CN100473401C - Chinese medicine preparation for preventing and treating cerebral thrombus and sequel thereof - Google Patents
Chinese medicine preparation for preventing and treating cerebral thrombus and sequel thereof Download PDFInfo
- Publication number
- CN100473401C CN100473401C CNB2006100114864A CN200610011486A CN100473401C CN 100473401 C CN100473401 C CN 100473401C CN B2006100114864 A CNB2006100114864 A CN B2006100114864A CN 200610011486 A CN200610011486 A CN 200610011486A CN 100473401 C CN100473401 C CN 100473401C
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- preventing
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 201000001429 Intracranial Thrombosis Diseases 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 206010008132 Cerebral thrombosis Diseases 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 241000255789 Bombyx mori Species 0.000 claims abstract 4
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract 2
- 241000522620 Scorpio Species 0.000 claims description 16
- 239000009490 scorpio Substances 0.000 claims description 16
- 241001038563 Pseudostellaria Species 0.000 claims description 9
- 240000000031 Achyranthes bidentata Species 0.000 claims 3
- 241001061264 Astragalus Species 0.000 claims 3
- 244000020518 Carthamus tinctorius Species 0.000 claims 3
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims 3
- 241000258920 Chilopoda Species 0.000 claims 3
- 240000002045 Guettarda speciosa Species 0.000 claims 3
- 235000001287 Guettarda speciosa Nutrition 0.000 claims 3
- 241000208966 Polygala Species 0.000 claims 3
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 3
- 241000270666 Testudines Species 0.000 claims 3
- 235000006533 astragalus Nutrition 0.000 claims 3
- 210000004233 talus Anatomy 0.000 claims 3
- 241000237502 Ostreidae Species 0.000 claims 2
- 240000005809 Prunus persica Species 0.000 claims 2
- 235000020636 oyster Nutrition 0.000 claims 2
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 241000239226 Scorpiones Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 24
- 230000008901 benefit Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 23
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 241000255791 Bombyx Species 0.000 description 14
- 241000131808 Scolopendra Species 0.000 description 14
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 14
- 239000000843 powder Substances 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 12
- 206010008190 Cerebrovascular accident Diseases 0.000 description 11
- 241000628997 Flos Species 0.000 description 11
- 239000009636 Huang Qi Substances 0.000 description 11
- 241000237636 Pheretima Species 0.000 description 11
- 208000006011 Stroke Diseases 0.000 description 11
- 210000000582 semen Anatomy 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 8
- 208000026106 cerebrovascular disease Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- 206010019468 Hemiplegia Diseases 0.000 description 7
- 230000001154 acute effect Effects 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 210000001015 abdomen Anatomy 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010010904 Convulsion Diseases 0.000 description 5
- 206010020772 Hypertension Diseases 0.000 description 5
- 241001523579 Ostrea Species 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 230000036461 convulsion Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 201000007227 lymph node tuberculosis Diseases 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 4
- 241000241550 Cyathula Species 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000002269 spontaneous effect Effects 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 230000008736 traumatic injury Effects 0.000 description 4
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 239000000812 cholinergic antagonist Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000006196 drop Substances 0.000 description 3
- -1 electuary Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 201000004792 malaria Diseases 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 229940023488 pill Drugs 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 206010040872 skin infection Diseases 0.000 description 3
- 230000002048 spasmolytic effect Effects 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010061245 Internal injury Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 206010043376 Tetanus Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 201000007201 aphasia Diseases 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 229940046011 buccal tablet Drugs 0.000 description 2
- 239000006189 buccal tablet Substances 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 206010008118 cerebral infarction Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 206010042772 syncope Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 206010012373 Depressed level of consciousness Diseases 0.000 description 1
- 206010012374 Depressed mood Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013887 Dysarthria Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000002091 Febrile Seizures Diseases 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001215120 Leptospirales Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010027295 Menometrorrhagia Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 208000003028 Stuttering Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000017733 acquired polycythemia vera Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003230 arteritis Diseases 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 208000030418 congenital vascular malformation Diseases 0.000 description 1
- 208000018631 connective tissue disease Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 206010016284 febrile convulsion Diseases 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 235000002378 plant sterols Nutrition 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 208000037244 polycythemia vera Diseases 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 208000018299 prostration Diseases 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 150000003376 silicon Chemical class 0.000 description 1
- 208000026473 slurred speech Diseases 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000005665 thrombophilia Diseases 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种预防和治疗脑血栓及后遗症的中药制剂，它是以黄芪、太子参、牡蛎、远志、鳖甲、当归、川牛膝、桃仁、红花、石菖蒲、蜈蚣、全蝎、白僵蚕和地龙为原料。本发明主要治疗脑血栓及后遗症，并可有效预防脑血栓，具有见效快、疗效好、无毒副作用的优点。The invention relates to a traditional Chinese medicine preparation for preventing and treating cerebral thrombosis and its sequelae. White silkworm and earthworm are raw materials. The invention mainly treats cerebral thrombosis and its sequelae, and can effectively prevent cerebral thrombosis, and has the advantages of quick effect, good curative effect, and no toxic and side effects.
Description
Technical field
The present invention relates to the Chinese medicine preparation of a kind of prevention and treatment cerebral thrombosis and sequela, is that a kind of prevention and treatment cerebral thrombosis and sequela are the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Acute cerebrovascular disease is a kind of non-traumatic cerebral local blood circulation obstacle that causes owing to various vascular reasons, one group of disease of focal nervous lesion occurs.Claim apoplexy, apoplexy again.Acute cerebrovascular disease is divided into hemorrhagic and ischemic two big classes according to the etiology and pathology difference clinically.Its sickness rate, disability rate, mortality rate, relapse rate are all very high, and existing data points out that apoplexy is first killer in various countries' cause of death first six digits major disease.1986～nineteen ninety of China is to ten thousand population cerebrovascular morbidity surveys surplus national seven big cities 600, average 215.8/10 ten thousand populations of sickness rate, apoplexy relapse rate 26%.Age and morbidity, being proportionate property of death, the death from cerebral hemorrhage rate is far above cerebral infarction.
Acute cerebrovascular disease belongs to disease categories such as Chinese medicine " apoplexy ", " sudden syncope ", " emotional syncope ", " hemiplegia ", " apoplexy ", " hemiplegia ".Nowadays alleged apoplexy is defined as: " apoplexy is on the basis of QI and blood interior-deficiency; meet the overstrain internal injury, be worried angry, have a liking for inducements such as food savoury, tobacco and wine; and then cause the internal organs imbalance of YIN and YANG; QI and blood is disorderly contrary, and the criminal's of flinging brain forms outside resistance of brain BI-syndrome involved the blood vessels or the blood oozing from the body openings or subcuta neous tissue brain feeling pulse; be primary symptom with the stuttering puckery or aphasia of unexpected confused servant, hemiplegia, facial hemiparalysis, speech, hemianesthesia clinically; and have onset anxious, change fast, as the characteristics that ailment said due to cold or exposure benefaction number becomes, good sending out in a kind of commonly encountered diseases of person in middle and old age.Be divided into hemorrhage apoplexy and ischemia apoplexy by characteristic of disease.”
Western medicine thinks that the factor of acute cerebrovascular disease is varied, and factor that blood vessel wall pathological changes factor, hemodynamics factor, blood constituent change, hemorheological factors etc. are arranged.Though the hypertension modal reason that is cerebral hemorrhage, its pathogenesis still has arguement so far, and simple hypertension is unlikely to cause angiorrhexis, but on the basis of vascular lesion due to the hypertension.The modal cause of disease of cerebral thrombosis is an atherosclerosis, and often with hypertension, rare reason has the inflammation of arterial wall, as tuberculosis, syphilis, suppurative, leptospiral infection, connective tissue disease, allergy arteritis etc., be also shown in congenital vascular malformation, polycythemia vera, blood hypercoagulability etc.
Cerebral hemorrhage, this class acute cerebrovascular disease of cerebral infarction, its sickness rate, case fatality rate, disability rate, relapse rate are still high, this means that Chinese and western medicine lacks effective measures to the treatment of acute cerebrovascular disease.Key is an active prevention, early discovery, early treatment.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The Chinese medicine preparation that the purpose of this invention is to provide a kind of prevention and treatment cerebral thrombosis and sequela.Have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
1～5 part of 1～10 portion of Concha Ostreae of 1～10 part of Radix Pseudostellariae of the Radix Astragali
0.5～3 part in 0.5～3 part of Semen Persicae of 1～5 part of Carapax Trionycis of Radix Polygalae
0.1～2 part of 0.5～3 part of Scolopendra of 0.5～3 portion of Radix Cyathulae of Radix Angelicae Sinensis
0.1～2 part of 0.5～3 portion of Scorpio of 0.5～3 part of Rhizoma Acori Graminei of Flos Carthami
0.5～3 part of 0.5～3 portion of Bombyx Batryticatus of Pheretima.
The weight proportion of each raw material of optimization formula of the present invention is:
2～3 parts of 3～7 portions of Concha Ostreaes of 3～7 parts of Radix Pseudostellariaes of the Radix Astragali
1～2 part in 1～2 part of Semen Persicae of 2～3 parts of Carapax Trionycis of Radix Polygalae
0.5～1.5 part of 1～2 part of Scolopendra of 1～2 portion of Radix Cyathulae of Radix Angelicae Sinensis
0.5～1.5 part of 1～2 portion of Scorpio of 1～2 part of Rhizoma Acori Graminei of Flos Carthami
1～2 part of 1～2 portion of Bombyx Batryticatus of Pheretima.
The weight proportion of each raw material of optimum formula of the present invention is:
2.5 parts of 5 portions of Concha Ostreaes of 5 parts of Radix Pseudostellariaes of the Radix Astragali
1.5 parts in 1.5 parts of Semen Persicaes of 2.5 parts of Carapax Trionycis of Radix Polygalae
1 part of 1.5 parts of Scolopendra of 1.5 portions of Radix Cyathulaes of Radix Angelicae Sinensis
1 part of 1.5 portions of Scorpio of 1.5 parts of Rhizoma Acori Graminei of Flos Carthami
1.5 parts of 1.5 portions of Bombyx Batryticatus of Pheretima.
Drug action mechanism among the present invention is as follows:
Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.What be used for that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency." Chinese medicine medicine for preventing pharmacology and application " the 1074th page.
Sweet, the little hardship of Radix Pseudostellariae nature and flavor, flat.GUIXIN, spleen, lung three warps.Effect with replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.It is tired etc. to treat cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus spontaneous perspiration, deficiency of both vital energy and Yin, spirit." Chinese medicine medicine for preventing pharmacology and application " the 287th page.
The Concha Ostreae nature and flavor are salty, be slightly cold.Return liver, gallbladder, kidney channel.Have tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.Can be used for the palpitation with fear insomnia, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid etc." Chinese medicine medicine for preventing pharmacology and application " the 674th page.
Radix Polygalae nature and flavor hardship, suffering, temperature.GUIXIN, kidney, lung meridian.Have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect.It is swollen etc. to treat phlegm retention, coma, cough, insomnia, palpitation with fear, forgetful, nocturnal emission, carbuncle skin ulcer." Chinese medicine medicine for preventing pharmacology and application " the 620th page.
The Carapax Trionycis nature and flavor are salty, flat.Return the liver,spleen,kidney warp.Have nourishing YIN for suppressing the hyperactive YANG, suppressing the hyperactive liver to relieve the wind syndrome, hard masses softening and resolving, bring down a fever and remove the effect of steaming.Can treat the hot hectic fever due to YIN-deficiency night sweat of consumptive disease, tired, the stirring of wind due to deficiency of YIN of spirit, chronic malaria malaria with splenomegaly, lump in the abdomen addiction piece, hepatosplenomegaly, menoxenia, amenorrhea menometrorrhagia, pediatric epilepsy scared, caries pain etc." Chinese medicine medicine for preventing pharmacology and application " the 1319th page.
The Radix Angelicae Sinensis nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc." Chinese medicine medicine for preventing pharmacology and application " the 553rd page.
Radix Cyathulae property is flat, and sweet and slightly bitter taste is nontoxic.Return liver, kidney channel.Have dispel the wind, dampness removing, the effect of stimulating the menstrual flow, invigorating blood circulation.Can treat rheumatism lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea, lump in the abdomen etc." Chinese medicine voluminous dictionary " the 228th page.
Semen Persicae nature and flavor hardship, sweet, flat.GUIXIN, liver, large intestine channel.Has blood stasis removing and clots absorbing, the effect of loosening bowel to relieve constipation.Can control amenorrhea, dysmenorrhea, WEIJIA, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood etc." Chinese medicine medicine for preventing pharmacology and application " the 986th page.
Flos Carthami nature and flavor suffering, temperature.GUIXIN, Liver Channel.Effect with promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Can treat that amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, traumatic injury etc." Chinese medicine medicine for preventing pharmacology and application " the 604th page.
Rhizoma Acori Graminei nature and flavor suffering, hardship, temperature.GUIXIN, stomach warp.Have removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, tranquillizing and allaying excitement, ward off dirty parasite killing, blood pressure lowering, spasmolytic, anti-inflammation, the effect of detoxifying, regulate the flow of vital energy, invigorating blood circulation.Can treat epilepsy, expectorant febrile convulsion, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, anemofrigid-damp arthralgia, stomachache, distension and fullness in the abdomen, enteritis, dysentery, chronic bronchitis, infantile pneumonia, sputum obturation, obnubilation, carbuncle tinea scabies, traumatic injury etc." Chinese medicine medicine for preventing pharmacology and application " the 399th page.
Scolopendra nature and flavor suffering, temperature, poisonous.Return Liver Channel.Effect with endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Can treat that infantile convulsion, tic spasm, middle air port are askew, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, skin infection, scrofula, venom etc." Chinese medicine medicine for preventing pharmacology and application " the 1238th page.
Scorpio nature and flavor suffering, flat, poisonous.Return Liver Channel.Effect with endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Can treat that infantile convulsion, tic spasm, middle air port are askew, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula etc." Chinese medicine medicine for preventing pharmacology and application " the 581st page.
Bombyx Batryticatus nature and flavor suffering is salty, flat.Return liver, lung, stomach warp.Effect with expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Can treat apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis etc." Chinese medicine voluminous dictionary " the 739th page.
The Pheretima nature and flavor are salty, cold.Go into liver, spleen, lung, urinary bladder channel.Have heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging diuretic effect.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pant, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection, hyperpyrexia, bronchial asthma, hypertension, psychosis, ulcer of the lower limb, eczema, erysipelas, burn and scald, fracture etc." Chinese medicine medicine for preventing pharmacology and application " the 522nd page
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch with the Radix Astragali, Radix Pseudostellariae; Concha Ostreae, Carapax Trionycis, Radix Angelicae Sinensis, Radix Cyathulae, Semen Persicae, Flos Carthami, Bombyx Batryticatus and Pheretima are minister; Radix Polygalae, Rhizoma Acori Graminei, Scolopendra and Scorpio make for assistant.All medicines are harmonious, altogether the effect of tool replenishing QI to invigorate the spleen, nourishing YIN for suppressing the hyperactive YANG, the Fructus Alpiniae Oxyphyllae of calming the nerves, promoting blood circulation to remove obstruction in the collateral.Prevention and treatment cerebral thrombosis and sequela determined curative effect, toxic and side effects is little, taking convenience.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preparation of the present invention, peroral dosage form preferably, as: tablet capsule agent, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes comprehensive function prevention and the treatment cerebral thrombosis and the sequela of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and mice is 35g crude drug/kg to the maximum tolerated dose of medicine of the present invention, is 135 times of clinical people's consumption, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention can treat cerebral thrombosis and sequela effectively, and the prevention of brain thrombosis also has better curative effect, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to treatment cerebral thrombosis and sequela.The criterion of traditional Chinese medical science sign is as follows: (the 104th page of " new Chinese medicine clinical research guideline " Zheng Xiao cornel chief editor Chinese Medicine science and technology publishing house in May, 2002 front page).
1, clinical recovery tcm clinical practice symptom, sign disappear or basic the disappearance; The sign integration reduces 〉=95%.
2, produce effects tcm clinical practice symptom, sign are obviously improved, and the sign integration reduces 〉=70%.
3, improvement tcm clinical practice symptom, sign all take a favorable turn, and the sign integration reduces 〉=30%.
4, invalid tcm clinical practice symptom, sign do not have obvious improvement, even increase the weight of, the sign integration reduces less than 30%.
For showing medicine of the present invention, as follows through clinical test results to treatment cerebral thrombosis and sequela therapeutic effect; Treatment cerebral thrombosis and sequela patient 60 examples, the age is 40～86 years old, male's 26 examples, women's 34 examples.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.28 examples of fully recovering account for 46.7%, and produce effects 18 examples account for 30%, and effective 10 examples account for 16.7%, and invalid 4 examples account for 6.7%, and total effective rate reaches more than 93%.After three course of therapy, symptoms such as patient's hemiplegia, facial hemiparalysis, slurred speech all have obvious change.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
2.5 parts of 5 portions of Concha Ostreaes of 5 parts of Radix Pseudostellariaes of the Radix Astragali
1.5 parts in 1.5 parts of Semen Persicaes of 2.5 parts of Carapax Trionycis of Radix Polygalae
1 part of 1.5 parts of Scolopendra of 1.5 portions of Radix Cyathulaes of Radix Angelicae Sinensis
1 part of 1.5 portions of Scorpio of 1.5 parts of Rhizoma Acori Graminei of Flos Carthami
1.5 parts of 1.5 portions of Bombyx Batryticatus of Pheretima.
Preparation method is to get Carapax Trionycis earlier, Scolopendra, Scorpio and Bombyx Batryticatus drying and crushing to 120～200 order fine powders, get the Radix Astragali again, Radix Pseudostellariae, Concha Ostreae, Radix Polygalae, Radix Angelicae Sinensis, the Radix Cyathulae Semen Persicae, Flos Carthami, Rhizoma Acori Graminei and Pheretima decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Carapax Trionycis, Scolopendra, Scorpio and Bombyx Batryticatus fine powder mixing, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
2.5 parts of 5 portions of Concha Ostreaes of 5 parts of Radix Pseudostellariaes of the Radix Astragali
1.5 parts in 1.5 parts of Semen Persicaes of 2.5 parts of Carapax Trionycis of Radix Polygalae
1 part of 1.5 parts of Scolopendra of 1.5 portions of Radix Cyathulaes of Radix Angelicae Sinensis
1 part of 1.5 portions of Scorpio of 1.5 parts of Rhizoma Acori Graminei of Flos Carthami
1.5 parts of 1.5 portions of Bombyx Batryticatus of Pheretima.
Preparation method is to get Carapax Trionycis earlier, Scolopendra, Scorpio and Bombyx Batryticatus drying and crushing to 120～200 order fine powders, get the Radix Astragali again, Radix Pseudostellariae, Concha Ostreae, Radix Polygalae, Radix Angelicae Sinensis, the Radix Cyathulae Semen Persicae, Flos Carthami, Rhizoma Acori Graminei and Pheretima decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Carapax Trionycis, Scolopendra, Scorpio and Bombyx Batryticatus fine powder mixing, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
2.5 parts of 5 portions of Concha Ostreaes of 5 parts of Radix Pseudostellariaes of the Radix Astragali
1.5 parts in 1.5 parts of Semen Persicaes of 2.5 parts of Carapax Trionycis of Radix Polygalae
1 part of 1.5 parts of Scolopendra of 1.5 portions of Radix Cyathulaes of Radix Angelicae Sinensis
1 part of 1.5 portions of Scorpio of 1.5 parts of Rhizoma Acori Graminei of Flos Carthami
1.5 parts of 1.5 portions of Bombyx Batryticatus of Pheretima.
Preparation method is to get Carapax Trionycis earlier, Scolopendra, Scorpio and Bombyx Batryticatus drying and crushing to 120～200 order fine powders, get the Radix Astragali again, Radix Pseudostellariae, Concha Ostreae, Radix Polygalae, Radix Angelicae Sinensis, the Radix Cyathulae Semen Persicae, Flos Carthami, Rhizoma Acori Graminei and Pheretima decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, again with clear paste and Carapax Trionycis, Scolopendra, Scorpio and Bombyx Batryticatus fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100114864A CN100473401C (en) | 2006-03-14 | 2006-03-14 | Chinese medicine preparation for preventing and treating cerebral thrombus and sequel thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100114864A CN100473401C (en) | 2006-03-14 | 2006-03-14 | Chinese medicine preparation for preventing and treating cerebral thrombus and sequel thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1857533A CN1857533A (en) | 2006-11-08 |
| CN100473401C true CN100473401C (en) | 2009-04-01 |
Family
ID=37296521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100114864A Expired - Fee Related CN100473401C (en) | 2006-03-14 | 2006-03-14 | Chinese medicine preparation for preventing and treating cerebral thrombus and sequel thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100473401C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450538C (en) * | 2006-11-15 | 2009-01-14 | 北京万寿通医药科技有限公司 | Chinese medicinal formulation for treating apoplexy sequelae |
| CN112870266A (en) * | 2021-03-26 | 2021-06-01 | 赵凤臣 | Traditional Chinese medicine formula for treating cerebral thrombosis |
-
2006
- 2006-03-14 CN CNB2006100114864A patent/CN100473401C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中药治疗29例脑血栓形成临床小结. 巫少青.江西中医药，第28卷第5期. 1997 * |
| 利用《内经》理论治疗脑血栓形成48例体会. 王丹虹.实用乡村医生杂志，第1期. 1996 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1857533A (en) | 2006-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100473413C (en) | Chinese medicine preparation for treating senile dementia | |
| CN103611085B (en) | Medicament for treating gouty arthritis and preparation method thereof | |
| CN103735721B (en) | A kind of Chinese medicine treating pink-eye | |
| CN1857668A (en) | Chloasma treating Chinese medicine preparation | |
| CN102106965B (en) | Composition for treating acute injury of soft tissue and application thereof | |
| CN104013868A (en) | Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and preparation method thereof | |
| CN104922639A (en) | Traditional Chinese medicine stomach-nourishing pill and preparation method thereof | |
| CN104257982A (en) | Traditional Chinese medicine preparation for treating chloasma | |
| CN111588828A (en) | Chinese medicinal preparation for treating new coronavirus and viral diseases, and its preparation method | |
| CN100473401C (en) | Chinese medicine preparation for preventing and treating cerebral thrombus and sequel thereof | |
| CN103285211B (en) | Traditional Chinese medicine particles for treating pathological obesity and preparation method | |
| CN103007063B (en) | Medicinal composition for treating facial paralysis and preparation method thereof | |
| CN103202985B (en) | Traditional Chinese medicine used for treating lumbar spondylosis, cervical spondylosis, sciatica and rheumatism and preparation method thereof | |
| CN102805834B (en) | Drug for curing gastritis and preparation method thereof | |
| CN105012669A (en) | Medicine for treating upper gastrointestinal hemorrhage and preparation method of medicine | |
| CN101028491B (en) | Chinese-medicinal preparation for treating ribbon bleb | |
| CN101028490A (en) | Chinese medicine for treating acne | |
| CN101204495B (en) | Peroral Chinese traditional medicine composition for chronic nephritis | |
| CN100571725C (en) | A kind of Chinese medicine preparation for the treatment of sciatica | |
| CN106166200A (en) | A kind of Chinese medicine composition treating burn due to hot liquid or fire | |
| CN100450529C (en) | Chinese medicinal preparation for treating apoplexy sequelae | |
| CN105521332A (en) | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof | |
| CN103550426A (en) | Traditional Chinese medicine composition for treating trifacial neuralgia and preparation method thereof | |
| CN100450538C (en) | Chinese medicinal formulation for treating apoplexy sequelae | |
| CN1951482A (en) | Chinese medicinal preparation for treating apoplexy sequelae |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING WAN SHOU TONG PHARMACEUTICAL TECHNOLOGY C Free format text: FORMER OWNER: WANG XINSUO Effective date: 20080822 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20080822 Address after: Room 230 (Park), No. 19 West Fourth Ring Road South, Beijing, Fengtai District, China: 100071 Applicant after: Beijing Wanshoutong Pharmaceutical Technology Corp. Address before: Beijing Fengtai Changxindian Hospital postal code: 100072 Applicant before: Wang Xinsuo |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090401 Termination date: 20100314 |