CN105106663A - Pharmaceutical preparation for treating arrhythmia - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a pharmaceutical preparation for treating arrhythmia. The preparation is prepared from raw materials as follows: 20 parts of clerodendron trichotomum, 25 parts of euphorbia hypericifolia, 28 parts of nervilia fordii, 15 parts of Angiopteris magna Ching, 25 parts of Chinese angelica, 28 parts of red peony roots, 15 parts of cassia twigs, 25 parts of suberect spatholobus stems, 20 parts of rhodiola rosea, 25 parts of grassleaf sweetflag rhizomes, 20 parts of danshen roots, 25 parts of poria cocos, 20 parts of largehead atractylodes rhizomes, 15 parts of ephedra herbs, 15 parts of pyrrosia leaves, 15 parts of cowherb seeds, 25 parts of platycodon roots, 15 parts of milkvetch roots and 5 parts of liquorice roots. The preparation can treat the arrhythmia.

Description

One is used for the treatment of ARR pharmaceutical preparation

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of ARR pharmaceutical preparation and its preparation method and application.

Background technology

Arrhythmia is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node; exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Arrhythmia is one group of disease important in cardiovascular disease.It can be fallen ill separately and also can occur together with cardiovascular diseases.Can break out and cause sudden death, also sustainablely involve heart and cause its exhaustion.For this reason, be bursting to develop and manyly treat the needs that ARR medicine meets clinical treatment safely and effectively.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of cardiac arrhythmia.In order to reach this object, adopt following technical scheme:

Technical scheme: one is used for the treatment of ARR pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: clerodendron trichotomum 20 parts, logical Herba Euphorbiae Humifusae 25 parts, Folium Nerviliae fordii 28 parts, large Rhizoma Angiopteridis Fokiensis 15 parts, Radix Angelicae Sinensis 25 parts, Radix Paeoniae Rubra 28 parts, Ramulus Cinnamomi 15 parts, Caulis Spatholobi 25 parts, Radix Rhodiolae 20 parts, Rhizoma Acori Graminei 25 parts, Radix Salviae Miltiorrhizae 20 parts, 25 parts, Poria, the Rhizoma Atractylodis Macrocephalae 20 parts, 15 parts, Herba Ephedrae, Folium Pyrrosiae 15 parts, Semen Vaccariae 15 parts, Radix Platycodonis 25 parts, the Radix Astragali 15 parts, 5 parts, Radix Glycyrrhizae.

Describedly be used for the treatment of ARR pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.

Describedly be used for the treatment of ARR pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

Described be used for the treatment of ARR pharmaceutical preparation preparation treatment antiarrhythmic medicament in application.

Clerodendron trichotomum, Latin is called ClerodendrumtrichotomumThunb. root, stem, leaf, spends and be used as medicine, remove rheumatism, blood pressure lowering.Root, leaf: rheumatic arthritis, hypertension, dysentery, malaria.Leaf: the tinea manuum is controlled in external, paddy-field dermatitis, eczema, hemorrhoid.The present invention is with all herbal medicine.

Logical Herba Euphorbiae Humifusae, formal name used at school: Euphorbiahypericifolia is the plant of Euphorbiaceae Euphorbia.Be distributed in the ground such as Hainan, Jiangxi, Sichuan, Guizhou, Hunan, Guangxi, Guangdong, Yunnan of the torrid zone, the island of Taiwan, subtropical zone and China's Mainland, be grown on height above sea level 30 meters to 2, the area of 100 meters, normal growth is in shrubbery, wasteland, wilderness, roadside or field, at present by artificial introducing and planting: clearing away heat-damp and promoting diuresis, restrain antipruritic.Bacillary dysentery, enteritis, diarrhea, bleeding hemorrhoids; Eczema is controlled in external, allergic dermatitis, skin pruritus.The present invention is with all herbal medicine.

Folium Nerviliae fordii is the orchid family Nervilia plant Nervilia fordii Nerviliafordii (Hance) Schlecht., is used as medicine with herb or tuber.Clearing away lung-heat to relieve cough, spleen invigorating removing food stagnancy, sedation-analgesia, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pulmonary tuberculosis cough spitting of blood, bronchitis, infantile malnutrition, infantile pneumonia, psychosis, treating swelling and pain by traumatic injury, stomatitis, acute laryngitis, sore.The present invention is with all herbal medicine.

Large Rhizoma Angiopteridis Fokiensis is fern Angiopteridaceae lotus throne Cyclosorus plant large lotus throne Herba pteridii latiusculi AngiopterismagnaChing, is used as medicine with the root stock with petiole.The whole year can adopt, and clean section is dried, or levigation is for subsequent use.Blood stasis removing stops blooding, removing toxic substances.For traumatic injury, dysfunctional uterine hemorrhage; Venom is controlled in external, furuncle, wound hemorrhage.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science is thought, arrhythmia belongs to for " cardiopalmus " or " palpitation with a distress feeling ", clerodendron trichotomum of the present invention, logical Herba Euphorbiae Humifusae, Folium Nerviliae fordii, large Rhizoma Angiopteridis Fokiensis, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Ramulus Cinnamomi, Caulis Spatholobi, Radix Rhodiolae heat-clearing and toxic substances removing, benefiting QI and nourishing blood, nourishing yin and warming yang are monarch drug, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, Poria, the Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Folium Pyrrosiae, Semen Vaccariae, Radix Platycodonis, the Radix Astragali, Radix Glycyrrhizae regulating qi to disperse stagnation, to reduce phlegm by drink as ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, benefiting QI and nourishing blood, nourishing yin and warming yang, regulating qi to disperse stagnation, reduce phlegm by drink, treatment arrhythmia successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get clerodendron trichotomum 20g, logical Herba Euphorbiae Humifusae 25g, Folium Nerviliae fordii 28g, large Rhizoma Angiopteridis Fokiensis 15g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 28g, Ramulus Cinnamomi 15g, Caulis Spatholobi 25g, Radix Rhodiolae 20g, Rhizoma Acori Graminei 25g, Radix Salviae Miltiorrhizae 20g, Poria 25g, Rhizoma Atractylodis Macrocephalae 20g, Herba Ephedrae 15g, Folium Pyrrosiae 15g, Semen Vaccariae 15g, Radix Platycodonis 25g, Radix Astragali 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get clerodendron trichotomum 20g, logical Herba Euphorbiae Humifusae 25g, Folium Nerviliae fordii 28g, large Rhizoma Angiopteridis Fokiensis 15g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 28g, Ramulus Cinnamomi 15g, Caulis Spatholobi 25g, Radix Rhodiolae 20g, Rhizoma Acori Graminei 25g, Radix Salviae Miltiorrhizae 20g, Poria 25g, Rhizoma Atractylodis Macrocephalae 20g, Herba Ephedrae 15g, Folium Pyrrosiae 15g, Semen Vaccariae 15g, Radix Platycodonis 25g, Radix Astragali 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get clerodendron trichotomum 20g, logical Herba Euphorbiae Humifusae 25g, Folium Nerviliae fordii 28g, large Rhizoma Angiopteridis Fokiensis 15g, Radix Angelicae Sinensis 25g, Radix Paeoniae Rubra 28g, Ramulus Cinnamomi 15g, Caulis Spatholobi 25g, Radix Rhodiolae 20g, Rhizoma Acori Graminei 25g, Radix Salviae Miltiorrhizae 20g, Poria 25g, Rhizoma Atractylodis Macrocephalae 20g, Herba Ephedrae 15g, Folium Pyrrosiae 15g, Semen Vaccariae 15g, Radix Platycodonis 25g, Radix Astragali 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, the present invention studies the controlling experiment of arrhythmia rat model

Male SD rat 24, body weight 180-220g, is divided into model control group and treatment group at random, often organizes 12.Two groups of rats give corresponding tested material as follows:

Model control group: give to wait capacity purified water gavage, every day 1 time, continuous 1 week gavage.

Treatment group: give embodiment 1 clear paste powder prepared by process for producing granula, by the dosage gavage of 80mg/kg body weight, every day 1 time, continuous 1 week gastric infusion.

30min after last medicine, with 10% chloral hydrate anesthesia (3.5mL/kg), connects electrocardiograph, record normal ECG, sublingual vein injection barium chloride 4mg/kg, arrhythmia time of occurrence, persistent period and arrhythmia generation number after observation administration.

Result of the test shows, and intravenous injection calcium chloride can bring out ventricular premature contraction (VP) or quiver (VF) in room, and incidence rate is 100%; Treatment group compares the incidence rate that obviously can reduce VP, VF with model group, postpone arrhythmia time of origin and shorten the arrhythmia persistent period, this imply that pharmaceutical preparation of the present invention has the arrhythogenic effect of anti-barium chloride, the results are shown in Table 1.

After table 1 liang group rat modeling, ARR time of origin and persistent period compare

Group	Sample size (only)	Time of origin (s)	Persistent period (s)
				Model control group	12	10.5±3.3	249.7±32.4
Treatment group	12	78.1±5.2*	128.5±27.4*

Compare with model control group, * p<0.01.

Claims (4)

1. one kind is used for the treatment of ARR pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: clerodendron trichotomum 20 parts, logical Herba Euphorbiae Humifusae 25 parts, Folium Nerviliae fordii 28 parts, large Rhizoma Angiopteridis Fokiensis 15 parts, Radix Angelicae Sinensis 25 parts, Radix Paeoniae Rubra 28 parts, Ramulus Cinnamomi 15 parts, Caulis Spatholobi 25 parts, Radix Rhodiolae 20 parts, Rhizoma Acori Graminei 25 parts, Radix Salviae Miltiorrhizae 20 parts, 25 parts, Poria, the Rhizoma Atractylodis Macrocephalae 20 parts, 15 parts, Herba Ephedrae, Folium Pyrrosiae 15 parts, Semen Vaccariae 15 parts, Radix Platycodonis 25 parts, the Radix Astragali 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of ARR pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of ARR pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of ARR pharmaceutical preparation in treatment antiarrhythmic medicament according to claim 1.