CN104922388A - Medicinal preparation for treating female climacteric syndromes - Google Patents
Medicinal preparation for treating female climacteric syndromes Download PDFInfo
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- CN104922388A CN104922388A CN201510420469.5A CN201510420469A CN104922388A CN 104922388 A CN104922388 A CN 104922388A CN 201510420469 A CN201510420469 A CN 201510420469A CN 104922388 A CN104922388 A CN 104922388A
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Abstract
The invention belongs to the field of medicine, and particularly provides a medicinal preparation for treating female climacteric syndromes. The medicinal preparation is prepared from the following raw materials of 20 parts of rhizomaparganii, 12 parts of celastrus flagellaris, 10 parts of pericarpium citri reticulatae, 10 parts of radix paeoniae alba, 10 parts of saposhnicovia divaricata, 15 parts of atractylodes macrocephala, 15 parts of Chinese yam, 10 parts of poria cocos, 15 parts of buerger pipewort flower, 15 parts of glossy privet fruit, 15 parts of eclipta alba, 10 parts of radix pueraiae, 15 parts of prunella vulgaris, 15 parts of radix pseudostellariae, 6 parts of scouring rush, 15 parts of cacumen biotae, 15 parts of folium mori and 10 parts of black sesame. The medicinal preparation can treat the female climacteric syndromes.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of female climacteric syndrome and its preparation method and application.
Background technology
Artificial menopause refers to excision bilateral ovaries or stops ovarian function with additive method, as radiotherapy and chemotherapy etc.Hysterectomize separately and retain side or bilateral ovaries person, not as artificial menopause.Female climacteric syndrome refers to occur before and after postmenopausal women gonadal hormone fluctuation or a series of based on function disorder of autonomic nervous system caused by reducing, with one group of syndrome of neuropsychological symptom.Menopause can be divided into natural menopause and artificial menopause two kinds.Natural menopause refers to that in ovary, follicle is used up, or remaining follicle loses reaction to promoting sexual gland hormone, and follicle is no longer grown and secreted estrogen, can not stimulate endometrial growth, cause menopause.Comparatively common clinically, because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of female climacteric syndrome safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of female climacteric syndrome disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of female climacteric syndrome, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: wild seat grass 20 parts, sting luxuriant Celastrus orbiculatus Thunb. 12 parts, Pericarpium Citri Reticulatae 10 parts, the Radix Paeoniae Alba 10 parts, Radix Saposhnikoviae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Dioscoreae 15 parts, 10 parts, Poria, Flos Eriocauli 15 parts, Fructus Ligustri Lucidi 15 parts, Herba Ecliptae 15 parts, Radix Puerariae 10 parts, Spica Prunellae 15 parts, Radix Pseudostellariae 15 parts, Herba Equiseti Hiemalis 6 parts, Cacumen Platycladi 15 parts, 15 parts, Folium Mori, Semen Sesami Nigrum 10 parts.
The described pharmaceutical preparation being used for the treatment of female climacteric syndrome, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of female climacteric syndrome, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment female climacteric syndrome medicine being used for the treatment of female climacteric syndrome.
Wild seat grass is Cyperaceae Cyperus plant cyperus iria Cyperus iria L., with all herbal medicine.Xia Qiu gathers, using fresh herb or dry.Expelling wind and removing dampness, regulating menstruation diuresis.For rheumatism bones and muscles pain, traumatic injury, menoxenia, dysmenorrhea, amenorrhea, lithangiuria.
Sting the fruit that luxuriant Celastrus orbiculatus Thunb. is Celastraceae plant Radix Seu Caulis Celastri Flagellaris Celastrus flagellaris Rupr., wind-damp dispelling, promoting blood circulation and stopping pain.For rheumatic arthritis, traumatic injury.All the other medical materials are pharmacopeia kind.
Beneficial effect: the wild seat grass of the present invention, sting luxuriant Celastrus orbiculatus Thunb., Pericarpium Citri Reticulatae, the Radix Paeoniae Alba, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing is monarch drug, Poria, Flos Eriocauli, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Pseudostellariae, Herba Equiseti Hiemalis, Cacumen Platycladi, Folium Mori, Semen Sesami Nigrum nourishing the liver and kidney, tranquillizing and allaying excitement, supplementing QI for promoting the production of body fluid is ministerial drug, Radix Puerariae, Spica Prunellae are adjuvant, mutual compatibility, treatment female climacteric syndrome successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get wild seat grass 20g, sting luxuriant Celastrus orbiculatus Thunb. 12g, Pericarpium Citri Reticulatae 10g, Radix Paeoniae Alba 10g, Radix Saposhnikoviae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 15g, Poria 10g, Flos Eriocauli 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Radix Puerariae 10g, Spica Prunellae 15g, Radix Pseudostellariae 15g, Herba Equiseti Hiemalis 6g, Cacumen Platycladi 15g, Folium Mori 15g, Semen Sesami Nigrum 10g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get wild seat grass 20g, sting luxuriant Celastrus orbiculatus Thunb. 12g, Pericarpium Citri Reticulatae 10g, Radix Paeoniae Alba 10g, Radix Saposhnikoviae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 15g, Poria 10g, Flos Eriocauli 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Radix Puerariae 10g, Spica Prunellae 15g, Radix Pseudostellariae 15g, Herba Equiseti Hiemalis 6g, Cacumen Platycladi 15g, Folium Mori 15g, Semen Sesami Nigrum 10g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get wild seat grass 20g, sting luxuriant Celastrus orbiculatus Thunb. 12g, Pericarpium Citri Reticulatae 10g, Radix Paeoniae Alba 10g, Radix Saposhnikoviae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Dioscoreae 15g, Poria 10g, Flos Eriocauli 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Radix Puerariae 10g, Spica Prunellae 15g, Radix Pseudostellariae 15g, Herba Equiseti Hiemalis 6g, Cacumen Platycladi 15g, Folium Mori 15g, Semen Sesami Nigrum 10g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment female climacteric syndrome of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation female climacteric syndrome 80 cases, wherein, 45 ~ 48 years old age.The shortest person of the course of disease 6 months, most elder reaches 2 years, average 1.2 years, wherein treatment group 40 example, blank group 40 example.
4.2 diagnostic criterias: (1) menoxenia: be climacteric women the most generally, the most outstanding performance.Menstruation often postpones, and even some months is just risen once, also reduces gradually through amount.When estrogen is fewer and feweri, when endometrium can not have been caused to change, menstruation just stopped, and is called menopause.(2) battle array hot flush: be climacteric one of principal character, some women within climacteric because estrogenic level declines, in blood, calcium level also declines to some extent, have a burst of position to generate heat, blush, perspire, with dizzy, nervous, the persistent period be one or two minute or 12 minutes-15 minutes not etc.(3) cardiovascular and lipoidosis: coronary heart disease, diabetes may be occurred.(4) neural, mental disorder: the women had, blood pressure fluctuates comparatively obvious up and down, and instability of may being in a bad mood is emotional, personality change, hypomnesis etc.(5) motor system is degenerated: occur waist, back of the body limbs pain, scapulohumeral periarthritis, cervical spondylosis appear in some women.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) fully recovers: symptom and sign disappear.(2) take a turn for the better: symptom and sign alleviate or partial disappearance.(3) invalid: unchanged after treatment.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 40 | 15 | 22 | 3 | 92.5 |
| Blank group | 40 | 1 | 1 | 38 | 5 |
Visible, the medicine that the present invention obtains can safe and effective treatment female climacteric syndrome, and has no side effect in use procedure.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of female climacteric syndrome, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: wild seat grass 20 parts, sting luxuriant Celastrus orbiculatus Thunb. 12 parts, Pericarpium Citri Reticulatae 10 parts, the Radix Paeoniae Alba 10 parts, Radix Saposhnikoviae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Dioscoreae 15 parts, 10 parts, Poria, Flos Eriocauli 15 parts, Fructus Ligustri Lucidi 15 parts, Herba Ecliptae 15 parts, Radix Puerariae 10 parts, Spica Prunellae 15 parts, Radix Pseudostellariae 15 parts, Herba Equiseti Hiemalis 6 parts, Cacumen Platycladi 15 parts, 15 parts, Folium Mori, Semen Sesami Nigrum 10 parts.
2. be used for the treatment of the pharmaceutical preparation of female climacteric syndrome as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of female climacteric syndrome as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment female climacteric syndrome medicine of female climacteric syndrome according to claim 1.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148019A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating fractures |
| CN105148074A (en) * | 2015-09-29 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating diabetes |
| CN105148194A (en) * | 2015-09-25 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating acute cholecystitis |
| CN105148117A (en) * | 2015-09-29 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for invigorating spleen to promote digestion |
| CN105148068A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating gingivitis or periodontitis |
| CN105169182A (en) * | 2015-09-29 | 2015-12-23 | 南京晶云化工有限公司 | Pharmaceutic preparation for treating yang deficiency arthralgia |
| CN105250865A (en) * | 2015-09-29 | 2016-01-20 | 南京晶云化工有限公司 | Medicinal preparation for treating epigastric pain |
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| CN102872425A (en) * | 2012-10-26 | 2013-01-16 | 谢春红 | Chinese medicinal decoction for treating climacteric syndrome |
| CN104367765A (en) * | 2014-11-27 | 2015-02-25 | 李洋 | Traditional Chinese medicinal composition for treating depression as well as preparation method and application thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1602937A (en) * | 2004-08-25 | 2005-04-06 | 林淦生医药研究所（深圳）有限公司 | Beautifying and climacteric syndrome treating composition, its preparing process and usage |
| CN102872425A (en) * | 2012-10-26 | 2013-01-16 | 谢春红 | Chinese medicinal decoction for treating climacteric syndrome |
| CN104367765A (en) * | 2014-11-27 | 2015-02-25 | 李洋 | Traditional Chinese medicinal composition for treating depression as well as preparation method and application thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148194A (en) * | 2015-09-25 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating acute cholecystitis |
| CN105148019A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating fractures |
| CN105148068A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating gingivitis or periodontitis |
| CN105148074A (en) * | 2015-09-29 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating diabetes |
| CN105148117A (en) * | 2015-09-29 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for invigorating spleen to promote digestion |
| CN105169182A (en) * | 2015-09-29 | 2015-12-23 | 南京晶云化工有限公司 | Pharmaceutic preparation for treating yang deficiency arthralgia |
| CN105250865A (en) * | 2015-09-29 | 2016-01-20 | 南京晶云化工有限公司 | Medicinal preparation for treating epigastric pain |
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Application publication date: 20150923 |