CN102106991B

CN102106991B - A kind of for the medicine after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma

Info

Publication number: CN102106991B
Application number: CN201110027563.6A
Authority: CN
Inventors: 臧国敬; 陈学波; 段永英
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-01-20
Filing date: 2011-01-20
Publication date: 2015-08-26
Anticipated expiration: 2031-01-20
Also published as: CN102106991A

Abstract

A kind of for the medicine after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma, it is made up of by weight raw material: Radix Codonopsis 4.2-12.5%, Rhizoma Atractylodis 2.7-6.5%, Rhizoma Atractylodis Macrocephalae 2.7-6.5%, Polyporus 4.2-12.5%, Poria 4.2-12.5%, Rhizoma Pinelliae 2.64.5%, Pericarpium Citri Reticulatae 4-6.7%, Radix Bupleuri 2.6-4.5%, Radix Paeoniae Alba 4.2-12.5%, Radix Angelicae Sinensis 4.2-12.5%, Semen Coicis 4.2-12.5%, Herba Artemisiae Scopariae 4.2-12.5%, Cortex Moutan 2.7-6.5%, Radix Curcumae 2.7-6.5%, Endothelium Corneum Gigeriae Galli 2.7-6.5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 8.4-18.7%, Radix Glycyrrhizae 1.6-2.7%, thus, can to the liver function-protecting of patient, heighten the effect of a treatment, improve quality of life, extend patients ' lives, alleviate household economy burden, be particularly suitable for the use after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma.

Description

A kind of for the medicine after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma

Technical field:

The present invention relates to a kind of medicine for the treatment of mid and late liver cancer, particularly a kind of hepatic arterial chemoembolization is carried out to mid and late liver cancer patient after the Chinese herbal medicine taken.

Background technology:

Hepatocarcinoma is a kind of modal malignant tumor in digestive system, recent sickness rate ascendant trend is obvious, mostly adopt hands art in the treatment, get involved, expectant treatment, along with the development of society, interventional therapy becomes the first-selection of people, a kind of Wicresoft mainly due to interventional therapy, the hands art that safety is high, the degree of personal injury's evil is less, but, the liver function injury of interventional therapy repeatedly to patient is larger, the financial burden of the spirit of patient and quality of life and family has great impact, at present, can only be treated by Western medicine after carrying out the patient of interventional therapy, particularly postoperative 6-24 hour, the muscle power of patient is very empty, the healthy energy that patient can be made empty is more empty, anticancer power declines further, for the relapse and metastasis of remaining cancer poison provides advantage, the cost of Western medicine is higher, the burden of patient is heavier, simultaneously, Western medicine has certain side effect, long-term taking, certain untoward reaction can also be produced, now, China carries out hepatoprotective after also not having one to utilize Chinese herbal medicine to carry out hepatic arterial chemoembolization to mid and late liver cancer patient.

Invention task:

Object of the present invention be exactly a kind of liver function-protecting to patient will be provided, heighten the effect of a treatment, improve quality of life, extend patients ' lives, alleviate the treatment Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma of household economy burden after medicine.

The object of the present invention is achieved like this: a kind ofly treat the medicine after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma, it is characterized in that it is made up of by weight raw material: Radix Codonopsis 4.2-12.5%, Rhizoma Atractylodis 2.7-6.5%, Rhizoma Atractylodis Macrocephalae 2.7-6.5%, Polyporus 4.2-12.5%, Poria 4.2-12.5%, Rhizoma Pinelliae 2.6-4.5%, Pericarpium Citri Reticulatae 4-6.7%, Radix Bupleuri 2.6-4.5%, Radix Paeoniae Alba 4.2-12.5%, Radix Angelicae Sinensis 4.2-12.5%, Semen Coicis 4.2-12.5%, Herba Artemisiae Scopariae 4.2-12.5%, Cortex Moutan 2.7-6.5%, Radix Curcumae 2.7-6.5%, Endothelium Corneum Gigeriae Galli 2.7-6.5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 8.4-18.7%, Radix Glycyrrhizae 1.6-2.7%.

Medicine after treatment Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma of the present invention, it is made up of by weight raw material: Radix Codonopsis 4.9-10%, Rhizoma Atractylodis 3.3-5%, Rhizoma Atractylodis Macrocephalae 3.3-5%, Polyporus 4.9-10%, Poria 4.9-10%, Rhizoma Pinelliae 3-3.5%, Pericarpium Citri Reticulatae 4.5-5%, Radix Bupleuri 3-3.5%, Radix Paeoniae Alba 4.9-10%, Radix Angelicae Sinensis 4.9-10%, Semen Coicis 4.9-10%, Herba Artemisiae Scopariae 4.9-10%, Cortex Moutan 3.3-5%, Radix Curcumae 3.3-5%, Endothelium Corneum Gigeriae Galli 3.3-5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-14.8%, Radix Glycyrrhizae 1.8-2.2%.

Medicine after treatment Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma of the present invention, it also comprises following raw material by weight: Herba Artemisiae Annuae 4.9-10%, Radix Cynanchi Atrati 3.3-5%.

Medicine after treatment Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma of the present invention, it also comprises following raw material by weight: Fructus Amomi 3-3.5%%, Pericarpium Arecae 9.5-10.5%, Semen Raphani 9.5-10.5%.

Medicine after treatment Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma of the present invention, it also comprises following raw material by weight: Radix Rubiae 4.5-5%, Herba Agrimoniae 9.5-10.5%, Cacumen Platycladi 4.5-5%.

Medicine after treatment Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma of the present invention, to be made as decoction, also can to make in pill, capsule, medicamental pulverata electuary.

Hepatocarcinoma supplies overall tumor body primarily of the tumor vasa vasorum of Branch of hepatic artery, in the tumor neighboring area that growth of tumour cell is active, then there is many branch of portal vein simultaneously, when there is tumor in liver, its tumor feeding obtains blood by ramus anastomoticus from contiguous tremulous pulse and supplies, more than the blood supply 90%-95% of hepatocarcinoma is from Hepatic artery, therefore by hepatic artery catheterization administration, medicine can be made directly to enter liver cancer tissue, substantially increase the drug level of local, cell is is farthest killed and wounded, partner treatment is carried out by Chinese herbal medicine after intervention, play the effect of attenuation synergistic, can avoid feeling sick, vomiting, degradation digestive tract side effects under appetite, the bone marrow depression reaction caused by chemotherapy can be alleviated, the leukocyte that may occur can be avoided, platelet decline phenomenon, strengthen the protection to liver function, avoid getting involved medicine and directly act on liver and the infringement of liver function that causes, because Chinese herbal medicine has the effect of killing tumor, tumor suppression, thus, cancer poison can be killed to greatest extent, reduce the recurrence probability of cancer poison, use Chinese medicine to change cancer cell characteristics, thus play the effect of Tumor suppression transfer.

Radix Codonopsis: invigorating middle warmer, QI invigorating, promotes the production of body fluid, and controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis; The present invention is mainly used in QI invigorating training unit;

Rhizoma Atractylodis: meridian distribution of property and flavor is pungent, bitter, temperature.Return spleen, stomach, Liver Channel, drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia; The present invention is mainly used in damp eliminating and reduces phlegm spleen invigorating;

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature, return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement; The present invention is mainly used in QI invigorating training unit;

Polyporus: property is put down, sweet in the mouth, and promoting diuresis to eliminate damp pathogen, cures mainly dysuria, drenches the diseases such as drop burning pain, edema, and has antitumaous effect; The present invention is mainly used in damp eliminating and reduces phlegm spleen invigorating;

Poria: sweet in the mouth, light, property are put down, and be used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect; The present invention is mainly used in QI invigorating training unit;

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, cures mainly cough with asthma abundant expectoration, vomiting regurgitation, and feeling of oppression and fullness in the chest and epigastrium headache is dizzy, uneasy sleeping at night, gall subcutaneous nodule, swollen ulcer drug; The present invention is mainly used in damp eliminating and reduces phlegm spleen invigorating;

Pericarpium Citri Reticulatae: tool regulating QI and lowering the adverseness, adjust in appetizing, drying dampness to eliminate phlegm merit, cure mainly dirty inverse, the difficulty in urination and defecation of stagnation of QI in spleen and stomach dampness, chest and diaphragm full vexed, abdominal distention, anorexia, vomiting, lung qi retardance, cough with copious phlegm, also control acute mastitis from the beginning of; The present invention is mainly used in damp eliminating and reduces phlegm spleen invigorating;

Radix Bupleuri: nature and flavor: bitter flat, Gui Jing, enter liver, gallbladder meridian, function: deliver, bring down a fever, soothing the liver, resolving depression, yang invigorating, cures mainly cat fever, alternate attack of chill and fever, malaria, side of body distending pain, menoxenia, treating SHAO YANG disease by mediation, soothing liver-QI stomach function regulating, ascending up spleen-Qi and Yang.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse, invasion of the blood-chamber by heat; The present invention is mainly used in dispersing liver and promoting blood circulation;

The Radix Paeoniae Alba: nature and flavor picric acid, cool, nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia; The present invention is mainly used in easing the affected liver and nourishes blood;

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; The present invention is mainly used in easing the affected liver and nourishes blood;

Semen Coicis: nature and flavor are cool in nature, sweet in the mouth, light, spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, can be used for treatment edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen; The present invention is mainly used in damp eliminating and reduces phlegm spleen invigorating;

Herba Artemisiae Scopariae: bitter, pungent, is slightly cold, and returns spleen, stomach, liver, gallbladder meridian, clearing away damp-heat, jaundice eliminating subcutaneous ulcer, for jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis. pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating; The present invention is mainly used in dispersing liver and promoting blood circulation;

Cortex Moutan: heat clearing away; Promoting blood circulation to remove blood stasis, the main epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The pathogenic bacteria later stage brimful of tears, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia; The present invention is mainly used in dispersing liver and promoting blood circulation;

Radix Curcumae: pungent, bitter, cold, return liver, the heart, lung meridian, regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine; The present invention is mainly used in dispersing liver and promoting blood circulation;

Endothelium Corneum Gigeriae Galli: sweet, flat, puckery, spleen channel, strengthening the spleen to promote digestion, arresting seminal emission, eliminating mass fossil, main dyspepsia, dysentery, infantile malnutrition, the seminal emission enuresis, urinary system calculus, cholelithiasis, lump in the abdomen amenorrhea; The present invention is mainly used in stomach function regulating and helps digestion;

JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): be Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), this three tastes medicine all has the stagnant function of good removing food stagnancyization, but has features different separately, and Fructus Hordei Germinatus (parched to brown) has the effect of good digestible starch group food; Fructus Crataegi (parched to brown) is good at treating meat or greasy too much caused dyspepsia; Massa Medicata Fermentata (parched to brown) is then beneficial to digestion rice and flour food, and three medicines share, and can strengthen digestive function significantly; The present invention is mainly used in stomach function regulating and helps digestion;

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong; The present invention is mainly used in QI invigorating training unit;

Herba Artemisiae Annuae: bitter, acrid, cold, returns liver, gallbladder meridian, clear deficiency-heat thoroughly, and removing heat from blood removes and steams, expelling summer-heat, preventing the attack (or recurrence) of malaria; The present invention is mainly used in reducing the asthenic fever;

Radix Cynanchi Atrati: bitter in the mouth, salty, cold in nature, cure mainly warm, fever of the body macule, hectic fever hectic fever due to YIN-deficiency, cough due to lung-heat, puerperal fidgets due to deficiency, pyretic stranguria, stranguria with blood, laryngopharynx swelling and pain, sore and toxic, venom; The present invention is mainly used in reducing the asthenic fever;

Fructus Amomi: meridian distribution of property and flavor: pungent, temperature, returns spleen, stomach, kidney channel, and cure mainly removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive, for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement; The present invention is mainly used in relieving distension of regulating the flow of vital energy;

Pericarpium Arecae: acrid in the mouth, slightly warm in nature, returns spleen, stomach, large intestine, small intestine meridian, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence, and for retention of damp leading to blockage of QI, breast abdominal distention is vexed, defecates not well, edema, beriberi, dysuria; The present invention is mainly used in relieving distension of regulating the flow of vital energy;

Semen Raphani:: property is put down, acrid in the mouth, sweet, return lung, spleen, stomach warp, help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots, enter spleen, stomach, lung meridian, can help digestion de-swelling, and effect is remarkable, have the title of " rush wall fall wall ", clinical habit is used for the treatment of real (food, wet, stagnant) disease; The present invention is mainly used in relieving distension of regulating the flow of vital energy;

Radix Rubiae: bitter, returns Liver Channel, removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow, and antitussive is eliminated the phlegm, for spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling, hemorrhagic illness can be treated, chronic tracheitis, chronic diarrhea, rheumatic arthritis, treatment soft tissue injury, treatment leukopenia; The present invention is mainly used in cooling blood for hemostasis;

Herba Agrimoniae: bitter, puckery, flat, GUIXIN, Liver Channel, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, for hemoptysis, spits blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia; The present invention is mainly used in cooling blood for hemostasis;

Cacumen Platycladi: bitter, puckery, cold, return lung, liver, spleen channel, cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair; The present invention is mainly used in cooling blood for hemostasis.

All medicine compatibilities above, play invigorating the spleen and regulating the stomach with angry blood, eliminate the phlegm and invigorate blood circulation stimulate the menstrual flow tunnel, tonify without causing stagnation, eliminating evil effect of not hindering healthy energy, and make simple, taking convenience, have no side effect, cheap.

The present invention has good result by clinical trial, all adopts Seldinger technology percutaneous femoral artery puncture to two group of 60 routine middle and terminal cancer patient, conduit is inserted Hepatic artery and feeding artery carries out chemoembolization; A group is simple hepatic arterial chemoembolization, and B group carries out treatment by Chinese herbs for postoperative, and two groups are compared in table 1,2

Table 1: survival rate situation

	0.5 year	1 year	2 years	3 years
					A group	90.5％	80.4％	45％	20.1％
B group	96％	86.5％	68.2％	35.5％

Table 2: quality of life condition (in life cycle symptom occurrence rate)

	Stomachache	Heating	Symptom of digestive tract	Other
					A group	22.6％	19.9％	69.9％	38.8％
B group	11.6％	3％	6％

Can be found out by above-mentioned two tables, the survival rate of B group patient is apparently higher than A group, and the survival rate of especially the 3rd year, through statistics X ²inspection, shows notable difference (p < 005), the curative effect that the treatment of Chinese medicine is of value to long-term is described; Quality of life aspect, B group patient also apparently higher than A group, and statistically have notable difference (p < 005), illustrate that the patient of Chinese medicine partner treatment can obtain good life quality; Other refer to other factors affecting patients ' life quality, as bad in weak, emotional lability, sleep etc.; By the treatment of Chinese herbal medicine, still there are 12 routine patients survive after 3 years, current stable disease.

Detailed description of the invention:

Embodiment 1: to make an auxiliary medicine agent, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, 15 grams, Poria, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 15 grams, Radix Curcumae 10 grams, Endothelium Corneum Gigeriae Galli 10 grams, each 10 grams of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 6 grams, Radix Glycyrrhizae; First mixed by above-mentioned raw material and be put in medicinal cupping, then put 3, Rhizoma Zingiberis Recens, then in medicinal cupping, inject water, water wants dipped medical herbs, and soak and decoct after 20-30 minute, decoct 2 times altogether, extracting juice 400-500 liter, within 1-2 days, take, this formula is suitable for all patients.

Embodiment 2: to make an auxiliary medicine agent, gets Radix Codonopsis 15 grams, Rhizoma Atractylodis 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Polyporus 30 grams, 30 grams, Poria, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 15 grams, Radix Angelicae Sinensis 20 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 15 grams, Cortex Moutan 10 grams, Radix Curcumae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams, each 15 grams of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 6 grams, Radix Glycyrrhizae, Herba Artemisiae Annuae 30 grams, Radix Cynanchi Atrati 15 grams; Manufacture method is with embodiment 1, and this formula is suitable for the patient had a low fever.

Embodiment 3: to make an auxiliary medicine agent, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, 15 grams, Poria, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 10 grams, Radix Curcumae 15 grams, Endothelium Corneum Gigeriae Galli 10 grams, each 10 grams of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 6 grams, Radix Glycyrrhizae, Fructus Amomi 10 grams, Pericarpium Arecae 30 grams, Semen Raphani 30 grams; Manufacture method is with embodiment 1, and this formula is suitable for the patient of abdominal distention.

Embodiment 4: to make an auxiliary medicine agent, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, 15 grams, Poria, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 30 grams, Semen Coicis 15 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 15 grams, Radix Curcumae 10 grams, Endothelium Corneum Gigeriae Galli 10 grams, each 10 grams of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 6 grams, Radix Glycyrrhizae, 15 grams, Radix Rubiae, Herba Agrimoniae 30 grams, Cacumen Platycladi 15 grams; Manufacture method is with embodiment 1, and this formula is suitable for the patient of tooth epistaxis.

Embodiment 5: to make an auxiliary medicine, gets Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 30 grams, 30 grams, Poria, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 15 grams, Cortex Moutan 10 grams, Radix Curcumae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams, each 15 grams of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 6 grams, Radix Glycyrrhizae; If patient haves a low fever add Herba Artemisiae Annuae 15 grams, Radix Cynanchi Atrati 10 grams again; If patient's abdominal distention adds Fructus Amomi 10 grams, Pericarpium Arecae 30 grams, Semen Raphani 30 grams again; If patient's tooth epistaxis adds 15 grams, Radix Rubiae, Herba Agrimoniae 30 grams, Cacumen Platycladi 15 grams again; First above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker to dry, then carry out grinding to form graininess, then with 100 object sieves, ground raw material is sieved, the medicine that granule is little filters out, for future use, what granule was large carries out grinding into powder sieving again, finally reaches the object of sieving; Then 1 kilogram of Mel is put into the refining of pot low baking temperature, solidifying as maltosemalt sugar shape, that stirs does not make Jiao; Finally refined honey is mixed with above-mentioned medicamental pulverata and rubs by evenly, place about half an hour, again rub by, make the honeyed pill of about 6 grams, point within 1-2 days, to take.

Embodiment 6, to make an auxiliary medicine, get Radix Codonopsis 30 grams, Rhizoma Atractylodis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Polyporus 15 grams, 15 grams, Poria, the Rhizoma Pinelliae 10 grams, Pericarpium Citri Reticulatae 15 grams, Radix Bupleuri 10 grams, the Radix Paeoniae Alba 30 grams, Radix Angelicae Sinensis 15 grams, Semen Coicis 30 grams, Herba Artemisiae Scopariae 30 grams, Cortex Moutan 15 grams, Radix Curcumae 10 grams, Endothelium Corneum Gigeriae Galli 10 grams, each 10 grams of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 6 grams, Radix Glycyrrhizae; If patient haves a low fever add Herba Artemisiae Annuae 15 grams, Radix Cynanchi Atrati 10 grams again; If patient's abdominal distention adds Fructus Amomi 10 grams, Pericarpium Arecae 30 grams, Semen Raphani 30 grams again; If patient's tooth epistaxis adds 15 grams, Radix Rubiae, Herba Agrimoniae 30 grams, Cacumen Platycladi 15 grams again; First above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker to dry, then carry out grinding to form graininess, then with 100 object sieves, ground raw material is sieved, the medicine that granule is little filters out, for future use, what granule was large carries out grinding into powder sieving again, finally reaches the object of sieving; Finally pack in units of 6 grams, divide and take for 1-2 days.

Embodiment 7: to make an auxiliary medicine, raw-material proportioning is with embodiment 6; Manufacture method is last as different from Example 6 to be incapsulated with 0.5 gram, divides and takes for 1-2 days.

Claims

1. for the medicine after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma, it is characterized in that it is made up of by weight following raw material: Radix Codonopsis 4.2-12.5%, Rhizoma Atractylodis 2.7-6.5%, Rhizoma Atractylodis Macrocephalae 2.7-6.5%, Polyporus 4.2-12.5%, Poria 4.2-12.5%, Rhizoma Pinelliae 2.6-4.5%, Pericarpium Citri Reticulatae 4-6.7%, Radix Bupleuri 2.6-4.5%, Radix Paeoniae Alba 4.2-12.5%, Radix Angelicae Sinensis 4.2-12.5%, Semen Coicis 4.2-12.5%, Herba Artemisiae Scopariae 4.2-12.5%, Cortex Moutan 2.7-6.5%, Radix Curcumae 2.7-6.5%, Endothelium Corneum Gigeriae Galli 2.7-6.5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 8.4-18.7%, Radix Glycyrrhizae 1.6-2.7%.

2. according to claim 1 a kind of for the medicine after Transcatheter Arterial Chemoembolization On Advanced Hepatocellular Carcinoma, it is characterized in that it is made up of by weight following raw material: Radix Codonopsis 4.9-10%, Rhizoma Atractylodis 3.3-5%, Rhizoma Atractylodis Macrocephalae 3.3-5%, Polyporus 4.9-10%, Poria 4.9-10%, Rhizoma Pinelliae 3-3.5%, Pericarpium Citri Reticulatae 4.5-5%, Radix Bupleuri 3-3.5%, Radix Paeoniae Alba 4.9-10%, Radix Angelicae Sinensis 4.9-10%, Semen Coicis 4.9-10%, Herba Artemisiae Scopariae 4.9-10%, Cortex Moutan 3.3-5%, Radix Curcumae 3.3-5%, Endothelium Corneum Gigeriae Galli 3.3-5%, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-14.8%, Radix Glycyrrhizae 1.8-2.2%.