CN104666698A

CN104666698A - External-use traditional Chinese medicine ointment for treating gonarthromeningitis and preparation method of traditional Chinese medicine ointment

Info

Publication number: CN104666698A
Application number: CN201410698881.9A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Current assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Priority date: 2014-11-26
Filing date: 2014-11-26
Publication date: 2015-06-03

Abstract

The invention provides an external-use traditional Chinese medicine ointment for treating gonarthromeningitis. The external-use traditional Chinese medicine ointment comprises the following raw materials in parts by weight: 10-20 parts of gentiana macrophylla, 10-20 parts of radix angelicae, 10-20 parts of radix angelicae pubescentis, 10-20 parts of cinnamon, 10-20 parts of cortex Illicii, 10-20 parts of radix clematidis, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of common clubmoss herb, 10-20 parts of rhizoma drynariae, 10-20 parts of salviae miltiorrhizae, 10-20 parts of erodium stephanianum willd, 10-20 parts of ground beeltle, 10-20 parts of earthworm, 10-20 parts of dragon's blood, 10-20 parts of olibanum, 10-20 parts of dipsacus asperoids, 10-20 parts of notopterygium, 10-20 parts of flos carthami, 10-20 parts of homalomena occulta, 10-20 parts of tripterygium glycosides, 10-20 parts of radix aconiti preparata, 10-20 parts of scorpio, 10-20 parts of garden balsam stem, 10-20 parts of polygonum cuspidatum, 10-20 parts of nux vomica, 10-20 parts of picrasma quassioides, 10-20 parts of zaocys dhumnade and 10-20 parts of cortex lycii radicis. The ointment is externally applied to stimulate intramuscular nerve endings, so that dynamic balance of generation and absorption of the intramuscular nerve endings restores by reflecting and expanding blood vessels, promoting local blood circulation, improving surrounding tissue nutrition and prompting liquid absorption in bursa mucosa to reach the target of removing synovial inflammation in the bursa mucosa to heal. The traditional Chinese medicine ointment is capable of activating blood circulation to remove stasis, expelling wind, dispelling cold, removing swelling, relieving pain and strengthening tendons and bones.

Description

A kind of Chinese medicinal external-application ointment for the treatment of gonarthromeningitis and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind of Chinese medicinal external-application ointment for the treatment of gonarthromeningitis and preparation method thereof.

Background technology

Knee synovitis, is secondary to knee joint osteoarthritis old people more, mainly because of the mechanicalness biochemistry sexual stimulus that cartilage degeneration and hyperosteogeny produce, secondary knee joint synovial membrane edema, to ooze out and hydrops etc.Caused by the acute creation of between twenty and fifty people Duo Yin and chronic injury.Acute trauma includes: sprain of knee joint, meniscus injury, side para-ligament or cruciate ligament, and intraarticular hydrops or sometimes hematocele show as acute knee traumatic synovitis.Sometimes also can because of caused by the damage of simple knee joint synovial membrane, as wound is comparatively light, or the strain of long-term chronic knee joint.Add the invasion and attack of wind, cold, wet heresy, knee joint can be made to engender swelling and dysfunction person, then form chronic knee synovitis.

Knee synovitis easily causes patient temporarily or long term portion disability, all larger to patient's harm.At present, though by many effective Therapeutic Method, many patients are still had still can not to cure.Especially part middle-young patients, bear many societies and home duties, the torment simultaneously born the pain for a long time again.

Arthroncus type mainly after hyperkinesia swelling be main, pain weight differs.Non-swelling-type, based on arthralgia, often with mild swelling.Research confirms, two type essence are identical, and just synovial membrane pathological change degree is different and different.Researcher finds, after the long-time single action excess motion of knee joint, synovial tissue's congestion and edema, red, leukocyte and cellulose ooze out intrinsic pressure rising and partial pressure of oxygen with articular cavity and decline to being proportionate and be, and when leaching rate exceedes synovial membrane compensatory infiltration rate, hydrarthrosis, and then the intrinsic pressure continuation of articular cavity is raised, partial pressure of oxygen continues the vicious cycle declined, the chronic aseptic inflammations such as synovial membrane regression fatization of a specified duration is raw are formed, thus think, after excess motion, the generation of traumatic synovitis, not only with the repeated impact of articular surface, the damage of joint capsule is relevant, and the course of disease development and lapse to important role.

After the damage of knee synovial membrane, synovial membrane presents hyperemia, edema and neutrophil infiltration.Synovial membrane vasodilation, blood plasma and cell exosmose, and produce a large amount of transudate, and synovial cell enlivens simultaneously, produces a large amount of mucoitin.Containing erythrocyte, leukocyte, the red matter of gallbladder, fat, mucoitin and cellulose etc. in transudate.Severe patient hydrarthrosis is in courageous and upright.Arthroncus and limitation of activity.As processed not in time, can there are synovial membrane plumpness, intra-articular adhesion and cartilage degeneration etc. in late period.If repeatedly damaged, synovial membrane reaction can transfer to chronic, shows as lymphocyte and plasmocyte infiltrating.These phenomenons are the reaction of non-specific synovial membrane.When major injury causes synovial membrane defect, its healing is very fast, and this is because synovial cell can regenerate and hypertrophy, and other tissue and cell can biochemistry be also synovial cell simultaneously.But serious Knee Arthritis, synovial villi edema, hypertrophy, to thicken, formed manyly to differ in size, different plica synovialis, the fibroplasia of subsynovial connective tissue group, and synovial tissue is biological aging etc., makes synovial tissue's renewable reservoir ability significantly reduce.

Chinese medicine thinks that synovitis belongs to " arthromyodynia " category, articular synovitis is divided into and injures chronic strain two aspect outward.After on the beds such as knee joint suffers fractures, dislocate, ligament rapture, cartilage injury, synovium of joint all can be made simultaneously impaired.Long-pending stasis of blood hydrops after wound, damp and hotly wins mutually, and make knee joint heating, distending pain, scorching hot, muscle contracture, obstacle is bent and stretched in joint, formation acute synovitis; As injured comparatively light, or long-term chronic strain, wind and cold, damp invasion and attack can make knee engender swelling, dysfunction in addition, form chronic synovitis.

The method for the treatment of synovitis, western medicine is thought more, does not also have ability that the pathology of synovitis is reversed at present, and patient can only use analgesic, pain killer injection, take out hydrops etc. carrys out relief of symptoms.But, usually emphasize that entirety treats, motherland's medical science for the treatment of must aim at the pathogenesis of disease early have research to this disease, and be longer than blood circulation promoting and blood stasis dispelling, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening traditional black plaster very good clinical therapeutic efficacy is achieved to it.

Synovial membrane mainly distributes periarticular.Communicate in articular cavity, secretion lubricating fluid lubricating joint.Stimulating by the various cause of disease (as hyperosteogeny, arthritis, tuberculosis of joint, rheumatism etc. and traumatic wound, bone injury, intraarticular damage, surrounding soft tissue's damage, operation etc.) or directly stimulating synovial membrane damage to produce inflammatory reaction, and the reaction of synovial membrane to the stimulation of inflammation is secretion sepage.Produce pain, strictly say, as long as intraarticular has ooze out hydrops, just prove that synovial membrane inflammation exists, its main manifestations arthremia swelling, pain, oozes out and increases, hydrarthrosis, and activity is squatted down difficulty, function limitation.

Synovitis is the aseptic inflammation because microcirculation does not freely cause; cardinal symptom produces hydrops, and synovium of joint surrounds periarticular skim tissue, and it is not only the tissue of one deck Saving cortilage; but also can joint fluid be produced, for the activity in joint provides " lubricating fluid ".The generation of joint fluid and absorption are one " dynamic equilibrium ", and when there is heavy malabsorption to joint fluid, because the generation of joint fluid and absorption dynamic equilibrium are broken, the generation of joint fluid is greater than and heavily absorbs, and just there will be " hydrarthrosis ".So treatment synovitis mainly nurses one's health microcirculqtory system, as long as microcirculation is unimpeded, hydrops also just circulates and disappears, same inflammation also just relieves, fatigue of trying not during hydrops, reduces the frequency of drawing liquid injection, too much injection of drawing water can stimulate the fibroplasia of subsynovial connective tissue group, and synovial tissue is aging etc., synovial tissue's renewable reservoir ability is significantly reduced, then treatment is just cumbersome.

Plaster external application is excited nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, makes it to return produce and absorb dynamic equilibrium, reaches and eliminates synovial membrane inflammation in synovial bursa and the object of fully recovering." Chu is sick in interior, must shape in outer ".When symptom appears in certain position of human body, will according to the trend of meridians during treatment, launch at knee and corresponding acupuncture point thereof simultaneously, and carry out cream cave combined treatment the corresponding course for the treatment of in accordance with this disease, to reach treating both the principal and secondary aspects of a disease, the thorough object cutting off recurrence root, external application stimulating acupoint, dredging microcirculation, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, make it to return and produce and absorb dynamic equilibrium, reach and eliminate synovial membrane inflammation in synovial bursa and the object of fully recovering.Internal and external medicine can also alleviate the side reaction that Western medicine brings, thus demonstrates its advantage place.

Summary of the invention

Technical problem to be solved by this invention is, the method for the treatment of synovitis, and western medicine is thought more, does not also have ability that the pathology of synovitis is reversed at present, and patient can only use analgesic, pain killer injection, take out hydrops etc. carrys out relief of symptoms; Drug therapy generally adopted chemical drugs and Chinese patent medicine in the past, and chemical drugs is soon effective, and these medicine toxicities are comparatively large, occur that lack of appetite is indigestion and loss of appetite, nausea and vomiting, stomach discomfort after a lot of patient medication.Plaster external application is excited nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, makes it to return produce and absorb dynamic equilibrium, reaches and eliminates synovial membrane inflammation in synovial bursa and the object of fully recovering.Blood circulation promoting and blood stasis dispelling of the present invention, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening, do not have the oral side reaction brought of Western medicine, thus demonstrate its advantage place.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicinal external-application ointment for the treatment of gonarthromeningitis, externally used paste described in it comprises the raw material of following parts by weight: Radix Gentianae Macrophyllae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Cortex Illicii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Ramulus Et Folium Picrasmae 10 ~ 20 parts, Zaocys 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts.

The Chinese medicinal external-application ointment of described treatment gonarthromeningitis, the crude drug of following parts by weight can be comprised: Radix Gentianae Macrophyllae 10 ~ 15 parts in externally used paste described in it, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Cortex Illicii 10 ~ 15 parts, Radix Clematidis 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, Herba Lycopodii 10 ~ 15 parts, Rhizoma Drynariae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, geranium 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Ramulus Et Folium Picrasmae 10 ~ 20 parts, Zaocys 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts.

The Chinese medicinal external-application ointment of described treatment gonarthromeningitis, the crude drug of following parts by weight can also be comprised: Radix Gentianae Macrophyllae 10 ~ 20 parts in externally used paste described in it, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Cortex Illicii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Olibanum 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 15 parts, Radix Tripterygii Wilfordii 10 ~ 15 parts, Radix Aconiti Preparata 10 ~ 15 parts, Scorpio 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, Ramulus Et Folium Picrasmae 10 ~ 15 parts, Zaocys 10 ~ 15 parts, Cortex Lycii 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicinal external-application ointment of gonarthromeningitis, and described in it, the preparation method of unguentum comprises:

A. the above-mentioned raw materials got except Cortex Cinnamomi, Olibanum, Rhizoma Et Radix Notopterygii, Sanguis Draxonis and Rhizoma Homalomenae is put into Oleum Sesami and is soaked;

B. more soaked crude drug is heated in Oleum Sesami and temper;

C. medicine oil is put in the Plumbum preparatium of having fried and stir into paste;

D. the ointment made is put into releasing fire-toxin in cold water;

E. Cortex Cinnamomi, Olibanum, Rhizoma Et Radix Notopterygii, Sanguis Draxonis and Rhizoma Homalomenae steaming process are distilled into crystalline particle, after pulverizing, add mix homogeneously in the ointment that makes.

In described step a, crude drug can be got and add in the Oleum Sesami accounting for its 5-10 times weight portion and soak 7-10 days.

In described step b, soaked for Oleum Sesami heating raw materials can be extracted, big fire is boiled, and after Oleum Sesami boiling, firepower reduces, and enduring to crude drug appearance is dark brown, and inner coke yellow, pulls medicinal residues out, is continued to temper by medicine oil, and constantly stirs, and refining is to dripping into pearl.

In described step c, Plumbum preparatium can be fried to dark yellow, removing moisture, cross 100 mesh sieve removing impurity; Added in the medicine oil refined, constantly stirred, become the thick paste of black.

In described steps d, by impouring cold water after the cooling of black thick paste, 5-10 days can be soaked, changes water every day once, releasing fire-toxin.

In described step e, Cortex Cinnamomi, Olibanum, Rhizoma Et Radix Notopterygii, Sanguis Draxonis and Rhizoma Homalomenae steaming process can be distilled into crystalline particle, pulverize 100 order dusting covers, then add in the ointment that makes and stir.

The Chinese medicinal external-application ointment of described treatment gonarthromeningitis, can by externally used paste heating of the present invention when it uses, and be in harmonious proportion spread on swelling and pain in knee joint with wine, vinegar, Mel, pasting medicine part need clean, and fixes with preservative film, medical adhesive tape.

Plaster external application of the present invention is excited nerve tip, by reflection, and blood vessel dilating, promote local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, make it to return and produce and absorb dynamic equilibrium, reach and eliminate synovial membrane inflammation in synovial bursa and the object of fully recovering.Blood circulation promoting and blood stasis dispelling of the present invention, expelling wind and cold, Repercusion analgesia, bone and muscle strengthening, do not have the oral side reaction brought of Western medicine, thus demonstrate its advantage place.The present invention is easy to use, and cheap, easy to use, can create good social value and economic interests.

Detailed description of the invention

Plaster external application is excited nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, makes it to return produce and absorb dynamic equilibrium, reaches and eliminates synovial membrane inflammation in synovial bursa and the object of fully recovering." Chu is sick in interior, must shape in outer ".When symptom appears in certain position of human body, will according to the trend of meridians during treatment, launch at " Ashi point " and corresponding acupuncture point thereof simultaneously, and carry out cream cave combined treatment the corresponding course for the treatment of in accordance with this disease, to reach treating both the principal and secondary aspects of a disease, the thorough object cutting off recurrence root, external application stimulating acupoint, dredging microcirculation, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, impel Liquid Absorption in synovial bursa, make it to return and produce and absorb dynamic equilibrium, reach and eliminate synovial membrane inflammation in synovial bursa and the object of fully recovering.Internal and external medicine can also alleviate the side reaction that Western medicine brings, thus demonstrates its advantage place.

Radix Gentianae Macrophyllae is Gentianaceae herbaceos perennial, is one of principal agent of the diseases such as dispelling the wind and dampness pathogens arthralgia, tuberculosis hectic fever, jaundice.Especially the best in quality with the Radix Gentianae Macrophyllae of Huang Nan product in Qinghai.Be one of important Chinese medicine of China, begin to be loaded in Shennong's Herbal, be classified as middle product, " the main cold and heat pathogen of Radix Gentianae Macrophyllae, cold-damp migratory arthralgia, arthrodynia of the extremities, Xia Shui, diuresis." for rheumatic arthralgia.Radix Gentianae Macrophyllae function wind-damp dispelling, relaxing muscles and tendons network, be usually used in the diseases such as rheumatic arthralgia, joint contracture, hands and feet caused by paralysis.This product property of medicine embellishes but not dry, no matter cold-damp, damp and hot, arthromyodynia is newly of a specified duration, all can apply.In compatibility, normal being equal to Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Ramulus Mori, is used.In addition, this product is the normal and same use of expelling pathogenic wind from the body surface medicine also, the disease for the treatment of exterior syndrome limb aching pain.

Radix Dipsaci, Chinese medicine name is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Geranium nature and flavor are pungent, bitter, flat.Gui Jing: return liver,kidney,spleen warp.Function cures mainly: wind-damp dispelling, the meridian dredging, antidiarrheal profit.For rheumatic arthralgia, numbness contracture, muscles and bones is ached, dysentery.Control bones and muscles pain, current meridians, remove all wind: fresh Herba Erodii is cleaned, and puts 100 jin in copper pot, decocts with water secondary, filter, then filtrate is concentrated into about 30 jin, add beverage wine five liang, boil ten minutes, finally add ripe Mel six jin, mixing is mixed thoroughly, boils 20 minutes, treats cold charge tank.(" Chinese medicine shape sex experience differential method " Herba Erodii cream).

Herba Lycopodii is used for anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle.External is controlled osteopatia sprain and is swollen and ache.Anemofrigid-damp arthralgia, limb softening wood.Pungent loose, bitter dry, Wen Tong, the energy Eradicates rheumatism of this product, enters the especially kind the meridian dredging of liver.Control anemofrigid-damp arthralgia, joint aches, joint stuffiness, can with the compatibilities such as Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Ramulus Cinnamomi, the Radix Paeoniae Alba; If limbs are weak, numbness of the skin, should be equal to Lignum Pini Nodi, Herba Aristolochiae Mollissimae, Radix Clematidis and use.

Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared." property of medicine opinion ": cure mainly: several pained, kills three worms, main removing blood stasis, and the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, and except cough with dyspnea, stagnation of QI, carbuncle numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison.

Radix Angelicae Pubescentis: expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache, " book on Chinese herbal medicine is just ": " specially reason part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness, pruritus due to damp pathogen contracture." modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation; And it is not have hypotensive effect, but lasting; Contained bergapten, xanthotoxin etc. have photosensitive and antitumor action.Anemofrigid-damp arthralgia.The pungent loose hardship of these product is dry, and the fragrant temperature of gas is logical, and merit is apt to Eradicates rheumatism, stopping numbness pain, is dispelling the wind and dampness pathogens arthralgia pain principal agent, the arthromyodynia that all wind-cold damp pathogens are caused, no matter for a long time new, all can apply; Enter kidney channel because it is main, property is apt to descending, is especially advisable with waist knee joint, lower limb joints of foot pain subordinate portion cold-damp person.Control the anemofrigid-damp arthralgia of the damp that is affected by the cold, muscle, back, brothers' pain, be often equal to use with Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae, as Radix Angelicae Pubescentis soup (" young new book of living "); If with compatibilities such as Herba Taxilli, the Cortex Eucommiae, Radix Ginsengs, arthromyodynia can be controlled with the passing of time weakened body resistance, soreness of the waist and knees, joint joint stuffiness person, as Radix Angelicae Pubescentis et Herba Taxilli Decoction (" prescriptions worth thousand gold ").

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.

Ramulus Et Folium Picrasmae, Simarubaceae Simaroubaceae Quassia formal name used at school: Picrasma quassioides (D.Don) Benn. nature and flavor are bitter, cold; Slightly poisonous.Return lung, large intestine channel.Function cures mainly heat clearing away, damp eliminating, removing toxic substances.For anemopyretic cold, laryngopharynx swelling and pain, diarrhoea dysentery, eczema, furuncle, venom.Heat-clearing and toxic substances removing; Removing dampness and killing parasites.Your Majesty's respiratory tract infection; Pneumonia; Acute gastroenteritis; Dysentery; Biliary tract infection; Furuncle; Scabies; Eczema; Burn due to hot liquid or fire; Venom.For anemopyretic cold, laryngopharynx swelling and pain, diarrhoea dysentery, eczema, furuncle, venom.For anemopyretic cold, laryngopharynx swelling and pain, diarrhoea dysentery, eczema, furuncle, venom.Effect: antibacterial quench, damp eliminating is detoxified.For flu, acute tonsillitis, enteritis, eczema; Venom.

Cortex Lycii heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil." herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." " not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat."

Eupolyphaga Seu Steleophaga has effect of removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Pharmacological evaluation, has the effect of dispersing swelling and dissipating binds.Cure mainly blood stasis etc. in traumatic injury, abdomen.Containing volatile oil and aminoacid.Volatile oil total amount about 22%, is mainly naphthalene, fatty aldehyde, aromatic aldehyde; Total amino acid content about 40%.Pharmacology: hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, erythrocyte aggregation index, erythrocyte mechanical fragility can be made all to reduce, make erythrocyte sedimentation rate, erythrocyte sedimentation rate constant obviously raises.In addition effects such as also having blood fat reducing, anoxia enduring, ease pain, resist myocardial ischemia.Cold in nature, salty in the mouth; Slightly poisonous.Function cures mainly: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.

Radix Angelicae Dahuricae acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose.There is expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidify sensible, effect of detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, venom.Expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping.For mastalgia, swell and ache, have a headache, have a toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Modern pharmacological research proves that the Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular.Radix Angelicae Dahuricae external is beauty treatment key medicine.The Compendium of Material Medica meaning Radix Angelicae Dahuricae " longue skin, moist color, can make face fat ", in ancient times beauty treatment sides multiplex it." herbal classic ": main woman's whitish metrorrhagia, blood closes swelling of the vulva, cold and heat, and public attention (wind syndrome of head) invades order lacrimation, longue skin, moist." not Lu ": treat ailment said due to cold or exposure thirsty (for a long time thirsty or doubt make ' chronic diarrhea ') for a long time, vomiting, fullness sensation in bilateral hypochondrium, wind pain dizziness, eye itching." property of medicine opinion ": control the twinge of trusted subordinate's blood, exorcising, main woman's metrorrhagia and vomiting, improving eyesight, arresting lacrimation go out, and treat married woman's drop blood, waist stomachache; Pus can be lost.

Cortex Illicii: this product is the dry bark of Magnoliaceae Fructus Anisi Stellati platymiscium Cortex Illicii Illicium difengpi K.I.B.et K.I.M..Spring, Qiu Erji strip, and dry or cold drying." Xinhua's book on Chinese herbal medicine outline ": bark: acrid in the mouth, puckery, warm in nature, slightly poisonous.There is evil-wind expelling and dampness removing, the function of promoting the circulation of QI to relieve pain.Chemical composition of Chinese materia medica: bark is containing volatile oil 0.3 one 0.71%, and in oil, composition is 28 kinds of compositions such as a mono-pinene, B mono-pinene, camphene, myrcene, cineole, linalool, Camphora, Radix Gentianae, ethyl acetate, safrole, cedrol.

Rhizoma Et Radix Notopterygii property is pungent, bitter in the mouth, temperature.Return bladder, kidney channel.Function cures mainly cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.For anemofrigid cold, headache body pain.The pungent temperature of this product, gas is male and fall apart, deliver power strong, the heresy of main loose Taiyang channel ailment said due to cold or exposure and cold-damp, have cold expelling to dispel the wind, the merit of removing dampness to relieve pain, therefore kindly control wind-cold damp pathogen and attack table, fever with aversion to cold, flesh table is lossless, headache stiffness of the nape, limb aching pain person, the same use of medicine such as normal and Semen Persicae, Rhizoma Et Radix Notopterygii, Radix Clematidis, Rhizoma Chuanxiong, as Notoptreygium Decoction of Nine Ingredients; If cold-damp lays particular stress on, headache body severe one, can the medicine such as compatibility Radix Angelicae Pubescentis, manuscript, Rhizoma Chuanxiong, as Decoction of Notopterygium for Rheumatism.Rhizoma Et Radix Notopterygii tanginess manufactures the good volatile oil of drop pill.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is amassed, or skin infection sufferings and swollenly burst uneasy, and be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted.

The analgesic therapy of Sanguis Draxonis dissipating blood stasis, hemostasia and promoting granulation.Control traumatic injury to lose, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.Tang Materia Medica: main the five internal organs pathogen, leukorrhagia, pain relieving, removing mass blood, gold creation meat." Haiyao Bencao, Oversea Materia Medica ": leadingly traumatic fracture damage, all pain, tonify deficiency and vim and vigour stir thorn, and interior blood trouble is gathered, and should wine clothes." Japan hanako materia medica ": control all malignant boil scabies and do not conform to person for a long time, applies.This property of medicine is anxious, also can not make more, but draw pus.

Olibanum regulating QI, invigorates blood circulation, and pain relieving chases after poison, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Supplement to the Herbal carries it: " treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine is let out, and treats all skin ulcers and makes internal diabetes.”

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.

Rhizoma Chuanxiong is pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

Scorpio is pungent, flat; Poisonous.Return Liver Channel.Function cures mainly endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Scorpion extraction liquid is in mouse tumor experiment, answer 0.2ml (suitable crude drug 0.04g/ only), every large subcutaneous administration after continuous 5 days, when medication the 11st day and drug withdrawal 8 days, be 38.8% and 55.5% to the suppression ratio of cell sarcoma (SRS) solid tumor; To MA 1 breast carcinoma, administration every day is after totally 12 times, and suppression ratio is 51.8%, is 30.4% during drug withdrawal 8 days.To the survival rate comparatively matched group prolongation 12.5%-20.7% of SRS ascitic type band tumor Mus.Result shows there is obvious inhibitory action to the tumor growth of mice with tumor.The Heal complete cell death of Scorpio extract In vitro culture takes off wall.29.2% is extended to LA 1 adenocarcinoma of lung mice with tumor life span.Buthus martensii karshi tail gavage, prevention administration group S180 sarcoma suppression ratio is 45%, and therapeutic administratp group S180 sarcoma suppression ratio is 47.6%, shows that it has preventive and therapeutic action concurrently.

Semen Strychni controls throat arthralgia pain, swollen ulcer drug, migratory arthralgia pain, fracture, facial paralysis, myasthenia gravis.1. removing obstruction in the collateral to relieve pain: by dispelling the wind and dampness pathogens insensitive impediment or contracture numbness.2, dispersing swelling and dissipating binds: with controlling wound pain caused by ecchymoma and ulcer sore pain.In recent years plant cancerous protuberance with Zhiduo County, have certain curative effect.3. treat poliomyelitis sequela, prolapse of lumbar intervertebral disc, trigeminal neuralgia, rheumatoid arthritis, traumatic injury, pain due to blood stasis, anemofrigid-damp arthralgia, general joint contracture, numbness, cancerous protuberance etc.

Radix Tripterygii Wilfordii, cry again Caulis Fibraureae, beeswax rattan, cabbageworm medicine, red medicine, water Folium illicii Lanceolati, Classification system: Tripterygiumwilfordii Hook.f. is the root of Celastraceae, tripterygium plant Radix Tripterygii Wilfordii, liana shrub, main product in Fujian, Zhejiang, Anhui, the ground such as Henan.In being born in the shade many wet hillside, mountain valley, small stream limit bushes.The hillside that happiness is comparatively shady and cool, the sand soil deep with slant acidity, soil layer or the most suitable growth of yellow soil.Bitter in the mouth, pungent, cool in nature, poison greatly.Return liver, kidney channel.Effect expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, reducing swelling and alleviating pain, removing toxic substances parasite killing.For damp and hot tuberosity, the long-pending poison of carcinoma, treat lepra reaction, rheumatoid arthritis etc. with it clinically, have the effect such as antitumor, antiinflammatory

Lycopodium casuarinoides Spring, rectification of name: rattan Lycopodium clavatum, has another name called: stone rattan, lycopodium casuarinoides etc., Latin literary fame: Lycopodiastrum casuarinoides (Spring) Holub ex Dixit.Expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Improving eyesight; Removing toxic substances.Cure mainly rheumatic arthralgia, lumbar muscle strain, traumatic injury, menoxenia, night sweat, conjunctivitis, nyctalopia, burn due to hot liquid or fire, sore swollen toxin." Traditional Chinese Medicine in Sichuan will " nineteen sixty version: " can relaxing muscles and tendons to promote blood circulation.Dispelling the wind and dampness pathogens arthralgia, traumatic injury, bones and muscles pain, the disease such as menoxenia and tetany.”

Herba speranskiae tuberculatae, formal name used at school: Phryma leptostachyaL. has another name called distiller’s yeast grass, Staggergrass etc.Part of being used as medicine is plant herb.So that herb color is green, dry, matter is tender, free from admixture person is good.There are blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow.External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.

Rhizoma Homalomenae formal name used at school: Homalomena occulta, English name: RHIZOMA HOMALOMENAE.Araeceae Rhizoma Homalomenae belongs to herbaceos perennial.Gas is fragrant, acrid in the mouth, micro-hardship.Property pungent, temperature.Mild toxicity.Be included into liver; Kidney; Stomach warp.There is the effects such as wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving, detumescence.Can dispelling the wind and dampness pathogens arthralgia pain, podomere acid is educated, muscles and bones flaccidity is soft, traumatic injury, stomachache, carbuncle skin ulcer are swollen.

Zaocys dispels the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.Naja, Agkistrodon halys have been poisonous snake, and wind-damp dispelling, the meridian dredging effect are comparatively strong, and Zaocys and the two same use, it knowingly follows the example of a wrongdoer good.For rheumatic arthralgia or rheumatoid arthritis, poker back etc.Zaocys 1, soup is boiled in section.Add leaf fat, salt, a little seasoning of Rhizoma Zingiberis Recens, meat eaten by drink soup.Zaocys has expelling wind and removing dampness and Detoxication, also has certain prevention or therapeutic effect for urticaria, eczema abscess.We and make soup thick soup to boil, be especially suitable for edible.

Radix Aconiti Preparata is pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.How to use after the process of preparing Chinese medicine.

Oleum Sesami is the fatty oil squeezed from Hu section plant sesame seed, and general Semen Sesami Nigrum takes, and Semen sesami Albae extracts oil.Meridian distribution of property and flavor: sweet, cool, nontoxic.Chemical composition: in Oleum Sesami, main component is unsaturated fatty acid, accounts for 85%-90%, oleic acid and linoleic acid respectively account for 50% substantially, are characterized in that stability is strong, and easily preserve, this is because containing a kind of Natural antioxidant---Semen Sesami acid in Oleum Sesami.Also containing mineral such as protein, sesamin, vitamin E, lecithin, sucrose, calcium, phosphorus, ferrum in Oleum Sesami, it is a kind of edible oil of vegetal pole horn of plenty.Effect: Chinese medicine is thought: this product nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.Record according in Compendium of Material Medica: " have moisturize, detoxify, pain relieving, detumescence merit." " not Lu " say: " sharp large intestine, afterbirth does not fall.Survivor's lump of rubbing swells, raw alopecia." clinically also decoct plaster with Oleum Sesami, there is granulation promoting meat, an effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.Containing sesamin in linum, when with siritch parch or bake dish or food, the compound of sesamin and the acid of decomposable asymmetric choice net (+) Semen Sesami and some fragrance, these fragrance matters can volatilize at normal temperatures, its aromatic flavor, elegant, tempting appetite are that other similar vegetable oil all hardly match.

The preparation of externally used paste of the present invention:

First just Cortex Cinnamomi 1500g, Olibanum 1500g, Rhizoma Et Radix Notopterygii 1500g, Sanguis Draxonis 1500g and Rhizoma Homalomenae 1500g steaming process are distilled into crystalline particle, pulverize 100 order dusting covers for subsequent use, again by Radix Gentianae Macrophyllae 1500g, Radix Angelicae Dahuricae 1500g, Radix Angelicae Pubescentis 1500g, Cortex Illicii 1500g, Radix Clematidis 1500g, Radix Saposhnikoviae 1500g, Herba Lycopodii 1500g, Rhizoma Drynariae 1500g, Radix Salviae Miltiorrhizae 1500g, geranium 1500g, Eupolyphaga Seu Steleophaga 1500g, Pheretima 1500g, Radix Dipsaci 1500g, Flos Carthami 1500g, Radix Tripterygii Wilfordii 1500g, Radix Aconiti Preparata 1500g, Scorpio 1500g, Herba speranskiae tuberculatae 1500g, Rhizoma Polygoni Cuspidati 1500g, Semen Strychni 1500g, Ramulus Et Folium Picrasmae 1500g, Zaocys 1500g, Cortex Lycii 1500g is cut into granule, add in the Oleum Sesami accounting for its 5-10 times weight portion and soak 3-7 days, heating extraction, first big fire is boiled, after Oleum Sesami boiling, firepower reduces, endure to pharmaceutical presentations be dark brown, inner coke yellow, pull medicinal residues out, medicine oil is continued to temper, and constantly stir, refining is to the beading that drips, again Plumbum preparatium is fried to vermilion, removing moisture, cross 100 mesh sieve removing impurity, Plumbum preparatium is slowly added in the medicine oil refined, constantly stir, become the thick paste of black, again the crystallization of pulverizing is stirred in the slightly cold rear impouring cold water of the plaster refined, soak 5-10 days, change water every day once, releasing fire-toxin.Then the crystalline particle of pulverizing is added in plaster, stir.

The preparation of externally used paste of the present invention:

First just Cortex Cinnamomi 1500g, Olibanum 1500g, Rhizoma Et Radix Notopterygii 1500g, Sanguis Draxonis 1500g and Rhizoma Homalomenae 1500g steaming process are distilled into crystalline particle, pulverized 100 order dusting covers for subsequent use, again by Radix Gentianae Macrophyllae 1500g, Radix Angelicae Dahuricae 1500g, Radix Angelicae Pubescentis 1500g, Cortex Illicii 1500g, Radix Clematidis 1500g, Radix Saposhnikoviae 1500g, Herba Lycopodii 1500g, Rhizoma Drynariae 1500g, Radix Salviae Miltiorrhizae 1500g, geranium 1500g, Eupolyphaga Seu Steleophaga 1500g, Pheretima 1500g, Radix Dipsaci 1500g, Flos Carthami 1500g, Radix Tripterygii Wilfordii 1500g, Radix Aconiti Preparata 1500g, Scorpio 1500g, Herba speranskiae tuberculatae 1500g, Rhizoma Polygoni Cuspidati 1500g, Semen Strychni 1500g, Ramulus Et Folium Picrasmae 1500g, Zaocys 1500g, Cortex Lycii 1500g is cut into granule, add and account for its quality 5 ~ 8 times amount alcohol heating reflux and extract 2 times, described each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 5 ~ 8 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, the medicinal residues that above-mentioned ethanol extraction is crossed are added water heating 1 ~ 2 hours reflux accounting for its quality 10 times amount and extract 2 times, extraction time is 2 hours, 1 hour, merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, one-tenth extractum stand for standby use, in described steps d, above-mentioned 2 kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.50, reduce pressure to obtain extractum, add the crystalline powder prepared, the glycerol that is in harmonious proportion stirs furnishing emulsifiable paste.

The preparation of unguentum of the present invention:

First just Cortex Cinnamomi 1200g, Olibanum 1300g, Rhizoma Et Radix Notopterygii 1200g, Sanguis Draxonis 1200g and Rhizoma Homalomenae 1200g steaming process are distilled into crystalline particle, pulverized 100 order dusting covers for subsequent use, again by Radix Gentianae Macrophyllae 1200g, Radix Angelicae Dahuricae 1200g, Radix Angelicae Pubescentis 1200g, Cortex Illicii 1100g, Radix Clematidis 1300g, Radix Saposhnikoviae 1200g, Herba Lycopodii 1200g, Rhizoma Drynariae 1100g, Radix Salviae Miltiorrhizae 1200g, geranium 1100g, Eupolyphaga Seu Steleophaga 1200g, Pheretima 1300g, Radix Dipsaci 1200g, Flos Carthami 1200g, Radix Tripterygii Wilfordii 1200g, Radix Aconiti Preparata 1200g, Scorpio 1300g, Herba speranskiae tuberculatae 1200g, Rhizoma Polygoni Cuspidati 1200g, Semen Strychni 1200g, Ramulus Et Folium Picrasmae 1200g, Zaocys 1200g, Cortex Lycii 1200g is cut into granule, put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, extracting solution is left standstill.The raw medicinal material crossed by ethanol extraction adds water heating and refluxing extraction 1 time, each 1 ~ 2 hour; Then 2 kinds of extracting solution are merged and leave standstill.Merged by above-mentioned two kinds of extracting solution, will merge in the extracting solution suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Three filtrates be combined, heating is concentrated into pasty state, the distillation crystalline powder of mediation preparation, is in harmonious proportion and spreads on the joint that swells and ache, paste medicine part, need clean, fix with preservative film, medical adhesive tape with wine, vinegar, Mel.Can tolerate as degree with patient, take off after general 5h, every day 1 time.

Patient's wash clean patient part, pasted potion breast of the present invention and was affixed on affected part, take off after 24 hours every night.External posts agent of the present invention can 25 days be use a course for the treatment of, and not easily pollution clothes, easy to use, fast.

Pharmacological toxicity is tested

Below in conjunction with zoopery and detection data, beneficial effect of the present invention is further described: acute oral toxicity test is reported

One, experiment purpose: detect the present invention to the acute oral toxicity effect of mice and intensity

Two, materials and methods:

1. tested material: unguentum of the present invention; Character: pitchy paste

2. sample pre-treatments: take 15 parts of sample powder, add 500ml boiled water, soaks 2 hours, as stock solution.

3. experimental animal: one grade of Kunming mouse, 20, female, hero half and half, body weight 18-22 gram; Thered is provided by biology department of Shandong University Experimental Animal Center;

Three, test method: (maximum limit is mensuration)

Select healthy adult mice 20, body weight 18-22 gram, female, hero half and half, dose design is female is 6000m part/k part BW, and male is 6000m part/k part BW, gives tested material by 0.1ml/10 part BW per os gavage.Before gavage, animal fasting 12 hours, freely drinks water.Give normal diet after gavage, observe two weeks, record poisoning symptom and death condition.

Four, result of the test:

In 14 day observation period, animal subject reaction without exception, without dead, postmortem no abnormality seen.Female, male mice acute oral LD 50 is greater than 5000m part/k part/BW.

Five, conclusion:

Judge according to acute toxicity grading criteria in " disinfection technology standard " (1999), the nontoxic level in the true border of externally used paste of the present invention.

Cumulative toxicity test is reported

One, test method: (dosage escalation cumulative coefficient method)

Experiment material: the same is kunming mice.Select 20 healthy mices, female, each 10 of hero, dose design is first phase in every 4 days, each issue dosage is respectively 0.10LD 50,0.15LD 50,0.22LD 50,0.34LD 50,0.50LD 50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 4 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, calculates cumulative coefficient.

Two, result of the test:

By ascending-dose to tested material 20 days handss, female, buck all occurs without death condition.Calculate cumulative coefficient and be greater than 5.

Three, brief summary:

Judge according to cumulative toxicity grade scale in " disinfection technology standard " (1999), unguentum of the present invention belongs to weak cumulative toxicity to mice cumulative toxicity.

Acute skin irritation test is reported

One, experiment purpose: detect unguentum to the stimulation/corrosiveness of laboratory animal skin and intensity

Two, materials and methods:

1. tested material: title: unguentum of the present invention

2. laboratory animal: one grade of large ear white race rabbit, 4, female, body weight 2.1-2.3k part; Thered is provided by biology department of Shandong University Experimental Animal Center;

3. test method:

The healthy family selecting skin intact exempts from 4, within first 24 hours, is cut its spinal column both sides, back by hair in test, the left and right each about 3cm × 3cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and mark.

Three, experimental result:

Four, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), unguentum of the present invention belongs to nonirritant to animal skin stimulus intensity.

Vaginal mucomembranous irritant test is reported

One, experiment purpose: detect disinfectant to the stimulation of laboratory animal vaginal mucosa and intensity

Two, materials and methods:

1. tested material: title: unguentum of the present invention

2. laboratory animal: one grade of large ear white race rabbit, 4, female, body weight 2.1-2.3k

Part; Thered is provided by biology department of Shandong University Experimental Animal Center;

3. test method:

After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, be divided into three groups at random, often organize each 6, be respectively: blank, excipient control, tested material group (by application liquid 5 times of concentration).Be placed in excipient control group and the intravaginal of tested material treated animal with the sterilizing cotton sliver leaching of suitable size with sterile saline and tested material respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Taking-up topical vaginal tissue, observes pathological changes situation.

Three, result of the test:

Judge according to " disinfection technology standard " (1999) medial vagina mucomembranous irritant test evaluation criterion, unguentum of the present invention has no stimulation to rat vagina mucosa.

Other test result: under 20-21 DEG C of water bath condition, show through three repeated trials results, unguentum 1.50% solution effects 20min of the present invention, be 99.90%, 3.00% solution effects 10min killing rate to Candida albicans (ATCC10231) killing rate be 99.94%, 1.5% solution effects 15min, is 99.94% to escherichia coli (8099), staphylococcus aureus (ATCC6538) killing rate.

Under 20-21 DEG C of water bath condition, show through three repeated trials results, when 25% and 50% calf serum exists, unguentum 1.5% solution of the present invention, on escherichia coli (8099) killing action without impact.

Skin anaphylactic test

According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", skin anaphylactic test is carried out to medicine of the present invention.

Tested material: unguentum of the present invention.Weighing tested material 10g adding distil water, to make 50% pastel for subsequent use.Positive control: 2,4-dinitro-chloro-benzene, produce in Xing Jin chemical plant, Beijing, lot number 20020522.Laboratory animal: provide Cavia porcellus 30 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 250-300g, primary animal, feed resource is the same.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.Test method: test Cavia porcellus is divided into three groups at random, often organize 10, male and female half and half, are respectively tested material group, negative control group and positive controls.

Sensitization contact: removed by guinea pig back left of spine hair for first 24 hours to tested material, unhairing scope is about 3cm × 3cm.Get tested material 0.2g/ only, be coated in district of losing hair or feathers on the left of back part of animal after preparation, continue 6 hours.7th day and fortnight, repeat once with same method, and positive controls is coated with 1%DNCB, and negative control group does not deal with.Excite contact: fortnight after last is to tested material, by tested material 0.2g/ only, be coated on district of losing hair or feathers on the right side of guinea pig back after preparation, remove tested material after 6 hours, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hour.Positive controls is coated with 1%DNCB, and negative control group does not deal with.Observational technique is with tested material group.

Result of the test: skin anaphylactic test shows unguentum of the present invention, according to according to sensitization of skin intensity evaluation standard relevant in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the invention belongs to without sensitization.

Experimental example 6, anti-inflammation test, analgesic test, microcirculation test

Anti-inflammation test: tested group of mouse ear inflammation swelling is less than blank group, and difference has significance (P<0.05), illustrates that unguentum of the present invention has certain antiinflammatory action.Analgesic test: tested group of mouse writhing number of times reduces than blank group, and difference has significance (P<0.05).Illustrate that unguentum of the present invention has certain analgesic activity.

Microcirculation test: tested group of Mice Auricle fine motion, vein bore and capillary vessel number all comparatively blank group obviously increase, and difference all has highly significant (P<0.01), illustrate that unguentum of the present invention has and improve the microcirculatory effect of Mice Auricle.

Pharmacological experiment illustrates:

Healthy mice 30 is got in the impact of a pair Oleum Tiglii induced mice auricle edema, be divided into 3 groups at random, i.e. blank group, positive controls, plaster group of the present invention, often organize 10, male and female half and half, Herba Sarcandrae positive controls and drug component other gastric infusion (ig) 8g crude drug/kg, the isodose normal saline of blank group gavage, successive administration 3 days, after last administration 0.5 hour, survey outward at the left in ear of mice and be coated with Oleum Tiglii proinflammatory agent (2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, cause inflammation and lay a left side with card punch (aperture 6mm) in latter 4 hours, auris dextra sheet, weigh, using left and right auricle weight difference as swelling degree, the results are shown in Table 1.

Table 1 is on the impact (X ± SD) of Oleum Tiglii induced mice auricle edema

Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; As can be seen from upper table experimental result, medicine of the present invention has better pharmacological action.

Two. the impact of rat paw edema caused by Carrageenan

Get healthy rat 30, body weight 180-220g, be divided into blank group, Herba Sarcandrae positive controls, medicine group of the present invention at random.Often organize 10, male and female half and half, sub-cage rearing.Positive controls and the other gastric infusion 8g/kg of drug component of the present invention, blank group gives the normal saline of same dosage, successive administration 3 days, after last administration 30 minutes, only inflammation is caused respectively at Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/, respectively at cause scorching before and cause scorching after within 15,30,60,120,240 minutes, survey the girth of the Rat Right metapedes sole of the foot, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth × 100%]; The results are shown in Table 2.

The impact (X ± SD) of rat paw edema caused by table 2 on Carrageenan

Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; As can be seen from upper table experimental result, medicine group of the present invention has better pharmacological action.

Clinical pharmacology drug effect:

1, the routine patient of clinical data 100, man 54 example, female 46 example; The oldest 68 years old, minimum 18 years old, 18 years old ~ 50 years old 68 example; 58 examples of the course of disease within 1 month, 1 month ~ 3 months 12 examples, 4 months ~ 6 months 8 examples, 7 months ~ 12 months 9 examples, more than 1 year 13 example; There are 55 examples of obvious trauma history, chronic strain 57 example, agnogenio 7 examples; One-sided 67 examples, bilateral 54 example; Without any treatment 57 example in 100 routine patients, once, hand-manipulating of needle moxibustion, take medicine, the treatment such as physical therapy, the person of being not improved 23 example.

2, Therapeutic Method

The each 15g of 2.1 external used medicine of the present invention.Mixing is placed in pulverizer and breaks into powder, dries and is loaded in gauze bag.When putting into traditional Chinese medicine steam therapy instrument internal therapy, temperature range is 0 ~ 45 DEG C.Patient keeps about 20min find the posture oneself feeling comfortable in treatment cabin after, and the time can not be oversize, in case other symptoms appear in patient, 1 time/d, 1 course for the treatment of is 25d.Or externally used paste is heated, be in harmonious proportion spread on swelling and pain in knee joint with wine, vinegar, Mel, pasting medicine part need clean, and fixes with preservative film, medical adhesive tape.

2.2 matched groups: matched group adopts unblocking collaterals to treat arthritis to paste are produced by Jilin Wan Tong Pharmaceutical group, Ji Weijian No. 024th, word (2006).Alleviate the pain that femur head necrosis, hyperosteogeny, cervical spondylosis, lumbar spondylosis, intervertebral disk hernia, rheumatic arthritis, ankylosing spondylitis, scapulohumeral periarthritis, traumatic injury, Senile osteoarthritis etc. cause, promote its rehabilitation.Suitable population: be applicable to because of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, lumbar muscle strain, hyperosteogeny, traumatic injury, the pain that prolapse of lumbar intervertebral disc etc. cause and lumbago and skelalgia, sciatica.Skin is cleaned and dries, remove adherent layer, be attached to sore spot.One pastes 2--3 days, and 4 paste 12 staggering amounts.1 time/d, 1 course for the treatment of is 25d.

3 efficacy analysis

3,1 criterion of therapeutical effect

Recovery from illness: after treating for 1 course for the treatment of, sings and symptoms all disappears, and joint motion is normal; Take a turn for the better: it is normal to treat sings and symptoms and joint motion after 1 course for the treatment of; Invalid: after treating for 1 course for the treatment of, sings and symptoms and joint motion are not improved before comparatively treating.Calculate the average improvement amplitude of the whole Clinical symptom and sign of each patient, to judge the clinical efficacy of RA patient: 1. clinic control or in early days healing: symptomatology on average improves more than 75%, or recover normal completely, RF, ESR recover normal; 2. effective: symptomatology on average improves more than 50%, RF, ESR and all reduces or recover normal; 3. effective: symptomatology on average improves more than 10%; 4. invalid: clinical symptoms is improved amplitude and is less than 10%, or occurs negative value.

3,2 therapeutic outcomes, in table 1.

Two groups of Comparison of therapeutic (%)

Discuss: synovitis is the aseptic inflammation because microcirculation does not freely cause; cardinal symptom produces hydrops, and synovium of joint surrounds periarticular skim tissue, and it is not only the tissue of one deck Saving cortilage; but also can joint fluid be produced, for the activity in joint provides " lubricating fluid ".The generation of joint fluid and absorption are one " dynamic equilibrium ", and when there is heavy malabsorption to joint fluid, because the generation of joint fluid and absorption dynamic equilibrium are broken, the generation of joint fluid is greater than and heavily absorbs, and just there will be " hydrarthrosis ".So treatment synovitis mainly nurses one's health microcirculqtory system, as long as microcirculation is unimpeded, hydrops also just circulates and disappears, same inflammation also just relieves, fatigue of trying not during hydrops, reduces the frequency of drawing liquid injection, too much injection of drawing water can stimulate the fibroplasia of subsynovial connective tissue group, and synovial tissue is aging etc., synovial tissue's renewable reservoir ability is significantly reduced, then treatment is just cumbersome.

Detailed description of the invention:

Embodiment: Wu, man, 22 years old, basket baller, sprain knee during readme match, right knee had an intense pain, and film making is abnormal.Ibuprofen oral and SHANGSHI ZHITONG GAO external application, pain slightly alleviates, within 5 days, find knee swelling afterwards, there is edema hydrops, limitation of activity, go to hospital to extract hydrops and take a turn for the better not yet, use YUNNAN BAIYAO cream, spraying, naturopathy invalid for February, then arrive me section to go to a doctor, diagnosis: traumatic right gonarthromeningitis, external used medicine is made plaster and is used:

External used medicine: Radix Gentianae Macrophyllae 13g, Radix Angelicae Dahuricae 13g, Radix Angelicae Pubescentis 12g, Cortex Cinnamomi 11g, Cortex Illicii 13g, Radix Clematidis 12g, Radix Saposhnikoviae 13g, Herba Lycopodii 13g, Rhizoma Drynariae 12g, Radix Salviae Miltiorrhizae 11g, geranium 11g, Eupolyphaga Seu Steleophaga 13g, Pheretima 14g, Sanguis Draxonis 13g, Olibanum 12g, Radix Dipsaci 13g, Rhizoma Et Radix Notopterygii 12g, Flos Carthami 13g, Rhizoma Homalomenae 13g, Radix Tripterygii Wilfordii 14g, Radix Aconiti Preparata 12g, Scorpio 13g, Herba speranskiae tuberculatae 13g, Rhizoma Polygoni Cuspidati 13g, Semen Strychni 12g, Ramulus Et Folium Picrasmae 13g, Zaocys 13g, Cortex Lycii 12g.

Mixing is placed in pulverizer and breaks into powder, dries and is loaded in gauze bag.Temperature 45 C when putting into traditional Chinese medicine steam therapy instrument internal therapy, keeps about 20min.1 time/d, 1 course for the treatment of is 25d.Or externally used paste is heated, be in harmonious proportion spread on swelling and pain in knee joint with wine, vinegar, Mel, pasting medicine part need clean, and fixes with preservative film, medical adhesive tape.Use after 30 days, patient's knee joint swelling pain and numb disappearance, walk as usual, check erythrocyte sedimentation rate 15mm/h.For consolidate curative effect, then use 3 months.Recovery from illness is followed up a case by regular visits to after 1 year.

Claims

1. treat the Chinese medicinal external-application ointment of gonarthromeningitis for one kind, it is characterized in that, described externally used paste comprises the raw material of following parts by weight: Radix Gentianae Macrophyllae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Cortex Illicii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Ramulus Et Folium Picrasmae 10 ~ 20 parts, Zaocys 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts.

2. treat the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 1, it is characterized in that, described externally used paste comprises the crude drug of following parts by weight: Radix Gentianae Macrophyllae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Cortex Illicii 10 ~ 15 parts, Radix Clematidis 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, Herba Lycopodii 10 ~ 15 parts, Rhizoma Drynariae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, geranium 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Olibanum 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 20 parts, Radix Tripterygii Wilfordii 10 ~ 20 parts, Radix Aconiti Preparata 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba speranskiae tuberculatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Ramulus Et Folium Picrasmae 10 ~ 20 parts, Zaocys 10 ~ 20 parts, Cortex Lycii 10 ~ 20 parts.

3. treat the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 1, it is characterized in that, described externally used paste comprises the crude drug of following parts by weight: Radix Gentianae Macrophyllae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Cortex Illicii 10 ~ 20 parts, Radix Clematidis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Herba Lycopodii 10 ~ 20 parts, Rhizoma Drynariae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, geranium 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Olibanum 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Rhizoma Et Radix Notopterygii 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Rhizoma Homalomenae 10 ~ 15 parts, Radix Tripterygii Wilfordii 10 ~ 15 parts, Radix Aconiti Preparata 10 ~ 15 parts, Scorpio 10 ~ 15 parts, Herba speranskiae tuberculatae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, Ramulus Et Folium Picrasmae 10 ~ 15 parts, Zaocys 10 ~ 15 parts, Cortex Lycii 10 ~ 15 parts.

4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicinal external-application ointment of gonarthromeningitis, it is characterized in that, the preparation method of described unguentum comprises:

B. more soaked crude drug is heated in Oleum Sesami and temper;

D. the ointment made is put into releasing fire-toxin in cold water;

5. treat the preparation method of the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 4, it is characterized in that, in described step a, get crude drug and add in the Oleum Sesami accounting for its 5-10 times weight portion and soak 7-10 days.

6. treat the preparation method of the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 4, it is characterized in that, in described step b, by soaked for Oleum Sesami crude drug heating extraction, big fire is boiled, Oleum Sesami boiling after firepower reduce, endure to crude drug appearance be dark brown, inner coke yellow, pull medicinal residues out, continued to temper by medicine oil, and constantly stir, refining is to dripping into pearl.

7. treat the preparation method of the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 4, it is characterized in that, in described step c, Plumbum preparatium is fried to dark yellow, removing moisture, cross 100 mesh sieve removing impurity; Added in the medicine oil refined, constantly stirred, become the thick paste of black.

8. treat the preparation method of the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 4, it is characterized in that, in described steps d, by impouring cold water after the cooling of black thick paste, soak 5-10 days, change water every day once, releasing fire-toxin.

9. treat the preparation method of the Chinese medicinal external-application ointment of gonarthromeningitis according to claim 4, it is characterized in that, in described step e, Cortex Cinnamomi, Olibanum, Rhizoma Et Radix Notopterygii, Sanguis Draxonis and Rhizoma Homalomenae steaming process are distilled into crystalline particle, pulverized 100 order dusting covers, and then added in the ointment that makes and stir.

10. according to any one of claim 1-9, treat the Chinese medicinal external-application ointment of gonarthromeningitis, it is characterized in that, by externally used paste heating of the present invention during use, be in harmonious proportion spread on swelling and pain in knee joint with wine, vinegar, Mel, paste medicine part need clean, fix with preservative film, medical adhesive tape.