CN105031481A - Pharmaceutic preparation for treating neurasthenia - Google Patents

Pharmaceutic preparation for treating neurasthenia Download PDF

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Publication number
CN105031481A
CN105031481A CN201510600726.3A CN201510600726A CN105031481A CN 105031481 A CN105031481 A CN 105031481A CN 201510600726 A CN201510600726 A CN 201510600726A CN 105031481 A CN105031481 A CN 105031481A
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parts
treatment
radix
medicine
rhizoma
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CN201510600726.3A
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Chinese (zh)
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孙本如
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Quanjiao Xianqi Pharmaceutical Technology Co Ltd
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Quanjiao Xianqi Pharmaceutical Technology Co Ltd
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Abstract

The invention belongs to the field of Chinese materia medica preparations and particularly provides a pharmaceutic preparation for treating neurasthenia. The pharmaceutic preparation is made from 20 parts of ruellia neesiana, 25 parts of geum aleppicum, 18 parts of dwarf galangal rhizome, 25 parts of buttonbush, 25 parts of roots of red-rooted salvia, 28 parts of astragalus membranaceus, 15 parts of spina date seeds, 15 parts of polygala tenuifolia, 20 parts of rhizoma acori graminei, 25 parts of schisandra chinensis, 20 parts of poria with hostwood, 25 parts of fruits of Chinese wolfberry, 20 parts of semen coicis, 15 parts of dogwood, 15 parts of chrysanthemums, 15 parts of uncaria, 25 parts of tuber fleeceflower stems, 15 parts of caulis spatholobi and 5 parts of liquorice. The pharmaceutic preparation is capable of treating neurasthenia.

Description

One is used for the treatment of neurasthenic pharmaceutical preparation
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of neurasthenic pharmaceutical preparation and its preparation method and application.
Background technology
Neurasthenia is a more wide in range appellation, calls it at present like this and comprises a part depression, anxiety disorder, tension headache, insomnia, dyspepsia etc.It refers to, due under being in nervous and pressure for a long time, occur spirit easily excitement and mental easy tired phenomenon, often with emotion worry, irritability, sleep disorder, muscle tone pain etc.; These symptoms can not be attributed to brain, physical disease and other mental sickness.Heavy time light during symptom, fluctuate relevant with psychosocial factor, the many delays of the course of disease.Current Most scholars thinks that Nervous and Mental Factors causes neurasthenic main cause.More every factors that can cause lasting buck fever and long-term intrapsychic conflict, make strong and lasting in tension of neural activity process, exceed the tolerance limit of nervous system tension force, neurasthenia can occur.As overtired and to can not get rest be overstrain of excitatory process; Dissatisfied to present situation is then overstrain of inhibitory process; Frequent change living environment and don't adaptation, the activity of central nervous system, plays a leading role in body Activities.And corticocerebral neurocyte has quite high toleration, generally and be not easy to cause neurasthenia or exhaustion.After the mental work of anxiety, although the fatigue of creating, just can recover after pausing to have a rest or sleep, but the neural activity of strong tense situation, once surmount tolerance limit, just may produce neurasthenia.For this reason, be bursting to develop and manyly treat the needs that neurasthenic medicine meets clinical treatment safely and effectively.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of neurasthenia.In order to reach this object, adopt following technical scheme:
Technical scheme: one is used for the treatment of neurasthenic pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma seu herba Asystasiellae Chinensis 20 parts, geum aleppicum 25 parts, Rhizoma alpiniae pumilae 18 parts, buttonbush 25 parts, Radix Salviae Miltiorrhizae 25 parts, the Radix Astragali 28 parts, Semen Ziziphi Spinosae 15 parts, Radix Polygalae 15 parts, Rhizoma Acori Graminei 20 parts, Fructus Schisandrae Chinensis 25 parts, Poria cum Radix Pini 20 parts, Fructus Lycii 25 parts, Semen Coicis 20 parts, Fructus Corni 15 parts, Flos Chrysanthemi 15 parts, Ramulus Uncariae Cum Uncis 15 parts, Caulis Polygoni Multiflori 25 parts, Caulis Spatholobi 15 parts, 5 parts, Radix Glycyrrhizae.
Describedly be used for the treatment of neurasthenic pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.
Describedly be used for the treatment of neurasthenic pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
Describedly be used for the treatment of the application of neurasthenic pharmaceutical preparation in preparation treatment neurasthenia medicine.
Rhizoma seu herba Asystasiellae Chinensis, Classification system: Asystasiellaneesiana (Wall.) Lindau, for Acanthaceae Rhizoma seu herba Asystasiellae Chinensis belongs to herbaceous plant.White, rich mucus, blade papery, Hua Dansheng or to life; Corolla lilac red.Medicinal source is rhizome or the herb of Rhizoma seu herba Asystasiellae Chinensis.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, diuresis.For pulmonary tuberculosis, laryngopharynx swelling and pain, diabetes, ascites; Traumatic hemorrhage is controlled in external, sprains, furuncle and phyma.The present invention adopts all herbal medicine.
Geum aleppicum is Rosaceae avens geum aleppicum GeumaleppicumJacq., is used as medicine with herb or root.Summer excavates, and chopping is dried.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For enteritis, dysentery, infantile convulsion, lumbago and skelalgia, traumatic injury, menoxenia, leucorrhea; Furuncle is controlled in external, carbuncle.The present invention is with all herbal medicine.
Rhizoma alpiniae pumilae is Zingiberaceae Alpinia plants Huashan Rhizoma Zingiberis Recens AlpiniachinensisRosc., is used as medicine with root stock.Summer excavates, and cleans and dries.Pungent, temperature.Expelling wind and removing dampness, vital energy regualting and blood circulation-promoting, removing toxic substances, pain relieving.Relieving cough and asthma, dispersing cold for relieving pain, except rheumatism, separates sore.For wind and cold cough with asthma, peratodynia, Fengshi Guanjie pain, falls and damages blood stasis stagnation, menoxenia, innominate toxic swelling.
Buttonbush is Rubiaceae Cephalanthus plant buttonbush CephalanthusnaucleoidesDC. [C.occidentalisauct.NonL.], is used as medicine with root, leaf and inflorescence.Xia Qiu gathers, and cleans, using fresh herb or dry.Root: heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasia and promoting granulation, expelling phlegm for arresting cough.For influenza, upper respiratory tract infection, laryngopharynx swelling and pain, pneumonia, cough, orchitis, parotitis, mastitis; Traumatic injury is controlled in external, furuncle and phyma, fracture (or with root bark steeping in wine 1 ~ 2 day, dry grind into powder deposited, can hemostasis and pain-relieving).Inflorescence: clearing away heat-damp and promoting diuresis.For enteritis, bacillary dysentery.Leaf: heat-clearing and toxic substances removing.Traumatic injury is controlled in external, fracture.The present invention is used as medicine with root.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, neurasthenia belongs to the category such as " melancholia ", " being insomnia ", " cardiopalmus " of the traditional Chinese medical science, Rhizoma seu herba Asystasiellae Chinensis of the present invention, geum aleppicum, Rhizoma alpiniae pumilae, buttonbush, Radix Salviae Miltiorrhizae, the Radix Astragali, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Poria cum Radix Pini's heat-clearing and toxic substances removing, tranquillizing and allaying excitement are monarch drug, Fructus Lycii, Semen Coicis, Fructus Corni, Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Caulis Polygoni Multiflori, Caulis Spatholobi depressed liver-energy dispersing and QI regulating, wind-dispelling heat-dissipating are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment neurasthenia successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Rhizoma seu herba Asystasiellae Chinensis 20g, geum aleppicum 25g, Rhizoma alpiniae pumilae 18g, buttonbush 25g, Radix Salviae Miltiorrhizae 25g, Radix Astragali 28g, Semen Ziziphi Spinosae 15g, Radix Polygalae 15g, Rhizoma Acori Graminei 20g, Fructus Schisandrae Chinensis 25g, Poria cum Radix Pini 20g, Fructus Lycii 25g, Semen Coicis 20g, Fructus Corni 15g, Flos Chrysanthemi 15g, Ramulus Uncariae Cum Uncis 15g, Caulis Polygoni Multiflori 25g, Caulis Spatholobi 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Rhizoma seu herba Asystasiellae Chinensis 20g, geum aleppicum 25g, Rhizoma alpiniae pumilae 18g, buttonbush 25g, Radix Salviae Miltiorrhizae 25g, Radix Astragali 28g, Semen Ziziphi Spinosae 15g, Radix Polygalae 15g, Rhizoma Acori Graminei 20g, Fructus Schisandrae Chinensis 25g, Poria cum Radix Pini 20g, Fructus Lycii 25g, Semen Coicis 20g, Fructus Corni 15g, Flos Chrysanthemi 15g, Ramulus Uncariae Cum Uncis 15g, Caulis Polygoni Multiflori 25g, Caulis Spatholobi 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Rhizoma seu herba Asystasiellae Chinensis 20g, geum aleppicum 25g, Rhizoma alpiniae pumilae 18g, buttonbush 25g, Radix Salviae Miltiorrhizae 25g, Radix Astragali 28g, Semen Ziziphi Spinosae 15g, Radix Polygalae 15g, Rhizoma Acori Graminei 20g, Fructus Schisandrae Chinensis 25g, Poria cum Radix Pini 20g, Fructus Lycii 25g, Semen Coicis 20g, Fructus Corni 15g, Flos Chrysanthemi 15g, Ramulus Uncariae Cum Uncis 15g, Caulis Polygoni Multiflori 25g, Caulis Spatholobi 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment neurasthenia of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation neurasthenia case 50 example, 35 ~ 64 years old age.The shortest person of the course of disease 1 month, most elder reaches 5 years.
4.2 diagnostic criterias: (1) head tonicity is uncomfortable: as dizziness, feeling of fullness in the head and headache etc.(2) sleep disorder: great majority are insomnias, and minority shows as drowsiness dreaminess, still tired after sleeping.(3) mental work rate declines: being mainly mental work can not be lasting, and attention can not be concentrated, memory disorder, is usually forgetful to general thing, and not easily forgets the thing of worry.(4) hyposthenia feeling of fatigue: show as general weakness, feeling of fatigue and labor intensity disproportionate.(5) mood is worried: be easily minor matter and excited, and with other Tenseness that mood worry causes, as nervous, inappetence etc.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: the transference cures such as tension headache, myalgia, sensory disturbance, emotion are tired.Effective: above-mentioned symptom is alleviated to some extent, physical recovery is healthy.Invalid: disease is unchanged.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Effectively Invalid Total effective rate (%)
Treatment group 20 4 15 1 95
Blank group 20 2 1 17 15
Visible, the medicine that the present invention obtains can safe and effective treatment neurasthenia, and has no side effect.

Claims (4)

1. one kind is used for the treatment of neurasthenic pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma seu herba Asystasiellae Chinensis 20 parts, geum aleppicum 25 parts, Rhizoma alpiniae pumilae 18 parts, buttonbush 25 parts, Radix Salviae Miltiorrhizae 25 parts, the Radix Astragali 28 parts, Semen Ziziphi Spinosae 15 parts, Radix Polygalae 15 parts, Rhizoma Acori Graminei 20 parts, Fructus Schisandrae Chinensis 25 parts, Poria cum Radix Pini 20 parts, Fructus Lycii 25 parts, Semen Coicis 20 parts, Fructus Corni 15 parts, Flos Chrysanthemi 15 parts, Ramulus Uncariae Cum Uncis 15 parts, Caulis Polygoni Multiflori 25 parts, Caulis Spatholobi 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of neurasthenic pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of neurasthenic pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of neurasthenic pharmaceutical preparation in treatment neurasthenia medicine according to claim 1.
CN201510600726.3A 2015-09-18 2015-09-18 Pharmaceutic preparation for treating neurasthenia Pending CN105031481A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105232960A (en) * 2015-11-15 2016-01-13 李洋 Medicine preparation for treating neurasthenia

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CN1686496A (en) * 2005-04-13 2005-10-26 蒋希民 Medicine for treating neurasthenia and its preparation method
CN101327296A (en) * 2008-07-23 2008-12-24 武汉理工大学 Compound Chinese medicine preparation for treating and improving insomnia and preparation method thereof
CN101549088A (en) * 2008-04-03 2009-10-07 北京中科仁和科技有限公司 Traditional Chinese medicine for treating neurasthenia and preparation method thereof
CN101632760A (en) * 2009-06-11 2010-01-27 杭州六易科技有限公司 Method for preparing tea for relieving uneasiness

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686496A (en) * 2005-04-13 2005-10-26 蒋希民 Medicine for treating neurasthenia and its preparation method
CN101549088A (en) * 2008-04-03 2009-10-07 北京中科仁和科技有限公司 Traditional Chinese medicine for treating neurasthenia and preparation method thereof
CN101327296A (en) * 2008-07-23 2008-12-24 武汉理工大学 Compound Chinese medicine preparation for treating and improving insomnia and preparation method thereof
CN101632760A (en) * 2009-06-11 2010-01-27 杭州六易科技有限公司 Method for preparing tea for relieving uneasiness

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伍冲寒: "逍遥散合归脾汤加减治疗神经衰弱32例临床观察", 《中医药导报》 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105232960A (en) * 2015-11-15 2016-01-13 李洋 Medicine preparation for treating neurasthenia

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