CN106074813A - A kind of Chinese medicine fumigation and washing soaking agent treating talalgia and preparation method thereof - Google Patents
A kind of Chinese medicine fumigation and washing soaking agent treating talalgia and preparation method thereof Download PDFInfo
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Abstract
nullThe present invention provides a kind of Chinese medicine fumigation and washing soaking agent treating talalgia,Including following crude drug: Flos Carthami 10~20 parts,Spina Gleditsiae 10~20 parts,Rhizoma Drynariae 10~20 parts,The Cortex Eucommiae 10~20 parts,Rhizoma Corydalis 10~20 parts,Caulis Spatholobi 10~20 parts,Herba Lycopodii 10~20 parts,Radix Clematidis 10~20 parts,Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~20 parts,Radix Dipsaci 10~20 parts,The Radix Angelicae Dahuricae 10~20 parts,Radix Stephaniae Tetrandrae 10~20 parts,Rhizoma Chuanxiong 10~20 parts,Herba speranskiae tuberculatae 10~20 parts,Radix Notoginseng 10~20 parts,Myrrha 10~20 parts,Olibanum 10~20 parts,Rhizoma Et Radix Notopterygii 10~20 parts,Pheretima 10~20 parts,Eupolyphaga Seu Steleophaga 10~20 parts,Radix Saposhnikoviae 10~20 parts,Cortex Acanthopancis 10~20 parts,Radix Angelicae Pubescentis 10~20 parts,Caulis Sargentodoxae 10~20 parts,Fructus Zanthoxyli 10~20 parts.With the passing of time or from the beginning of talalgia, select the herbal medicine immersion foot of numerous expelling wind and removing dampness, dispelling cold by warming the meridian, softening hardness and disperse swelling, invigorating blood circulation analgesia, not injured skin, without toxicity.
Description
Technical field
The present invention relates to, containing the pharmaceutical product deriving from plant, animal or mineral component, treat particularly to one
Chinese medicine fumigation and washing soaking agent of talalgia and preparation method thereof.
Background technology
Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, gas
Blood is with smoothness balance for expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in qi-blood circulating
Deterioration, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be with QI and blood as guiding principle, be allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing,
Unsting and invigorate blood circulation.Talalgia is one of common ailment of middle-aged and old, usually heel portion pain occurs without obvious inducement, difficulty in walking, and
Substantially increase the weight of after walk load for its feature, to have a strong impact on the life of middle-aged and elderly people.Talalgia name of disease is with heel portion pain
The disease of name.Heel portion is the major part that human body bears a heavy burden, and has following anatomical features: heel skin is portion the thickest in human body
Position, its subcutaneous fat is fine and close and flourishing, also known as fat pad.With the presence of synovial bursa between fat and calcaneus.Sole of the foot fascia and toe are short in the wrong
Flesh is attached to calcaneal tuberosity front, and heel string is attached to the back upper place of calcaneal tuberosity in the form of sheets.
With advancing age, organism quality declines middle-aged and elderly people, and heel tissue strains through long-term chronic, fat pad etc.
Tissue dewatering, atrophy, regression;Elastic reduce, simultaneously year the age increase skeleton decalcification gradually occur, plantar aponeurosis, heel string etc. is inadaptable
Tense situation during walking, often damages the most slight courage and uprightness at calcaneus attachment and oozes because being not suitable with tractive for a long time
Go out, be with the passing of time excited into ostosis hyperosteogeny and produce bony spur.In addition synovial membrane repeatedly rubs and also may result in the thorn such as synovial bursae inflammation
There is pain in sharp sensory nerve.The traditional Chinese medical science thinks that middle-aged and elderly people kidney qi is gradually lost, and bone withers flaccidity of tendon and muscle, and QI and blood can not be moistened in foot, and exopathogen is taken advantage of
Machine numbness hinders passages through which vital energy circulates and causes pain.Surely belong to " arthromyodynia " category.
With the passing of time or from the beginning of talalgia, select the Chinese medicine of numerous expelling wind and removing dampness, dispelling cold by warming the meridian, softening hardness and disperse swelling, invigorating blood circulation analgesia
Soak or external application foot, not injured skin, without toxicity.Fumigation and wash method decocted by all liquid medicine, and medicine acts on local, permeates flesh
Skin, through sick institute, promote qi and blood circulation, improve local blood and run, soften bony spur, promote that inflammation absorbs, so that symptom is delayed
Solve or eliminate.
The modal reason of talalgia is that long-term, chronic, microtrauma accumulates the pathological changes caused, and shows as fascia fiber
Fracture and repair process thereof.Below calcaneus partially in fascia vicinity can have a hyperosteogeny, form bone ridge.At position, side roentgenogram
Bony spur it is shown as on sheet.The latter is considered as often the reason of talalgia, but clinical research proves the cause effect relation of it and talalgia
Being difficult to certainly, plantar fasciitis differs and establishes a capital with bony spur, has the people of calcanean spur also to differ and established a capital talalgia.Plantar fasciitis draws
The talalgia risen can be cured naturally.Padded heel, alleviates the heel string pulling force to calcaneus, front plantar flexion of foot, alleviates opening of sole of the foot fascia
Power, all can make symptom alleviate.Injection of drug can be carried out by local pressure pain point inside foot root, once in a week, most after injection
Patient can cure in two weeks.
From the angle analysis of the traditional Chinese medical science, talalgia belongs to the one of rheumatism involving the bone, how because of the hepatic and renal YIN deficiency, caused by cold-evil.Talalgia is
A kind of disease that old people is common, but the sickness rate in young woman rises year by year now, particularly as white collar clan, on
The cooling slippers of fashion style is worn by class, and heel minister's phase exposes, and easily by attacked by the cold and evil in air-conditioned room, is After Hours busy with strolling
Street, jumping slimnastics, foot fails again well to be had a rest, and due to the long-term pressurized of heel, hyperkinesia with have a cold, causes foot
With fat fiber mat aseptic inflammation, finally induce pain.
Kidney is unit's the dominator of QI, kidney governing reproduction, main bone.According to meridians circulation route, heel belongs to the scope of kidney channel circulation.Heel
Pain is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia is also known as calcanean spur
Or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains with old deficiency of the kidney, wound and experience cold-damp
Relevant.With the passing of time or from the beginning of talalgia, select the herbal medicine immersion of numerous expelling wind and removing dampness, dispelling cold by warming the meridian, softening hardness and disperse swelling, invigorating blood circulation analgesia
Or external application foot, not injured skin, without toxicity.
Traditional Chinese Medicine early has research to the disease of talalgia, and Sui Dynasty famous physician Chao Yuanfang (550-630 A.D.) talalgia is called " heel is ruined ",
Book cloud: " heel ruined person heel neglect pain, must not also, common customs are exhaled as heel ruined." the big physician Zhu Dan of one of Au element
Small stream is referred to as " talalgia " in " danxi's experiential therapy ", it is necessary to use the attached cream in osmanthus.The Qing Dynasty's famous physician Xu Ling tire is said: " modern used
Plaster, the plaster applying a plaster for therapeutic purpose of ancients' meaning..... control inner person, or wind dispelling trembled with fear, or and QI and blood, or expectorant painful abdominal mass, or strengthening bone and muscle, its side is very clever,
Medicine is also added and subtracted with disease, and its cream preferably weighs thick patch for a long time.”
Doctor trained in Western medicine typically solves this problem with operation, though there being certain curative effect, but plants destructive operation, by calcaneus posterior tibial nerve
Prop up and sural nerve props up cut-out, have side effect in various degree or cause some complication;Chinese medicine product is then because of its sky of drawing materials
So, safety side effect good, low, documents and materials are abundant, clinical efficacy is good and enjoys favor.But existing prescription specific aim is poor,
Can not fundamentally alleviate the symptom of talalgia, and the most certain side effect.Therefore, the Chinese medicine of a kind of highly effective and safe is found
Compositions becomes the urgent needs of people.
Summary of the invention
The technical problem to be solved is, talalgia is a kind of commonly encountered diseases, with heel swelling, numb pain,
Locally tenderness, difficulty in walking are characterized.Talalgia is also known as calcanean spur or heel bone hyperosteogeny." rheumatism involving the bone " model is belonged in Chinese medicine
Farmland, pathogenic factor is many strains with old deficiency of the kidney, and wound is with to experience cold-damp relevant.Doctor trained in Western medicine typically solves this problem with operation, though having
Certain curative effect, but plant destructive operation, calcaneus posterior tibial nerve is propped up and props up cut-out with sural nerve, have side effect in various degree
Or cause some complication;Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical
Curative effect is good and enjoys favor.With the passing of time or from the beginning of talalgia, select numerous expelling wind and removing dampness, dispelling cold by warming the meridian, softening hardness and disperse swelling, town of invigorating blood circulation
Pain herbal medicine immersion or external application foot, not injured skin, without toxicity.Fumigation and wash method decocted by all liquid medicine, and medicine acts on local,
Infiltration skin, through sick institute, promote qi and blood circulation, improve local blood and run, soften bony spur, promote that inflammation absorbs, so that
Remission or elimination.Therefore, the Chinese medicine fumigation and washing soaking agent finding a kind of highly effective and safe becomes the urgent needs of people.
For solving these technical barriers, the invention provides a kind of Chinese medicine fumigation and washing soaking agent treating talalgia, described in it
Chinese medicine fumigation and washing soaking agent can include the crude drug of following parts by weight: Flos Carthami 10~20 parts, Spina Gleditsiae 10~20 parts, Rhizoma Drynariae
10~20 parts, the Cortex Eucommiae 10~20 parts, Rhizoma Corydalis 10~20 parts, Caulis Spatholobi 10~20 parts, Herba Lycopodii 10~20 parts, Radix Clematidis 10~
20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~20 parts, Radix Dipsaci 10~20 parts, the Radix Angelicae Dahuricae 10~20 parts, Radix Stephaniae Tetrandrae 10~20 parts, Rhizoma Chuanxiong 10~20 parts, Herba speranskiae tuberculatae
10~20 parts, Radix Notoginseng 10~20 parts, Myrrha 10~20 parts, Olibanum 10~20 parts, Rhizoma Et Radix Notopterygii 10~20 parts, Pheretima 10~20 parts, soil
Trionyx sinensis Wiegmann worm 10~20 parts, Radix Saposhnikoviae 10~20 parts, Cortex Acanthopancis 10~20 parts, Radix Angelicae Pubescentis 10~20 parts, Caulis Sargentodoxae 10~20 parts, Fructus Zanthoxyli 10~20
Part.
The Chinese medicine fumigation and washing soaking agent of described treatment talalgia, its described Chinese medicine fumigation and washing soaking agent can also include following weight
The crude drug of number: Flos Carthami 10~20 parts, Spina Gleditsiae 10~20 parts, Rhizoma Drynariae 10~20 parts, the Cortex Eucommiae 10~20 parts, Rhizoma Corydalis 10
~20 parts, Caulis Spatholobi 10~20 parts, Herba Lycopodii 10~20 parts, Radix Clematidis 10~20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~20 parts, Radix Dipsaci 10~20
Part, the Radix Angelicae Dahuricae 10~20 parts, Radix Stephaniae Tetrandrae 10~20 parts, Rhizoma Chuanxiong 10~20 parts, Herba speranskiae tuberculatae 10~20 parts, Radix Notoginseng 10~20 parts, Myrrha 10
~20 parts, Olibanum 10~20 parts, Rhizoma Et Radix Notopterygii 10~20 parts, Pheretima 10~20 parts, Eupolyphaga Seu Steleophaga 10~20 parts, Radix Saposhnikoviae 10~20 parts, five
Cortex Acanthopanacis Radicis 10~20 parts, Radix Angelicae Pubescentis 10~20 parts, Caulis Sargentodoxae 10~20 parts, Fructus Zanthoxyli 10~20 parts.
The Chinese medicine fumigation and washing soaking agent of described treatment talalgia, its described Chinese medicine fumigation and washing soaking agent can also include following weight
The crude drug of number: Flos Carthami 10~20 parts, Spina Gleditsiae 10~20 parts, Rhizoma Drynariae 10~20 parts, the Cortex Eucommiae 10~20 parts, Rhizoma Corydalis 10
~20 parts, Caulis Spatholobi 10~20 parts, Herba Lycopodii 10~20 parts, Radix Clematidis 10~20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~20 parts, Radix Dipsaci 10~20
Part, the Radix Angelicae Dahuricae 10~20 parts, Radix Stephaniae Tetrandrae 10~20 parts, Rhizoma Chuanxiong 10~20 parts, Herba speranskiae tuberculatae 10~20 parts, Radix Notoginseng 10~20 parts, Myrrha 10
~20 parts, Olibanum 10~20 parts, Rhizoma Et Radix Notopterygii 10~20 parts, Pheretima 10~20 parts, Eupolyphaga Seu Steleophaga 10~20 parts, Radix Saposhnikoviae 10~20 parts, five
Cortex Acanthopanacis Radicis 10~20 parts, Radix Angelicae Pubescentis 10~20 parts, Caulis Sargentodoxae 10~20 parts, Fructus Zanthoxyli 10~20 parts.
For solving above-mentioned technical problem, the present invention also provides for the preparation side of a kind of Chinese medicine fumigation and washing soaking agent treating talalgia
Method, it is characterised in that the preparation method of described Chinese medicine fumigation and washing soaking agent comprises the following steps:
A. take Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and the Rhizoma Et Radix Notopterygii way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as group
Divide 1.
B. the extraction of surplus stock medicinal alcohol is taken, as component 2;
C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 3;
D. by 2-in-1 for component 1 component and be condensed into extractum, add component 1 and stir and make granule, subpackage;With opening during use
Water brews.
In described step a, can first crude drug Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and Rhizoma Et Radix Notopterygii steam method be distilled,
To crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.
In described step b, remaining crude drug can be shredded, be soaked and be placed in lid stainless steel cask, add 70% second
Alcohol liquid, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand;By percolator
Drug sample after moistening expansion is mixed pine after paving and is done to dissipate by bottom filter plate gauze bag parcel again, then contains with rustless steel spoon
Powder, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitable
Working as pressurization, medicated powder loads 2/3 eminence that must not exceed percolator;Medicated powder face upper cover rustless steel orifice plate fastens, and opens under percolator
The baiting valve in face, and put a container, then it is slowly added into 70% ethanol;Air between medicated powder powder to be discharged, and have second
Alcohol flows out about about 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation
Speed is generally 1000g medical material outflow per minute 2~3ml, and filtrate puts into liquid container, and pours ethanol during emptying into storage
Fluid cylinder;Being merged by percolate and stand, stand for standby use, as component 2.
In described step c, can above-mentioned stripped raw material residue be put in 10 times amount water, soak 1-2 hour, heating
Extracting 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then through the molecular weight that dams be 5000-
The ultrafiltration post ultrafiltration of 10000, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 3.
In described step d, component 2 can be merged with component 3, put in economic benefits and social benefits vacuum concentrator and mix, first by filtrate
When being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0~5 DEG C of deepfreezes 24 hours;By helping that cold preservation liquid adds 0.3%
Filtering agent kieselguhr, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, adds component 1 and stirs
Uniformly make granule, subpackage;Brew with boiled water during use.
For solving above-mentioned technical problem, the present invention also provides for the preparation side of a kind of Chinese medicine fumigation and washing soaking agent treating talalgia
Method, the preparation process of described Chinese medicine fumigation and washing soaking agent can also be:
A. take Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and the Rhizoma Et Radix Notopterygii way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as group
Divide 1;
B. by remaining raw material ethanol extraction 2 times, concentrate, as component 2;
C. pelletize after component 1, component 2 being mixed, subpackage.
In described step a, can first crude drug Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and Rhizoma Et Radix Notopterygii steam method be distilled,
To crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1;In described step b, remaining crude drug can be steeped
Enter in 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-
120 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, and ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C
Time 1.25 filtrate, as component 2;In described step c, component 1 can be put in component 2, stir, make granule,
Subpackage;Brew with boiled water during use.
Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, gas
Blood is with smoothness balance for expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in qi-blood circulating
Deterioration, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be with QI and blood as guiding principle, be allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing,
Unsting and invigorate blood circulation.Fumigation and wash method decocted by all liquid medicine, and medicine acts on local, permeates skin, through sick institute, promotes qi and blood circulation, improve local
Blood operation, softens bony spur, promotes that inflammation absorbs, so that remission or elimination.
Detailed description of the invention
Traditional Chinese Medicine early has research to the disease of talalgia, and Sui Dynasty famous physician Chao Yuanfang (550-630 A.D.) talalgia is called " heel is ruined ",
Book cloud: " heel ruined person heel neglect pain, must not also, common customs are exhaled as heel ruined." the big physician Zhu Dan of one of Au element
Small stream is referred to as " talalgia " in " danxi's experiential therapy ", it is necessary to use the attached cream in osmanthus.
Tcm syndrome differentiation and treatment, classification therapy: 1. kidney yin deficiency type: foot shin intermittent fever and talalgia, add Carapax et Plastrum Testudinis, meat with pill of Six Ingredients
Osmanthus.2. kidney yang deficiency syndrome: can not standing for a long time and talalgia, with eight taste balls.3. wetness type: weigh and swell, with changing bone pellet, history state public affairs medicine
Wine.4. multiple abscess caused by damp-phlegm type: add Herba Lycopodii, Bi, Radix Stephaniae Tetrandrae with Daotan Tang.5. QIXUELIANGXU type: with BUZHONG YIQI TANG, medicinal piece of shiquan dabu
Soup.6. blood-heat type: add the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Achyranthis Bidentatae (see " Elementary Medicine tinea pedis ") by SIWU TANG.
Fumigation and wash method decocted by all liquid medicine, and medicine acts on local, permeates skin, through sick institute, promotes qi and blood circulation, improve local blood
Liquid runs, and softens bony spur, promotes that inflammation absorbs, so that remission or elimination.
Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, gas
Blood is with smoothness balance for expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in qi-blood circulating
Deterioration, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be with QI and blood as guiding principle, be allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing,
Unsting and invigorate blood circulation.
Radix Angelicae Pubescentis, Chinese medicine name.For samphire Angelica pubescens Angelica pubescens
The dry root of Maxim.f.biserrata Shan et Yuan.Acrid in the mouth, hardship, slightly warm in nature.Return kidney, bladder warp.Effect is dispeled the wind and is removed
Wet, arthralgia aggravated by cold pain relieving.Curing mainly for anemofrigid-damp arthralgia, pain to be washed, few the moon volt wind headache, wind and cold holds wet headache under the arm." book on Chinese herbal medicine converges and says ": solely
Living, benefaction blood system, the medicine of the wet cold expelling of row that dispels the wind is also.The card of all sick wind, as head term can not pitching, waist knee joint can not bend and stretch, or arthralgia pain
Be difficult to walk, numbness need not, all wind is caused with cold, and summer-heat is with wet institute wound also;Must be warm by the toil of Radix Angelicae Pubescentis, activity QI and blood, dispel scattered
Cold-evil, therefore " herbal " speech can dissipate tinea pedis, changes renal mass, treats hernia abdominal mass, subduing inflammation, controls harmful wind hundred joint and attacks pain, the strongly fragrant headache of YIN-cold less, meaning
At this.
Rhizoma Drynariae is bitter, temperature.Enter liver, kidney channel.Function cures mainly the kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatism numbness
Bitterly, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus." property of medicine opinion ": " poison in main bone, wind blood pain, five
Labor six types of severe debility disease, mouth (one make ' foot ') hands do not receives, upper heat and lower cold." " Japan hanako materia medica ": " controls malignant boil, loses rotten meat, parasite killing.″
Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping." day
China's son book on Chinese herbal medicine ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, row
Pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.
Pheretima: Compendium of Material Medica referred to as has dredge the meridian passage, blood circulation promoting and blood stasis dispelling, prophylactic treatment cardiovascular and cerebrovascular disease effect.
Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, half
Body is unsuccessful.
Flos Carthami (Classification system: Carthamus tinctorius L.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami belong to
Plant, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, and flower pesticide yellow is unified into pipe, exceeds and split
Outside sheet, its central authorities have stigma to expose.Have special fragrance, mildly bitter flavor.To spend, length of a film, color be scarlet, the soft person of matter is preferred.Invigorate blood circulation logical
Warp, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the breast side of body twinge, traumatic injury, skin ulcer
Infections swells and ache curative effect.Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.
Radix Notoginseng is to be used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has " gold
Do not change ", the good reputation of " southern part of the country SHENCAO ".Because season in Chang Chun winter two excavates, it is divided into again " spring seven " and " winter seven ".Qing Dynasty's pharmaceutical texts
Described in supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying first, Radix Notoginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for
Most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", i.e. with Radix Notoginseng for primary raw material system
Become.Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame
Notopterygium incisum. Umbelliferae, Notopterygium plant, Chinese medicine cures mainly: warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, head
The most lossless, cold-damp numbness, upper limb rheumatalgia.Dissipate exterior cold;Wind-damp dispelling;Profit joint;Pain relieving.Main affection of exogenous wind-cold;Have a headache lossless;Edema due to wind pathogen
Edema;Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea;External curing vitiligo,
Alopecia areata.Relieving exterior syndrome and dispelling cold, expelling wind and dampness, pain relieving.Property of medicine opinion ": " controlling harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, actinal surface is askew more
Heresy, insensitive impediment all over." " Japan hanako materia medica ": " controls a wind cutting gas, muscles and bones fist contraction, and extremity are thin bad, the head rotation red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times
Aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs.″
Rhizoma Chuanxiong, formal name used at school: Ligusticum chuanxiong hort, cultivated plant, main product is in Sichuan (Guanxian county), at cloud
The ground such as south, Guizhou, Guangxi, are grown on the climatic environment of gentleness.It is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping,
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keeps, can go scattered, up up to top, mountain peak;Enter again blood system, descending up to the sea of blood.Blood circulation promoting and blood stasis dispelling is made
With extensively, the various disease of suitable stagnation of blood stasis;Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.Former times people
Meaning Rhizoma Chuanxiong is the gas medicine in blood, the function such as its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving.
Caulis Spatholobi, for the another name of the various plants such as Schisandraceae, Sargentodoxaceae, Cuscutaceae, Papilionaceae.8~JIUYUE adopt
Receive, be distributed in China East China, South China and the ground such as Hubei, Yunnan.Caulis Spatholobi bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney channel, color
Red enter blood, matter profit row dissipate;There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation;Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, the moon
Through uncomfortable, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.Treat the waist gonalgia caused by rheumatism, rheumatic arthralgia, limb
Body is numb, often and the compatibility such as Flos Carthami Radix Angelicae Pubescentis, Radix Paeoniae Rubra, Pheretima, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.Can be used for menoxenia, amenorrhea, dysmenorrhea,
Often use together with Rhizoma Cyperi, Herba Leonuri.
Radix Dipsaci, has another name called Radix Dipsaci, also name Radix Dipsaci, Chinese medicine name.For the root of herbaceos perennial Radix Dipsaci, because of energy, " continuous folding connects
Bone " and gain the name.Autumn excavates, and removes root head and fibrous root, is dried to low baking temperature half-dried, when bank up " diaphoresis " is to internal virescence, then
Dry." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians are determined in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, antiabortive, is suitable for controlling married woman leucorrhea,
Tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”
Herba speranskiae tuberculatae, (formal name used at school: Phryma leptostachya L.subsp.asiatica (Hara) Kitamura) is used as medicine
Part is plant herb.Green, dry with herb color, matter is tender, free from admixture person is preferred.It is distributed in all parts of the country.It mostly is artificial plantation.
Reddish brown with stem color, without leaf, be dried, free from admixture person is preferred.Annual herb flowers, produce the nations of China and India.Property happiness sunlight, be afraid of
Wet, heat-resisting can not resist cold, suitable be born in loose fertile micro-sour soil earth, but the most barren-resistant.Adaptability is relatively strong, transplants and easily survives, growth
Rapidly.Seed also name Semen Impatientis, stem also name Herba speranskiae tuberculatae, all can be used as medicine, have blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow.
External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.
Radix Clematidis belongs to medicinal plants, and medical material Ji Yuan source is more, " Kaibao Bencao ", " Bencao Tujing ", herbal for Relief of Famines
Etc. contained Radix Clematidis, for goatweed;The Radix Clematidis that " the southern regions of the Yunnan Province book on Chinese herbal medicine " is contained, is feverfew, and uses many now
For " China's book on Chinese herbal medicine " contained cohosh Radix Clematidis, Clematis hexapetala, northeast clematis.Domestic distributed more widely, its root and stem
It is used as medicine and there is wind-damp dispelling, the meridian dredging, the effect of the bone stalk that disappears.In modern clinic is put into practice, its new purposes is constantly found, as
Treatment cholelithiasis, calcanean spur, talalgia, the esophageal carcinoma etc..Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, dissipate the hypochondriac lump.Cure mainly gout
Insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, muscle arteries and veins contracture, joint stuffiness, tinea pedis, malaria, lump in the abdomen, tetanus, flat
Fructus Persicae body is scorching, and all a fishbone or other bone caught in the throat swallow.Tang Materia Medica: waist, kidney, foot knee joint, accumulation, all cold diseases of enteral, is not recovered, the effect of clothes." Kai Baoben
Grass ": main all wind, logical five Tibetan of a surname, cold stagnant in removing abdomen, septum cordis expectorant water amasss for a long time, and lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, waist knee joint is cold
Pain and treatment injured.
Radix Saposhnikoviae, Chinese medicine name.Another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds.It is the name of a kind of medicinal herbs, perennial herb
Plant, its nice and cool weather of happiness, cold-resistant, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, the ground such as Inner Mongol.The Gen Kesheng of Radix Saposhnikoviae
With.Acrid in the mouth, sweet, slightly warm in nature.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.
Radix Stephaniae Tetrandrae, Chinese medicine name.Dry mature fruit for samphire Fructus Foeniculi Foeniculum vuLgare Mill..Autumn
Ji Guoshi taps plant time the ripest, dries, and lays fruit, removes impurity.Acrid in the mouth, warm in nature.Return liver,kidney,spleen, stomach warp.Anti-existing
Dispersing cold for relieving pain, effect of regulating qi-flowing for harmonizing stomach.Effect of existing warming the kidney dispersing cold for relieving pain prevented by salt.The anti-colic of cold type stomachache that has been used for, the testis swelling and hanging down of either of the testes,
Dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting.The anti-colic of cold type stomachache that has been used for of salt, the testis swelling and hanging down of either of the testes, through cold stomachache.
Olibanum, Chinese medicine name.For olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener
The resin that Boswellia bhaurdajiana Birdw. bark oozes out.It is divided into Somalia's Olibanum and Gum Olibanum Ethiopia, often
Planting Olibanum man's cap used in ancient times again is Olibanum pearl and former Olibanum.Blood-activating and qi-promoting pain relieving, detumescence and promoting granulation.Cure mainly for obstruction of qi in the chest and cardialgia, gastralgia, bitterly
Through amenorrhea, postpartum stagnation, lump in the abdomen stomachache, rheumatic arthralgia, muscle arteries and veins contracture, traumatic injury, carbuncle skin infection.
Myrrha, Chinese medicine name.For olive subject plant Herba Violae tree Commiphora myrrha Engl. or Ha Didingshu
The dry resin of Commiphora molmol Engl..It is divided into natural Myrrha and gum opoponax.It is distributed in Somalia, Ethiopia Russia
Than Asia and south, the Arabia Peninsula and other places.There is dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation.It is usually used in obstruction of qi in the chest and cardialgia, gastralgia,
Dysmenorrhea amenorrhea, postpartum stagnation, abdominal mass stomachache, rheumatic arthralgia, traumatic injury, the treatment of the diseases such as carbuncle skin infection.
Radix Stephaniae Tetrandrae inducing diuresis to remove edema;Wind-expelling pain-stopping.Main edema;Dysuria;Rheumatic arthralgia;Tinea pedis swells and ache;Scabies skin ulcer swells;High blood
Pressure is sick.Bitter in the mouth;Pungent;Cold in nature;Return bladder;Lung;Spleen channel." herbal classic ": main air is trembled with fear pyrexial malaria, all epilepsys of steam, evil removing, profit defecation.
" not Lu ": treat edema, swelling due to wind, go bladder heat, typhoid fever cold and heat pathogen, apoplexy hands muscle spasm of the leg and foot, stopping leak, dissipate carbuncle dislike tie, (controlling) all
Copperworm skin ulcer, logical space between skin and muscles, profit nine orifices.
Spina Gleditsiae, Chinese medicine name.Dry Spina jujubae for leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Have and disappear
Swollen poison holding, evacuation of pus, effect of parasite killing.Be usually used in carbuncle from the beginning of or difficulty in discharging of pus;External treatment scabies leprosy.Elementary Medicine ": " Spina Gleditsiae,
All carbuncle persons of not breaking, can have one's ideas straightened out;Do not break person and can reach skin ulcer institute by priming, be all malignant boil tinea and leprosy key medicine also." Compendium of Material Medica: " soap
Pod thorn controls wind parasite killing, and merit is same with pod, the different ear but its sharp keen through disease is done.”
Herba Lycopodii is the herb of Lycopodiaceae Lycopodium plant Lycopodium clavatum Lycopodium japonicum Thunb..Control joint
Bitterly: Radix et Rhizoma Smilacis Ripariae five money, roadside chaste tree one or two, Radix Ilicis Pernyi one or two, Herba Siegesbeckiae five money.It is decocted in water for oral dose.(" Hunan medicine will ") meridian distribution of property and flavor:
Toil temperature, enters Liver Channel.Attending effectiveness: expelling wind and cold. dehumidifying detumescence, relaxing muscles and tendons and activating QI and blood in the collateral.For anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle.
External is controlled osteopatia sprain and is swollen and ache.
Cortex cinnamomi japonici (Ramulus Cinnamomi), because of the fragrant aroma containing volatile oil, can make meat dish raw meat solution of dispelling greasy, and fragrance is good to eat, and then makes us appetite
Increase.In diet, add Cortex cinnamomi japonici (Ramulus Cinnamomi) in right amount, potentially contribute to prevention or delay the type Ⅱdiabetes mellitus caused with age.According to
Britain " New Scientist " magazine ran: Cortex cinnamomi japonici (Ramulus Cinnamomi) can reactivate the adipose cell respond to insulin, greatly speeds up Portugal
The metabolism of grape sugar.Every day adds 1/4 to 1 spoon of Cortex cinnamomi japonici powder in beverage or spoon meat, may play type ii diabetes
Preventive effect.Cortex cinnamomi japonici (Ramulus Cinnamomi) contains compounds derived from phenyl acrylic acid, has therapeutical effect to prostatic hyperplasia, and can increase prostata tissue
Blood flow, promotes the improvement of local organization blood fortune.Cortex cinnamomi japonici (Ramulus Cinnamomi) is the tree in canella Cinnamomum japonica, cloudy fragrant, cinnamomum chingii Metcalf or osmanthus, river etc.
Skin, gathers the most in the winter time, can be used as medicine after drying in the shade.Cortex cinnamomi japonici (Ramulus Cinnamomi) also has medicinal efficacy, the traditional Chinese medical science to think simultaneously, Cortex cinnamomi japonici (Ramulus Cinnamomi) heat,
Sweet in the mouth is pungent, gas is fragrant, nontoxic, there is dim stomach cold relieving relaxing muscles and tendons to promote blood circulation, coronary circulation-promoting pain-relieving and the function of antidiarrheal.Cure mainly the cold fullness in the chest of abdomen, vomit
Tell dysphagic, rheumatic arthralgia, fall the diseases such as damage stagnant, the dysentery hemorrhoidal hamorrhage of the stasis of blood.Supplement to the Herbal: all cold in controlling abdomen, vim and vigour distending pain." sea medicine
Book on Chinese herbal medicine ": mending warm waist foot, stagnant blood after bankruptcy, control dysentery hemorrhoidal hamorrhage, power is same with Cortex Cinnamomi." Traditional Chinese Medicine in Sichuan will ": liver and kidney tonifying, qualcomm meridian,
Dispersing wind and cold, dehumidify numbness, warm waist knee joint, anti-nausea.Controlling bones and muscles pain, diarrhea due to cold pathogen is suffered from abdominal pain, and cholera is vomitted, dysphagic fullness in the chest, bladder colic of cold type, waist
Knee joint is existing the coldest, rheumatic arthralgia and fall the diseases such as the damage stasis of blood is stagnant.
Caulis Sargentodoxae, another name: Caulis Sargentodoxae, Classification system: Sargentodoxa cuneata. be Lardizabalaceae, Saggentodoxa fallen leaves,
Bejuco;Rhizome is pharmaceutically acceptable, has dredge the meridian passage, eliminating stasis to stop pain, effect such as promoting the circulation of blood, parasite killing of regulating the flow of vital energy, cures mainly rheumatalgia, sky
The gas joint acid that causes of change is swollen, traumatic injury, dysmenorrhea, amenorrhea, ascarid.Also veterinary medicament can be made, to oxen and horses food supply retail shop ant by mistake
Locust associated diseases is effective in cure.
Eupolyphaga Seu Steleophaga, Chinese medicine name.For Corydiidae insecticide eupolyphoge sinensis Eupolyph, aga sin, ensis Walker or Ji eupolyphoge sinensis
The female worm dry body of Steleophaga Plancyi (Boleny).There is removing blood stasis, effect of reunion of fractured tendons and bones.For traumatic injury
Damage, injury of tendon and muscle fracture, blood stasis amenorrhea, postpartum stagnation stomachache, addiction abdominal mass mass in the abdomen.
Fructus Zanthoxyli is pungent, numb, temperature.Return spleen, stomach, kidney channel.Effect green pepper is red: warming middle-JIAO to relieve pain, killing parasites for relieving itching.Cure mainly for gastral cavity abdomen cold
Bitterly, vomiting is had loose bowels, abdominal pain due to worm stagnation;External treatment eczema, pudendal pruritus.
Specific embodiment 1
Radix Notoginseng 1000g, Radix Angelicae Dahuricae 1000g, Myrrha 1000g, Olibanum 1000g and the Rhizoma Et Radix Notopterygii 1000g way of distillation are vaporized into knot
Crystalline substance, pulverizes stand-by, for component 1;Other raw materials Flos Carthami 1000g, Spina Gleditsiae 1000g, Rhizoma Drynariae 1000g, Cortex Eucommiae 1000g, Rhizoma Corydalis
Rope 1000g, Caulis Spatholobi 1000g, Herba Lycopodii 1000g, Radix Clematidis 1000g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 1000g, Radix Dipsaci 1000g, Radix Stephaniae Tetrandrae 1000g, river
Rhizome of chuanxiong 1000g, Herba speranskiae tuberculatae 1000g, Pheretima 1000g, Eupolyphaga Seu Steleophaga 1000g, Radix Saposhnikoviae 1000g, Cortex Acanthopancis 1000g, Radix Angelicae Pubescentis 1000g are red
Rattan 1000g, Fructus Zanthoxyli 1000g, by soak with ethanol, heated and boiled 3 times, each 1-2 hour, filter, and filtrate is standby;By after merging 3
In secondary filtrate suction concentrating under reduced pressure tank, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C;Become
Component 2, blending ingredients 1 and component 2, mediation substrate, make granule.
Specific embodiment 2
According to described number by raw material Flos Carthami 1200g, Spina Gleditsiae 1300g, Rhizoma Drynariae 1300g, Cortex Eucommiae 1300g, Rhizoma Corydalis
1200g, Caulis Spatholobi 1300g, Herba Lycopodii 1300g, Radix Clematidis 1300g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 1300g, Radix Dipsaci 1300g, Radix Stephaniae Tetrandrae 1200g, Rhizoma Chuanxiong
1100g, Herba speranskiae tuberculatae 1200g, Pheretima 1300g, Eupolyphaga Seu Steleophaga 1300g, Radix Saposhnikoviae 1100g, Cortex Acanthopancis 1200g, Radix Angelicae Pubescentis 1100g, Caulis Sargentodoxae
1200g, Fructus Zanthoxyli 1100g, add in the Oleum Sesami of 5-10 times of weight portion and soak 7-10 days;The heating of soaked for Oleum Sesami crude drug is carried
Taking, big fire is boiled, and after Oleum Sesami boiling, firepower reduces, endure to crude drug appearance be dark brown, internal coke yellow, pull medicinal residues out, will
Medicine oil continues to temper, and is stirred continuously, and refining is to beading of dripping.By Radix Notoginseng 1200g, Radix Angelicae Dahuricae 1200g, Myrrha 1200g, Olibanum
1200g and the Rhizoma Et Radix Notopterygii 1200g way of distillation are distilled into crystallization, and are ground into mistake 200-300 mesh sieve after fine powder.The crystallization fine powder that will sieve
Putting in the medicine oil tempered, paste making agent is poured in cold water the most afterwards, soaks 5-10 days, changes water every day once, releasing fire-toxin, pelletizes.
Specific embodiment 3
Radix Notoginseng 1200g, Radix Angelicae Dahuricae 1200g, Myrrha 1100g, Olibanum 1200g and the Rhizoma Et Radix Notopterygii 1200g way of distillation are vaporized into knot
Crystalline substance, pulverizes stand-by, for component 1;Other raw materials Flos Carthami 1200g, Spina Gleditsiae 1300g, Rhizoma Drynariae 1300g, Cortex Eucommiae 1300g, Rhizoma Corydalis
Rope 1200g, Caulis Spatholobi 1300g, Herba Lycopodii 1300g, Radix Clematidis 1300g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 1300g, Radix Dipsaci 1300g, Radix Stephaniae Tetrandrae 1200g, river
Rhizome of chuanxiong 1100g, Herba speranskiae tuberculatae 1200g, Pheretima 1300g, Eupolyphaga Seu Steleophaga 1300g, Radix Saposhnikoviae 1100g, Cortex Acanthopancis 1200g, Radix Angelicae Pubescentis 1100g are red
Rattan 1200g, Fructus Zanthoxyli 1100g, soaked and be placed in lid stainless steel cask, adds 70% ethanol, and quality is coarse grained 0.8-1
Times, stir, moistening airtight placement more than 1 hour, make fully to expand;Filter plate gauze bag parcel bottom percolator is paved
After the drug sample after moistening expansion mixed pine again do to dissipate, then contain powder with rustless steel spoon, load percolator uniformly, fill 10-
12 cm thicks, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably pressurize, medicated powder loads must not exceed and oozes
Filter 2/3 eminence of cylinder;Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then
It is slowly added into 70% ethanol;Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve,
Cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material stream per minute
Going out 2~3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container;Percolate is merged and stands, stand
Standby;The filtrate of filtration being inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0
~5 DEG C of deepfreezes 24 hours;The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted economic benefits and social benefits again and is concentrated in vacuo
In device, it is concentrated into every 1ml crude drug amount Han 0.1g, for component 2.By component 1 and the merging of component 2, it is in harmonious proportion and pelletizes, pack.
External used medicine of the present invention repeatedly Skin Irritation Test result
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", to this
Invention medicine has carried out repeatedly Skin Irritation Test.
Tested material: the preparation of the present invention.Weigh tested material 50g to add distilled water to make 50% pastel standby.
Laboratory animal: provided Japan's white big ear rabbit 4 by Shandong University medical college Experimental Animal Center, male and female half and half,
Body weight 2.5-3.0kg, primary animal (the dynamic word the 08-018th of doctor), feed resource is ibid.Animal housing's environment: temperature: 22-25
DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: test first 24 hours, in often
Rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Only take tested material 0.5g/, after preparation, be coated in every rabbit one
On the skin of side, smearing every day once, offside all makees solvent control.Smear 14d continuously.Every day be coated with before cropping, must not injured skin,
Ensure that tested material is fully contacted with skin.Observe dermoreaction and marking every day.Off-test, takes and smears area skin and carry out disease
Reason histological examination.
Experimental result: repeatedly Skin Irritation Test shows the present invention the highest stimulation index of repeatedly skin irritation and pathological tissue
Integration is 0, according to skin irritation in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection "
Strength grading standard, the present invention repeatedly skin irritation intensity belongs to nonirritant.
Skin anaphylactic test
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", to this
Invention medicine has carried out skin anaphylactic test.
Tested material: external preparation of the present invention.Weigh tested material 10g to add distilled water to make 50% pastel standby.Positive right
According to thing: 2,4-dinitro-chloro-benzenes, produce in Xing Jin chemical plant, Beijing, lot number 20020522.Laboratory animal: cured by Shandong University
Institute's Experimental Animal Center provides Cavia porcellus 30, and male and female half and half, body weight 250-300g, primary animal, feed resource is ibid.Animal
Room environmental: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method:
Test Cavia porcellus is randomly divided into three groups, often group 10, male and female half and half, respectively tested material group, negative control group and positive control
Group.
Sensitization contact: guinea pig back left of spine hair was removed in first 24 hours to tested material, unhairing scope about 3cm × 3cm.
Only take tested material 0.2g/, be coated in depilation district on the left of back part of animal after preparation, continue 6 hours.7th day and fortnight, use
Same method is repeated once, and positive controls is coated with 1%DNCB, and negative control group does not deals with.Excite contact: in last to tested
Fortnight after thing, by tested material 0.2g/ only, is coated on depilation district on the right side of guinea pig back, removes tested material after 6 hours after preparation,
At once observe anaphylaxis situation, then again observed in 1,24,48,72 hours.Positive controls is coated with 1%DNCB, negative right
Do not deal with according to group.Observational technique is with tested material group.
Result of the test: skin anaphylactic test shows external preparation of the present invention, according to " for health care according to DB61-267-1998
Product Toxicological evaluation program and the method for inspection " in relevant sensitization of skin intensity evaluation standard, the invention belongs to without sensitization.
Pharmacological experiment
One, microcirculation experimental technique:
1. materials and methods: take 50 Kunming mouses, Shandong University's biology laboratory provides.It is randomly divided into 5 groups, often group
10 (male and female half and half), it is a little that matched group every Mus auris dextra is coated with normal saline;Positive controls every Mus auris dextra gives triamcinolone acetonide note
Penetrating agent 20mg, treatment group invention formulation (preparing by embodiment institute method 3) solubilizer hybrid injection, test component is this
Dosage group in bright low dose group 400mg/kg/h, the present inventionHigh dose 800mg/kg/h of the present invention.15min
Pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, subsequently tail vein injection 0.1% epinephrine 0.1mL/
10g, observes mouse right ear fine motion vein bore (μm) and 0.2mm immediately2Blood capillary net number .t inspection processes experimental data.
2 results and discussion
2.1. on microcirculatory impact
Compared with matched group, tested group 1 has showed increased (P < 0.01) to mice capillary open number;Tested group 2 right
Venule bore and capillary open number dramatically increase (P < 0.01);Tested group 3 to mice fine motion, vein bore and hair
Thin vessel open number all has increase (P < 0.01);Illustrate to be improved microcirculation by reagent, have function of promoting blood circulation to disperse blood clots (table 1).
Table 1, the present invention are on mice fine motion, vein bore and the impact of capillary open number
Two, external preparation xylol of the present invention causes the impact of mice auricle swelling
Male ICR mouse 60, is randomly divided into model control group, positive controls by body weight, high, medium and low dose of the present invention
Amount group, totally 5 groups, often group 12.Senior middle school low dose group rat smear respectively this product 350,250,125mg/kg, positive controls is coated with
Smearing ZHENGHONGHUA YOU 125mg/kg, model group gives equal-volume normal saline, and the biggest 1 time, continuous 7 days, last was administered latter 1 hour,
50 μ l dimethylbenzene are applied to two sides before and after every mouse right ear.After 4 hours, de-neck is put to death, and cuts ears, stainless with a diameter of 8mm
Steel drift sweeps away left and right auricle, weighs, using the difference of two auricle weight as weighing the index of swelling degree, antiinflammatory action intensity with
Suppression ratio (%) represents, carries out statistical analysis with SPSS11.5 software kit.The results are shown in Table 2.
The table 2 impact (x ± s) on mice ear
Compare with model control group: ** p < 0.01, * * * p < 0.001
Test result indicate that, this product xylol causes mice auricle swelling obvious inhibiting effect, its high dose group and mould
Type group compares pole significant difference.
Three. the impact of rat paw edema caused by Carrageenan
Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, ZHENGHONGHUA YOU positive controls, basis
Invention spray group.Often group 10, male and female half and half, sub-cage rearing.Positive controls and drug component of the present invention are smeared other every day
0.2g, blank group gives the normal saline of same dosage and smears, successive administration 7 days, is administered latter 30 minutes in last, exists respectively
Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ only causes inflammation, respectively at cause scorching before and cause inflammation after 15,30,
60, the girth surveying the Rat Right metapedes sole of the foot in 120,240 minutes, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching
Front foot sole of the foot girth)/cause scorching front foot sole of the foot girth × 100%];The results are shown in Table 3.
The impact (X ± SD) of rat paw edema caused by table 3 Carrageenan
Note: compare with matched group: * * P < 0.01;Compare with positive controls: #P < 0.05;Can by upper table experimental result
To find out, medicine group of the present invention has the pharmacological action of blood stasis dispelling of preferably subsiding a swelling.
Talalgia is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia
Also known as calcanean spur or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains, outward with old deficiency of the kidney
Hinder with to experience cold-damp relevant.Doctor trained in Western medicine typically solves this problem with operation, though there being certain curative effect, but plants destructive operation, will be with
Bone posterior tibial nerve props up and props up cut-out with sural nerve, has side effect in various degree or causes some complication;Chinese medicine product is then
Because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys favor.Medicine of the present invention is made
For local, permeate skin, through sick institute, promote qi and blood circulation, improve local blood and run, soften bony spur, promote that inflammation is inhaled
Receive, so that remission or elimination.Oral administration and externally of the present invention, can effectively expand peripheral vessel, improves foot's microcirculation, detumescence
Blood stasis dispelling, activating collaterals to relieve pain effect is obvious.
Clinical research
All patients are selected from the court's outpatient service in May, 2013 in May, 2012 to talalgia patient 120 example, the maleest 45 examples,
Female 75 example, age 46~78 years old, average 55 years old, biped person 80 example, monopodia 43 example, meter 223 foot.Patient medical history January to 2 years, flat
All half a year.All deficiency of the liver and kidneys: the other network of Liver and kidney and branch thereof is walked around heel, liver governing tendons, main store blood, and kidney governing bones, main store essential substances,
The raw marrow of essence.Old body, deficiency of the liver and kindey, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless foster, and bone is become homeless master, and bone withers flaccidity of tendon and muscle, therefore station
During vertical or walking heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.With heel pain, increase the weight of when standing and walk, stop
Alleviate after breath as feature.The x line sheet prompting of position, calcaneus side, heel bone hyperosteogeny 80 example, normal 48 examples of x line sheet, all meet 1997 editions
" traditional Chinese medical science injury of tendon and muscle " diagnostic criteria.
Therapeutic Method
Chinese medicine fumigation and washing uses the active side of washing of lower limb of the present invention, side's medicine to form: Flos Carthami 15g, Spina Gleditsiae 13g, Rhizoma Drynariae 14g,
Cortex Eucommiae 13g, Rhizoma Corydalis 11g, Caulis Spatholobi 13g, Herba Lycopodii 13g, Radix Clematidis 13g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 14g, Radix Dipsaci 15g, Radix Angelicae Dahuricae 15g, Radix Stephaniae Tetrandrae
12g, Rhizoma Chuanxiong 14g, Herba speranskiae tuberculatae 13g, Radix Notoginseng 13g, Myrrha 13g, Olibanum 14g, Rhizoma Et Radix Notopterygii 13g, Pheretima 14g, Eupolyphaga Seu Steleophaga 13g, Radix Saposhnikoviae
13g, Cortex Acanthopancis 12g, Radix Angelicae Pubescentis 14g, Caulis Sargentodoxae 13g, Fructus Zanthoxyli 12g.Granule is made by embodiment.Medicine-feeding adds water, and to soak 1 little for 2000mL
Time, after being fried boiling, 30min decocted again by little fire, and fumigation and wash method is suffered from sufficient while hot, each 30-50min, every day each 1 time sooner or later, every dose of medicinal 3d, and 4
Agent is 1 course for the treatment of.Criterion of therapeutical effect drafts following curative effect mark with reference to State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect "
Accurate.Curing: heel pain disappears, walking is normal;Taking a turn for the better: heel pain alleviates, walking takes a turn for the better;Invalid: heel pain is without improving.
Efficacy result
This is organized 120 examples 223 foot patients and all obtains and follow up a case by regular visits to, follow up time January.Through 1 course of therapy, wherein cure 159
Foot, patient's cure rate 77.9%;Patient takes a turn for the better 39 enough;Improvement rate 18.98%, invalid 11 foots;Patient's inefficiency 5.27%;Effectively
Rate 96.32%.
Discuss
Talalgia is one of common ailment of middle-aged and old, usually heel portion pain, difficulty in walking, and row occurs without obvious inducement
Walk and substantially increase the weight of for its feature, to have a strong impact on the life of middle-aged and elderly people after bearing a heavy burden.Talalgia name of disease is to order with heel portion pain
The disease of name.Heel portion is the major part that human body bears a heavy burden, and has following anatomical features: heel skin is portion the thickest in human body
Position, its subcutaneous fat is fine and close and flourishing, also known as fat pad.With the presence of synovial bursa between fat and calcaneus.Sole of the foot fascia and toe are short in the wrong
Flesh is attached to calcaneal tuberosity front, and heel string is attached to the back upper place of calcaneal tuberosity in the form of sheets.
With advancing age, organism quality declines middle-aged and elderly people, and heel tissue strains through long-term chronic, fat pad etc.
Tissue dewatering, atrophy, regression;Elastic reduce, simultaneously year the age increase skeleton decalcification gradually occur, plantar aponeurosis, heel string etc. is inadaptable
Tense situation during walking, often damages the most slight courage and uprightness at calcaneus attachment and oozes because being not suitable with tractive for a long time
Go out, be with the passing of time excited into ostosis hyperosteogeny and produce bony spur.In addition synovial membrane repeatedly rubs and also may result in the thorn such as synovial bursae inflammation
There is pain in sharp sensory nerve.The traditional Chinese medical science thinks that middle-aged and elderly people kidney qi is gradually lost, and bone withers flaccidity of tendon and muscle, and QI and blood can not be moistened in foot, and exopathogen is taken advantage of
Machine numbness hinders passages through which vital energy circulates and causes pain.Surely belong to " arthromyodynia " category.Doctor trained in Western medicine typically solves this problem with operation, though there being certain curative effect, but
Plant destructive operation, calcaneus posterior tibial nerve is propped up and props up cut-out with sural nerve, have side effect in various degree or cause some also
Send out disease;Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys
Favor.Medicine of the present invention acts on local, permeates skin, through sick institute, promotes qi and blood circulation, improve local blood and run, soft
Change bony spur, promote that inflammation absorbs, so that remission or elimination.Oral administration and externally of the present invention, can effectively expand peripheral vessel, change
Kind foot microcirculation, blood stasis dispelling of subsiding a swelling, activating collaterals to relieve pain effect is obvious.
Typical case
Model, man, 65 years old, first visit in November, 2014.The left talalgia of patient 2 over, during walking its pain the most unbearably, suffer from foot can not
Stand.Personal YUNNAN BAIYAO cream, GUZHIZENGSHENG YITIELING external application, ibuprofen for oral administration 1 week, symptom is without improving.Examine and see left talalgia,
Tenderness and kowtow pain substantially, lumbosacral aching pain, tinnitus, red tongue, tongue limit has tooth to print, white and thin fur, thready and moderate pulse.X-ray film shows left calcaneus bone
Superfluous.Patient fifty, and QI-blood circulation is slow, feels cold-evil again, cold main stagnates, main spasm, cause meridians to be hindered, coagulation of QI-blood obstructed and
Bitterly, pain with tenderness, happiness heat is afraid of cool.Control when the kidney invigorating cold expelling, dissipating blood stasis dredging collateral.External application Chinese medicine fumigation and wash method side fumigation and wash method.Fang Yong: Flos Carthami 15g, soap
Fructus Gleditsia acupuncture 13g, Rhizoma Drynariae 14g, Cortex Eucommiae 13g, Rhizoma Corydalis 11g, Caulis Spatholobi 13g, Herba Lycopodii 13g, Radix Clematidis 13g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 14g, river
Disconnected 15g, Radix Angelicae Dahuricae 15g, Radix Stephaniae Tetrandrae 12g, Rhizoma Chuanxiong 14g, Herba speranskiae tuberculatae 13g, Radix Notoginseng 13g, Myrrha 13g, Olibanum 14g, Rhizoma Et Radix Notopterygii 13g, Pheretima
14g, Eupolyphaga Seu Steleophaga 13g, Radix Saposhnikoviae 13g, Cortex Acanthopancis 12g, Radix Angelicae Pubescentis 14g, Caulis Sargentodoxae 13g, Fructus Zanthoxyli 12g.Prepare by embodiment 3 method.On
The medicine 2000mL that adds water soaks 1 hour, and after being fried boiling, 30min decocted again by little fire, and fumigation and wash method suffers from foot, each 30-50min while hot, and every day is sooner or later
Each 1 time, every dose of medicinal 3d, 4 doses is 1 course for the treatment of.
December further consultation: left heel pain subtracts greatly, tenderness and percussion pain disappear, hypodynia during walking.Continue and use Chinese medicine fumigation and washing therapy,
Left talalgia disappears, can walking with load.Follow up a case by regular visits to 6a, have no recurrence.
Claims (10)
1. the Chinese medicine fumigation and washing soaking agent treating talalgia, it is characterised in that described Chinese medicine fumigation and washing soaking agent includes following heavy
The crude drug of amount number: Flos Carthami 10~20 parts, Spina Gleditsiae 10~20 parts, Rhizoma Drynariae 10~20 parts, the Cortex Eucommiae 10~20 parts, Rhizoma Corydalis
10~20 parts, Caulis Spatholobi 10~20 parts, Herba Lycopodii 10~20 parts, Radix Clematidis 10~20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~20 parts, Radix Dipsaci 10~20
Part, the Radix Angelicae Dahuricae 10~20 parts, Radix Stephaniae Tetrandrae 10~20 parts, Rhizoma Chuanxiong 10~20 parts, Herba speranskiae tuberculatae 10~20 parts, Radix Notoginseng 10~20 parts, Myrrha 10
~20 parts, Olibanum 10~20 parts, Rhizoma Et Radix Notopterygii 10~20 parts, Pheretima 10~20 parts, Eupolyphaga Seu Steleophaga 10~20 parts, Radix Saposhnikoviae 10~20 parts, five
Cortex Acanthopanacis Radicis 10~20 parts, Radix Angelicae Pubescentis 10~20 parts, Caulis Sargentodoxae 10~20 parts, Fructus Zanthoxyli 10~20 parts.
Treat the Chinese medicine fumigation and washing soaking agent of talalgia the most according to claim 1, it is characterised in that described Chinese medicine fumigation and washing soaks
Agent also includes the crude drug of following parts by weight: Flos Carthami 10~15 parts, Spina Gleditsiae 10~15 parts, Rhizoma Drynariae 10~15 parts, the Cortex Eucommiae
10~15 parts, Rhizoma Corydalis 10~15 parts, Caulis Spatholobi 10~15 parts, Herba Lycopodii 10~15 parts, Radix Clematidis 10~15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~
15 parts, Radix Dipsaci 10~15 parts, the Radix Angelicae Dahuricae 10~15 parts, Radix Stephaniae Tetrandrae 10~15 parts, Rhizoma Chuanxiong 10~20 parts, Herba speranskiae tuberculatae 10~20 parts, Radix Notoginseng
10~20 parts, Myrrha 10~20 parts, Olibanum 10~20 parts, Rhizoma Et Radix Notopterygii 10~20 parts, Pheretima 10~20 parts, Eupolyphaga Seu Steleophaga 10~20 parts,
Radix Saposhnikoviae 10~20 parts, Cortex Acanthopancis 10~20 parts, Radix Angelicae Pubescentis 10~20 parts, Caulis Sargentodoxae 10~20 parts, Fructus Zanthoxyli 10~20 parts.
Treat the Chinese medicine fumigation and washing soaking agent of talalgia the most according to claim 1, it is characterised in that described Chinese medicine fumigation and washing soaks
Agent also includes the crude drug of following parts by weight: Flos Carthami 10~20 parts, Spina Gleditsiae 10~20 parts, Rhizoma Drynariae 10~20 parts, the Cortex Eucommiae
10~20 parts, Rhizoma Corydalis 10~20 parts, Caulis Spatholobi 10~20 parts, Herba Lycopodii 10~20 parts, Radix Clematidis 10~20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10~
20 parts, Radix Dipsaci 10~20 parts, the Radix Angelicae Dahuricae 10~20 parts, Radix Stephaniae Tetrandrae 10~20 parts, Rhizoma Chuanxiong 10~15 parts, Herba speranskiae tuberculatae 10~15 parts, Radix Notoginseng
10~15 parts, Myrrha 10~15 parts, Olibanum 10~15 parts, Rhizoma Et Radix Notopterygii 10~15 parts, Pheretima 10~15 parts, Eupolyphaga Seu Steleophaga 10~15 parts,
Radix Saposhnikoviae 10~15 parts, Cortex Acanthopancis 10~15 parts, Radix Angelicae Pubescentis 10~15 parts, Caulis Sargentodoxae 10~15 parts, Fructus Zanthoxyli 10~15 parts.
4. treating a preparation method for the Chinese medicine fumigation and washing soaking agent of talalgia as according to any one of claims 1 to 3, it is special
Levying and be, the preparation method of described Chinese medicine fumigation and washing soaking agent comprises the following steps:
A. take Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and the Rhizoma Et Radix Notopterygii way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1.
B. the extraction of surplus stock medicinal alcohol is taken, as component 2;
C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 3;
D. by 2-in-1 for component 1 component and be condensed into extractum, add component 1 and stir and make granule, subpackage;Rush with boiled water during use
Bubble.
Treat the preparation method of the Chinese medicine fumigation and washing soaking agent of talalgia the most according to claim 4, it is characterised in that described step
In rapid a, first crude drug Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and Rhizoma Et Radix Notopterygii steam method is distilled, obtains crystal, then pulverize,
Cross 100-120 mesh sieve, standby as component 1.
Treat the preparation method of the Chinese medicine fumigation and washing soaking agent of talalgia the most according to claim 4, it is characterised in that described step
In rapid b, being shredded by remaining crude drug, soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained
0.8-1 times, stir, moistening airtight placement more than 1 hour, make fully to expand;By the gauze bag bag of filter plate bottom percolator
Wrap up in again the drug sample after moistening expansion is mixed after paving pine do dissipate, then with rustless steel spoon contain powder, load percolator uniformly,
Dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurize, medicated powder must not load and surpassed
Cross 2/3 eminence of percolator;Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container,
Then 70% ethanol it is slowly added into;Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, closedown is put
Material valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation speed and is generally 1000g medical material every point
Clock flows out 2~3ml, and filtrate puts into liquid container, and pours ethanol during emptying into liquid container;Percolate is merged and stands,
Stand for standby use, as component 2.
Treat the preparation method of the Chinese medicine fumigation and washing soaking agent of talalgia the most according to claim 4, it is characterised in that described step
In rapid c, putting in 10 times amount water by above-mentioned stripped raw material residue, soak 1-2 hour, heating extraction 2 times, each 1-2 is little
Time, removing supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming,
The filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 3.
Treat the preparation method of the Chinese medicine fumigation and washing soaking agent of talalgia the most according to claim 4, it is characterised in that described step
In rapid d, component 2 is merged with component 3, put in economic benefits and social benefits vacuum concentrator and mix, first concentrate the filtrate to when 80 DEG C the closeest
Degree is the concentrated solution of 1.32, sets to 0~5 DEG C of deepfreezes 24 hours;The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, filter
Liquid is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, adds component 1 and stirs and make granule, subpackage;
Brew with boiled water during use.
9. the Chinese medicine fumigation and washing soaking agent treating talalgia as according to any one of claims 1 to 3, it is characterised in that institute
The preparation process stating Chinese medicine fumigation and washing soaking agent can also be:
A. take Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and the Rhizoma Et Radix Notopterygii way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1;
B. by remaining raw material ethanol extraction 2 times, concentrate, as component 2;
C. pelletize after component 1, component 2 being mixed, subpackage.
Treat the preparation method of talalgia Chinese medicine fumigation and washing soaking agent the most according to claim 9, it is characterised in that described step
In rapid a, first crude drug Radix Notoginseng, the Radix Angelicae Dahuricae, Myrrha, Olibanum and Rhizoma Et Radix Notopterygii steam method is distilled, obtains crystal, then pulverize,
Cross 100-120 mesh sieve, standby as component 1;In described step b, remaining crude drug is steeped in 10 times amount ethanol, soak 1-2
Hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then through the molecular weight that dams
For the ultrafiltration post ultrafiltration of 5000-10000, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2;
In described step c, component 1 is put in component 2, stirs, make granule, subpackage;Brew with boiled water during use.
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CN106420542A (en) * | 2016-12-19 | 2017-02-22 | 杨凌萃健生物工程技术有限公司 | Footbath liquid and preparation method thereof |
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CN100998799A (en) * | 2006-12-27 | 2007-07-18 | 陈玉龙 | Chinese medicinal preparation for treating fracture, traumatic injury |
CN104306495A (en) * | 2014-10-30 | 2015-01-28 | 青岛恒波仪器有限公司 | External traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method thereof |
CN105343625A (en) * | 2015-12-04 | 2016-02-24 | 青岛安倍康生物医药技术有限公司 | Taraxacum oral liquid for expelling toxin, dehumidifying and benefiting gallbladder and preparation method thereof |
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CN100998799A (en) * | 2006-12-27 | 2007-07-18 | 陈玉龙 | Chinese medicinal preparation for treating fracture, traumatic injury |
CN104306495A (en) * | 2014-10-30 | 2015-01-28 | 青岛恒波仪器有限公司 | External traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method thereof |
CN105343625A (en) * | 2015-12-04 | 2016-02-24 | 青岛安倍康生物医药技术有限公司 | Taraxacum oral liquid for expelling toxin, dehumidifying and benefiting gallbladder and preparation method thereof |
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CN106420542A (en) * | 2016-12-19 | 2017-02-22 | 杨凌萃健生物工程技术有限公司 | Footbath liquid and preparation method thereof |
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