CN104840759A - Medicine preparation used for treating dyspepsia - Google Patents
Medicine preparation used for treating dyspepsia Download PDFInfo
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- CN104840759A CN104840759A CN201510301039.1A CN201510301039A CN104840759A CN 104840759 A CN104840759 A CN 104840759A CN 201510301039 A CN201510301039 A CN 201510301039A CN 104840759 A CN104840759 A CN 104840759A
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Abstract
The invention belongs to the field of traditional Chinese medicines and provides a medicine preparation used for treating dyspepsia. The medicine preparation is prepared from the following raw materials: 20 parts of eria graminifolia, 18 parts of begonia pedatifida, 6 parts of radix bupleuri, 10 parts of nutgrass galingale rhizome, 10 parts of Chinese angelica, 10 parts of dried tangerine peel, 10 parts of tangerine seed, 12 parts of refuse of deerhorn glue, 10 parts of bitter orange, 10 parts of Indian buead, 12 parts of fruit of fiverleaf akebia, 10 parts of Himalayan teasel root, 15 parts of flower of silktree albizzia, 12 parts of white paeony root, 10 parts of largehead atractylodes rhizome, 15 parts of Mongolian dandelion herb, 12 parts of eucommia bark and 3 parts of liquorice root. The medicine preparation can be used for treating dyspepsia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of dyspeptic pharmaceutical preparation and its preparation method and application.
Background technology
Claim dyspepsia, refer to that there is the malaise symptoms such as upper abdominal pain, big belly, early full, belch, inappetence, Nausea and vomiting, get rid of the one group of clinical syndrome causing the organic disease of above-mentioned symptom on inspection.Sustainable or the recurrent exerbation of symptom, accumulative more than 12 weeks in course of disease December more than month or in the past, be modal a kind of functional gastrointestinal disorder clinically.For this reason, be bursting to develop and manyly treat the needs that dyspeptic medicine meets clinical treatment safely and effectively.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of dyspepsia disease.In order to reach this object, adopt following technical scheme:
Technical scheme: one is used for the treatment of dyspeptic pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Eria graminifolia Lindl. 20 parts, the palm split Flos Begoniae Evansianae 18 parts, Radix Bupleuri 6 parts, Rhizoma Cyperi 10 parts, Radix Angelicae Sinensis 10 parts, Pericarpium Citri Reticulatae 10 parts, Semen Citri Reticulatae 10 parts, Cornu Cervi Degelatinatum 12 parts, Fructus Aurantii 10 parts, 10 parts, Poria, Fructus Akebiae 12 parts, Radix Dipsaci 10 parts, Flos Albiziae 15 parts, the Radix Paeoniae Alba 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Taraxaci 15 parts, the Cortex Eucommiae 12 parts, 3 parts, Radix Glycyrrhizae.
Describedly be used for the treatment of dyspeptic pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.
Describedly be used for the treatment of dyspeptic pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
Describedly be used for the treatment of the application of dyspeptic pharmaceutical preparation in preparation treatment dyspepsia medicine.
Eria graminifolia Lindl. is the orchid family hair orchid platymiscium Eria graminifolia Lindl. Eria graminifolia Lindl., with all herbal medicine.7 ~ August gathers, and clean cutting is dried.Stomach reinforcing, promotes the production of body fluid.For consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, achlorhydria.It is that the Begoniaceae Begonia plant palm splits Flos Begoniae Evansianae Begonia pedatifida Levl. and is used as medicine with root stock that the palm splits Flos Begoniae Evansianae.Autumn and winter excavate, and clean section is dried.Dissipating blood stasis, hemostasia and detumescence, pain relieving.For spitting blood, metrorrhagia, stomachache, rheumatic arthritis; External is controlled traumatic injury and is swollen and ache, venom.All the other medical materials are pharmacopeia kind.
Beneficial effect: Herba passiflorae cochinchinensis of the present invention, Cortex cercis chinensis, Radix Rehmanniae, Rhizoma Coptidis, the Radix Paeoniae Alba, Radix Codonopsis, the Radix Astragali, Poria cum Radix Pini, Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori, Concha Margaritifera, Fructus Trichosanthis, pockmarks core heat-clearing and toxic substances removing, tranquillizing and allaying excitement, invigorating the spleen and replenishing QI, treatment dyspepsia successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Eria graminifolia Lindl. 20g, the palm splits Flos Begoniae Evansianae 18g, Radix Bupleuri 6g, Rhizoma Cyperi 10g, Radix Angelicae Sinensis 10g, Pericarpium Citri Reticulatae 10g, Semen Citri Reticulatae 10g, Cornu Cervi Degelatinatum 12g, Fructus Aurantii 10g, Poria 10g, Fructus Akebiae 12g, Radix Dipsaci 10g, Flos Albiziae 15g, Radix Paeoniae Alba 12g, Rhizoma Atractylodis Macrocephalae 10g, Herba Taraxaci 15g, Cortex Eucommiae 12g, Radix Glycyrrhizae 3g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Eria graminifolia Lindl. 20g, the palm splits Flos Begoniae Evansianae 18g, Radix Bupleuri 6g, Rhizoma Cyperi 10g, Radix Angelicae Sinensis 10g, Pericarpium Citri Reticulatae 10g, Semen Citri Reticulatae 10g, Cornu Cervi Degelatinatum 12g, Fructus Aurantii 10g, Poria 10g, Fructus Akebiae 12g, Radix Dipsaci 10g, Flos Albiziae 15g, Radix Paeoniae Alba 12g, Rhizoma Atractylodis Macrocephalae 10g, Herba Taraxaci 15g, Cortex Eucommiae 12g, Radix Glycyrrhizae 3g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Eria graminifolia Lindl. 20g, the palm splits Flos Begoniae Evansianae 18g, Radix Bupleuri 6g, Rhizoma Cyperi 10g, Radix Angelicae Sinensis 10g, Pericarpium Citri Reticulatae 10g, Semen Citri Reticulatae 10g, Cornu Cervi Degelatinatum 12g, Fructus Aurantii 10g, Poria 10g, Fructus Akebiae 12g, Radix Dipsaci 10g, Flos Albiziae 15g, Radix Paeoniae Alba 12g, Rhizoma Atractylodis Macrocephalae 10g, Herba Taraxaci 15g, Cortex Eucommiae 12g, Radix Glycyrrhizae 3g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment dyspepsia of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation dyspepsia case 60 example, wherein man 28 example, female 32 example, 23 ~ 55 years old age.The shortest person of the course of disease 1 year, most elder reaches 3 years, average 1.7 years.
4.2 diagnostic criterias: 1) there is in past 1 year at least 4 weeks the symptom such as upper abdominal pain or discomfort (big belly, early full, flatulence, nauseating, belch).2) the organic disease person of peptic ulcer, chronic (erosive or atrophic) gastritis, gastric tumor regulating liver-QI pancreaticobiliary disease etc. and soluble above-mentioned symptom is got rid of.3) get rid of with the abnormal irritable bowel syndrome person for primary symptom of stomachache, times of defecation and character.
4.3 test method: be divided into 2 groups at random, often organize 30 people, i.e. the blank group of therapeutic combination, prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) clinical recovery: symptom, sign disappear or improve more than 3 grades, abnormal index recovers normally substantially, maintenance is no longer recurred for more than 2 months; Effective: symptom, sign reduce or improve more than 2 grades, and abnormal index obviously improves; Take a turn for the better: symptom, sign alleviate or improve more than 1 grade, abnormal index takes a turn for the better.Invalid: symptom, sign and abnormal index are all without improvement.。
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 30 | 7 | 13 | 7 | 3 | 90 |
| Blank group | 30 | 0 | 2 | 1 | 27 | 10 |
Visible, the medicine that the present invention obtains can safe and effective treatment dyspepsia, has no side effect in use procedure.
Claims (4)
1. be used for the treatment of a dyspeptic pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Eria graminifolia Lindl. 20 parts, the palm split Flos Begoniae Evansianae 18 parts, Radix Bupleuri 6 parts, Rhizoma Cyperi 10 parts, Radix Angelicae Sinensis 10 parts, Pericarpium Citri Reticulatae 10 parts, Semen Citri Reticulatae 10 parts, Cornu Cervi Degelatinatum 12 parts, Fructus Aurantii 10 parts, 10 parts, Poria, Fructus Akebiae 12 parts, Radix Dipsaci 10 parts, Flos Albiziae 15 parts, the Radix Paeoniae Alba 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Taraxaci 15 parts, the Cortex Eucommiae 12 parts, 3 parts, Radix Glycyrrhizae.
2. be used for the treatment of dyspeptic pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of dyspeptic pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of dyspeptic pharmaceutical preparation in treatment dyspepsia medicine according to claim 1.
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| CN201510301039.1A CN104840759A (en) | 2015-06-05 | 2015-06-05 | Medicine preparation used for treating dyspepsia |
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| CN201510301039.1A CN104840759A (en) | 2015-06-05 | 2015-06-05 | Medicine preparation used for treating dyspepsia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031497A (en) * | 2015-08-26 | 2015-11-11 | 南京正宽医药科技有限公司 | Medicinal preparation for treating chronic gastritis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626119A (en) * | 2003-12-08 | 2005-06-15 | 马斌 | Chinese traditional medicine for treating functional dyspepsia |
| CN103599434A (en) * | 2013-11-25 | 2014-02-26 | 禤燕华 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
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2015
- 2015-06-05 CN CN201510301039.1A patent/CN104840759A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626119A (en) * | 2003-12-08 | 2005-06-15 | 马斌 | Chinese traditional medicine for treating functional dyspepsia |
| CN103599434A (en) * | 2013-11-25 | 2014-02-26 | 禤燕华 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031497A (en) * | 2015-08-26 | 2015-11-11 | 南京正宽医药科技有限公司 | Medicinal preparation for treating chronic gastritis |
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Application publication date: 20150819 |