CN101549105A - Traditional Chinese medicine composition for treating migraine - Google Patents
Traditional Chinese medicine composition for treating migraine Download PDFInfo
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- CN101549105A CN101549105A CNA2008101034137A CN200810103413A CN101549105A CN 101549105 A CN101549105 A CN 101549105A CN A2008101034137 A CNA2008101034137 A CN A2008101034137A CN 200810103413 A CN200810103413 A CN 200810103413A CN 101549105 A CN101549105 A CN 101549105A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating migraine, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is of powder, granules, capsules, tablets and the like prepared by 12 Chinese medicinal materials of Szechuan lovage rhizome, Chinese thorowax root, pinellia tuber, tall gastrodia tuber, dahurian angelica root, honeysuckle flower, baical skullcap root, manchurian wildginger, liquoric root, Chinese angelica, chrysanthemum and peach seed with a certain proportion according to a specific process. The traditional Chinese medicine composition has reasonable formula and advanced process, can promote blood circulation, dredge channels, dispel pathogenic wind and relieve pain, is characterized by significant efficacies, good analgesic effect, convenient carry, no side effects and the like and is applicable to patients with various types of headache, thereby being a preferred prepration for treating the migraine.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of Chinese medicine composition, be specifically related to a kind ofly be used for the treatment of migrainous Chinese medicine composition, and its preparation method has been done correlational study.
Technical background
Migraine is the most common and most important vascular headache that is, presents throbbing pain consistent with pulse or distending pain.Bow, be heated, exert oneself, cough etc. all can make headache increase the weight of.Check visible temporo tremulous pulse protuberance, the enhancing of beating, compressing back headache can alleviate.The adolescence of being everlasting morbidity, part patient has family history, how because of bringing out in fatigue, emotional factor, menstrual period etc.
Its headache symptom shows as: behind the tendency transference cure, severe headache occurs, is positioned at a side, be pulsatory feeling, burn feeling, and climing gradually and full head, the companion feels sick, vomiting, photophobia, phonophobia, continue 4～72 hours.Patient is willing to be intended to have a rest in the black room, and the most patient of if can sleeping can be alleviated.
As a kind of commonly encountered diseases, before 3000, just there is the people that migraine is described.Used till today by called after migraine at the bottom of the uncommon ripple carat of the doctor of ancient Greek before 2500 always.Migraine belongs to motherland's medical science " migraine ".The traditional Chinese medical science is thought, all YANG-meridians meeting into the head is again the brain place.Heresy of ancient six climate exopathogens is outer attacks or the internal organs imbalance of YIN and YANG, all can cause QI and blood disorderly contrary, stasis of blood resistance meridians for a long time then brain become homeless and support and a migraine.
Modern pharmacology and clinical research show: the treatment migraine should adopt Chinese medicines such as Semen Persicae, Rhizoma Chuanxiong, Flos Carthami, Radix Angelicae Sinensis, Radix Bupleuri, Radix Rehmanniae, Radix Achyranthis Bidentatae.These Chinese medicines have the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, especially have kind control shaoyin channel, the headache of fault yin channel with Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Rehmanniae, Semen Persicae, Radix Achyranthis Bidentatae, Radix Bupleuri can reduce blood viscosity, the cerebral blood flow increasing amount reduces peripheral vascular resistance, suppresses cerebral cortex and regulates vasomotoricity, play stabilizing the emotions, regulate insomnia, reach headache, the effect for the treatment of both the principal and secondary aspects of a disease removed at once.
Summary of the invention
The object of the invention is to provide a kind of migrainous Chinese medicine composition that is used for the treatment of, and comprises its formula combination and preparation method.
Be achieved through the following technical solutions order of the present invention:
1, the present invention is made by the following weight proportion raw material:
80～150 parts of 80～150 parts of Rhizoma Pinelliaes of 80～150 parts of Radix Bupleuri of Rhizoma Chuanxiong
100～200 parts of 50～100 portions of Flos Loniceraes of 80～150 parts of Radixs Angelicae Dahuricae of Rhizoma Gastrodiae
50～100 parts in 50～100 portions of Radix Glycyrrhizaes of 80～150 parts of Herba Asaris of Radix Scutellariae
50～100 parts in 100～200 parts of Semen Persicaes of 50～100 parts of Flos Chrysanthemis of Radix Angelicae Sinensis
2, best each the raw material weight proportioning of prescription of the present invention is:
110 parts of 110 parts of Rhizoma Pinelliaes of 110 parts of Radix Bupleuri of Rhizoma Chuanxiong
180 parts of 80 portions of Flos Loniceraes of 110 parts of Radixs Angelicae Dahuricae of Rhizoma Gastrodiae
80 parts in 80 portions of Radix Glycyrrhizaes of 100 parts of Herba Asaris of Radix Scutellariae
80 parts in 180 parts of Semen Persicaes of 80 parts of Flos Chrysanthemis of Radix Angelicae Sinensis
3, preparation method:
(1) get Rhizoma Chuanxiong, Radix Bupleuri, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis mixing, soak and spend the night, sealing was distilled 5～8 hours, extracted volatile oil; After getting beta-schardinger dextrin-and water and grinding well, the alcoholic solution that adds volatile oil grinds to form pastel in mortar, lyophilization, Benexate Hydrochloride, standby;
(2) get the Rhizoma Pinelliae, Rhizoma Gastrodiae, Flos Lonicerae, Flos Chrysanthemi, Semen Persicae and above-mentioned medicinal residues and mix, decoct with water each 1～2 hour 3～5 times, merge decocting liquid, filter, 70 ℃ of reclaim under reduced pressure are concentrated in right amount, the ethanol that adds equivalent, in 3～5 ℃ leave standstill 12 hours after, centrifugal, get supernatant, decompression recycling ethanol also is concentrated into extractum, takes out cold drying, be ground into fine powder, standby;
(3) get Radix Scutellariae, Herba Asari, Radix Glycyrrhizae, add 80～100% alcohol reflux 2～4 times, each 1 hour, merge extractive liquid, filters, and is evaporated to extractum, takes out, and is dried to dried cream, is ground into fine powder, and was standby;
(4) get above-mentioned Benexate Hydrochloride, two fine powder mixings, dry below 50 ℃, and/or the suitable pharmaceutics adjuvant of adding, comprise: starch, dextrin, sucrose, lactose, calcium hydrogen phosphate, sodium carboxymethyl cellulose, first, ethyl cellulose, low-substituted hydroxypropyl cellulose, magnesium stearate, Pulvis Talci etc., the Chinese medicine composition of the suitable clinical practice of making comprises powder, granule, capsule, tablet etc.
Chinese medicine composition of the present invention be by a certain proportion of Chinese crude drug by special process preparation and powder, granule, capsule, tablet etc.Can promoting blood circulation to remove obstruction in the collateral, dispelling wind and relieving pain, have evident in efficacy, good analgesic effect, easy to carry, characteristics such as have no side effect, and be applicable to all kinds of headache patients, be the migrainous first-selected preparation of a kind of treatment.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment 1: a kind ofly be used for the treatment of migrainous powder
Prescription is combined as:
Rhizoma Chuanxiong 110g Radix Bupleuri 110g Rhizoma Pinelliae 110g
Rhizoma Gastrodiae 110g Radix Angelicae Dahuricae 80g Flos Lonicerae 180g
Radix Scutellariae 100g Herba Asari 80g Radix Glycyrrhizae 80g
Radix Angelicae Sinensis 80g Flos Chrysanthemi 180g Semen Persicae 80g
Preparation method is:
(1) get Rhizoma Chuanxiong, each 110g of Radix Bupleuri, the Radix Angelicae Dahuricae, each 80g mixing of Radix Angelicae Sinensis, soak and spend the night, sealing was distilled 8 hours, extracted volatile oil; After getting beta-schardinger dextrin-and water and grinding well, the alcoholic solution that adds volatile oil grinds to form pastel in mortar, lyophilization, Benexate Hydrochloride, standby;
(2) get the Rhizoma Pinelliae, each 110g of Rhizoma Gastrodiae, Flos Lonicerae, each 180g of Flos Chrysanthemi, Semen Persicae 80g and above-mentioned medicinal residues and mix, decoct with water each 1.5 hours 3 times, merge decocting liquid, filter, 70 ℃ of reclaim under reduced pressure are concentrated into about 700ml, the ethanol that adds 700ml, in 3～5 ℃ leave standstill 12 hours after, centrifugal, get supernatant, decompression recycling ethanol also is concentrated into extractum, takes out cold drying, be ground into fine powder, standby;
(3) get Radix Scutellariae 100g, Herba Asari 80g, Radix Glycyrrhizae 80g, add 90% alcohol reflux 4 times, each 1 hour, merge extractive liquid, filters, and is evaporated to extractum, takes out, and is dried to dried cream, is ground into fine powder, and was standby;
(4) get above-mentioned Benexate Hydrochloride, two fine powder mixings, dry below 50 ℃, make the powder of taking in supplying.
Embodiment 2: a kind ofly be used for the treatment of migrainous tablet
Prescription is combined as:
Rhizoma Chuanxiong 80g Radix Bupleuri 80g Rhizoma Pinelliae 80g
Rhizoma Gastrodiae 80g Radix Angelicae Dahuricae 50g Flos Lonicerae 100g
Radix Scutellariae 80g Herba Asari 50g Radix Glycyrrhizae 50g
Radix Angelicae Sinensis 50g Flos Chrysanthemi 100g Semen Persicae 50g
Preparation method is:
(1) get Rhizoma Chuanxiong, each 80g of Radix Bupleuri, the Radix Angelicae Dahuricae, each 50g mixing of Radix Angelicae Sinensis, soak and spend the night, sealing was distilled 6 hours, extracted volatile oil; After getting beta-schardinger dextrin-and water and grinding well, the alcoholic solution that adds volatile oil grinds to form pastel in mortar, lyophilization, Benexate Hydrochloride, standby;
(2) get the Rhizoma Pinelliae, each 80g of Rhizoma Gastrodiae, Flos Lonicerae, each 100g of Flos Chrysanthemi, Semen Persicae 50g and above-mentioned medicinal residues and mix, decoct with water each 1 hour 4 times, merge decocting liquid, filter, 70 ℃ of reclaim under reduced pressure are concentrated into about 600ml, the ethanol that adds 600ml, in 3～5 ℃ leave standstill 12 hours after, centrifugal, get supernatant, decompression recycling ethanol also is concentrated into extractum, takes out cold drying, be ground into fine powder, standby;
(3) get Radix Scutellariae 80g, Herba Asari 50g, Radix Glycyrrhizae 50g, add 85% alcohol reflux 3 times, each 1 hour, merge extractive liquid, filters, and is evaporated to extractum, takes out, and is dried to dried cream, is ground into fine powder, and was standby;
(4) get above-mentioned Benexate Hydrochloride, two fine powder mixings, dry below 50 ℃, add the about 130g of starch, lactose 63g, calcium hydrogen phosphate 35g, low-substituted hydroxypropyl cellulose 22g, magnesium stearate 11g, mixing, direct compression, coating gets tablet.
Embodiment 3: a kind ofly be used for the treatment of migrainous capsule
Prescription is combined as:
Rhizoma Chuanxiong 65g Radix Bupleuri 65g Rhizoma Pinelliae 65g
Rhizoma Gastrodiae 65g Radix Angelicae Dahuricae 50g Flos Lonicerae 85g
Radix Scutellariae 60g Herba Asari 50g Radix Glycyrrhizae 50g
Radix Angelicae Sinensis 50g Flos Chrysanthemi 85g Semen Persicae 50g
Preparation method is:
(1) get Rhizoma Chuanxiong, each 65g of Radix Bupleuri, the Radix Angelicae Dahuricae, each 50g of Radix Angelicae Sinensis, mix, soak and spend the night, sealing was distilled 5 hours, extracted volatile oil; After getting beta-schardinger dextrin-and water and grinding well, the alcoholic solution that adds volatile oil grinds to form pastel in mortar, lyophilization, Benexate Hydrochloride, standby;
(2) get the Rhizoma Pinelliae, each 65g of Rhizoma Gastrodiae, Flos Lonicerae, each 85g of Flos Chrysanthemi, Semen Persicae 50g and above-mentioned medicinal residues and mix, decoct with water each 1 hour 3 times, merge decocting liquid, filter, 70 ℃ of reclaim under reduced pressure are concentrated into 500ml, the ethanol that adds 500ml, in 3～5 ℃ leave standstill 12 hours after, centrifugal, get supernatant, decompression recycling ethanol also is concentrated into extractum, takes out cold drying, be ground into fine powder, standby;
(3) get Radix Scutellariae 60g, Herba Asari 50g, Radix Glycyrrhizae 50g, add alcohol reflux 2 times, each 1 hour, merge extractive liquid, filters, and is evaporated to extractum, takes out, and is dried to dried cream, is ground into fine powder, and was standby;
(4) get above-mentioned Benexate Hydrochloride, two fine powder mixings, dry below 50 ℃, the about 180g of mixture of starch-sucrose (ratio is 5: 1), mixing, encapsulated, get capsule.
Embodiment 4: a kind ofly be used for the treatment of migrainous granule
Prescription is combined as:
Rhizoma Chuanxiong 130g Radix Bupleuri 130g Rhizoma Pinelliae 130g
Rhizoma Gastrodiae 130g Radix Angelicae Dahuricae 100g Flos Lonicerae 200g
Radix Scutellariae 120g Herba Asari 100g Radix Glycyrrhizae 100g
Radix Angelicae Sinensis 100g Flos Chrysanthemi 200g Semen Persicae 100g
Preparation method is:
(1) get Rhizoma Chuanxiong, each 130g of Radix Bupleuri, the Radix Angelicae Dahuricae, each 100g of Radix Angelicae Sinensis, mix, soak and spend the night, sealing was distilled 8 hours, extracted volatile oil; After getting beta-schardinger dextrin-and water and grinding well, the alcoholic solution that adds volatile oil grinds to form pastel in mortar, lyophilization, Benexate Hydrochloride, standby;
(2) get the Rhizoma Pinelliae, each 130g of Rhizoma Gastrodiae, Flos Lonicerae, each 200g of Flos Chrysanthemi, Semen Persicae 100g and above-mentioned medicinal residues and mix, decoct with water each 1 hour 5 times, merge decocting liquid, filter, 70 ℃ of reclaim under reduced pressure are concentrated into 800ml, the ethanol that adds 800ml, in 3～5 ℃ leave standstill 12 hours after, centrifugal, get supernatant, decompression recycling ethanol also is concentrated into extractum, takes out cold drying, be ground into fine powder, standby;
(3) get Radix Scutellariae 120g, Herba Asari 100g, Radix Glycyrrhizae 100g, add 90% alcohol reflux 4 times, each 1 hour, merge extractive liquid, filters, and is evaporated to extractum, takes out, and is dried to dried cream, is ground into fine powder, and was standby;
(4) get above-mentioned Benexate Hydrochloride, two fine powder mixings, dry below 50 ℃, add the about 235g of cane sugar powder, the about 136g of dextrin, the about 49g of Pulvis Talci, mix homogeneously, behind alcohol granulation, granulate gets granule.
Claims (5)
1, a kind ofly be used for the treatment of migrainous Chinese medicine composition, it is characterized in that it is formed for the raw material prescription by the Chinese medicine of following weight by part:
80～150 parts of 80～150 parts of Rhizoma Pinelliaes of 80～150 parts of Radix Bupleuri of Rhizoma Chuanxiong
100～200 parts of 50～100 portions of Flos Loniceraes of 80～150 parts of Radixs Angelicae Dahuricae of Rhizoma Gastrodiae
50～100 parts in 50～100 portions of Radix Glycyrrhizaes of 80～150 parts of Herba Asaris of Radix Scutellariae
50～100 parts in 100～200 parts of Semen Persicaes of 50～100 parts of Flos Chrysanthemis of Radix Angelicae Sinensis.
2, a kind of migrainous Chinese medicine composition that is used for the treatment of as claimed in claim 1, the weight proportion of each Chinese medicine is in the side of it is characterized in that:
110 parts of 110 parts of Rhizoma Pinelliaes of 110 parts of Radix Bupleuri of Rhizoma Chuanxiong
180 parts of 80 portions of Flos Loniceraes of 110 parts of Radixs Angelicae Dahuricae of Rhizoma Gastrodiae
80 parts in 80 portions of Radix Glycyrrhizaes of 100 parts of Herba Asaris of Radix Scutellariae
80 parts in 180 parts of Semen Persicaes of 80 parts of Flos Chrysanthemis of Radix Angelicae Sinensis.
3, as the described a kind of migrainous Chinese medicine composition that is used for the treatment of of claim 1-2, it is characterized in that the preparation method of this Chinese medicine composition is:
(1) get Rhizoma Chuanxiong, Radix Bupleuri, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis mixing, soak and spend the night, sealing was distilled 5～8 hours, extracted volatile oil; After getting beta-schardinger dextrin-and water and grinding well, the alcoholic solution that adds volatile oil grinds to form pastel in mortar, lyophilization, Benexate Hydrochloride, standby;
(2) get the Rhizoma Pinelliae, Rhizoma Gastrodiae, Flos Lonicerae, Flos Chrysanthemi, Semen Persicae and above-mentioned medicinal residues and mix, decoct with water each 1～2 hour 3～5 times, merge decocting liquid, filter, 70 ℃ of reclaim under reduced pressure are concentrated in right amount, the ethanol that adds equivalent, in 3～5 ℃ leave standstill 12 hours after, centrifugal, get supernatant, decompression recycling ethanol also is concentrated into extractum, takes out cold drying, be ground into fine powder, standby;
(3) get Radix Scutellariae, Herba Asari, Radix Glycyrrhizae, add 80～100% alcohol reflux 2～4 times, each 1 hour, merge extractive liquid, filters, and is evaporated to extractum, takes out, and is dried to dried cream, is ground into fine powder, and was standby;
(4) get above-mentioned Benexate Hydrochloride, two fine powder mixings, dry below 50 ℃, and/or add suitable pharmaceutics adjuvant, the Chinese medicine composition of the suitable clinical practice of making.
4, a kind of migrainous Chinese medicine composition that is used for the treatment of as claimed in claim 3 is characterized in that the pharmaceutics adjuvant that suits comprises: starch, dextrin, sucrose, lactose, calcium hydrogen phosphate, sodium carboxymethyl cellulose, first, ethyl cellulose, low-substituted hydroxypropyl cellulose, magnesium stearate, Pulvis Talci etc.
5, a kind of migrainous Chinese medicine composition that is used for the treatment of as claimed in claim 3, the dosage form that it is characterized in that this Chinese medicine composition is powder, granule, capsule, tablet etc.
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| CNA2008101034137A CN101549105A (en) | 2008-04-03 | 2008-04-03 | Traditional Chinese medicine composition for treating migraine |
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| CNA2008101034137A CN101549105A (en) | 2008-04-03 | 2008-04-03 | Traditional Chinese medicine composition for treating migraine |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984993A (en) * | 2010-07-02 | 2011-03-16 | 荣成市科学技术情报研究所 | Chinese medicament for treating qi stagnation and blood stasis headache |
| CN103417945A (en) * | 2013-08-20 | 2013-12-04 | 付蓉 | Drug for treatment of migraine |
| CN103990100A (en) * | 2014-06-13 | 2014-08-20 | 广西中医药大学 | Traditional Chinese medicinal composition for treating migraine |
| CN104258109A (en) * | 2014-10-09 | 2015-01-07 | 王健 | Traditional Chinese medicine compound preparation for treating migraine disease and preparation method thereof |
| CN105031303A (en) * | 2015-07-01 | 2015-11-11 | 路贝贝 | Drug for treating migraine |
| CN105582189A (en) * | 2016-02-24 | 2016-05-18 | 李莉 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN107397950A (en) * | 2017-07-28 | 2017-11-28 | 刘道鹏 | A kind of antimigraine electuary |
-
2008
- 2008-04-03 CN CNA2008101034137A patent/CN101549105A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984993A (en) * | 2010-07-02 | 2011-03-16 | 荣成市科学技术情报研究所 | Chinese medicament for treating qi stagnation and blood stasis headache |
| CN101984993B (en) * | 2010-07-02 | 2012-03-28 | 张全霞 | Chinese medicament for treating qi stagnation and blood stasis headache |
| CN103417945A (en) * | 2013-08-20 | 2013-12-04 | 付蓉 | Drug for treatment of migraine |
| CN103417945B (en) * | 2013-08-20 | 2015-11-25 | 潘德利 | A kind of medicine for the treatment of migraine |
| CN103990100A (en) * | 2014-06-13 | 2014-08-20 | 广西中医药大学 | Traditional Chinese medicinal composition for treating migraine |
| CN104258109A (en) * | 2014-10-09 | 2015-01-07 | 王健 | Traditional Chinese medicine compound preparation for treating migraine disease and preparation method thereof |
| CN105031303A (en) * | 2015-07-01 | 2015-11-11 | 路贝贝 | Drug for treating migraine |
| CN105582189A (en) * | 2016-02-24 | 2016-05-18 | 李莉 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN107397950A (en) * | 2017-07-28 | 2017-11-28 | 刘道鹏 | A kind of antimigraine electuary |
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Open date: 20091007 |