CN100473413C - Chinese medicine preparation for treating senile dementia - Google Patents

Chinese medicine preparation for treating senile dementia Download PDF

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Publication number
CN100473413C
CN100473413C CNB2006100114845A CN200610011484A CN100473413C CN 100473413 C CN100473413 C CN 100473413C CN B2006100114845 A CNB2006100114845 A CN B2006100114845A CN 200610011484 A CN200610011484 A CN 200610011484A CN 100473413 C CN100473413 C CN 100473413C
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parts
radix
rhizoma
chinese medicine
senile dementia
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CN1857666A (en
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王信锁
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Beijing Wanshoutong Pharmaceutical Technology Corp.
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BEIJING WANSHOUTONG PHARMACEUTICAL TECHNOLOGY CORP
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Abstract

The present invention relates to a kind of Chinese medicine preparation for treating senile dementia, and the Chinese medicine preparation is prepared with astragalus root, gastrodia tuber, tuckahoe, grass-leavedsweetflag, ginseng and other ten kinds of Chinese medicinal materials. The Chinese medicine preparation is used mainly for treating and preventing senile dementia, and has the advantages of fast acting, high curative effect and no toxic side effect.

Description

A kind of Chinese medicine preparation for the treatment of senile dementia
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of senile dementia, is that a kind of senile dementia for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Senile dementia claims senile dementia again, is one group of common chronic progressive external mental deterioration disease of geratic period.Think at present, senile dementia is because one group of syndrome of the senior cerebral disorder that organic lesion chronic or carrying out property brain structure causes, it is the persistent comprehensive hypophrenia that the patient occurs under the state of Consciousness, showing as memory, computing power, judgment, attention, abstract thinking ability, language function goes down, emotion and behavior disorder are lived on one's own life and the ability to work forfeiture.According to " result of study finds that prevalence of dementia is 8.9% among city, Guangzhou 75 years old and the above old man, and men and women's prevalence is respectively 2.91% and 13.11%.75~79 years old old man's prevalence be 4.85%, 80~84 years old be 9.16%.85 years old and above be 26.14%.The alzheimer disease prevalence is 7.49%, wherein masculinity and femininity is respectively 2.01% and 11.36%, the alzheimer disease prevalence of 75~79 years old, 80~84 years old and 85 years old and above age bracket is respectively 3.28%, 7.93% and 25.13%, three age bracket old man vascular dementia prevalence and then is respectively 1.47%, 0.94% and 0.27%.75~84 years old old man's dementia and alzheimer disease prevalence are lower than Shanghai results reported 12.33~15.19% and 10.95~13.29%, but apparently higher than survey results such as Wuhan, Beijing.Dull-witted and 90 years results of study in the then a little higher than Shanghai of alzheimer disease prevalence of old man more than 85 years old.
Senile dementia belongs to categories such as Chinese medicine " slow-witted card ", " depressive psychosis ", " forgetful ", " dementia ", " melancholia ".Chinese medicine is thought the sick position of senile dementia at brain, and is closely related with the imbalance of conscience spleen renal function.Year high healthy energy is lost void and damaged by excess of seven emotions, disorder of emotion is the important cause of disease of primary disease, and main diseases is because essence, gas, anemia are decreased not enoughly, brain is lost fill, brain becomes homeless to support and reach wind, fire, expectorant, all evil internal resistances of the stasis of blood, on disturb key clearly, clear key is covered, and causes dysfunction of the mind eventually, and is dull-witted living then.Its pathology character is deficiency in origin and excess in superficiality, the clinical syndrome of intermingled deficiency and excess of seeing more.Doctor trained in Western medicine thinks that the cause of disease of alzheimer disease do not illustrate at present as yet fully.Several main hypothesis are as follows: (one) Inheritance history, (two) infect hypothesis, (three) immune hypothesis, (four) choline system defect, (five) brain injury hypothesis etc.
The traditional Chinese medical science thinks that primary disease is the card of deficiency in origin and excess in superficiality, sees with simulataneous insufficiency and excessive person clinically.Thereby dialectically distinguish deficiency and excess when being guiding principle with deficiency and excess or zang-fu disharmony, distinguish primary and secondary.Treatment of deficiency-syndrome by reinforcement in treatment, the treating excess syndrome with purgative methods.Resolving depression eliminating stagnation, tonify deficiency benefit damage are principle of treatment.The differential diagnosis in tcm treatment can be divided into: deficiency of marrow-reservoir, deficiency of both the liver and kidney, asthenia of both the spleen and kidney, hyperactivity of hesrt-fire and liver-fire, turbid phlegm blocking the clear orifices, disease types such as qi depression to blood stasis.The western medical treatment senile dementia does not still have specific treatment medicine and method at present because the cause of disease is not bright.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of senile dementia, have determined curative effect, safe ready, little, the cheap characteristics of side effect.
The present invention is made by the following weight proportion raw material:
0.5~2 part of 1.5~6 portions of Radix Curcumae of 3~12 parts of Radix Rehmanniae Preparata of the Radix Astragali
0.5~2 part of 1.5~6 parts of Radix Ginseng of 1.5~6 parts of Rhizoma Acori Graminei of Poria
1.5~6 parts in 1.5~6 parts of Rhizoma Gastrodiaes of 1.5~6 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
1.5~6 parts of 1.5~6 parts of Rhizoma Chuanxiongs of 1.5~6 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
1.5~6 parts of 1.5~6 parts of Radix Polygalaes of 1.5~6 parts of Herba Epimedii of Rhizoma Dioscoreae.
The weight proportion of each raw material of optimization formula of the present invention is:
0.8~1.2 part of 2~4 portions of Radix Curcumae of 5~7 parts of Radix Rehmanniae Preparata of the Radix Astragali
0.8~1.2 part of 2~4 parts of Radix Ginseng of 2~4 parts of Rhizoma Acori Graminei of Poria
2~4 parts in 2~4 parts of Rhizoma Gastrodiaes of 2~4 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
2~4 parts of 2~4 parts of Rhizoma Chuanxiongs of 2~4 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
2~4 parts of 2~4 parts of Radix Polygalaes of 2~4 parts of Herba Epimedii of Rhizoma Dioscoreae.
The weight proportion of each raw material of optimum formula of the present invention is:
1 part of 3 portions of Radix Curcumae of 6 parts of Radix Rehmanniae Preparata of the Radix Astragali
1 part of 3 parts of Radix Ginseng of 3 parts of Rhizoma Acori Graminei of Poria
3 parts in 3 parts of Rhizoma Gastrodiaes of 3 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
3 parts of 3 parts of Radix Polygalaes of 3 parts of Herba Epimedii of Rhizoma Dioscoreae.
Drug action mechanism among the present invention is as follows:
Radix Astragali nature and flavor are sweet, warm.Return lung, spleen channel.Have benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, the effect of granulation promoting.What be used for that internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle do not burst or burst does not hold back and the disease of all weakness of QI blood deficiency." Chinese medicine medicine for preventing pharmacology and application " the 1074th page.
The Rhizoma Gastrodiae nature and flavor are sweet, flat.Return Liver Channel.Effect with endogenous wind stopping, arresting convulsion.Can treat dizzy pupil, wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom etc." Chinese medicine voluminous dictionary " the 316th page.
Radix Curcumae nature and flavor suffering, hardship, cold.GUIXIN, lung, Liver Channel.Effect with promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs, promoting the function of the gallbladder to alleviate jaundice, the relieving restlessness that clears away heart-fire.Can treat all pains of breast abdomen side of body rib, frustrated demented, calentura coma, haematemesis, epistaxis, hematuria, women's vicarious menstruation, jaundice, arteriosclerosis etc." Chinese medicine medicine for preventing pharmacology and application " the 794th page.
The Poria nature and flavor are sweet, flat, light.GUIXIN, lung, spleen, kidney channel.Effect with eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Can treat that dysuria, edema distension, phlegm retention cough with dyspnea, brain are throbbed with fear, have loose bowels in the loose stool, irritability, palpitation with fear, insomnia, forgetful, seminal emission, stranguria with turbid discharge, insufficiency of the spleen, stop that drink is not eaten, gastral cavity is vexed, three YIN malaria (malaria pathogen in three YIN) disease, heating do not heal, end empty YANG-depletion etc." Chinese medicine medicine for preventing pharmacology and application " the 898th page.
Rhizoma Acori Graminei nature and flavor suffering, hardship, temperature.GUIXIN, stomach warp.Have removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, tranquillizing and allaying excitement, ward off dirty parasite killing, blood pressure lowering, spasmolytic, anti-inflammation, the effect of detoxifying, regulate the flow of vital energy, invigorating blood circulation.Can treat epilepsy, expectorant febrile convulsion, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, anemofrigid-damp arthralgia, stomachache, distension and fullness in the abdomen, enteritis, dysentery, chronic bronchitis, infantile pneumonia, sputum obturation, obnubilation, carbuncle tinea scabies, traumatic injury etc." Chinese medicine medicine for preventing pharmacology and application " the 399th page.
Sweet, the little hardship of Radix Ginseng nature and flavor, flat.Return spleen, lung, the heart, stomach warp.The effect of have strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promote the production of body fluid, calming the nerves.Can treat that weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, regurgitation tell that food, stool lingering diarrhea, Tianjin wound are thirsty, the disease of prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb, frequent micturition, woman uterine bleeding, children's's intermittent infantile convulsion, mental energy weakness, cardiogenic shock, neurasthenia, all qi-blood-body fluid deficiencies." Chinese medicine medicine for preventing pharmacology and application " the 26th page.
The Fructus Lycii nature and flavor are sweet, flat.Return liver, kidney channel.Effect with nourishing the liver and kidney, replenishing vital essence to improve eyesight.Can treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tears of blurred vision, cough due to consumptive disease, quench one's thirst, seminal emission, blood deficiency and yellow complexion, neurasthenia, hepatitis, furuncle and phyma, chilblain, scald, decubital ulcer, chronic atrophic gastritis, stomach, duodenal bulbar ulcer etc." Chinese medicine medicine for preventing pharmacology and application " the 869th page.
Fructus Alpiniae Oxyphyllae nature and flavor suffering, temperature.Return spleen, kidney channel.Has effect warming spleen and stopping diarrha, warming the kidney controlling nocturnal emission with astringent drugs reducing urination.Can treat that spleen-cold syndrome is had loose bowels, cold type of pain in the abdomen, mouthful slaver over more, enuresis due to deficiency of the kidney, frequent micturition, seminal emission blood are turbid etc." Chinese medicine medicine for preventing pharmacology and application " the 1048th page.
Sweet, the tepor of Radix Rehmanniae Preparata nature and flavor.Return liver, kidney channel.Has the effect that nourishing YIN and supplementing blood, beneficial essence are filled out marrow.Can treat that the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair etc." Chinese medicine medicine for preventing pharmacology and application " the 514th page.
Rhizoma Anemarrhenae nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing.Can treat that fever caused by exogenous pathogenic factors, hyperpyrexia excessive thirst, tuberculosis heating, cough due to lung-heat, osteopyrexia and fever, interior-heat are quenched one's thirst, the dryness of the intestine constipation, dysuria, diabetes etc." Chinese medicine medicine for preventing pharmacology and application " the 817th page.
Radix Cyathulae property is flat, and sweet and slightly bitter taste is nontoxic.Return liver, kidney channel.Have dispel the wind, dampness removing, the effect of stimulating the menstrual flow, invigorating blood circulation.Can treat rheumatism lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea, lump in the abdomen etc." Chinese medicine voluminous dictionary " the 228th page.
Rhizoma Chuanxiong nature and flavor suffering, perfume (or spice).Return liver, gallbladder, pericardium channel.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Can treat menoxenia, amenorrhea dysmenorrhea, difficult labour, stasis of blood resistance pain, lump in the abdomen stomachache, the twinge of the breast side of body, arthralgia due to cold clonic spasm of the muscle, tumbling and swelling, headache due to pathogenic wind-heat, rheumatic arthralgia, skin infection swells and ache, placenta retention, cerebral ischemia, coronary heart disease, angina pectoris, atherosclerosis, hypertension, radiotherapy, leukopenia due to the chemotherapy, juvenile myopia, vitamin e deficiency, flu is dizzy, external plug nose treating malaria disease etc." Chinese medicine medicine for preventing pharmacology and application " the 171st page.
The Rhizoma Dioscoreae nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Have the spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Can treat that the deficiency of vital energy is weak, diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to deficiency of the lung, quench one's thirst, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, diabetes, the enuresis, chronic nephritis, chronic enteritis etc." Chinese medicine medicine for preventing pharmacology and application " the 137th page.
Herba Epimedii nature and flavor suffering, sweet, warm.Return liver, kidney channel.Effect with kidney invigorating and YANG supporting, expelling wind and removing dampness, bone and muscle strengthening.Can treat that sexual impotence erectile problem, dribbling urination, muscles and bones contraction urgency, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless, climacteric hypertension disease, Mental fatigue are forgetful, neurasthenia, osteomyelitis etc." Chinese medicine medicine for preventing pharmacology and application " the 1143rd page.
Radix Polygalae nature and flavor hardship, suffering, temperature.GUIXIN, kidney, lung meridian.Have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the repercussive effect.It is swollen etc. to treat phlegm retention, coma, cough, insomnia, palpitation with fear, forgetful, nocturnal emission, carbuncle skin ulcer." Chinese medicine medicine for preventing pharmacology and application " the 620th page.
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with the Radix Astragali, Rhizoma Gastrodiae, Radix Ginseng and Fructus Alpiniae Oxyphyllae, and Poria, Fructus Lycii, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Radix Cyathulae, Rhizoma Dioscoreae and Herba Epimedii are ministerial drug, and Radix Polygalae, Rhizoma Acori Graminei, Radix Curcumae and Rhizoma Chuanxiong are adjuvant.All medicines amount to the effect of tool replenishing QI to invigorate the spleen, nourishing YIN and supplementing blood, the eliminating phlegm of having one's ideas straightened out, the Fructus Alpiniae Oxyphyllae of calming the nerves mutually.Treatment and prevention senile dementia, determined curative effect, toxic and side effects is little, and taking convenience is cheap.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: tablet, capsule, oral agents, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention senile dementia of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and mice is 50g crude drug/kg to the maximum tolerated dose of medicine of the present invention, is 170 times of clinical people's consumption, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention can effectively treat senile dementia, and the prevention senile dementia also has better curative effect, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment senile dementia.Senile dementia curative effect determinate standard (the 98th page of " new Chinese medicine clinical research guideline " Zheng Xiao cornel chief editor Chinese Medicine science and technology publishing house in May, 2002 front page).
1, the symptom of clinical recovery kidney yin deficient syndrome, sign disappear or basic the disappearance; The sign integration reduces 〉=95%.
2, produce effects symptom, sign are obviously improved, and the sign integration reduces 〉=70%.
3, improvement symptom, sign all take a favorable turn, and the sign integration reduces 〉=30%.
4, invalid symptom, sign do not have obvious improvement, even increase the weight of, the sign integration reduces less than 30%.
As follows through clinical test results; Treatment senile dementia patient 50 examples, male's 22 examples, women's 28 examples, the age is 70~90 years old, takes embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.18 examples of fully recovering account for 36%, and produce effects 22 examples account for 44%, and effective 6 examples account for 12%, and invalid 4 examples account for 8%, and total effective rate reaches 92%.After three course of therapy, patient's dysmnesia, abstract thinking obstacle and other neurological symptoms etc. all have obvious change.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
1 part of 3 portions of Radix Curcumae of 6 parts of Radix Rehmanniae Preparata of the Radix Astragali
1 part of 3 parts of Radix Ginseng of 3 parts of Rhizoma Acori Graminei of Poria
3 parts in 3 parts of Rhizoma Gastrodiaes of 3 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
3 parts of 3 parts of Radix Polygalaes of 3 parts of Herba Epimedii of Rhizoma Dioscoreae.
Preparation method is to get Radix Ginseng and Rhizoma Gastrodiae drying and crushing to 120~200 order fine powders earlier, get the Radix Astragali again, Poria, Rhizoma Acori Graminei, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Radix Cyathulae, Rhizoma Chuanxiong, Rhizoma Dioscoreae, Herba Epimedii, Radix Polygalae and Radix Curcumae decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and Radix Ginseng and Rhizoma Gastrodiae fine powder mixing, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
1 part of 3 portions of Radix Curcumae of 6 parts of Radix Rehmanniae Preparata of the Radix Astragali
1 part of 3 parts of Radix Ginseng of 3 parts of Rhizoma Acori Graminei of Poria
3 parts in 3 parts of Rhizoma Gastrodiaes of 3 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
3 parts of 3 parts of Radix Polygalaes of 3 parts of Herba Epimedii of Rhizoma Dioscoreae.
Preparation method is to get Radix Ginseng and Rhizoma Gastrodiae drying and crushing to 120~200 order fine powders earlier, get the Radix Astragali again, Poria, Rhizoma Acori Graminei, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Radix Cyathulae, Rhizoma Chuanxiong, Rhizoma Dioscoreae, Herba Epimedii, Radix Polygalae and Radix Curcumae decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, and reclaimed ethanol, when 50 degree~55 are spent, be concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and Radix Ginseng and Rhizoma Gastrodiae fine powder mixing, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2~10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
1 part of 3 portions of Radix Curcumae of 6 parts of Radix Rehmanniae Preparata of the Radix Astragali
1 part of 3 parts of Radix Ginseng of 3 parts of Rhizoma Acori Graminei of Poria
3 parts in 3 parts of Rhizoma Gastrodiaes of 3 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
3 parts of 3 parts of Radix Polygalaes of 3 parts of Herba Epimedii of Rhizoma Dioscoreae.
Preparation method is to get Radix Ginseng and Rhizoma Gastrodiae drying and crushing to 120~200 order fine powders earlier, get the Radix Astragali again, Poria, Rhizoma Acori Graminei, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Radix Cyathulae, Rhizoma Chuanxiong, Rhizoma Dioscoreae, Herba Epimedii, Radix Polygalae and Radix Curcumae decoct with water twice, 1.5~2 hours for the first time, 0.5~1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree~85 when spending, the clear paste of relative density 1.08~1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree~55 are concentrated into the clear paste of relative density 1.30~1.32, again with clear paste and Radix Ginseng and Rhizoma Gastrodiae fine powder mixing, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1~3 bag, three to four times on the one, one month is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of senile dementia is characterized in that it is made by following raw materials by weight proportions:
0.5~2 part of 1.5~6 portions of Radix Curcumae of 3~12 parts of Radix Rehmanniae Preparata of the Radix Astragali
0.5~2 part of 1.5~6 parts of Radix Ginseng of 1.5~6 parts of Rhizoma Acori Graminei of Poria
1.5~6 parts in 1.5~6 parts of Rhizoma Gastrodiaes of 1.5~6 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
1.5~6 parts of 1.5~6 parts of Rhizoma Chuanxiongs of 1.5~6 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
1.5~6 parts of 1.5~6 parts of Radix Polygalaes of 1.5~6 parts of Herba Epimedii of Rhizoma Dioscoreae.
2, a kind of Chinese medicine preparation for the treatment of senile dementia according to claim 1, wherein the weight proportion of each crude drug is:
0.8~1.2 part of 2~4 portions of Radix Curcumae of 5~7 parts of Radix Rehmanniae Preparata of the Radix Astragali
0.8~1.2 part of 2~4 parts of Radix Ginseng of 2~4 parts of Rhizoma Acori Graminei of Poria
2~4 parts in 2~4 parts of Rhizoma Gastrodiaes of 2~4 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
2~4 parts of 2~4 parts of Rhizoma Chuanxiongs of 2~4 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
2~4 parts of 2~4 parts of Radix Polygalaes of 2~4 parts of Herba Epimedii of Rhizoma Dioscoreae.
3, a kind of Chinese medicine preparation for the treatment of senile dementia according to claim 1, wherein the weight proportion of each crude drug is:
1 part of 3 portions of Radix Curcumae of 6 parts of Radix Rehmanniae Preparata of the Radix Astragali
1 part of 3 parts of Radix Ginseng of 3 parts of Rhizoma Acori Graminei of Poria
3 parts in 3 parts of Rhizoma Gastrodiaes of 3 parts of Fructus Alpiniae Oxyphyllae of Fructus Lycii
3 parts of 3 parts of Rhizoma Chuanxiongs of 3 portions of Radix Cyathulaes of the Rhizoma Anemarrhenae
3 parts of 3 parts of Radix Polygalaes of 3 parts of Herba Epimedii of Rhizoma Dioscoreae.
CNB2006100114845A 2006-03-14 2006-03-14 Chinese medicine preparation for treating senile dementia Expired - Fee Related CN100473413C (en)

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