CN104815148B - A kind of pharmaceutical composition for treating the proliferation of mammary gland - Google Patents
A kind of pharmaceutical composition for treating the proliferation of mammary gland Download PDFInfo
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- CN104815148B CN104815148B CN201510200338.6A CN201510200338A CN104815148B CN 104815148 B CN104815148 B CN 104815148B CN 201510200338 A CN201510200338 A CN 201510200338A CN 104815148 B CN104815148 B CN 104815148B
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Abstract
The invention discloses a kind of pharmaceutical compositions for treating the proliferation of mammary gland, include the bulk pharmaceutical chemicals of following parts by weight：30 45 parts of okra complete stool, 30 45 parts of Radix Astragali, 20 30 parts of blood clam, 20 30 parts of rhizoma cyperi, 18 25 parts of Radix Angelicae Sinensis, 18 25 parts of seaweed, 10 15 parts of the rhizome of davallia, 10 15 parts of radix bupleuri, 5 12 parts of Herba Epimedii, 5 12 parts of Semen Cuscutae, 38 parts of fritillaria thunbergii, 38 parts of Radix Salviae Miltiorrhizae, 38 parts of oryzanol, 38 parts of salvia chinensis.Unique formula of the invention, each bulk pharmaceutical chemicals collaboration work, and have the function of dispersing stagnated hepatoqi, blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses, work to the proliferation of mammary gland quick, curative for effect.
Description
Technical field
The present invention relates to a kind of compositions, and in particular to a kind of pharmaceutical composition for treating the proliferation of mammary gland belongs to Chinese medicine skill
Art field.
Background technology
The proliferation of mammary gland refers to breast epithelium and proliferation of fibrous tissue, the regression of breast tissue conduit and newborn leaflet in structure
Venereal disease becomes and the growth of progressive connective tissue.It is the most common breast disease of women, pathogenic factor is mainly due to interior point
Krinin dyssecretosis is related with mental element.Traditional Chinese Medicine think it be due to depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis,
Caused by phlegm congeals into core, Chong and Ren channel disorder, traditional Chinese medicine is referred to as " newborn addiction ".Modern medicine then thinks that its generation develops and lapsed to
It is caused by the hormonal circadian variation in human female entirely.Spirit is excessively nervous, mood excessively excitement, the multiple stream of people, female
Hormone absolutely or relatively increases, and progestational hormone is absolutely or relative reduction, long-term use health products, contraceptive etc. containing estrogen all may be used
The proliferation of mammary gland can be caused.
Chinese medicine thinks, this sick pathogenic factor is mostly with internal organs dysfunction, qi-blood disharmony related, and women is sentimental, and one is not
Satisfactory, the fire of conscience is sprung into life, and Liver Channel promoting lactation circulation two is coerced, and obstruction of the circulation of vital energy phlegm is caused to coagulate in breast.So Chinese medicine is generally adopted
It is treated with the method for liver soothing and depression relief, promoting the circulation of qi resolving sputum.
Invention content
The object of the present invention is to provide a kind of pharmaceutical composition for treating the proliferation of mammary gland, the composition have dispersing stagnated hepatoqi,
The effect of blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses, can fast and effeciently prevent and treat the proliferation of mammary gland.
The present invention is achieved by the following measures：
A kind of pharmaceutical composition for treating the proliferation of mammary gland, it is characterized in that including the bulk pharmaceutical chemicals of following parts by weight：Okra is complete
30-45 parts of strain, 30-45 parts of Radix Astragali, 20-30 parts of blood clam, 20-30 parts of rhizoma cyperi, 18-25 parts of Radix Angelicae Sinensis, 18-25 parts of seaweed, bone is broken
10-15 parts of benefit, 10-15 parts of radix bupleuri, 5-12 parts of Herba Epimedii, 5-12 parts of Semen Cuscutae, 3-8 parts of fritillaria thunbergii, 3-8 parts of Radix Salviae Miltiorrhizae, oryzanol
3-8 parts, 3-8 parts of salvia chinensis.
Aforementioned pharmaceutical compositions preferably include the bulk pharmaceutical chemicals of following parts by weight：35 parts of okra complete stool, 35 parts of Radix Astragali, corrugation
25 parts of son, 25 parts of rhizoma cyperi, 20 parts of Radix Angelicae Sinensis, 20 parts of seaweed, 12 parts of the rhizome of davallia, 12 parts of radix bupleuri, 10 parts of Herba Epimedii, 10 parts of Semen Cuscutae,
5 parts of fritillaria thunbergii, 5 parts of Radix Salviae Miltiorrhizae, 5 parts of oryzanol, 5 parts of salvia chinensis.
The selected 14 taste medicinal material of the present invention is used as bulk pharmaceutical chemicals, and all medicines share is with dispersing stagnated hepatoqi, blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses
Effect, each bulk pharmaceutical chemicals effect are as follows：
Okra, alias gumbo（Scientific name：Abelmoschus esculentus）, ambrette, foreign eggplant, goat's horn dish, swordweed,
Goat's horn green pepper, foreign capsicum, are the annual herbaceous plant of Malvaceae.Okra complete stool includes root, leaf and fruit pod, rich in abundant
Vitamin and trace element have the function of clearing heat and promoting diuresis, protection liver, strong kidney qi-restoratives, antifatigue.
Radix Astragali, legume astragalus mongolicus, Astragalus membranacus root, have invigorating qi for strengthening superficies, profit water detumescence, pus draining and toxin expelling, life
Flesh and other effects.Nature and flavor are sweet, tepor, the diseases such as do not hold back long for spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or burst.
Blood clam, the shell of blood clam section animal chief blood clam, mud blood clam and blood clam, have dissolving phlegm softening hard masses, blood stasis-eliminating and stagnation-dissipating, relieving haperacidity analgesic
Effect cures mainly chronic phlegm product knot, scrofula, goiter and tumor , abdominal mass and lump.
Rhizoma cyperi, the dry rhizome of sedge nutgrass flatsedge have the effect of promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving, are used for liver depression gas
It is stagnant, chest side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia stomachache, swollen breasts, irregular menstruation, closed dysmenorrhea.
There is tonifying blood and regulating menstruation, promoting blood circulation and stopping pain to wither for the deficiency of blood the effect of relaxing bowel for Radix Angelicae Sinensis, the root of Umbelliferae Radix Angelicae Sinensis
Huang, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.
The drying frond of seaweed, Sargassaceae plant Sargassum or sargassum fusifome has softening and resolving hard mass, dissolving phlegm, the work(of Li Shui
Effect is used for goiter and tumor, scrofula, testiclar gall, phlegm and retained fluid oedema.
The rhizome of davallia has the effect of The strong bone of kidney tonifying, continues and hinders pain relieving, is used for lumbago due to the kidney deficiency, Hiccough and deaf, and tooth mobility falls
It winks and frustrates, injured bone.
The dry root of radix bupleuri, umbelliferae bupleurum or radix bupleuri scorzoneraefolii, have and inducing diaphoresis in, it is soothing the liver, the effect of rising Yang, use
In cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, rectal prolapse.
Herba Epimedii, Berberidaceae plant Herba Epimedii, Epimedium sagittatum, E. Pubescens, E. wushanense T. S. Ying or korean epimedium herb
Dry aerial parts, there is kidney-replenishing, the effect of strengthening the bones and muscles, wind-damp dispelling, be used for impotence and seminal emission, muscles and bones impotence, arthralgia pain due to rheumatism,
Numbness contracture.
Semen Cuscutae, the seed of Convolvulaceae Semen Cuscutae have tonifying kidney and benefiting sperm, the effect of nourishing the liver to improve visual acuity, are suitable for kidney deficiency and liver
Waist and knee muscles and bones ache, legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, dripping urination, it is dizzy, regard object not
Clearly, Hiccough and deaf and women are under, the diseases such as habitual abortion.
Fritillaria thunbergii, the dry bulb of liliaceous plant fritillaria thunbergii have the effect of heat-clearing dissipating bind, preventing phlegm from forming and stopping coughing, are used for wind
Heat violates lung, phlegm-fire cough, lung carbuncle, acute mastitis, scrofula, sore.
Radix Salviae Miltiorrhizae, the drying root and rhizome of labiate Radix Salviae Miltiorrhizae have stasis-dispelling and pain-killing, invigorate blood circulation, the work(of relieving restlessness that clears away heart-fire
Effect is used for irregular menstruation, and closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Liver and spleen is swollen
Greatly, angina pectoris.
Oryzanol has the effects that reduce blood fat, improves vegetative nerve function, sets the mind at rest, anxiety reduction, can be used for U.S.
Hold, be also commonly used for premenstrual syndrome, menopausal syndrome auxiliary treatment.
Salvia chinensis, the herb of labiate Salvia chinensis have effects that promoting blood circulation and removing blood stasis, clearing heat and promoting diuresis, mass dissipating and swelling eliminating,
Cure mainly irregular menstruation, dysmenorrhoea, Amenorrhea, uterine bleeding has blood in stool, treating rheumatic ostealgia, scrofula, sore swells, acute mastitis etc..
Present composition preparation method is simple, and each bulk pharmaceutical chemicals are uniformly mixed, and is ground into 80-100 targeted fine powders, i.e.,
It can.In order to convenient to take, can also capsule, tablets and other formulations be made using conventional method.
Pharmaceutical composition of the present invention 3 times a day, is calculated as 3-6g with bulk pharmaceutical chemicals every time when in use.
Unique formula of the invention, each bulk pharmaceutical chemicals collaboration work, and have the function of dispersing stagnated hepatoqi, blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses,
It works to the proliferation of mammary gland quick, it is curative for effect.
Specific implementation mode
The present invention is further detailed below by specific embodiment, following the description only plays illustrative work
With not limiting its content.Unless otherwise instructed, following raw material medicaments are parts by weight.
Embodiment 1
Pharmaceutical formulation is as follows：35 parts of okra complete stool, 35 parts of Radix Astragali, 25 parts of blood clam, 25 parts of rhizoma cyperi, 20 parts of Radix Angelicae Sinensis, sea
20 parts of algae, 12 parts of the rhizome of davallia, 12 parts of radix bupleuri, 10 parts of Herba Epimedii, 10 parts of Semen Cuscutae, 5 parts of fritillaria thunbergii, 5 parts of Radix Salviae Miltiorrhizae, 5 parts of oryzanol,
5 parts of salvia chinensis.
Preparation method is：Each bulk pharmaceutical chemicals are uniformly mixed, be ground into 80-100 targeted fine powders to get.
Embodiment 2
Pharmaceutical formulation is as follows：30 parts of okra complete stool, 45 parts of Radix Astragali, 20 parts of blood clam, 30 parts of rhizoma cyperi, 18 parts of Radix Angelicae Sinensis, sea
25 parts of algae, 10 parts of the rhizome of davallia, 15 parts of radix bupleuri, 5 parts of Herba Epimedii, 12 parts of Semen Cuscutae, 3 parts of fritillaria thunbergii, 8 parts of Radix Salviae Miltiorrhizae, 3 parts of oryzanol,
8 parts of salvia chinensis.
The preparation method is the same as that of Example 1.
Embodiment 3
Pharmaceutical formulation is as follows：45 parts of okra complete stool, 30 parts of Radix Astragali, 30 parts of blood clam, 20 parts of rhizoma cyperi, 25 parts of Radix Angelicae Sinensis, sea
18 parts of algae, 15 parts of the rhizome of davallia, 10 parts of radix bupleuri, 12 parts of Herba Epimedii, 5 parts of Semen Cuscutae, 8 parts of fritillaria thunbergii, 3 parts of Radix Salviae Miltiorrhizae, 8 parts of oryzanol,
3 parts of salvia chinensis.
The preparation method is the same as that of Example 1.
Embodiment 4
Pharmaceutical formulation is as follows：30 parts of okra complete stool, 30 parts of Radix Astragali, 30 parts of blood clam, 30 parts of rhizoma cyperi, 18 parts of Radix Angelicae Sinensis, sea
18 parts of algae, 15 parts of the rhizome of davallia, 15 parts of radix bupleuri, 5 parts of Herba Epimedii, 5 parts of Semen Cuscutae, 8 parts of fritillaria thunbergii, 8 parts of Radix Salviae Miltiorrhizae, 3 parts of oryzanol, stone
See and wears 5 parts.
The preparation method is the same as that of Example 1.
Embodiment 5
Pharmaceutical formulation is as follows：45 parts of okra complete stool, 45 parts of Radix Astragali, 20 parts of blood clam, 20 parts of rhizoma cyperi, 25 parts of Radix Angelicae Sinensis, sea
25 parts of algae, 10 parts of the rhizome of davallia, 10 parts of radix bupleuri, 12 parts of Herba Epimedii, 12 parts of Semen Cuscutae, 3 parts of fritillaria thunbergii, 3 parts of Radix Salviae Miltiorrhizae, 8 parts of oryzanol,
8 parts of salvia chinensis.
The preparation method is the same as that of Example 1.
Embodiment 6
Pharmaceutical formulation is as follows：45 parts of okra complete stool, 45 parts of Radix Astragali, 30 parts of blood clam, 30 parts of rhizoma cyperi, 25 parts of Radix Angelicae Sinensis, sea
18 parts of algae, 10 parts of the rhizome of davallia, 10 parts of radix bupleuri, 5 parts of Herba Epimedii, 5 parts of Semen Cuscutae, 3 parts of fritillaria thunbergii, 8 parts of Radix Salviae Miltiorrhizae, 8 parts of oryzanol, stone
See and wears 3 parts.
The preparation method is the same as that of Example 1.
In the following, by partial clinical experiments have shown that the effect of drug of the present invention
1, patient source
The proliferation of mammary gland patient gone to a doctor in this city hospital outpatient is selected to be tested, totally 276,25 years old age~60
Year, average age 38.4 years old, patient have following at least one clinical symptoms：1）Unilateral or bilateral swollen breasts and secret anguish, the moon
The pain increased when premenstrual and mood swing；2）Unilateral or bilateral differs in size, in the form of sheets, plate-like, graininess, streak, quality
It is flexible, obscure boundary, with skin without adhesion, have the lump in breast of tenderness；3）Breast molybdenum target X-ray film is shown in more uniform increase in density
Shadow.
, therapy
Above-mentioned patient is equally divided into 4 groups, no difference of science of statistics between each group is comparable, every group of 69 people.Each group is suffered from
Person takes the drug of the embodiment of the present invention 1,2,3 and 5 respectively, and 3 times a day, each 5g, the menstrual period withdraws.
, criterion of therapeutical effect
It is effective：Lump in breast, pain completely disappear or breast pain obviously disappears, and lump major diameter reduces ＞ 1/2；
Effectively：Lump in breast softens, and major diameter reduces ＞ 1/3, while pain relief or disappearance；
In vain：Lump in breast major diameter is without diminution, and the symptoms such as pain are without significant change.
, treatment results
For each group patient continuous use after 2 months, treatment is as shown in the table：
| Effective number | Efficiently individual quantity | Invalid number | It is efficient | |
| Embodiment 1 | 37 | 32 | 0 | 100% |
| Embodiment 2 | 23 | 39 | 7 | 89.9% |
| Embodiment 3 | 23 | 38 | 8 | 88.4% |
| Embodiment 5 | 27 | 38 | 4 | 94.2% |
Claims (2)
1. a kind of pharmaceutical composition for treating the proliferation of mammary gland, it is characterized in that being made of the bulk pharmaceutical chemicals of following parts by weight：Okra is complete
30-45 parts of strain, 30-45 parts of Radix Astragali, 20-30 parts of blood clam, 20-30 parts of rhizoma cyperi, 18-25 parts of Radix Angelicae Sinensis, 18-25 parts of seaweed, bone is broken
10-15 parts of benefit, 10-15 parts of radix bupleuri, 5-12 parts of Herba Epimedii, 5-12 parts of Semen Cuscutae, 3-8 parts of fritillaria thunbergii, 3-8 parts of Radix Salviae Miltiorrhizae, oryzanol
3-8 parts, 3-8 parts of salvia chinensis.
2. pharmaceutical composition according to claim 1, it is characterized in that being made of the bulk pharmaceutical chemicals of following parts by weight：Okra is complete
35 parts of strain, 35 parts of Radix Astragali, 25 parts of blood clam, 25 parts of rhizoma cyperi, 20 parts of Radix Angelicae Sinensis, 20 parts of seaweed, 12 parts of the rhizome of davallia, 12 parts of radix bupleuri are excessive
10 parts of the sheep leaves of pulse plants, 10 parts of Semen Cuscutae, 5 parts of fritillaria thunbergii, 5 parts of Radix Salviae Miltiorrhizae, 5 parts of oryzanol, 5 parts of salvia chinensis.
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Citations (5)
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|---|---|---|---|---|
| CN1985939A (en) * | 2005-12-19 | 2007-06-27 | 李文东 | Tablet for treating mastosis and its preparing method |
| CN101002847A (en) * | 2006-12-11 | 2007-07-25 | 三峡大学第一临床医学院 | Medicine for treating mazoplasia, and its preparing method |
| CN101810744A (en) * | 2009-12-11 | 2010-08-25 | 律北平 | Formula of orally-taken Chinese medicament for treating hyperplasia of mammary glands |
| CN102178828A (en) * | 2011-04-21 | 2011-09-14 | 安徽省药物研究所 | Medicament for treating proliferation of mammary gland and preparation method thereof |
| CN103919984A (en) * | 2014-05-10 | 2014-07-16 | 陈筠 | Traditional Chinese medicine composition for treating mammary gland hyperplasia |
-
2015
- 2015-04-27 CN CN201510200338.6A patent/CN104815148B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985939A (en) * | 2005-12-19 | 2007-06-27 | 李文东 | Tablet for treating mastosis and its preparing method |
| CN101002847A (en) * | 2006-12-11 | 2007-07-25 | 三峡大学第一临床医学院 | Medicine for treating mazoplasia, and its preparing method |
| CN101810744A (en) * | 2009-12-11 | 2010-08-25 | 律北平 | Formula of orally-taken Chinese medicament for treating hyperplasia of mammary glands |
| CN102178828A (en) * | 2011-04-21 | 2011-09-14 | 安徽省药物研究所 | Medicament for treating proliferation of mammary gland and preparation method thereof |
| CN103919984A (en) * | 2014-05-10 | 2014-07-16 | 陈筠 | Traditional Chinese medicine composition for treating mammary gland hyperplasia |
Non-Patent Citations (3)
| Title |
|---|
| 中药结合食疗治疗乳腺增生病疗效观察;胡艳聆等;《中国煤炭工业医学杂志》;20060228;第9卷(第02期);第199页 * |
| 分型辨治乳腺增生病;阙华发等;《辽宁中医杂志》;19990618;第26卷(第06期);第259-260页 * |
| 温阳活血汤治愈乳腺增生病2例;李金娥;《江西中医药》;19941230;第25卷;第54-55页 * |
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