CN105055702A - Pharmaceutical preparation for treating chronic pelvic inflammatory disease - Google Patents
Pharmaceutical preparation for treating chronic pelvic inflammatory disease Download PDFInfo
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- CN105055702A CN105055702A CN201510564180.0A CN201510564180A CN105055702A CN 105055702 A CN105055702 A CN 105055702A CN 201510564180 A CN201510564180 A CN 201510564180A CN 105055702 A CN105055702 A CN 105055702A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a pharmaceutical preparation for treating chronic pelvic inflammatory disease, which is prepared from the following raw materials: 25 parts of fomes officinalis ames, 18 parts of heteropanax fragrans, 20 parts of achyranthes bidentata, 18 parts of eucheuma, 25 parts of coptis root, 15 parts of panicled swallowwort root, 20 parts of Chinese pulsatilla, 20 parts of sargentgloryvine stem, 25 parts of cnidium fruit, 25 parts of pipewort, 20 parts of chrysanthemum, 15 parts of dandelion, 18 parts of corydalis tuber, 15 parts of baikal skullcap root, 20 parts of motherwort, 15 parts of bighead atractylodes rhizome and 5 parts of licorice. The pharmaceutical preparation provided by the invention can be used for treating chronic pelvic inflammatory disease.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease and its preparation method and application.
Background technology
Pelvic inflammatory disease refers to female pelvic cavity genitals, periuterine connective tissue and pelvic peritoneal inflammation.Chronic pelvic inflammatory disease often acute stages treated is not thoroughly delayed, and because its disease time is long, the state of an illness is more obstinate, and the antibacterial of external genital can retrograde infection, by uterus, fallopian tube and arrive pelvic cavity.But in actual life, not all women can suffer from pelvic inflammatory disease, morbidity is minority just.This is because female reproductive system has natural defense function, under normal circumstances, the invasion of antibacterial can be resisted, only have the resistance when body to decline, or due to other reasons the natural defense function of women is destroyed time, just can cause the generation of pelvic inflammatory disease.Patients with Pelvic Inflammatory Disease susceptible is tired.The cicatricial adhesion that chronic inflammatory disease is formed and pelvic congestion, can cause hypogastric region falling inflation, pain and lumbosacral region to ache, aggravate before and after fatigue of being everlasting, sexual intercourse, menstruation.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic pelvic inflammatory disease safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic pelvic inflammatory disease disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Fructificatio Fomitopsis Officinalis 25 parts, 18 parts, heavy curtain umbrella maple, Radix Anemones rivularis 20 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 18 parts, Rhizoma Coptidis 25 parts, Radix Cynanchi Paniculati 15 parts, the Radix Pulsatillae 20 parts, Caulis Sargentodoxae 20 parts, Fructus Cnidii 25 parts, Flos Eriocauli 25 parts, Flos Chrysanthemi 20 parts, Herba Taraxaci 15 parts, Rhizoma Corydalis 18 parts, Radix Scutellariae 15 parts, Herba Leonuri 20 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic pelvic inflammatory disease, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic pelvic inflammatory disease medicine being used for the treatment of chronic pelvic inflammatory disease.
Fructificatio Fomitopsis Officinalis, the cap shape of a hoof, usual fist is greatly or larger, white to faint yellow, the thin skin that initial stage surface tool is smooth, after gradually ftracture roughening, sometimes have concentric endless belt, edge is blunt; Bacterial context is soft, white powder, loose light weight, frangible time old; Tube white, multilamellar.Spore is colourless, smooth, avette, and Classification system is Fomesofficinalis (Vill.EtFr.) Ames, has warming the lung for resolving phlegm, lowering the adverse-rising QI to subdue asthma, expelling wind and removing dampness, promoting blood circulation and detumescence, diuresis, the effect of antidoting against snake bite.For cough, asthma, stomachache, hyperchlorhydria, lithangiuria, nephritis, chronic rheumatic arthritis, pharyngolaryngitis, periodontitis, venom.
Heavy curtain umbrella maple is Araliaceae, Heteropanax aiphyllium, and Classification system Heteropanaxfragrans (Roxb.) Seem., is used as medicine with root, energy heat-clearing and toxic substances removing, promoting blood circulation and detumescence, pain relieving.For flu, heatstroke is had a headache; Carbuncle furuncle and phyma poison is controlled in external, lymphadenitis, fracture, burn and scald, bruise, venom.
Radix Anemones rivularis is root or the herb of ranunculaceae plant little Hua Herba Veronicastri Sibirici.Invigorating the stomach and promoting digestion, dissipating blood stasis disappears knot.For hepatitis, carbuncle of yin nature, carbuncle is had a pain.
Eucheuma muricatum (Gmel.) Web.Van Bos. is the frond of Hong Ling dish section plant Eucheuma muricatum (Gmel.) Web.Van Bos. or Margarita Eucheuma muricatum (Gmel.) Web.Van Bos..Expectorant.Can be reduced phlegm knot, mass in the abdomen, hemorrhoid poison.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: pelvic inflammatory disease belongs to the category of " leukorrhagia " in Chinese medicine, " dysmenorrhea ", " note of the ancient Chinese abdominal mass ".The traditional Chinese medical science is thought, this disease many because of natural endowment not enough, maintenance is at ordinary times careless, caused by the unclean or overstrain of vaginal orifice.Fructificatio Fomitopsis Officinalis of the present invention, heavy curtain umbrella maple, Radix Anemones rivularis, Eucheuma muricatum (Gmel.) Web.Van Bos., Rhizoma Coptidis, Radix Cynanchi Paniculati, the Radix Pulsatillae, Caulis Sargentodoxae heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling are monarch drug, Fructus Cnidii, Flos Eriocauli, Flos Chrysanthemi, Herba Taraxaci, Rhizoma Corydalis, Radix Scutellariae, Herba Leonuri, Rhizoma Atractylodis Macrocephalae killing parasites for relieving itching, dispeiling pathogenic wind and removing dampness are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, killing parasites for relieving itching, dispeiling pathogenic wind and removing dampness, treatment chronic pelvic inflammatory disease successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Fructificatio Fomitopsis Officinalis 25g, heavy curtain umbrella maple 18g, Radix Anemones rivularis 20g, Eucheuma muricatum (Gmel.) Web.Van Bos. 18g, Rhizoma Coptidis 25g, Radix Cynanchi Paniculati 15g, Radix Pulsatillae 20g, Caulis Sargentodoxae 20g, Fructus Cnidii 25g, Flos Eriocauli 25g, Flos Chrysanthemi 20g, Herba Taraxaci 15g, Rhizoma Corydalis 18g, Radix Scutellariae 15g, Herba Leonuri 20g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Fructificatio Fomitopsis Officinalis 25g, heavy curtain umbrella maple 18g, Radix Anemones rivularis 20g, Eucheuma muricatum (Gmel.) Web.Van Bos. 18g, Rhizoma Coptidis 25g, Radix Cynanchi Paniculati 15g, Radix Pulsatillae 20g, Caulis Sargentodoxae 20g, Fructus Cnidii 25g, Flos Eriocauli 25g, Flos Chrysanthemi 20g, Herba Taraxaci 15g, Rhizoma Corydalis 18g, Radix Scutellariae 15g, Herba Leonuri 20g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Fructificatio Fomitopsis Officinalis 25g, heavy curtain umbrella maple 18g, Radix Anemones rivularis 20g, Eucheuma muricatum (Gmel.) Web.Van Bos. 18g, Rhizoma Coptidis 25g, Radix Cynanchi Paniculati 15g, Radix Pulsatillae 20g, Caulis Sargentodoxae 20g, Fructus Cnidii 25g, Flos Eriocauli 25g, Flos Chrysanthemi 20g, Herba Taraxaci 15g, Rhizoma Corydalis 18g, Radix Scutellariae 15g, Herba Leonuri 20g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment chronic pelvic inflammatory disease of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic pelvic inflammatory disease case 60 example, 27 ~ 42 years old age.The shortest person of the course of disease 4 months, most elder reaches 3 years.
4.2 diagnostic criterias: all cases all meet the diagnostic criteria of " leukorrhagia " in " the Chinese medical disease diagnostic criteria " that State Administration of Traditional Chinese Medicine issues.All doctor trained in Western medicine chronic pelvic inflammatory diseases that meets diagnose or accompany pelvic lump person all can include in.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: cure: patients symptomatic and sign all disappear; Effective: patient's major part sings and symptoms disappears, and the display of gynecologial examination result improves obviously, B ultrasonic prompting inflammatory mass obviously reduces; Effective: patients symptomatic, sign are all improved, B ultrasonic prompting inflammatory mass reduces, and Mass volum reduces the scope and is less than 2/3rds on time; Invalid: patients symptomatic is without improvement, and the check result display state of an illness is unchanged or get along with.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 5 | 12 | 9 | 4 | 86.7 |
| Blank group | 30 | 1 | 1 | 2 | 26 | 13.3 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic pelvic inflammatory disease, and has no side effect.
4.6 Zhao, female, 35 years old, suffers from chronic pelvic inflammatory disease 2 years, shows as menoxenia, leucorrhoea grow in quantity, waist abdomen pain.Give the Chinese medicine that granule embodiment of the present invention provides, after 2 courses for the treatment of, patients symptomatic and sign all disappear.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic pelvic inflammatory disease, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Fructificatio Fomitopsis Officinalis 25 parts, 18 parts, heavy curtain umbrella maple, Radix Anemones rivularis 20 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 18 parts, Rhizoma Coptidis 25 parts, Radix Cynanchi Paniculati 15 parts, the Radix Pulsatillae 20 parts, Caulis Sargentodoxae 20 parts, Fructus Cnidii 25 parts, Flos Eriocauli 25 parts, Flos Chrysanthemi 20 parts, Herba Taraxaci 15 parts, Rhizoma Corydalis 18 parts, Radix Scutellariae 15 parts, Herba Leonuri 20 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic pelvic inflammatory disease as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic pelvic inflammatory disease as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic pelvic inflammatory disease medicine of chronic pelvic inflammatory disease according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510564180.0A CN105055702A (en) | 2015-09-07 | 2015-09-07 | Pharmaceutical preparation for treating chronic pelvic inflammatory disease |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510564180.0A CN105055702A (en) | 2015-09-07 | 2015-09-07 | Pharmaceutical preparation for treating chronic pelvic inflammatory disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288506A (en) * | 2015-12-03 | 2016-02-03 | 苏州枫灵医药科技有限公司 | Pharmaceutical preparation for treating acute pelvic inflammatory disease |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589866A (en) * | 2003-08-28 | 2005-03-09 | 深圳波斯迪药业有限公司 | External use Chinese medicinal preparation for treating gynecopathy and its manufacturing method |
| CN1634364A (en) * | 2004-11-22 | 2005-07-06 | 苟文丽 | Enema for treating pelvic inflammation and other disease |
| CN104800505A (en) * | 2015-04-24 | 2015-07-29 | 臧孝国 | Traditional Chinese medicine composition for treating irregular menstruation |
| CN104815092A (en) * | 2015-05-05 | 2015-08-05 | 许玉刚 | Traditional Chinese medicine composition for treating chronic pelvic inflammation |
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2015
- 2015-09-07 CN CN201510564180.0A patent/CN105055702A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589866A (en) * | 2003-08-28 | 2005-03-09 | 深圳波斯迪药业有限公司 | External use Chinese medicinal preparation for treating gynecopathy and its manufacturing method |
| CN1634364A (en) * | 2004-11-22 | 2005-07-06 | 苟文丽 | Enema for treating pelvic inflammation and other disease |
| CN104800505A (en) * | 2015-04-24 | 2015-07-29 | 臧孝国 | Traditional Chinese medicine composition for treating irregular menstruation |
| CN104815092A (en) * | 2015-05-05 | 2015-08-05 | 许玉刚 | Traditional Chinese medicine composition for treating chronic pelvic inflammation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288506A (en) * | 2015-12-03 | 2016-02-03 | 苏州枫灵医药科技有限公司 | Pharmaceutical preparation for treating acute pelvic inflammatory disease |
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Application publication date: 20151118 |
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