CN104800505A

CN104800505A - Traditional Chinese medicine composition for treating irregular menstruation

Info

Publication number: CN104800505A
Application number: CN201510204205.6A
Authority: CN
Inventors: 臧孝国
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-24
Filing date: 2015-04-24
Publication date: 2015-07-29

Abstract

The invention provides a traditional Chinese medicine composition for treating irregular menstruation. The traditional Chinese medicine composition is prepared from the following raw materials: cardiocrinum giganteum, hyptis suaveolens, cyperus rotundus and the like. The invention also discloses a preparation method of the traditional Chinese medicine composition, and the traditional Chinese medicine composition can be used for treating irregular menstruation.

Description

A kind of Chinese medicine composition being used for the treatment of menoxenia

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of menoxenia and its preparation method and application.

Background technology

Menoxenia Xi Shi gynecological common disease, shows as the exception of menstrual cycle or amount of bleeding, can accompany that the moon is premenstrual, menstrual period time stomachache and General Symptoms.The cause of disease may be organic disease or malfunction.For this reason, be bursting to and develop the needs that more medicines for the treatment of menoxenia safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of menoxenia disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of Chinese medicine composition being used for the treatment of menoxenia, the active component contained by it is extracted by following weight crude drug and is prepared from: lobus cardiacus Bulbus Lilii 12 parts, Caulis et Folium Hyptidis suaveolentis 10 parts, Radix Rehmanniae 15 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Cyperi 10 parts, Fructus Lycii 12 parts, Fructus Ligustri Lucidi 15 parts, Radix Morindae Officinalis 9 parts, Semen Cuscutae 12 parts, Semen Astragali Complanati 10 parts, Fructus Psoraleae 10 parts, the Radix Aucklandiae 5 parts, Ramulus Cinnamomi 6 parts, Herba Cynomorii 8 parts, Fructus Corni 8 parts.

The described Chinese medicine composition being used for the treatment of menoxenia, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described Chinese medicine composition being used for the treatment of menoxenia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of Chinese medicine composition in preparation treatment menoxenia medicine being used for the treatment of menoxenia.

Above-mentioned lobus cardiacus Bulbus Lilii, Classification system Cardiocrinum giganteum (Wall.) Makino, is plant cardiocrinum giganteumMakino, is used as medicine with bulb.Summer excavates, and cleans and dries.Clearing away lung-heat to relieve cough, removing toxic substances.For hemoptysis of pulmonary tuberculosis, sinusitis, otitis media.Caulis et Folium Hyptidis suaveolentis is Labiatae Caulis et Folium Hyptidis suaveolentis platymiscium Caulis et Folium Hyptidis suaveolentis Hyptis suaveolens (L.) Poir., with all herbal medicine.Xia Qiu gathers, and dries in the shade or using fresh herb.Dispelling wind dampness removing, circulation of qi promoting dissipating blood stasis.For headache due to common cold, gastroenteritis, dysentery, abdominal distention; Treating swelling and pain by traumatic injury is controlled in external, wound hemorrhage, carbuncle sore tumefacting virus, worm venom, eczema, dermatitis.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: lobus cardiacus Bulbus Lilii of the present invention, Caulis et Folium Hyptidis suaveolentis, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Cyperi clearing away heat-damp and promoting diuresis, regulating menstruation are monarch drug, Fructus Lycii, Fructus Ligustri Lucidi, Radix Morindae Officinalis, Semen Cuscutae, Semen Astragali Complanati, Fructus Psoraleae, the Radix Aucklandiae, Ramulus Cinnamomi, Herba Cynomorii promoting the circulation of QI to relieve pain are ministerial drug, Fructus Corni is adjuvant, mediation pig medicine, full side's compatibility, clearing away heat-damp and promoting diuresis, regulating menstruation, blood circulation promoting and blood stasis dispelling, treatment menoxenia successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: core leaf Bulbus Lilii 12g, Caulis et Folium Hyptidis suaveolentis 10g, Radix Rehmanniae 15g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 15g, Rhizoma Cyperi 10g, Fructus Lycii 12g, Fructus Ligustri Lucidi 15g, Radix Morindae Officinalis 9g, Semen Cuscutae 12g, Semen Astragali Complanati 10g, Fructus Psoraleae 10g, Radix Aucklandiae 5g, Ramulus Cinnamomi 6g, Herba Cynomorii 8g, Fructus Corni 8g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: core leaf Bulbus Lilii 12g, Caulis et Folium Hyptidis suaveolentis 10g, Radix Rehmanniae 15g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 15g, Rhizoma Cyperi 10g, Fructus Lycii 12g, Fructus Ligustri Lucidi 15g, Radix Morindae Officinalis 9g, Semen Cuscutae 12g, Semen Astragali Complanati 10g, Fructus Psoraleae 10g, Radix Aucklandiae 5g, Ramulus Cinnamomi 6g, Herba Cynomorii 8g, Fructus Corni 8g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.

3, the preparation of capsule embodiment: core leaf Bulbus Lilii 12g, Caulis et Folium Hyptidis suaveolentis 10g, Radix Rehmanniae 15g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 15g, Rhizoma Cyperi 10g, Fructus Lycii 12g, Fructus Ligustri Lucidi 15g, Radix Morindae Officinalis 9g, Semen Cuscutae 12g, Semen Astragali Complanati 10g, Fructus Psoraleae 10g, Radix Aucklandiae 5g, Ramulus Cinnamomi 6g, Herba Cynomorii 8g, Fructus Corni 8g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.

4, traditional Chinese medicine composition for treating menoxenia clinical research of the present invention

4.1 general data: this Chinese medicine composition is applied to clinical observation menoxenia 80 cases, 18 ~ 39 years old age.The shortest person of the course of disease 3 months, most elder reaches 2 years, average 1.2 years.

4.2 diagnostic criterias:

4.2.1 infrequent menstruation a: menstrual blood loss is less than 10 milliliters or few and all wets to two layers of paper not saturating, even if hypomenorrhea.

4.2.2 change in menstrual cycle: repeatedly change in menstrual cycle more than 7 days persons.

4.2.3 menorrhagia: be that in continuous several menstrual cycle, BTB amount is many, but menstruation interval time and bleeding time are all regular, without the unexpected increase of intermenstrual bleeding, postcoital bleeding or menses.There is the class in ovulation type dysfunctional uterine bleeding in system.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: clinical recovery: menstrual cycle recovers normal, and menstrual blood volume is normal, maintains more than 3 months.Take a turn for the better: menstrual cycle recovers normal, and menstrual blood volume is normal, but can not maintain more than 3 months.Invalid: menstrual cycle and menstrual blood volume have no improvement.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	40	21	15	4	90
Blank group	40	1	3	36	10

Visible the present invention has good therapeutic effect to menoxenia, and toxic and side effects does not occur treatments period.

4.6 model cases:

Zhang, female, 24 years old, menstrual cycle was 60 days, continuous 5 months, gynecologial examination B ultrasonic, got rid of uterus and ovary organic disease, and amount is few, and color is dim clot, cold and pain in the lower abdomen, obtains hot alleviating, aversion to cold and cold limbs.Take above-mentioned process for producing granula and prepare clinical sample, specification is 10 grams every bag, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.After 3 months, menstrual cycle recovers normal, and menstrual blood volume is normal, and maintains 1 year.

Claims

1. one kind is used for the treatment of the Chinese medicine composition of menoxenia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: lobus cardiacus Bulbus Lilii 12 parts, Caulis et Folium Hyptidis suaveolentis 10 parts, Radix Rehmanniae 15 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Cyperi 10 parts, Fructus Lycii 12 parts, Fructus Ligustri Lucidi 15 parts, Radix Morindae Officinalis 9 parts, Semen Cuscutae 12 parts, Semen Astragali Complanati 10 parts, Fructus Psoraleae 10 parts, the Radix Aucklandiae 5 parts, Ramulus Cinnamomi 6 parts, Herba Cynomorii 8 parts, Fructus Corni 8 parts.

2. be used for the treatment of the Chinese medicine composition of menoxenia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the Chinese medicine composition of menoxenia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of Chinese medicine composition in treatment menoxenia medicine of menoxenia according to claim 1.