CN102106991A

CN102106991A - Medicament for treating moderate/advanced liver cancer chemoembolization

Info

Publication number: CN102106991A
Application number: CN2011100275636A
Authority: CN
Inventors: 臧国敬; 陈学波; 段永英
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-01-20
Filing date: 2011-01-20
Publication date: 2011-06-29
Anticipated expiration: 2031-01-20
Also published as: CN102106991B

Abstract

The invention discloses a medicament for treating moderate/advanced liver cancer chemoembolization, which comprises the following raw materials in percentage by weight: 4.2-12.5% of ginseng, 2.7-6.5% of rhizoma atractylodis, 2.7-6.5% of rhizoma atractylodis macrocephalae, 4.2-12.5% of polyporus, 4.0-12.5% of Indian buead, 2.6-4.5% of rhizoma pinelliae, 4-6.7% of dried tangerine peel, 2.6-4.5% of radix bupleuri, 4.2-12.5% of radix paeoniae alba, 4.2-12.5% of Chinese angelica, 4.2-12.5% of pearl barley, 4.2-12.5% of herba artemisiae scopariae, 2.7-6.5% of cortex moutan, 2.7-6.5% of radix curcumae, 2.7-6.5% of endothelium corneum gigeriae galli, 8.4-18.7% of scorch-fried three immortals and 1.6-2.7% of liquorice root; and thus, the medicament can protect the liver function of the patient, enhance the curative effect, improve the life quality, prolong life of the patient and lighten financial burden of the family, and is particularly suitable for treating the moderate/advanced liver cancer chemoembolization.

Description

Medicine after the treatment mid and late liver cancer chemoembolization

Technical field:

The present invention relates to a kind of medicine for the treatment of mid and late liver cancer, particularly a kind of Chinese herbal medicine of taking behind the hepatic arterial chemoembolization that the mid and late liver cancer patient is carried out.

Background technology:

Hepatocarcinoma is a kind of modal malignant tumor in the digestive system, the sickness rate ascendant trend is obvious in the recent period, in treatment, mostly adopt operation, get involved, expectant treatment, development along with society, interventional therapy becomes people's first-selection, mainly due to interventional therapy is a kind of Wicresoft, safe operation, the degree that human body is hurt is less, but, interventional therapy repeatedly is bigger to patient's liver function injury, the financial burden of patient's spirit and quality of life and family all has great influence, at present, can only treat by Western medicine behind the patient of implementation interventional therapy, particularly postoperative 6-24 hour, patient's muscle power is very empty, can make the empty healthy energy of patient more empty, anticancer power further descends, for the relapse and metastasis of remaining cancer poison provides advantage, the cost of Western medicine is higher, and patient's burden is heavier, simultaneously, Western medicine has certain side effect, takes for a long time, can also produce certain untoward reaction, now, China does not also have a kind of Chinese herbal medicine that utilizes that the mid and late liver cancer patient is carried out carrying out hepatoprotective behind the hepatic arterial chemoembolization.

The invention task:

Purpose of the present invention is exactly a kind of liver function-protecting to the patient will be provided, heighten the effect of a treatment, improve quality of life, prolong patient's life, alleviate the medicine after the treatment mid and late liver cancer chemoembolization of household economy burden.

The object of the present invention is achieved like this: a kind of medicine for the treatment of after the mid and late liver cancer chemoembolization, it is characterized in that it by raw material by weight forming: Radix Codonopsis 4.2-12.5%, Rhizoma Atractylodis 2.7-6.5%, Rhizoma Atractylodis Macrocephalae 2.7-6.5%, Polyporus 4.2-12.5%, Poria 4.2-12.5%, Rhizoma Pinelliae 2.6-4.5%, Pericarpium Citri Reticulatae 4-6.7%, Radix Bupleuri 2.6-4.5%, Radix Paeoniae Alba 4.2-12.5%, Radix Angelicae Sinensis 4.2-12.5%, Semen Coicis 4.2-12.5%, Herba Artemisiae Scopariae 4.2-12.5%, Cortex Moutan 2.7-6.5%, Radix Curcumae 2.7-6.5%, Endothelium corneum 2.7-6.5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 8.4-18.7%, Radix Glycyrrhizae 1.6-2.7%.

Medicine after the treatment mid and late liver cancer chemoembolization of the present invention, it is made of by weight raw material: Radix Codonopsis 4.9-10%, Rhizoma Atractylodis 3.3-5%, Rhizoma Atractylodis Macrocephalae 3.3-5%, Polyporus 4.9-10%, Poria 4.9-10%, Rhizoma Pinelliae 3-3.5%, Pericarpium Citri Reticulatae 4.5-5%, Radix Bupleuri 3-3.5%, Radix Paeoniae Alba 4.9-10%, Radix Angelicae Sinensis 4.9-10%, Semen Coicis 4.9-10%, Herba Artemisiae Scopariae 4.9-10%, Cortex Moutan 3.3-5%, Radix Curcumae 3.3-5%, Endothelium corneum 3.3-5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-14.8%, Radix Glycyrrhizae 1.8-2.2%.

Medicine after the treatment mid and late liver cancer chemoembolization of the present invention, it also comprises following raw material by weight: Herba Artemisiae Annuae 4.9-10%, Radix Cynanchi Atrati 3.3-5%.

Medicine after the treatment mid and late liver cancer chemoembolization of the present invention, it also comprises following raw material by weight: Fructus Amomi 3-3.5%%, Pericarpium Arecae 9.5-10.5%, Semen Raphani 9.5-10.5%.

Medicine after the treatment mid and late liver cancer chemoembolization of the present invention, it also comprises following raw material by weight: Radix Rubiae 4.5-5%, Herba Agrimoniae 9.5-10.5%, Cacumen Platycladi 4.5-5%.

Medicine after the treatment mid and late liver cancer chemoembolization of the present invention to be to be made as decoction, also can make to be pill, capsule, medicamental pulverata electuary.

Hepatocarcinoma is mainly supplied whole tumor body by the ramose tumor vasa vasorum of Hepatic artery, in the active tumor neighboring area of growth of tumour cell, then exist many branch of portal vein simultaneously, in when, in the liver tumor taking place when, its tumor feeding can obtain blood from contiguous tremulous pulse by ramus anastomoticus and supply, the blood supply 90%-95% of hepatocarcinoma is above from Hepatic artery, so by the hepatic artery catheterization administration, can make medicine directly enter liver cancer tissue, improved partial drug level greatly, pair cell farthest kills and wounds, get involved the back and carry out partner treatment by Chinese herbal medicine, play the effect of attenuation synergistic, can avoid nauseating, vomiting, degradation digestive tract side effects under the appetite can alleviate the caused bone marrow depression reaction of chemotherapy, can avoid the leukocyte that may occur, platelet decline phenomenon, reinforcement is to the protection of liver function, avoids getting involved that medicine directly acts on liver and the infringement of the liver function that causes; Because Chinese herbal medicine has the effect of killing tumor, pressing down tumor, thereby, can kill the cancer poison to greatest extent, reduce the recurrence probability of cancer poison, utilization Chinese medicine changes the cancerous cell characteristic, thereby plays the effect of inhibition neoplasm metastasis.

Radix Codonopsis: invigorating middle warmer, QI invigorating is promoted the production of body fluid, and controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis; The present invention is mainly used in QI invigorating training unit;

Rhizoma Atractylodis: meridian distribution of property and flavor suffering, hardship, temperature.Return spleen, stomach, Liver Channel, drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia; The present invention is mainly used in the damp eliminating spleen invigorating of reducing phlegm;

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature is returned spleen, stomach warp, invigorating the spleen and benefiting QI, and the dampness diuretic, hidroschesis, antiabortive, be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement; The present invention is mainly used in QI invigorating training unit;

Polyporus: property is flat, sweet in the mouth, and promoting diuresis to eliminate damp pathogen cures mainly dysuria, drenches diseases such as drop burning pain, edema, and antitumaous effect is arranged; The present invention is mainly used in the damp eliminating spleen invigorating of reducing phlegm;

Poria: sweet in the mouth, light, property are flat, be used as medicine have promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, modern medicine study: Poria can the enhancing human body immunity function, and pachyman has tangible antitumor and protects the liver dirty effect; The present invention is mainly used in QI invigorating training unit;

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass cures mainly the cough with asthma abundant expectoration, vomiting regurgitation, the feeling of oppression and fullness in the chest and epigastrium headache is dizzy, uneasy sleeping at night, goiter sucutaneous nodule, swollen ulcer drug; The present invention is mainly used in the damp eliminating spleen invigorating of reducing phlegm;

Pericarpium Citri Reticulatae: the tool regulating QI and lowering the adverseness, transfer in the merit of appetizing, drying dampness to eliminate phlegm, cure mainly dirty contrary, the difficulty in urination and defecation of full vexed, the abdominal distention of the wet resistance of stagnation of QI in spleen and stomach, chest and diaphragm, anorexia, vomiting, lung qi retardance, cough with copious phlegm, also control acute mastitis from the beginning of; The present invention is mainly used in the damp eliminating spleen invigorating of reducing phlegm;

Radix Bupleuri: nature and flavor: hardship puts down, return through, go into liver, gallbladder meridian, function: deliver, bring down a fever, soothing the liver, resolving depression, yang invigorating, cure mainly cat fever, alternate attack of chill and fever, malaria, side of body distending pain, menoxenia, treating SHAO YANG disease by mediation, soothing liver-QI stomach function regulating, ascending up spleen-Qi and Yang.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse, invasion of the blood-chamber by heat; The present invention is mainly used in dispersing liver and promoting blood circulation;

The Radix Paeoniae Alba: the nature and flavor picric acid, cold, nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia; The present invention is mainly used in easing the affected liver and nourishes blood;

Radix Angelicae Sinensis: sweet, hot, temperature.Return liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; The present invention is mainly used in easing the affected liver and nourishes blood;

Semen Coicis: nature and flavor are cool in nature, sweet in the mouth, light, and the spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal can be used for treating edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen; The present invention is mainly used in the damp eliminating spleen invigorating of reducing phlegm;

Herba Artemisiae Scopariae: bitter, hot, be slightly cold, return spleen, stomach, liver, gallbladder meridian, clearing away damp-heat, the jaundice eliminating subcutaneous ulcer is used for jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis, and pharmaceutical research has function of gallbladder promoting, and liver function protecting is analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, effects such as coronary dilating; The present invention is mainly used in dispersing liver and promoting blood circulation;

Cortex Moutan: heat clearing away; Promoting blood circulation to remove blood stasis, the main epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The pathogenic bacteria later stage brimful of tears, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and pounce on the pain of injury; The rheumatism pyretic arthralgia; The present invention is mainly used in dispersing liver and promoting blood circulation;

Radix Curcumae: hot, bitter, cold, return liver, the heart, lung meridian, regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine; The present invention is mainly used in dispersing liver and promoting blood circulation;

Endothelium corneum: sweet, flat, puckery, spleen channel, strengthening the spleen to promote digestion, arresting seminal emission, eliminating mass fossil, main dyspepsia, dysentery, infantile malnutrition, the seminal emission enuresis, urinary system calculus, cholelithiasis, lump in the abdomen amenorrhea; The present invention is mainly used in stomach function regulating and helps digestion;

JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): be Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), this three flavors medicine all has the good removing food stagnancyization function that stagnates, but different separately characteristics are arranged, and Fructus Hordei Germinatus (parched to brown) has the effect of good digestible starch group food; Fructus Crataegi (parched to brown) is good at treating meat or greasy dyspepsia due to too much; Massa Medicata Fermentata (parched to brown) then is beneficial to digestion rice and flour food, and three medicines share, and can strengthen digestive function significantly; The present invention is mainly used in stomach function regulating and helps digestion;

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong; The present invention is mainly used in QI invigorating training unit;

Herba Artemisiae Annuae: bitter, hot, cold, return liver, gallbladder meridian, clear saturating deficiency-heat, removing heat from blood removes and steams expelling summer-heat, preventing the attack (or recurrence) of malaria; The present invention is mainly used in reducing the asthenic fever;

Radix Cynanchi Atrati: bitter in the mouth, salty, cold in nature, cure mainly warm, the fever of the body macule, the hectic fever hectic fever due to YIN-deficiency, the cough due to lung-heat, puerperal fidgets due to deficiency, pyretic stranguria, stranguria with blood, laryngopharynx swelling and pain, sore and toxic, venom; The present invention is mainly used in reducing the asthenic fever;

Fructus Amomi: meridian distribution of property and flavor: suffering, temperature is returned spleen, stomach, kidney channel, cures mainly the removing dampness appetizing, and warming spleen and stopping diarrha, it is antiabortive to regulate the flow of vital energy, and is used for turbid damp obstructing in middle-JIAO, and the gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, vomiting is had loose bowels, pregnancy reactions, frequent fetal movement; The present invention is mainly used in the relieving distension of regulating the flow of vital energy;

Pericarpium Arecae: acrid in the mouth, slightly warm in nature is returned spleen, stomach, large intestine, small intestine meridian, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence is used for retention of damp leading to blockage of QI, and breast abdominal distention is vexed, and it is not well to defecate, edema, beriberi, dysuria; The present invention is mainly used in the relieving distension of regulating the flow of vital energy;

Semen Raphani:: property is flat, acrid in the mouth, sweet, return lung, spleen, stomach warp, help digestion to remove and expand lowering the adverse-rising QI to resolve phlegm, being used for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up and breathes with cough, go into spleen, stomach, lung meridian, can help digestion to remove and expand, effect is remarkable, the title that " falling wall towards wall " arranged, clinical commonly using in treatment real (food, wet, stagnant) disease; The present invention is mainly used in the relieving distension of regulating the flow of vital energy;

Radix Rubiae: hardship, return Liver Channel, removing heat from blood, hemostasis, blood stasis dispelling stimulates the menstrual flow, and antitussive is eliminated the phlegm, be used for spitting blood epistaxis, metrorrhagia, traumatic hemorrhage, the resistance of the amenorrhea stasis of blood, arthralgia, tumbling and swelling, can treat the hemorrhagic illness, chronic tracheitis, chronic diarrhea, rheumatic arthritis, treatment soft tissue injury, treatment leukopenia; The present invention is mainly used in cooling blood for hemostasis;

Herba Agrimoniae: bitter, puckery, flat, GUIXIN, Liver Channel, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, detoxifcation is used for hemoptysis, spits blood, metrostaxis, malaria, dysentery is taken off the power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia; The present invention is mainly used in cooling blood for hemostasis;

Cacumen Platycladi: bitter, puckery, cold, return lung, liver, spleen channel, cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair; The present invention is mainly used in cooling blood for hemostasis.

More than all medicine compatibilities, play invigorating the spleen and regulating the stomach with angry blood, eliminate the phlegm and invigorate blood circulation with the tunnel that stimulates the menstrual flow, tonify without causing stagnation, eliminating evil effect of not hindering healthy energy, and make simple, taking convenience, have no side effect, cheap.

The present invention has good result by clinical trial, and two group of 60 routine middle and terminal cancer patient all adopted Seldinger technology percutaneous femoral artery puncture, conduit is inserted Hepatic artery and feeding artery carries out chemoembolization; The A group is simple hepatic arterial chemoembolization, and the B group is carried out treatment by Chinese herbs for postoperative, and two groups relatively see Table 1,2

Table 1: survival rate situation

	0.5 year	1 year	2 years	3 years
					The A group	90.5％	80.4％	45％	20.1％
The B group	96％	86.5％	68.2％	35.5％

Table 2: quality of life situation (symptom occurrence rate in life cycle)

	Stomachache	Heating	Symptom of digestive tract	Other
					The A group	22.6％	19.9％	69.9％	38.8％
The B group	11.6％	3％	6％

By above-mentioned two tables as can be seen, B group patient's survival rate is organized apparently higher than A, and especially the survival rate in the 3rd year is learned X by statistics ²Check shows notable difference (p＜005), illustrates that the treatment of Chinese medicine is of value to secular curative effect; Quality of life the aspect, B group patient also apparently higher than the A group, and notable difference (p＜005) is arranged on the statistics, illustrate that the patient of Chinese medicine partner treatment can obtain life quality preferably; Other refer to influence other factors of patients ' life quality, and are bad etc. as weak, emotional lability, sleep; By the treatment of Chinese herbal medicine, 12 routine patient's survival, stable disease were at present arranged still after 3 years.

The specific embodiment:

Embodiment 1: to make an auxiliary medicine agent is example, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, Poria 15 grams, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 15 grams, Radix Curcumae 10 grams, Endothelium corneum 10 grams, each 10 gram of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 6 grams; Elder generation mixes above-mentioned raw material and is put in the medicinal cupping, puts 3 in Rhizoma Zingiberis Recens again, injects water then in medicinal cupping, and water will soak medical herbs, soaked to decoct after 20-30 minute, fried in shallow oil altogether 2 times, and extracting juice 400-500 liter took in 1-2 days, and this prescription is suitable for all patients.

Embodiment 2: to make an auxiliary medicine agent is example, gets Radix Codonopsis 15 grams, Rhizoma Atractylodis 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Polyporus 30 grams, Poria 30 grams, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 15 grams, Radix Angelicae Sinensis 20 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 15 grams, Cortex Moutan 10 grams, Radix Curcumae 15 grams, Endothelium corneum 15 grams, each 15 gram of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 6 grams, Herba Artemisiae Annuae 30 grams, Radix Cynanchi Atrati 15 grams; Manufacture method is with embodiment 1, the patient that this prescription is suitable for having a low fever.

Embodiment 3: to make an auxiliary medicine agent is example, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, Poria 15 grams, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 10 grams, Radix Curcumae 15 grams, Endothelium corneum 10 grams, each 10 gram of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 6 grams, Fructus Amomi 10 grams, Pericarpium Arecae 30 grams, Semen Raphani 30 grams; Manufacture method is with embodiment 1, and this prescription is suitable for the patient of abdominal distention.

Embodiment 4: to make an auxiliary medicine agent is example, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, Poria 15 grams, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 30 grams, Semen Coicis 15 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 15 grams, Radix Curcumae 10 grams, Endothelium corneum 10 grams, each 10 gram of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 6 grams, Radix Rubiae 15 grams, Herba Agrimoniae 30 grams, Cacumen Platycladi 15 grams; Manufacture method is with embodiment 1, and this prescription is suitable for the patient of tooth epistaxis.

Embodiment 5: to make an auxiliary medicine is example, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 30 grams, Poria 30 grams, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 15 grams, Cortex Moutan 10 grams, Radix Curcumae 15 grams, Endothelium corneum 15 grams, each 15 gram of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 6 grams; If having a low fever, patient adds Herba Artemisiae Annuae 15 grams, Radix Cynanchi Atrati 10 grams again; If patient's abdominal distention adds Fructus Amomi 10 grams, Pericarpium Arecae 30 grams, Semen Raphani 30 grams again; If patient's tooth epistaxis adds Radix Rubiae 15 grams, Herba Agrimoniae 30 grams, Cacumen Platycladi 15 grams again; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material, the medicine that granule is little filters out, for future use, grinding into powder again that granule is big sieved, and finally reaches the purpose of sieving; Then 1 kilogram of Mel is put into pot with the low baking temperature refining, coagulated as the maltosemalt sugar shape, the not order of stirring is burnt; At last refined honey is mixed with above-mentioned medicamental pulverata and rubs by evenly, place half an hour approximately, rub once more by, the honeyed pill of making about 6 grams gets final product, and divides to take in 1-2 days.

Embodiment 6, be example, get Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, Poria 15 grams, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 15 grams, Radix Curcumae 10 grams, Endothelium corneum 10 grams, each 10 gram of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Radix Glycyrrhizae 6 grams to make an auxiliary medicine; If having a low fever, patient adds Herba Artemisiae Annuae 15 grams, Radix Cynanchi Atrati 10 grams again; If patient's abdominal distention adds Fructus Amomi 10 grams, Pericarpium Arecae 30 grams, Semen Raphani 30 grams again; If patient's tooth epistaxis adds Radix Rubiae 15 grams, Herba Agrimoniae 30 grams, Cacumen Platycladi 15 grams again; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material, the medicine that granule is little filters out, for future use, grinding into powder again that granule is big sieved, and finally reaches the purpose of sieving; Be that the unit pack gets final product with 6 grams at last, divide to take in 1-2 days.

Embodiment 7: to make an auxiliary medicine is example, and raw-material proportioning is with embodiment 6; Manufacture method incapsulates with 0.5 gram at last as different from Example 6 and gets final product, and divides to take in 1-2 days.

Claims

1. medicine for the treatment of after the mid and late liver cancer chemoembolization, it is characterized in that it by following raw material by weight forming:

Radix Codonopsis 4.2-12.5%, Rhizoma Atractylodis 2.7-6.5%, Rhizoma Atractylodis Macrocephalae 2.7-6.5%, Polyporus 4.2-12.5%, Poria 4.2-12.5%, Rhizoma Pinelliae 2.6-4.5%, Pericarpium Citri Reticulatae 4-6.7%, Radix Bupleuri 2.6-4.5%, Radix Paeoniae Alba 4.2-12.5%, Radix Angelicae Sinensis 4.2-12.5%, Semen Coicis 4.2-12.5%, Herba Artemisiae Scopariae 4.2-12.5%, Cortex Moutan 2.7-6.5%, Radix Curcumae 2.7-6.5%, Endothelium corneum 2.7-6.5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 8.4-18.7%, Radix Glycyrrhizae 1.6-2.7%.

2. the medicine after the treatment mid and late liver cancer chemoembolization according to claim 1, it is characterized in that it by following raw material by weight forming:

Radix Codonopsis 4.9-10%, Rhizoma Atractylodis 3.3-5%, Rhizoma Atractylodis Macrocephalae 3.3-5%, Polyporus 4.9-10%, Poria 4.9-10%, Rhizoma Pinelliae 3-3.5%, Pericarpium Citri Reticulatae 4.5-5%, Radix Bupleuri 3-3.5%, Radix Paeoniae Alba 4.9-10%, Radix Angelicae Sinensis 4.9-10%, Semen Coicis 4.9-10%, Herba Artemisiae Scopariae 4.9-10%, Cortex Moutan 3.3-5%, Radix Curcumae 3.3-5%, Endothelium corneum 3.3-5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-14.8%, Radix Glycyrrhizae 1.8-2.2%.

3. the medicine after the treatment mid and late liver cancer chemoembolization according to claim 1 and 2 is characterized in that it also comprises following raw material by weight: Herba Artemisiae Annuae 4.9-10%, Radix Cynanchi Atrati 3.3-5%.

4. the medicine after the treatment mid and late liver cancer chemoembolization according to claim 1 and 2 is characterized in that it also comprises following raw material by weight: Fructus Amomi 3-3.5%%, Pericarpium Arecae 9.5-10.5%, Semen Raphani 9.5-10.5%.

5. the medicine after the treatment mid and late liver cancer chemoembolization according to claim 1 and 2 is characterized in that it also comprises following raw material by weight: Radix Rubiae 4.5-5%, Herba Agrimoniae 9.5-10.5%, Cacumen Platycladi 4.5-5%.