CN101954022B - Chinese medicinal composition for treating lung cancer - Google Patents
Chinese medicinal composition for treating lung cancer Download PDFInfo
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- CN101954022B CN101954022B CN2010105070996A CN201010507099A CN101954022B CN 101954022 B CN101954022 B CN 101954022B CN 2010105070996 A CN2010105070996 A CN 2010105070996A CN 201010507099 A CN201010507099 A CN 201010507099A CN 101954022 B CN101954022 B CN 101954022B
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal composition for treating lung cancer. The composition consists of an active ingredient or the active ingredient and a pharmaceutically acceptable carrier. The active ingredient is prepared from the following pharmaceutical ingredients: adenophora, asparagus root, dwarf lilyturf tuber, shizandra berry, American ginseng, unibract fritillary bulb, loquat leaves, barbed skullcap herb, astragalus, scorch-fried three immortals, powdered notoginseng root, arisaema cum bile, pinellia tuber, bamboo shavings, patrinia heterophylla Bge., bittersweet herb, common hongfennel root, Chinese paris rhizome and redroot gromwell root. The Chinese medicinal composition of the invention has the effect of clearing heat and resolving toxin, and eliminating blood stasis and detoxicating, is used for surgery and treatment after radiation treatment for lung cancer caused by accumulated toxin and blood-stasis obstruction, has no toxic or side effects, has an obvious treatment effect and a total effective rate of more than 95.0 percent, and is an ideal medicament for treating lung cancer.
Description
[technical field]
The invention belongs to the Chinese medicine technical field of pharmaceuticals.More specifically, the present invention relates to a kind of Chinese medicine composition that is used to treat pulmonary carcinoma.
[background technology]
Pulmonary carcinoma is a kind of common pulmonary malignant tumour, and its mortality rate is very high.Along with industrial construction is fast-developing; People's living environment is seriously influenced, and adds bad life habits such as smoking, and countries in the world are industrially developed country particularly; Lung cancer morbidity rate and case fatality rate are in rapid rising, and lung cancer mortality has occupied first of the various cancer mortalities.
Pulmonary carcinoma makes bronchial wall extend expansion in growth course on the one hand, and forms lump through the contiguous lung tissue of bronchial wall intrusion, invades simultaneously and causes its luminal stenosis or obstruction in the bronchus.This cancer further can be invaded contiguous organ pipe tissue such as thoracic wall, mediastinum, heart, trunk from the lung direct extension; Transfer to other positions of health through lymphatic channel blood road.The speed of growth of cancerous protuberance with shift biological characteristicses such as histological type that diffusion path depends on cancerous protuberance, differentiation degree.Ministry of Health of the People's Republic of China formulates in " new Chinese medicine treatment primary bronchogenic carcinoma of lung clinical research guideline " pulmonary carcinoma is divided into five kinds of pattern of syndrome: 1. qi-asthenia phlegm damp syndrome; 2. syndrome of endogenous heat due to yin deficiency; 3. syndrome of deficiency of both qi and yin; 4. syndrome of qi stagnation and blood stasis; 5. excessive noxious heat is demonstrate,proved.Because of pulmonary carcinoma early symptom concealment,, clinically accumulate with the deficiency of both QI and YIN expectorant heat of holding concurrently that the lung card more to be seen in case find just to get into the cancer middle and advanced stage.The method of treatment pulmonary carcinoma has operation, radiotherapy, chemotherapy and Drug therapy or above-mentioned several different methods partner treatment.
At present, the vast medical worker of China actively excavates abundant motherland's medical science resource, has carried out big quantity research for solving treatment pulmonary carcinoma.
CN 95101030 discloses a kind of Chinese medicine composition and preparation method thereof.Said composition comprises Moschus, Calculus Bovis, Margarita, Bufo siccus, Rhizoma Dysosmae Versipellis, Herba Menthae, Borneolum Syntheticum, Flos Daturae and Flos Farfarae composition, with the smoked suction administration through the patient respiration road of fumicants form.CN 01118917 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma, according to monarch, minister, help, make principles of formulating prescriptions compatibility.Monarch drug is a Cordyceps; Ministerial drug comprises Radix Adenophorae, Radix Glehniae, Bulbus Lilii; Adjuvant drug comprises Fructus Polygoni Orientalis, Herba Taraxaci, Herba Hedyotidis Diffusae, Carapax Trionycis, Radix Notoginseng; Messenger drug is a Fructus Trichosanthis.CN 02146653 discloses a kind of Chinese medicine composition of treating tumor, and this Chinese medicine composition comprises Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng, Cordyceps, Rhizoma Chuanxiong, ground beetle, Squama Manis, Rhizoma Arisaematis and Moschus.CN 200310122425 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma and preparation method thereof.Said composition is made up of Radix Et Rhizoma Rhei, Semen Impatientis, Hirudo, Scorpio, Scolopendra, Herba Asari, Concha Ostreae, Fructus Trichosanthis, Radix Ginseng, Fructus Psoraleae, Bungarus Parvus.The effect that said composition treatment pulmonary carcinoma has good restraining tumor growth, metastasis, raise immunity.CN 200610020566 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma, esophageal carcinoma, laryngocarcinoma, this Chinese medicine composition by Radix Ginseng, Rhizoma Pinelliae Preparata, Bulbus Fritillariae Cirrhosae, Arisaema Cum Bile, Fructus Aurantii Immaturus, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Adenophorae (Radix Glehniae), Radix Scrophulariae, Poria, Semen Armeniacae Amarum, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Radix Rehmanniae, Radix Polygoni Multiflori, Fructus Amomi, KOUREN, fragrantly pay, Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Glycyrrhizae, Herba Portulacae Grandiflorae, Herba Hedyotidis Diffusae, Caulis Bambusae In Taenia form.CN 200710015686 discloses a kind of Chinese medicine composition of orally taken for curing pulmonary carcinoma, and this Chinese medicine composition is made up of Herba Houttuyniae, Bulbus Lilii, Pericarpium Trichosanthis, Folium Eriobotryae, living Semen Coicis, Radix Platycodonis, Radix Ophiopogonis, Cortex Lycii and Pericarpium Citri Reticulatae.This Chinese medicine composition has blood circulation promoting and blood stasis dispelling, the effect of dissipating phlegm and resolving masses, and determined curative effect, and instant effect, and have no side effect.CN 200710303703 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma, and it is mainly processed by Rhizoma Curcumae, Semen Lepidii (Semen Descurainiae), the Radix Astragali, Radix Adenophorae, Cortex Mori, Radix Platycodonis, Fructus Aurantii, the Rhizoma Pinelliae, Folium Perillae, dry maxima skin, Herba Ephedrae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae.CN 200810159997 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma and preparation method thereof, and this Chinese medicine composition is processed by Herba Taraxaci, Radix Glycyrrhizae, Radix Ginseng, Rhizoma Polygoni Cuspidati, Rhizoma Curcumae, Herba Houttuyniae, Sanguis Draxonis, Indigo Naturalis, Herba Asari, Rhizoma Polygonati, Fructus Lycii.CN 200810056323 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma and preparation method thereof, and this Chinese medicine composition is processed by Herba Hedyotidis Diffusae, Herba Taraxaci, Margarita, Moschus, Sanguis Draxonis, Radix Ginseng, Calculus Bovis, Borneolum Syntheticum, Rhizoma Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Herb Gynostemmae Pentaphylli, Nidus Vespae.CN 200810138918 discloses a kind of Chinese medicine composition of treating pulmonary carcinoma, and this Chinese medicine composition is processed by Radix Panacis Quinquefolii, Endothelium Corneum Gigeriae Galli, Radix Notoginseng, Rhizoma Cyperi, Semen Coicis.
Patent application document by these treatment by Chinese herbs pulmonary carcinoma can be found out; The vast medical worker of China is obtaining very gratifying achievement aspect motherland's medical science resource treatment pulmonary carcinoma that excavation is enriched; Bring into play enormous function, but also had some improved places that need keep punching.
For this reason, the inventor has accomplished the present invention finally through long-term a large amount of experimental studies.
[summary of the invention]
[technical problem that will solve]
The purpose of this invention is to provide a kind of Chinese medicine composition that is used to treat pulmonary carcinoma.
[technical scheme]
The present invention realizes through following technical proposals.
The present invention relates to a kind of Chinese medicine composition that is used to treat pulmonary carcinoma.
Treatment pulmonary carcinoma Chinese medicine composition of the present invention is formed by effective ingredient or effective ingredient and at pharmaceutically acceptable carrier, it is characterized in that described effective ingredient processed by following raw material medicaments:
Radix Adenophorae (Radix Glehniae) 20-40 weight portion Radix Asparagi 10-20 weight portion
Radix Ophiopogonis 10-20 weight portion Fructus Schisandrae Chinensis 8-12 weight portion
Radix Panacis Quinquefolii 8-12 weight portion Bulbus Fritillariae Cirrhosae 8-12 weight portion
Folium Eriobotryae 10-20 weight portion Herba Scutellariae Barbatae 10-20 weight portion
Radix Astragali 20-40 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 20-40 weight portion
Radix Notoginseng powder 4-8 weight portion Arisaema Cum Bile 10-20 weight portion
Rhizoma Pinelliae 8-12 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10-14 weight portion
Radix Patriniae heterophyllae 20-40 weight portion Herba Solani Lyrati 20-40 weight portion
Radix Peucedani 10-20 weight portion Rhizoma Paridis 10-20 weight portion
Radix Arnebiae (Radix Lithospermi) 8-12 weight portion.
A preferred embodiment of the invention, described effective ingredient is processed by following raw material medicaments:
Radix Adenophorae (Radix Glehniae) 25-35 weight portion Radix Asparagi 12-18 weight portion
Radix Ophiopogonis 12-18 weight portion Fructus Schisandrae Chinensis 9-11 weight portion
Radix Panacis Quinquefolii 9-11 weight portion Bulbus Fritillariae Cirrhosae 9-11 weight portion
Folium Eriobotryae 12-18 weight portion Herba Scutellariae Barbatae 12-18 weight portion
Radix Astragali 25-35 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 25-35 weight portion
Radix Notoginseng powder 5-7 weight portion Arisaema Cum Bile 12-18 weight portion
Rhizoma Pinelliae 9-11 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 11-13 weight portion
Radix Patriniae heterophyllae 25-35 weight portion Herba Solani Lyrati 25-35 weight portion
Radix Peucedani 12-18 weight portion Rhizoma Paridis 12-18 weight portion
Radix Arnebiae (Radix Lithospermi) 9-11 weight portion.
According to another kind of preferred implementation of the present invention, it is characterized in that described effective ingredient processed by following raw material medicaments:
Radix Adenophorae (Radix Glehniae) 30 weight portion Radix Asparagis 15 weight portions
Radix Ophiopogonis 15 weight portion Fructus Schisandrae Chinensis, 10 weight portions
Radix Panacis Quinquefolii 10 weight portion Bulbus Fritillariae Cirrhosaes 10 weight portions
Folium Eriobotryae 15 weight portion Herba Scutellariae Barbataes 15 weight portions
The Radix Astragali 30 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 30 weight portions
Radix Notoginseng powder 6 weight portion Arisaema Cum Bile 15 weight portions
The Rhizoma Pinelliae 10 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 12 weight portions
Radix Patriniae heterophyllae 30 weight portion Herba Solani Lyratis 30 weight portions
Radix Peucedani 15 weight portion Rhizoma Paridis 15 weight portions
Radix Arnebiae (Radix Lithospermi) 10 weight portions.
According to another kind of preferred implementation of the present invention, it is granule, capsule, tablet, pill or oral liquid that the present invention treats the pulmonary carcinoma Chinese medicine composition.
According to another kind of preferred implementation of the present invention, be that one or more are selected from the carrier of normally used filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant or correctives pharmaceutically at pharmaceutically acceptable carrier.
According to another kind of preferred implementation of the present invention, described filler is selected from starch, sucrose, lactose or microcrystalline Cellulose.
According to another kind of preferred implementation of the present invention, described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone.
According to another kind of preferred implementation of the present invention, described disintegrating agent is selected from carboxymethyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate or sodium bicarbonate.
According to another kind of preferred implementation of the present invention, described surfactant is hexadecanol or sodium lauryl sulphate.
According to another kind of preferred implementation of the present invention, described lubricant is selected from Pulvis Talci, calcium stearate and magnesium, micropowder silica gel or Polyethylene Glycol.
Below the present invention will be described in more detail.
The present invention relates to a kind of Chinese medicine composition that is used to treat pulmonary carcinoma.Said Chinese medicine composition is formed by effective ingredient or effective ingredient and at pharmaceutically acceptable carrier, it is characterized in that described effective ingredient processed by following raw material medicaments:
Radix Adenophorae (Radix Glehniae) 20-40 weight portion Radix Asparagi 10-20 weight portion
Radix Ophiopogonis 10-20 weight portion Fructus Schisandrae Chinensis 8-12 weight portion
Radix Panacis Quinquefolii 8-12 weight portion Bulbus Fritillariae Cirrhosae 8-12 weight portion
Folium Eriobotryae 10-20 weight portion Herba Scutellariae Barbatae 10-20 weight portion
Radix Astragali 20-40 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 20-40 weight portion
Radix Notoginseng powder 4-8 weight portion Arisaema Cum Bile 10-20 weight portion
Rhizoma Pinelliae 8-12 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10-14 weight portion
Radix Patriniae heterophyllae 20-40 weight portion Herba Solani Lyrati 20-40 weight portion
Radix Peucedani 10-20 weight portion Rhizoma Paridis 10-20 weight portion
Radix Arnebiae (Radix Lithospermi) 8-12 weight portion.
Described effective ingredient should be appreciated that be that every flavor Chinese crude drug contains in the drug composition in the present invention the treatment cervical spondylotic radiculopathy is had the composition of active treatment effect.
The source and the pharmacological action of every flavor Chinese crude drug of mentioning in the drug composition in the present invention are following.
Radix Adenophorae (Radix Glehniae) is the dry root of campanulaceae plant adenophora tetraphylla Adenophora tetraphylla Thunb.Fisch. or Radix Adenophorae (Radix Glehniae) Adenophora stricta Miq..Nature and flavor are sweet, cold, and function cures mainly clearing away heat and nourishing YIN, nourishing the lung to arrest cough.Cure mainly tracheitis, pertussis, the cough due to lung-heat, it is yellow thick to cough up phlegm.
Radix Asparagi is the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Nature and flavor are sweet, bitter, and are cold.Return lung, kidney channel.Function with cure mainly nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.Be used for dryness of the lung dry cough, pertussis expectorant is sticking, dry throat and mouth, dryness of the intestine constipation.
Be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl. Radix Ophiopogonis.Nature and flavor are sweet, and little hardship is slightly cold.GUIXIN, lung, stomach warp.Function cures mainly YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.Be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra.The nature and flavor temperature; Sour, sweet; Return lung, the heart, kidney channel, function with cure mainly the convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L..Sweet, the little hardship of nature and flavor, cold.GUIXIN, lung, kidney channel.Function cures mainly boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.It is thanks to cloudy to be used for the deficiency of vital energy, interior-heat, and cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst dryness of the mouth and throat.
Bulbus Fritillariae Cirrhosae is the dry bulb of liliaceous plant Bulbus Fritillariae Cirrhosae Fritillaria cirrhosa D.Don, dark violet Bulbus Fritillariae Uninbracteatae Fritillaria unibracteata Hsiao et K.C.Hsia, Gansu Bulbus Fritillariae Uninbracteatae Fritillaria przewalskii Maxim. or Bulbus Fritillariae cirrhosae Fritillaria delavayi Franch..Nature and flavor are bitter, sweet, are slightly cold.Return lung, heart channel.Function cures mainly clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Folium Eriobotryae is the dried leaves of rosaceous plant Folium Eriobotryae Eriobotrya japonica (Thunb.) Lindl..Nature and flavor are bitter, are slightly cold.Attach to the lung and stomach meridians.Function cures mainly clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Be used for the cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, the gastric heat vomiting, dysphoria with smothery sensation is thirsty.
Herba Scutellariae Barbatae is the dry herb of labiate Herba Scutellariae Barbatae Scutellaria barbata D.Don.Nature and flavor are hot, bitter, and are cold.Return lung, liver, kidney channel.Function cures mainly heat-clearing and toxic substances removing, the blood stasis dispelling diuresis.Be used for furuncle swelling toxin, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, edema, jaundice.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor are sweet, temperature.Return lung, spleen channel.Function cures mainly invigorating QI to consolidate the body surface resistance, diuresis expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is three flavor medicine, i.e. Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown).Fructus Hordei Germinatus (parched to brown) has the effect of good digestible starch group food; Fructus Crataegi (parched to brown) is good at treating meat or greasy dyspepsia due to too much; Massa Medicata Fermentata (parched to brown) then is beneficial to digestion rice and flour food.Three medicines share, and can strengthen digestive function significantly.Therefore, the doctor often share three medicines and is called " JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) " clinically.
Radix Notoginseng is the root of panax araliaceae plant, nature and flavor temperature, sweet in the mouth, little hardship.Function cures mainly dissipating blood stasis hemostasis, subduing swelling and relieving pain.It is used for various inside and outside hemorrhage, breast ventral spine pains, tumbling and swelling.
Arisaema Cum Bile is that fine powder and cattle, sheep or the Fel Sus domestica of Rhizoma Arisaematis (processed) processes from strand, or processes through fermentation for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.Nature and flavor are bitter, little suffering, cold.Return lung, liver, spleen channel.Function with cure mainly removing heat-phlegm, dispelling wind and relieving convulsion.Be used for phlegm-heat cough, it is yellow thick to cough up phlegm, middle wind-phlegm fan, demented infantile convulsion.
The Rhizoma Pinelliae is the dry tuber of aroid Rhizoma Pinelliae Pinellia ternata (Thunb.) Breit..Nature and flavor are hot, temperature; Poisonous.Return spleen, stomach, lung meridian.Function with cure mainly drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Be used for the abundant expectoration cough with asthma, the phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, the syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus disease; Give birth to external treatment carbuncle sucutaneous nodule.
Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) is to fry to yellow person after Caulis Bambusae In Taenia is mixed thoroughly with Sucus Zingberis again.The nature and flavor cold nature, sweet in the mouth.Function cures mainly removing heat-phlegm, relieves restlessness and prevents vomiting.Be used for phlegm-heat cough, gallbladder fire and hold expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm.
Radix Patriniae heterophyllae is root or the herb of Valerianaceae Patrinia plant Radix Patriniae Scabrae Patrinia heterophylla Bunge and Radix Patriniae Scabrae P.scabra Bunge.Nature and flavor are bitter, little acid, puckery, cold.Function cures mainly heat clearing and damp drying, hemostasis, leukorrhagia stopping, preventing the attack (or recurrence) of malaria.Be used for uterine erosion, early cervical carcinoma, leucorrhea, metrorrhagia, malaria.
Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Meridian distribution of property and flavor: hardship is slightly cold.Go into liver, stomach warp.Slightly poisonous.Function cures mainly heat-clearing and toxic substances removing, and is inducing diuresis and reducing edema, anticancer.Herb: be used for cold, fever, acute mastitis, malignant boil, jaundice due to damp-heat, ascites, leucorrhea, oedema due to nephritis; Carbuncle furuncle and phyma poison is controlled in external.Root: rheumatic arthralgia.Antitumor action is arranged, and staphylococcus aureus, bacillus pyocyaneus are had tangible bacteriostasis.
Radix Peucedani is the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peuc-edanum decursivum Maxim..Nature and flavor are bitter, hot, are slightly cold.Return lung meridian.Function with cure mainly the wind heat clearing away of loosing, lowering the adverse-rising QI to resolve phlegm.Be used for cough due to pathogenic wind-heat's abundant expectoration, the expectorant dyspnea of heat type is full, and it is yellow thick to cough up phlegm.
Rhizoma Paridis is a liliaceous plant Rhizoma Paridis ParisyunnanensisFranch. rhizome.Meridian distribution of property and flavor: be slightly cold; Bitter; Return Liver Channel, function cures mainly heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Be used for the furuncle carbuncle, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, convulsion with spasms.
Radix Arnebiae (Radix Lithospermi) is the dry root of comfrey lithospermum euchromum Royle Arnebia euchroma (Royle) Johnst., Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb.et Zucc. or arnebia guttata Bunge Arnebia guttata Bunge.Sweet, the one-tenth of nature and flavor, cold.GUIXIN, Liver Channel.Function cures mainly removing heat from blood, invigorates blood circulation the detoxifcation rash.Be used for the heat in blood poison and contain, macule is purple black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Preferably, described effective ingredient is processed by following raw material medicaments:
Radix Adenophorae (Radix Glehniae) 25-35 weight portion Radix Asparagi 12-18 weight portion
Radix Ophiopogonis 12-18 weight portion Fructus Schisandrae Chinensis 9-11 weight portion
Radix Panacis Quinquefolii 9-11 weight portion Bulbus Fritillariae Cirrhosae 9-11 weight portion
Folium Eriobotryae 12-18 weight portion Herba Scutellariae Barbatae 12-18 weight portion
Radix Astragali 25-35 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 25-35 weight portion
Radix Notoginseng powder 5-7 weight portion Arisaema Cum Bile 12-18 weight portion
Rhizoma Pinelliae 9-11 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 11-13 weight portion
Radix Patriniae heterophyllae 25-35 weight portion Herba Solani Lyrati 25-35 weight portion
Radix Peucedani 12-18 weight portion Rhizoma Paridis 12-18 weight portion
Radix Arnebiae (Radix Lithospermi) 9-11 weight portion.
More preferably, described effective ingredient is processed by following raw material medicaments:
Radix Adenophorae (Radix Glehniae) 30 weight portion Radix Asparagis 15 weight portions
Radix Ophiopogonis 15 weight portion Fructus Schisandrae Chinensis, 10 weight portions
Radix Panacis Quinquefolii 10 weight portion Bulbus Fritillariae Cirrhosaes 10 weight portions
Folium Eriobotryae 15 weight portion Herba Scutellariae Barbataes 15 weight portions
The Radix Astragali 30 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 30 weight portions
Radix Notoginseng powder 6 weight portion Arisaema Cum Bile 15 weight portions
The Rhizoma Pinelliae 10 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 12 weight portions
Radix Patriniae heterophyllae 30 weight portion Herba Solani Lyratis 30 weight portions
Radix Peucedani 15 weight portion Rhizoma Paridis 15 weight portions
Radix Arnebiae (Radix Lithospermi) 10 weight portions.
The method that the present composition can adopt the technical staff in present technique field to know is processed granule, capsule, tablet, pill or oral liquid.
The decocting for Chinese herbal medicine method that for example can adopt usually according to the ratio 1 of Chinese crude drug weight with water weight: 2-4 decocte with water in the former medicine of above-mentioned Chinese medicine, filters, and the residue medicinal residues repeat 2-3 time again, and the filtrating of merging can be taken;
The filtrating that perhaps merges is carried out concentrating under reduced pressure again and is become paste under pressure 0.1-1.0MPa; The equipment that said concentrating under reduced pressure uses is normally used equipment in this medical technical field, for example the vacuum decompressioning and concentrating tank of Wuxi City Haidah chemical machinery company limited production.
Then, the fine powder that the drying under reduced pressure that under pressure 0.01-0.5MPa, carries out again obtains.The equipment that described drying under reduced pressure uses is normally used equipment in this medical technical field, for example the vacuum drying oven of the grand industry in Tianjin light industry and machinery company limited production.The fine powder that obtains can with process various dosage forms at pharmaceutically acceptable carrier or excipient composition; For example granule, capsule, tablet, pill or oral liquid; Wherein can select according to different dosage form at pharmaceutically acceptable carrier or excipient; Employed these carriers or excipient all are to confirm easily for the those of ordinary skill in pharmaceutical technology field, also are conspicuous.
According to the present invention, should be meant the conventional medicine carrier in pharmaceutical field at pharmaceutically acceptable carrier, for example diluent, excipient and water etc., filler such as starch, sucrose, lactose, microcrystalline Cellulose etc.; Binding agent such as cellulose derivative, alginate, gelatin and polyvinylpyrrolidone; Wetting agent such as glycerol; Disintegrating agent such as carboxymethyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate and sodium bicarbonate; Absorption enhancer such as quaternary ammonium compound; Surfactant such as hexadecanol, sodium lauryl sulphate; Absorption carrier such as kaolin and soap clay; Lubricant such as Pulvis Talci, calcium stearate and magnesium, micropowder silica gel and Polyethylene Glycol; Other adjuvant such as flavouring agent, sweeting agent etc.
[beneficial effect]
The present composition has the effect of strengthening the body resistance, regulating the flow of QI to dissipate blood stasis, expectorant powder junction, relieving cough and asthma, and determined curative effect, and the total effective rate of treatment pulmonary carcinoma reaches more than 95.0%, instant effect, and have no side effect, be applicable to treatment pulmonary carcinoma.
[specific embodiment]
Embodiment 1: the preparation of granule of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 3 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 2 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.5MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.05MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 30 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 20 weight portion Radix Asparagis 10 weight portions
Radix Ophiopogonis 20 weight portion Fructus Schisandrae Chinensis, 12 weight portions
Radix Panacis Quinquefolii 8 weight portion Bulbus Fritillariae Cirrhosaes 8 weight portions
Folium Eriobotryae 20 weight portion Herba Scutellariae Barbataes 20 weight portions
The Radix Astragali 20 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 20 weight portions
Radix Notoginseng powder 8 weight portion Arisaema Cum Bile 20 weight portions
The Rhizoma Pinelliae 8 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10 weight portions
Radix Patriniae heterophyllae 40 weight portion Herba Solani Lyratis 40 weight portions
Radix Peucedani 10 weight portion Rhizoma Paridis 10 weight portions
Radix Arnebiae (Radix Lithospermi) 12 weight portions.
Embodiment 2: the preparation of granule of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 2 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 3 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.4MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.06MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 30 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 40 weight portion Radix Asparagis 20 weight portions
Radix Ophiopogonis 10 weight portion Fructus Schisandrae Chinensis, 8 weight portions
Radix Panacis Quinquefolii 12 weight portion Bulbus Fritillariae Cirrhosaes 12 weight portions
Folium Eriobotryae 10 weight portion Herba Scutellariae Barbataes 10 weight portions
The Radix Astragali 40 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 40 weight portions
Radix Notoginseng powder 4 weight portion Arisaema Cum Bile 10 weight portions
The Rhizoma Pinelliae 12 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 14 weight portions
Radix Patriniae heterophyllae 20 weight portion Herba Solani Lyratis 20 weight portions
Radix Peucedani 20 weight portion Rhizoma Paridis 20 weight portions
Radix Arnebiae (Radix Lithospermi) 8 weight portions.
Embodiment 3: the preparation of granule of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 4 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 2 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.6MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.08MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 32 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 30 weight portion Radix Asparagis 15 weight portions
Radix Ophiopogonis 15 weight portion Fructus Schisandrae Chinensis, 10 weight portions
Radix Panacis Quinquefolii 10 weight portion Bulbus Fritillariae Cirrhosaes 10 weight portions
Folium Eriobotryae 15 weight portion Herba Scutellariae Barbataes 15 weight portions
The Radix Astragali 30 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 30 weight portions
Radix Notoginseng powder 6 weight portion Arisaema Cum Bile 15 weight portions
The Rhizoma Pinelliae 10 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 12 weight portions
Radix Patriniae heterophyllae 30 weight portion Herba Solani Lyratis 30 weight portions
Radix Peucedani 15 weight portion Rhizoma Paridis 15 weight portions
Radix Arnebiae (Radix Lithospermi) 10 weight portions.
Embodiment 4: the preparation of capsule of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 3 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 2 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.5MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.05MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 30 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 28 weight portion Radix Asparagis 12 weight portions
Radix Ophiopogonis 12 weight portion Fructus Schisandrae Chinensis, 11 weight portions
Radix Panacis Quinquefolii 11 weight portion Bulbus Fritillariae Cirrhosaes 11 weight portions
Folium Eriobotryae 12 weight portion Herba Scutellariae Barbataes 12 weight portions
The Radix Astragali 28 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 28 weight portions
Radix Notoginseng powder 7 weight portion Arisaema Cum Bile 12 weight portions
The Rhizoma Pinelliae 11 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 11 weight portions
Radix Patriniae heterophyllae 28 weight portion Herba Solani Lyratis 28 weight portions
Radix Peucedani 12 weight portion Rhizoma Paridis 12 weight portions
Radix Arnebiae (Radix Lithospermi) 11 weight portions.
The capsule that the fine powder for preparing is thus packed into then and sold in the market obtains capsule of the present invention.
Embodiment 5: the preparation of tablet of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 3 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 2 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.5MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.05MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 30 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 34 weight portion Radix Asparagis 18 weight portions
Radix Ophiopogonis 18 weight portion Fructus Schisandrae Chinensis, 8 weight portions
Radix Panacis Quinquefolii 8 weight portion Bulbus Fritillariae Cirrhosaes 8 weight portions
Folium Eriobotryae 18 weight portion Herba Scutellariae Barbataes 18 weight portions
The Radix Astragali 34 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 34 weight portions
Radix Notoginseng powder 4 weight portion Arisaema Cum Bile 18 weight portions
The Rhizoma Pinelliae 8 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 14 weight portions
Radix Patriniae heterophyllae 34 weight portion Herba Solani Lyratis 34 weight portions
Radix Peucedani 18 weight portion Rhizoma Paridis 18 weight portions
Radix Arnebiae (Radix Lithospermi) 8 weight portions.
The fine powder that obtains is thus processed wet granular with preparation tablet excipient starch commonly used again, tabletting then, and drying, packing obtains tablet of the present invention.
Embodiment 6: the preparation of pill of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 3 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 2 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.5MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.05MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 30 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 38 weight portion Radix Asparagis 14 weight portions
Radix Ophiopogonis 14 weight portion Fructus Schisandrae Chinensis, 9 weight portions
Radix Panacis Quinquefolii 9 weight portion Bulbus Fritillariae Cirrhosaes 9 weight portions
Folium Eriobotryae 14 weight portion Herba Scutellariae Barbataes 14 weight portions
The Radix Astragali 38 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 38 weight portions
Radix Notoginseng powder 5 weight portion Arisaema Cum Bile 14 weight portions
The Rhizoma Pinelliae 9 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10 weight portions
Radix Patriniae heterophyllae 38 weight portion Herba Solani Lyratis 38 weight portions
Radix Peucedani 14 weight portion Rhizoma Paridis 14 weight portions
Radix Arnebiae (Radix Lithospermi) 9 weight portions.
The fine powder that obtains thus adds refined honey again and processes pill of the present invention.
Embodiment 7: the preparation of oral liquid of the present invention
According to the ratio of Chinese crude drug weight and water weight 1: 3 decocte with water in the former medicine of following Chinese medicine; Filter; The residue medicinal residues repeat decocte with water 2 times again; The vacuum decompressioning and concentrating tank of the filtrating use Wuxi City Haidah chemical machinery company limited production that merges carries out concentrating under reduced pressure and becomes paste under pressure 0.5MPa, use the vacuum drying oven of Tianjin grand industry light industry and machinery company limited production under pressure 0.05MPa, to carry out drying under reduced pressure then, and fine powder reuse 75% ethanol that obtains is processed granule; Under 30 ℃ of temperature, carry out drying, packing.
Radix Adenophorae (Radix Glehniae) 24 weight portion Radix Asparagis 16 weight portions
Radix Ophiopogonis 16 weight portion Fructus Schisandrae Chinensis, 12 weight portions
Radix Panacis Quinquefolii 12 weight portion Bulbus Fritillariae Cirrhosaes 12 weight portions
Folium Eriobotryae 16 weight portion Herba Scutellariae Barbataes 16 weight portions
The Radix Astragali 24 weight portion JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s 24 weight portions
Radix Notoginseng powder 8 weight portion Arisaema Cum Bile 16 weight portions
The Rhizoma Pinelliae 12 weight portion Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 13 weight portions
Radix Patriniae heterophyllae 24 weight portion Herba Solani Lyratis 24 weight portions
Radix Peucedani 16 weight portion Rhizoma Paridis 16 weight portions
Radix Arnebiae (Radix Lithospermi) 12 weight portions.
The fine powder mixing that obtains thus adds correctives Mel and diluent water again and processes oral liquid of the present invention.
Below further specify the effect of Chinese medicine composition of the present invention through clinical trial.
Test Example 1:
Granule clinical trial case of the present invention is selected:
1, meets pulmonary cancer diagnosis standard and tcm syndrome diagnostic criteria and suitable radiotherapy person, can include case in.
2, experimenter muscle power situation is fair, estimation 3 months persons of surviving.
3, pulmonary carcinoma II phase, III phase and IV phase person.
4, the age is at 18-65 between year, non-gestation or women breast-feeding their children, non-allergic constitution.
Get rid of the case standard:
1, non-primary lung cancer, stopping of pulmonary carcinoma, two months patients of radiotherapy less than.
2, be associated with serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic.
Test method:
1, adopts randomized blocks
2, observe 43 examples
3, medication: use medicinal granule of the present invention, each 10 grams, every day 3 times, warm boiled water.
4, the course of treatment: 2 months is 1 course of treatment, 1 course of treatment of medication, does not use other treatment relevant with primary disease during the clinical verification.
Curative effect determinate standard:
1, produce effects: cardinal symptom is obviously improved or is disappeared, and focus is dwindled more than 1/2, and continues more than 1 month.
2, effective: cardinal symptom makes moderate progress or obviously improves, and focus is dwindled more than 1/3, and continues more than 1 month.
3, invalid: cardinal symptom does not have improvement or increases the weight of focus no change or development.
Result of the test: table 1: pulmonary carcinoma efficacy analysis table
Above-mentioned result of the test shows; Medicine of the present invention has the effect of heat-clearing and toxic substances removing, dissolving blood stasis and detoxication; Can be used for that malicious heresy is pented up, the pulmonary carcinoma operation due to the blood-stasis internal-depression and the treatment after the radiotherapy, and have no side effect, evident in efficacy; The total effective rate of treatment pulmonary carcinoma reaches more than 95.0%, is a kind of ideal treatment lung-cancer medicament.
Claims (9)
1. Chinese medicine composition that is used to treat pulmonary carcinoma, it is formed by effective ingredient or effective ingredient and at pharmaceutically acceptable carrier, it is characterized in that described effective ingredient processed by following raw material medicaments:
2. Chinese medicine composition according to claim 1 is characterized in that described effective ingredient processed by following raw material medicaments:
3. Chinese medicine composition according to claim 1 is characterized in that described effective ingredient processed by following raw material medicaments:
4. Chinese medicine composition according to claim 1 is characterized in that it is granule, capsule, tablet, pill or oral liquid.
5. Chinese medicine composition according to claim 1 is characterized in that at pharmaceutically acceptable carrier it being that one or more are selected from the carrier of normally used filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant or correctives pharmaceutically.
6. Chinese medicine composition according to claim 5 is characterized in that described filler is selected from starch, sucrose, lactose or microcrystalline Cellulose.
7. Chinese medicine composition according to claim 5 is characterized in that described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone.
8. Chinese medicine composition according to claim 5 is characterized in that described disintegrating agent is selected from carboxymethyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate or sodium bicarbonate.
9. Chinese medicine composition according to claim 5 is characterized in that described surfactant is hexadecanol or sodium lauryl sulphate.
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| CN103127433B (en) * | 2013-03-08 | 2014-09-24 | 陈印安 | Chinese medicament for treating lung cancer and preparation method thereof |
| CN106260990A (en) * | 2015-06-08 | 2017-01-04 | 杜乃龙 | A kind of diet therapy formula assisting treatment pulmonary carcinoma |
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| CN1555829A (en) * | 2003-12-30 | 2004-12-22 | 杨庆甲 | Chinese medicinal preparation for treating cancer |
| CN1857565A (en) * | 2006-03-23 | 2006-11-08 | 武汉理工大学 | Anticancer compound Chinese medicine powder and its preparing method |
| CN101757425A (en) * | 2008-11-21 | 2010-06-30 | 叶军 | Method for curing lung cancer by using tonifying Qi reinforcing lungs prescription |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1555829A (en) * | 2003-12-30 | 2004-12-22 | 杨庆甲 | Chinese medicinal preparation for treating cancer |
| CN1857565A (en) * | 2006-03-23 | 2006-11-08 | 武汉理工大学 | Anticancer compound Chinese medicine powder and its preparing method |
| CN101757425A (en) * | 2008-11-21 | 2010-06-30 | 叶军 | Method for curing lung cancer by using tonifying Qi reinforcing lungs prescription |
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| Title |
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| 南京中医药大学.墓头回、白毛藤.《中药大辞典》.上海世纪出版股份有限公司、上海科学技术出版社,2006,第3405、972页. * |
| 徐萌 等.沙参麦冬汤加减对非小细胞肺癌化疗增效减毒的临床研究.《新中医》.2006,第38卷(第4期),第29-30页. * |
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