CN105126034A - Pharmaceutical preparation for treating coronary heart disease - Google Patents
Pharmaceutical preparation for treating coronary heart disease Download PDFInfo
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- CN105126034A CN105126034A CN201510645416.3A CN201510645416A CN105126034A CN 105126034 A CN105126034 A CN 105126034A CN 201510645416 A CN201510645416 A CN 201510645416A CN 105126034 A CN105126034 A CN 105126034A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a pharmaceutical preparation for treating a coronary heart disease. The pharmaceutical preparation is prepared from 20 parts of sedum sarmentosum, 25 parts of wingedstem inula roots, 22 parts of caragana rosea, 26 parts of bulbiferous stonecrop, 18 parts of angelica sinensis, 20 parts of ligusticum wallichii, 25 parts of corydalis tubers, 25 parts of allium macrostemon, 20 parts of curcuma aromatica, 20 parts of gastrodia elata, 20 parts of gynostemma pentaphylla, 25 parts of acanthopanax roots, 20 parts of salvia miltiorrhiza, 15 parts of cordate houttuynia, 15 parts of blackberrykiky rhizome and 5 parts of liquorice. The pharmaceutical preparation can treat the coronary heart disease.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of coronary heart disease and its preparation method and application.
Background technology
Coronary heart disease is coronary artery generation atherosclerotic lesion and causes lumen of vessels stenosis or occlusion, causes myocardial ischemia, anoxia or downright bad and heart disease that is that cause, is usually called as " coronary heart disease ".But the scope of coronary heart disease may be more extensive, also comprises inflammation, thromboembolism etc. and cause luminal stenosis or obturation.Coronary heart disease is divided into 5 large classes by World Health Organization (WHO): silent ischemia (latent coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic heart desease) and sudden death 5 kinds of Clinical types.Stable coronary heart disease and acute coronary syndrome is usually divided in clinical.For this reason, be bursting to and develop the needs that more medicines for the treatment of coronary heart disease safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of coronary heart disease disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of coronary heart disease, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: careless Mus tooth half 20 parts, Radix Inulae Pterocaulae 25 parts, Radix Caraganae Roseae 22 parts, Herba Sedi Bulbiferi 26 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 20 parts, Rhizoma Corydalis 25 parts, Bulbus Allii Macrostemonis 25 parts, Radix Curcumae 20 parts, 20 parts, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli 20 parts, Radix Et Caulis Acanthopanacis Senticosi 25 parts, Radix Salviae Miltiorrhizae 20 parts, Herba Houttuyniae 15 parts, Rhizoma Belamcandae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of coronary heart disease, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of coronary heart disease, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment medicaments for coronary disease being used for the treatment of coronary heart disease.
Grass Mus tooth half is the herb of Crassulaceae sengreen Herba Stellariae Alsines SedumlineareThunb..The four seasons can adopt, and clean, using fresh herb or dry.This Fructus Adinae is Rosaceae avens geum aleppicum GeumaleppicumJacq., with all herbal medicine.
Radix Inulae Pterocaulae is the root of feverfew wing stem Flos Inulae.Tonify deficiency, heat-clearing and toxic substances removing.
Radix Caraganae Roseae is the root of leguminous plant Radix Caraganae Roseae.Spleen invigorating, kidney tonifying, stimulates the menstrual flow, diuresis, treats deficient consumptive fever, cough, stranguria with turbid discharge, sexual impotence, metrorrhagia, leucorrhea, and breast is few, uterine prolapse.
Herba Sedi Bulbiferi is the herb of crassulaceae plants Sedumviviparum.Cold expelling, regulates the flow of vital energy, pain relieving, detumescence, hemostasis, preventing the attack (or recurrence) of malaria.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: coronary heart disease is attributed to the thoracic obstruction, cardiopalmus category by the traditional Chinese medical science.Motherland's medical science is thought, " over 40 gas cloudy from half ", people above middle age, due to the physiological change of body itself and life, work tire out, make it vigour to a certain extent impaired.So for dialectical total genus deficiency in origin and excess in superficiality of this disease, deficiency in origin is common the deficiency of vital energy, the deficiency of YIN, yang deficiency, blood deficiency, mark is real sees cold coagulation, stagnation of phlegm, blood stasis.The present invention's grass Mus tooth half, Radix Inulae Pterocaulae, Radix Caraganae Roseae, Herba Sedi Bulbiferi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis heat-clearing and toxic substances removing, Qi-benefiting and heart-nourishing are monarch drug, Bulbus Allii Macrostemonis, Radix Curcumae, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli, Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Herba Houttuyniae, Rhizoma Belamcandae the chest stuffiness relieving is regulated the flow of vital energy, removing obstruction in the collateral to relieve pain is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment coronary heart disease successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, the preparation of granule embodiment: get careless Mus tooth half 20g, Radix Inulae Pterocaulae 25g, Radix Caraganae Roseae 22g, Herba Sedi Bulbiferi 26g, Radix Angelicae Sinensis 18g, Rhizoma Chuanxiong 20g, Rhizoma Corydalis 25g, Bulbus Allii Macrostemonis 25g, Radix Curcumae 20g, Rhizoma Gastrodiae 20g, Herb Gynostemmae Pentaphylli 20g, Radix Et Caulis Acanthopanacis Senticosi 25g, Radix Salviae Miltiorrhizae 20g, Herba Houttuyniae 15g, Rhizoma Belamcandae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
Embodiment 2, the preparation of Tablets Example: get careless Mus tooth half 20g, Radix Inulae Pterocaulae 25g, Radix Caraganae Roseae 22g, Herba Sedi Bulbiferi 26g, Radix Angelicae Sinensis worm 18g, Rhizoma Chuanxiong 20g, Rhizoma Corydalis 25g, Bulbus Allii Macrostemonis 25g, Radix Curcumae 20g, Rhizoma Gastrodiae 20g, Herb Gynostemmae Pentaphylli 20g, Radix Et Caulis Acanthopanacis Senticosi 25g, Radix Salviae Miltiorrhizae 20g, Herba Houttuyniae 15g, Rhizoma Belamcandae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
Embodiment 3, the preparation of capsule embodiment: get careless Mus tooth half 20g, Radix Inulae Pterocaulae 25g, Radix Caraganae Roseae 22g, Herba Sedi Bulbiferi 26g, Radix Angelicae Sinensis worm 18g, Rhizoma Chuanxiong 20g, Rhizoma Corydalis 25g, Bulbus Allii Macrostemonis 25g, Radix Curcumae 20g, Rhizoma Gastrodiae 20g, Herb Gynostemmae Pentaphylli 20g, Radix Et Caulis Acanthopanacis Senticosi 25g, Radix Salviae Miltiorrhizae 20g, Herba Houttuyniae 15g, Rhizoma Belamcandae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment coronary heart disease of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation coronary heart disease case 70 example, 46 ~ 58 years old age.The shortest person of the course of disease 3 months, most elder reaches 2 years.
4.2 diagnostic criterias: after there is breastbone during (1) tired or psychentonia or precordial fullness pain, or tighten sample pain, and take on left, left upper arm radiation, continue 3-5 minute, spontaneous remission person after having a rest.(2) there is uncomfortable in chest, cardiopalmus during physical exertion, breathe hard, spontaneous remission person during rest.(3) there is the headache, toothache, skelalgia etc. relevant with motion.(4) heavy meal, cold or occur chest pain, heart-throb person when seeing adventure film.(5) when sleeping at night medicated pillow is low, feel chest distress, need high pillow clinostatism side to feel comfortable person; Sleep soundly or daytime is flat sleeping time unexpected chest pain, cardiopalmus, dyspnea, need sit up immediately or stand can the person of alleviation.(6) sexual life or firmly defecation time occur nervous, uncomfortable in chest, out of breath or chest pain is uncomfortable.(7) hear that noise just causes person nervous, uncomfortable in chest.(8) repeatedly occur that pulse is uneven, unknown cause heart beating is overrun or is crossed slow person.If belong to the high-risk group of coronary heart disease, will send for a doctor to check the need of accepting Electrocardioscopy.If desired further check, doctor can arrange to do an exercise test to measure the electrocardiogram when stepping on fixing feet car or step on exercise stress machine.Coronary artery revasualization is the method that diagnosis of coronary heart disease is affirmed most.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: after treatment, angina pectoris symptom disappears, and electrocardiogram recovers normal substantially.Effective: angina pectoris attacks number of times obviously reduces, pain relief, electrocardiogram is comparatively front to be improved.Invalid: angina pectoris attacks and electrocardiogram have no significant change.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 35 | 12 | 19 | 4 | 88.6 |
| Blank group | 35 | 1 | 1 | 33 | 5.7 |
Visible, the medicine that the present invention obtains can safe and effective treatment coronary heart disease, and have no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of coronary heart disease, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: careless Mus tooth half 20 parts, Radix Inulae Pterocaulae 25 parts, Radix Caraganae Roseae 22 parts, Herba Sedi Bulbiferi 26 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 20 parts, Rhizoma Corydalis 25 parts, Bulbus Allii Macrostemonis 25 parts, Radix Curcumae 20 parts, 20 parts, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli 20 parts, Radix Et Caulis Acanthopanacis Senticosi 25 parts, Radix Salviae Miltiorrhizae 20 parts, Herba Houttuyniae 15 parts, Rhizoma Belamcandae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of coronary heart disease as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of coronary heart disease as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment medicaments for coronary disease of coronary heart disease according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510645416.3A CN105126034A (en) | 2015-10-05 | 2015-10-05 | Pharmaceutical preparation for treating coronary heart disease |
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| CN201510645416.3A CN105126034A (en) | 2015-10-05 | 2015-10-05 | Pharmaceutical preparation for treating coronary heart disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091636A (en) * | 2018-10-30 | 2018-12-28 | 右江民族医学院 | A kind of strong medicine composition and preparation method thereof for treating coronary heart disease |
| CN109718319A (en) * | 2019-02-26 | 2019-05-07 | 宝鸡文理学院 | A kind of Chinese medicine composition and preparation method thereof for treating Cardiological coronary heart disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935195A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating coronary heart disease as well as preparation method and application thereof |
| CN104740585A (en) * | 2015-04-15 | 2015-07-01 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating coronary heart disease as well as preparation method and application of traditional Chinese medicine composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935195A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating coronary heart disease as well as preparation method and application thereof |
| CN104740585A (en) * | 2015-04-15 | 2015-07-01 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating coronary heart disease as well as preparation method and application of traditional Chinese medicine composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091636A (en) * | 2018-10-30 | 2018-12-28 | 右江民族医学院 | A kind of strong medicine composition and preparation method thereof for treating coronary heart disease |
| CN109091636B (en) * | 2018-10-30 | 2021-05-28 | 右江民族医学院 | Zhuang medicine formula for treating coronary heart disease and preparation method thereof |
| CN109718319A (en) * | 2019-02-26 | 2019-05-07 | 宝鸡文理学院 | A kind of Chinese medicine composition and preparation method thereof for treating Cardiological coronary heart disease |
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Application publication date: 20151209 |