CN105232712A - Pharmaceutical preparation for treating irregular menstruation - Google Patents
Pharmaceutical preparation for treating irregular menstruation Download PDFInfo
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- CN105232712A CN105232712A CN201510781511.6A CN201510781511A CN105232712A CN 105232712 A CN105232712 A CN 105232712A CN 201510781511 A CN201510781511 A CN 201510781511A CN 105232712 A CN105232712 A CN 105232712A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a pharmaceutical preparation for treating irregular menstruation. The pharmaceutical preparation is prepared from the following raw materials: 20 parts of bentham dichrocephala herbs, 25 parts of Japanese ardisia herbs, 22 parts of crotalaria mairei, 26 parts of biden bipinnata, 15 parts of peach kernels, 25 parts of angelica sinensis, 28 parts of cowherb seeds, 15 parts of radix angelicae, 15 parts of broadleaf holy leaves, 20 parts of safflowers, 25 parts of patrinia, 20 parts of caulis spatholobi, 25 parts of honeysuckles, 20 parts of red paeony roots, 15 parts of fructus evodiae and 5 parts of liquorice. The pharmaceutical preparation can be used for treating irregular menstruation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of menoxenia and its preparation method and application.
Background technology
Menoxenia is a kind of common gynecological disease, the change in menstrual cycle characteristics that general reference a variety of causes causes, show as the exception of menstrual cycle or amount of bleeding, or the moon is premenstrual, menstrual period time stomachache and General Symptoms, the traditional Chinese medical science is thought and is gone out all kidneys through water, points out that menopathy is relevant with renal function, also be correlated with spleen, liver, QI and blood, chong channel, conception vessel, uterus, this disease comprise age of menarche in advance, delay, cycle, menstrual period and the change through measuring, be one of modal symptom of gynaecological disease; Treating menoxenia disease in medicinal generally adopts Western medicine to be main, and Chinese patent medicine is auxiliary, although comprise the function that the medicine such as YUNNAN BAIYAO, GONGXUENING JIAONANG has hemostasis, blood circulation promoting and blood stasis dispelling, there is the defect of weak curative effect in clinical treatment; When adopting western medicine menoxenia disease, although curative effect is than Chinese patent medicine Be very effective, when patient takes, there is the problem that drug side effect is large, cost is high.For this reason, be bursting to and develop the needs that more medicines for the treatment of menoxenia safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of menoxenia disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of menoxenia, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Houttuyniae 20 parts, Herba Ardisiae Japonicae 25 parts, headdress flower Herba crotalariae mucronatae 22 parts, Herba bidentis parviflorae 26 parts, 15 parts, Semen Persicae, Radix Angelicae Sinensis 25 parts, Semen Vaccariae 28 parts, the Radix Angelicae Dahuricae 15 parts, Folium Ilicis 15 parts, 20 parts, Flos Carthami, Herba Patriniae 25 parts, Caulis Spatholobi 20 parts, Flos Lonicerae 25 parts, Radix Paeoniae Rubra 20 parts, Fructus Evodiae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of menoxenia, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of menoxenia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment menoxenia medicine being used for the treatment of menoxenia.
Herba Houttuyniae is Compositae Dichrocephala plant Herba Houttuyniae Dichrocephalaauriculata (Thunb.) Druce, with all herbal medicine.Promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.For menoxenia, sprain and swell and ache; Venom is controlled in external, furunculosis.
Herba Ardisiae Japonicae is the Herb of Myrsinacea plant Herba Ardisiae Japonicae Ardisiajaponica (Hornst.) B1..
Headdress flower Herba crotalariae mucronatae is pulse family Genus Crotalaria Linn headdress flower Herba crotalariae mucronatae CrotalariacapitataBenth., is used as medicine with root.Autumn adopts, and cleans and dries.Heat-clearing and toxic substances removing, antidiarrheal.For infantile pneumonia, infantile diarrhea, furuncle furuncle, traumatic injury, trauma infection contamination.
Herba bidentis parviflorae, formal name used at school BidensbipinnataL., Compositae, Herba bidentis parviflorae platymiscium, Herba bidentis parviflorae is born in hillside, meadow or roadside more.Be widely distributed in all parts of the country.Wanda Mountain district quantity is more.With all herbal medicine.Gather during summer-flowering, cutting, dries.Heat-clearing and toxic substances removing, expelling wind and activating blood circulation.For upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis, acute icteric infectious hepatitis, gastroenteritis, dyspepsia, rheumatic arthritis, malaria; Furuncle is controlled in external, venom, treating swelling and pain by traumatic injury.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science think menoxenia basic blood deficiency, suffer from a deficiency of the kidney, cold in blood, endocrine disturbance, Herba Houttuyniae of the present invention, Herba Ardisiae Japonicae, headdress flower Herba crotalariae mucronatae, Herba bidentis parviflorae, Semen Persicae, Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling are monarch drug, Semen Vaccariae, the Radix Angelicae Dahuricae, Folium Ilicis, Flos Carthami, Herba Patriniae, Caulis Spatholobi, Flos Lonicerae, Radix Paeoniae Rubra, Fructus Evodiae supplementing QI and nourishing YIN, promoting the circulation of QI to relieve pain are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, treatment menoxenia successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Houttuyniae 20g, Herba Ardisiae Japonicae 25g, headdress flower Herba crotalariae mucronatae 22g, Herba bidentis parviflorae 26g, Semen Persicae 15g, Radix Angelicae Sinensis 25g, Semen Vaccariae 28g, Radix Angelicae Dahuricae 15g, Folium Ilicis 15g, Flos Carthami 20g, Herba Patriniae 25g, Caulis Spatholobi 20g, Flos Lonicerae 25g, Radix Paeoniae Rubra 20g, Fructus Evodiae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Houttuyniae 20g, Herba Ardisiae Japonicae 25g, headdress flower Herba crotalariae mucronatae 22g, Herba bidentis parviflorae 26g, Semen Persicae 15g, Radix Angelicae Sinensis 25g, Semen Vaccariae 28g, Radix Angelicae Dahuricae 15g, Folium Ilicis 15g, Flos Carthami 20g, Herba Patriniae 25g, Caulis Spatholobi 20g, Flos Lonicerae 25g, Radix Paeoniae Rubra 20g, Fructus Evodiae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Houttuyniae 20g, Herba Ardisiae Japonicae 25g, headdress flower Herba crotalariae mucronatae 22g, Herba bidentis parviflorae 26g, Semen Persicae 15g, Radix Angelicae Sinensis 25g, Semen Vaccariae 28g, Radix Angelicae Dahuricae 15g, Folium Ilicis 15g, Flos Carthami 20g, Herba Patriniae 25g, Caulis Spatholobi 20g, Flos Lonicerae 25g, Radix Paeoniae Rubra 20g, Fructus Evodiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating gynecological of the present invention menoxenia clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation gynecological menoxenia case 40 example, 16 ~ 35 years old age.The shortest person of the course of disease 4 months, most elder reaches 3 years, average 1.4 years.
4.2 diagnostic criterias:
4.2.1 infrequent menstruation a: menstrual blood loss is less than 10 milliliters or few and all wets to two layers of paper not saturating, even if hypomenorrhea.
4.2.2 change in menstrual cycle: repeatedly change in menstrual cycle more than 7 days persons.
4.2.3 menorrhagia: be that in continuous several menstrual cycle, BTB amount is many, but menstruation interval time and bleeding time are all regular, without the unexpected increase of intermenstrual bleeding, postcoital bleeding or menses.There is the class in ovulation type dysfunctional uterine bleeding in system.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: clinical recovery: menstrual cycle recovers normal, and menstrual blood volume is normal, maintains more than 3 months.Take a turn for the better: menstrual cycle recovers normal, and menstrual blood volume is normal, but can not maintain more than 3 months.Invalid: menstrual cycle and menstrual blood volume have no improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
Treatment group | 20 | 5 | 12 | 3 | 85 |
Blank group | 20 | 1 | 1 | 18 | 10 |
Visible the present invention has good therapeutic effect to gynecological's menoxenia, and toxic and side effects does not occur treatments period.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of menoxenia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Houttuyniae 20 parts, Herba Ardisiae Japonicae 25 parts, headdress flower Herba crotalariae mucronatae 22 parts, Herba bidentis parviflorae 26 parts, 15 parts, Semen Persicae, Radix Angelicae Sinensis 25 parts, Semen Vaccariae 28 parts, the Radix Angelicae Dahuricae 15 parts, Folium Ilicis 15 parts, 20 parts, Flos Carthami, Herba Patriniae 25 parts, Caulis Spatholobi 20 parts, Flos Lonicerae 25 parts, Radix Paeoniae Rubra 20 parts, Fructus Evodiae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of menoxenia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of menoxenia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment menoxenia medicine of menoxenia according to claim 1.
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CN107998191A (en) * | 2017-12-26 | 2018-05-08 | 佛山市赛普斯科技服务有限公司 | A kind of nourishing yin and supplementing blood prescription for treating menstrual disorder and preparation method thereof |
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Cited By (1)
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CN107998191A (en) * | 2017-12-26 | 2018-05-08 | 佛山市赛普斯科技服务有限公司 | A kind of nourishing yin and supplementing blood prescription for treating menstrual disorder and preparation method thereof |
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Application publication date: 20160113 |