CN104800681A - Traditional Chinese medicine composition for treating irregular menstruation - Google Patents
Traditional Chinese medicine composition for treating irregular menstruation Download PDFInfo
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- CN104800681A CN104800681A CN201510208086.1A CN201510208086A CN104800681A CN 104800681 A CN104800681 A CN 104800681A CN 201510208086 A CN201510208086 A CN 201510208086A CN 104800681 A CN104800681 A CN 104800681A
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Abstract
The invention provides a traditional Chinese medicine composition for treating irregular menstruation. The traditional Chinese medicine composition is prepared from the following raw materials: drymaria diandra, berchemia yunnanensis, poria cocos, orange peel and the like. The traditional Chinese medicine composition can be used for treating irregular menstruation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of menoxenia and its preparation method and application.
Background technology
Menoxenia Xi Shi gynecological common disease, shows as the exception of menstrual cycle or amount of bleeding, can accompany that the moon is premenstrual, menstrual period time stomachache and General Symptoms.The cause of disease may be organic disease or malfunction.For this reason, be bursting to and develop the needs that more medicines for the treatment of menoxenia safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of menoxenia disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of menoxenia, the active component contained by it is extracted by following weight crude drug and is prepared from: Drymaria diandra Blume 12 parts, public blue or green 10 parts of duck, 10 parts, Poria, Pericarpium Citri tangerinae 6 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Caulis Perillae 10 parts, Rhizoma Coptidis 4 parts, 40 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 10 parts, Poria cum Radix Pini 10 parts, the Radix Astragali 20 parts, Radix Codonopsis 20 parts, Fructus Setariae Germinatus 10 parts, Radix Saposhnikoviae 10 parts, Flos Rosae Rugosae 10 parts, Herba Ecliptae 10 parts, Endothelium Corneum Gigeriae Galli 10 parts, 6 parts, Radix Glycyrrhizae.
The described Chinese medicine composition being used for the treatment of menoxenia, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of menoxenia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of Chinese medicine composition in preparation treatment menoxenia medicine being used for the treatment of menoxenia.
Above-mentioned Drymaria diandra Blume is the herb of Caryophyllaceae Drymaria diandra Blume platymiscium Drymaria diandra Blume Drymaria diandra Blume [D.cordata auct.non (L.) Willd.], Xia Qiucai, cleans using fresh herb or dries.Heat-clearing and toxic substances removing, diuresis relieving constipation, promoting blood circulation and detumescence, nebula removing.For acute hepatitis, stomachache, malaria, pterygium, ascites, constipation; Fracture is controlled in external, carbuncle sore, venom.The public blue or green Mus of duck is Li Ke hook fold plant Yunnan Radix Berchemiae Giraldianae BerchemiayunnanensisFranch., and the present invention is used as medicine with root, leaf.Qiu Caigen, Xia Caiye, dry.Clearing away heat-damp and promoting diuresis, dispelling, collateral-activating, promoting blood circulation and stopping pain.For jaundice, oedema due to nephritis, dysentery, redly collapses, leucorrhea, rheumatic ostalgia, dysmenorrhea; Fracture is controlled in external, traumatic injury, carbuncle sore tumefacting virus.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: Drymaria diandra Blume of the present invention, the public green grass or young crops of duck, Poria, Pericarpium Citri tangerinae, the Rhizoma Atractylodis Macrocephalae, Caulis Perillae clearing away heat-damp and promoting diuresis, blood-arresting catamenia-regulating are monarch drug, Rhizoma Coptidis, Fructus Hordei Germinatus, the Rhizoma Pinelliae, Poria cum Radix Pini, the Radix Astragali, Radix Codonopsis, Fructus Setariae Germinatus, Radix Saposhnikoviae, Flos Rosae Rugosae, Herba Ecliptae, Endothelium Corneum Gigeriae Galli blood circulation promoting and blood stasis dispelling are ministerial drug, Radix Glycyrrhizae is adjuvant, mediation pig medicine, full side's compatibility, blood-arresting catamenia-regulating, blood circulation promoting and blood stasis dispelling, treatment menoxenia successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Drymaria diandra Blume 12g, the public blue or green 10g of duck, Poria 10g, Pericarpium Citri tangerinae 6g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Perillae 10g, Rhizoma Coptidis 4g, Fructus Hordei Germinatus 40g, Rhizoma Pinelliae 10g, Poria cum Radix Pini 10g, Radix Astragali 20g, Radix Codonopsis 20g, Fructus Setariae Germinatus 10g, Radix Saposhnikoviae 10g, Flos Rosae Rugosae 10g, Herba Ecliptae 10g, Endothelium Corneum Gigeriae Galli 10g, Radix Glycyrrhizae 6g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Drymaria diandra Blume 12g, the public blue or green 10g of duck, Poria 10g, Pericarpium Citri tangerinae 6g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Perillae 10g, Rhizoma Coptidis 4g, Fructus Hordei Germinatus 40g, Rhizoma Pinelliae 10g, Poria cum Radix Pini 10g, Radix Astragali 20g, Radix Codonopsis 20g, Fructus Setariae Germinatus 10g, Radix Saposhnikoviae 10g, Flos Rosae Rugosae 10g, Herba Ecliptae 10g, Endothelium Corneum Gigeriae Galli 10g, Radix Glycyrrhizae 6g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Drymaria diandra Blume 12g, the public blue or green 10g of duck, Poria 10g, Pericarpium Citri tangerinae 6g, Rhizoma Atractylodis Macrocephalae 10g, Caulis Perillae 10g, Rhizoma Coptidis 4g, Fructus Hordei Germinatus 40g, Rhizoma Pinelliae 10g, Poria cum Radix Pini 10g, Radix Astragali 20g, Radix Codonopsis 20g, Fructus Setariae Germinatus 10g, Radix Saposhnikoviae 10g, Flos Rosae Rugosae 10g, Herba Ecliptae 10g, Endothelium Corneum Gigeriae Galli 10g, Radix Glycyrrhizae 6g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating menoxenia clinical research of the present invention
4.1 general data: this Chinese medicine composition is applied to clinical observation menoxenia case 50 example, 18 ~ 39 years old age.The shortest person of the course of disease 1 year, most elder reaches 2 years, average 1.5 years.
4.2 diagnostic criterias:
4.2.1 infrequent menstruation a: menstrual blood loss is less than 10 milliliters or few and all wets to two layers of paper not saturating, even if hypomenorrhea.
4.2.2 change in menstrual cycle: repeatedly change in menstrual cycle more than 7 days persons.
4.2.3 menorrhagia: be that in continuous several menstrual cycle, BTB amount is many, but menstruation interval time and bleeding time are all regular, without the unexpected increase of intermenstrual bleeding, postcoital bleeding or menses.There is the class in ovulation type dysfunctional uterine bleeding in system.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: clinical recovery: menstrual cycle recovers normal, and menstrual blood volume is normal, maintains more than 3 months.Take a turn for the better: menstrual cycle recovers normal, and menstrual blood volume is normal, but can not maintain more than 3 months.Invalid: menstrual cycle and menstrual blood volume have no improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 30 | 13 | 15 | 2 | 93.3 |
| Blank group | 20 | 0 | 1 | 19 | 5 |
Visible the present invention has good therapeutic effect to menoxenia, and toxic and side effects does not occur treatments period.
4.6 model cases:
Field, female, 24 years old, menstrual cycle was 50 days, continuous 2 months, gynecologial examination B ultrasonic, got rid of uterus and ovary organic disease, and amount is few, and color is dim clot, cold and pain in the lower abdomen, obtains hot alleviating, aversion to cold and cold limbs.Take above-mentioned process for producing granula and prepare clinical sample, specification is 10 grams every bag, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.After 2 months, menstrual cycle recovers normal, and menstrual blood volume is normal, and maintains 1 year.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of menoxenia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Drymaria diandra Blume 12 parts, public blue or green 10 parts of duck, 10 parts, Poria, Pericarpium Citri tangerinae 6 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Caulis Perillae 10 parts, Rhizoma Coptidis 4 parts, 40 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 10 parts, Poria cum Radix Pini 10 parts, the Radix Astragali 20 parts, Radix Codonopsis 20 parts, Fructus Setariae Germinatus 10 parts, Radix Saposhnikoviae 10 parts, Flos Rosae Rugosae 10 parts, Herba Ecliptae 10 parts, Endothelium Corneum Gigeriae Galli 10 parts, 6 parts, Radix Glycyrrhizae.
2. be used for the treatment of the Chinese medicine composition of menoxenia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of menoxenia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in treatment menoxenia medicine of menoxenia according to claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056156A (en) * | 2015-09-21 | 2015-11-18 | 南京正亮医药科技有限公司 | Medicine preparation for treating pulmonary artery embolism |
| CN108992616A (en) * | 2018-10-19 | 2018-12-14 | 魏尹书 | A kind of Chinese medicine preparation and preparation method thereof for treating gynaecological disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485803A (en) * | 2009-02-24 | 2009-07-22 | 西安天一制药有限责任公司 | Chinese medicinal composition for treating menoxenia and dysmenorrhea |
| CN102018758A (en) * | 2007-12-28 | 2011-04-20 | 上海中药制药技术有限公司 | Traditional Chinese medicinal composition for preventing and treating abnormal menstruation and preparation method thereof |
-
2015
- 2015-04-28 CN CN201510208086.1A patent/CN104800681A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018758A (en) * | 2007-12-28 | 2011-04-20 | 上海中药制药技术有限公司 | Traditional Chinese medicinal composition for preventing and treating abnormal menstruation and preparation method thereof |
| CN101485803A (en) * | 2009-02-24 | 2009-07-22 | 西安天一制药有限责任公司 | Chinese medicinal composition for treating menoxenia and dysmenorrhea |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056156A (en) * | 2015-09-21 | 2015-11-18 | 南京正亮医药科技有限公司 | Medicine preparation for treating pulmonary artery embolism |
| CN108992616A (en) * | 2018-10-19 | 2018-12-14 | 魏尹书 | A kind of Chinese medicine preparation and preparation method thereof for treating gynaecological disease |
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Application publication date: 20150729 |
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