CN102210766A - Traditional Chinese medicine composition for treating mental anxiety - Google Patents
Traditional Chinese medicine composition for treating mental anxiety Download PDFInfo
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- CN102210766A CN102210766A CN 201010162808 CN201010162808A CN102210766A CN 102210766 A CN102210766 A CN 102210766A CN 201010162808 CN201010162808 CN 201010162808 CN 201010162808 A CN201010162808 A CN 201010162808A CN 102210766 A CN102210766 A CN 102210766A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating mental anxiety. Generalized anxiety is a clinical common type, characterized by chronic anxiety and easy to recur and difficult to cure. Anxiety disorder has the main symptoms of fear and tension lacking definite objects and concrete contents, and is accompanied with vegetative nerve symptoms, muscular tension and motion disturbance of patients. On treatment, medicaments with anti-anxiety effects, such as benzodiazepines, tricyclic compounds, SSRIS (selective serotonin reuptake inhibitors) and the like are adopted generally, but the side reactions are relatively large. Anxiety disorder can be classified according to the aetiological agents into types of stagnation of the liver-qi, deficiency of both heart and spleen, deficiency of heart blood, moist heat in both liver and gall and deficiency of both qi and blood by differentiation of symptoms and signs in traditional Chinese medicine. The traditional Chinese medicine composition for treating mental anxiety is capable of soothing the liver and relieving depression, arresting convulsion and soothing nerves, and is used for treating mental depression, panic insomnia, chest distress and other symptoms. The traditional Chinese medicine composition is prepared from bupleurum, angelica, chuanxiong rhizome, tuckahoe, uncaria, multiflower knoweed stem, fried bighead atractylodes rhizome and licorice. In the prescription, the bupleurum is bitter in taste and cool in nature, has good efficacies on treating alternate attacks of chills and fever, fullness sensation in chest, hypochondriac pain, bitter taste, deafness, headache, dizziness and the like. The traditional Chinese medicine composition can alleviate patients from the suffering of mental anxiety and reduce the economic burden on patients. The traditional Chinese medicine composition is a pure traditional Chinese medicine oral preparation, and can be safely taken for a long term.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of anxiety disease
(2) technical background
Anxiety disorder is modal a kind of in the mental disease among the social crowd, and generalized anxiety disorder is clinical common type, and it is a feature with chronic anxiety, and recurrence easily is difficult to cure.Having had a strong impact on patient's quality of life and cultural life, is cardinal symptom to lack the on tenterhooks and nervous of clear and definite object and particular content, and with patient's vegetative nerve symptom, muscular tone and motion are uneasy, and patient and family members all agonize for this reason.In the treatment, adopt the medicine of angst resistance effects such as Benzodiazepines tricyclic antidepressants and SSRIS class, but its side reaction is relatively large more
[1]Can be divided into liver qi stagnation type, type of deficiency of both the heart and spleen, type of insufficiency of heart-blood, liver gallbladder damp-heat type, QIXUELIANGXU type according to pathogenic factor by Chinese medical discrimination
[2]The present invention's energy soothing liver-QI for relieving depression, arresting convulsion is calmed the nerves.Be used for spirit depressing, terrified insomnia, discomfort uncomfortable in chest, anorexia Mental fatigue, and the treatment of neurosis, climacteric syndrome, the nocturnal fretfulness in infants, symptom such as grind one's teeth in sleep.
The present invention is processed into by eight flavor Chinese crude drugs such as Radix Bupleuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori, Rhizoma Atractylodis Macrocephalae (parched), Radix Glycyrrhizae.Radix Bupleuri bitter in the mouth, cool in nature in the side, have evacuate bring down a fever, effect that dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating are lifted gas, be used for the treatment of alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness etc.Modern study shows: saikoside and Radix Bupleuri volatile oil all have anticonvulsant action, behind saikoside 150mg/kg and the volatile oil 300mg/kg reasonable compatibility very strong anticonvulsant action is arranged, saikoside can also prolong the length of one's sleep of cat, so Radix Bupleuri is treated neural psychiatric department disease curative effect is preferably arranged, as paranoid fears, psychotic disorders etc. also have this department of neurology common disease of epilepsy
[3]Radix Angelicae Sinensis is warm in nature, the sweet in the mouth suffering, and GUIXIN, spleen three warps are clinical conventional Chinese medicines.The energy tonifying five ZANG-organs, granulation promoting meat is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Compendium of Material Medica: " Radix Angelicae Sinensis is controlled headache, all pains of trusted subordinate, the intestine moistening stomach, muscles and bones, skin is controlled carbuncle, evacuation of pus pain relieving and blood are enriched blood ", because of it can make each as a result institute of blood, so a Radix Angelicae Sinensis
[4]Rhizoma Chuanxiong is a samphire, and warm in nature, acrid in the mouth has the effect of blood-activating and qi-promoting, wind-expelling pain-stopping.But this medicine blood-activating and qi-promoting is opened the stasis of blood in walking to show to dispel the wind, the descending sea of blood of the up head, and the property of medicine is celebrated with versatility
[5]Poria sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen is arranged, the effect of spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, the treatment of palpitation with fear insomnia.The Ramulus Uncariae Cum Uncis sweet in the mouth, cool in nature, return the liver heart two warps, have the heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., the effect of calm rash.Compendium of Material Medica: " the big number of people revolves dizzy, and suppressing liver-wind removes heat in the heart "." interior warp ": " all wind trembling and dizziness all belong to liver ", " all sudden and violent tetanic wind that all belongs to ".Compendium of Material Medica: " Ramulus Uncariae Cum Uncis, hands, foot are fainted cloudy medicine also.The foot cloudy main air of fainting, the hands cloudy main fire of fainting, infantile convulsion is dizzy, liver-wind diseases of fire mutually all, the logical pericardium of Ramulus Uncariae Cum Uncis is in edema with the liver involved, the quiet fire of wind puts out, then all diseases from except that "
[6]The Caulis Polygoni Multiflori sweet in the mouth, property is flat.GUIXIN, Liver Channel.Nourishing blood to tranquillize the mind is arranged, the effect of dispelling wind and removing obstruction in the collateral.Be used for insomnia and dreamful sleep, blood deficiency general pain, the treatment of rheumatic arthralgia.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI is arranged, dampness diuretic, hidroschesis, effect such as antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the treatment of frequent fetal movement.In the prescription of the traditional Chinese medical science, all can be to most diseases with this Chinese medicine simply of Radix Glycyrrhizae, because Radix Glycyrrhizae has the greatest ability of coordinating the actions of various ingredients in a prescription." book on Chinese herbal medicine is just ": " Radix Glycyrrhizae, flavor are to sweet, and the property of slow neutralization has the merit of transferring benefits, thus poison get separate its poison, firm medicine gets its property of sum, what medicine administered to bring out the cold got helps outside it, put in poison delay its speed.Go into gas with the gas medicine, go into blood with the blood medicine, do not have toward can not, so title state is old ".
The survey data that World Health Organization (WHO) on February 28th, 2004 announces shows, has 27% population to suffer from various degree insomnia in the world wide approximately
[8]The present invention adds Caulis Polygoni Multiflori by the diffusing former side of bright Xue Kai " protecting baby's brief points " volume one side's subduing the hyperfunction of the liver and forms simply, Radix Bupleuri is transferred liver and clearing heat in the side, Radix Angelicae Sinensis, Rhizoma Chuanxiong nourish blood and blood, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori tranquillizing the mind by relieving convulsion are aided with the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae spleen invigorating, hold up spleen Zhi Qiben with soothing liver-QI for relieving depression, arresting convulsion is calmed the nerves and is controlled its mark, treating both the principal and secondary aspects of a disease, be elder generation, evident in efficacy.
(3) summary of the invention
The present invention is processed into by eight flavor Chinese crude drugs such as Radix Bupleuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori, Rhizoma Atractylodis Macrocephalae (parched), Radix Glycyrrhizae.Radix Bupleuri bitter in the mouth, cool in nature in the side, have evacuate bring down a fever, effect that dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating are lifted gas, be used for the treatment of alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness etc.Modern study shows: saikoside and Radix Bupleuri volatile oil all have anticonvulsant action, behind saikoside 150mg/kg and the volatile oil 300mg/kg reasonable compatibility very strong anticonvulsant action is arranged, saikoside can also prolong the length of one's sleep of cat, so Radix Bupleuri is treated neural psychiatric department disease curative effect is preferably arranged, as paranoid fears, psychotic disorders etc. also have this department of neurology common disease of epilepsy
[3]Radix Angelicae Sinensis is warm in nature, the sweet in the mouth suffering, and GUIXIN, spleen three warps are clinical conventional Chinese medicines.The energy tonifying five ZANG-organs, granulation promoting meat is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Compendium of Material Medica: " Radix Angelicae Sinensis is controlled headache, all pains of trusted subordinate, the intestine moistening stomach, muscles and bones, skin is controlled carbuncle, evacuation of pus pain relieving and blood are enriched blood ", because of it can make each as a result institute of blood, so a Radix Angelicae Sinensis
[4]Rhizoma Chuanxiong is a samphire, and warm in nature, acrid in the mouth has the effect of blood-activating and qi-promoting, wind-expelling pain-stopping.But this medicine blood-activating and qi-promoting is opened the stasis of blood in walking to show to dispel the wind, the descending sea of blood of the up head, and the property of medicine is celebrated with versatility
[5]Poria sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen is arranged, the effect of spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, the treatment of palpitation with fear insomnia.The Ramulus Uncariae Cum Uncis sweet in the mouth, cool in nature, return the liver heart two warps, have the heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., the effect of calm rash.Compendium of Material Medica: " the big number of people revolves dizzy, and suppressing liver-wind removes heat in the heart "." interior warp ": " all wind trembling and dizziness all belong to liver ", " all sudden and violent tetanic wind that all belongs to ".Compendium of Material Medica: " Ramulus Uncariae Cum Uncis, hands, foot are fainted cloudy medicine also.The foot cloudy main air of fainting, the hands cloudy main fire of fainting, infantile convulsion is dizzy, liver-wind diseases of fire mutually all, the logical pericardium of Ramulus Uncariae Cum Uncis is in edema with the liver involved, the quiet fire of wind puts out, then all diseases from except that "
[6]The Caulis Polygoni Multiflori sweet in the mouth, property is flat.GUIXIN, Liver Channel.Nourishing blood to tranquillize the mind is arranged, the effect of dispelling wind and removing obstruction in the collateral.Be used for insomnia and dreamful sleep, blood deficiency general pain, the treatment of rheumatic arthralgia.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI is arranged, dampness diuretic, hidroschesis, effect such as antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the treatment of frequent fetal movement.In the prescription of the traditional Chinese medical science, all can be to most diseases with this Chinese medicine simply of Radix Glycyrrhizae, because Radix Glycyrrhizae has the greatest ability of coordinating the actions of various ingredients in a prescription." book on Chinese herbal medicine is just ": " Radix Glycyrrhizae, flavor are to sweet, and the property of slow neutralization has the merit of transferring benefits, thus poison get separate its poison, firm medicine gets its property of sum, what medicine administered to bring out the cold got helps outside it, put in poison delay its speed.Go into gas with the gas medicine, go into blood with the blood medicine, do not have toward can not, so title state is old ".
The technical scheme that adopts:
A kind of Chinese medicine composition for the treatment of anxiety.Wherein Main Ingredients and Appearance is compositions such as Radix Bupleuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae.Described a kind of Chinese medicine composition for the treatment of anxiety, its character can be powder or graininess, dosage form can be hard capsule, soft capsule, tablet, granule, pill or oral solutions etc.
A kind of production method for the treatment of the Chinese medicine composition of anxiety of the present invention is a kind of known technology, and the extract that had both used conventional extracting method to make can be prepared as capsule, soft capsule, tablet, granule, oral liquid or pill.Its excipient is different in different dosage forms, for example may add other pharmaceutic adjuvants such as starch during capsule and be in preparation diluent, gelatinized corn starch or ethanol or other for the adhesive granulation encapsulated; When being pressed into tablet, may add an amount of starch or Starch Sodium and make adhesive as diluent, gelatinized corn starch and other adjuvant.Owing to be to adopt conventional preparation production technology to produce medicine of the present invention,, its production method do not elaborate so not doing.
Characteristics of the present invention:
1, anxiety disorder is modal a kind of in the mental disease among the social crowd, and generalized anxiety disorder is clinical common type, and it is a feature with chronic anxiety, and recurrence easily is difficult to cure.Having had a strong impact on patient's quality of life and cultural life, is cardinal symptom to lack the on tenterhooks and nervous of clear and definite object and particular content, and with patient's vegetative nerve symptom, muscular tone and motion are uneasy, and patient and family members all agonize for this reason.In the treatment, adopt the medicine of angst resistance effects such as Benzodiazepines tricyclic antidepressants and SSRIS class, but its side reaction is relatively large more
[1]Can be divided into liver qi stagnation type, type of deficiency of both the heart and spleen, type of insufficiency of heart-blood, liver gallbladder damp-heat type, QIXUELIANGXU type according to pathogenic factor by Chinese medical discrimination
[2]The present invention's energy soothing liver-QI for relieving depression, arresting convulsion is calmed the nerves.Be used for spirit depressing, terrified insomnia, discomfort uncomfortable in chest, anorexia Mental fatigue, and the treatment of neurosis, climacteric syndrome, the nocturnal fretfulness in infants, symptom such as grind one's teeth in sleep.
The present invention is processed into by eight flavor Chinese crude drugs such as Radix Bupleuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori, Rhizoma Atractylodis Macrocephalae (parched), Radix Glycyrrhizae.Radix Bupleuri bitter in the mouth, cool in nature in the side, have evacuate bring down a fever, effect that dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating are lifted gas, be used for the treatment of alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness etc.
2, the present invention's misery that can alleviate patient's anxiety can alleviate patient's medical economics burden again.
3, this medicine is pure oral preparation of Chinese traditional medicinal, through clinical safe in utilization for many years effective, can take for a long time, also is fit to the characteristics that these disease needs are taken medicine for a long time.
(4) the specific embodiment of the present invention: (by the weight fraction ratio of various compositions)
Embodiment 1:
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry, make tablet.
Embodiment 2
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry,, make capsule.
Embodiment example 3
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry, make pill.
Embodiment 4:
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, mix, make soft capsule.
Embodiment 5:
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry, make granule.
Embodiment 6:
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, mix, make oral solutions.
Claims (1)
1. concrete right of the present invention requires: (by the weight fraction ratio of various compositions)
Embodiment 1:
1 gets 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry, make tablet.
2 embodiment 2
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry,, make capsule.
Embodiment example 3
3 get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry, make pill.
Embodiment 4:
4 get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, mix, and make soft capsule.
Embodiment 5:
5 get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, granulate, dry, make granule.
6 embodiment 6:
Get 1~10 part of Radix Bupleuri, 1~10 part of Radix Angelicae Sinensis, 1~10 part of Rhizoma Chuanxiong, 1~10 part in Poria, 1~10 part of Ramulus Uncariae Cum Uncis, 1~10 part of extraction of Caulis Polygoni Multiflori, 1~10 part of the Rhizoma Atractylodis Macrocephalae, 1~10 part of mixing of Radix Glycyrrhizae, mix, make oral solutions.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103041351A (en) * | 2012-12-31 | 2013-04-17 | 王彬 | Decoction for treating dysthymia |
CN104041871A (en) * | 2014-06-16 | 2014-09-17 | 哈尔滨升益生物科技开发有限公司 | Gambir plant soup with functions of calming nerves and arresting palpitation and production method thereof |
CN105168456A (en) * | 2015-09-16 | 2015-12-23 | 韩志强 | Anle tablet |
CN113144106A (en) * | 2021-04-22 | 2021-07-23 | 寇绍杰 | Anxiolytic drug |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1739648A (en) * | 2005-09-06 | 2006-03-01 | 王衡新 | Antidepressant Chinese medicine prepn and its prepn process and quality control method |
-
2010
- 2010-04-05 CN CN 201010162808 patent/CN102210766A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1739648A (en) * | 2005-09-06 | 2006-03-01 | 王衡新 | Antidepressant Chinese medicine prepn and its prepn process and quality control method |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103041351A (en) * | 2012-12-31 | 2013-04-17 | 王彬 | Decoction for treating dysthymia |
CN104041871A (en) * | 2014-06-16 | 2014-09-17 | 哈尔滨升益生物科技开发有限公司 | Gambir plant soup with functions of calming nerves and arresting palpitation and production method thereof |
CN105168456A (en) * | 2015-09-16 | 2015-12-23 | 韩志强 | Anle tablet |
CN113144106A (en) * | 2021-04-22 | 2021-07-23 | 寇绍杰 | Anxiolytic drug |
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Application publication date: 20111012 |