CN104815148A

CN104815148A - Pharmaceutical composition for treating hyperplasia of mammary glands

Info

Publication number: CN104815148A
Application number: CN201510200338.6A
Authority: CN
Inventors: 吴联合
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-27
Filing date: 2015-04-27
Publication date: 2015-08-05
Anticipated expiration: 2035-04-27
Also published as: CN104815148B

Abstract

The invention discloses pharmaceutical composition for treating hyperplasia of mammary glands. The pharmaceutical composition for treating the hyperplasia of mammary glands includes 30 to 45 parts of whole okra, 30 to 45 parts of astragalus membranaceus, 20 to 30 parts of blood clam shell, 20 to 30 parts of nut grass galingale rhizome, 18 to 25 parts of Chinese angelica, 18 to 25 parts of seaweed, 10 to 15 parts of drynaria rhizome, 10 to 15 parts of Chinese thorowax root, 5 to 12 parts of epimedium herb, 5 to 12 parts of the seed of Chinese dodder, 3 to 8 parts of thunberg fritillary bulb, 3 to 8 parts of the root of red-rooted salvia, 3 to 8 parts of oryzanol and 3 to 8 parts of Chinese sage herb by weight. The pharmaceutical composition for treating the hyperplasia of mammary glands is exclusive in prescription, and the raw materials start effect synergistically; the pharmaceutical composition for treating the hyperplasia of mammary glands plays roles of soothing the liver, regulating qi, promoting blood flow, removing stasis, eliminating sputum and softening hard mass, is fast in effect for the hyperplasia of mammary glands, and is obvious in curative effect.

Description

A kind of pharmaceutical composition for the treatment of cyclomastopathy

Technical field

The present invention relates to a kind of compositions, be specifically related to a kind of pharmaceutical composition for the treatment of cyclomastopathy, belong to technical field of Chinese medicines.

Background technology

Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue.Be the modal cystic hyperplasia of breast of women, its pathogenic factor is mainly because endocrine hormone dyssecretosis is relevant with Nervous and Mental Factors.Traditional Chinese Medicine thinks that it is that Chinese medicine is referred to as " nodules of the breast " because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into caused by core, Chong and Ren channel disorder.Modern medicine is then thought, its generation, to develop and lapse to be that hormonal circadian change due in human female caused completely.Spirit is too nervous, emotion is too exciting, repeatedly artificial abortion, estrogen definitely or relatively increase, progestogen definitely or relatively reduce, long-term taking all may cause cyclomastopathy containing estrogenic health product, contraceptive etc.

The traditional Chinese medical science is thought, this sick pathogenic factor many with internal organs dysfunction, qi-blood disharmony relevant, women's sentimentality, one is unsatisfactory, and the fire of conscience is sprung into life, and Liver Channel lactogenesis follows row two side of body, causes stagnation of QI expectorant to coagulate in breast.So the traditional Chinese medical science generally adopts the method for soothing liver-QI for relieving depression, promoting the circulation of QI and reducing phlegm to treat.

Summary of the invention

The object of this invention is to provide a kind of pharmaceutical composition for the treatment of cyclomastopathy, said composition has effect of depressed liver-energy dispersing and QI regulating, blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses, can fast and effeciently prevention and therapy to cyclomastopathy.

The present invention is achieved by the following measures:

Treat a pharmaceutical composition for cyclomastopathy, it is characterized in that the crude drug comprising following weight portion: Abelmoschus esculentus Herb 30-45 part, Radix Astragali 30-45 part, Concha Arcae 20-30 part, Rhizoma Cyperi 20-30 part, Radix Angelicae Sinensis 18-25 part, Sargassum 18-25 part, Rhizoma Drynariae 10-15 part, Radix Bupleuri 10-15 part, Herba Epimedii 5-12 part, Semen Cuscutae 5-12 part, Bulbus Fritillariae Thunbergii 3-8 part, Radix Salviae Miltiorrhizae 3-8 part, oryzanol 3-8 part, Herba Salviae Chinensis 3-8 part.

Aforementioned pharmaceutical compositions preferably includes the crude drug of following weight portion: Abelmoschus esculentus Herb 35 parts, the Radix Astragali 35 parts, Concha Arcae 25 parts, Rhizoma Cyperi 25 parts, Radix Angelicae Sinensis 20 parts, Sargassum 20 parts, Rhizoma Drynariae 12 parts, Radix Bupleuri 12 parts, Herba Epimedii 10 parts, Semen Cuscutae 10 parts, Bulbus Fritillariae Thunbergii 5 parts, Radix Salviae Miltiorrhizae 5 parts, oryzanol 5 parts, Herba Salviae Chinensis 5 parts.

The selected 14 taste medical materials of the present invention are as crude drug, and all medicines share the effect with depressed liver-energy dispersing and QI regulating, blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses, and each crude drug effect is as follows:

Abelmoschus esculentus, another name Flos abelmoschi manihot (formal name used at school: Abelmoschus esculentus), Radix seu folium abelmoschi moschati, foreign eggplant, Cornu Caprae seu Ovis dish, swordweed, Cornu Caprae seu Ovis green pepper, foreign Fructus Capsici are the annual herbaceous plant of Malvaceae.Abelmoschus esculentus Herb comprises root, leaf and fruit pod, and it is rich in abundant vitamin and trace element, has the effect of clearing away heat-damp and promoting diuresis, the liver protecting, kidney tonifying tonify deficiency, resisting fatigue.

The Radix Astragali, the root of leguminous plant Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Nature and flavor are sweet, tepor, do not burst or burst the disease such as not hold back for a long time for spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle.

Concha Arcae, the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa and Scapharca subcrenata, has eliminating phlegm and softening indurated mass, blood stasis-eliminating and stagnation-dissipating, effect of relieving gastric hyperacidity to alleviate stomachache, cures mainly the long-pending knot of pertinacious phlegm, scrofula, goiter ， mass in the abdomen mass in the abdomen.

Rhizoma Cyperi, the dry rhizome of sedge dried tuber, has promoting QI circulation for relieving depression, effect of menstruction regulating and pain relieving, and for stagnation of QI due to depression of the liver, the breast side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Radix Angelicae Sinensis, the root of Umbelliferae Radix Angelicae Sinensis, has tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, effect of loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Sargassum, the dry frond of Sargassaceae plant Sargassum or Sargassum fusiforme (Harv.) Setch, has hard masses softening and resolving, expectorant, effect of diuretic, for goiter, scrofula, painful and swollen testis, phlegm retention edema.

Rhizoma Drynariae, has the kidney invigorating bone strengthening, and continuous effect of hindering pain relieving, for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone.

Radix Bupleuri, the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii., has reconciling superficies and interior, soothing the liver, effect of yang invigorating, for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Herba Epimedii, Berberidaceae plant Herba Epimedii ,epimedium sagittatum ,e. Pubescens ,the dry aerial parts of Epimedium wushanense or Herba Epimedii, have kidney-replenishing, bone and muscle strengthening, effect of wind-damp dispelling, and for impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture.

Semen Cuscutae, the seed of Convolvulaceae Semen Cuscutae, there is the kidney invigorating and essence nourishing, effect of nourishing the liver to improve visual acuity, the waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.

Bulbus Fritillariae Thunbergii, the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii, has heat clearing away eliminating stagnation, effect of preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.

Radix Salviae Miltiorrhizae, the dry root and rhizome of labiate Radix Salviae Miltiorrhizae, has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire, for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Oryzanol, has reduction blood fat, improves the effects such as vegetative nerve function, stabilizing the emotions, anxiety reduction, can be used for beauty treatment, be also usually used in the auxiliary treatment of premenstrual tension syndrome, climacteric syndrome.

Herba Salviae Chinensis, the herb of labiate Salvia chinensis, has effect of blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating, cures mainly menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, have blood in stool, rheumatic ostalgia, scrofula, and skin ulcer swells, acute mastitis etc.

Present composition preparation method is simple, by each crude drug mix homogeneously, is ground into 80-100 object fine powder.In order to taking convenience, conventional method can also be adopted to make capsule, tablets and other formulations.

Pharmaceutical composition of the present invention every day 3 times in use, count 3-6g with crude drug at every turn.

Formula of the present invention is unique, and each crude drug works in coordination with onset, has the effect of depressed liver-energy dispersing and QI regulating, blood circulation promoting and dispersing pathogen accumulation, resolving phlegm and softening hard masses, quick to cyclomastopathy onset, determined curative effect.

Detailed description of the invention

Be further detailed the present invention below by specific embodiment, exemplary effect is only played in following explanation, does not limit its content.If no special instructions, following raw material medicaments is weight portion.

embodiment 1

Pharmaceutical formulation is as follows: Abelmoschus esculentus Herb 35 parts, the Radix Astragali 35 parts, Concha Arcae 25 parts, Rhizoma Cyperi 25 parts, Radix Angelicae Sinensis 20 parts, Sargassum 20 parts, Rhizoma Drynariae 12 parts, Radix Bupleuri 12 parts, Herba Epimedii 10 parts, Semen Cuscutae 10 parts, Bulbus Fritillariae Thunbergii 5 parts, Radix Salviae Miltiorrhizae 5 parts, oryzanol 5 parts, Herba Salviae Chinensis 5 parts.

Preparation method is: by each crude drug mix homogeneously, is ground into 80-100 object fine powder, obtains final product.

embodiment 2

Pharmaceutical formulation is as follows: Abelmoschus esculentus Herb 30 parts, the Radix Astragali 45 parts, Concha Arcae 20 parts, Rhizoma Cyperi 30 parts, Radix Angelicae Sinensis 18 parts, Sargassum 25 parts, Rhizoma Drynariae 10 parts, Radix Bupleuri 15 parts, Herba Epimedii 5 parts, Semen Cuscutae 12 parts, Bulbus Fritillariae Thunbergii 3 parts, Radix Salviae Miltiorrhizae 8 parts, oryzanol 3 parts, Herba Salviae Chinensis 8 parts.

Preparation method is with embodiment 1.

embodiment 3

Pharmaceutical formulation is as follows: Abelmoschus esculentus Herb 45 parts, the Radix Astragali 30 parts, Concha Arcae 30 parts, Rhizoma Cyperi 20 parts, Radix Angelicae Sinensis 25 parts, Sargassum 18 parts, Rhizoma Drynariae 15 parts, Radix Bupleuri 10 parts, Herba Epimedii 12 parts, Semen Cuscutae 5 parts, Bulbus Fritillariae Thunbergii 8 parts, Radix Salviae Miltiorrhizae 3 parts, oryzanol 8 parts, Herba Salviae Chinensis 3 parts.

Preparation method is with embodiment 1.

embodiment 4

Pharmaceutical formulation is as follows: Abelmoschus esculentus Herb 30 parts, the Radix Astragali 30 parts, Concha Arcae 30 parts, Rhizoma Cyperi 30 parts, Radix Angelicae Sinensis 18 parts, Sargassum 18 parts, Rhizoma Drynariae 15 parts, Radix Bupleuri 15 parts, Herba Epimedii 5 parts, Semen Cuscutae 5 parts, Bulbus Fritillariae Thunbergii 8 parts, Radix Salviae Miltiorrhizae 8 parts, oryzanol 3 parts, Herba Salviae Chinensis 5 parts.

Preparation method is with embodiment 1.

embodiment 5

Pharmaceutical formulation is as follows: Abelmoschus esculentus Herb 45 parts, the Radix Astragali 45 parts, Concha Arcae 20 parts, Rhizoma Cyperi 20 parts, Radix Angelicae Sinensis 25 parts, Sargassum 25 parts, Rhizoma Drynariae 10 parts, Radix Bupleuri 10 parts, Herba Epimedii 12 parts, Semen Cuscutae 12 parts, Bulbus Fritillariae Thunbergii 3 parts, Radix Salviae Miltiorrhizae 3 parts, oryzanol 8 parts, Herba Salviae Chinensis 8 parts.

Preparation method is with embodiment 1.

embodiment 6

Pharmaceutical formulation is as follows: Abelmoschus esculentus Herb 45 parts, the Radix Astragali 45 parts, Concha Arcae 30 parts, Rhizoma Cyperi 30 parts, Radix Angelicae Sinensis 25 parts, Sargassum 18 parts, Rhizoma Drynariae 10 parts, Radix Bupleuri 10 parts, Herba Epimedii 5 parts, Semen Cuscutae 5 parts, Bulbus Fritillariae Thunbergii 3 parts, Radix Salviae Miltiorrhizae 8 parts, oryzanol 8 parts, Herba Salviae Chinensis 3 parts.

Preparation method is with embodiment 1.

below, by the curative effect of part clinical trial certificate medicine of the present invention

1, patient source

The cyclomastopathy patient this city hospital outpatient is medical is selected to test, totally 276 examples, 25 years old ~ 60 years old age, 38.4 years old mean age, patient has following at least one clinical symptoms: 1) one-sided or bilateral distending pain of the breast is held concurrently dull pain, and during the moon premenstrual and anxious state of mind, the pain increased; 2) one-sided or bilateral differs in size, and in the form of sheets, plate-like, graininess, streak, quality is pliable and tough, obscure boundary, with skin without adhesion, the lump in breast having tenderness; 3) breast molybdenum target X-ray film is shown in that comparatively uniform density increases shadow.

, Therapeutic Method

Above-mentioned patient is equally divided into 4 groups, and no difference of science of statistics between each group, has comparability, often organizes 69 people.Each group of patient takes the medicine of the embodiment of the present invention 1,2,3 and 5 respectively, and every day 3 times, each 5g, menstrual phase is withdrawn.

, criterion of therapeutical effect

Effective: lump in breast, pain disappear completely or mastalgia obviously disappears, lump major diameter reduces > 1/2;

Effective: lump in breast deliquescing, major diameter reduces > 1/3, simultaneously pain relief or disappearance;

Invalid: lump in breast major diameter is without reducing, and the symptoms such as pain are without significant change.

, therapeutic outcome

Each group of patient's continuous use is after 2 months, and treatment situation is as shown in the table:

	Effective number	Efficiently individual quantity	Invalid number	Effective percentage
					Embodiment 1	37	32	0	100%
Embodiment 2	23	39	7	89.9%
					Embodiment 3	23	38	8	88.4%
Embodiment 5	27	38	4	94.2%

Claims

1. treat a pharmaceutical composition for cyclomastopathy, it is characterized in that the crude drug comprising following weight portion: Abelmoschus esculentus Herb 30-45 part, Radix Astragali 30-45 part, Concha Arcae 20-30 part, Rhizoma Cyperi 20-30 part, Radix Angelicae Sinensis 18-25 part, Sargassum 18-25 part, Rhizoma Drynariae 10-15 part, Radix Bupleuri 10-15 part, Herba Epimedii 5-12 part, Semen Cuscutae 5-12 part, Bulbus Fritillariae Thunbergii 3-8 part, Radix Salviae Miltiorrhizae 3-8 part, oryzanol 3-8 part, Herba Salviae Chinensis 3-8 part.

2. pharmaceutical composition according to claim 1, is characterized in that the crude drug comprising following weight portion: Abelmoschus esculentus Herb 35 parts, the Radix Astragali 35 parts, Concha Arcae 25 parts, Rhizoma Cyperi 25 parts, Radix Angelicae Sinensis 20 parts, Sargassum 20 parts, Rhizoma Drynariae 12 parts, Radix Bupleuri 12 parts, Herba Epimedii 10 parts, Semen Cuscutae 10 parts, Bulbus Fritillariae Thunbergii 5 parts, Radix Salviae Miltiorrhizae 5 parts, oryzanol 5 parts, Herba Salviae Chinensis 5 parts.