CN103830674A - Medicament composition for treating lipomyoma and preparation method and application thereof - Google Patents
Medicament composition for treating lipomyoma and preparation method and application thereof Download PDFInfo
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- CN103830674A CN103830674A CN201410068476.9A CN201410068476A CN103830674A CN 103830674 A CN103830674 A CN 103830674A CN 201410068476 A CN201410068476 A CN 201410068476A CN 103830674 A CN103830674 A CN 103830674A
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Abstract
The invention discloses a medicament composition for treating lipomyoma. The medicament is prepared from the following raw materials: poria cocos, selfheal, fructus forsythiae, semen brassicae, thunberg fritillary bulb, concha meretricis seu cyclinae, concha arcae, curcuma zedoary, caulis bambusae in taeniam, immature bitter orange, rhizoma pinellinae praeparata, dried tangerine or orange peel and liquorice. A preparation method comprises the following steps: 1, weighing concha meretricis seu cyclinae and concha arcae according to a ratio, mixing up, soaking with water and decocting; 2, weighing poria cocos, selfheal, fructus forsythiae, semen brassicae, thunberg fritillary bulb, curcuma zedoary, caulis bambusae in taeniam, immature bitter orange, rhizoma pinellinae praeparata, dried tangerine or orange peel and liquorice according to a ratio, mixing up and adding water; 3, mixing the medicine decoction and the medicine residues obtained in the step 1 with medicines processed in the step 2, decocting, and filtering to obtain water decoction, wherein medicine residues are for later use; 4, adding water to the medicine residues obtained in the step 3, decocting, filtering to obtain water decoction and discarding the medicine residues; and 5, mixing the water decoction obtained in the step 3 and the water decoction obtained in the step 4, concentrating into extractum, drying, crushing and adding auxiliary materials so as to obtain the medicament composition. The medicament composition is simple in preparation, novel in formula, low in cost, good in curative effect, free of toxic or side effect, unlikely to have medicine resistance, convenient to take and carry and applicable to patients with lipomyoma.
Description
Technical field
The present invention relates to one and treat lipomatous pharmaceutical composition and preparation method thereof.
Background technology
Lipoma is the benign tumor that originates from fatty tissue, is made up of ripe fatty tissue, and the position that has fat to exist in all bodies all can occur, and lipoma has the fiber inner membrance that one deck is thin, inside has a lot of fiber ropes, forms in length and breadth a lot of intervals.Be most commonly in the subcutaneous tissue of neck, shoulder, the back of the body, buttocks and breast and limbs, face, scalp, scrotum and labia, be secondly after peritoneum and gastrointestinal wall etc. located; Only a few can come across the position of original fat-free mass, if fibrous tissue proportion is more in tumor, claims fibrolipoma.According to having isolatism lipoma and lipomatosis lipomatous can number can being divided into.Tumor body constitution ground is soft, and circle or lobulated are positioned at subcutaneously, can promote; Not etc., little is as not large in Fructus Jujubae for tumorous size, and touching with hands can stereognosis, large swelled surface, but surface skin is normal, many no conscious symptons.The patient who seeks medical advice because of subcutaneous fat tumor is clinically more, and the mood of especially seeking medical advice with blue or green, middle aged patient is the most urgent.Often advise that for less subcutaneous fat tumor doctor trained in Western medicine patient is without treatment, to be viewed as master, without the treatment of any specific drugs, for larger subcutaneous fat tumor take excision as main.Subcutaneous fat tumor belongs to the category of the traditional Chinese medical science " physocele ", " sarcoma ", " sucutaneous nodule ", and depressed, blood stasis, expectorant is solidifying is the Basic disease cause of primary disease, by obtaining satisfied clinical efficacy after promoting flow of QI and blood blood stasis dispelling treatment.
Summary of the invention
One object of the present invention is to overcome the deficiencies in the prior art, provide a kind of composition simple, the lipomatous pharmaceutical composition for the treatment of of filling a prescription novel, this pharmaceutical composition has that cost is low, good effect, have no side effect, be difficult for producing toleration, take and easy to carry, be generally applicable to the features such as lipomatous patient.
Another object of the present invention is to provide a kind of preparation method for the treatment of lipomatous pharmaceutical composition, and this preparation method is simple to operate, applicable to suitability for industrialized production.
The object of the invention is to be achieved through the following technical solutions: one is treated lipomatous pharmaceutical composition, it is characterized in that: it is made up of the raw material of following ratio of weight and number: 15～60 parts, Poria, 10～50 parts of Spica Prunellaes, 10～50 parts of Fructus Forsythiaes, 10～50 parts of Semen Sinapis Albaes, 10～50 parts of Bulbus Fritillariae Thunbergiis, 10～50 parts of Concha Meretricis seu Cyclinaes, 10～50 parts of Concha Arcaes, 10～50 parts of Rhizoma Curcumae, 10～50 parts of Caulis Bambusae In Taenia, 10～50 parts of Fructus Aurantii Immaturuss, 5～40 parts of Rhizoma Pinelliae Preparatum, 5～40 parts of Pericarpium Citri Reticulataes, 1～10 part, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: 20～50 parts, Poria, 15～40 parts of Spica Prunellaes, 15～40 parts of Fructus Forsythiaes, 15～40 parts of Semen Sinapis Albaes, 15～40 parts of Bulbus Fritillariae Thunbergiis, 15～40 parts of Concha Meretricis seu Cyclinaes, 15～40 parts of Concha Arcaes, 15～40 parts of Rhizoma Curcumae, 15～40 parts of Caulis Bambusae In Taenia, 15～40 parts of Fructus Aurantii Immaturuss, 10～30 parts of Rhizoma Pinelliae Preparatum, 10～30 parts of Pericarpium Citri Reticulataes, 3～8 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: 25～40 parts, Poria, 20～35 parts of Spica Prunellaes, 20～35 parts of Fructus Forsythiaes, 20～35 parts of Semen Sinapis Albaes, 20～35 parts of Bulbus Fritillariae Thunbergiis, 20～35 parts of Concha Meretricis seu Cyclinaes, 20～35 parts of Concha Arcaes, 20～35 parts of Rhizoma Curcumae, 20～35 parts of Caulis Bambusae In Taenia, 20～35 parts of Fructus Aurantii Immaturuss, 15～25 parts of Rhizoma Pinelliae Preparatum, 15～25 parts of Pericarpium Citri Reticulataes, 4～6 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: 30 parts, Poria, 25 parts of Spica Prunellaes, 25 parts of Fructus Forsythiaes, 25 parts of Semen Sinapis Albaes, 25 parts of Bulbus Fritillariae Thunbergiis, 25 parts of Concha Meretricis seu Cyclinaes, 25 parts of Concha Arcaes, 25 parts of Rhizoma Curcumae, 25 parts of Caulis Bambusae In Taenia, 25 parts of Fructus Aurantii Immaturuss, 20 parts of Rhizoma Pinelliae Preparatum, 20 parts of Pericarpium Citri Reticulataes, 5 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: 20 parts, Poria, 15 parts of Spica Prunellaes, 15 parts of Fructus Forsythiaes, 15 parts of Semen Sinapis Albaes, 15 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Concha Meretricis seu Cyclinaes, 15 parts of Concha Arcaes, 15 parts of Rhizoma Curcumae, 15 parts of Caulis Bambusae In Taenia, 15 parts of Fructus Aurantii Immaturuss, 12 parts of Rhizoma Pinelliae Preparatum, 12 parts of Pericarpium Citri Reticulataes, 3 parts, Radix Glycyrrhizae.
A method of preparing above-mentioned any one pharmaceutical composition, is characterized in that: it comprises the following steps:
S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour;
S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material;
S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use;
S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard;
S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
Pharmaceutical preparation of the present invention is tablet, capsule, granule, powder or oral liquid.
Pharmaceutically acceptable adjuvant of the present invention comprises starch, magnesium stearate, dextrin and microcrystalline Cellulose.
The application of pharmaceutical composition of the present invention in preparation treatment lipoma medicine, preferably, the application of pharmaceutical composition of the present invention in preparation treatment subcutaneous fat tumor medicine.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition can be applied to patient by modes such as oral, suction or intestinal external administrations.Dosage form on described pharmaceutics comprises: the tablet that uses when oral administration, capsule, pill, powder, granule, syrup, oral liquid etc.; The freeze-dried powder and the injection etc. that in the time of intestinal external administration, use.
For above-mentioned dosage form can be realized, need in the time of these dosage forms of preparation, add the acceptable adjuvant of pharmacy, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are determined, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Concha Meretricis seu Cyclinae, Concha Arcae, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae in pharmaceutical composition of the present invention is Chinese medicine or its processed product that 2010 editions " Chinese Pharmacopoeia " Firsts record.Poria is the sclerotium of On Polyporaceae Poria, has the effect of promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming; Spica Prunellae is the fruit ear of Labiatae herbaceos perennial Spica Prunellae, has the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating; Fructus Forsythiae is the fruit of Oleaceae machaka Fructus Forsythiae, has heat-clearing and toxic substances removing, dispelling wind and heat pathogens, the effect of eliminating carbuncle eliminating stagnation; Semen Sinapis Albae is the dry mature seed of crucifer Caulis et Folium Sinapis albee, has and reduces phlegm by drink, the effect of mass dissipating and swelling eliminating; Bulbus Fritillariae Thunbergii is the bulb of Liliaceae herbaceos perennial Bulbus Fritillariae Thunbergii, has removing heat-phlegm, the effect of dissipating depression of QI eliminating stagnation; Concha Meretricis seu Cyclinae is the shell of the multiple sea clams such as Veneridae animal Conch Meretricis seu Cyclinae, Concha Meretricis Seu Cyclinae; Concha Arcae, for the shell of Carnis Arca inflata section animal Scapharca subcrenata, Tegillarca granosa or Scapharca broughtonii, has eliminating phlegm and softening indurated mass, the effect of blood stasis-eliminating and stagnation-dissipating; Rhizoma Curcumae is the rhizome of Zingiberaceae herbaceos perennial Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE, has removing blood stasis circulation of qi promoting, the effect of removing food stagnancy pain relieving; Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, has removing heat-phlegm, the effect relieving restlessness and preventing vomiting; The dry young fruit of Fructus Aurantii Immaturus rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis, has dispelling the stagnated QI except painful abdominal mass, the effect of transforming phlegm and dispersing accumulations; Rhizoma Pinelliae Preparatum is the processed product of the Rhizoma Pinelliae, and the Rhizoma Pinelliae is the tuber of the aroid Rhizoma Pinelliae, has the effect of drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Pericarpium Citri Reticulatae is the mature peel of rutaceae orange and variety thereof, has the effect of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Root or rhizome that Radix Glycyrrhizae is glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., have the effect of QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.
The invention has the beneficial effects as follows: the present invention's novelty of filling a prescription, composition is simple, proves that by clinical research lipomatous patient is had to good clinical efficacy, in formula, each taste principal agent price is all comparatively cheap, holistic cost is cheap, and preparation method is simple to operate, applicable to suitability for industrialized production.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1:
Take raw material Poria 15g, Spica Prunellae 10g, Fructus Forsythiae 10g, Semen Sinapis Albae 10g, Bulbus Fritillariae Thunbergii 10g, Concha Meretricis seu Cyclinae 10g, Concha Arcae 10g, Rhizoma Curcumae 10g, Caulis Bambusae In Taenia 10g, Fructus Aurantii Immaturus 10g, Rhizoma Pinelliae Preparatum 5g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 1g, add supplementary product starch 100g to granulate, magnesium stearate 5g, dextrin 100g, microcrystalline Cellulose 100g, evenly make granule, tabletting, obtains tablet.
Embodiment 2:
Take raw material Poria 60g, Spica Prunellae 50g, Fructus Forsythiae 50g, Semen Sinapis Albae 50g, Bulbus Fritillariae Thunbergii 50g, Concha Meretricis seu Cyclinae 50g, Concha Arcae 50g, Rhizoma Curcumae 50g, Caulis Bambusae In Taenia 50g, Fructus Aurantii Immaturus 50g, Rhizoma Pinelliae Preparatum 40g, Pericarpium Citri Reticulatae 40g, Radix Glycyrrhizae 10g, add supplementary product starch 600g to granulate, magnesium stearate 30g, dextrin 500g, microcrystalline Cellulose 500g, evenly make granule, tabletting, obtains tablet.
Embodiment 3:
Take raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g part, Caulis Bambusae In Taenia 15g part, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 10g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 3g, add supplementary product starch 180g to granulate, magnesium stearate 12g, dextrin 120g, microcrystalline Cellulose 120g, evenly make granule, tabletting, obtains tablet.
Embodiment 4:
Take raw material Poria 50g, Spica Prunellae 40g, Fructus Forsythiae 40g, Semen Sinapis Albae 40g, Bulbus Fritillariae Thunbergii 40g, Concha Meretricis seu Cyclinae 40g, Concha Arcae 40g, Rhizoma Curcumae 40g, Caulis Bambusae In Taenia 40g, Fructus Aurantii Immaturus 40g, Rhizoma Pinelliae Preparatum 30g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 8g, add supplementary product starch 450g to granulate, magnesium stearate 30g, dextrin 350g, microcrystalline Cellulose 350g, evenly make granule, tabletting, obtains tablet.
Embodiment 5:
Take raw material Poria 25g, Spica Prunellae 20g, Fructus Forsythiae 20g, Semen Sinapis Albae 20g, Bulbus Fritillariae Thunbergii 20g, Concha Meretricis seu Cyclinae 20g, Concha Arcae 20g, Rhizoma Curcumae 20g, Caulis Bambusae In Taenia 20g, Fructus Aurantii Immaturus 20g, Rhizoma Pinelliae Preparatum 15g, Pericarpium Citri Reticulatae 15g, Radix Glycyrrhizae 4g, add supplementary product starch 250g to granulate, magnesium stearate 20g, dextrin 200g, microcrystalline Cellulose 200g, evenly make granule, tabletting, obtains tablet.
Embodiment 6:
Take raw material Poria 40g, Spica Prunellae 35g, Fructus Forsythiae 35g, Semen Sinapis Albae 35g, Bulbus Fritillariae Thunbergii 35g, Concha Meretricis seu Cyclinae 35g, Concha Arcae 35g, Rhizoma Curcumae 35g, Caulis Bambusae In Taenia 35g, Fructus Aurantii Immaturus 35g, Rhizoma Pinelliae Preparatum 25g, Pericarpium Citri Reticulatae 25g, Radix Glycyrrhizae 6g, add supplementary product starch 300g to granulate, magnesium stearate 30g, dextrin 250g, microcrystalline Cellulose 200g, evenly make granule, tabletting, obtains tablet.
Embodiment 7:
Take raw material Poria 30g, Spica Prunellae 25g, Fructus Forsythiae 25g, Semen Sinapis Albae 25g, Bulbus Fritillariae Thunbergii 25g, Concha Meretricis seu Cyclinae 25g, Concha Arcae 25g, Rhizoma Curcumae 25g, Caulis Bambusae In Taenia 25g, Fructus Aurantii Immaturus 25g, Rhizoma Pinelliae Preparatum 20g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 5g, add supplementary product starch 280g to granulate, magnesium stearate 20g, dextrin 200g, microcrystalline Cellulose 200g, evenly make granule, incapsulate, obtain capsule.
Embodiment 8:
Take raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g, adds supplementary product starch 180g to granulate, magnesium stearate 15g, dextrin 150g, microcrystalline Cellulose 150g, be prepared into granule according to common process.
Embodiment 9:
Take raw material Poria 30g, Spica Prunellae 25g, Fructus Forsythiae 25g, Semen Sinapis Albae 25g, Bulbus Fritillariae Thunbergii 25g, Concha Meretricis seu Cyclinae 25g, Concha Arcae 25g, Rhizoma Curcumae 25g, Caulis Bambusae In Taenia 25g, Fructus Aurantii Immaturus 25g, Rhizoma Pinelliae Preparatum 20g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 5g, adds supplementary product starch 280g to granulate, magnesium stearate 20g, dextrin 200g, microcrystalline Cellulose 200g, be prepared into oral liquid according to common process.
Embodiment 10:
Take raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g, adds supplementary product starch 180g to granulate, magnesium stearate 15g, dextrin 150g, microcrystalline Cellulose 150g, be prepared into powder according to common process.
Embodiment 11:
Take raw material Poria 15g, Spica Prunellae 10g, Fructus Forsythiae 10g, Semen Sinapis Albae 10g, Bulbus Fritillariae Thunbergii 10g, Concha Meretricis seu Cyclinae 10g, Concha Arcae 10g, Rhizoma Curcumae 10g, Caulis Bambusae In Taenia 10g, Fructus Aurantii Immaturus 10g, Rhizoma Pinelliae Preparatum 5g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 1g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into tablet.
Embodiment 12:
Take raw material Poria 60g, Spica Prunellae 50g, Fructus Forsythiae 50g, Semen Sinapis Albae 50g, Bulbus Fritillariae Thunbergii 50g, Concha Meretricis seu Cyclinae 50g, Concha Arcae 50g, Rhizoma Curcumae 50g, Caulis Bambusae In Taenia 50g, Fructus Aurantii Immaturus 50g, Rhizoma Pinelliae Preparatum 40g, Pericarpium Citri Reticulatae 40g, Radix Glycyrrhizae 10g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into tablet.
Embodiment 13:
Take raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g part, Caulis Bambusae In Taenia 15g part, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 10g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 3g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into capsule.
Embodiment 14:
Take raw material Poria 50g, Spica Prunellae 40g, Fructus Forsythiae 40g, Semen Sinapis Albae 40g, Bulbus Fritillariae Thunbergii 40g, Concha Meretricis seu Cyclinae 40g, Concha Arcae 40g, Rhizoma Curcumae 40g, Caulis Bambusae In Taenia 40g, Fructus Aurantii Immaturus 40g, Rhizoma Pinelliae Preparatum 30g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 8g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into granule.
Embodiment 15:
Take raw material Poria 25g, Spica Prunellae 20g, Fructus Forsythiae 20g, Semen Sinapis Albae 20g, Bulbus Fritillariae Thunbergii 20g, Concha Meretricis seu Cyclinae 20g, Concha Arcae 20g, Rhizoma Curcumae 20g, Caulis Bambusae In Taenia 20g, Fructus Aurantii Immaturus 20g, Rhizoma Pinelliae Preparatum 15g, Pericarpium Citri Reticulatae 15g, Radix Glycyrrhizae 4g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into oral liquid.
Embodiment 16:
Take raw material Poria 40g, Spica Prunellae 35g, Fructus Forsythiae 35g, Semen Sinapis Albae 35g, Bulbus Fritillariae Thunbergii 35g, Concha Meretricis seu Cyclinae 35g, Concha Arcae 35g, Rhizoma Curcumae 35g, Caulis Bambusae In Taenia 35g, Fructus Aurantii Immaturus 35g, Rhizoma Pinelliae Preparatum 25g, Pericarpium Citri Reticulatae 25g, Radix Glycyrrhizae 6g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into powder.
Embodiment 17:
Take raw material Poria 30g, Spica Prunellae 25g, Fructus Forsythiae 25g, Semen Sinapis Albae 25g, Bulbus Fritillariae Thunbergii 25g, Concha Meretricis seu Cyclinae 25g, Concha Arcae 25g, Rhizoma Curcumae 25g, Caulis Bambusae In Taenia 25g, Fructus Aurantii Immaturus 25g, Rhizoma Pinelliae Preparatum 20g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 5g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into tablet.
Embodiment 18:
Take raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g; Its preparation method comprises the following steps: S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour.S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add the conventional adjuvant of pharmacy to be prepared into capsule.
Verify beneficial effect of the present invention below by concrete clinical research:
1 physical data
Choose 52 routine lipoma patients, 20～70 years old age, male 28 examples, female's 24 examples.The course of disease is many at 6 months to 10 years, 42 years old mean age.
2 diagnostic criterias
(1) send out in neck, shoulder, the back of the body and extremity, not of uniform size, be flat agglomerate or lobulated; (2) poor growth, no conscious sympton, matter is soft and flexible, can have pseudofluctuation.
3 experimental techniques
Experimental formula is: Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g.Its decocting method is: S1: by Concha Meretricis seu Cyclinae and Concha Arcae, after mixing, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material, decoct subsequently 0.5～1 hour, S2: Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are mixed, add the water of 6～8 times of amounts of medical material; S3: the medicinal liquid of S1 step and medicinal residues are mixed to the rear common 15～20min of decoction with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use; S4: add the decocting of 6～8 times of medical material amounts to boil 15～20min the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard.Instructions of taking: take 1 dose every day, every bu is taken for 3 times 3 months is 1 course for the treatment of.After taking 1 course for the treatment of, add up curative effect.
4 the standard of curative effect evaluations
Cure: the atrophy of tumor body, approach normally, simultaneous phenomenon disappears or substantially disappears;
Effective: tumor body obviously dwindles, and simultaneous phenomenon obviously alleviates;
Effective: tumor body and simultaneous phenomenon all alleviate before treatment;
Invalid: tumorous size, number do not change.
5 results
52 routine patients after 1 course for the treatment of drug treatment, recovery from illness 27 examples (51.92%), effective 13 examples (25%), effective 9 examples (17.31%), invalid 3 examples (5.77%), total effective rate reaches 94.23%.Experiment finishes rear each patient to be carried out to electrocardiogram, liver, the inspection of kidney merit safety indexes, each patient's electrocardiogram, liver, kidney merit no abnormality seen.
Claims (10)
1. the lipomatous pharmaceutical composition for the treatment of, is characterized in that: it is made up of the raw material of following ratio of weight and number: 15～60 parts, Poria, 10～50 parts of Spica Prunellaes, 10～50 parts of Fructus Forsythiaes, 10～50 parts of Semen Sinapis Albaes, 10～50 parts of Bulbus Fritillariae Thunbergiis, 10～50 parts of Concha Meretricis seu Cyclinaes, 10～50 parts of Concha Arcaes, 10～50 parts of Rhizoma Curcumae, 10～50 parts of Caulis Bambusae In Taenia, 10～50 parts of Fructus Aurantii Immaturuss, 5～40 parts of Rhizoma Pinelliae Preparatum, 5～40 parts of Pericarpium Citri Reticulataes, 1～10 part, Radix Glycyrrhizae.
2. one according to claim 1 is treated lipomatous pharmaceutical composition, it is characterized in that: the ratio of weight and number of described each raw material is: 20～50 parts, Poria, 15～40 parts of Spica Prunellaes, 15～40 parts of Fructus Forsythiaes, 15～40 parts of Semen Sinapis Albaes, 15～40 parts of Bulbus Fritillariae Thunbergiis, 15～40 parts of Concha Meretricis seu Cyclinaes, 15～40 parts of Concha Arcaes, 15～40 parts of Rhizoma Curcumae, 15～40 parts of Caulis Bambusae In Taenia, 15～40 parts of Fructus Aurantii Immaturuss, 10～30 parts of Rhizoma Pinelliae Preparatum, 10～30 parts of Pericarpium Citri Reticulataes, 3～8 parts, Radix Glycyrrhizae.
3. one according to claim 1 is treated lipomatous pharmaceutical composition, it is characterized in that: the ratio of weight and number of described each raw material is: 25～40 parts, Poria, 20～35 parts of Spica Prunellaes, 20～35 parts of Fructus Forsythiaes, 20～35 parts of Semen Sinapis Albaes, 20～35 parts of Bulbus Fritillariae Thunbergiis, 20～35 parts of Concha Meretricis seu Cyclinaes, 20～35 parts of Concha Arcaes, 20～35 parts of Rhizoma Curcumae, 20～35 parts of Caulis Bambusae In Taenia, 20～35 parts of Fructus Aurantii Immaturuss, 15～25 parts of Rhizoma Pinelliae Preparatum, 15～25 parts of Pericarpium Citri Reticulataes, 4～6 parts, Radix Glycyrrhizae.
4. one according to claim 1 is treated lipomatous pharmaceutical composition, it is characterized in that: the ratio of weight and number of described each raw material is: 30 parts, Poria, 25 parts of Spica Prunellaes, 25 parts of Fructus Forsythiaes, 25 parts of Semen Sinapis Albaes, 25 parts of Bulbus Fritillariae Thunbergiis, 25 parts of Concha Meretricis seu Cyclinaes, 25 parts of Concha Arcaes, 25 parts of Rhizoma Curcumae, 25 parts of Caulis Bambusae In Taenia, 25 parts of Fructus Aurantii Immaturuss, 20 parts of Rhizoma Pinelliae Preparatum, 20 parts of Pericarpium Citri Reticulataes, 5 parts, Radix Glycyrrhizae.
5. one according to claim 1 is treated lipomatous pharmaceutical composition, it is characterized in that: the ratio of weight and number of described each raw material is: 20 parts, Poria, 15 parts of Spica Prunellaes, 15 parts of Fructus Forsythiaes, 15 parts of Semen Sinapis Albaes, 15 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Concha Meretricis seu Cyclinaes, 15 parts of Concha Arcaes, 15 parts of Rhizoma Curcumae, 15 parts of Caulis Bambusae In Taenia, 15 parts of Fructus Aurantii Immaturuss, 12 parts of Rhizoma Pinelliae Preparatum, 12 parts of Pericarpium Citri Reticulataes, 3 parts, Radix Glycyrrhizae.
6. a method of preparing the lipomatous pharmaceutical composition for the treatment of described in any one in claim 1～5, is characterized in that: it comprises the following steps:
S1: take by weight Concha Meretricis seu Cyclinae and Concha Arcae, add the water soaking 0.5～1 hour of 6～8 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour;
S2: take by weight Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae and mix, add the water of 6～8 times of amounts of medical material;
S3: the medicinal liquid of S1 step and medicinal residues are mixed to rear common decoction 1～1.5 hour with the medical material of S2 step, filter and obtain decocting liquid, medicinal residues are for subsequent use;
S4: add the decocting of 6～8 times of medical material amounts to boil 1～1.5 hour the medicinal residues in S3 step again, filter and obtain decocting liquid, medicinal residues discard;
S5: after the decocting liquid in the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
7. a kind of preparation method for the treatment of lipomatous pharmaceutical composition according to claim 6, is characterized in that: described pharmaceutical preparation is tablet, capsule, granule, powder or oral liquid.
8. a kind of preparation method for the treatment of lipomatous pharmaceutical composition according to claim 6, is characterized in that: described pharmaceutically acceptable adjuvant comprises starch, magnesium stearate, dextrin and microcrystalline Cellulose.
9. the application of the pharmaceutical composition as described in any one claim in claim 1～5 in preparation treatment lipoma medicine.
10. application according to claim 9, is characterized in that: described lipoma is subcutaneous fat tumor.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491707A (en) * | 2014-12-10 | 2015-04-08 | 马建国 | Ointment for treating lipomyoma and preparation method for ointment |
| CN105214000A (en) * | 2015-11-09 | 2016-01-06 | 陈慧珊 | A kind of Chinese medicine oral liquid and preparation method for the treatment of subcutaneous fat tumor |
| CN107362296A (en) * | 2017-06-14 | 2017-11-21 | 河南省中医院（河南中医学院第二附属医院） | Medicine for treating benign tumor of skin and preparation method thereof |
| CN108114240A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Treat lipomatous Chinese medicine composition and its preparation method and application |
-
2014
- 2014-02-27 CN CN201410068476.9A patent/CN103830674B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 孙冬红: "中医药治疗脂肪瘤近况", 《南京中医药大学学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491707A (en) * | 2014-12-10 | 2015-04-08 | 马建国 | Ointment for treating lipomyoma and preparation method for ointment |
| CN105214000A (en) * | 2015-11-09 | 2016-01-06 | 陈慧珊 | A kind of Chinese medicine oral liquid and preparation method for the treatment of subcutaneous fat tumor |
| CN107362296A (en) * | 2017-06-14 | 2017-11-21 | 河南省中医院（河南中医学院第二附属医院） | Medicine for treating benign tumor of skin and preparation method thereof |
| CN107362296B (en) * | 2017-06-14 | 2020-12-04 | 河南省中医院（河南中医学院第二附属医院） | Medicine for treating benign tumor of skin and preparation method thereof |
| CN108114240A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Treat lipomatous Chinese medicine composition and its preparation method and application |
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|---|---|
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