CN102670925B - Medicament for treating irregular menstruation and preparation method thereof - Google Patents
Medicament for treating irregular menstruation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating irregular menstruation and a preparation method thereof. The medicament is mainly prepared from dangshen, prepared rehmannia rhizome, Chinese yam, dogwood, Chinese angelica, bitter orange, Chinese thorowax root, indian buead and red-rooted salvia root according to a certain weight proportion. The medicament can be prepared into any oral agent, has the functions of nourishing yin, supplementing blood, tonifying the kidney, soothing the liver and promoting flow of qi and blood, has quick response when used for treating irregular menstruation, and has a good curative effect and high curative ratio.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of menoxenia and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Menoxenia is common gynecological disease, shows as the abnormal of menstrual cycle or amount of bleeding, or stomachache and General Symptoms during month premenstrual, menstrual period.The traditional Chinese medical science is thought and is gone out all kidneys through water, points out that menopathy is relevant with renal function, and spleen, liver, QI and blood, chong channel, conception vessel, uterus are also relevant.Because era change living condition improves, add that living burden is heavy, social work pressure is large, a lot of women enjoy the torment of menoxenia, and menoxenia can cause other gynaecopathias.Doctor trained in Western medicine there is no the medicine of effective treatment menoxenia at present, mainly with patient self conditioning, is main.Therefore there is great demand to the Chinese medicine of effective treatment menoxenia in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the Chinese medicine of effective treatment menoxenia, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition that can effectively treat menoxenia.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Codonopsis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae, Radix Dipsaci, Folium Artemisiae Argyi, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Cyperi, Herba Leonuri, Radix Bupleuri, Poria, Radix Salviae Miltiorrhizae, Fructus Psoraleae, the Radix Astragali and Rhizoma Cimicifugae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating menoxenia disease.Wherein select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enters liver, kidney channel, has YIN nourishing, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, waist knee flaccidity, and chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deafness, blurred vision.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, there is spleen invigorating, tonifying the lung, reinforces the kidney, and the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Fructus Corni to be because its nature and flavor are sour, tepor, enters liver, kidney channel, has invigorating the liver and kidney, and arresting seminal emission gas is Gu the function of collapse is controlled soreness of waist and knee joint, dizzy, tinnitus, and sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quenches one's thirst, dripping urination, order is dark.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enters lung, kidney channel, astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Selecting Radix Dipsaci is because of its nature and flavor toil, tepor.Enter liver, kidney channel.Invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.Control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer is swollen.Selecting Folium Artemisiae Argyi is because of its nature and flavor toil, temperature.Enter spleen, liver, kidney channel.The blood of regulating the flow of vital energy, by cold-damp; Warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, the convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting Fructus Aurantii is because its nature and flavor toil, cool, enters lung, spleen, large intestine channel, has dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, controls chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Rhizoma Cyperi to be because the pungent micro-hard work of its nature and flavor is flat, enter liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Herba Leonuri to be because its nature and flavor are arduous, cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Radix Bupleuri to be because its nature and flavor are bitter, cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain, and bitter taste is deaf, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Fructus Psoraleae to be because its nature and flavor are pungent, temperature.Enter kidney channel.Reinforcing the kidney and supporting YANG.Control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Rhizoma Cimicifugae to be because the sweet pungent micro-hardship of its nature and flavor is cool, enter lung, spleen, stomach warp, have yang invigorating, deliver rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, and laryngalgia, aphtha scar, macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus tenesmus, carbuncle sore tumefacting virus.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:
6-15 grams of 18-32 grams of Radix Rehmanniae Preparata of Radix Codonopsis, 20-40 Keshan medicines
6-10 grams of 8-15 grams of Fructus Schisandrae Chinensis of 6-15 grams of Semen Cuscutae of Fructus Corni
5-15 grams of 5-15 grams of Folium Artemisiae Argyis of 5-10 grams of Radix Dipsacis of Radix Glycyrrhizae
4-19 grams of 5-20 grams of Rhizoma Cyperis of 15-25 grams of Fructus Aurantiis of Radix Angelicae Sinensis
5-20 grams, 7-20 grams of Poria of 10-20 grams of Radix Bupleuri of Herba Leonuri
10-20 grams of 8-18 grams of Radixs Astragali of 10-25 grams of Fructus Psoraleaes of Radix Salviae Miltiorrhizae
8-22 grams of Rhizoma Cimicifugaes
Preferable amount is
10 grams of 30 grams of Radix Rehmanniae Preparata of Radix Codonopsis, 30 Keshan medicines
8 grams of 10 grams of Fructus Schisandrae Chinensis of 10 grams of Semen Cuscutae of Fructus Corni
10 grams of 10 grams of Folium Artemisiae Argyis of 6 grams of Radix Dipsacis of Radix Glycyrrhizae
15 grams of 10 grams of Rhizoma Cyperis of 20 grams of Fructus Aurantiis of Radix Angelicae Sinensis
15 grams, 12 grams of Poria of 12 grams of Radix Bupleuri of Herba Leonuri
15 grams of 10 grams of Radixs Astragali of 20 grams of Fructus Psoraleaes of Radix Salviae Miltiorrhizae
10 grams of Rhizoma Cimicifugaes
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
2, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata, remove impurity;
3, Rhizoma Dioscoreae: choose clean impurity, be soaked in water to Rhizoma Dioscoreae central part soften for degree, pull out slightly and dry in the air, section dry or dry;
4, Fructus Corni: clean, except removal core and impurity, dry;
5, Semen Cuscutae: cross sieve and remove impurity, clean, dry;
6, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
7, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
8, Radix Dipsaci: clean silt, remove retained root head, run through rear section and dry, sieve removes chip;
9, Folium Artemisiae Argyi: choose decontamination, destemming, sieve dedust bits;
10, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when suitable to inside and outside humidity, and section is dried;
11, Fructus Aurantii: remove flesh, core, edulcoration, slightly soaks, and pulls out, softens, the hands of take can be pinched doubling as degree, and section, dries;
12, Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;
13, Herba Leonuri: choose decontamination, clean, run through, cutting, dries;
14, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
15, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
16, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
17, Fructus Psoraleae: the most impurity of winnowing with a dustpan, clean, dry;
18, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
19, Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries.
Two, preparation
1, the Radix Codonopsis of described weight, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae, Radix Dipsaci, Folium Artemisiae Argyi, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Cyperi, Herba Leonuri, Radix Bupleuri, Poria, Radix Salviae Miltiorrhizae, Fructus Psoraleae, the Radix Astragali, Rhizoma Cimicifugae medicine are decocted with water, add for the first time 4 times of amounts of water, soak after 30 minutes, decoct with high heat 10 minutes, use again slow fire boiling 20 minutes, obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, the medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, remove medicinal residues, decoction liquor is poured in container for the second time.
3, twice decoction liquor carried out to mixing and stirring, then use slow fire boiling 20 minutes, be divided into 2 doses and take.
Medicine of the present invention has the kidney invigorating, soothing the liver, and YIN nourishing is enriched blood, and the function of promoting flow of QI and blood, is used for the treatment of menoxenia, good effect, instant effect, and cure rate is high.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 10 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 5 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy menoxenia of the present invention:
1, physical data
Accept out-patient's totally 306 examples for medical treatment, light-duty class patient's 202 examples wherein, heavy class patient's 104 examples.
2, diagnostic criteria
Light-duty class menoxenia: menstrual cycle is irregular, lower abdomen pain, increase the weight of menstrual period, and leucorrhea amount is many at ordinary times, and yellow skin or HUANGBAI(sic), matter is thick, have taste.The infull person of atrophy of corpus iuteum is simultaneously with menorrhagia; Endometrium reparation is prolonged elder at menorrhea after date, still has a small amount of persistence vaginal hemorrhage.
Heavy class menoxenia: hemorrhagic anemia.The harm of menoxenia can cause hemorrhagic anemia due to long-term menorrhagia or irregular bleeding, occurs the phenomenons such as dizzy, weak, nervous, out of breath.Or there is even in advance menopause syndrome with insomnia, dreaminess, irritated irritability, energy physically-draining, hypomnesis, osteoporosis etc.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, heavy class patient is each serving with 1 dose, and every twice-daily, 5 days is a course for the treatment of, takes continuously 4 courses for the treatment of.Light-duty class patient is each serving with 1 dose, and every twice-daily, 5 days is a course for the treatment of, takes continuously 2 courses for the treatment of.During treatment, scorching, cold and cool food avoids pungent food.
4, efficacy assessment standard
Effective: menstrual cycle is normal and regular, amount of bleeding is stable, observes half a year without person repeatedly;
Take a turn for the better: menstrual cycle is progressively normal, amount of bleeding is stable.
Invalid: the confusion of the menstrual cycle, little when large during amount of bleeding, do not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy menoxenia patient of the present invention 306 examples, light-duty class patient's 202 examples wherein, effective 165 examples of result, obvious effective rate is 81.68%, 37 examples that take a turn for the better, improvement rate is 18.32%, total effective rate is 100%.Heavy class patient 104 examples, effective 88 examples of result, obvious effective rate is 84.62%, 13 examples that take a turn for the better, improvement rate is 12.5%, invalid 3 examples, total effective rate is 97.12%.
Claims (3)
1. a medicine for the treatment of menoxenia, is characterized in that: it is to be made by the crude drug in following weight range:
6-15 grams of 18-32 grams of Radix Rehmanniae Preparata of Radix Codonopsis, 20-40 Keshan medicines
6-10 grams of 8-15 grams of Fructus Schisandrae Chinensis of 6-15 grams of Semen Cuscutae of Fructus Corni
5-15 grams of 5-15 grams of Folium Artemisiae Argyis of 5-10 grams of Radix Dipsacis of Radix Glycyrrhizae
4-19 grams of 5-20 grams of Rhizoma Cyperis of 15-25 grams of Fructus Aurantiis of Radix Angelicae Sinensis
5-20 grams, 7-20 grams of Poria of 10-20 grams of Radix Bupleuri of Herba Leonuri
10-20 grams of 8-18 grams of Radixs Astragali of 10-25 grams of Fructus Psoraleaes of Radix Salviae Miltiorrhizae
8-22 grams of Rhizoma Cimicifugaes.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
10 grams of 30 grams of Radix Rehmanniae Preparata of Radix Codonopsis, 30 Keshan medicines
8 grams of 10 grams of Fructus Schisandrae Chinensis of 10 grams of Semen Cuscutae of Fructus Corni
10 grams of 10 grams of Folium Artemisiae Argyis of 6 grams of Radix Dipsacis of Radix Glycyrrhizae
15 grams of 10 grams of Rhizoma Cyperis of 20 grams of Fructus Aurantiis of Radix Angelicae Sinensis
15 grams, 12 grams of Poria of 12 grams of Radix Bupleuri of Herba Leonuri
15 grams of 10 grams of Radixs Astragali of 20 grams of Fructus Psoraleaes of Radix Salviae Miltiorrhizae
10 grams of Rhizoma Cimicifugaes.
3. the preparation method of medicine according to claim 1, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
(2) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata, remove impurity;
(3) Rhizoma Dioscoreae: choose clean impurity, be soaked in water to Rhizoma Dioscoreae central part soften for degree, pull out slightly and dry in the air, section dry or dry;
(4) Fructus Corni: clean, except removal core and impurity, dry;
(5) Semen Cuscutae: cross sieve and remove impurity, clean, dry;
(6) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(7) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
(8) Radix Dipsaci: clean silt, remove retained root head, run through rear section and dry, sieve removes chip;
(9) Folium Artemisiae Argyi: choose decontamination, destemming, sieve dedust bits;
(10) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(11) Fructus Aurantii: remove flesh, core, edulcoration, slightly soaks, and pulls out, softens, the hands of take can be pinched doubling as degree, and section, dries;
(12) Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;
(13) Herba Leonuri: choose decontamination, clean, run through, cutting, dries;
(14) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
(15) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(16) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(17) Fructus Psoraleae: the most impurity of winnowing with a dustpan, clean, dry;
(18) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(19) Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(2) preparation
(1) Radix Codonopsis of described weight, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae, Radix Dipsaci, Folium Artemisiae Argyi, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Cyperi, Herba Leonuri, Radix Bupleuri, Poria, Radix Salviae Miltiorrhizae, Fructus Psoraleae, the Radix Astragali, Rhizoma Cimicifugae medicine are decocted with water, add for the first time 4 times of amounts of water, soak after 30 minutes, decoct with high heat 10 minutes, use again slow fire boiling 20 minutes, obtain decoction liquor for the first time, decoction liquor is poured in container for the first time;
(2) medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, remove medicinal residues, decoction liquor is poured in container for the second time;
(3) twice decoction liquor carried out to mixing and stirring, then with slow fire boiling 20 minutes and get final product.
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Non-Patent Citations (5)
| Title |
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| 周蜻 * |
| 月经失调辨证论治浅析;钱秀红;《中医药临床杂志》;20081231;第20卷(第4期);341-342 * |
| 李文清,等.从肝虚论治月经不调.《山西中医》.2011,第27卷(第11期),58,60. * |
| 等.针药结合治疗月经后期30例临床研究.《云南中医中药杂志》.2011,第32卷(第5期),20-22. * |
| 钱秀红.月经失调辨证论治浅析.《中医药临床杂志》.2008,第20卷(第4期),341-342. |
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