CN102552855B - Medicine for treating gastrectasia and preparation method thereof - Google Patents
Medicine for treating gastrectasia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating gastrectasia and a preparation method of the medicine for treating the gastrectasia. The medicine for treating the gastrectasia is mainly prepared by rhizoma bletillae, codonopsis pilosula, semen raphani, pericarpium citri reticulatae, mangnolia officinalis, endothelium corneum gigeriae galli, salviae miltiorrhizae, ligusticum wallichii, radix polygonati officinalis, medicated leaven, Chinese-date, pinellia ternate, elecampane, rhizoma zingiberis, fructus aurantii, perilla fruit, peach kernel, angelica sinensis, ochre, magnet, poria cocos and mentha haplocalyx according to a certain weight ratio. The medicine for treating the gastrectasia has the functions of tonifying spleen and stomach, conditioning intestines and stomach, relieving choking sensation in chest and abdominal distension, helping digestion and reconciling the block of the middle warmer, and tonifying stomach and promoting fluid and is short in course of treatment, quick in effect, of no occurrence after treatment and free from toxic and side effects.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of flatulence and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Flatulence is a common sympton of digestive tract disease, refers to that patient feels that gastral cavilty support is swollen, and outward appearance has again a kind of disease of distension form performance, can be simultaneously with gastralgia, the clinical manifestation such as feel sick, vomit, can not take food.Generally be glutted after meal, belch, uneasy in either sitting or lying is had lost all desire for food and drink; The repeatability of flatulence and chronicity can cause gastritis, digestive tract ulcer, even can develop into gastric cancer.Flatulence is brought great inconvenience to patient's daily life and work, patient body is become thin, spirit depressing.At present, western medicine flatulence poor effect, and more side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of effective treatment flatulence.
Summary of the invention
The inventor has finally found the medicine of effective treatment flatulence, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine that can effectively treat flatulence.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Codonopsis, Semen Raphani, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Polygonati Odorati, Massa Medicata Fermentata, Fructus Jujubae, the Rhizoma Pinelliae, Fructus Amomi, Radix Glycyrrhizae, Fructus Hordei Germinatus, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Herba Asari, Fructus Amomi Rotundus, Fructus Crataegi, Radix Ophiopogonis, the Radix Aucklandiae, Rhizoma Zingiberis, Fructus Aurantii, Fructus Perillae, Semen Persicae, Radix Angelicae Sinensis, Haematitum, Magnetitum, Poria, Herba Menthae medicine to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby can effectively treat the recurrence of flatulence.Wherein selecting Pseudobulbus Bletillae (Rhizoma Bletillae) is that cold enters lung meridian, and tonifying the lung is arranged because of its property bitter but sweet flavor, hemostasis, and detumescence is given birth to and is seen, and the function of sore is controlled lung and is hindered hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, the soup fire is burnt, rhagadia manus et pedis.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating the spleen and replenishing QI is arranged, the function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Semen Raphani to be because its property acrid-sweet flavor is flat, enter lung, stomach warp, therapeutic method to keep the adverse QI flowing downwards Dingchuan is arranged, the function that eliminates indigestion and phlegm is controlled the cough phlegm dyspnea, stagnation of QI due to dyspepsia, and abdominal distention uncomfortable in chest, heavy behind the dysentery.Select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, hot, temperature is returned lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged, and the function of drying dampness to eliminate phlegm is controlled fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Selecting Cortex Magnoliae Officinalis is that temperature enters spleen, stomach, large intestine channel, and warming middle-JIAO is arranged because of its nature and flavor toil, the therapeutic method to keep the adverse QI flowing downwards, and dampness, the function of expectorant is controlled breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, the cold-damp dysentery.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnantly, the function of strengthening the spleen and stomach is controlled the food stagnation distension, vomiting regurgitation, and dysentery, infantile malnutrition is quenched one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor enters the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving is controlled angina cordis, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia ， mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature enters liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, the stomach warp has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst is controlled the calentura sun and is hindered, cough, excessive thirst, deficient fever, rapid digestion of food are easily hungry, frequent micturition.Selecting Massa Medicata Fermentata is that temperature enters upright stone tablet, stomach warp, and invigorating the spleen and regulating the stomach is arranged because of the sweet suffering of its nature and flavor, and the function in the accent that helps digestion is controlled retention of food and drink, feeling of stuffiness in chest abdominal distention, and vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.Select Fructus Jujubae to be because its nature and flavor are sweet, temperature enters spleen, stomach warp, and the spleen reinforcing stomach function regulating is arranged, and supplementing QI for promoting the production of body fluid transfers battalion to defend, and separates the function of poison of drug, controls the insufficiency of stomach lack of appetite, the weak loose stool of spleen, and qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select the Rhizoma Pinelliae to be because its nature and flavor are hot, temperature, poisonous, enter spleen, stomach warp, drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, the function of clear painful abdominal mass eliminating stagnation is controlled the vomiting of damp-phlegm cold drink, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select Fructus Amomi to be because its nature and flavor are hot, temperature enters spleen, stomach warp, have in the circulation of qi promoting accent, and stomach function regulating, the function of being amusing, it is swollen to control the stomachache painful abdominal mass, and the anorexia dyspepsia is choked every vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription is processed usefulness, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select Fructus Hordei Germinatus to be because its nature and flavor are sweet, tepor enters spleen, stomach warp, have to help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards is controlled food stagnation and is not disappeared, distension and fullness in the abdomen, and inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, spleen invigorating is arranged, tonifying the lung is reinforced the kidney, and the function that benefit is smart is controlled diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease is quenched one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Radix Et Rhizoma Rhei to be because its nature and flavor are bitter, cold, enter stomach, large intestine, liver footpath, the poison of purging heat is arranged, removing mass stagnates, the function of clots absorbing blood is controlled the excess-heat constipation, and delirium is gone mad, the food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood epistaxis, YANG jaundice, edema, stranguria with turbid discharge, it is red to urinate, the carbuncle and ulcer toxic swelling, furuncle, burn.Select Herba Asari to be because its nature and flavor are hot, temperature enters lung, kidney channel, dispel the wind, and cold expelling, row water is opened the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Fructus Amomi Rotundus to be because its nature and flavor are hot, temperature enters lung, spleen channel, and sector-style is arranged, and warming the stomach helps digestion, and the function of alleviating distention in middle-JIAO is controlled the stagnation of QI, and dyspepsia is uncomfortable in chest, abdominal distention, eructation, dysphagic, tell contrary, regurgitation, malaria.Select Fructus Crataegi to be because its nature and flavor acid is sweet, tepor enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function is controlled meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's's breast food is stagnated.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid is controlled dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, hinder in calentura Tianjin, dry mouth and throat, constipation.Select the Radix Aucklandiae to be because its nature and flavor are arduous, temperature enters lung, liver, spleen channel, and promoting the circulation of QI to relieve pain are arranged, and the function of warming middle-JIAO for easing the stomach is controlled the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, and dysentery tenesmus, colic of cold type are had loose bowels in vomiting.Select Rhizoma Zingiberis to be because its nature and flavor are hot, heat enters spleen, stomach, lung meridian, and there have warming middle-JIAO to pursue to be cold, and the function that recuperating depleted YANG is promoted blood circulation is controlled trusted subordinate's cold type of pain, vomit and diarrhoea, and the cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.Selecting Fructus Aurantii is that cold enters lung, spleen, large intestine channel, and dispelling the stagnated QI is arranged because of its nature and flavor toil, row expectorant, and the function of removing food stagnancy is controlled chest and diaphragm expectorant and is stagnated, the feeling of stuffiness in chest, the side of body is swollen, food stagnation, eructation, vomiting weighs proctoptosis, uterine prolapse behind the dysentery.Select Fructus Perillae to be because its nature and flavor are hot, temperature enters lung, large intestine channel, and the therapeutic method to keep the adverse QI flowing downwards is arranged, expectorant, and lung moistening, the function of wide intestinal is controlled cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Haematitum to be because its nature and flavor are bitter, sweet, be slightly cold, return liver, stomach, heart channel, suppressing the hyperactive liver and subsiding YANG is arranged, the important city sending down the abnormal ascending QI, the function of cooling blood for hemostasis, it is front dizzy to control head, and cardiopalmus is demented, infantile convulsion, vomiting, eructation, cough and asthma is spitted blood, epistaxis, metrorrhagia is had blood in stool, hematuria.Select Magnetitum to be because its nature and flavor suffering is salty, flat, enter kidney, liver, lung meridian, calming down the floating YANG to promote inspiration for relieving dyspnea is arranged, the function of tranquillizing the mind by relieving convulsion is controlled the vertigo, Hiccough and deaf, dyspnea due to deficiency ， Jing Epilepsy, palpitation with a distress feeling.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Herba Menthae to be because its nature and flavor are hot, cold enters lung, Liver Channel, and dispelling wind is arranged, and heat radiation is warded off dirtyly, and the function of detoxifcation is controlled affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope:
Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 gram Radix Codonopsis 10-12 gram Semen Raphanis 12-15 grams
Pericarpium Citri Reticulatae 8-12 gram Cortex Magnoliae Officinalis 8-12 gram Endothelium Corneum Gigeriae Galli 8-12 grams
Radix Salviae Miltiorrhizae 12-18 gram Rhizoma Chuanxiongs 8-12 gram Rhizoma Polygonati Odorati 10-12 grams
Massa Medicata Fermentata 8-10 gram Fructus Jujubaes 10-15 gram Rhizoma Pinelliaes 10-12 grams
Fructus Amomi 6-8 gram Radix Glycyrrhizaes 6-8 gram Fructus Hordei Germinatus 8-10 grams
Rhizoma Dioscoreae 8-12 gram Radix Et Rhizoma Rhei 8-12 gram Herba Asaris 10-15 grams
Fructus Amomi Rotundus 10-12 Keshan short, bristly hair or beards 4-8 gram Radix Ophiopogonis 6-10 grams
The Radix Aucklandiae 10-12 gram Rhizoma Zingiberiss 10-14 gram Fructus Aurantiis 10-12 grams
Fructus Perillae 10-14 gram Semen Persicaes 12-16 gram Radix Angelicae Sinensis 15-25 grams
Haematitum 4-6 gram Magnetitums 4-8 gram Poria 10-14 grams
Herba Menthae 3-6 grams
Preferable amount is
Pseudobulbus Bletillae (Rhizoma Bletillae) 15 gram Radix Codonopsis 10 gram Semen Raphanis 15 grams
Pericarpium Citri Reticulatae 10 gram Cortex Magnoliae Officinalis 10 gram Endothelium Corneum Gigeriae Galli 10 grams
Radix Salviae Miltiorrhizae 15 gram Rhizoma Chuanxiongs 10 gram Rhizoma Polygonati Odorati 12 grams
The Massa Medicata Fermentata 9 gram Fructus Jujubaes 12 gram Rhizoma Pinelliaes 10 grams
Fructus Amomi 8 gram Radix Glycyrrhizaes 6 gram Fructus Hordei Germinatus 10 grams
Rhizoma Dioscoreae 10 gram Radix Et Rhizoma Rhei 10 gram Herba Asaris 12 grams
Fructus Amomi Rotundus 10 Keshan short, bristly hair or beards 6 gram Radix Ophiopogonis 8 grams
The Radix Aucklandiae 10 gram Rhizoma Zingiberiss 12 gram Fructus Aurantiis 12 grams
Fructus Perillae 12 gram Semen Persicaes 15 gram Radix Angelicae Sinensis 20 grams
Haematitum 5 gram Magnetitums 6 gram Poria 12 grams
Herba Menthae 4 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, it is suitable to humidity to dry in the air, section, drying;
2, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
3, Semen Raphani: remove impurity, cleaning, drying.Time spent smashs to pieces;
4, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
5, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding is dried;
6, Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
7, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
8, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
9, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section is dried;
10, Massa Medicata Fermentata: get wheat bran and spread and spare in heat pot, the cigarette of having waited is poured Massa Medicata Fermentata into, fries to yellow, takes out, and sieves and removes wheat bran, cools;
11, Fructus Jujubae: choose clean impurity, dry;
12, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
13, Fructus Amomi: choose decontamination and shell, smash to pieces;
14, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
15, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;
16, Rhizoma Dioscoreae: choose clean impurity, be soaked in water and pull out and slightly dry in the air for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;
17, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
18, Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
19, Fructus Amomi Rotundus: choose clean impurity, the sieve scurf removing is smashed, or is peelled off shell, gets core and smashes usefulness;
20, Fructus Crataegi: choose clean impurity, the sieve enucleation;
21, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
22, the Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried.
23, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;
24, Fructus Aurantii: remove flesh, nuclear, edulcoration slightly soaks, and pulls out, moistens softly, can pinch doubling as degree take hands, and section is dried;
25, Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;
26, Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;
27, Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
28, Haematitum: get crude drug, remove impurity, cleaning, drying break into fragment or are ground into coarse powder;
29, Magnetitum: choose decontamination, smash, sieve;
30, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
31, Herba Menthae: choose clean impurity, remove undesirable root, leaf is trembled down in addition put first, then stem is sprayed clear water, run through rear cutting, dry, again with leaf and even.
Two, preparation
1, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Codonopsis, Semen Raphani, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Polygonati Odorati, Massa Medicata Fermentata, Fructus Jujubae, the Rhizoma Pinelliae, Fructus Amomi, Radix Glycyrrhizae, Fructus Hordei Germinatus, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Herba Asari, Fructus Amomi Rotundus, Fructus Crataegi, Radix Ophiopogonis, the Radix Aucklandiae, Rhizoma Zingiberis, Fructus Aurantii, Fructus Perillae, Semen Persicae, Radix Angelicae Sinensis, Haematitum, Magnetitum, Poria, the Herba Menthae crude drug of described weight are put into the container of boiling medicine, add for the first time 3 times of amounts of water, soak after 30 minutes, intense fire decocts boiling 20 minutes, with slow fire boiling 20 minutes and get final product, decoction liquor is poured in the container for the first time again.
2, add 1.5 times of amounts of water for the second time, boil with high heat first, used slow fire boiling 20 minutes again, decoction liquor is poured in the container for the second time.
3, twice decoction liquor carried out mixing and stirring, be divided into 3 doses and get final product.
Medicine of the present invention has invigorating the spleen and regulating the stomach, the intestines and stomach coordinating, abdominal distention uncomfortable in chest, help digestion transfer in, the function of reinforcing stomach reg fluid, be used for the treatment of flatulence, short treating period, instant effect, non-relapse after healing, have no side effect.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 40 of rabbit, the male and female dual-purpose, body weight 2.2-2.6kg divides two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day three times, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy flatulence of the present invention
1, physical data
Accept out-patient's totally 160 examples for medical treatment, patients with mild 90 examples wherein, middle severe patient's 70 examples.
2, diagnostic criteria
It is how irregular that slight flatulence shows as Upper abdominal pain, is generally diffusivity epigastrium causalgia, dull pain, distending pain etc.; Because of achlorhydria, the factors such as gastric fermentation gas make the gastric gas accumulation, cause belch to occur.Simultaneously, the symptoms such as inappetence, nausea and vomiting, constipation appear in patient.
Middle severe flatulence shows as upper abdomen pain often occurs, and sharp ache, and because of achlorhydria, the factors such as gastric fermentation gas make the gastric gas accumulation, causes belch to occur.Simultaneously, the symptoms such as serious inappetence, nausea and vomiting, constipation appear in patient.The repeatability of middle severe flatulence and chronicity can cause gastritis, digestive tract ulcer, even can develop into gastric cancer.
3, Therapeutic Method
Select above-mentioned medicament, take to the patient, patients with mild is each serving with 1 dose, and every day early, respectively take 1 evening, and 15 days is a course for the treatment of, takes continuously 2 courses for the treatment of.Middle severe patient is each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 15 days is a course for the treatment of, takes continuously 3 courses for the treatment of.
4, efficacy assessment standard
Produce effects: flatulence transference cure, body constitution recover normal, observe half a year without the recidivist;
Take a turn for the better: the flatulence symptom is clearly better, and body constitution is progressively recovered;
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy flatulence patient 160 examples of the present invention, patients with mild 90 examples wherein, produce effects 86 examples as a result, obvious effective rate is 95.56%, 3 examples that take a turn for the better, improvement rate is 3.33%, invalid 1 example, total effective rate is 98.89%.Middle severe patient's 70 examples, produce effects 62 examples as a result, obvious effective rate is 88.57%, 5 examples that take a turn for the better, improvement rate is 7.14%, invalid 3 examples, total effective rate is 95.71%.
Claims (3)
1. medicine for the treatment of flatulence, it is characterized in that: it is to be made by the crude drug in the following weight range:
Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 gram Radix Codonopsis 10-12 gram Semen Raphanis 12-15 grams
Pericarpium Citri Reticulatae 8-12 gram Cortex Magnoliae Officinalis 8-12 gram Endothelium Corneum Gigeriae Galli 8-12 grams
Radix Salviae Miltiorrhizae 12-18 gram Rhizoma Chuanxiongs 8-12 gram Rhizoma Polygonati Odorati 10-12 grams
Massa Medicata Fermentata 8-10 gram Fructus Jujubaes 10-15 gram Rhizoma Pinelliaes 10-12 grams
Fructus Amomi 6-8 gram Radix Glycyrrhizaes 6-8 gram Fructus Hordei Germinatus 8-10 grams
Rhizoma Dioscoreae 8-12 gram Radix Et Rhizoma Rhei 8-12 gram Herba Asaris 10-15 grams
Fructus Amomi Rotundus 10-12 Keshan short, bristly hair or beards 4-8 gram Radix Ophiopogonis 6-10 grams
The Radix Aucklandiae 10-12 gram Rhizoma Zingiberiss 10-14 gram Fructus Aurantiis 10-12 grams
Fructus Perillae 10-14 gram Semen Persicaes 12-16 gram Radix Angelicae Sinensis 15-25 grams
Haematitum 4-6 gram Magnetitums 4-8 gram Poria 10-14 grams
Herba Menthae 3-6 grams;
Preparation process is as follows:
(1) gets the raw materials ready
(1) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, it is suitable to humidity to dry in the air, section, drying;
(2) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
(3) Semen Raphani: remove impurity, cleaning, drying, the time spent smashs to pieces;
(4) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
(5) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding is dried;
(6) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
(7) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(8) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(9) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section is dried;
(10) Massa Medicata Fermentata: get wheat bran and spread and spare in heat pot, the cigarette of having waited is poured Massa Medicata Fermentata into, fries to yellow, takes out, and sieves and removes wheat bran, cools;
(11) Fructus Jujubae: choose clean impurity, dry;
(12) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
(13) Fructus Amomi: choose decontamination and shell, smash to pieces;
(14) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
(15) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;
(16) Rhizoma Dioscoreae: choose clean impurity, be soaked in water and pull out and slightly dry in the air for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;
(17) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
(18) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
(19) Fructus Amomi Rotundus: choose clean impurity, the sieve scurf removing is smashed, or is peelled off shell, gets core and smashes usefulness;
(20) Fructus Crataegi: choose clean impurity, the sieve enucleation;
(21) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(22) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;
(23) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;
(24) Fructus Aurantii: remove flesh, nuclear, edulcoration slightly soaks, and pulls out, moistens softly, can pinch doubling as degree take hands, and section is dried;
(25) Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;
(26) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;
(27) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(28) Haematitum: get crude drug, remove impurity, cleaning, drying break into fragment or are ground into coarse powder;
(29) Magnetitum: choose decontamination, smash, sieve;
(30) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(31) Herba Menthae: choose clean impurity, remove undesirable root, leaf is trembled down in addition put first, then stem is sprayed clear water, run through rear cutting, dry, again with leaf and even;
(2) preparation
(1) Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Codonopsis, Semen Raphani, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Polygonati Odorati, Massa Medicata Fermentata, Fructus Jujubae, the Rhizoma Pinelliae, Fructus Amomi, Radix Glycyrrhizae, Fructus Hordei Germinatus, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Herba Asari, Fructus Amomi Rotundus, Fructus Crataegi, Radix Ophiopogonis, the Radix Aucklandiae, Rhizoma Zingiberis, Fructus Aurantii, Fructus Perillae, Semen Persicae, Radix Angelicae Sinensis, Haematitum, Magnetitum, Poria, the Herba Menthae crude drug of described weight are put into the container of boiling medicine, add for the first time 3 times of amounts of water, soak after 30 minutes, intense fire decocts boiling 20 minutes, with slow fire boiling 20 minutes and get final product, decoction liquor is poured in the container for the first time again;
(2) add 1.5 times of amounts of water for the second time, boil with high heat first, used slow fire boiling 20 minutes again, decoction liquor is poured in the container for the second time;
(3) twice decoction liquor carried out mixing and stirring, be divided into 3 doses and take.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Pseudobulbus Bletillae (Rhizoma Bletillae) 15 gram Radix Codonopsis 10 gram Semen Raphanis 15 grams
Pericarpium Citri Reticulatae 10 gram Cortex Magnoliae Officinalis 10 gram Endothelium Corneum Gigeriae Galli 10 grams
Radix Salviae Miltiorrhizae 15 gram Rhizoma Chuanxiongs 10 gram Rhizoma Polygonati Odorati 12 grams
The Massa Medicata Fermentata 9 gram Fructus Jujubaes 12 gram Rhizoma Pinelliaes 10 grams
Fructus Amomi 8 gram Radix Glycyrrhizaes 6 gram Fructus Hordei Germinatus 10 grams
Rhizoma Dioscoreae 10 gram Radix Et Rhizoma Rhei 10 gram Herba Asaris 12 grams
Fructus Amomi Rotundus 10 Keshan short, bristly hair or beards 6 gram Radix Ophiopogonis 8 grams
The Radix Aucklandiae 10 gram Rhizoma Zingiberiss 12 gram Fructus Aurantiis 12 grams
Fructus Perillae 12 gram Semen Persicaes 15 gram Radix Angelicae Sinensis 20 grams
Haematitum 5 gram Magnetitums 6 gram Poria 12 grams
Herba Menthae 4 grams;
Preparation process is as follows:
(1) gets the raw materials ready
(1) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, it is suitable to humidity to dry in the air, section, drying;
(2) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
(3) Semen Raphani: remove impurity, cleaning, drying, the time spent smashs to pieces;
(4) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
(5) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding is dried;
(6) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
(7) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(8) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(9) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section is dried;
(10) Massa Medicata Fermentata: get wheat bran and spread and spare in heat pot, the cigarette of having waited is poured Massa Medicata Fermentata into, fries to yellow, takes out, and sieves and removes wheat bran, cools;
(11) Fructus Jujubae: choose clean impurity, dry;
(12) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
(13) Fructus Amomi: choose decontamination and shell, smash to pieces;
(14) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
(15) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;
(16) Rhizoma Dioscoreae: choose clean impurity, be soaked in water and pull out and slightly dry in the air for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;
(17) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
(18) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
(19) Fructus Amomi Rotundus: choose clean impurity, the sieve scurf removing is smashed, or is peelled off shell, gets core and smashes usefulness;
(20) Fructus Crataegi: choose clean impurity, the sieve enucleation;
(21) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(22) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;
(23) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;
(24) Fructus Aurantii: remove flesh, nuclear, edulcoration slightly soaks, and pulls out, moistens softly, can pinch doubling as degree take hands, and section is dried;
(25) Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;
(26) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;
(27) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(28) Haematitum: get crude drug, remove impurity, cleaning, drying break into fragment or are ground into coarse powder;
(29) Magnetitum: choose decontamination, smash, sieve;
(30) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(31) Herba Menthae: choose clean impurity, remove undesirable root, leaf is trembled down in addition put first, then stem is sprayed clear water, run through rear cutting, dry, again with leaf and even;
(2) preparation
(1) Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Codonopsis, Semen Raphani, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Polygonati Odorati, Massa Medicata Fermentata, Fructus Jujubae, the Rhizoma Pinelliae, Fructus Amomi, Radix Glycyrrhizae, Fructus Hordei Germinatus, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Herba Asari, Fructus Amomi Rotundus, Fructus Crataegi, Radix Ophiopogonis, the Radix Aucklandiae, Rhizoma Zingiberis, Fructus Aurantii, Fructus Perillae, Semen Persicae, Radix Angelicae Sinensis, Haematitum, Magnetitum, Poria, the Herba Menthae crude drug of described weight are put into the container of boiling medicine, add for the first time 3 times of amounts of water, soak after 30 minutes, intense fire decocts boiling 20 minutes, with slow fire boiling 20 minutes and get final product, decoction liquor is poured in the container for the first time again;
(2) add 1.5 times of amounts of water for the second time, boil with high heat first, used slow fire boiling 20 minutes again, decoction liquor is poured in the container for the second time;
(3) twice decoction liquor carried out mixing and stirring, be divided into 3 doses and take.
3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:
(1) gets the raw materials ready
(1) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, it is suitable to humidity to dry in the air, section, drying;
(2) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
(3) Semen Raphani: remove impurity, cleaning, drying, the time spent smashs to pieces;
(4) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;
(5) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrape off rough bark after running through, clean, shredding is dried;
(6) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
(7) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(8) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(9) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section is dried;
(10) Massa Medicata Fermentata: get wheat bran and spread and spare in heat pot, the cigarette of having waited is poured Massa Medicata Fermentata into, fries to yellow, takes out, and sieves and removes wheat bran, cools;
(11) Fructus Jujubae: choose clean impurity, dry;
(12) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;
(13) Fructus Amomi: choose decontamination and shell, smash to pieces;
(14) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
(15) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;
(16) Rhizoma Dioscoreae: choose clean impurity, be soaked in water and pull out and slightly dry in the air for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;
(17) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
(18) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
(19) Fructus Amomi Rotundus: choose clean impurity, the sieve scurf removing is smashed, or is peelled off shell, gets core and smashes usefulness;
(20) Fructus Crataegi: choose clean impurity, the sieve enucleation;
(21) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(22) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;
(23) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;
(24) Fructus Aurantii: remove flesh, nuclear, edulcoration slightly soaks, and pulls out, moistens softly, can pinch doubling as degree take hands, and section is dried;
(25) Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;
(26) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;
(27) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(28) Haematitum: get crude drug, remove impurity, cleaning, drying break into fragment or are ground into coarse powder;
(29) Magnetitum: choose decontamination, smash, sieve;
(30) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(31) Herba Menthae: choose clean impurity, remove undesirable root, leaf is trembled down in addition put first, then stem is sprayed clear water, run through rear cutting, dry, again with leaf and even;
(2) preparation
(1) Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Codonopsis, Semen Raphani, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Polygonati Odorati, Massa Medicata Fermentata, Fructus Jujubae, the Rhizoma Pinelliae, Fructus Amomi, Radix Glycyrrhizae, Fructus Hordei Germinatus, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Herba Asari, Fructus Amomi Rotundus, Fructus Crataegi, Radix Ophiopogonis, the Radix Aucklandiae, Rhizoma Zingiberis, Fructus Aurantii, Fructus Perillae, Semen Persicae, Radix Angelicae Sinensis, Haematitum, Magnetitum, Poria, the Herba Menthae crude drug of described weight are put into the container of boiling medicine, add for the first time 3 times of amounts of water, soak after 30 minutes, intense fire decocts boiling 20 minutes, with slow fire boiling 20 minutes and get final product, decoction liquor is poured in the container for the first time again;
(2) add 1.5 times of amounts of water for the second time, boil with high heat first, used slow fire boiling 20 minutes again, decoction liquor is poured in the container for the second time;
(3) twice decoction liquor carried out mixing and stirring, be divided into 3 doses and take.
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| CN102835659B (en) * | 2012-08-22 | 2013-07-17 | 揭东县康明保健品有限公司 | Preparation method of intelligence-improving factor contained food for improving digestion, protecting intestines and supplementing nutrients |
| CN102935192B (en) * | 2012-11-26 | 2014-05-07 | 龚定军 | Medicament for treating gastric diseases |
| CN103751704A (en) * | 2013-12-19 | 2014-04-30 | 青岛友铭辰生物技术有限公司 | Traditional Chinese medicinal tablet for treating infantile malnutrition and preparation method thereof |
| CN103893726A (en) * | 2014-03-31 | 2014-07-02 | 袁志贤 | Traditional Chinese medicine preparation for treating chronic gastritis and preparation method thereof |
| CN104027620A (en) * | 2014-05-15 | 2014-09-10 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine composition for treating acute gastroenteritis |
| CN104161984A (en) * | 2014-08-29 | 2014-11-26 | 广西博士海意信息科技有限公司 | Medicament for treating gastrosis |
| CN104398916A (en) * | 2014-10-31 | 2015-03-11 | 贵州黄平美娘冲民族服饰有限公司 | Stomach strengthening and food digestion composition for pigs |
| CN104435905A (en) * | 2014-11-25 | 2015-03-25 | 范影 | Traditional Chinese medicine formula for coordinating intestines and stomach |
| CN104940705A (en) * | 2015-07-16 | 2015-09-30 | 王乾林 | Traditional Chinese medicine for treating child gastrointestinal tract flatulence |
| CN105125784A (en) * | 2015-09-11 | 2015-12-09 | 李传义 | Traditional Chinese medicine for regulating qi and preparation method thereof |
| CN106806492A (en) * | 2015-12-01 | 2017-06-09 | 戚佳奉 | A kind of decocting liquid for treating stomachache |
| CN105768070A (en) * | 2016-03-10 | 2016-07-20 | 河南亿家兴生物科技有限公司 | Functional nutritional food for regulating intestines and stomach |
| CN107348340A (en) * | 2017-08-18 | 2017-11-17 | 芜湖飞越食品有限公司 | It is a kind of to be used to treat caramel watermelon seed of gasteremphraxis and preparation method thereof |
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| CN101416732A (en) * | 2007-10-22 | 2009-04-29 | 张学忠 | Kylin digestion-promoting syrup |
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