat extraction, flesh person in raw the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, tonifying five ZANG-organs of holding concurrently, kidney storing essence, and essence is contained then cloudy strong, and receive and take the photograph, vital qi returns unit, and public region is warmed up, digesting food, steams waste matter and changes precise and tiny, then smart spontaneous, and essence is raw then cloudy long, therefore main as above all diseases also.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.For dysuria, the disease Poria function promoting diuresis to eliminate damp pathogen such as edema, and mild in medicine property and, diuretic and do not hinder healthy energy is promoting diuresis to eliminate damp pathogen key medicine.The disease of all dysuria, retention of water-damp, no matter be partial to cold-damp, or relatively damp and hot, or belong to insufficiency of the spleen wet poly-, all can fit applications.As relatively cold-damp person, can with the compatibility such as Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae; Relatively damp and hot person, can with the compatibility such as Polyporus, Rhizoma Alismatis; The person that belongs to deficiency of spleen-QI, can with the compatibilities such as Herba Taxilli, Radix Astragali, the Rhizoma Atractylodis Macrocephalae; Belong to deficiency and coldness person, also can join Fructus Rubi, the equivalent use of the Rhizoma Atractylodis Macrocephalae.

Semen Cuscutae is listed in top grade in Shennong's Herbal.Its abnormal smells from the patient is pungent, sweet, flat nontoxic.Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, and legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, urine have the diseases such as She's drop, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Generally be listed in top grade can taking for a long time, take improving eyesight for a long time and make light of one's life by commiting suicide and prolong life.But yang deficiency hyperactivity of fire, postcoital protrusion not flaccidity and constipation due to dry stool person prohibit clothes, according to individual physique, if there is sign of getting angry, just cut out.It can cause sexual function hyperfunction.

Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also diseases such as can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.The all cards of the hepatic and renal YIN deficiency, this quality is moistened into kidney, and kind nourishing kidney yin, life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " the true water of large benefit ".Often be equal to use with Rhizoma Dioscoreae, Fructus Corni, the treatment hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst, can invigorating the liver and kidney, beneficial marrow, as LIUWEI DIHUANG WAN.

Fructus Corni, cure mainly pathogen cold and heat under the heart, warming middle-JIAO, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., for China commonly uses rare Chinese medicine, applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " JINGUI SHENQI WAN " with Fructus Corni.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice.

Herba Epimedii is pungent, sweet, warm, returns liver, kidney channel.Energy reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness, is apt to control insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition; Rheumatic arthralgia, atrophic debility of bones paralysis disease." excessive sheep is fiery, and the main impotence of " herbal classic " medicine is hindered absolutely, and " solar corona " also its treatment of first speech man is positive absolutely, and woman is cloudy absolutely, then calling into the gate of vitality, benefit kidney-Yang person is also for " book on Chinese herbal medicine is stated " cloud.The lid gate of vitality be kidney-Yang in kidney, and namely the vigour of the person is also, its so-called exhausted YANG exhaustion the moon, the not vigour of basis, how hiss in both withered.So-called physical strength profiting, Qiang Zhi, and control cold air consumptive disease, muscles and bones contraction is anxious waits card, and all it helps the event of vigour.Old man dusk octogenarian, middle age forgetful, all Yuanyang decay and can not ascensionist also.Must know that this taste is to reduce to liter, its liter is owing to can fall also.

Rhizoma Polygonati: Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, and slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen gas, obtain dizzy, soreness of the waist and knees for deficiency of kidney essence, early whitening of beard and hair and quenching one's thirst.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Rhizoma Cibotii (EastAsianTreeFemRhizome), pharmacognosy is called Rhizoma Cibotii, is the medicine for rheumatism in Chinese medicine.Bitter, sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint.Control back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, lose and drown, frequent micturition, seminal emission, leucorrhea." herbal classic ": main back is strong, machine-operated emergency, general arthralgia cold-damp, gonalgia.Quite sharp old man." not Lu ": treat that losing drowns does not save, man's flaccidity of the lower limbs lumbago, ailment said due to cold or exposure drenches dew, weak breath order Dark, hard ridge, sharp pitching, woman's damaging the spleen and stomach, and joint is heavy." property of medicine opinion ": control man woman poison wind weak foot, pathogen arthralgia chiefly caused by damp pathogen, kidney qi is weak, tonification man, stricture of vagina muscles and bones." detailed outline ": strong Liver and kidney, strong bone, controls wind void.

Fructus Ligustri Lucidi is a kind of conventional Chinese patent medicine, energy nourishing the liver and kidney, strong waist knee joint, for both liver and kidney deficiency, and soreness of the waist and knees, dizzy tinnitus, early whitening of beard and hair, has replenishing kidney-YIN, nourishing the liver to improve visual acuity, except deficiency-heat, the effects such as hearing-improing and eyesight improving.Its property is gentle, nourishing YIN and oiliness stagnant, is suitable for clothes of a specified duration.Fructus Ligustri Lucidi can treat various disease conditions: reason treatment asthenia.Disease sees that body is won thin, soreness of the waist and knees, and one's ears rang and spots danced before one's eyes, early whitening of beard and hair, dry mouth and throat, feverish sensation in the palms and soles, and eyes are dry and astringent dim-sighted, dysphoria and insomnia, and red tongue is tender, thready pulse religion or stringy and thready pulse; Two is treatment of insomnia patients.Disease sees little sleep disturbed by dreams, vexed cardiopalmus, and two dry and astringent, blurred vision, dizzy tinnitus, feverish sensation in the palms and soles, red tongue, thready and rapid pulse, all neurasthenias and the person that has above-mentioned symptom, all can take this side; Three is hair growth diseases.Disease sees that beard and hair is uninteresting not flourish, is easy to come off, or early whitening of beard and hair, dizziness and tinnitus, and order is puckery dim-sighted, and soreness of waist and knee joint is unable, red tongue, thready and weak pulse; Four is treatment seminal emissions.Disease sees soreness of the waist and knees, and cardiopalmus is vexed, and dreaminess is passed out semen, insomnia forgetfulness, the vertigo; Five is treatment hyperlipemias.

Fructus Psoraleae acrid in the mouth; Bitter in the mouth; Warm in naturely return through kidney; Pericardium; Spleen; Stomach; Lung meridian function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence essence; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea." Bencao Jingshu ": Fructus Psoraleae, energy warming the kidney; Raw sun in the moon, the key medicine of excessive fire benefit soil also.Its main five kinds of strain and seven kinds of impairment, the disease of lid edge impairment caused by overstrain, a lot of in asthenia of both the spleen and kidney, with its can warming the kidney, mend fire with the immature soil, then in kidney kidney-Yang be so incensed that mend and rise, then can digesting food, steam waste matter and change precise and tiny.Spleen-QI transporting the essence to the whole body is attributed to lung, supports the five internal organs with honor, therefore the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, and the then air-cooled visitor that takes advantage of a weak point in opponent's defence so that bone marrow wound loses, the cold essence stream of kidney, and kidney governing bones store essential substances, marrow be essence this, the gas of kidney-Yang is solid, and namely, card is shown in, solid itself and yang-energy life, then front card removes in vain.Man is based on essence, and married woman is based on blood, and married woman vim and vigour person, also still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, and the cold essence stream of the kidney with man also

Radix Achyranthis Bidentatae cures mainly soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain." not Lu ": middle weak breath of curing the wound, male kidney yin disappears, and old man loses excessive, and invigorating middle warmer is absolutely continuous, fills out bone marrow, and except pain and pain along the spinal column in brain, married woman's moon water is obstructed, blood agglomeration, and benefit essence, Li Yin gas, only turns white.

Radix Paeoniae Rubra, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Rhizoma Et Radix Notopterygii cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, speckle is bald; Affection of exogenous wind-cold, have a headache lossless, mimeograph cold-damp numbness, edema due to wind pathogen edema, sore swollen toxin.Loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving.

Herba Taxilli is bitter; Sweet; Property is put down.Invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; Muscles and bones flaccidity is weak; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." herbal classic is met former ": She's gas of parasitic Mulberry and give birth to, property is specially dispeled the wind by wet, logical blood circulation regulating, therefore " herbal classic " is got and controlled married woman's lumbago, the diseases such as children's's stiffback, and Xuemaitong is adjusted and skin eyebrow all by its shade, namely must have carbuncle, also must dissipate." book on Chinese herbal medicine is looked for the truth ": Herba Taxilli, number wants agent for kidney tonifying and enriching blood.Edge kidney governing bones, sends out blood main, bitter man's kidney, and it is strong that kidney must mend then muscles and bones, unlikely hemorrhoid repeatly and sensation of aching.Sweetly enrich blood, blood must be mended, send out fill with shady by it and not Fructus Citri tangerinae come off.Therefore all in and lumbago, the sincere disease of muscles and bones, tire are fallen, outer and incised wound, skin rheumatism, what one is not thought whereby and cures mainly.

The specific embodiment of the invention

Specific embodiment 1: it is high that autumn chooses Maturity, without insect pest, without rotting, the Fructus Rosae Laevigatae fruit of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Fructus Fructus Rosae Laevigatae matter is hard, adopts the disintegrating machine of large gap pressure type, is racked and the core of not broken fruit by Fructus Rosae Laevigatae crust, then its pit is steeped 10-15 days in the Chinese liquor of more than 60 degree or edible ethanol.

Then by soaked Fructus Rosae Laevigatae pit heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, and stand for standby use is as component 1.

By Rhizoma Cibotii, Fructus Ligustri Lucidi, Herba Epimedii, Radix Achyranthis Bidentatae, Fructus Psoraleae, Radix Rehmanniae Preparata, Semen Cuscutae, Rhizoma Et Radix Notopterygii, Fructus Corni, Rhizoma Polygonati, Herba Taxilli, Poria, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Fructus Rubi, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 2.

By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 2: it is high that autumn chooses Maturity, without insect pest, without rotting, the Fructus Rosae Laevigatae fruit of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Fructus Fructus Rosae Laevigatae matter is hard, adopts the disintegrating machine of large gap pressure type, is racked and the core of not broken fruit by Fructus Rosae Laevigatae crust, then its pit 5000g is steeped the 10-15 days into more than 60 degree Chinese liquor.Then by soaked Fructus Rosae Laevigatae pit heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, and stand for standby use is as component 1.By Rhizoma Cibotii 1400g, Fructus Ligustri Lucidi 1300g, Herba Epimedii 1400g, Radix Achyranthis Bidentatae 1400g, Fructus Psoraleae 1500g, Radix Rehmanniae Preparata 1400g, Semen Cuscutae 1300g, Rhizoma Et Radix Notopterygii 1300g, Fructus Corni 1400g, Rhizoma Polygonati 1300g, Herba Taxilli 1300g, Poria 1400g, Radix Paeoniae Rubra 1300g, Fructus Schisandrae Chinensis 1300g, Fructus Rubi 1300g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, become component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 3: it is high that autumn chooses Maturity, without insect pest, without rotting, the Fructus Rosae Laevigatae fruit of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Fructus Fructus Rosae Laevigatae matter is hard, adopts the disintegrating machine of large gap pressure type, is racked and the core of not broken fruit by Fructus Rosae Laevigatae crust, then its pit 4000g is steeped the Chinese liquor 10-15 days into more than 60 degree.Then by soaked Fructus Rosae Laevigatae pit heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, and stand for standby use is as component 1.By all the other crude drug Rhizoma Cibotii 1100g, Fructus Ligustri Lucidi 1000g, Herba Epimedii 1000g, Radix Achyranthis Bidentatae 1000g, Fructus Psoraleae 1000g, Radix Rehmanniae Preparata 1100g, Semen Cuscutae 1000g, Rhizoma Et Radix Notopterygii 1100g, Fructus Corni 1000g, Rhizoma Polygonati 1000g, Herba Taxilli 1000g, Poria 1000g, Radix Paeoniae Rubra 1000g, Fructus Schisandrae Chinensis 1000g, Fructus Rubi 1200g to soak in water 12 hours, then extraction pot heated and boiled is put into 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates are combined, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state by component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 4: it is high that autumn chooses Maturity, without insect pest, without rotting, the Fructus Rosae Laevigatae fruit of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Fructus Fructus Rosae Laevigatae matter is hard, adopts the disintegrating machine of large gap pressure type, is racked and the core of not broken fruit by Fructus Rosae Laevigatae crust, then its pit 3900g is steeped 10-15 days in more than 60 degree ethanol.Then by soaked Fructus Rosae Laevigatae pit heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use is as component 1, again by all the other crude drug Rhizoma Cibotii 1000g, Fructus Ligustri Lucidi 1200g, Herba Epimedii 1000g, Radix Achyranthis Bidentatae 1200g, Fructus Psoraleae 1000g, Radix Rehmanniae Preparata 1100g, Semen Cuscutae 1000g, Rhizoma Et Radix Notopterygii 1100g, Fructus Corni 1000g, Rhizoma Polygonati 1000g, Herba Taxilli 1200g, Poria 1000g, Radix Paeoniae Rubra 1000g, Fructus Schisandrae Chinensis 1100g, after described crude drug is put into pulverizer pulverizing by Fructus Rubi 1100g, particulate matter is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, above-mentioned two kinds of extracting solution are merged, as component 2, when to merge component 1 component 2 concentrating under reduced pressure relative density be 70 DEG C 1.38 filtrate, reclaim ethanol, call in dextrin or Mel, bottle after ultraviolet sterilization.

Pharmacological toxicity is tested

One, test material:

(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half; Rats Wistar body weight 130-160g, male and female half and half, the feedstuff of rat, mice is provided by Shandong medical college animal experimental center.

(2) test medicine:

1, medicine of the present invention: the oral liquid that embodiment 2 is made, applies with distilled water diluting during three batch equal amount of mixture experiments.

2, positive control medicine: JINGUI SHENQI WAN, commercially available.

Two, test method and result:

(1) get the healthy mice 80 of body weight 25-28g, female, hero half and half, is divided into four groups respectively by sex and body weight, often organizes 20.1, take medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d, and take positive control drug JINGUI SHENQI WAN for the 4th group, dosage is 6g crude drug/kg/d, is used in conjunction 15 days.

Result of the test: 1,2,3 groups of mices obviously strengthen than 4 groups of mice sexual excitation degree, the number of copulations of 1,2,3 group of mice average every day increases by 3 times than the number of copulations of 4 groups of mices.

Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, thus medicine of the present invention for adjustment human body function equilibrium, QI invigorating, enrich blood, slow down aging strengthens metabolism, neurolysis, sexual hypofunction has treatment foundation.

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the oral liquid that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the oral liquid that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and under She, all death in 12 days is observed in 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, slow down aging strengthens the drug effects such as metabolism, avirulence.

Clinical trial:

Materials and methods

1, material (1) animal: healthy male Wistar rat 40, body weight 180 ± 20g; Adult female rat, 150 ± 20g, 90.There is provided (animal credit number: SCX2008012621) by Shandong Traditional Chinese Medicine University's Experimental Animal Center.Normal diet: produced by Shandong Province's animal science institute, the quality certification number: Shandong animal feed 200802031.(2) main agents estradiol valerate (progynova): French first miraculous cure industry group (Guangzhou) branch company produces, lot number: 03713-2; Gentamycin: Shandong Lu Kangchenxin Pharmaceutical limited company produces, specification: 2ml:8 ten thousand u/ props up " batch number: the accurate font size H37021973 of 01124306 traditional Chinese medicines.Picric acid, heparin, normal saline, platform expect blue solution, TYH culture fluid, the preparation of hospital preparation center, distilled water Deng Dong university of TCM attached middle Shandong.(3) Chinese medicine preparation, JINGUI SHENQI WAN, commercially available, oral.One ball, twice on the one.

Oral liquid of the present invention: Fructus Rosae Laevigatae 30g, Rhizoma Cibotii 11g, Fructus Ligustri Lucidi 12g, Herba Epimedii 11g, Radix Achyranthis Bidentatae 12g, Fructus Psoraleae 11g, Radix Rehmanniae Preparata 12g, Semen Cuscutae 11g, Rhizoma Et Radix Notopterygii 11g, Fructus Corni 12g, Rhizoma Polygonati 12g, Herba Taxilli 13g, Poria 12g, Radix Paeoniae Rubra 12g, Fructus Schisandrae Chinensis 11g, Fructus Rubi 11g.Prepare by embodiment method 2.

(4) instrument: key instrument: microscope: binocular microscope PHSO-16O0x manufacturer: Shanghai Rui Bo educational facilities company limited.General Instrument: syringe, irrigation stomach device, micro sample adding appliance, ice machine, homogenizer, EP pipe, mosquito forceps etc.The court provides.

2. method

(1) rutting period female Mus preparation

All 90 female Mus, every day gavage estradiol valerate suspension 1ml, and confirm with vaginal smear examination keratinocyte " (estradiol valerate suspension compound method: 1mg estradiol valerate is dissolved in 30ml distilled water; make the female two liquor-saturated solution 120ml of valeric acid of 3.3%; every ml contains crude drug 0.033mg, good the day use)

(2) male Mus grouping

Male Mus grouping adopts random digits table, male rat 40 is divided into 4 groups at random: blank group (then be all called for short blank group), overfatigue, sexual overstrain add gentamycin kidney-yang deficiency model group, (then be all called for short model group), JINGUI SHENQI WAN treatment group (then be all called for short golden deficient ball group), treatment group of the present invention (then be all called for short invention group), often organizes 10.

(3) modeling

Each group of experiment carries out 5 weeks, blank group altogether: routine feeding 2 weeks; Every gavage tap water 4ml/d later, maintain 3 weeks, model group: test the 1st week: make every only male Mus and 3 same cages of female Mus in rutting period, and change female Mus in rutting period every day, to induce sexual overstrain (if find pregnant female Mus, the rutting period more renewed immediately female Mus); Test the 2nd week: at depth of water 50cm, water temperature 30 DEG C, in the swimming trunk of volume 0.36ml, force every only male Mus swimming, swim every day 1 time, duration 1 hour, if find, rat is exhausted, after sinking can not on when emerging, picked up rapidly " make it take a momentary rest; then to drop in water again, to induce overstrain; And coordinating every only male Mus lumbar injection gentamycin 150mg/kg every afternoon simultaneously, rear every day, gavage tap water 4ml/d, maintained 3 weeks.Shenqi pill group: modeling method is with above-mentioned model group, and every gavage shenqi pill suspension 4ml/d (containing crude drug 0.55g) after 2 weeks, this method perfusion maintains 3 weeks.Of the present invention group: modeling method is with above-mentioned model group, and every gavage suspension 4ml/d of the present invention (containing crude drug 0.55g) after 2 weeks, this method perfusion maintains 25 days.

(4) ordinary circumstance observation

Whether record body weight, figure, coat gloss, perpendicular hair phenomenon, fear of cold are afraid of cold, whether like crowded together, the whether shrinkage of reaction sensitivity, autonomic activities situation, diet, defecation situation, scrotum, an and record swimming time.

(5) specimen collection

Rats by intraperitoneal injection pentobarbital that (100mg/kg), anaesthetizes, anaesthetizes successfully, cut, take out rapidly two kidney, the emerald green ball of bilateral and attached kingfisher, peeling outer layer tissue and peplos, wash away bloodstain with normal saline, after filter paper blots surface moisture, weigh with analytical balance.

(6) testing process of sperm quality

Sperm count: in sperm suspension instillation cell counting pond, carry out sperm count by automatic counting of red blood.With the sperm count of 5 medium squares in the large lattice of high power lens counting central authorities.

Sperm mobility is analyzed: under 25 DEG C ~ 28 DEG C room temperatures, gets that side is attached starts tail same area, and correct amount 100mg is attached starts tissue, puts into and the vial of 2ml normal saline 37 DEG C of water-bath preheatings is housed, shred into sperm suspension.After leaving standstill 2min in 37 DEG C of water-baths, draw 0.01ml, drip immediately on the blood cell counting plate of 37 DEG C of preheatings, rapid examination under microscope, with reference to motility of sperm grade scale, record the quantity of motile sperm at different levels in about 200 sperms, obtain its percentage rate.

Living spermatozoa percentage is observed: adopt Yihong test, and get sperm suspension and live each 1 mixing of 5% Yihong aqueous solution, high power lens inspection after 305, the sperm of living is not painted, and dead sperm dyes pale red or faint yellow, calculates 200 living spermatozoa percentage.

Sperm Morphologic Study: sperm suspension drawn by suction pipe, filter through 4 layers of lens paper, draw filtrate smear, dry rear methanol and fix smin, 2% eosin stains 1h, uses water fine laundering, dry, under microscope mirror, every animal checks 200-500 complete sperm (every treated animal at least counts 1000 complete sperms), obtains rate of teratosperm.

(7) statistical procedures

Application SPSS13.0 Chinesizing version software carries out date processing, and observe each index and all use t to check, data-x soil-s represents.

(2) result

1. ordinary circumstance

Model group compares with blank group: the obvious weak asthenia of model group animal, lassitude, and it is blunt gradually to react, and autonomic activities also reduces in a large number; Hogback, roll up, visible multiple rat flocks together, and is afraid of cold performance obviously; Hair is comparatively sparse, and coat gloss is poor, often occurs obviously perpendicular hair phenomenon (common after swimming); Feed, amount of drinking water all reduce; Urine amount increases gradually (being judged by the dry wet degree of bedding and padding in cage), has thin during stool; Swimming adheres to that the time progressively shortens, and because fatigue is not propped up, causes " touching the end " also to increase gradually.

Of the present invention group: food-intake comparatively model group, shenqi pill group increases, body weight comparatively model group, shenqi pill group slightly increases, and the pharmaceutical intervention later stage erects hair phenomenon and reduces gradually, partial rat erects hair phenomenon and disappears, fur gloss is better, and autonomic activities is obviously more, and during swimming, anti-fatigue ability is stronger.

The deficient ball group of gold: still compared with normal group is on the low side for food-intake, loses weight, and have perpendicular hair phenomenon, but comparatively model group is improved, the sparse phenomenon of hair is not obvious, and coat gloss comparatively model group makes moderate progress, autonomic activities is general, swimming

Time anti-fatigue ability poor.

2. testis, kidney weight

The comparison of table 1-1 rats with deficiency of kidney-Yang testis, kidney weight (g)

Group	Testicular weight	Kidney weight
			Blank group	3.5144±0.2255*	2.6667±0.2598
Model group	3.25±0.2268	2.9063±0.6304
			The deficient ball group of gold	3.6821±0.2395*	3.112±0.4721
Of the present invention group	3.834±0.3317	3.23±0.5404

Note: testicular weight: compare with model group .P < 0.05

From table 1-1, model group is compared with blank group, testicular weight obviously reduces, there is statistical significance (P < 0.05), gold deficient ball group, of the present invention group compare with model group, testicular weight all obviously increases. all have statistical significance (P < 0.05), but golden deficient ball group compares with of the present invention group, the increase not statistically significant (P > 0.05) of guilt ball weight.Golden deficient ball is described, the present invention all has the effect increasing rats with deficiency of kidney-Yang testicular weight, each group of kidney weight compares, equal not statistically significant (P > 0.05).Therefore, illustrate that this experimental model and pharmaceutical intervention group have no significant effect rat kidney total amount.

3, sperm quantity, sperm motility.

Table 1-2 rats with deficiency of kidney-Yang sperm quantity (10 ⁵), the comparison of sperm motility

Note: sperm quantity: compare with model group, * P < 0.05; Sperm motility: compare with model group, #P < 0.01, compares with shenqi pill group, ##P < 0.05

From table 11, model group rats sperm quantity, sperm motility is starkly lower than blank group and (is respectively P < 0.05, P < 0.01), of the present invention group of sperm quantity and activity ratio all (are respectively P < 0.05 higher than model group, P < 0.01), the deficient ball group activity ratio of gold is significantly higher than model group (P < 0.01), sperm quantity is improved trend compared with model group, but not statistically significant (P > 0.05), and of the present invention group of sperm motility is higher than the deficient ball group of gold (P < 0.05).

Golden deficient ball is described, the present invention all can improve rat spermatozoa quantity and activity ratio, and effect of the present invention is better than shenqi pill.

4. living spermatozoa percentage, abnormal rate

The comparison of table 1-3 rats with deficiency of kidney-Yang living spermatozoa percentage, rate of teratosperm

Group	Living spermatozoa percentage	Rate of teratosperm
			Blank group	79.2222±4.3237#	2.11±1.25##
Model group	65.875±3.9074	3.25±0.5244
			Shenqi pill group	72.63±5.5946*	2.24±1.5572

Of the present invention group

78.23±5.3184#

2.33±1.0000&

Note: living spermatozoa percentage: compare with model group, #P < 0.01, * P < 0.05, rate of teratosperm: compare with model group, ##P < 0.05, & P < 0.02 is from table 1-3, model group rats living spermatozoa percentage is significantly lower than blank group (P < 0.01), rate of teratosperm is then higher than blank group (P < 0.05), the deficient ball group of gold, of the present invention group is compared with model group, living spermatozoa percentage (is respectively P < 0.05 higher than model group, P < 0.01), of the present invention group is compared with the deficient ball group of gold the trend being improved living spermatozoa percentage, but not statistically significant (P > 0.05).Of the present invention group of rate of teratosperm is starkly lower than model group (P < 0.01), and golden deficient ball group then improves not obvious (P > 0.05) to rate of teratosperm.Visible, golden deficient ball, of the present invention group all can improve living spermatozoa percentage, reduce abnormal rate, but effect of the present invention is slightly better than golden deficient ball.

Three, rats with deficiency of kidney-Yang effect of Sex Gland Hormone assay

Gonad axis associated hormone has very important effect in the emerald green ball sexual cell growth and development process of promotion, maintains the stable of emerald green ball During spermatogenesis simultaneously.Therefore, further investigate the mensuration of different the kidney invigorating method to rats with deficiency of kidney-Yang gonad axis associated hormone content, on the impact of the different the kidney invigorating method of announcement on sexual cell and During spermatogenesis, there is most important theories and clinical value.

(1) materials and methods

1. material

(1) animal is with experiment one

(2) reagent: rat starts ketone (T), rat follotropin (FSH), rat corpora lutea generation element (LH),

EUSA detection kit: ADL Products.

(3) key instrument is with experiment two

2. method

(1) animal grouping, model copy, administration etc. are all with experiment one.

(2) test after modeling, medication terminates to get blood respectively afterwards, and measure T, FSH, LH, experimental procedure is substantially with experiment two

(3) statistical procedures

Adopt SPSS13.0 software to process, two groups of t inspections of comparing, data-x soil-s represents

(2) result

1. the change of testosterone (T)

Table 3-1 respectively organizes the comparison of testosterone (ng/mI) level

Group	After modeling	After medication
			Blank group	8.5884±1.7983	9.8363±1.0709
Model group	6.6727±0,985*	6.8565±1.3841
			The deficient ball group of gold	6.6021±0.7815*	7.2322±1.1524
Of the present invention group	6.7023±1.1717*	8.1321±1.3823#

Note: after modeling, compares with blank group, * P < 0.05; Of the present invention group, compare before and after medication, #P < 0.05.From table 3-1, modeling three groups, testosterone levels all declines (P < 0.05), after medication, gold deficient ball group highland ketone level has rise trend, but not statistically significant (P > 0.05), and of the present invention group of testosterone levels comparatively recovers obviously (P < 0.05) after modeling, illustrate that the present invention has restitution to rats with deficiency of kidney-Yang highland ketone level, and effect is better than shenqi pill.

2. the change of Folliculogenesis element (FSH)

Table 3-2 respectively organizes the comparison of Folliculogenesis element (Iu/L) level

Group	After modeling	After medication
			Blank group	5.2334±1.9621	5.3687±1.705
Model group	3.1773±0.988*	3.1859±1.1164
			The deficient ball group of gold	2.745±1.5432*	4.9532±1.8632
Of the present invention group	3.1645±1.3472	5.1421±1.1872#

Note: after modeling, compares with blank group, * P < 0.05, compare before and after the medication of Yougui Wan, the kidney-Yang-Reinforcing Bolus group, #P < 0.05 is from table 3-2, rat Folliculogenesis element level can be caused after modeling be starkly lower than blank group (P < 0.05), after medication, after shenqi pill group and modeling of the present invention, trend rats with deficiency of kidney-Yang FSH being had to recovery is compared with model group, but not statistically significant (P > 0.05), comparing FSH level before and after of the present invention group of medication recovers obviously (P < 0.05), rise is compared more obvious with after the medication of shenqi pill group, but not statistically significant (P > 0.05).Illustrate that modeling process can make rat FSH level decline, the present invention has restitution to rat FSH level, and effect is better than shenqi pill.

3. the change of lutropin (LH)

The comparison of table 3-3 lutropin (mIu/ml) level

Group	After modeling	After medication
			Blank group	3.9215±0.7149	4.1127±0.9956
Model group	3.1496±0.521*	2.8463±1.84
			The deficient ball group of gold	3.1525±0.5289*	3.4198±0.9299
Of the present invention group	3.0273±0.8903*	3.6354±0.5635

Note: after modeling, compares with blank group, and * P < 0.05 is from table 3-3, and after modeling, each group rat LH level is lower than blank group (P < 0,05), has statistical significance.After medication, golden deficient ball group, of the present invention group of LH level all have rise trend, but respectively with compare not statistically significant (P > 0.05) before medication.Illustrate that modeling process can cause rat LH level to decline, golden deficient ball, of the present invention group may there is the effect recovering LH level, but medication the latter two compare no significant difference (P > 0.05).

Discuss

By modeling, model group animal occurs that the yang deficiency such as obvious weak asthenia, active movement minimizing promote unable caused performance; , also occurred due to kidney yang deficiency, unable the rousing oneself of the mind and occur that lethargy is depressed, the performances such as bradykinesia meanwhile, hogback, to have rolled up, the performances of being afraid of cold such as gathering belong to yang deficiency can not warm not as good as caused by; Hair is sparse, and fur owes gloss etc. for suffer from a deficiency of the kidney for a long time, fur lose in moisten foster caused by; Feed, amount of drinking water all reduce, just the pool may because insufficiency of kidney-YANG, and YANG failing to warm spleen-YANG, caused by dysfunction of the spleen in transportation; Urine many genus insufficiency of kidney-YANG, can not caused by promote the circulation of qi and water.Pharmaceutical intervention group, experimental rat Kidney-Yang Deficiency Syndrome is all improved in varying degrees, and is now compared as follows: treated animal autonomic activities of the present invention, fur gloss intensity, and especially food-intake improvement is better than shenqi pill group.Shenqi pill treated animal food-intake is even not as good as model group animal, and no significant difference is improved in other aspects.Illustrate that shenqi pill, the present invention all can improve the symptom of the insufficiency of kidney-YANG of experimental rat in various degree, and effect of the present invention is slightly better than golden deficient ball group.

From shenqi pill and prescription angle of the present invention, invigorating middle warmer of the present invention has rushes down, and residence rushes down in benefit, and Poria can play function of invigorating spleen.The spleen being the foundation of acquired constitution, source of generating QI and blood, if the strong fortune of spleen and stomach function, then QI and blood not only can be made sufficient, and also can supplement nutrition the day after tomorrow, and play the effect of indirect the kidney invigorating, from this angle, the present invention has effect of spleen reinforcing concurrently.

Semen quality is one of important indicator of male reproductive function.Its detection mainly comprises sperm quantity, activity ratio rate of teratosperm etc.From the experimental results, golden deficient ball, the present invention all comparatively significantly can increase the emerald green ball weight of rat, have no significant effect kidney weight.The two compares no significant difference (P > 0.05) to the increase of testicular weight.Gold deficient ball, the present invention all can improve rat spermatozoa quantity, survival rate, enhancing sperm motility, and as can be seen here, shenqi pill, ball of the present invention all can improve rat spermatogenesis ability, and effect of the present invention comparatively shenqi pill is more obvious.

Specific embodiment: Lee, man, 36 years old, readme white collar, operating pressure is large, at ordinary times towards nine evenings five, overtime work of often staying up late, often feel nocturia recently, chills and pain of the waist and kness is aching and limp, cold extremities with aversion to cold, especially waist is cool to issue, and always wear two pieces clothes than others at ordinary times, neurolysis, sexual life has some setbacks more, spontaneous perspiration.Palpitation and insomnia is forgetful, sallow weak, removes examination in hospital, does not have organic disease.Just subhealth state.Be unwilling to take Chinese medicine, dislike its abnormal smells from the patient poor, use oral liquid of the present invention, Fang Yong: Fructus Rosae Laevigatae 30g, Rhizoma Cibotii 12g, Fructus Ligustri Lucidi 12g, Herba Epimedii 11g, Radix Achyranthis Bidentatae 12g, Fructus Psoraleae 11g, Radix Rehmanniae Preparata 12g, Semen Cuscutae 14g, Rhizoma Et Radix Notopterygii 11g, Fructus Corni 12g, Rhizoma Polygonati 12g, Herba Taxilli 13g, Poria 12g, Radix Paeoniae Rubra 12g, Fructus Schisandrae Chinensis 12g, Fructus Rubi 11g.After using a week, nocturia phenomenon is obviously improved.Almost no longer get up in the night to urinate in the evening.The mental status takes a turn for the better, and palpitation and insomnia is forgetful, and sallow weak phenomenon is improved, but sexual life people is as one wishes not to the utmost.After continuing 2 weeks of use, no longer fear cold fearness and tremble with fear, sexual life is smooth, conjugal harmony.Chills and pain of the waist and kness is aching and limp no longer to be occurred.Start on the one hand to take exercise, be careful in one's diet, continue on the one hand to use the present invention as daily tonification.

Claims

1. the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating, it is characterized in that, the parts by weight of described health care oral liquid crude drug comprise: Fructus Rosae Laevigatae 10 ~ 50 parts, Rhizoma Cibotii 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Semen Cuscutae 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts.

2. the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 1, it is characterized in that, the parts by weight of described health care oral liquid crude drug comprise: Fructus Rosae Laevigatae 10 ~ 30 parts, Rhizoma Cibotii 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, Fructus Psoraleae 10 ~ 15 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Semen Cuscutae 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts.

3. the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 1, it is characterized in that, the parts by weight of described health care oral liquid crude drug comprise: Fructus Rosae Laevigatae 10 ~ 40 parts, Rhizoma Cibotii 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Semen Cuscutae 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Rhizoma Polygonati 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Paeoniae Rubra 10 ~ 15 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts.

4. a Fructus Rosae Laevigatae health care oral liquid for controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to any one of claims 1 to 3, is characterized in that, the preparation process of described Chinese medicine health-care oral liquid comprises:

A. the preparation of Fructus Rosae Laevigatae, as component 1;

5. the preparation method of the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 4, is characterized in that, in described step a, chooses Maturity high, without insect pest, without rotting, and the Fructus Rosae Laevigatae fruit of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Fructus Fructus Rosae Laevigatae matter is hard, adopts the disintegrating machine of large gap pressure type, is racked and the core of not broken fruit by Fructus Rosae Laevigatae crust, then its pit is steeped 10-15 days in the Chinese liquor of more than 60 degree or edible ethanol.

6. the preparation method of the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 4, is characterized in that, in described step a, comprise further, by soaked Fructus Rosae Laevigatae pit heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.

7. the preparation method of the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 4, it is characterized in that, in described step b, the medicine of all the other crude drug is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, becomes component 2.

8. the preparation method of the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 4, it is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

9. controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to any one of claims 1 to 3 Fructus Rosae Laevigatae health care oral liquid a preparation method, it is characterized in that, its preparation process can also be:

A. the preparation of Fructus Rosae Laevigatae, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

10. the preparation method of the Fructus Rosae Laevigatae health care oral liquid of controlling nocturnal emission with astringent drugs reducing urination the kidney invigorating according to claim 9, is characterized in that, in described step b, to be soaked by all the other crude drug in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state as component 2.