CN104435169A - Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of traditional Chinese medicine combination - Google Patents

Abstract

The invention provides a traditional Chinese medicine combination for treating bone injury and fracture. The traditional Chinese medicine combination for oral administration comprises the following crude drugs: Indian bread, red sage root, cornus officinalis, acanthopanax bark, rhizome of Sichuan lovage, large leaf gentian root, loranthus muberry mistletoe, achyranthes root, safflower, ground beetle, caulis spatholobi, rhizome of drynaria, giant knotweed, psoralea fruit, elderberry, buck grass, cassia twig, earthworm, red peony root, heroubill geranium, ledebouriella root and epimedium; the traditional Chinese medicine combination for external use comprises the following raw materials: anisetree bark, myrrh, frankincense, dipsacus root, notoginseng, safflower, dragon's blood, nux vomica, black catechu, radix aconiti preparata, cassia, caulis impatientis, dahurian angelica root, triperygium wilfordii, Chinese clematis, notopterygium root, earthworm and dried body of scorpion. The traditional Chinese medicine combination has the efficacies of promoting blood circulation to remove blood stasis, promoting reunion of fractured bones, removing stasis to relieve pain and promoting focus repair, and is applicable to the treatment of various types of bone injury and fracture, and is high in cure rate. The traditional Chinese medicine combination ensures that patients are free from the pain of bone fracture and are not required to take strong paregoric. The traditional Chinese medicine combination ensures that callus is rapidly formed and the physiological healing stage is obviously advanced, thereby achieving the purpose of treating bone injury and fracture. The traditional Chinese medicine combination for oral administration has the effects of relieving distension, relieving pain, eliminating stasis, engendering the new and promoting the callus growth, and the traditional Chinese medicine combination for external use can ensure that the callus is rapidly formed and the physiological healing stage is obviously advanced.

Description

Chinese medicine composition of a kind of set a broken bone fracture and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly one the Chinese medicine composition of set a broken bone fractureand preparation method thereof.

Background technology

Fracture is clinical common multiple disease, and orthopedics and traumatology of Chinese medicine has the history of several thousand in China, in fractures, have accumulated rich experience."Nei Jing" is said: " impairment of QI resulting in pain, injury of configuration resulting in swelling ".Wang Bing note: " gas is invisible therefore grieved, and the tangible then wound of blood is swollen ".Fracture and injury QI and blood, hyperamization arteries and veins is from through absurd row, and stagnant blood is detained, and form blood stasis, so that QI-blood circulation is not normal, and the stasis of blood is long-pending does not fall apart, for swelling as pain." blood not reviver's stasis of blood does not go, and the stasis of blood does not go then can not connect " therefore control and work as blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone Orthopedics of Chinese Medicine is a control osteoarthrosis and muscles damage around thereof and the subject of disease.Ancient genus " surgeon " category, also known as; Synthetism; Bonesetting; Traumatology; Deng.Orthopedics and traumatology of Chinese medicine is with a long history, of long standing and well established, the long-term summaries of experience of struggling with damage muscles and bones illness of Chinese people of all nationalities, there is abundant academic content and distinguished medical treatment achievement, the important ingredient of Chinese medicine, to the Chinese nation multiply and be prosperous and the development of world medicine creates far-reaching influence.

Fracture is that the structural continuity in epiphyseal plate or joint is separated or interrupts.That fractures is categorized as closure and opening, imperfection and completeness is divided into by the breaking degree of fracture, stability and unstability can be divided into again by manual reduction, be divided into fissure fracture, subperiosteal fracture, cortical bone or periosteum portion fractures to fracture, tear fracture, transverse fracture, oblique fracture, spiral fracture, comminuted fracture, epiphysiolysis, compression fracture, depressed fracture etc. by the form of fracture line.At present, large hospital is all generally first by after fracture site normotopia with artificial to the treatment of fracture patient, with steel wire or with steel plate, Boards wall, and then at affected part outside plaster fixing, bed is rested, and this method relies on the spontaneous recovery regeneration capacity of the human body of patient own to engage fracture site; Or taking the blood circulation promoting medicines such as some similar YUNNAN BAIYAO again, object promotes that fracture heals or stop-pass antiinflammatory early; So-called " 100 days injured in the sinews or bones " need three months after fractures or the recovery of longer time in other words, namely dally over one's work, bring misery again to patient.

In the repair process of fracture, periosteum and perimyelis play a major role.Union of fracture can complete i.e. organization of hematoma phase, primary callus phase and callus by the phase of three evolution gradually and transform the phase.The organization of hematoma phase: after fracture, the angiorrhexis of bone stump and surrounding soft tissue thereof is hemorrhage, formation hematoma, a small amount of cortical bone of bone stump is downright bad because of ischemia, hematoma condenses into the blood clot containing reticular fiber for 6 ~ 8 hours after wound, then blood capillary proliferation fibroblast, phagocyte invades from all quarter, make hematoma machineization formation fibrous connective tissue gradually, the osteoblast proliferation of inside and outside film, to forming the osteoid tissue with key longitudinal axis when 3 weeks, fracture site is tentatively connected, is called fibrous callus.The primary callus phase: in bone, the osteoblast of adventitia inside and outside the broken ends of fractured bone, form osteoid tissue and calcification forms area of new bone gradually, claim intramembranous ossification, both are close to interior (internal callus) of cortical bone, (external callus) two sides outward, the fibrous connective tissue formed by organization of hematoma between the broken ends of fractured bone, cartilage is changed in large portion into, chondrocyte is through hyper-proliferative, degeneration, calcification and ossify as bone internalization bone, form the callus comprised in pulp cavity and the ring-type callus being sandwiched in interior external callus respectively, external callus, internal callus, ring-type callus, intracavity callus " joins forces " fusion, and it is completely ossified, complete the primary callus phase, that is the clinical healing phase.The callus transformation phase: be made up of the little fine strain of millet of the bone of irregular arrangement, owe firmly primary callus, along with the heavy burden of limbs, bone trabecula grows along stress axis, and queueing discipline and densification, this process is removed and osteoblast evolution by engulfing of osteoclast, forms permanent bone and connect.The treatment of fracture should play a role mainly for above-mentioned different pathologic stage.

At present, the method for the treatment of fracture mainly comprises Chinese traditional treatment and western medical treatment.Western medical treatment fracture mainly contains manual reduction and extenal fixation such as plintlet binder is fixed and continuous traction etc., open reduction internal fixtion etc. is generally taked to critically ill patient, painful large because performing the operation, costly, postoperatively may leave over sequela, and make majority be reluctant to accept.Traditional Chinese medical science traditional therapy is pain relieving by force often, symptomatic treatment in acute condition, the rules such as relieving the primary symptom in a chronic case, and that tests is clinical, though there is certain curative effect, control symptom and produce effects slowly, healing only has the wait physiology normal healing phase, is about 7 ~ 10 weeks, and patient's course of disease and painful phase extend.For such situation, clinically can effectively alleviate sufferer misery in the urgent need to one, also can the medicine of accelerating union of bone fracture.

But, usually emphasize that entirety treats, motherland's medical science for the treatment of must aim at the pathogenesis of disease early have research to this disease, and be longer than blood circulation promoting and blood stasis dispelling, Anshen Bunao, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening traditional black plaster very good clinical therapeutic efficacy is achieved to it.

Plaster external application is excited nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in bone, makes it to return produce and absorb dynamic equilibrium, reaches and eliminates osteodynia inflammation and the object of fully recovering." Chu is sick in interior, must shape in outer ".When symptom appears in certain position of human body, according to the trend of meridians, to launch at bone injury position and corresponding acupuncture point thereof during treatment simultaneously, and carry out cream cave combined treatment the corresponding course for the treatment of in accordance with this disease, to reach treating both the principal and secondary aspects of a disease, thoroughly cut off the object of recurrence root, external application stimulating acupoint, dredging microcirculation, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel bone Liquid Absorption, make it to return and produce and absorb dynamic equilibrium, reach and eliminate osteodynia inflammation and the object of fully recovering.Internal and external medicine can also alleviate the side reaction that Western medicine brings, thus demonstrates its advantage place.

Summary of the invention

At present, the majority for the treatment of fractures and bone injuries adopts patient beats the methods such as clamping plate, plaster fixing, operation traction, and the course for the treatment of is long, and cure slow, patient pain unbearably, so far, does not also have one to alleviate patient suffering, cures the preparation of the pure internal and external medicine of fast ideal.In order to overcome above-mentioned deficiency, play clamping plate during reduction of patient fracture, pain that plaster fixing, operation cause, select invigorate blood circulation, blood stasis dispelling, pain relieving Chinese crude drug, for fracture site activate perimyelis, periosteum the rapid calcification of osteoblast, and then promote New born formation have special efficacy.The present invention has blood circulation and removing stasis, reunion of fractured tendons and bones, eliminating stagnation analgesic therapy, promotes focus reparation, is applicable to the treatment of various bone fracture, and the Chinese medicine composition that cure rate is high.Patient is made to remove the hardship of the hurt like hell of fracture, without the need to using strong analgesic again.Callus formation is rapid, and the physiological healing phase obviously shifts to an earlier date, thus reaches the object of set a broken bone fracture.

For solving the problems of the technologies described above, provide one the Chinese medicine composition of set a broken bone fracture, be made up of endo-medicine and external used medicine, described endo-medicine comprises the crude drug of following weight portion: 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Cortex Acanthopancis 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, Ramulus Sambuci Williamsii 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Erodii 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts,

External used medicine comprises the crude drug of following weight portion: Cortex Illicii 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Sanguis Draxonis 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, 10 ~ 20 parts, catechu, Radix Aconiti Preparata 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Scorpio 10 ~ 20 parts.

Described the Chinese medicine composition of set a broken bone fracture, the crude drug of following weight portion can be comprised: 10 ~ 15 parts, Poria in endo-medicine described in it, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Cortex Acanthopancis 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Radix Gentianae Macrophyllae 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Rhizoma Drynariae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, Ramulus Sambuci Williamsii 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Erodii 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts,

The crude drug of following weight portion can be comprised: Cortex Illicii 10 ~ 15 parts, Myrrha 10 ~ 15 parts, Olibanum 10 ~ 15 parts in external used medicine, Radix Dipsaci 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Sanguis Draxonis 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, 10 ~ 15 parts, catechu, Radix Aconiti Preparata 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Scorpio 10 ~ 20 parts.

Described the Chinese medicine composition of set a broken bone fracture, the crude drug of following weight portion can also be comprised: 10 ~ 20 parts, Poria in endo-medicine described in it, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Cortex Acanthopancis 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Fructus Psoraleae 10 ~ 15 parts, Ramulus Sambuci Williamsii 10 ~ 15 parts, Herba Lycopodii 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Herba Erodii 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts,

The crude drug of following weight portion can also be comprised: Cortex Illicii 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Olibanum 10 ~ 20 parts in external used medicine, Radix Dipsaci 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Sanguis Draxonis 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, 10 ~ 20 parts, catechu, Radix Aconiti Preparata 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Tripterygii Wilfordii 10 ~ 15 parts, Radix Clematidis 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Scorpio 10 ~ 15 parts.

Described the Chinese medicine composition of set a broken bone fracturemedicine, described endo-medicine dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, plaster, cream and drop; Described external drug dosage forms can be: unguentum, spray, liniment, ointment and emplastrum.

For solving the problems of the technologies described above, the present invention also provides a kind of the Chinese medicine composition of set a broken bone fracturepreparation method, the dosage form of described endo-medicine is tablet, and its preparation method comprises:

A. all crude drug are put into ethanol heating and refluxing extraction 2 times, as component 1;

B. get the medicinal residues after above-mentioned ethanol extraction again, the heating and refluxing extraction that adds water 2 times, as component 2;

C. said components merged, spraying dry after decompression recycling ethanol, obtains medicated powder; Tablet made by mixing starch tabletting.

In described step a, first all crude drug can be cut into coarse granule, then put into ethanol, soak more than 2-5 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, concentrated 30 minutes ~ 45 minutes of heating, is concentrated into extractum shape, stand for standby use, becomes component 1.

In described step b, the medicinal residues that above-mentioned ethanol extraction is crossed can be added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.

In described step c, above-mentioned two kinds of component extractum can be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.1g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 80 DEG C 1.38; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain crude drug medicated powder dress, tablet made by mixing starch tabletting.

For solving the problems of the technologies described above, the present invention also provides a kind of the Chinese medicine composition of set a broken bone fracturepreparation method, the dosage form of described external used medicine is plaster, and its preparation method comprises:

First Radix Notoginseng, Sanguis Draxonis, Olibanum, Myrrha, Cortex Cinnamomi and the Rhizoma Et Radix Notopterygii way of distillation are vaporized into crystallization, pulverize for subsequent use; Added by other crude drug in the Oleum Sesami accounting for its 5-10 times weight portion and soak 3-5 days, heating extraction, first big fire is boiled, and after Oleum Sesami boiling, firepower reduces, enduring to pharmaceutical presentations is dark brown, and inner coke yellow, pulls medicinal residues out, continued to temper by medicine oil, and constantly stir, refining is to the beading that drips; Again Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity; Slowly added by Plumbum preparatium in the medicine oil refined, constantly stir, become the thick paste of black, in the slightly cold rear impouring cold water of the plaster refined, soak 5-10 days, change water every day once, releasing fire-toxin, the crystalline powder then mixing vaporization stirs.

For solving the problems of the technologies described above, the present invention reoffers one the Chinese medicine composition of set a broken bone fracturepreparation method, the dosage form of described external used medicine is ointment, and its preparation method comprises, and first Radix Notoginseng, Sanguis Draxonis, Olibanum, Myrrha, Cortex Cinnamomi and the Rhizoma Et Radix Notopterygii way of distillation is vaporized into crystallization, pulverizes for subsequent use; Again all the other crude drug are added and account for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; Then the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use; Finally above-mentioned 2 kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, adds the crystalline powder prepared, and the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste shape.

The using method of unguentum of the present invention: fracture Chinese medicinal plaster is attached on broken ends of fractured bone corresponding site epidermis, then the mulching of external suitable size red cloth seals, fracture as there being 2-3 place simultaneously and namely paste with 2-3,4 ~ 5 days time was changed once, fixed after the broken ends of fractured bone drug of topical application with plintlet; Or externally used paste heating of the present invention is concentrated into pasty state, and be in harmonious proportion spread on bone fracture sore spot with wine, vinegar, Mel, pasting medicine part need clean, and fixes with preservative film, medical adhesive tape.

During the drug of topical application, arbitrarily not mobile, in order to promote the calcification of broken ends of fractured bone area of new bone, callus transformation is fast, and bone trabecula generates fine and close, the food that edible calcic is high and take some calcareous medicine.To some special fractures as Intertrochanter fracture of femur etc., so long as not obvious dislocation, also within latter 7 days, use we again without the need to open wound being carried out conventional treatment stitching with incision draw point fixing interior reset (comprising comminuted fracture) for open fracture.

Chinese medicine composition of the present invention activates the rapid calcification of osteoblast of perimyelis, periosteum for fracture site, and then promotes that New born formation has special efficacy.There is blood circulation and removing stasis, reunion of fractured tendons and bones, eliminating stagnation analgesic therapy, promote focus reparation, be applicable to the treatment of various fractures and bone injuries, and the Chinese medicine composition that cure rate is high.Patient is made to remove the hardship of the hurt like hell of fracture, without the need to using strong analgesic again.Callus formation of the present invention is rapid, and the physiological healing phase obviously shifts to an earlier date, thus reaches the object of set a broken bone fracture.

Detailed description of the invention

Fracture is in daily life, sports, and in work safety accident, especially in traffic accidents, along with vehicle increases gradually, fracture in direct ratio increasing; Apply routine operation treatment fracture clinically, normal to cut (closed fracture) reconstructive therapy, because of cleavage fracture surrounding soft tissue, have also at fracture upper steel plate and draw point, in human body, insert foreign body, bring new plane wound, be unfavorable for the blood fortune supply of fracture repair, delayed union or disunion, the even bone necrosis of fracture can be caused, last amputation, causes patient lifelong maimed.

Union of fracture (fracture healing) is a complicated pathological processes, in periosteum, osteoblastic regeneration is the basis of union of fracture, its agglutination can be divided into hematoma to be formed, fibrous callus is formed, the process of the several alternately evolution successively of reconstruction of osseous callus formation and callus, union of fracture is divided into intermembranous ossification and endochondral ossification, fracture in latter 24 hours, the periosteum at fracture end place starts hypertrophy plumpness, the internal layer hyperplasia of periosteum, produce osteoid tissue, form area of new bone, i.e. intermembranous ossification, its process is rapid, and be connected firmly.When os endochondrale is fracture, periosteum bone cortex and contiguous soft tissue are damaged, angiorrhexis is hemorrhage, hematoma is formed at fractures, because blood cell destroys, Fibrin exudation, granulation tissue is formed, hematoma starts machine, hematoma is surrounded by the proliferation of fibrous tissue being positioned at perihematoma, and stretches into wherein, is replaced by absorption by the effect of phagocyte and foreign-body giant cell.

Chinese herbal medicine, its property of medicine is under the assosting effect of wine, and penetration is strong, directly penetrates into periosteum, bone marrow and blood vessel and nerve, repairing under the neural effect of memory, recovering hemopoietic function of bone marrow, freeing circulation of the blood, and bone mass cells division forms new bone.At the bones and muscles injury initial stage, hemorrhage, forms hematoma, blocks passages through which vital energy circulates, coagulation of QI-blood." the large opinion of Plain Questions YIN YANG classification of natural phenomena " proposes " impairment of QI resulting in pain, injury of configuration resulting in swelling ", i.e. early injury, must have the clinical manifestation of swelling and ache.The present invention activates various skeletal growth factor by effective Chinese medicine, the activity of stimulating osteoblast, is following under the effect of medicine, and the efficacy of a drug is gone directly bone injury place, accelerating union of bone fracture; Because trauma fracture must cause meridians in body, QI and blood and function disorderly, cause QI and blood to fear wound, disharmony of nutrient QI with defensive QI, internal organs are got along well, and meridians check, and bone marrow, periosteum and surrounding tissue and blood fortune are destroyed; The present invention emphasizes treatment by oral administration of medicines, while blood circulation promoting and blood stasis dispelling, dual-purpose tonifying QI to promote blood circulation, hemopoietic, nourish blood, the agent of the liver and the kidney tonifying, execute it by following through, the efficacy of a drug is concentrated, to follow through medicine as guide is gone directly bone injury place, all medicines share, and reach the object of blood circulation promoting and blood stasis dispelling, fast reunion of fractured tendons and bones.Priming of the present invention return through, at blood circulation promoting and blood stasis dispelling simultaneously, dual-purpose tonifying QI to promote blood circulation, hemopoietic, nourish blood, tonifying liver QI invigorating, and can effectively pain relieving, execute it by following through, the efficacy of a drug concentrated, the Chinese medicine preparation of a kind of fast fracture-setting at the bone injury place that goes directly.

Side is with Radix Angelicae Sinensis, blood circulation promoting and blood stasis dispelling; Radix Notoginseng, Flos Carthami blood circulation promoting and blood stasis dispelling, muscles and tendons relaxing to alleviate pain; Dredging the meridian; With Radix Angelicae Sinensis, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, eliminate the stasis of blood stagnant, dredging the meridian; With Radix Angelicae Sinensis, Radix Achyranthis Bidentatae righting benefiting QI and nourishing blood, make healthy energy internal memory, pathogenic factor gradually moves back; From modern medicine angle, we have the function of antiinflammatory, analgesia, immunity moderation.Wherein Radix Angelicae Sinensis, Rhizoma Chuanxiong, have and improve local microcirculation, suppress humoral immunization, eliminate local inflammation; And Radix Angelicae Sinensis, etc. can regulate cellular immune function.All medicines share, treating both the principal and secondary aspects of a disease, both more holistic macro readjustment of direction, pay attention to again localized micro treatment, have dialectical and differential diagnosis of diseases, the feature that local and global deformation combines, therefore can obtain good clinical efficacy.In side, Caulis Spatholobi, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Olibanum, Myrrha, Fructus Psoraleae, Herba speranskiae tuberculatae blood circulation promoting and blood stasis dispelling, dispel blood stasis, promotes that blood stasis absorbs; Radix Paeoniae Rubra has the merit of warming YANG activating QI to promote diuresis, detumescence; The eliminating dampness by diuresis of Rhizoma Drynariae clearing away heat and promoting diuresis, eliminates hydrops, suppresses the effect of synovial membrane abnormal secretion; Herba Lycopodii, the pain relieving of Radix Dipsaci channels sootheing and network vessel quickening, reach general rule not effect bitterly.Radix Notoginseng energy dissipating blood stasis blood, removing blood stasis stimulate the menstrual flow; Dredging arrogated to oneself by Rhizoma Chuanxiong, the up head, the descending sea of blood, is gas medicine in blood, is pain relieving panacea; Chinese angelica blood supplementing is moisturized, blood stasis dispelling of stimulating the menstrual flow; Radix Achyranthis Bidentatae, QI invigorating yin fluid astringing, help the power of the raw the moon of QI invigorating; Radix Gentianae Macrophyllae is nourshing Yin and drynsessmoistening prescription, clearing heat and relieving fidgetness; Flos Carthami medicine carrying is up, makes the efficacy of a drug up, can qi and blood circulation promotion, all medicines is grown and oiliness, mends and does not stay the stasis of blood; Zaocys is to poison the stasis of blood; Radix Aconiti Preparata removing blood stasis; All medicines share to be mended row and doublely to execute, and plays benefiting qi and nourishing yin altogether and nourishes blood, promoting flow of QI and blood pain relieving, removing the necrotic tissue and promoting granulation, and cryptomere changes and reduces, and sclerotic bone absorbs, and cartilage position is repaired, the merit of unobstructed vessel amyotrophy recovery.

Rhizoma Chuanxiong is pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Radix Achyranthis Bidentatae drug effect is high, and Li Shizhen (1518-1593 A.D.) says it: the merit of nourishing, as the power of cattle.Radix Achyranthis Bidentatae abnormal smells from the patient picric acid is put down, and cures mainly cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia unable to flex and stretch the extremities, and by vim and vigour, fire of getting mildewed in warm conditions is rotten, and clothes are made light of one's life by commiting suicide always resistance to for a long time.1. wherein contained alkaloid, has good hypotensive effect.2. the ecdysterone contained by can improve liver function, reduces plasma cholesterol, has the effect of cell activity enhancing.3. be rich in Inokopolyose and have significantly enhancing body fluid immunity function.4. pair the human body for want of low or body of gland atrophy of zinc, endocrine function that manganese causes, the pathological change such as poor growth, sexual impotence, infertile, habitual abortion has good curative effect.5. there is antiinflammatory and analgesic activity.6. have and the calculus of gallbladder, kidney, bladder, urethra is dissolved and the function excreted.7. its effective ingredient has certain excited uterus, anti-aging effects.8. diuresis, spasmolysis.So the good medicine that its blood circulation promoting and blood stasis dispelling is simply healthy and strong.

Radix Aconiti Preparata is pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.This product is many to be used after the process of preparing Chinese medicine.General in the formula of Chinese medicine, the consumption of Radix Aconiti mostly is 15-30g.Dosage is preferably not more than 60g.

The micro-hardship of Herba Lycopodii, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.Micro-hardship, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.The SHENGCAO property of medicine is standby to be wanted ": (Herba Lycopodii) " detumescence, except pathogenic wind-warm.Infusing drugs in wine is drunk, relaxing muscles and tendons and activating QI and blood in the collateral.It effects a radical cure depressed pain, damage, and internal injury caused by metallic tool, removes phlegm and relieving cough, controls skin ulcer cellulitis soldier brothers.”

Herba speranskiae tuberculatae is sweet, pungent, temperature.Enter lung, Liver Channel.Function cures mainly expelling wind and removing dampness, removing toxic substances pain relieving.For rheumatic arthritis; Sore swollen toxin is controlled in external.Join Herba Lycopodii, treating the liver kidney deficiency, muscles and bones mistake is supported, and joint stuffiness, numb limbs and tense tendons, muscles and bones contracture, has and stretch the deep effect of muscle.Join Caulis Spatholobi, the liver and the kidney tonifying, promoting blood circulation and stopping pain, it is the most suitable that lingering arthralgia belongs to empty person.

Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.The kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.The kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus." property of medicine opinion ": " five kinds of over strain six types of severe debility disease, hands is not received, upper heat and lower cold for poison in main bone, wind blood pain." " book on Chinese herbal medicine just ": " is treated bone and to be possessed poison, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism, so that the weak pain of two flaccidity of the lower limbs.

Radix Dipsaci, Chinese medicine name is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Myrrha falls apart blood blood stasis removing, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, pungent, flat.1. " property of medicine opinion ": " bitter in the mouth is pungent." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is pungent, temperature, nontoxic." 3. " Kaibao Bencao ": " and bitter in the mouth, flat, nontoxic." enter liver, spleen, the heart, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " enter spleen, kidney two warp." 3. " book on Chinese herbal medicine is looked for the truth ": " enter the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting relaxing muscles and tendons; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness are detoxified.

Olibanum is worked hard, temperature.Regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": treat edema due to wind pathogen poison swollen, remove bad odor.Treat urticaria to itch poison.Supplement to the Herbal: treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats all skin ulcers and makes internal diabetes.Control to fall and flutter injured muscles and bones: Olibanum, each Qian Wufen of true Myrrha, Radix Angelicae Sinensis, each three money of Flos Carthami, Semen Persicae.Be decocted in water for oral dose.

Radix Gentianae Macrophyllae is Gentianaceae herbaceos perennial, is one of principal agent of the diseases such as dispelling the wind and dampness pathogens arthralgia, tuberculosis hectic fever, jaundice.Especially the best in quality with the Radix Gentianae Macrophyllae of Huang Nan product in Qinghai.Be one of important Chinese medicine of China, begin to be loaded in Shennong's Herbal, be classified as middle product, " the main cold and heat pathogen of Radix Gentianae Macrophyllae, cold-damp migratory arthralgia, arthrodynia of the extremities, Xia Shui, diuresis." for rheumatic arthralgia.Radix Gentianae Macrophyllae function wind-damp dispelling, relaxing muscles and tendons network, be usually used in the diseases such as rheumatic arthralgia, joint contracture, hands and feet caused by paralysis.This product property of medicine embellishes but not dry, no matter cold-damp, damp and hot, arthromyodynia is newly of a specified duration, all can apply.In compatibility, normal being equal to Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Ramulus Mori, is used.In addition, this product is the normal and same use of expelling pathogenic wind from the body surface medicine also, the disease for the treatment of exterior syndrome limb aching pain.

Eupolyphaga Seu Steleophaga is salty, cold; Slightly poisonous.Return Liver Channel.Function cures mainly removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen." Medical Treasures of the Golden Chamber ": control the patient suffering from five overstrains being extremely weak and thin, abdominal distention, can not diet, dyspepsia, sad, impairment of fluid-retention, injury due to sexual activity, internal impairment caused by hunger, impairment caused by overstrain, meridians Rong Wei impairment of QI, blood stasis in the interior, squamous and dry skin, dark complexion around the eyes.Easing middle-JIAO and tonifying for deficiency

Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) heat-clearing and toxic substances removing, removing heat from blood suppressing the hyperactive liver.For upper respiratory tract infection, tonsillitis, pharyngitis, bronchitis, pneumonia, lung abscess, gastroenteritis, hepatitis, appendicitis, mastitis, acute conjunctivitis, hypertension; Traumatic injury is controlled in external, traumatic hemorrhage, carbuncle furuncle infections, burn and scald, venom.

Semen Strychni controls throat arthralgia pain, swollen ulcer drug, migratory arthralgia pain, fracture, facial paralysis, myasthenia gravis.1. removing obstruction in the collateral to relieve pain: by dispelling the wind and dampness pathogens insensitive impediment or contracture numbness.2, dispersing swelling and dissipating binds: with controlling wound pain caused by ecchymoma and ulcer sore pain.In recent years plant cancerous protuberance with Zhiduo County, have certain curative effect.3. treat poliomyelitis sequela, prolapse of lumbar intervertebral disc, trigeminal neuralgia, rheumatoid arthritis, traumatic injury, pain due to blood stasis, anemofrigid-damp arthralgia, general joint contracture, numbness, cancerous protuberance etc.

Sanguis Draxonis promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation, sore.Control treating swelling and pain by traumatic injury, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.Tang Materia Medica: main the five internal organs pathogen, leukorrhagia, pain relieving, removing mass blood, gold creation meat

Ramulus Sambuci Williamsii is dispeled the wind, dampness removing, invigorates blood circulation, pain relieving.Dispelling the wind and dampness pathogens bones and muscles pain, lumbago, edema, pruritus due to wind pathogen, urticaria, puerperal blood faints, treating swelling and pain by traumatic injury, fracture, wound hemorrhage.Tang Materia Medica: main injured, reuniting the fractured tendons and bones, except pruritus due to wind pathogen, dental caries.Can be bath soup.

Pheretima is salty-cold.Function heat clearing away, spasmolytic, diuresis, removing toxic substances.Cure mainly calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia.External is coated with the disease such as erysipelas, dermatitis rhus.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, numb paralysis, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Limbs paralysis; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.Good medicine of invigorating blood circulation.

Radix Paeoniae Rubra is bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Fructus Psoraleae acrid in the mouth; Bitter in the mouth; Warm in naturely return through kidney; Pericardium; Spleen; Stomach; Lung meridian function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence essence; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea." Bencao Jingshu ": Fructus Psoraleae, energy warming the kidney; Raw sun in the moon, the key medicine of excessive fire benefit soil also.Its main five kinds of strain and seven kinds of impairment, the disease of lid edge impairment caused by overstrain, a lot of in asthenia of both the spleen and kidney, with its can warming the kidney, mend fire with the immature soil, then in kidney kidney-Yang be so incensed that mend and rise, then can digesting food, steam waste matter and change precise and tiny.Spleen-QI transporting the essence to the whole body is attributed to lung, supports the five internal organs with honor, therefore the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, and the then air-cooled visitor that takes advantage of a weak point in opponent's defence so that bone marrow wound loses, the cold essence stream of kidney, and kidney governing bones store essential substances, marrow be essence this, the gas of kidney-Yang is solid, and namely, card is shown in, solid itself and yang-energy life, then front card removes in vain.Man is based on essence, and married woman is based on blood, and married woman vim and vigour person, also still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, and the cold essence stream of the kidney with man also.

Poria is sweet, light, flat.GUIXIN, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves.Cure mainly: edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.The existing treatment for hysteromyoma.For dysuria, the diseases such as edema.Poria function promoting diuresis to eliminate damp pathogen, and mild in medicine property and, diuretic and do not hinder healthy energy is promoting diuresis to eliminate damp pathogen key medicine.The disease of all dysuria, retention of water-damp, no matter be partial to cold-damp, or relatively damp and hot, or belong to insufficiency of the spleen wet poly-, all can fit applications.As relatively cold-damp person, can with the compatibility such as Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae; Relatively damp and hot person, can with the compatibility such as Polyporus, Rhizoma Alismatis; The person that belongs to deficiency of spleen-QI, can with the compatibilities such as Radix Codonopsis, Radix Astragali, the Rhizoma Atractylodis Macrocephalae; Belong to deficiency and coldness person, also can join Radix Aconiti Lateralis Preparata, the equivalent use of the Rhizoma Atractylodis Macrocephalae.

Radix Aconiti Preparata is pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.How to use after the process of preparing Chinese medicine.

Oleum Sesami is the fatty oil squeezed from Hu section plant sesame seed, and general Semen Sesami Nigrum takes, and Semen sesami Albae extracts oil.Meridian distribution of property and flavor: sweet, cool, nontoxic.Chemical composition: in Oleum Sesami, main component is unsaturated fatty acid, accounts for 85%-90%, oleic acid and linoleic acid respectively account for 50% substantially, are characterized in that stability is strong, and easily preserve, this is because containing a kind of Natural antioxidant---Semen Sesami acid in Oleum Sesami.Also containing mineral such as protein, sesamin, vitamin E, lecithin, sucrose, calcium, phosphorus, ferrum in Oleum Sesami, it is a kind of edible oil of vegetal pole horn of plenty.Effect: Chinese medicine is thought: this product nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.Record according in Compendium of Material Medica: " have moisturize, detoxify, pain relieving, detumescence merit." " not Lu " say: " sharp large intestine, afterbirth does not fall.Survivor's lump of rubbing swells, raw alopecia." clinically also decoct plaster with Oleum Sesami, there is granulation promoting meat, an effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.Containing sesamin in linum, when with siritch parch or bake dish or food, the compound of sesamin and the acid of decomposable asymmetric choice net (+) Semen Sesami and some fragrance, these fragrance matters can volatilize at normal temperatures, its aromatic flavor, elegant, tempting appetite are that other similar vegetable oil all hardly match.

Fructus Corni liver and kidney tonifying; Convergence is solid de-.Main waist is had a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Xian essence spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding; [6] interior-heat is quenched one's thirst; Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition." herbal classic ": pathogen cold and heat under the main heart, warming middle-JIAO, by cold-damp numbness, goes three worms.Lei Gong's Treatise on Preparation and Broiling of Materia Medica: primordial qi strengthening gas, secret essence.

Red sage root is used as medicine, and containing TANSHINONES, is robustness emmenagogue, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, the effectiveness such as regulating menstruation, is gynecological's key medicine, cures mainly metrorrhagia, menoxenia, blood stasis, stomachache, dysmenorrhoea, amenorrhea, mausoleum pain.Good result is had to treatment coronary heart disease.In addition also control the weak insomnia of nerve, arthralgia, anemia, mastitis, lymphadenitis, arthritis, furuncle pain is swollen, erysipelas, acute, chronic hepatitis, nephropyelitis, traumatic injury, advanced schistosomiasis hepatosplenomegaly, epilepsy.External can wash dermatitis rhus again." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Exorcising stays heat, takes sharp people for a long time.

Cortex Acanthopancis is used for rheumatic arthralgia, soreness of waist and knee joint.This product function wind-damp dispelling, again can invigorating the liver and kidney, bone and muscle strengthening." herbal classic ": main trusted subordinate's hernia, stomachache, QI invigorating is treated and is sprained, and children's can not go, the erosion of the vulva of cellulitis skin ulcer." Bencao Jingshu ": Cortex Acanthopancis, sees " herbal classic " institute and lead all cards, all because of wind-cold damp pathogen hinder in (foot few the moon, the moon of fainting) two warps therefore, and dampness is particularly the most also." warp " cloud, hinders in wet person, lower first by it.Cloud again, water-damp from the earth, feels the flesh tendon that then victimizes.Liver and kidney occupies lower and main muscles and bones, therefore the heresy that wind and cold is wet, how to be subject to through first from two, the pungent wind that can fall apart of this medicine, and temperature can except cold, bitter can dampness, two dirtyly obtain its gas and all cards know recover.Dampness contamination again, then the five internal organs muscle moderate pulse is indulged; During dampness stays, then empty gas of winning is weary.Damp was both gone, then in Jiao control and muscles and bones from hard, gas day by day and in also self-complementary.The strong will person of its main benefit essence, the kidney storing the essence and will also." not Lu ": treat man's impotence, wet under capsule, dribbling urination, woman's pudendal pruritus and pain along the spinal column, bipod pain numbness wind be weak, and five slowly emptyly to win, invigorating middle warmer benefit essence, hard muscles and bones, Qiang Zhiyi.

Herba Erodii Classification system Geranium wilfordii Maxim. dispels the wind, and invigorates blood circulation, heat-clearing and toxic substances removing.Dispelling the wind and dampness pathogens pain, contracture is numb, carbuncle, traumatic injury, enteritis, dysentery." the southern regions of the Yunnan Province book on Chinese herbal medicine ": all wind skin of dispelling is itched.Control bones and muscles pain, phlegm-fire flaccidity is soft, brothers' clonic spasm of the muscle, and numb, diuresis, rushes down bladder accumulated heat, attacks loose all pyogenic infections from tumour or sore, moves back consumptive disease heat fever, controls wind-fire dental caries, the diseases such as varioliform exanthema mange." detailed outline is picked up any lost article from the road ": remove wind, dredges through invigorating blood circulation, muscle reinforcing and bone strengthening, dredging collateral arteries and veins.Control damage, arthromyodynia, numb, Pi Feng, infusing drugs in wine is often drunk.

Radix Saposhnikoviae nature and flavor: acrid in the mouth; Sweet; Slightly warm in nature, returns urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of." Japan hanako materia medica ": control wind as 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, and arresting lacrimation and paralysis delay, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." Changsha medicine solution ": network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, relaxing muscles and tendons arteries and veins, stretches anxious twin, and podomere of living, rises paralysis, hold back spontaneous perspiration, night sweat, break, metrorrhagia.

Herba Epimedii is Chinese conventional Chinese medicine, and have very high medical value, nourishing YIN and invigorating YANG, tonifying YANG is kept fit.Bitter and puckery flavor, suitable insomniac uses.Kidney invigorating and YANG supporting, expelling wind and removing dampness.Control sexual impotence erectile problem, hemiplegia is unsuccessful, dribbling urination, and muscles and bones contraction is anxious, and cough, optic atrohic blindness after being ill, toothache caused by fire of deficiency type, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless." herbal classic ": main impotence is hindered absolutely, pains in the penis.Diuresis, physical strength profiting, Qiang Zhi." not Lu ": hard muscles and bones.Disappear scrofula, red carbuncle; Skin ulcer is arranged at bottom, washes, and goes out worm." Japan hanako materia medica ": control all cold wind consumptive disease, mend waist knee joint, heart tonifying power, husband is exhausted, and sun does not rise, the exhausted cloudy loss of fecundity of woman, and muscles and bones contraction is anxious, and extremity are not appointed, and old man's dusk octogenarian, the middle age is forgetful.

Its nature and flavor of Ramulus Cinnamomi are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if menthocamphorate, rheumatism wet goods are all containing cassia oil composition.Cure mainly " Sullfortrone " leprous its main component and cassia oil, other side-product of Cortex Cinnamomi has different pharmacological actions as Ramulus Cinnamomi, Fructus cinnamomi japonici, Fructus cinnamomi immaturus, osmanthus cup etc., widely applies in Chinese medicine.

Radix Angelicae Dahuricae acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose.There is expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidify sensible, effect of detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, venom.

Radix Notoginseng is mainly distributed in the ground such as Yunnan, Guangxi, Jiangxi, Sichuan.Radix Notoginseng is used as medicine with its root, its its warm in nature, acrid in the mouth, there is scattered silt hemostasis, effect of subduing swelling and relieving pain, and the flavone compound in Radix Notoginseng has the effect, sitosterol and the blood fat reducing of daucosterol energy that improve blood supply of cardiac muscle, increase vessel wall elasticity, coronary artery dilator.Normal food Radix Notoginseng, has preventive and therapeutic action to coronary heart diseases and angina pectoris.Just be acknowledged as since ancient times and there is significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, there is the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Excavating in season in winter in spring two because being everlasting, being divided into again " spring seven " and " winter seven ".Because Radix Notoginseng is all panax species, and its effective active matter higher than with more than Radix Ginseng, be therefore called " king in ginseng " by modern Chinese medicine medicine scholar again.Record in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, Radix Notoginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", be namely that primary raw material medicine is made with Radix Notoginseng.Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.

Rhizoma Et Radix Notopterygii property is pungent, bitter in the mouth, temperature.Return bladder, kidney channel.Function cures mainly cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.For anemofrigid cold, headache body pain.The pungent temperature of this product, gas is male and fall apart, deliver power strong, the heresy of main loose Taiyang channel ailment said due to cold or exposure and cold-damp, have cold expelling to dispel the wind, the merit of removing dampness to relieve pain, therefore kindly control wind-cold damp pathogen and attack table, fever with aversion to cold, flesh table is lossless, headache stiffness of the nape, limb aching pain person, the same use of medicine such as normal and Semen Persicae, Rhizoma Et Radix Notopterygii, Radix Clematidis, Rhizoma Chuanxiong, as Notoptreygium Decoction of Nine Ingredients; If cold-damp lays particular stress on, headache body severe one, can the medicine such as compatibility Radix Angelicae Pubescentis, manuscript, Rhizoma Chuanxiong, as Decoction of Notopterygium for Rheumatism.Rhizoma Et Radix Notopterygii tanginess manufactures the good volatile oil of drop pill.

Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.

Scorpio is pungent, flat; Poisonous.Return Liver Channel.Function cures mainly endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Scorpion extraction liquid is in mouse tumor experiment, answer 0.2ml (suitable crude drug 0.04g/ only), every large subcutaneous administration after continuous 5 days, when medication the 11st day and drug withdrawal 8 days, be 38.8% and 55.5% to the suppression ratio of cell sarcoma (SRS) solid tumor; To MA 1 breast carcinoma, administration every day is after totally 12 times, and suppression ratio is 51.8%, is 30.4% during drug withdrawal 8 days.To the survival rate comparatively matched group prolongation 12.5%-20.7% of SRS ascitic type band tumor Mus.Result shows there is obvious inhibitory action to the tumor growth of mice with tumor.The Heal complete cell death of Scorpio extract In vitro culture takes off wall.29.2% is extended to LA 1 adenocarcinoma of lung mice with tumor life span.Buthus martensii karshi tail gavage, prevention administration group S180 sarcoma suppression ratio is 45%, and therapeutic administratp group S180 sarcoma suppression ratio is 47.6%, shows that it has preventive and therapeutic action concurrently.

Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs." Kaibao Bencao ": main all wind, Xuan Tongwu hides, and go in abdomen cold stagnant, septum cordis expectorant water amasss for a long time, lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, the cold pain of waist knee joint and treatment injured.

Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of." herbal classic ": main large dizziness due to wind pain, aversion to wind, ailment said due to cold or exposure, order blindness, is in fashion the whole body, arthralgia numbness, stuffy sensation with restlessness." Japan hanako materia medica ": control wind as 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, and arresting lacrimation and paralysis delay, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse.

Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." Bencao Jingshu ": Herba Taxilli, its bitter but sweet flavor, its gas is gentle, cold not hot, admittedly should be nontoxic.It cures mainly in detail, take out its elite for one, therefore function compares Sang Yousheng in Mulberry.Lumbago and children's's stiffback, all time of insufficiency of blood, carbuncle is many due to ying-qi heat.Skin does not fill, due to blood deficiency.Tooth person, originator, beneficial blood then sends out China after blood also, and the sufficient then tooth of kidney qi is hard and an eyebrow is long after bone also.Blood contains then tire peace certainly.Woman's metrorrhagia and internal injury deficiency, all events of blood deficiency interior-heat.Disease more than puerperal, all by blood system, agalactia, also by blood deficiency.Incised wound is then hindered entirely in blood.To come up all diseases, there's no one who doesn't or isn't know and have heat institute to send out by blood deficiency, this property of medicine can beneficial blood, thus also lead also.Hold concurrently and can wet by core, therefore also treat numbness.

Radix Tripterygii Wilfordii, cry again Caulis Fibraureae, beeswax rattan, cabbageworm medicine, red medicine, water Folium illicii Lanceolati, Classification system: Tripterygium wilfordii Hook.f. is the root of Celastraceae, tripterygium plant Radix Tripterygii Wilfordii, liana shrub, main product in Fujian, Zhejiang, Anhui, the ground such as Henan.In being born in the shade many wet hillside, mountain valley, small stream limit bushes.The hillside that happiness is comparatively shady and cool, the sand soil deep with slant acidity, soil layer or the most suitable growth of yellow soil.Bitter in the mouth, pungent, cool in nature, poison greatly.Return liver, kidney channel.Effect expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, reducing swelling and alleviating pain, solution poisoningworm.For damp and hot tuberosity, the long-pending poison of carcinoma, treat lepra reaction, rheumatoid arthritis etc. with it clinically, have the effect such as antitumor, antiinflammatory.

Cortex Illicii Classification system Illicium difengpi K.L.B.et K.I.M. belongs to Magnoliaceae can treat rheumatic arthritis; Lumbar muscle strain; Centipete bite, " Xinhua's book on Chinese herbal medicine outline ", bark: acrid in the mouth, puckery, warm in nature, slightly poisonous.There is evil-wind expelling and dampness removing, the function of promoting the circulation of QI to relieve pain.Bark: acrid in the mouth, puckery, warm in nature, slightly poisonous.There is evil-wind expelling and dampness removing, the function of promoting the circulation of QI to relieve pain.Chemical composition of Chinese materia medica: bark is containing volatile oil 0.3 one 0.71%, and in oil, composition is 28 kinds of compositions such as a mono-pinene, B mono-pinene, camphene, myrcene, cineole, linalool, Camphora, Radix Gentianae, ethyl acetate, safrole, cedrol.

Catechu is bitter, puckery, is slightly cold.Heat clearing away, promotes the production of body fluid, and reduces phlegm, sore, hemopoietic.For watery diarrhea, endo-enteritis, oral cavity ulceration, eczema, cough, knife injury is hemorrhage.Catechu aqueous solution can suppress the wriggling of duodenum in rabbit and small intestinal, and can promote the retrostalsis of caecum, and has anti-diarrhea effect; But large intestine is not almost acted on.Catechu has in vitro and stronger kills ascites cells effect.Catechu decoct all has inhibitory action to staphylococcus aureus, diphtheria corynebacterium, Bacillus proteus, shigella flexneri and Bacillus typhi; Also inhibitory action is had for common therapeutic dermatophytes.The extract of its leaf all has inhibitory action to staphylococcus aureus, escherichia coli.

The manufacturing process of the present invention's honey refining pill is:

Get Poria 1000g, Radix Salviae Miltiorrhizae 1000g, Fructus Corni 1000g, Cortex Acanthopancis 1000g, Rhizoma Chuanxiong 1000g, Radix Gentianae Macrophyllae 1000g, Herba Taxilli 1000g, Radix Achyranthis Bidentatae 1000g, Flos Carthami 1000g, Eupolyphaga Seu Steleophaga 1000g, Caulis Spatholobi 1000g, Rhizoma Drynariae 1000g, Rhizoma Polygoni Cuspidati 1000g, Fructus Psoraleae 1000g, Ramulus Sambuci Williamsii 1000g, Herba Lycopodii 1000g, Ramulus Cinnamomi 1000g, Pheretima 1000g, Radix Paeoniae Rubra 1000g, Herba Erodii 1000g, Radix Saposhnikoviae 1000g, Herba Epimedii 1000g; The crude drug medical material getting above-mentioned ratio of weight and number soaks 1 hour, is then placed in multi-function extractor, and first time decocts 10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 75 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 65 DEG C; Put into baking oven, control at 75 DEG C, after drying, cooling, mixes with Mel and is twisted into slice, and wax seal is packed.

This gelatinthe manufacturing process of wafer is: get Poria 1200g, Radix Salviae Miltiorrhizae 1100g, Fructus Corni 1200g, Cortex Acanthopancis 1200g, Rhizoma Chuanxiong 1200g, Radix Gentianae Macrophyllae 1100g, Herba Taxilli 1200g, Radix Achyranthis Bidentatae 1200g, Flos Carthami 1200g, Eupolyphaga Seu Steleophaga 1200g, Caulis Spatholobi 1200g, Rhizoma Drynariae 1100g, Rhizoma Polygoni Cuspidati 1200g, Fructus Psoraleae 1200g, Ramulus Sambuci Williamsii 1200g, Herba Lycopodii 1200g, Ramulus Cinnamomi 1200g, Pheretima 1200g, Radix Paeoniae Rubra 1100g, Herba Erodii 1200g, Radix Saposhnikoviae 1200g, Herba Epimedii 1200g, put into 10 times amount ethanol, heating and refluxing extraction 1 hour, extracts active ingredient, is left standstill by extracting solution.Get medicinal residues that ethanol extraction crosses to add water heating and refluxing extraction 3 times, each 30 minutes ~ 45 minutes, 3 extracting solution are merged and leaves standstill.Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.07; Above-mentioned filtrate is the macroporous adsorptive resins absorption of 10L through volume; With the deionized water of 10 times of resin column volumes or distilled water eluting after absorption, then use the ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.Every capsules dress 0.3g.Can every 12 be one edition.

The manufacturing process of Tablets is:

Get Poria 1200g, Radix Salviae Miltiorrhizae 1100g, Fructus Corni 1200g, Cortex Acanthopancis 1200g, Rhizoma Chuanxiong 1200g, Radix Gentianae Macrophyllae 1100g, Herba Taxilli 1200g, Radix Achyranthis Bidentatae 1200g, Flos Carthami 1200g, Eupolyphaga Seu Steleophaga 1200g, Caulis Spatholobi 1200g, Rhizoma Drynariae 1100g, Rhizoma Polygoni Cuspidati 1200g, Fructus Psoraleae 1200g, Ramulus Sambuci Williamsii 1200g, Herba Lycopodii 1200g, Ramulus Cinnamomi 1200g, Pheretima 1200g, Radix Paeoniae Rubra 1100g, Herba Erodii 1200g, Radix Saposhnikoviae 1200g, Herba Epimedii 1200g; First all crude drug are cut into coarse granule, then put into ethanol, soak more than 2-5 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, concentrated 30 minutes ~ 45 minutes of heating, be concentrated into extractum shape, stand for standby use, become component 1.Again the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.Finally above-mentioned two kinds of component extractum are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.1g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 80 DEG C 1.38; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain crude drug medicated powder dress, tablet made by mixing starch tabletting.

The preparation method of externally used paste of the present invention comprises:

First by Radix Notoginseng 1500g, Sanguis Draxonis 1500g, Olibanum 1500g, Myrrha 1500g, Cortex Cinnamomi 1500g and the Rhizoma Et Radix Notopterygii 1500g way of distillation are vaporized into crystallization, pulverize for subsequent use, get above-mentioned Cortex Illicii 1500g again, Radix Dipsaci 1500g, Flos Carthami 1500g, Semen Strychni 1500g, catechu 1500g, Radix Aconiti Preparata 1500g, Cortex Cinnamomi 1500g, Herba speranskiae tuberculatae 1500g, Radix Angelicae Dahuricae 1500g, Radix Tripterygii Wilfordii 1500g, Radix Clematidis 1500g, Pheretima 1500g, Scorpio 1500g, crude drug medical material is added in the Oleum Sesami of 10 times of weight portions and soak 7-10 days, heating extraction effective ingredient, big fire is boiled, after Oleum Sesami boiling, firepower reduces, endure to pharmaceutical presentations be dark brown, inner coke yellow, pull medicinal residues out, medicine oil is continued to temper, and constantly stir, cigarette is by Bai Zhuanqing, refining is to dripping into pearl, Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity, slowly added by Plumbum preparatium in the medicine oil refined, constantly stir, become the thick paste of black, the plaster refined mixes the vaporization crystalline particle of pulverizing, in slightly cold rear impouring cold water, soaks 5-10 days, changes water every day once, releasing fire-toxin.

The preparation method of medicinal external emulsifiable paste agent of the present invention comprises:

First Radix Notoginseng 1500g, Sanguis Draxonis 1500g, Olibanum 1500g, Myrrha 1500g, Cortex Cinnamomi 1500g and the Rhizoma Et Radix Notopterygii 1500g way of distillation are vaporized into crystallization, pulverize for subsequent use, again by all the other crude drug medicine Cortex Illiciis 1500g, Radix Dipsaci 1500g, Flos Carthami 1500g, Semen Strychni 1500g, catechu 1500g, Radix Aconiti Preparata 1500g, Cortex Cinnamomi 1500g, Herba speranskiae tuberculatae 1500g, Radix Angelicae Dahuricae 1500g, Radix Tripterygii Wilfordii 1500g, Radix Clematidis 1500g, Pheretima 1500g, Scorpio 1500g, add and account for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; Then the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use; Finally above-mentioned 2 kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, adds the crystalline powder prepared, and the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste shape.

Pharmacological toxicity is tested

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: Tablets, containing 0.0365g crude drug/sheet

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve tablet adding distil water, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Tablet adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: aggregate toxicity is tested:

The agent of Chinese medicine preparation of the present invention honey refining for oral administration pill presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation oral capsule of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Experimental example 3: acute dermal toxicity result of the test

Medicine externally used compound preparation of the present invention, has expelling wind and removing dampness, and effect of promoting blood circulation to remove obstruction in the collateral is used for the treatment of the disease such as rheumatism, rheumatoid arthritis.Accordingly, first carry out acute dermal toxicity test, to observe this medicine to the nontoxic level in the whether true border of rat acute percutaneous toxicity.

Tested material: the preparation ointment of external of the present invention.Weighing tested material 50g adding distil water, to make 50% pastel for subsequent use.

Laboratory animal: provide SD rat 20 by Medicine Institute, Shandong Province Experimental Animal Center, male and female half and half, body weight 180-220g, primary animal (dynamic No. 08-25th, the word of doctor), feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%, the Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test first 24 hours, in back part of animal spinal column both sides unhairing, unhairing scope is about body surface area 10%.By the dosage (coating amount 1.0g/100g.bw) of 5000mg/kg.bw, examination Mus unhairing position is applied and fixed, after 24 hours, the residual tested material of warm water removing, Continuous Observation 7 days.Result of the test: have no examination Mus whole body ANOMALOUS VARIATIONS in the observation period, also have no dead, is coated with the reactions such as tested material local has no red and swollen, festers, inflammation, necrosis.These results suggest that this medicine is to the nontoxic level in the true border of rat acute percutaneous toxicity.

Experimental example 4: repeatedly Skin Irritation Test result

According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", repeatedly Skin Irritation Test is carried out to medicine of the present invention.

Tested material: liniment of the present invention.Weighing tested material 50g adding distil water, to make 50% pastel for subsequent use.

Laboratory animal: provide Japanese white big ear rabbit 4 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 2.5-3.0kg, primary animal (dynamic No. 08-018th, the word of doctor), feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Only get tested material 0.5g/, be coated in after preparation on the skin of every rabbit side, smear every day once, offside all makes solvent control.Smear 14d continuously.Cropping before being coated with every day, must not injured skin, ensures that tested material fully contacts with skin.Observe dermoreaction and marking every day.Off-test, gets and smears area skin and carry out histopathologic examination.

Experimental result: repeatedly Skin Irritation Test shows that repeatedly the highest stimulation index of skin irritation and pathological tissue integration are 0 in the present invention, according to skin irritation strength grading standard in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the present invention repeatedly skin irritation intensity belongs to nonirritant.

Experimental example 5, skin anaphylactic test

According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", skin anaphylactic test is carried out to medicine of the present invention.

Tested material: liniment of the present invention.Weighing tested material 10g adding distil water, to make 50% pastel for subsequent use.Positive control: 2,4-dinitro-chloro-benzene, produce in Xing Jin chemical plant, Beijing, lot number 20020522.Laboratory animal: provide Cavia porcellus 30 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 250-300g, primary animal, feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test Cavia porcellus is divided into three groups at random, often organize 10, male and female half and half, are respectively tested material group, negative control group and positive controls.

Sensitization contact: removed by guinea pig back left of spine hair for first 24 hours to tested material, unhairing scope is about 3cm × 3cm.Get tested material 0.2g/ only, be coated in district of losing hair or feathers on the left of back part of animal after preparation, continue 6 hours.7th day and the tenth four days, repeat once with same method, positive controls is coated with 1%DNCB, and negative control group does not deal with.Excite contact: after last is to tested material ten four days, by tested material 0.2g/ only, be coated on district of losing hair or feathers on the right side of guinea pig back after preparation, remove tested material after 6 hours, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hour.Positive controls is coated with 1%DNCB, and negative control group does not deal with.Observational technique is with tested material group.

Result of the test: skin anaphylactic test shows patch of the present invention, according to according to sensitization of skin intensity evaluation standard relevant in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the invention belongs to without sensitization.

Experimental example 6, anti-inflammation test, analgesic test, microcirculation test

Anti-inflammation test: tested group of mouse ear inflammation swelling is less than blank group, and difference has significance (P<0.05), illustrates that patch of the present invention has certain antiinflammatory action.Analgesic test: tested group of mouse writhing number of times reduces than blank group, and difference has significance (P<0.05).Illustrate that patch of the present invention has certain analgesic activity.

Microcirculation test: tested group of Mice Auricle fine motion, vein bore and capillary vessel number all comparatively blank group obviously increase, and difference all has highly significant (P<0.01), illustrate that patch of the present invention has and improve the microcirculatory effect of Mice Auricle.

Clinical drug effect explanation

Material and method

1, laboratory animal

Wistar adult rat (being provided by Academy of Medical Sciences institute of lab animals of University Of Qingdao), male totally 54, body weight 220 ~ 260g.Often criticize 12, raise with the same cage of group (6, every cage) in test, receptacle temperature 20 ~ 24 DEG C, give granule Mus feedstuff, in test, free drinking water and food, quantity-unlimiting.

2, medicine

The inventive samples medicinal liquid preparation prepared by the method for embodiment 2: make containing 2% solution of the present invention with 5% Arabic glue.

3, fracture model makes

Rat is with 5% chloral hydrate (0.15ml/100g) intraperitoneal injection, anaesthetize successfully, left hind shank is shaved the conventional iodine tincture ethanol of hair and is taken off iodine sterilization, select outside longitudinal incision under left tibia tuberosity, be about 2.5cm, cut skin to subcutaneous, do not hinder subcutaneous superficial vein as far as possible, cut tibialis, be bluntly separated to tibia, be separated around week along medial tibial periosteal, inner side is toe side extensor separately, note not hindering arteria saphena, anterior tibial artery and neural accordingly, saw cross-section tibia with little Bao, traverse point is about 1cm place under tibial tuberosity.Before sewing up sarolemma, subcutaneous and skin is sewed up in the reduction of the fracture, is above-knee 2cm and fixes to toes point plaster cylinder, remove after 7 days with Gypsum Fibrosum (6 layers) gauze.

4, grouping and medicine feed

Above-mentioned model mouse is divided at random: A group ~ fracture of taking medicine group: by sample 0.5ml/100g for oral administration (method of defined of " converting dose,equivalent ratio table by body surface area between humans and animals " is shown in the pharmacological experimental methodology second edition in dosage measuring and calculating), with Mus irrigation stomach device medicine feed every day once.Anesthesia after waking up at once first time medicine feed, continuously to fixed the date.B group ~ simple fracture group (matched group): every daily Mus irrigation stomach device feeds 5% Arabic glue of respective amount once, continuously to fixed the date.One of C group ~ 28 day group: be take medicine after fracture 14 days, drug withdrawal 14 days groups.This group does not get blood, only does hypophysis pathologic finding.

5, get blood and survey Serum GH concentration

Above-mentioned three groups of test rats, respectively at after fracture 3,7,14,28 days clear-headed in four batches time broken end get blood, often only get blood 10ml, natural coagulation, under room temperature, low-speed centrifugal (2000 revs/min) 15 minutes, gets serum and is about 2ml, be stored in-20 DEG C for subsequent use.Mus GH radio immunoassay (RIA) (test box is provided by U.S. NHPP) is adopted to measure Serum GH concentration.

6, statistical analysis

Above the data obtained PRIMER software carries out t inspection, variance analysis and q inspection.

Result:

1, rat fracture latter 3 days groups between Serum GH concentration compare (see table 1).

table 1, rat fracture latter 7 days groups between Serum GH value (ng/ml) compare

By table 1know, comparatively the equal numerical value of A group is high for A group and B group rat blood serum GH concentration B group, but between two groups Serum GH value through statistics (t inspection) no significant difference.

2, rat fracture latter 14 days groups between Serum GH concentration compare (see table 2)

3, rat fracture latter 28 days groups between Serum GH concentration compare (see table 2)

By table 3know that A group and B group rat blood serum GH concentration are through statistics (t inspection) process, have notable difference between t=2.45, P < 0.05, two groups.A group rat blood serum GH concentration obviously raises.

The effect of the present invention in osteogenesis and union of fracture

By Earlier period of inflammation reaction, macrophage cleaning after fracture occurs, namely enter the important stage of union of fracture, fibrous callus, primitiveness callus formation, finally complete union of fracture.The process of this complexity regulated and controled by many factors.Wherein growth hormone plays important effect to osteogenesis and union of fracture.Growth hormone (GH) is produced by antepituitary acidophil, secretes in the mode of pulsed, has obvious species specificity.

The present invention can stimulate insulin like growth factor (IGF-I and IGF-II) to be formed in liver, and this factor can stimulate mesenchymal cell to breed, and forms fibrocyte and myofibroblast.GH is a kind of essential mediator that bone matrix glue unit is formed simultaneously, and myofibroblast, fibroblast and various glue unit are partially formed fibrous callus in fracture.After this, in original and Secondary cases callus formation stage, playing two kinds of cell-skeletonization of most critical effect and osteoclast and GH also has substantial connection.Osteoblast can make fracture site have enough callus formation, and to recover seriality and the toughness of bone, IGF-I and IGF-II has very strong stimulation as vehicle to osteoblast.Osteoblast energy film there are I type and the II type IGF receptor of strong affinity, IGF-I and IGF-II obviously can promote the mitosis of osteocyte, affect osteoblastic differentiation, excited alkaline phosphatase activities, promote that Bone Gla protein synthesizes and strengthens the gene expression of osteonectin.After fracture, Serum GH concentration increases, and pituitary growth hormone cell (i.e. acidophil) is also in high functional status simultaneously.Above-mentioned reaction is strengthened, and promotes union of fracture.

GH, can growth promoting effects plate cell differentiation and growth to the direct effect of cartilage, and growth plate endochondral ossification is depended in the growth of bone, has confirmed that GH can cause New born formation simultaneously.GH can improve intestinal calcium absorption, excited kidney 1-α hydroxylase activity, and it increases osteocyte number.Formed bone mineral, act on higher than the former 100 times.Increase bone amount, accelerating union of bone fracture and add the rupture strength of bone strengthening, 1.25 (OH) 2D 3 is in the secondary callus formation stage simultaneously, can stimulate differentiation and the fusion of predecessor's mononuclear phagocyte of osteoclast, be beneficial to bone resorption, recover the form of collagen.

In addition, growth hormone is promoting the effect in fracture healing process still to have many situations to illustrate.Such as the mankind are from the period of maturation, and Serum GH concentration starts to decline, the later then major part or all disappear to 65 years old, and the decline of old people GH level can be considered as a kind of form of GHD (namely GH lacks), outstanding behaviours be bone density decline.Also find healing after middle-aged and elderly people fracture, healing evening in clinical position, and child's stage that Serum GH concentration is higher, after fracture, fast, the healing of healing early simultaneously.In a word, GH has important impact to each stage of the union of fracture of osteogenesis, although the complicated mechanism of union of fracture, some problem is not yet completely clear, and be also absolutely not that GH works separately, the effect of GH is indubitable simultaneously.After fracture, Serum GH concentration reduces and will be unfavorable for union of fracture, raises or maintain certain level will be conducive to or promote union of fracture.

Clinical trial:

Chinese medicine preparation in the present invention can promote the healing of fracturing.Through more than 2 years, the clinical observation of lower 1/3 fracture patient in the tibiofibula of heal to the most refractory of 100 examples, achieve significant curative effect, its acceptance rate is 90.70%.

1. clinical data: amount to case 100 example, wherein man 50 example, female 50 example; The oldest 67 years old, minimum 4 years old, average 32 years old; The course of disease is the longest 5 days, the shortest 1 hour, average 10 hours; Crush injury 32 is routine, motor-vehicle accident injury 27 is routine, get injured by a fall 21 examples, other reason causes injury 6 examples; Belong to closed fracture 34 example, open fracture 52 example; Both cross-section shape 19 examples, oblique 35 examples, spiral type 18 example, pulverizes shape 14 example.

2. Therapeutic Method and dose: after adopting operation and traditional method reduction, adopts different fixing meanss to fix according to fracture concrete condition.Start to take oral medicinal herb formulation tablet of the present invention, each oral 2-3 sheet, every day 3 times (every 8 hours 1 time) 15th is a course for the treatment of; For capsule, every 0.5g, oral 7 at every turn, every day 3 times (every 8 hours 1 time) 15th is a course for the treatment of.Taking the photograph X-ray film at treatments period, understand growth of spur situation, judging the clinical healing time in conjunction with having a medical check-up with or without callus.

3. efficacy evaluation:

1. criterion of therapeutical effect, according to 1994 country" Chinese medical disease Standardization of diagnosis and curative effect " that Department of Health issues is formulated.Excellent: than the normal healing time person that shifts to an earlier date 2 weeks or more; Good: to shift to an earlier date 1 week than normal healing time; General: the normal both 10 weeks clinical union of bone time; Extend than normal healing time, even fracture delayed union or disunion occur.All X-ray film is clapped 14 days or 21 days, 28 days in therapeutic process; As 14 days or 21 days have found that union of fracture person just no longer makes film, fuzzy according to fracture line, continuous growth of spur situation, gives a mark.Fracture line is still even widened, and make 0 score without interior external callus, fracture line fogs, and have inside and outside slight callus to make 1 score, fracture line almost disappears, and has continuous growth of spur to make 2 scores.2. therapeutic effect: in 100 examples, excellent: 56 examples, good: 32 examples, general: 8 examples, poor: 0 example, acceptance rate 91.70%.

Different parts fracture clinical statistics result (see following table):

Specific embodiment 1: consolidate certain, women, 36 years old, workman, fell down by bike because road of snowing is sliding, gets injured by a fall right wrist, swells and ache, movable function is limited is admitted to hospital.Have a medical check-up: god is clear, vital sign is normal, and right wrist swelling, tenderness, movable function is limited, audible and bony crepitus.Film making check, para-position is good to line.Namely the present invention is taken, for oral administration: Poria 12g, Radix Salviae Miltiorrhizae 13g, Fructus Corni 12g, Cortex Acanthopancis 13g, Rhizoma Chuanxiong 12g, Radix Gentianae Macrophyllae 13g, Herba Taxilli 13g, Radix Achyranthis Bidentatae 12g, Flos Carthami 13g, Eupolyphaga Seu Steleophaga 12g, Caulis Spatholobi 12g, Rhizoma Drynariae 11g, Rhizoma Polygoni Cuspidati 12g, Fructus Psoraleae 13g, Ramulus Sambuci Williamsii 13g, Herba Lycopodii 12g, Ramulus Cinnamomi 11g, Pheretima 12g, Radix Paeoniae Rubra 13g, Herba Erodii 13g, Radix Saposhnikoviae 12g, Herba Epimedii 13g; Make pill; External used medicine: Cortex Illicii 12g, Myrrha 14g, Olibanum 13g, Radix Dipsaci 13g, Radix Notoginseng 12g, Flos Carthami 13g, Sanguis Draxonis 12g, Semen Strychni 13g, catechu 12g, Radix Aconiti Preparata 13g, Cortex Cinnamomi 14g, Herba speranskiae tuberculatae 14g, Radix Angelicae Dahuricae 12g, Radix Tripterygii Wilfordii 12g, Radix Clematidis 13g, Rhizoma Et Radix Notopterygii 12g, Pheretima 13g, Scorpio 12g, the same day, local swelling is obviously disappeared, and pain obviously alleviates, and through film making check in 2 weeks of taking medicine, x-ray shows: fracture line is fuzzy, have continuous growth of spur, remove extenal fixation, right hand movable function is normal, and recovery from illness is left hospital.

Specific embodiment 2: go into business certain, man, 22 years old, traffic accident in 2012, was weighed wounded by car, caused left breast 4-8 rib fracture, fracture of rib, and through hospitalize one month, x-ray had no callus and generates; Look into patient's lusterless complexion, become thin, god is tired indigestion and loss of appetite, and feeble QI breath is short, and moderate pulse is soft, and deeply breathing a little consciously has rib fricative, in painful sickly complexion.In addition left breast follow through medicine, take Chinese medicine preparation of the present invention after fixing by doctor trained in Western medicine: Poria 12g, Radix Salviae Miltiorrhizae 13g, Fructus Corni 12g, Cortex Acanthopancis 13g, Rhizoma Chuanxiong 12g, Radix Gentianae Macrophyllae 13g, Herba Taxilli 13g, Radix Achyranthis Bidentatae 12g, Flos Carthami 13g, Eupolyphaga Seu Steleophaga 12g, Caulis Spatholobi 12g, Rhizoma Drynariae 11g, Rhizoma Polygoni Cuspidati 12g, Fructus Psoraleae 13g, Ramulus Sambuci Williamsii 13g, Herba Lycopodii 12g, Ramulus Cinnamomi 11g, Pheretima 12g, Radix Paeoniae Rubra 13g, Herba Erodii 13g, Radix Saposhnikoviae 12g, Herba Epimedii 13g; Make pill; External used medicine: Cortex Illicii 12g, Myrrha 14g, Olibanum 13g, Radix Dipsaci 13g, Radix Notoginseng 12g, Flos Carthami 13g, Sanguis Draxonis 12g, Semen Strychni 13g, catechu 12g, Radix Aconiti Preparata 13g, Cortex Cinnamomi 14g, Herba speranskiae tuberculatae 14g, Radix Angelicae Dahuricae 12g, Radix Tripterygii Wilfordii 12g, Radix Clematidis 13g, Rhizoma Et Radix Notopterygii 12g, Pheretima 13g, Scorpio 12g, make medicated wine and use, every day smears scouring.Hac nocte sumendus medicine of the present invention, after 8 hours, itch in the left front metathorax injury of patient's readme, posterior rib recovery from illness in 5 weeks of taking medicine, and appetite increases; Within 7 weeks, can sit up, eight weeks x-rays, the visible bone injury healings of CT.Within 10 weeks, layman assists walking of leaving the bed in, within 1 year, follows up a case by regular visits to, and can work.

Claims (10)

1. the Chinese medicine composition of a set a broken bone fracture, it is characterized in that, be made up of endo-medicine and external used medicine, described endo-medicine comprises the crude drug of following weight portion: 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Cortex Acanthopancis 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, Ramulus Sambuci Williamsii 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Erodii 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts,

External used medicine comprises the crude drug of following weight portion: Cortex Illicii 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Sanguis Draxonis 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, 10 ~ 20 parts, catechu, Radix Aconiti Preparata 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Scorpio 10 ~ 20 parts.

2. according to claim 1 set a broken bone fracture Chinese medicine composition, it is characterized in that, described endo-medicine comprises the crude drug of following weight portion: 10 ~ 15 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Cortex Acanthopancis 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Radix Gentianae Macrophyllae 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Rhizoma Drynariae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts, Ramulus Sambuci Williamsii 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Herba Erodii 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts,

External used medicine comprises the crude drug of following weight portion: Cortex Illicii 10 ~ 15 parts, Myrrha 10 ~ 15 parts, Olibanum 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Sanguis Draxonis 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, 10 ~ 15 parts, catechu, Radix Aconiti Preparata 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Scorpio 10 ~ 20 parts.

3. according to claim 1 set a broken bone fracture Chinese medicine composition, it is characterized in that, described endo-medicine comprises the crude drug of following weight portion: 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Cortex Acanthopancis 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Fructus Psoraleae 10 ~ 15 parts, Ramulus Sambuci Williamsii 10 ~ 15 parts, Herba Lycopodii 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Herba Erodii 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts,

External used medicine comprises the crude drug of following weight portion: Cortex Illicii 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Sanguis Draxonis 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, 10 ~ 20 parts, catechu, Radix Aconiti Preparata 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Tripterygii Wilfordii 10 ~ 15 parts, Radix Clematidis 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Scorpio 10 ~ 15 parts.

4. the Chinese medicine composition medicine of set a broken bone fracture according to claims 1 to 3, it is characterized in that, described endo-medicine dosage form: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, plaster, cream and drop; Described external drug dosage forms: unguentum, spray, liniment, ointment and emplastrum.

5. the preparation method of Chinese medicine composition of set a broken bone fracture according to any one of claims 1 to 3, it is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises:

A. all crude drug are put into ethanol heating and refluxing extraction 2 times, as component 1;

B. get the medicinal residues after above-mentioned ethanol extraction again, the heating and refluxing extraction that adds water 2 times, as component 2;

C. said components merged, spraying dry after decompression recycling ethanol, obtains medicated powder; Tablet made by mixing starch tabletting.

6. the preparation method of oral medicinal herb tablet of set a broken bone fracture according to claim 5, it is characterized in that, in described step a, first all crude drug are cut into coarse granule, then put into ethanol, soak more than 2-5 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, concentrated 30 minutes ~ 45 minutes of heating, is concentrated into extractum shape, stand for standby use, becomes component 1.

7. the preparation method of oral medicinal herb tablet of set a broken bone fracture according to claim 5, is characterized in that, in described step b, the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.

8. the preparation method of oral medicinal herb tablet of set a broken bone fracture according to claim 5, it is characterized in that, in described step c, above-mentioned two kinds of component extractum are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.1g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 80 DEG C 1.38; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain crude drug medicated powder dress, tablet made by mixing starch tabletting.

9. the preparation method of Chinese medicine composition of set a broken bone fracture according to any one of claims 1 to 3, it is characterized in that, the dosage form of described external used medicine is plaster, and its preparation method comprises:

First Radix Notoginseng, Sanguis Draxonis, Olibanum, Myrrha, Cortex Cinnamomi and the Rhizoma Et Radix Notopterygii way of distillation are vaporized into crystallization, pulverize for subsequent use; Added by other crude drug in the Oleum Sesami accounting for its 5-10 times weight portion and soak 3-5 days, heating extraction, first big fire is boiled, and after Oleum Sesami boiling, firepower reduces, enduring to pharmaceutical presentations is dark brown, and inner coke yellow, pulls medicinal residues out, continued to temper by medicine oil, and constantly stir, refining is to the beading that drips; Again Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity; Slowly added by Plumbum preparatium in the medicine oil refined, constantly stir, become the thick paste of black, in the slightly cold rear impouring cold water of the plaster refined, soak 5-10 days, change water every day once, releasing fire-toxin, the crystalline powder then mixing vaporization stirs.

10. the preparation method of the Chinese medicine composition of a set a broken bone fracture according to any one of claims 1 to 3, it is characterized in that, the dosage form of described external used medicine is ointment, its preparation method comprises, first Radix Notoginseng, Sanguis Draxonis, Olibanum, Myrrha, Cortex Cinnamomi and the Rhizoma Et Radix Notopterygii way of distillation are vaporized into crystallization, pulverize for subsequent use; Again all the other crude drug are added and account for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; Then the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use; Finally above-mentioned 2 kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, adds the crystalline powder prepared, and the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste shape.