Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation of caring and enlarging breast, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
1.5~6 parts of 1.5~6 parts of Fructus Trichosanthis of 1.5~6 parts of Fructus Liquidambaris of Semen Vaccariae (parched)
1~4 part of 1.5~6 parts of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of 1.5~6 parts of Concha Ostreae of prepared RHIZOMA CHUAN XIONG with yellow rice wine
0.1~2 part of 1~4 part of Radix Platycodonis of 1~4 part of Radix Paeoniae Alba (parched) of Radix Angelicae Sinensis (processed with wine)
0.1~2 part of 1~4 part of succinum of 0.1~2 part of Radix Bupleuri (processed with vinegar) of Endothelium Corneum Gigeriae Galli (parched)
The weight proportion of each raw material of optimization formula of the present invention is:
2~4 parts of 2~4 parts of Fructus Trichosanthis of 2~4 parts of Fructus Liquidambaris of Semen Vaccariae (parched)
1.5~2.5 parts of 2~4 parts of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of 2~4 parts of Concha Ostreae of prepared RHIZOMA CHUAN XIONG with yellow rice wine
0.5~1.5 part of 1.5~2.5 parts of Radix Platycodonis of 1.5~2.5 parts of Radix Paeoniae Alba (parched)s of Radix Angelicae Sinensis (processed with wine)
0.5~1.5 part of 1.5~2.5 parts of succinum of 0.5~1.5 part of Radix Bupleuri (processed with vinegar) of Endothelium Corneum Gigeriae Galli (parched)
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of 3 parts of Fructus Trichosanthis of 3 parts of Fructus Liquidambaris of Semen Vaccariae (parched)
2 parts of 3 parts of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of 3 parts of Concha Ostreae of prepared RHIZOMA CHUAN XIONG with yellow rice wine
1 part of 2 parts of Radix Platycodonis of 2 parts of Radix Paeoniae Alba (parched)s of Radix Angelicae Sinensis (processed with wine)
1 part of 2 parts of succinum of 1 part of Radix Bupleuri (processed with vinegar) of Endothelium Corneum Gigeriae Galli (parched)
Drug action mechanism among the present invention is as follows:
Semen Vaccariae (parched) nature and flavor hardship, flat.Return liver, stomach warp.Have promoting blood circulation to restore menstrual flow, stimulating milk secretion repercussive effect.Can treat that agalactia, amenorrhea, dysmenorrhea, difficult labour, stranguria with blood, blood band, black vaginal discharge, mastitis, acute mastitis are swollen and ache, incised wound is hemorrhage, lump in the abdomen, traumatic injury, alluvial, dribbling urination, arthralgia etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 238th page).
Fructus Liquidambaris nature and flavor hardship, flat.Return liver, kidney channel.Effect with dispelling wind and removing obstruction in the collateral, diuretic dehumidifying.Can treat that limbs arthralgia pain, contracture of the limbs, stomachache, edema, distension, amenorrhea, breast are little, carbuncle, anal fistula, scabies, eczema etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1246th page).
Sweet, the little hardship of Fructus Trichosanthis nature and flavor, cold.Return lung, stomach, large intestine channel.Has clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the effect of moisturizing laxation.Can treat the cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and the blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation etc.(the 85th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Prepared RHIZOMA CHUAN XIONG with yellow rice wine nature and flavor suffering, perfume (or spice).Return liver, gallbladder, pericardium channel.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Can treat menoxenia, amenorrhea dysmenorrhea, difficult labour, lump in the abdomen stomachache, the twinge of the breast side of body, arthralgia due to cold clonic spasm of the muscle, tumbling and swelling, headache due to pathogenic wind-heat, rheumatic arthralgia, skin infection swells and ache, placenta retention, cerebral ischemia, coronary heart disease, angina pectoris, atherosclerosis, hypertension, leukopenia due to the radiotherapy, chemotherapy, juvenile myopia, vitamin e deficiency, flu is dizzy, external plug nose treating malaria disease etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 171st page).
The Concha Ostreae nature and flavor are salty, be slightly cold.Return liver, gallbladder, kidney channel.Have tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.Can be used for the palpitation with fear insomnia, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 674th page).
The Radix Angelicae Sinensis (processed with wine) nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).
Radix Paeoniae Alba (parched) nature and flavor hardship, acid, be slightly cold.Return liver, spleen channel.Effect with suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, antibiotic, thrombocytosis.Can treat that the pain over the hypochondriac region, dysentery stomachache, night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, headache are dizzy, limb pain twin, blood deficiency and yellow complexion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 432nd page).
Stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar nature and flavor hardship, suffering, temperature.Return liver, gallbladder, stomach warp.Has soothing the liver dispelling the stagnated QI, the effect that removing food stagnancyization stagnates.Can treat distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food etc.(the 157th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Radix Bupleuri (processed with vinegar) nature and flavor hardship, be slightly cold.Return liver, gallbladder meridian.Effect with reconciling superficies and interior, soothing the liver, yang invigorating.Can treat alternate attack of chill and fever, fullness in the chest and hypochondriac pain, deafness, headache and dizziness, malaria, dysentery proctoptosis, menoxenia, uterine prolapse, flu, upper respiratory tract infection, hepatitis, cholecystitis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1004th page).
Radix Platycodonis nature and flavor hardship, suffering, flat, tepor.Return lung meridian.Have lung qi dispersing, sore-throat relieving, eliminate the phlegm, the effect of evacuation of pus.Can treat exogenous cough, abundant expectoration, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, hoarseness, skin infection difficulty in discharging of pus etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 982nd page).
The Endothelium Corneum Gigeriae Galli (parched) nature and flavor are sweet, and are flat.Return spleen, stomach, small intestinal, urinary bladder channel.Has invigorating the stomach and promoting digestion, the effect of arresting seminal emission.Can treat food stagnation and not disappear, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission etc.(the 151st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The succinum nature and flavor are sweet, flat.Go into the heart, liver, small intestine meridian.Has tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, the effect of relieving stranguria by diuresis.Cure mainly and stop stasis of blood stomachache, skin sore, traumatic injury etc. in bladder cancer, nasopharyngeal carcinoma, rectal cancer, infantile convulsion epilepsy, palpitation with fear insomnia, stranguria with blood hematuria, urinary obstruction, women's amenorrhea, puerperal.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1152nd page).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Semen Vaccariae (parched), Fructus Liquidambaris, Fructus Trichosanthis, prepared RHIZOMA CHUAN XIONG with yellow rice wine and Concha Ostreae, is ministerial drug with Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Alba (parched), Pericarpium Citri Reticulatae Viride and Radix Bupleuri (processed with vinegar), is adjuvant with Radix Platycodonis, Endothelium Corneum Gigeriae Galli (parched) and succinum.All medicines mutually and altogether the tool nourishing blood for regulating menstruation, dispel the wind stimulate the menstrual flow, the effect of spleen-benefiting mind-tranquilizing, caring and enlarging breast has determined curative effect, has no side effect taking convenience, cheap characteristics.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese medicine preparation is a peroral dosage form, as: tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention caring and enlarging breast of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
The standard of breast fitness:
1, skin of breast gloss is non-wrinkled, does not have depression, the non-pigment calmness, and the breast quality should be fine and smooth, plentiful, pliable and tough, and high resilience, rounded breasts is towering.
2, breast symmetry in both sides is of moderate size, and between the breast basal diameter 10-12cm, the height from basal surface to nipple (breast axle) is 5-6cm.
3, the position of breast is higher, and at 2-the 6th intercostal, nipple is positioned at the 4th intercostal.
4, breast can be divided into 3 types according to breast prolapse state.Collar plate shape: the length of breast prolapse is the right angle less than radius or the breast angle around the breast base portion.Pyramid type: the length of breast prolapse is acute angle greater than radius or the breast angle around the breast base portion.Sagging type: the length of breast prolapse is bigger, and nipple is sagging.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment caring and enlarging breast
As follows through clinical test results; Treat flat breast patient 37 examples, the age is 18~35 years old.Take embodiment 1 granule, each 1-3 bag, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.Satisfied 20 examples account for 54%, and satisfied 11 examples account for 29.7%, and dissatisfied 6 examples account for 16.2%, and total effective rate reaches 83.8%.After three course of therapy, patient's chest all has Feng Ting in various degree.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 granule takes by weighing raw material by following weight:
3 parts of 3 parts of Fructus Trichosanthis of 3 parts of Fructus Liquidambaris of Semen Vaccariae (parched)
2 parts of 3 parts of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of 3 parts of Concha Ostreae of prepared RHIZOMA CHUAN XIONG with yellow rice wine
1 part of 2 parts of Radix Platycodonis of 2 parts of Radix Paeoniae Alba (parched)s of Radix Angelicae Sinensis (processed with wine)
1 part of 2 parts of succinum of 1 part of Radix Bupleuri (processed with vinegar) of Endothelium Corneum Gigeriae Galli (parched)
Preparation method is to get succinum drying and crushing to 120~200 order fine powders earlier, get Semen Vaccariae (parched) again, Fructus Liquidambaris, Fructus Trichosanthis, prepared RHIZOMA CHUAN XIONG with yellow rice wine, Concha Ostreae, Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Alba (parched), Pericarpium Citri Reticulatae Viride, Radix Bupleuri (processed with vinegar), Radix Platycodonis and Endothelium Corneum Gigeriae Galli (parched) decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and succinum fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1~3 bag, three to four times on the one, three months is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
3 parts of 3 parts of Fructus Trichosanthis of 3 parts of Fructus Liquidambaris of Semen Vaccariae (parched)
2 parts of 3 parts of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of 3 parts of Concha Ostreae of prepared RHIZOMA CHUAN XIONG with yellow rice wine
1 part of 2 parts of Radix Platycodonis of 2 parts of Radix Paeoniae Alba (parched)s of Radix Angelicae Sinensis (processed with wine)
1 part of 2 parts of succinum of 1 part of Radix Bupleuri (processed with vinegar) of Endothelium Corneum Gigeriae Galli (parched)
Preparation method is to get succinum drying and crushing to 120~200 order fine powders earlier, get Semen Vaccariae (parched) again, Fructus Liquidambaris, Fructus Trichosanthis, prepared RHIZOMA CHUAN XIONG with yellow rice wine, Concha Ostreae, Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Alba (parched), Pericarpium Citri Reticulatae Viride, Radix Bupleuri (processed with vinegar), Radix Platycodonis and Endothelium Corneum Gigeriae Galli (parched) decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, and the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, drying, be ground into fine powder, add appropriate amount of starch, alcohol granulation after the drying, adds an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, three months is a course of treatment.
Embodiment 3 capsules take by weighing raw material by following weight:
3 parts of 3 parts of Fructus Trichosanthis of 3 parts of Fructus Liquidambaris of Semen Vaccariae (parched)
2 parts of 3 parts of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar of 3 parts of Concha Ostreae of prepared RHIZOMA CHUAN XIONG with yellow rice wine
1 part of 2 parts of Radix Platycodonis of 2 parts of Radix Paeoniae Alba (parched)s of Radix Angelicae Sinensis (processed with wine)
1 part of 2 parts of succinum of 1 part of Radix Bupleuri (processed with vinegar) of Endothelium Corneum Gigeriae Galli (parched)
Preparation method is to get succinum drying and crushing to 120~200 order fine powders earlier, get Semen Vaccariae (parched) again, Fructus Liquidambaris, Fructus Trichosanthis, prepared RHIZOMA CHUAN XIONG with yellow rice wine, Concha Ostreae, Radix Angelicae Sinensis (processed with wine), Radix Paeoniae Alba (parched), Pericarpium Citri Reticulatae Viride, Radix Bupleuri (processed with vinegar), Radix Platycodonis and Endothelium Corneum Gigeriae Galli (parched) decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, and the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, drying, be ground into fine powder, incapsulate.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, three months is a course of treatment.