CN101028392B - Chinese medicine for treating hyperlipemia - Google Patents
Chinese medicine for treating hyperlipemia Download PDFInfo
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- CN101028392B CN101028392B CN200710065482A CN200710065482A CN101028392B CN 101028392 B CN101028392 B CN 101028392B CN 200710065482 A CN200710065482 A CN 200710065482A CN 200710065482 A CN200710065482 A CN 200710065482A CN 101028392 B CN101028392 B CN 101028392B
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Abstract
A Chinese medicine for treating hyperlipemia is prepared from more than 10 Chinese-medicinal materials including oriental wormwood, ganoderma, umbellate pore-fungus, astragalus root, etc.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine for the treatment of hyperlipemia, is that a kind of hyperlipemia for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Blood fat is the general name of lipid in blood plasma or the serum, mainly contains cholesterol, triglyceride, phosphide, free fatty etc., and the lipid content in the blood surpasses normal concentration and is called hyperlipemia.Because blood plasma lipide is liposoluble substance, in blood,, become the water miscible complex whole body that could turn round, so claim hyperlipoproteinemia again with protein bound.
The lipid cholesterol meansigma methods has remarkable ascendant trend in the population of China, and its reason is relevant with the difference of living standard diet nutritional composition height.The male is higher than the women, and the big city resident is higher, and peasant, fisherman are lower.All things considered, with westerner's faciation such as America and Europe than still belonging to reduced levels.Raising along with living standards of the people, some undesired life style, as high sugar, high Animal fat meals, not or few motion, smoking, heavy drinking, weight increase etc., be the important foundation that causes dysbolism of blood fat, also be some risk factors that cause coronary heart disease.
The traditional Chinese medical science thinks that hyperlipemia mainly is divided into: dialectical the executing of disease type such as retention of damp-heat in the interior, insufficiency of the spleen leading to overabundance of dampness, the turbid retardance of expectorant, qi depression to blood stasis, deficiency of kidney-essence, hyperactivity of YANG due to deficiency of YIN are controlled, and evident in efficacy.The method of western medical treatment primary disease is a lot, but great majority can only reach recent clinical effectiveness, and can not prevent recurrence, and has toxic and side effects in various degree.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese patent medicine for the treatment of hyperlipemia, and have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Herba Patriniae of 1.5～6 portions of Ganodermas of Herba Artemisiae Scopariae
1.5～6 parts of 3～12 parts of Fructus Crataegi of 1.5～6 parts of Radixs Astragali of Polyporus
0.1～2 part of 1.5～6 parts of Radix Et Rhizoma Rhei of 1.5～6 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
1.5～6 parts of 1～4 part of Pericarpium Citri Reticulataes of 0.1～2 part of Radix Bupleuri of Semen Persicae
The weight proportion of each raw material of optimization formula of the present invention is:
2.5～3.5 parts of 2.5～3.5 parts of Herba Patriniae of 2.5～3.5 portions of Ganodermas of Herba Artemisiae Scopariae
2.5～3.5 parts of 4.0～8.0 parts of Fructus Crataegi of 2.5～3.5 parts of Radixs Astragali of Polyporus
0.5～1.5 part of 2.5～3.5 parts of Radix Et Rhizoma Rhei of 2.5～3.5 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
2.5～3.5 parts of 1.5～2.5 parts of Pericarpium Citri Reticulataes of 0.5～1.5 part of Radix Bupleuri of Semen Persicae
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of 3 parts of Herba Patriniae of 3 portions of Ganodermas of Herba Artemisiae Scopariae
3 parts of 6 parts of Fructus Crataegi of 3 parts of Radixs Astragali of Polyporus
1 part of 3 parts of Radix Et Rhizoma Rhei of 3 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
3 parts of 2 parts of Pericarpium Citri Reticulataes of 1 part of Radix Bupleuri of Semen Persicae
Drug action mechanism among the present invention is as follows:
Herba Artemisiae Scopariae nature and flavor hardship, suffering are slightly cold.Return spleen, stomach, liver, gallbladder meridian.Has clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer.Can treat the jaundice oliguria, the eczema pruritus; Infectious jaundice type hepatitis etc.(the 192nd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The Ganoderma nature and flavor are sweet, and are flat.Return lung, heart spleen channel.It is strong to have QI invigorating, the effect of tranquilizing by nourishing the heart.It is thin and weak to treat asthenia, inappetence, cardiopalmus, insomnia, dizziness, spiritlessness and weakness, chronic cough asthma, coronary heart disease, hypertension, hyperlipidemia, pneumosilicosis etc.(the 1651st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Herba Patriniae nature and flavor hardship, flat.Return liver, stomach, large intestine channel.Effect with heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Can treat acute appendicitis, dysentery, leucorrhea with red and white discharge, puerperal be retarded by silt stomachache, conjunctival congestion and swelling pain, carbuncle scabies, appendicitis, enteritis, eye conjunctivitis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 801st page).
The Polyporus nature and flavor are sweet, light, flat.Return spleen, kidney, urinary bladder channel.Have diuresis eliminating dampness by diuresis, anticancer effect.Can treat dysuria, edema distension, beriberi, urinary system infection, diarrhoea, stranguria with turbid discharge, leukorrhagia etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1122nd page).
Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.That can treat that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1074th page).
Fructus Crataegi property of medicine acid, sweet, tepor.Return spleen, stomach, Liver Channel.Has promoting digestion and invigorating the stomach, the effect of circulation of qi promoting dissipating blood stasis.Can treat eating accumulation, abdominal distention, diarrhea dysentery, amenorrhea, puerperal abdonimal pain, lochiorrhea, hernia or painful and swollen testis, hyperlipidemia etc.(the 226th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Alismatis nature and flavor are sweet, cold.Return kidney, urinary bladder channel.Has diuresis, the effect of clearing away damp-heat.Can treat dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia etc.(the 184th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.Can treat menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris etc.(the 57th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
Semen Persicae property of medicine hardship, sweet, mild toxicity.GUIXIN, liver, large intestine channel.Has blood circulation promoting and blood stasis dispelling, the effect of loosening bowel to relieve constipation.Can treat dysmenorrhea, amenorrhea due to stagnation of blood, the stagnant stomachache of the stasis of blood in puerperal ， mass in the abdomen caking, traumatic injury, swelling and pain due to blood stasis, lung abscess, acute appendicitis, dryness of the intestine constipation etc.(the 2542nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Radix Bupleuri nature and flavor hardship, be slightly cold.Return liver, gallbladder meridian.Effect with reconciling superficies and interior, soothing the liver, yang invigorating.Can treat alternate attack of chill and fever, fullness in the chest and hypochondriac pain, deafness, headache and dizziness, malaria, dysentery proctoptosis, menoxenia, uterine prolapse, flu, upper respiratory tract infection, hepatitis, cholecystitis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 1004th page).
Radix Et Rhizoma Rhei property of medicine hardship, cold.Return stomach, large intestine, liver, spleen channel.Have attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, antidotal effect.Can treat the food stagnation constipation, the accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria; Conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting; Spit blood, spitting of blood, epistaxis is had blood in stool, hematuria; Blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal ， lumps in the chest and abdomen, traumatic injury; Pyretic toxicity carbuncle and ulcer, erysipelas is scalded etc.(the 141st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Pericarpium Citri Reticulatae nature and flavor hardship, suffering, temperature.Return lung, spleen channel.Has regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm.Can treat fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm etc.(the 149th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Herba Artemisiae Scopariae, Ganoderma, Polyporus, the Radix Astragali and Herba Patriniae, is ministerial drug with Fructus Crataegi, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Semen Persicae and Radix Bupleuri, is adjuvant with Radix Et Rhizoma Rhei and Pericarpium Citri Reticulatae.All medicine phases and common tool regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm, the treatment hyperlipemia has determined curative effect, has no side effect taking convenience, cheap characteristics.
Chinese patent medicine of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese patent medicine of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferred Chinese patent medicine is a peroral dosage form, as: tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese patent medicine is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment hyperlipemia of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention not only can effectively treat hyperlipemia, and the prevention of hyperlipemia is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment hyperlipemia
As follows through clinical test results; Treatment hyperlipidemia patient 28 examples.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 15 examples and account for 53.5%, 11 examples that take a turn for the better account for 39.2%, and more 2 examples do not account for 7.1%, and total effective rate reaches 92.9%.After three course of therapy, indexs such as patient's cholesterol, triglyceride, phosphide, free fatty all have decline, and patient do not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
3 parts of 3 parts of Herba Patriniae of 3 portions of Ganodermas of Herba Artemisiae Scopariae
3 parts of 6 parts of Fructus Crataegi of 3 parts of Radixs Astragali of Polyporus
1 part of 3 parts of Radix Et Rhizoma Rhei of 3 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
3 parts of 2 parts of Pericarpium Citri Reticulataes of 1 part of Radix Bupleuri of Semen Persicae
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
3 parts of 3 parts of Herba Patriniae of 3 portions of Ganodermas of Herba Artemisiae Scopariae
3 parts of 6 parts of Fructus Crataegi of 3 parts of Radixs Astragali of Polyporus
1 part of 3 parts of Radix Et Rhizoma Rhei of 3 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
3 parts of 2 parts of Pericarpium Citri Reticulataes of 1 part of Radix Bupleuri of Semen Persicae
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
3 parts of 3 parts of Herba Patriniae of 3 portions of Ganodermas of Herba Artemisiae Scopariae
3 parts of 6 parts of Fructus Crataegi of 3 parts of Radixs Astragali of Polyporus
1 part of 3 parts of Radix Et Rhizoma Rhei of 3 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
3 parts of 2 parts of Pericarpium Citri Reticulataes of 1 part of Radix Bupleuri of Semen Persicae
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.
Claims (3)
1. Chinese patent medicine for the treatment of hyperlipemia is characterized in that it is made by following raw materials by weight proportions:
1.5～6 parts of 1.5～6 parts of Herba Patriniae of 1.5～6 portions of Ganodermas of Herba Artemisiae Scopariae
1.5～6 parts of 3～12 parts of Fructus Crataegi of 1.5～6 parts of Radixs Astragali of Polyporus
0.1～2 part of 1.5～6 parts of Radix Et Rhizoma Rhei of 1.5～6 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
1.5～6 parts of 1～4 part of Pericarpium Citri Reticulataes of 0.1～2 part of Radix Bupleuri of Semen Persicae.
2. a kind of Chinese patent medicine for the treatment of hyperlipemia according to claim 1, wherein the weight proportion of each crude drug is:
2.5～3.5 parts of 2.5～3.5 parts of Herba Patriniae of 2.5～3.5 portions of Ganodermas of Herba Artemisiae Scopariae
2.5～3.5 parts of 4.0～8.0 parts of Fructus Crataegi of 2.5～3.5 parts of Radixs Astragali of Polyporus
0.5～1.5 part of 2.5～3.5 parts of Radix Et Rhizoma Rhei of 2.5～3.5 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
2.5～3.5 parts of 1.5～2.5 parts of Pericarpium Citri Reticulataes of 0.5～1.5 part of Radix Bupleuri of Semen Persicae.
3. a kind of Chinese patent medicine for the treatment of hyperlipemia according to claim 1, wherein the weight proportion of each crude drug is:
3 parts of 3 parts of Herba Patriniae of 3 portions of Ganodermas of Herba Artemisiae Scopariae
3 parts of 6 parts of Fructus Crataegi of 3 parts of Radixs Astragali of Polyporus
1 part of 3 parts of Radix Et Rhizoma Rhei of 3 parts of Radix Salviae Miltiorrhizaes of Rhizoma Alismatis
3 parts of 2 parts of Pericarpium Citri Reticulataes of 1 part of Radix Bupleuri of Semen Persicae.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710065482A CN101028392B (en) | 2007-04-16 | 2007-04-16 | Chinese medicine for treating hyperlipemia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710065482A CN101028392B (en) | 2007-04-16 | 2007-04-16 | Chinese medicine for treating hyperlipemia |
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| Publication Number | Publication Date |
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| CN101028392A CN101028392A (en) | 2007-09-05 |
| CN101028392B true CN101028392B (en) | 2010-05-19 |
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| CN200710065482A Expired - Fee Related CN101028392B (en) | 2007-04-16 | 2007-04-16 | Chinese medicine for treating hyperlipemia |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103110849A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine pill for treating hyperlipidemia caused by stagnation of phlegm-dampness |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686273A (en) * | 2005-04-18 | 2005-10-26 | 张静 | Theory and medicine for treating high blood fat, fatty liver, liver fibrosis and preparation method |
| CN1850217A (en) * | 2006-01-28 | 2006-10-25 | 吉林敖东药业集团延吉股份有限公司 | Compounded preparation for treating fatty liver and preparing method |
| CN1857691A (en) * | 2006-04-13 | 2006-11-08 | 贵州信邦制药股份有限公司 | Lipid-lowering and toxin expelling preparation and its preparing process |
| CN1907462A (en) * | 2006-08-07 | 2007-02-07 | 张庆存 | Traditional Chinese medicine composition for treating hepatitis and fatty liver |
-
2007
- 2007-04-16 CN CN200710065482A patent/CN101028392B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686273A (en) * | 2005-04-18 | 2005-10-26 | 张静 | Theory and medicine for treating high blood fat, fatty liver, liver fibrosis and preparation method |
| CN1850217A (en) * | 2006-01-28 | 2006-10-25 | 吉林敖东药业集团延吉股份有限公司 | Compounded preparation for treating fatty liver and preparing method |
| CN1857691A (en) * | 2006-04-13 | 2006-11-08 | 贵州信邦制药股份有限公司 | Lipid-lowering and toxin expelling preparation and its preparing process |
| CN1907462A (en) * | 2006-08-07 | 2007-02-07 | 张庆存 | Traditional Chinese medicine composition for treating hepatitis and fatty liver |
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