CN1985939A - Tablet for treating mastosis and its preparing method - Google Patents
Tablet for treating mastosis and its preparing method Download PDFInfo
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- CN1985939A CN1985939A CNA2005100325752A CN200510032575A CN1985939A CN 1985939 A CN1985939 A CN 1985939A CN A2005100325752 A CNA2005100325752 A CN A2005100325752A CN 200510032575 A CN200510032575 A CN 200510032575A CN 1985939 A CN1985939 A CN 1985939A
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Abstract
The present invention belongs to the field of Chinese medicine technology, and is especially mastosis treating tablet and its preparation process. The mastosis treating tablet is prepared with oyster seaweed, kelp, spatholobus stem, epimedium and other Chinese medicinal materials. It is used in treating hyperplasia of mammary glands, mammary tumor, mastalgia and other mastosis. Compared with available similar medicine, the mastosis treating tablet has small dosage.
Description
Technical field:
The present invention relates to a kind of Chinese patent medicine, particularly a kind of can substituting has particulate a kind of tablet for treating mastosis of Chinese patent medicine breast disease spirit and preparation method thereof.
Background technology:
Newborn disease spirit granule in China's the Sanitation Ministry medicine standard has soothing liver-QI for relieving depression, the effect of mass dissipating and swelling eliminating.Be mainly used in cyclomastopathy, diseases such as mammary gland tumor, distension pain.Clinical practice is extensive, has certain curative effect, and its production technology is also ripe.But because of the active ingredient in the granule only accounts for 23.8% of medicine gross weight.Because adjuvant is too many, increased the cost of medicine, the dose that the patient need take is also big especially.
Summary of the invention:
The object of the present invention is to provide a kind of existing definite curative effect, can reduce drug dose at double again, and the also lower a kind of tablet for treating mastosis of cost and preparation method thereof.
The objective of the invention is to realize by following technical proposals: improve dosage form on the basis of existing Chinese patent medicine breast disease spirit granular recipe, it is characterized in that: the Chinese patent medicine after the molding is a tablet, and the medicine active ingredient accounts for the 70%-85% of medicine gross weight.The preparation method of tablet for treating mastosis is improved on the basis of the particulate production method of existing newborn disease spirit, it is characterized in that:
When a, Semen Vaccariae decocting in water precipitate with ethanol, add dose 10-14 water logging bubble doubly for the first time and decocted 1-2 hour after 0.5-1.5 hour, add dose 10-14 decocting doubly for the second time again and boiled 0.5-1.5 hour;
11 flavor Chinese medicine decocting in water twice such as b, other Caulis Spatholobis add medicine total amount 8-12 decocting doubly for the first time and boiled 1-3 hour, add medicine total amount 8-12 decocting doubly for the second time again and boil 1-2 hour;
C, with the said medicine extract merge be condensed into extractum after, drying gets dry extract, and pulverizes dried cream, the microcrystalline cellulose excipients of the 10-21.5% of each dried cream weight and hydroxypropyl cellulose again, mixing, alcohol granulation, drying, compress tablet coating promptly
Implement the present invention, under the prerequisite that the medicine active ingredient is not done to change, owing to significantly reduced the consumption of adjuvant, the medicine production cost will lower naturally.Simultaneously, same disease is used granule, and will take medicine every day 42-84 gram of patient only need be taken the 5.4-10.8 gram every day and take tablet for treating mastosis provided by the invention.
The specific embodiment:
The particulate prescription of newborn disease spirit in the standard for traditional Chinese medicines of the prescription of tablet for treating mastosis of the present invention and China's Ministry of Public Health is just the same.That is: Concha Ostreae 18.2%, Sargassum, Thallus Laminariae (Thallus Eckloniae), Caulis Spatholobi, Herba Epimedii, Semen Cuscutae each 9.1%, Semen Vaccariae, Radix Salviae Miltiorrhizae each 7.3%, Radix Bupleuri, Rhizoma Cyperi, Radix Paeoniae Rubra, Pericarpium Citri Reticulatae Viride each 5.4%.Just after the extract of said medicine is made extractum, former granule is to get with sucrose, dextrin mixing, granulation, drying.And tablet for treating mastosis of the present invention is that extract dry is become dried cream, pulverizes, and adds microcrystalline Cellulose, hydroxypropyl cellulose mixing, alcohol granulation, drying, compress tablet coating and getting.The final molding tablet.And the effective ingredient of granule only accounts for 23.8% of medicine total content, and tablet medicine active ingredient of the present invention accounts for the 70%-85% of medicine gross weight.Obviously, adjuvant how much be adjustable, can be 75%, 80% or the like, even also can be lower than 70%, or be higher than 85%.
The preparation method of tablet for treating mastosis is also basic identical with newborn disease spirit granule.That is:
A, Semen Vaccariae need carry out the decocting in water precipitate with ethanol separately, only the present invention is by experimental study, further clear and definite Semen Vaccariae is being carried out the decocting in water precipitate with ethanol when extracting, decocting in water preferably carries out twice, adds dose 10-14 water logging bubble doubly for the first time and decocts 1-2 hour after 0.5-1.5 hour, the decocting that adds for the second time 12 times of doses again boiled 1 hour, be both economical rational like this, if decoct three times, though last dried cream yield can improve, but few, consider it is non-remunerative from economic angle.Extracted twice liquid is merged, under 70-80 ℃ temperature, extracting solution is condensed into relative density and is the clear paste of 1.05-1.15 (70-80 ℃ time survey), after being chilled to room temperature, the ethanol cooling of adding and the equiponderant 90-98% of clear paste 24 hours, make its precipitation, remove supernatant (reclaiming the ethanol reuse), liquid must sink.
The method that b, other Caulis Spatholobis etc. 11 flavor Chinese medicine decocting in water extract is basic identical with granule also, twice of only the present invention is further clear and definite decocting in water, add for the first time medicine total amount 8-12 decocting doubly and boiled 1-3 hour, add medicine total amount 8-12 decocting doubly for the second time and boiled 1-2 hour.
C, drug extracts such as Semen Vaccariae and Caulis Spatholobi are merged, be condensed into the extractum that relative density is 1.30-1.50 under 50-60 ℃ temperature, at the pressure of 0.05-0.1Mpa, powdered extract gets dry extract under 60-70 ℃ the temperature again.Pulverize dried cream, each adds microcrystalline cellulose excipients and the hydroxypropyl cellulose of dried cream weight 10%-21.5%, behind the mixing, uses alcohol granulation, drying, compress tablet coating.
Claims (2)
1, a kind of tablet for treating mastosis improves dosage form on the basis of existing Chinese patent medicine breast disease spirit granular recipe, it is characterized in that: the Chinese patent medicine after the molding is a tablet, and the medicine active ingredient accounts for the 70%-85% of medicine gross weight.
2, the preparation method of a kind of tablet for treating mastosis according to claim 1 is improved on the basis of the particulate production method of existing newborn disease spirit, it is characterized in that:
When a, Semen Vaccariae decocting in water precipitate with ethanol, add dose 10-14 water logging bubble doubly for the first time and decocted 1-2 hour after 0.5-1.5 hour, add dose 10-14 decocting doubly for the second time again and boiled 0.5-1.5 hour;
11 flavor Chinese medicine decocting in water twice such as b, other Caulis Spatholobis add medicine total amount 8-12 decocting doubly for the first time and boiled 1-3 hour, add medicine total amount 8-12 decocting doubly for the second time again and boil 1-2 hour;
C, with the said medicine extract merge be condensed into extractum after, powdered extract gets dry extract, and pulverizes dried cream, respectively adds microcrystalline cellulose excipients and the hydroxypropyl cellulose of 10-21.5% again, mixing, alcohol granulation, drying, compress tablet coating.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNA2005100325752A CN1985939A (en) | 2005-12-19 | 2005-12-19 | Tablet for treating mastosis and its preparing method |
Applications Claiming Priority (1)
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CNA2005100325752A CN1985939A (en) | 2005-12-19 | 2005-12-19 | Tablet for treating mastosis and its preparing method |
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CN1985939A true CN1985939A (en) | 2007-06-27 |
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CNA2005100325752A Pending CN1985939A (en) | 2005-12-19 | 2005-12-19 | Tablet for treating mastosis and its preparing method |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104815148A (en) * | 2015-04-27 | 2015-08-05 | 吴联合 | Pharmaceutical composition for treating hyperplasia of mammary glands |
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2005
- 2005-12-19 CN CNA2005100325752A patent/CN1985939A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104815148A (en) * | 2015-04-27 | 2015-08-05 | 吴联合 | Pharmaceutical composition for treating hyperplasia of mammary glands |
CN104815148B (en) * | 2015-04-27 | 2018-08-21 | 吴联合 | A kind of pharmaceutical composition for treating the proliferation of mammary gland |
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