CN104474114A - Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition Download PDF

Info

Publication number
CN104474114A
CN104474114A CN201410699302.2A CN201410699302A CN104474114A CN 104474114 A CN104474114 A CN 104474114A CN 201410699302 A CN201410699302 A CN 201410699302A CN 104474114 A CN104474114 A CN 104474114A
Authority
CN
China
Prior art keywords
parts
radix
rhizoma
chinese medicine
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410699302.2A
Other languages
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qingdao Shen Da New And High Technology Development Corp Ltd
Original Assignee
Qingdao Shen Da New And High Technology Development Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingdao Shen Da New And High Technology Development Corp Ltd filed Critical Qingdao Shen Da New And High Technology Development Corp Ltd
Priority to CN201410699302.2A priority Critical patent/CN104474114A/en
Publication of CN104474114A publication Critical patent/CN104474114A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • A61K36/126Drynaria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/37Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487Psoralea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and a preparation method of the traditional Chinese medicine composition. Oral medicine comprises: astragalus membranaceus, poria, prepared fleece flower root, gentiana macrophylla, radix rehmanniae preparata, dipsacus asperoids, codonopsis pilosula, achyranthes bidentata, cassia twig, radix angelicae pubescentis, parasitic loranthus, cinnamon, polygonum cuspidatum, eucommia ulmoides, rhizoma cibotii, beefwood-like clubmoss herb, drynaria rhizome, salviae miltiorrhizae, Erodium stephanianum Willd, red peony root, corydalis tuber, ground beeltle and fructus psoraleae; external medicine comprises: myrrh, resina draconis, dipsacus asperoids, notopterygium root, safflower, homalomena occulta, tripterygium glycosides, fennel, radix aconiti preparata, scorpio, garden balsam stem, polygonum cuspidatum, nux vomica and zaocys dhumnade. The traditional Chinese medicine composition is orally taken and externally paved to ensure the functions of replenishing the vital essence and removing heat, dredging the collaterals by resolving damp, relieving pain, promoting blood circulation to remove blood stasis, expelling wind and removing cold, removing swelling and relieving pain, and strengthening tendons and bones. The traditional Chinese medicine composition has a strong recovery effect on back pain and lumbar muscle strain. The traditional Chinese medicine composition is convenient to administrate, is capable of directly acting on the lesion, strong in targeting, low in cost and the like, the medicine is easy to prepare, and the traditional Chinese medicine can treat both symptoms and root causes and is safe and effective, and the treatment cost is low.

Description

A kind ofly treat Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind ofly treating Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain and preparation method thereof.
Background technology
Lumbar muscle strain, also known as functional lumbago, chronic lower lumbar injury, lumbar and breech myofacia inflammation etc., being the chronic traumatic inflammation of waist muscle and attachment point fascia or periosteum in fact, is one of common cause of lumbago, cardinal symptom is waist or lumbosacral region distending pain, aches, recurrent exerbation, pain can change, as fatigue in the daytime increases the weight of with climate change or tired degree, heavy time light when can alleviate after rest, for common clinical, frequently-occurring disease, pathogenic factors is more.It accumulates over a long period, and can make myofibrosis, even tear on a small quantity, forms cicatrix, fiber rope bar or adhesion, leaves over long-term chronic lumbago and backache.。
Mostly the cause of disease is by after acute lumbar muscle sprain and prolonged and repeated lumbar muscle strain.Or treatment not in time, processing method is improper.. prolonged and repeated excessive waist movement and over load, as seat over a long time, for a long time station or from position of bending over to the hand-held weight of orthostatism, lift thing, psoas muscle all can be made to be in high-tension state for a long time, can chronic lumbar muscle strain be caused in the course of time.Chronic lumbar muscle strain and weather, environmental condition also have certain relation, and the too low or humidity of temperature too mostly can inspire or increase the weight of lumbar muscle strain.
Clinical manifestation exists: 1. waist is ached or distending pain, part twinge or causalgia.2. increase the weight of during fatigue, alleviate during rest; Alleviate when suitable activity and often change position, hyperkinesia increases the weight of again.3. the work of bending over can not be adhered to.Often be forced to straighten one's back constantly or hit waist with alleviating pain with fist.4. waist has pressure pain point, how at musculus sacrospinalis place, and musculus sacrospinalis stop place or transverse process of lumbar vertebra place behind ilium ridge rear portion, rumpbone.5. waist profile and activity how without exception, also without obvious psoas muscle spasm, the activity of small number of patients waist is slightly limited.Flank pain: most of patients has the pain history of several weeks or several months, or have lumbago history of attack repeatedly.Lumbago degree weight differs, and severe patient can affect and stand up and sitting.After general rest, symptom alleviates, cough, sneeze or stool time firmly, all can make that the pain increased.Symptom two, lower limb radiating pain: lower limb sciatic nerve territory, side radiating pain is the cardinal symptom of primary disease, lumbago of being everlasting disappears or occurs when alleviating.Pain, by buttocks, is radiated on rear side of sub-thigh, little leg outer side gradually, and outside the developed into instep had, heel or vola, impact is stood and walked.If protuberance is in central authorities, then in cauda equina nerve symptom, the outstanding then radiation of bilateral may be bilateral or alternately.Symptom three, waist moving obstacle: waist activity all effected in every respect, it is obvious for stretching obstacle after outstanding.Small number of patients is obviously limited when anteflexion.Symptom four, scoliosis: most of patients has lumbar spine lateral bending in various degree.Convex direction, side can show the position of outthrust and the relation of nerve root.
Kidney yang deficiency syndrome lumbar muscle strain shows: lumbago, weakness of the lower extremities, clear urine in large amounts, poor memory, and be afraid of cold, pulse-phase is heavy carefully unable, tongue fur is white, pale tongue.
Plain Questions of Huangdi's Internal Classic arteries and veins wants precise and tiny opinion to point out: " incapable of turning round, kidney is by exhausted for waist person, house of kidney." illustrate that suffering from a deficiency of the kidney is lumbago Etiological." seven loose rock collection lumbagos " is pointed out: " so pain have deficiency and excess point, so-called empty person, be the spiritual asthenia of qi and blood of two kidneys also, all speech deficient syndromes, all two kidneys are from sick ear.So-called real person, non-kidney man, from real, is among two waist meridians blood vessels, and the institute wet for wind and cold invades, and dodges the institute that Na files gas and hinders, and among waist internal cavity, for damp-phlegm blood stasis stagnates obstructed and be pain, demonstrate,proves to debate know and divide and rule when foundation arteries and veins.At clinical middle employing kidney tonifying, essence replenishing, blood circulation promoting and blood stasis dispelling, the treatment way treatment lumbar muscle strain of removing obstruction in the collateral to relieve pain goes out have received good clinical efficacy.
The method for the treatment of lumbar muscle strain, western medicine is thought more, and also do not have ability that the pathology of lumbar muscle strain is reversed at present, patient can only use analgesic, pain killer injection, antiinflammatory etc. to carry out relief of symptoms.But, usually emphasize that entirety treats, motherland's medical science for the treatment of must aim at the pathogenesis of disease early have research to this disease, and be longer than blood circulation promoting and blood stasis dispelling, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening traditional black plaster very good clinical therapeutic efficacy is achieved to it.
Plaster external application is excited nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in bone, makes it to return produce and absorb dynamic equilibrium, reaches and eliminates osteodynia inflammation and the object of fully recovering." Chu is sick in interior, must shape in outer ".When symptom appears in certain position of human body, according to the trend of meridians, to launch at pain in the lumbar region position and corresponding acupuncture point thereof during treatment simultaneously, and carry out cream cave combined treatment the corresponding course for the treatment of in accordance with this disease, to reach treating both the principal and secondary aspects of a disease, thoroughly cut off the object of recurrence root, external application stimulating acupoint, dredging microcirculation, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel bone Liquid Absorption, make it to return and produce and absorb dynamic equilibrium, reach and eliminate osteodynia inflammation and the object of fully recovering.Internal and external medicine can also alleviate the side reaction that Western medicine brings, thus demonstrates its advantage place.
Summary of the invention
Technical problem to be solved by this invention is, the method for the treatment of lumbar muscle strain, and western medicine is thought more, and also do not have ability that the pathology of lumbar muscle strain is reversed at present, patient can only use analgesic, pain killer injection, antibiotic medicine etc. to carry out relief of symptoms; Drug therapy generally adopted chemical drugs and Chinese patent medicine in the past, and chemical drugs is soon effective, and these medicine toxicities are comparatively large, occur that lack of appetite is indigestion and loss of appetite, nausea and vomiting, stomach discomfort after a lot of patient medication.And the application of Chinese medicine is except treating pain in the lumbar region, lumbar muscle strain; Most critical takes for a long time to be free from side effects, and blood circulation promoting and blood stasis dispelling of the present invention, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening, can also alleviate the side reaction that Western medicine brings, thus demonstrate its advantage place.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of kidney yang deficiency syndrome lumbar muscle strain, be made up of endo-medicine and external used medicine, described endo-medicine comprises the crude drug of following parts by weight: the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Radix Dipsaci 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Cortex Eucommiae 10 ~ 20 parts, Rhizoma Cibotii 10 ~ 20 parts, Lycopodium casuarinoides Spring 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts,
External used medicine comprises the crude drug of following parts by weight: Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Zaocys 10 ~ 20 parts.
The Chinese medicine composition of described treatment kidney yang deficiency syndrome lumbar muscle strain, the crude drug of following parts by weight can be comprised: the Radix Astragali 10 ~ 15 parts in endo-medicine described in it, 10 ~ 15 parts, Poria, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Radix Gentianae Macrophyllae 10 ~ 15 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Radix Dipsaci 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Cortex Eucommiae 10 ~ 20 parts, Rhizoma Cibotii 10 ~ 20 parts, Lycopodium casuarinoides Spring 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts,
The crude drug of following parts by weight can be comprised: Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts in external used medicine, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 15 parts, Radix Tripterygii Wilfordii 10 ~ 15 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Zaocys 10 ~ 20 parts.
The Chinese medicine composition of described treatment kidney yang deficiency syndrome lumbar muscle strain, the crude drug of following parts by weight can also be comprised: the Radix Astragali 10 ~ 20 parts in endo-medicine described in it, 10 ~ 20 parts, Poria, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Radix Dipsaci 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, the Cortex Eucommiae 10 ~ 15 parts, Rhizoma Cibotii 10 ~ 15 parts, Lycopodium casuarinoides Spring 10 ~ 15 parts, Rhizoma Drynariae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, geranium 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Fructus Psoraleae 10 ~ 15 parts,
The crude drug of following parts by weight can also be comprised: Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts in external used medicine, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 15 parts, Radix Aconiti Preparata 10 ~ 15 parts, Scorpio 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, Zaocys 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method treating the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain, and the dosage form of endo-medicine described in it is pill, and its preparation method comprises:
A. all crude drug are put into ethanol heating and refluxing extraction 2 times, as component 1;
B. get the medicinal residues after above-mentioned ethanol extraction again, the heating and refluxing extraction that adds water 2 times, as component 2;
C. said components merged, spraying dry after decompression recycling ethanol, obtains medicated powder; Mix Mel and be twisted into pill.
In described step a, first all crude drug can be cut into coarse granule, then put into ethanol, soak more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount ethanol heating extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum, as component 1, and stand for standby use.
In described step b, the medicinal residues that above-mentioned ethanol extraction is crossed can be added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.
In described step c, above-mentioned two kinds of component extractum can be merged, will merge in the extraction extractum suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Spraying dry, obtains medicated powder, adds Mel and is twisted into pill.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method treating the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain, and the dosage form of external used medicine described in it is plaster, and its preparation method comprises:
The crude drug of above-mentioned parts by weight is added in the Oleum Sesami accounting for its 5-10 times weight portion and soaks 3-5 days, heating extraction, first big fire is boiled, Oleum Sesami boiling after firepower reduce, endure to pharmaceutical presentations be dark brown, inner coke yellow, pull medicinal residues out, continued to temper by medicine oil, and constantly stir, refining is to the beading that drips; Again Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity; Plumbum preparatium is slowly added in the medicine oil refined, constantly stir, become the thick paste of black, in the slightly cold rear impouring cold water of the plaster refined, soak 5-10 days, change water every day once, releasing fire-toxin.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method treating the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain, and the dosage form of described external used medicine is ointment, and preparation method comprises:
A. Fructus Foeniculi, Sanguis Draxonis, Myrrha, Rhizoma Et Radix Notopterygii and the Rhizoma Homalomenae way of distillation are vaporized into crystallization, pulverize for subsequent use;
B. all the other crude drug medicines are added alcohol heating reflux and extract 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the alcohol heating and refluxing extraction that adds water 2 times;
D. merged by above-mentioned 2 kinds of extracting solution, add the crystallization prepared after decompression recycling ethanol concentrates, the glycerol that is in harmonious proportion stirs, fill after sterilization.
In described step a, first Fructus Foeniculi, Sanguis Draxonis, Myrrha, Rhizoma Et Radix Notopterygii and the Rhizoma Homalomenae way of distillation can be vaporized into crystalline particle, then be ground into fine powder for subsequent use; In described step b, all the other crude drug can be added and account for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use; In described steps d, above-mentioned 2 kinds of extracting solution can be merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, add the crystalline powder prepared, the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste.
The Chinese medicine composition of described treatment kidney yang deficiency syndrome lumbar muscle strain, its endo-medicine dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup; External drug dosage forms can be: fumigant, ointment, liniment, tincture, ointment, powder, patch, gel and spray.
Externally used paste heating of the present invention is concentrated into pasty state, and be in harmonious proportion spread on lumbago place with wine, vinegar, Mel, pasting medicine part need clean, and fixes with preservative film, medical adhesive tape.
Orally taken and externally of the present invention share energy replenishing YIN and removing heat, removing dampness dredging collateral, eliminate pain, and to be longer than blood circulation promoting and blood stasis dispelling, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening.This technology has convenient drug administration, through patient part, the advantages such as targeting is strong, and medicament is easy to manufacture, with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, without any side effects, the application of Chinese medicine is except treating lumbar muscle strain, the side reaction that Western medicine brings can also be alleviated, thus demonstrate its advantage place.Most critical takes for a long time also can not cause side effect, treatment by Chinese herbs energy treating both the principal and secondary aspects of a disease, and safely, effectively, medical expense is lower.The present invention is easy to use, and cheap, easy to use, can create good social value and economic interests.
Detailed description of the invention
Lumbar muscle degeneration belongs to motherland's medical science pain in the lumbar region or arthromyodynia category, and its cause of disease is most by the damp that is affected by the cold, and the QI-blood circulation that wound is strained and caused is smooth, and meridians are obstructed, through flow of QI being obstructed, and stagnation of QI and blood may bring about pain.Modern medicine thinks that primary disease Etiological is degenerative change and acute and chronic trauma; thus cause mechanical pressure; chemistry or inflammatory thing the dural sac at fibrous ring rear portion or the stimulation of nerve root are occurred the paraesthesia of corresponding nerve distribution area or Ipsilateral lower limb exercise limited; waist muscle anxiety or spasm increase again the pressure of intervertebral disc conversely and increase the weight of peripheral tissue edema, and symptom is occurred repeatedly.Sickness rate is high in recent years, and the age is tending towards rejuvenation, and irrational life style and special work post are also impel one of this pathogenetic cause of disease.
Lumbar muscle degeneration belongs to impediment syndrome category, and because waist is suffered from cold, the reasons such as intrusion of pathogenic wind-cold-dampness local or traumatic injury sprain and contusion, make the waist meridian qi and blood stasis of blood stagnant not smooth, " stagnation of QI and blood may bring about pain "." Yizong Jinjian bonesetting heart method main idea " cloud: " stagnation of QI-blood, for swelling as pain, should use massotherapy, and by its meridians, with the gas of logical closing, rubbing, it stops up poly-, and swollen with dissipating blood stasis knot, its trouble can be healed." simple means treatment lumbar muscle degeneration effect can not get accreditation, and comprehensive means more receives publicity.Non-operative treatment is the basic therapy of lumbar muscle degeneration, and the overwhelming majority all can be eased or cure through Comprehensive Treatment.
The traditional Chinese medical science belongs to lumbago, arthromyodynia category lumbar muscle strain one disease.Plain Questions of Huangdi's Internal Classic arteries and veins wants precise and tiny opinion to point out: " incapable of turning round, kidney is by exhausted for waist person, house of kidney." illustrate that suffering from a deficiency of the kidney is lumbago Etiological." seven loose rock collection lumbagos " is pointed out: " so pain have deficiency and excess point, so-called empty person, be the spiritual asthenia of qi and blood of two kidneys also, all speech deficient syndromes, all two kidneys are from sick ear.So-called real person, non-kidney man, from real, is among two waist meridians blood vessels, and the institute wet for wind and cold invades, and dodges the institute that Na files gas and hinders, and among waist internal cavity, for damp-phlegm blood stasis stagnates obstructed and be pain, demonstrate,proves to debate know and divide and rule when foundation arteries and veins.At clinical middle employing kidney tonifying, essence replenishing, blood circulation promoting and blood stasis dispelling, the treatment way treatment lumbar muscle strain of removing obstruction in the collateral to relieve pain have received good clinical efficacy.
Plaster external application is excited nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in bone, makes it to return produce and absorb dynamic equilibrium, reaches and diminishes inflammation and the object of fully recovering." Chu is sick in interior, must shape in outer ".When symptom appears in certain position of human body, according to the trend of meridians, to launch at its corresponding acupuncture point of either side of the small of the back during treatment simultaneously, and carry out cream cave combined treatment the corresponding course for the treatment of in accordance with this disease, to reach treating both the principal and secondary aspects of a disease, thoroughly cut off the object of recurrence root, external application stimulating acupoint, dredging microcirculation, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption, make it to return and produce and absorb dynamic equilibrium, reach and diminish inflammation and the object of fully recovering.Internal and external medicine can also alleviate the side reaction that Western medicine brings, thus demonstrates its advantage place.
Prescription of the present invention: Radix Achyranthis Bidentatae evacuation of pus, expelling pus and promoting granulation; Radix Angelicae Sinensis promoting the circulation of blood blood stasis dispelling, invigorating middle warmer gas; Rhizoma Drynariae, Fructus Psoraleae the kidney invigorating bone strengthening, continue and hinder pain relieving; Eupolyphaga Seu Steleophaga endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Radix Angelicae Pubescentis promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Rhizoma Corydalis, Radix Dipsaci, Radix Paeoniae Alba activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain; Herba Taxilli dispelling the wind and dampness pathogens arthralgia; Radix Clematidis expelling wind and dampness; Dispersing cold for relieving pain; Radix Salviae Miltiorrhizae blood-activating kidney-tonifying sun, bone and muscle strengthening, Lycopodium casuarinoides Spring, geranium wind-damp dispelling; Separate arthralgia pain; All medicines share energy eliminating stasis to stop pain, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.Function the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo." Japan hanako materia medica " carries it: control malignant boil, lose rotten meat, parasite killing.
Fructus Psoraleae acrid in the mouth; Bitter in the mouth; Warm in naturely return through kidney; Pericardium; Spleen; Stomach; Lung meridian function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence essence; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea." Bencao Jingshu ": Fructus Psoraleae, energy warming the kidney; Raw sun in the moon, the key medicine of excessive fire benefit soil also.Its main five kinds of strain and seven kinds of impairment, the disease of lid edge impairment caused by overstrain, a lot of in asthenia of both the spleen and kidney, with its can warming the kidney, mend fire with the immature soil, then in kidney kidney-Yang be so incensed that mend and rise, then can digesting food, steam waste matter and change precise and tiny.Spleen-QI transporting the essence to the whole body is attributed to lung, supports the five internal organs with honor, therefore the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, and the then air-cooled visitor that takes advantage of a weak point in opponent's defence so that bone marrow wound loses, the cold essence stream of kidney, and kidney governing bones store essential substances, marrow be essence this, the gas of kidney-Yang is solid, and namely, card is shown in, solid itself and yang-energy life, then front card removes in vain.Man is based on essence, and married woman is based on blood, and married woman vim and vigour person, also still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, and the cold essence stream of the kidney with man also.
Radix Dipsaci, Chinese medicine name is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”
Radix Rehmanniae Preparata, Chinese medicine name, has another name called Radix Rehmanniae Preparata.For the tuber of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa (Gdertn) Iibosch.ex Fisch.etMey.) forms through Processing methods.Usually with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant is through repeatedly steaming solarization, to inside and outside darkish complexion glossy, quality softness is sticky.Section use, or parch to black is used.After the process of preparing Chinese medicine, the property of medicine turns tepor by being slightly cold, and tonification strengthens, " herbal classic is met former ": " Radix Rehmanniae Preparata, false firepower steams and shines, and it is sweet for turning a hardship, is the yang aspect of yin, therefore vigour in energy the kidney invigorating." generation research, the Dihuang polysaccharide contained by Radix Rehmanniae Preparata has obvious immune antitumor activity, also have significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.
Geranium nature and flavor are pungent, bitter, flat.Gui Jing: return liver,kidney,spleen warp.Function cures mainly: wind-damp dispelling, the meridian dredging, antidiarrheal profit.For rheumatic arthralgia, numbness contracture, muscles and bones is ached, dysentery.Control bones and muscles pain, current meridians, remove all wind: fresh Herba Erodii is cleaned, and puts 100 jin in copper pot, decocts with water secondary, filter, then filtrate is concentrated into about 30 jin, add beverage wine five liang, boil ten minutes, finally add ripe Mel six jin, mixing is mixed thoroughly, boils 20 minutes, treats cold charge tank.(" Chinese medicine shape sex experience differential method " Herba Erodii cream).
Lycopodium casuarinoides Spring, rectification of name: rattan Lycopodium clavatum, has another name called: stone rattan, lycopodium casuarinoides etc., Latin literary fame: Lycopodiastrum casuarinoides (Spring) Holub ex Dixit.Expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Improving eyesight; Removing toxic substances.Cure mainly rheumatic arthralgia, lumbar muscle strain, traumatic injury, menoxenia, night sweat, conjunctivitis, nyctalopia, burn due to hot liquid or fire, sore swollen toxin." Traditional Chinese Medicine in Sichuan will " nineteen sixty version: " can relaxing muscles and tendons to promote blood circulation.Dispelling the wind and dampness pathogens arthralgia, traumatic injury, bones and muscles pain, the disease such as menoxenia and tetany.”
Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough , Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared." property of medicine opinion ": cure mainly: several pained, kills three worms, main removing blood stasis, and the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, and except cough with dyspnea, stagnation of QI, carbuncle numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison.
Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treatment scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.
Radix Angelicae Pubescentis: expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache, " book on Chinese herbal medicine is just ": " specially reason part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness, pruritus due to damp pathogen contracture." modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation; And it is not have hypotensive effect, but lasting; Contained bergapten, xanthotoxin etc. have photosensitive and antitumor action.Anemofrigid-damp arthralgia.The pungent loose hardship of these product is dry, and the fragrant temperature of gas is logical, and merit is apt to Eradicates rheumatism, stopping numbness pain, is dispelling the wind and dampness pathogens arthralgia pain principal agent, the arthromyodynia that all wind-cold damp pathogens are caused, no matter for a long time new, all can apply; Enter kidney channel because it is main, property is apt to descending, is especially advisable with waist knee joint, lower limb joints of foot pain subordinate portion cold-damp person.Control the anemofrigid-damp arthralgia of the damp that is affected by the cold, muscle, back, brothers' pain, be often equal to use with Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae, as Radix Angelicae Pubescentis soup (" young new book of living "); If with compatibilities such as Herba Taxilli, the Cortex Eucommiae, Radix Ginsengs, arthromyodynia can be controlled with the passing of time weakened body resistance, soreness of the waist and knees, joint joint stuffiness person, as Radix Angelicae Pubescentis et Herba Taxilli Decoction (" prescriptions worth thousand gold ").
Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." Bencao Jingshu ": Herba Taxilli, its bitter but sweet flavor, its gas is gentle, cold not hot, admittedly should be nontoxic.It cures mainly in detail, take out its elite for one, therefore function compares Sang Yousheng in Mulberry.Lumbago and children's's stiffback, all time of insufficiency of blood, carbuncle is many due to ying-qi heat.Skin does not fill, due to blood deficiency.Tooth person, originator, beneficial blood then sends out China after blood also, and the sufficient then tooth of kidney qi is hard and an eyebrow is long after bone also.Blood contains then tire peace certainly.Woman's metrorrhagia and internal injury deficiency, all events of blood deficiency interior-heat.Disease more than puerperal, all by blood system, agalactia, also by blood deficiency.Incised wound is then hindered entirely in blood.To come up all diseases, there's no one who doesn't or isn't know and have heat institute to send out by blood deficiency, this property of medicine can beneficial blood, thus also lead also.Hold concurrently and can wet by core, therefore also treat numbness.
Radix Paeoniae Rubra nourishes blood cool in nature, and bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing receives the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Rubra decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.The condition subject such as the blood deficiency deficiency of YIN, the breast abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, dysentery stomachache, women's menalgia, spontaneous perspiration easy antiperspirant night sweat, sural spasm, spasm of the limbs pain, uneasy lower limb syndrome are suitable edible.
Ramulus Cinnamomi is used for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea. rheumatic arthralgia, shoulder arm podomere cold type of pain, normal being equal to Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, is used, with dispelling cold by warming the meridian pain relieving, as Ramuli Cinnamomi and Aconiti Praeparatae Decoction. cold syndrome of the stomach is suffered from abdominal pain, like warm pain relieved by pressing, be often equal to use with maltose, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, play the merit of warming spleen and stomach for dispelling cold altogether, as Xiao Jianzhong Tang. the cold in blood stasis of blood is stagnant, amenorrhea stomachache or dysmenorrhea, be often equal to use with Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Evodiae, with dispelling cold by warming the meridian, promoting blood circulation to restore menstrual flow, as decoction for warming channels. cardiopalmus irregularly intermittent and regularly intermittent pulse, is often equal to use with Radix Glycyrrhizae Preparata, Radix Ginseng, as zhigancao decoction.
Radix Achyranthis Bidentatae eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.For amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, and aphtha is spitted blood, epistaxis." herbal classic ": main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia can not be bent, and by vim and vigour, fire of getting mildewed in warm conditions is rotten, induced abortion." not Lu ": middle weak breath of curing the wound, male kidney yin disappears, and old man loses excessive, and invigorating middle warmer is absolutely continuous, fills out bone marrow, and except pain and pain along the spinal column in brain, married woman's moon water is obstructed, blood agglomeration, and benefit essence, Li Yin gas, only turns white." property of medicine opinion ": control impotence, kidney tonifying, essence replenishing, by stagnant blood stream knot, helps the twelve regular channels.
The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea , WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.
The Radix Astragali, can invigorating QI to consolidate the body surface resistance based on tonify deficiency, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease
Radix Gentianae Macrophyllae is Gentianaceae herbaceos perennial, is one of principal agent of the diseases such as dispelling the wind and dampness pathogens arthralgia, tuberculosis hectic fever, jaundice.Especially the best in quality with the Radix Gentianae Macrophyllae of Huang Nan product in Qinghai.Be one of important Chinese medicine of China, begin to be loaded in Shennong's Herbal, be classified as middle product, " the main cold and heat pathogen of Radix Gentianae Macrophyllae, cold-damp migratory arthralgia, arthrodynia of the extremities, Xia Shui, diuresis." for rheumatic arthralgia.Radix Gentianae Macrophyllae function wind-damp dispelling, relaxing muscles and tendons network, be usually used in the diseases such as rheumatic arthralgia, joint contracture, hands and feet caused by paralysis.This product property of medicine embellishes but not dry, no matter cold-damp, damp and hot, arthromyodynia is newly of a specified duration, all can apply.In compatibility, normal being equal to Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Ramulus Mori, is used.In addition, this product is the normal and same use of expelling pathogenic wind from the body surface medicine also, the disease for the treatment of exterior syndrome limb aching pain.
Eupolyphaga Seu Steleophaga has effect of removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Pharmacological evaluation, has the effect of dispersing swelling and dissipating binds.Cure mainly blood stasis etc. in traumatic injury, abdomen.Containing volatile oil and aminoacid.Volatile oil total amount about 22%, is mainly naphthalene, fatty aldehyde, aromatic aldehyde; Total amino acid content about 40%.Pharmacology: hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, erythrocyte aggregation index, erythrocyte mechanical fragility can be made all to reduce, make erythrocyte sedimentation rate, erythrocyte sedimentation rate constant obviously raises.In addition effects such as also having blood fat reducing, anoxia enduring, ease pain, resist myocardial ischemia.Cold in nature, salty in the mouth; Slightly poisonous.Function cures mainly: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition castering action is had to the leukopenia that chemotherapy radiotherapy causes.Radix Codonopsis is put down, sweet in the mouth, there is effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, body immunity can also be strengthened, improve the activity of superoxide dismutase, strengthen the ability eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.Contained by Radix Codonopsis, effective ingredient has excitation to nervous system, and energy enhancing body resistance, can increase erythrocyte and hemoglobin again; Zinc contained by it can enhancing development and raising sexual function.
The Cortex Eucommiae is Chinese famous and precious tonic herb.Tool invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering, many effects such as antiabortive.Shennong's Herbal is classified as top grade.Call its " cure mainly waist and knee, invigorating middle warmer, beneficial vital essence, hard muscles and bones, wet except itching under the moon, dribbling urination.Clothes of a specified duration, make light of one's life by commiting suicide always resistance to." Cortex Eucommiae is Chinese peculiar medical material, its medicinal history is long, has a wide range of applications clinical.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension." herbal classic ": " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, Qiang Zhi, wet except itching under the moon, dribbling urination.
Rhizoma Cibotii is bitter, sweet, temperature.Return liver, kidney channel.Effect: wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.Cure mainly rheumatic arthralgia, soreness of the waist and knees, weakness of the lower extremities, frequent micturition, the enuresis, leukorrhagia.External application incised wound is stopped blooding.It is strong that " herbal classic " carries its back, shutdown emergency, general arthralgia cold-damp gonalgia, quite sharp old man.Man woman poison wind weak foot, kidney qi is weak, reuniting the fractured tendons and bones, tonification man.Li Shizhen (1518-1593 A.D.) Compendium of Material Medica carries its strong Liver and kidney, and strong bone, controls wind void.
Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.Analgesic activity: Rhizoma Corydalis powder has analgesic activity, its pain relieving is tired and is about 1/100 of opium; Rhizoma Corydalis total alkaloids, Corydaline, B prime, Chou prime, Kui prime all have analgesic activity, stronger with B prime. various dosage form with alcohol extractum and powder effect strong.
Poria: ancients claim Poria to be " when four god medicine ", because its effect widely, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, wet all diseases, can play its unique effects.Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Also can be used as food materials use, have cake, Poria cocos congee, very nutritious, taste is gentle.Coordinate to boil water with the precious Ganoderma of fine jade, contribute to treating diabetes, tumor chronic diseases.
External used medicine:
Rhizoma Et Radix Notopterygii property is pungent, bitter in the mouth, temperature.Return bladder, kidney channel.Function cures mainly cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.For anemofrigid cold, headache body pain.The pungent temperature of this product, gas is male and fall apart, deliver power strong, the heresy of main loose Taiyang channel ailment said due to cold or exposure and cold-damp, have cold expelling to dispel the wind, the merit of removing dampness to relieve pain, therefore kindly control wind-cold damp pathogen and attack table, fever with aversion to cold, flesh table is lossless, headache stiffness of the nape, limb aching pain person, the same use of medicine such as normal and Semen Persicae, Rhizoma Et Radix Notopterygii, Radix Clematidis, Rhizoma Chuanxiong, as Notoptreygium Decoction of Nine Ingredients; If cold-damp lays particular stress on, headache body severe one, can the medicine such as compatibility Radix Angelicae Pubescentis, manuscript, Rhizoma Chuanxiong, as Decoction of Notopterygium for Rheumatism.Rhizoma Et Radix Notopterygii tanginess manufactures the good volatile oil of drop pill.
Fructus Foeniculi dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For Xiong Xie institute abdomen pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting, hydrocele of testis.Salt Fructus Foeniculi warming the kidney dispersing cold for relieving pain.Ramulus Cinnamomi is used for affection of exogenous wind-cold exterior syndrome, no matter there is antiperspirant, losslessly all can to apply. exterior deficiency has antiperspirant person, normal and the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae is equivalent to be used, with harmonizing yingfen and weifen, as guizhi decoction. show real person with anhidrosis, the mutual reinforcements between such as normal and Radix Polygoni Multiflori Preparata are for use, to strengthen the merit of relieving the exterior syndrome by diaphoresis, as Radix Polygoni Multiflori Preparata soup. for rheumatic arthralgia, cold syndrome of the stomach is suffered from abdominal pain, amenorrhea, dysmenorrhea. rheumatic arthralgia, shoulder arm podomere cold type of pain, normal and Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Radix Glycyrrhizae is equivalent to be used, with dispelling cold by warming the meridian pain relieving, as Ramuli Cinnamomi and Aconiti Praeparatae Decoction. cold syndrome of the stomach is suffered from abdominal pain, like warm pain relieved by pressing, normal and maltose, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens is equivalent to be used, play the merit of warming spleen and stomach for dispelling cold altogether, as Xiao Jianzhong Tang. the cold in blood stasis of blood is stagnant, amenorrhea stomachache or dysmenorrhea, normal and Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Evodiae is equivalent to be used, with dispelling cold by warming the meridian, promoting blood circulation to restore menstrual flow, as decoction for warming channels. cardiopalmus irregularly intermittent and regularly intermittent pulse, normal and Radix Glycyrrhizae Preparata, Radix Ginseng is equivalent to be used, as zhigancao decoction.
Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is amassed, or skin infection sufferings and swollenly burst uneasy, and be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted.
Myrrha falls apart blood blood stasis removing, subduing swelling and relieving pain.Cure mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Bitter in the mouth, pungent, flat.Enter liver, spleen, the heart, kidney channel." Bencao Jingshu " carries it: " ulna arthralgia and husband's breast abdomen coerce costalgia, non-retention of blood stasis and because using in blood deficiency person.Lochia goes many, and in abdomen, empty pain person should not use.Carbuncle has been burst and should not have been used.The non-heat in blood of conjunctival congestion skin nebula notably should not be used." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting relaxing muscles and tendons.
Scorpio is pungent, flat; Poisonous.Return Liver Channel.Function cures mainly endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Scorpion extraction liquid is in mouse tumor experiment, answer 0.2ml (suitable crude drug 0.04g/ only), every large subcutaneous administration after continuous 5 days, when medication the 11st day and drug withdrawal 8 days, be 38.8% and 55.5% to the suppression ratio of cell sarcoma (SRS) solid tumor; To MA 1 breast carcinoma, administration every day is after totally 12 times, and suppression ratio is 51.8%, is 30.4% during drug withdrawal 8 days.To the survival rate comparatively matched group prolongation 12.5%-20.7% of SRS ascitic type band tumor Mus.Result shows there is obvious inhibitory action to the tumor growth of mice with tumor.The Heal complete cell death of Scorpio extract In vitro culture takes off wall.29.2% is extended to LA 1 adenocarcinoma of lung mice with tumor life span.Buthus martensii karshi tail gavage, prevention administration group S180 sarcoma suppression ratio is 45%, and therapeutic administratp group S180 sarcoma suppression ratio is 47.6%, shows that it has preventive and therapeutic action concurrently.
Semen Strychni controls throat arthralgia pain, swollen ulcer drug, migratory arthralgia pain, fracture, facial paralysis, myasthenia gravis.1. removing obstruction in the collateral to relieve pain: by dispelling the wind and dampness pathogens insensitive impediment or contracture numbness.2, dispersing swelling and dissipating binds: with controlling wound pain caused by ecchymoma and ulcer sore pain.In recent years plant cancerous protuberance with Zhiduo County, have certain curative effect.3. treat poliomyelitis sequela, prolapse of lumbar intervertebral disc, trigeminal neuralgia, rheumatoid arthritis, traumatic injury, pain due to blood stasis, anemofrigid-damp arthralgia, general joint contracture, numbness, cancerous protuberance etc.
Radix Dipsaci, Chinese medicine name is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”
Radix Tripterygii Wilfordii, cry again Caulis Fibraureae, beeswax rattan, cabbageworm medicine, red medicine, water Folium illicii Lanceolati, Classification system: Tripterygiumwilfordii Hook.f. is the root of Celastraceae, tripterygium plant Radix Tripterygii Wilfordii, liana shrub, main product in Fujian, Zhejiang, Anhui, the ground such as Henan.In being born in the shade many wet hillside, mountain valley, small stream limit bushes.The hillside that happiness is comparatively shady and cool, the sand soil deep with slant acidity, soil layer or the most suitable growth of yellow soil.Bitter in the mouth, pungent, cool in nature, poison greatly.Return liver, kidney channel.Effect expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, reducing swelling and alleviating pain, removing toxic substances parasite killing.For damp and hot tuberosity, the long-pending poison of carcinoma, treat lepra reaction, rheumatoid arthritis etc. with it clinically, have the effect such as antitumor, antiinflammatory
Herba speranskiae tuberculatae, formal name used at school: Phryma leptostachyaL. has another name called distiller’s yeast grass, Staggergrass etc.Part of being used as medicine is plant herb.So that herb color is green, dry, matter is tender, free from admixture person is good.There are blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow.External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.
Rhizoma Homalomenae formal name used at school: Homalomena occulta, English name: RHIZOMAHOMALOMENAE.Araeceae Rhizoma Homalomenae belongs to herbaceos perennial.Gas is fragrant, acrid in the mouth, micro-hardship.Property pungent, temperature.Mild toxicity.Be included into liver; Kidney; Stomach warp.There is the effects such as wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving, detumescence.Can dispelling the wind and dampness pathogens arthralgia pain, podomere acid is educated, muscles and bones flaccidity is soft, traumatic injury, stomachache, carbuncle skin ulcer are swollen.
Zaocys dispels the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.Naja, Agkistrodon halys have been poisonous snake, and wind-damp dispelling, the meridian dredging effect are comparatively strong, and Zaocys and the two same use, it knowingly follows the example of a wrongdoer good.For rheumatic arthralgia or rheumatoid arthritis, poker back etc.Zaocys 1, soup is boiled in section.Add leaf fat, salt, a little seasoning of Rhizoma Zingiberis Recens, meat eaten by drink soup.Zaocys has expelling wind and removing dampness and Detoxication, also has certain prevention or therapeutic effect for urticaria, eczema abscess.We and make soup thick soup to boil, be especially suitable for edible.
Radix Aconiti Preparata is pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.How to use after the process of preparing Chinese medicine.
Oleum Sesami is the fatty oil squeezed from Hu section plant sesame seed, and general Semen Sesami Nigrum takes, and Semen sesami Albae extracts oil.Meridian distribution of property and flavor: sweet, cool, nontoxic.Chemical composition: in Oleum Sesami, main component is unsaturated fatty acid, accounts for 85%-90%, oleic acid and linoleic acid respectively account for 50% substantially, are characterized in that stability is strong, and easily preserve, this is because containing a kind of Natural antioxidant---Semen Sesami acid in Oleum Sesami.Also containing mineral such as protein, sesamin, vitamin E, lecithin, sucrose, calcium, phosphorus, ferrum in Oleum Sesami, it is a kind of edible oil of vegetal pole horn of plenty.Effect: Chinese medicine is thought: this product nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.Record according in Compendium of Material Medica: " have moisturize, detoxify, pain relieving, detumescence merit." " not Lu " say: " sharp large intestine, afterbirth does not fall.Survivor's lump of rubbing swells, raw alopecia." clinically also decoct plaster with Oleum Sesami, there is granulation promoting meat, an effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.Containing sesamin in linum, when with siritch parch or bake dish or food, the compound of sesamin and the acid of decomposable asymmetric choice net (+) Semen Sesami and some fragrance, these fragrance matters can volatilize at normal temperatures, its aromatic flavor, elegant, tempting appetite are that other similar vegetable oil all hardly match.
The preparation method of capsule of the present invention:
First by Radix Astragali 1500g, Poria 1500g, Radix Polygoni Multiflori Preparata 1500g, Radix Gentianae Macrophyllae 1500g, Radix Rehmanniae Preparata 1500g, Radix Dipsaci 1500g, Radix Codonopsis 1500g, Radix Achyranthis Bidentatae 1500g, Ramulus Cinnamomi 1500g, Radix Angelicae Pubescentis 1500g, Herba Taxilli 1500g, Cortex Cinnamomi 1500g, Rhizoma Polygoni Cuspidati 1500g, Cortex Eucommiae 1500g, Rhizoma Cibotii 1500g, Lycopodium casuarinoides Spring 1500g, Rhizoma Drynariae 1500g, Radix Salviae Miltiorrhizae 1500g, geranium 1500g, Radix Paeoniae Rubra 1500g, Rhizoma Corydalis 1500g, Eupolyphaga Seu Steleophaga 1500g, Fructus Psoraleae 1500g, first all crude drug are cut into coarse granule, then ethanol is put into, soak more than 2 hours, add 8 times amount accounting for crude drug gross mass respectively, the ethanol heating extraction of 6 times amount 2 times, extraction time is 2 hours, 1 hour, merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum, as component 1, and stand for standby use.Again the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.Above-mentioned two kinds of component extractum are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m2, hothouse hot stream temperature is 80 DEG C, obtains crude drug medicated powder; Incapsulate after ultraviolet sterilization.
The preparation method of the present invention's honey refining pill:
First by Rhizoma Atractylodis 1200g, Poria 1100g, Radix Polygoni Multiflori Preparata 1200g, Radix Gentianae Macrophyllae 1100g, Radix Rehmanniae Preparata 1200g, Radix Dipsaci 1200g, Flos Carthami 1100g, Radix Achyranthis Bidentatae 1200g, Ramulus Cinnamomi 1200g, Radix Angelicae Pubescentis 1100g, Herba Taxilli 1200g, Cortex Cinnamomi 1100g, Rhizoma Polygoni Cuspidati 1100g, Semen Sinapis Albae 1100g, Radix Saposhnikoviae 1100g, Lycopodium casuarinoides Spring 1200g, Rhizoma Drynariae 1200g, Radix Salviae Miltiorrhizae 1200g, geranium 1200g, Radix Paeoniae Alba 1200g, Radix Notoginseng 1200g, Eupolyphaga Seu Steleophaga 1200g, Rhizoma Osmundae 1200g, soaks 30 minutes to 1 hour, and heating boils 30 ~ 40 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 20 ~ 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, pulverizing and Mel are in harmonious proportion and are twisted into pill.
The preparation of Tablets:
First by Radix Astragali 1200g, Poria 1300g, Radix Polygoni Multiflori Preparata 1200g, Radix Gentianae Macrophyllae 1200g, Radix Rehmanniae Preparata 1100g, Radix Dipsaci 1200g, Radix Codonopsis 1100g, Radix Achyranthis Bidentatae 1200g, Ramulus Cinnamomi 1100g, Radix Angelicae Pubescentis 1200g, Herba Taxilli 1200g, Cortex Cinnamomi 1100g, Rhizoma Polygoni Cuspidati 1200g, Cortex Eucommiae 1200g, Rhizoma Cibotii 1200g, Lycopodium casuarinoides Spring 1100g, Rhizoma Drynariae 1200g, Radix Salviae Miltiorrhizae 1100g, geranium 1200g, Radix Paeoniae Rubra 1200g, Rhizoma Corydalis 1200g, Eupolyphaga Seu Steleophaga 1100g, Fructus Psoraleae 1200g, first all crude drug are cut into coarse granule, then ethanol is put into, soak more than 2 hours, add 8 times amount accounting for crude drug gross mass respectively, the ethanol heating extraction of 6 times amount 2 times, extraction time is 2 hours, 1 hour, merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum, as component 1, and stand for standby use.Again the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.Above-mentioned two kinds of component extractum are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m2, hothouse hot stream temperature is 80 DEG C, obtains crude drug medicated powder, adds starch tabletting.
The preparation of medicinal external emulsifiable paste agent of the present invention:
First Fructus Foeniculi 1500g, Sanguis Draxonis 1500g, Myrrha 1500g, Rhizoma Et Radix Notopterygii 1500g and the Rhizoma Homalomenae 1500g way of distillation are vaporized into crystallization, pulverize for subsequent use; By all the other crude drug medicine Radix Dipsacis 1500g, Flos Carthami 1500g, Rhizoma Homalomenae 1500g, Radix Tripterygii Wilfordii 1500g, Radix Aconiti Preparata 1500g, Scorpio 1500g, Herba speranskiae tuberculatae 1500g, Rhizoma Polygoni Cuspidati 1500g, Semen Strychni 1500g, Zaocys 1500g, add and account for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 5 ~ 8 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use; In described steps d, above-mentioned 2 kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, adds the crystalline powder prepared, and the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste.
The preparation of emplastrum of the present invention: first Fructus Foeniculi 1200g, Sanguis Draxonis 1100g, Myrrha 1200g, Rhizoma Et Radix Notopterygii 1200g and the Rhizoma Homalomenae 1200g way of distillation are vaporized into crystallization, pulverize for subsequent use; By all the other crude drug medicine Radix Dipsacis 1500g, Flos Carthami 1100g, Rhizoma Homalomenae 1200g, Radix Tripterygii Wilfordii 1200g, Radix Aconiti Preparata 1200g, Scorpio 1200g, Herba speranskiae tuberculatae 1200g, Rhizoma Polygoni Cuspidati 1200g, Semen Strychni 1200g, Zaocys 1100g, put into ethanol heating and refluxing extraction 2 times; Each 1 ~ 2 hour, extracting solution is left standstill.The crude drug medical material crossed by ethanol extraction adds water heating and refluxing extraction 1 time, each 1 ~ 2 hour; Then 2 kinds of extracting solution are merged and leave standstill.Merged by above-mentioned two kinds of extracting solution, will merge in the extracting solution suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Three filtrates be combined, heating is concentrated into pasty state, the distillation crystalline powder of mediation preparation, is in harmonious proportion and spreads on the joint that swells and ache, paste medicine part, need clean, fix with preservative film, medical adhesive tape with wine, vinegar, Mel.Can tolerate as degree with patient, take off after general 5h, every day 1 time.
The preparation of plaster of the present invention:
First first Fructus Foeniculi 1200g, Sanguis Draxonis 1100g, Myrrha 1200g, Rhizoma Et Radix Notopterygii 1200g and the Rhizoma Homalomenae 1200g way of distillation are vaporized into crystallization, pulverize for subsequent use; By all the other crude drug medicine Radix Dipsacis 1500g, Flos Carthami 1100g, Rhizoma Homalomenae 1200g, Radix Tripterygii Wilfordii 1200g, Radix Aconiti Preparata 1200g, Scorpio 1200g, Herba speranskiae tuberculatae 1200g, Rhizoma Polygoni Cuspidati 1200g, Semen Strychni 1200g, Zaocys 1100g, the crude drug medical material of above-mentioned parts by weight adds in the Oleum Sesami accounting for its 5-10 times weight portion and soaks 3-5 days, heating extraction, first big fire is boiled, Oleum Sesami boiling after firepower reduce, endure to pharmaceutical presentations be dark brown, inner coke yellow, pull medicinal residues out, continued to temper by medicine oil, and constantly stir, refining is to the beading that drips; Again Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity; Plumbum preparatium is slowly added in the medicine oil refined, constantly stir, become the thick paste of black, again the crystallization of pulverizing is stirred in the slightly cold rear impouring cold water of the plaster refined, soak 5-10 days, change water every day once, releasing fire-toxin.
Patient's wash clean patient part, pasted potion breast of the present invention and was affixed on affected part, take off after 24 hours every night.External posts agent of the present invention can 25 days be use a course for the treatment of, and not easily pollution clothes, easy to use, fast.
Toxicology test:
Test example 1: acute toxicity test of the present invention
One, test material:
Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: Tablets, containing 0.0365g crude drug/sheet
Two, method:
1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve tablet adding distil water, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Tablet adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity
(18g/Kg.d), have no dead mouse, namely do not measure LD50, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.
Experimental example 2: aggregate toxicity is tested:
The agent of Chinese medicine preparation of the present invention honey refining for oral administration pill presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation oral capsule of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Experimental example 3: acute dermal toxicity result of the test
Medicine externally used compound preparation of the present invention, has expelling wind and removing dampness, and effect of promoting blood circulation to remove obstruction in the collateral is used for the treatment of the disease such as rheumatism, rheumatoid arthritis.Accordingly, first carry out acute dermal toxicity test, to observe this medicine to the nontoxic level in the whether true border of rat acute percutaneous toxicity.
Tested material: the preparation ointment of external of the present invention.Weighing tested material 50g adding distil water, to make 50% pastel for subsequent use.
Laboratory animal: provide SD rat 20 by Medicine Institute, Shandong Province Experimental Animal Center, male and female half and half, body weight 180-220g, primary animal (dynamic No. 08-25th, the word of doctor), feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%, the Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test first 24 hours, in back part of animal spinal column both sides unhairing, unhairing scope is about body surface area 10%.By the dosage (coating amount 1.0g/100g.bw) of 5000mg/kg.bw, examination Mus unhairing position is applied and fixed, after 24 hours, the residual tested material of warm water removing, Continuous Observation 7 days.Result of the test: have no examination Mus whole body ANOMALOUS VARIATIONS in the observation period, also have no dead, is coated with the reactions such as tested material local has no red and swollen, festers, inflammation, necrosis.These results suggest that this medicine is to the nontoxic level in the true border of rat acute percutaneous toxicity.
Experimental example 4: repeatedly Skin Irritation Test result
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", repeatedly Skin Irritation Test is carried out to medicine of the present invention.
Tested material: liniment of the present invention.Weighing tested material 50g adding distil water, to make 50% pastel for subsequent use.
Laboratory animal: provide Japanese white big ear rabbit 4 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 2.5-3.0kg, primary animal (dynamic No. 08-018th, the word of doctor), feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Only get tested material 0.5g/, be coated in after preparation on the skin of every rabbit side, smear every day once, offside all makes solvent control.Smear 14d continuously.Cropping before being coated with every day, must not injured skin, ensures that tested material fully contacts with skin.Observe dermoreaction and marking every day.Off-test, gets and smears area skin and carry out histopathologic examination.
Experimental result: repeatedly Skin Irritation Test shows that repeatedly the highest stimulation index of skin irritation and pathological tissue integration are 0 in the present invention, according to skin irritation strength grading standard in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the present invention repeatedly skin irritation intensity belongs to nonirritant.
Experimental example 5, skin anaphylactic test
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", skin anaphylactic test is carried out to medicine of the present invention.
Tested material: liniment of the present invention.Weighing tested material 10g adding distil water, to make 50% pastel for subsequent use.Positive control: 2,4-dinitro-chloro-benzene, produce in Xing Jin chemical plant, Beijing, lot number 20020522.Laboratory animal: provide Cavia porcellus 30 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 250-300g, primary animal, feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test Cavia porcellus is divided into three groups at random, often organize 10, male and female half and half, are respectively tested material group, negative control group and positive controls.
Sensitization contact: removed by guinea pig back left of spine hair for first 24 hours to tested material, unhairing scope is about 3cm × 3cm.Get tested material 0.2g/ only, be coated in district of losing hair or feathers on the left of back part of animal after preparation, continue 6 hours.7th day and fortnight, repeat once with same method, and positive controls is coated with 1%DNCB, and negative control group does not deal with.Excite contact: fortnight after last is to tested material, by tested material 0.2g/ only, be coated on district of losing hair or feathers on the right side of guinea pig back after preparation, remove tested material after 6 hours, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hour.Positive controls is coated with 1%DNCB, and negative control group does not deal with.Observational technique is with tested material group.
Result of the test: skin anaphylactic test shows patch of the present invention, according to according to sensitization of skin intensity evaluation standard relevant in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the invention belongs to without sensitization.
Experimental example 6, anti-inflammation test, analgesic test, microcirculation test
Anti-inflammation test: tested group of mouse ear inflammation swelling is less than blank group, and difference has significance (P<0.05), illustrates that patch of the present invention has certain antiinflammatory action.Analgesic test: tested group of mouse writhing number of times reduces than blank group, and difference has significance (P<0.05).Illustrate that patch of the present invention has certain analgesic activity.
Microcirculation test: tested group of Mice Auricle fine motion, vein bore and capillary vessel number all comparatively blank group obviously increase, and difference all has highly significant (P<0.01), illustrate that patch of the present invention has and improve the microcirculatory effect of Mice Auricle.
Pharmacological experiment illustrates:
Pharmacological experiment
The compound preparation that oral medicine of the present invention is made up of Chinese crude drugs such as Rhizoma Cibotii, Radix Polygoni Multiflori Preparata, the Cortex Eucommiae, Herba Taxilli, Rhizoma Corydalis, Flos Carthami, Radix Achyranthis Bidentataes, has the effect of liver and kidney tonifying, activating blood circulation to dissipate blood stasis, removing obstruction in the collateral to relieve pain.The lumbago and skelalgia that to cure mainly that caused by liver and kidney deficiency, QI-blood circulation are smooth, blood stasis is stagnated, venation is obstructed etc. caused, and the effect of lumbar muscle strain, and with YAOTONGNING (take), unblocking collaterals to treat arthritis subsides (external) compares
1, instrument and material
GSH-II type operating loupe (Tianjin medical optical instrument factory), the full-automatic blood flow of FASCO-3010A accelerates and surveys instrument (Weiduo Bioengineering Institute of Chongqing University).YAOTONGNING (Chengde Chinese medicine Group Co., Ltd, lot number: 040119).W istar rat, white big ear rabbit, male and female dual-purpose, is purchased from Chinese Medical Sciences University's Experimental Animal Center, production licence number: SCXK2003-0009.Unblocking collaterals to treat arthritis pastes, and is to be produced by Jilin Wan Tong Pharmaceutical group, Ji Weijian No. 024th, word (2006).Alleviate the pain that femur head necrosis, hyperosteogeny, cervical spondylosis, lumbar spondylosis, intervertebral disk hernia, rheumatic arthritis, ankylosing spondylitis, scapulohumeral periarthritis, traumatic injury, Senile osteoarthritis etc. cause, promote its rehabilitation.Suitable population: be applicable to because of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, lumbar muscle strain, hyperosteogeny, traumatic injury, the pain that prolapse of lumbar intervertebral disc etc. cause and lumbago and skelalgia, sciatica
2, method
2,1 the present invention is to the effect of rabbit lumbar muscle strain
Get the sodium sulfide depilation that healthy white big ear rabbit mass fraction is 10%, after pentobarbital sodium 30mg/kg-1 anaesthetizes, under sterile working, centered by crista iliaca to ischial tuberosity line mid point spinous process side 0,5cm place, cut skin, subcutaneous tissue along spinous process direction, the sacral nerves of walking out intervertebral foramina can be seen in the dark face of open center, be then 2 by quality, 5mg, diameter is that the circular filter paper sheet of 5mm is put in nerve root armpit, successively.Sew up, sterile dressing.Rabbit 80 of being paralysed by Post operation is divided into 5 groups at random, and often organize 16, postoperative 3d starts administration, is respectively excipient control group, skin paste excipient; The high, medium and low dosage group of the present invention, skin adhesive plaster, takes off after sticking 6h every day; Positive control drug YAOTONGNING group, SHEXIANG ZHUANGGU GAO group, gastric infusion; Administration every day 1 time, successive administration 30d.Each treated animal respectively at postoperative 1st, 7,14,21,28d observed and recorded rabbit model activity sign: gait, the threshold of pain, sense of touch situation; Each group respectively after surgery the 5th, 15,25d randomly draws 2 mould rabbits and puts to death, and causes while scorching stimulus object weighs, and gets its sacral nerve roots and surrounding tissue does pathological examination.After administration 30d, the blood sampling of each group Rabbit Heart measures hemorheology index.Put to death simultaneously, open operative site and fiber enclosed mass, measure filter paper quality, and get its sacral nerve roots and surrounding tissue does histopathologic examination, separately get normal rabbits 10, get its sacral nerve roots and surrounding tissue does histopathologic examination simultaneously.Gait: the degree that the paralysis of mould rabbit suffering limb recovers, criterion is as follows, panplegia: complete paralysis, and muscle ungauged regions, joint position does not change.Semi-paralysis: limbs can piecemeal activity, walking is walked lamely.Recover: very nearly the same with normal walking movement, tractive both sides lower-limb muscular strength is close.
The threshold of pain: with acupuncture mould rabbit toes to judge pain sensation recovery extent, criterion is as follows, responsive: acupuncture mould rabbit toes, and lower limb twitch retraction, later visits.Insensitive: acupuncture mould rabbit toes are reactionless, even stick a needle into skin also reactionless.Sense of touch: touch rabbit toes with dry cotton-wool, the difference of contrast Ipsilateral hind leg tactile sensing.Responsive: touch rabbit toes and respond, suffering limb is twitched.Insensitive: touch rabbit toes reactionless, suffering limb is without twitch.
2,2 the present invention are to the anti-inflammatory analgetic effect of In Rat Lumbar muscular strain model
Get the sodium sulfide depilation that healthy W istar rat mass fraction is 10%, after urethane 1,2g/kg-1 anesthesia, under sterile working, centered by L4-5 interspinal interstice, be about 4cm at back median incision, cut skin, subcutaneous tissue.Blunt separation waist paravertebral muscles, self-retractor retracts, and stings except L4-5 spinous process, right side vertebral plate and articular process, fully cauda equina nerve and right side L5 nerve root is exposed under operating loupe, the silica gel piece of about 25mg is placed in the armpit that right side L5 nerve root goes out dural sac, wrapping is fixing, layer-by-layer suture.Operation modeling success rat 50 is divided into 5 groups at random, often group 10, model control group, the present invention is for oral administration, the high, medium and low dosage group of externally used paste, and positive control drug YAOTONGNING group, unblocking collaterals to treat arthritis subsides group, separately get 10 rats and make blank group.The postoperative 3d of each treated animal starts administration, administration every day 1 time, successive administration 30d.After last administration terminates, get local organization around nerve root, prepare tissue homogenate, centrifuging and taking supernatant, measure PGE2 and Assay of histamine levels.
2,3 statistical procedures
Enumeration data X 2 test, measurement data data represent with (-x ±-s), and between group, group difference is compared in t inspection.
3, experimental result
3,1 apophysis spirit cream recovers the comparison of number of cases and positive rate to panplegia mould rabbit
Gait: postoperative 1st day of modeling, each treated animal is all in panplegia state.From the 1st day to the 7th day, the ratio of semi-paralysis is returned to by panplegia, of the present invention group and YAOTONGNING group compare there was no significant difference (P>0,05) with matched group, from the 7th day to the 28th day, by semi-paralysis to each administration group of ratio recovered and matched group comparing difference significantly (P<0,05, P<0,01), in table 1.
The threshold of pain: postoperative 1st day, the reaction of the mould rabbit pain sensation is feminine gender, and from the 7th day to the 28th day, cream group was taken in the present invention orally and the YAOTONGNING group threshold of pain is obviously better than matched group (P<0,05, P<0,01), in table 2.
Table 2 mould rabbit analgesic activity result of the test (± S, n=10)
Note: compare * P<0.05 with Matrix controls group, * * P<0.01
Sense of touch: postoperative 1st day, mould rabbit tactile response was feminine gender, from the 7th day to the 28th day, external plaster group of the present invention and the sense of touch of unblocking collaterals to treat arthritis subsides group obviously than matched group sensitivity (P<0,05), in table 3.
Table 3 mould rabbit tactile response result of the test (± S, n=10)
Note: compare * P<0.05 with Matrix controls group, * * P<0.01
Perusal nasal mucosa change after mice is put to death in cervical vertebra fracture, comprises nasal mucosa color and luster, with or without hyperemia, edema, hemorrhage, ulcer etc. and each organ of mice is with or without obvious change.Each administration group be significantly increased panplegia rabbit 14,21,28d time recover positive rate, with matched group comparing difference significantly (P<0,05, P<0,01).Show that the recovery of externally used paste of the present invention to the motion of mould rabbit suffering limb, the pain sensation, sense of touch has obvious facilitation.
Specific embodiment: Zhao, man, 42 years old, first visit on February 8 in 2013, lifted weight before about two years and sprains waist, led and thigh discomfort, transference cure after simple treatment of having a rest, leave over chronic problem, time light time heavy, heavy then feel that thigh sinks to right lower extremity acid, instep and hallux toe place picotement, about increased the weight of suddenly before January, waist buttocks and legs pain is abnormal, walks unfavorable.Through traction and transfusion oral drugs without alleviation.City Hospitals thinks outstanding comparatively large, and obviously, excision of advocating, examines because fearing operation in compressing.Straight-leg raising test is positive, and waist 4,5 hole place tenderness are not obvious, considers that intraspinal tube factor is large.Diet can, large dry stool, lower limb has cool feeling, the white greasy deep-rolling pulse of the slightly fat tongue of dimly red tongue.Readme lumbago, weakness of the lower extremities, clear urine in large amounts, poor memory, be afraid of cold, pulse-phase is heavy carefully unable, tongue fur is white, pale tongue; Examine as deficiency of both the liver and kidney, cold-phlegm stagnates, the obstructed kidney yang deficiency syndrome lumbar muscle strain of QI and blood.Oral medicinal herb: Radix Astragali 12g, Poria 13g, Radix Polygoni Multiflori Preparata 13g, Radix Gentianae Macrophyllae 12g, Radix Rehmanniae Preparata 13g, Radix Dipsaci 12g, Radix Codonopsis 11g, Radix Achyranthis Bidentatae 13g, Ramulus Cinnamomi 12g, Radix Angelicae Pubescentis 13g, Herba Taxilli 13g, Cortex Cinnamomi 13g, Rhizoma Polygoni Cuspidati 12g, Cortex Eucommiae 12g, Rhizoma Cibotii 11g, Lycopodium casuarinoides Spring 13g, Rhizoma Drynariae 12g, Radix Salviae Miltiorrhizae 13g, geranium 13g, Radix Paeoniae Rubra 13g, Rhizoma Corydalis 12g, Eupolyphaga Seu Steleophaga 13g, Fructus Psoraleae 12g; External used medicine: Myrrha 13g, Sanguis Draxonis 13g, Radix Dipsaci 12g, Rhizoma Et Radix Notopterygii 12g, Flos Carthami 12g, Rhizoma Homalomenae 14g, Radix Tripterygii Wilfordii 13g, Fructus Foeniculi 12g, Radix Aconiti Preparata 13g, Scorpio 14g, Herba speranskiae tuberculatae 12g, Rhizoma Polygoni Cuspidati 14g, Semen Strychni 13g, Zaocys 13g.After 5 doses, pain subtracts greatly, and after following the service January, pain disappears, and occasionally has toe instep numb, after follow up a case by regular visits to July, numbness without, weakness of the lower extremities improves, the ice-cold improvement of trick.Not fatigue is advised to suffer from cold, waist functional exercise.Follow up a case by regular visits to and do not recur for 1 year.

Claims (10)

1. treat the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain for one kind, it is characterized in that, be made up of endo-medicine and external used medicine, described endo-medicine comprises the crude drug of following parts by weight: the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Radix Dipsaci 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Cortex Eucommiae 10 ~ 20 parts, Rhizoma Cibotii 10 ~ 20 parts, Lycopodium casuarinoides Spring 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts,
External used medicine comprises the crude drug of following parts by weight: Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Zaocys 10 ~ 20 parts.
2. treat the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain according to claim 1, it is characterized in that, described endo-medicine comprises the crude drug of following parts by weight: the Radix Astragali 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Radix Gentianae Macrophyllae 10 ~ 15 parts, 10 ~ 15 parts, Radix Rehmanniae Preparata, Radix Dipsaci 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Cortex Eucommiae 10 ~ 20 parts, Rhizoma Cibotii 10 ~ 20 parts, Lycopodium casuarinoides Spring 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Fructus Psoraleae 10 ~ 20 parts,
External used medicine comprises the crude drug of following parts by weight: Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 15 parts, Radix Tripterygii Wilfordii 10 ~ 15 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Zaocys 10 ~ 20 parts.
3. treat the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain according to claim 1, it is characterized in that, described endo-medicine comprises the crude drug of following parts by weight: the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Gentianae Macrophyllae 10 ~ 20 parts, 10 ~ 20 parts, Radix Rehmanniae Preparata, Radix Dipsaci 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, the Cortex Eucommiae 10 ~ 15 parts, Rhizoma Cibotii 10 ~ 15 parts, Lycopodium casuarinoides Spring 10 ~ 15 parts, Rhizoma Drynariae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, geranium 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Fructus Psoraleae 10 ~ 15 parts,
External used medicine comprises the crude drug of following parts by weight: Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 15 parts, Radix Aconiti Preparata 10 ~ 15 parts, Scorpio 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, Zaocys 10 ~ 15 parts.
4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain, it is characterized in that, the dosage form of described endo-medicine is pill, and its preparation method comprises:
A. all crude drug are put into ethanol heating and refluxing extraction 2 times, as component 1;
B. get the medicinal residues after above-mentioned ethanol extraction again, the heating and refluxing extraction that adds water 2 times, as component 2;
C. said components merged, spraying dry after decompression recycling ethanol, obtains medicated powder; Mix Mel and be twisted into pill.
5. treat the preparation method of the oral medicinal herb pill of kidney yang deficiency syndrome lumbar muscle strain according to claim 4, it is characterized in that, in described step a, first all crude drug are cut into coarse granule, then ethanol is put into, soak more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount ethanol heating extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, one-tenth extractum, as component 1, and stand for standby use.
6. treat the preparation method of the oral medicinal herb pill of kidney yang deficiency syndrome lumbar muscle strain according to claim 4, it is characterized in that, in described step b, the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, becomes extractum standing, for subsequent use as component 2.
7. treat the preparation method of the oral medicinal herb pill of kidney yang deficiency syndrome lumbar muscle strain according to claim 4, it is characterized in that, in described step c, above-mentioned two kinds of component extractum are merged, to merge in the extraction extractum suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Spraying dry, obtains medicated powder, adds Mel and is twisted into pill.
8. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain, it is characterized in that, the dosage form of described external used medicine is plaster, and its preparation method comprises:
The crude drug of above-mentioned parts by weight is added in the Oleum Sesami accounting for its 5-10 times weight portion and soaks 3-5 days, heating extraction, first big fire is boiled, Oleum Sesami boiling after firepower reduce, endure to pharmaceutical presentations be dark brown, inner coke yellow, pull medicinal residues out, continued to temper by medicine oil, and constantly stir, refining is to the beading that drips; Again Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity; Plumbum preparatium is slowly added in the medicine oil refined, constantly stir, become the thick paste of black, in the slightly cold rear impouring cold water of the plaster refined, soak 5-10 days, change water every day once, releasing fire-toxin.
9. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine composition of kidney yang deficiency syndrome lumbar muscle strain, it is characterized in that, the dosage form of described external used medicine is ointment, and preparation method comprises:
A. Fructus Foeniculi, Sanguis Draxonis, Myrrha, Rhizoma Et Radix Notopterygii and the Rhizoma Homalomenae way of distillation are vaporized into crystallization, pulverize for subsequent use;
B. all the other crude drug medicines are added alcohol heating reflux and extract 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the alcohol heating and refluxing extraction that adds water 2 times;
D. merged by above-mentioned 2 kinds of extracting solution, add the crystallization prepared after decompression recycling ethanol concentrates, the glycerol that is in harmonious proportion stirs, fill after sterilization.
10. treat the preparation method of the ointment of kidney yang deficiency syndrome lumbar muscle strain according to claim 9, it is characterized in that, in described step a, first Fructus Foeniculi, Sanguis Draxonis, Myrrha, Rhizoma Et Radix Notopterygii and the Rhizoma Homalomenae way of distillation are vaporized into crystalline particle, are then ground into fine powder for subsequent use; In described step b, all the other crude drug are added and accounts for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times; Extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use; In described steps d, above-mentioned 2 kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, adds the crystalline powder prepared, and the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste.
CN201410699302.2A 2014-11-27 2014-11-27 Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition Pending CN104474114A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410699302.2A CN104474114A (en) 2014-11-27 2014-11-27 Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410699302.2A CN104474114A (en) 2014-11-27 2014-11-27 Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition

Publications (1)

Publication Number Publication Date
CN104474114A true CN104474114A (en) 2015-04-01

Family

ID=52748815

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410699302.2A Pending CN104474114A (en) 2014-11-27 2014-11-27 Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition

Country Status (1)

Country Link
CN (1) CN104474114A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105194455A (en) * 2015-09-18 2015-12-30 马鞍山德宏堂生物科技有限公司 External liniment for treating lumbar muscle degeneration
CN106421525A (en) * 2016-11-11 2017-02-22 东莞市百替生物科技有限公司 Traditional Chinese medicine composition for treating lumbar muscle strain and its preparation method
CN107375887A (en) * 2017-08-15 2017-11-24 山东仲景健康服务有限公司 One kind is for yang-deficiency constitution massage Chinese medicine oil breast

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129595A (en) * 2007-08-29 2008-02-27 尹克山 Traditional Chinese medicine for treating deficiency of the kidney and lumbago
CN101274067A (en) * 2007-03-26 2008-10-01 郭茂武 Medical ointment for activating blood circulation, removing stasis, dredging channels and collaterals, releasing swelling and relieving pain, and method for preparing the same
CN101485836A (en) * 2008-01-16 2009-07-22 孙玉湘 Oral capsule for treating neck, waist and leg pain diseases and preparation method thereof
CN101554430A (en) * 2009-05-08 2009-10-14 李植云 Medicinal liquor for treating rheumatic sciatica
CN102973714A (en) * 2012-12-16 2013-03-20 青岛华电高压电气有限公司 Traditional Chinese medicine composition for treating lumbar muscle strain and preparation method thereof
CN104107338A (en) * 2013-04-17 2014-10-22 商月波 Medicated wine for treating rheumatism

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101274067A (en) * 2007-03-26 2008-10-01 郭茂武 Medical ointment for activating blood circulation, removing stasis, dredging channels and collaterals, releasing swelling and relieving pain, and method for preparing the same
CN101129595A (en) * 2007-08-29 2008-02-27 尹克山 Traditional Chinese medicine for treating deficiency of the kidney and lumbago
CN101485836A (en) * 2008-01-16 2009-07-22 孙玉湘 Oral capsule for treating neck, waist and leg pain diseases and preparation method thereof
CN101554430A (en) * 2009-05-08 2009-10-14 李植云 Medicinal liquor for treating rheumatic sciatica
CN102973714A (en) * 2012-12-16 2013-03-20 青岛华电高压电气有限公司 Traditional Chinese medicine composition for treating lumbar muscle strain and preparation method thereof
CN104107338A (en) * 2013-04-17 2014-10-22 商月波 Medicated wine for treating rheumatism

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105194455A (en) * 2015-09-18 2015-12-30 马鞍山德宏堂生物科技有限公司 External liniment for treating lumbar muscle degeneration
CN106421525A (en) * 2016-11-11 2017-02-22 东莞市百替生物科技有限公司 Traditional Chinese medicine composition for treating lumbar muscle strain and its preparation method
CN107375887A (en) * 2017-08-15 2017-11-24 山东仲景健康服务有限公司 One kind is for yang-deficiency constitution massage Chinese medicine oil breast

Similar Documents

Publication Publication Date Title
CN103520654B (en) A kind of Chinese medicine composition being used for the treatment of knee osteoarthritis and preparation method thereof
CN101810685B (en) Chinese medicinal composition for treating gonitis and preparation method thereof
CN101015651A (en) Medicine for treating protrusion of lumbar intervertebral disc
CN104666698A (en) External-use traditional Chinese medicine ointment for treating gonarthromeningitis and preparation method of traditional Chinese medicine ointment
CN104666579A (en) Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition
CN104306495B (en) A kind of Chinese medicine for external application of cure scapulohumeral periarthritis and preparation method thereof
CN102166278B (en) Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof
CN103961424A (en) Traditional Chinese medicine formula for treating cervical spondylosis and preparation method of traditional Chinese medicine capsule preparation
CN104689226A (en) Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof
CN102872286B (en) Traditional Chinese medicine composition for curing lumbar interveterbral disc protrusion and preparation method thereof
CN104435169A (en) Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of traditional Chinese medicine combination
CN103520655A (en) Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof
CN104474114A (en) Traditional Chinese medicine composition for treating kidney-yang deficiency type lumbar muscle strain and preparation method of traditional Chinese medicine composition
CN104324340A (en) Traditional Chinese medicine preparation for treating calcaneal bone hyperplasia and preparation method of traditional Chinese medicine preparation
CN104398962A (en) Chinese medicinal composition for treating spleen and kidney deficiency type lumbar muscle degeneration and preparation method thereof
CN102178781B (en) Chinese medicine composition for treating scrotum eczema and preparation method thereof
CN105943705A (en) Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof
CN105998246A (en) Externally-used traditional Chinese medicine paste for treating painful heel and preparation method thereof
CN104353051A (en) Traditional Chinese medicine preparation for treating stomachache and preparation method thereof
CN105920130A (en) Preparation method and externally used ointment of traditional Chinese medicine for treating talalgia
CN104958677A (en) Traditional Chinese medicine preparation for treating membranous nephropathy and preparation method of traditional Chinese medicine preparation
CN103751467A (en) Traditional Chinese medicine composition for treating lumbar and back myofascitis and preparation method thereof
CN104398888A (en) Chinese medicinal composition for treating kidney yin deficiency type lumbar muscle degeneration and preparation method thereof
CN104127737A (en) Pharmaceutical composition for preventing and treating postoperative complications of haemorrhoids and preparation method of pharmaceutical composition
CN105920189A (en) Traditional Chinese medicine composition for treating talalgia due to liver-kidney deficiency and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20150401

RJ01 Rejection of invention patent application after publication