CN105106540A - Medicinal preparation for treating cerebral thrombosis - Google Patents
Medicinal preparation for treating cerebral thrombosis Download PDFInfo
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- CN105106540A CN105106540A CN201510581342.1A CN201510581342A CN105106540A CN 105106540 A CN105106540 A CN 105106540A CN 201510581342 A CN201510581342 A CN 201510581342A CN 105106540 A CN105106540 A CN 105106540A
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Abstract
The invention belongs to the field of Chinese herb preparations, and particularly provides a medicinal preparation for treating cerebral thrombosis. The medicinal preparation is prepared from 20 parts of tiarella polyphylla, 18 parts of boenninghausenia albiflora, 22 parts of lobedfruit schizocapsa rhizome, 25 parts of oreocharis benthamii, 18 parts of caulis spatholobi, 20 parts of panax ginseng, 15 parts of angelica sinensis, 25 parts of salvia miltiorrhiza, 20 parts of ligusticum wallichii, 20 parts of leonurus japonicus, 20 parts of polygonum cuspidatum, 25 parts of radix paeoniae alba, 20 parts of cortex cinnamomi, 15 parts of Chinese yam, 15 parts of prunella vulgaris and 5 parts of liquorice. The medicinal preparation is capable of treating cerebral thrombosis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis and its preparation method and application.
Background technology
Cerebral thrombosis is the modal type of cerebral infarction.Be that cerebral arteries trunk or cortical branches atherosclerosis cause Aldosterone, luminal stenosis obturation and thrombosis, cause brain regional blood flow to reduce or blood supply interruption, brain tissue ischemia anoxia causes the focal neurological symptom of softening downright bad appearance.China's 1986 ~ nineteen ninety large-scale crowd investigation display, Cerebral Haemorrhage Invasion Rate is 109.7/10 ten thousand ~ 2,17/,100,000, and prevalence is 7,19/,100,000 ~ 745.6/10 ten thousand, and mortality rate is 1,16/,100,000 ~ 141.8/10 ten thousand.Male's sickness rate is higher than women, and male: female is 1.3: 1 ~ 1.7: 1.For this reason, be bursting to and develop the needs that more medicines for the treatment of cerebral thrombosis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of cerebral thrombosis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: 25 parts, lotus, Caulis Spatholobi 18 parts, Radix Ginseng 20 parts, Radix Angelicae Sinensis 15 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Chuanxiong 20 parts, Herba Leonuri 20 parts, Rhizoma Polygoni Cuspidati 20 parts, the Radix Paeoniae Alba 25 parts, Cortex Cinnamomi 20 parts, Rhizoma Dioscoreae 15 parts, Spica Prunellae 15 parts, 5 parts, Radix Glycyrrhizae on Herba tiarellae polyphyllae 20 parts, Boenninghausenia albiflora 18 parts, Rhizoma Schizocapsae Plantagineae 22 parts, stone.
The described pharmaceutical preparation being used for the treatment of cerebral thrombosis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of cerebral thrombosis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment cerebral thrombosis medicine being used for the treatment of cerebral thrombosis.
Herba tiarellae polyphyllae is Saxifragaceae Herba tiarellae polyphyllae platymiscium Herba tiarellae polyphyllae TiarellapolyphyllaD.Don, with all herbal medicine.Xia Qiu gathers, and dries.Hardship, cold.Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For carbuncle furuncle and phyma poison, traumatic injury, hepatitis, cough and asthma.
Boenninghausenia albiflora is the herb of Rutaceae pine wind grass platymiscium Boenninghausenia albiflora Boenninghauseniaalbiflora (Hook.) Meiss..Xia Qiu gathers, and dries in the shade.Induce sweat preventing the attack (or recurrence) of malaria, promoting blood circulation to remove blood stasis, removing toxic substances.For malaria, cold, fever, bronchitis, traumatic injury; Traumatic hemorrhage is controlled in external, carbuncle furuncle infections.
Rhizoma Schizocapsae Plantagineae is Rhizoma amorphophalli potato section (spider's thread grass section, Tacca chantrieri section) dehiscent fruit potato platymiscium dehiscent fruit potato SchizocapsaplantagineaHanceTaccaplantaginea (Hance) Drenth., is used as medicine with tuber.The four seasons can adopt, and clean, remove fibrous root, using fresh herb or dry.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, regulating QI to relieve pain, preventing the attack (or recurrence) of malaria.For laryngopharynx swelling and pain, acute gastroenteritis, urinary tract infection, toothache, chronic gastritis, taste-blindness rate, rheumatic arthritis, menoxenia, malaria, traumatic injury; Sore swollen toxin is controlled in external, traumatic hemorrhage.
Shi Shanglian is Gesneriaceae herbaceos perennial.Classification system Oreocharisbenthamii, controls the diseases such as traumatic injury.Removing damp-heat, diuretic softening the hard mass, reducing swelling and alleviating pain.Treating hepatocirrhosis, ascites, summer-heat is thirsty.Treating swelling and pain by traumatic injury is controlled in external, furuncle swelling toxin.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: cerebral thrombosis belongs to the traditional Chinese medical science " apoplexy " category.Apoplexy is that first of the traditional Chinese medical science four disaster card, the four seasons all can fall ill, and stay sequela more.The theory of apoplexy comes from "Nei Jing", forms in " Medical Treasures of the Golden Chamber ", and ancient Chinese medicine doctor thinks many caused by wind, fire, expectorant, the stasis of blood, void.Cerebral thrombosis acute phase is real based on the mark of wind, fire, expectorant, the stasis of blood, poison, in blood stagnant in cerebral venation syndrome, all heresies, biochemical poison damage brains are acute stage pathology key, and convalescent period is to suffer from a deficiency of the kidney (deficiency of vital energy, the deficiency of YIN), the deficient deficiency in origin of brains is main, sequela stage mostly is dead blood pertinacious phlegm and deeply stays brain network, caused by brain inanition.It is monarch drug that brain is protected in Herba tiarellae polyphyllae of the present invention, Boenninghausenia albiflora, Rhizoma Schizocapsae Plantagineae, Shi Shanglian, Caulis Spatholobi, Radix Ginseng, Radix Angelicae Sinensis heat-clearing and toxic substances removing, eliminating evil removing toxic substances, the kidney invigorating, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Rhizoma Polygoni Cuspidati, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Dioscoreae, Spica Prunellae blood circulation promoting and blood stasis dispelling, enriching yin and nourishing kidney are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment cerebral thrombosis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba tiarellae polyphyllae 20g, Boenninghausenia albiflora 18g, Rhizoma Schizocapsae Plantagineae 22g, lotus 25g on stone, Caulis Spatholobi 18g, Radix Ginseng 20g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 25g, Rhizoma Chuanxiong 20g, Herba Leonuri 20g, Rhizoma Polygoni Cuspidati 20g, Radix Paeoniae Alba 25g, Cortex Cinnamomi 20g, Rhizoma Dioscoreae 15g, Spica Prunellae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba tiarellae polyphyllae 20g, Boenninghausenia albiflora 18g, Rhizoma Schizocapsae Plantagineae 22g, lotus 25g on stone, Caulis Spatholobi 18g, Radix Ginseng 20g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 25g, Rhizoma Chuanxiong 20g, Herba Leonuri 20g, Rhizoma Polygoni Cuspidati 20g, Radix Paeoniae Alba 25g, Cortex Cinnamomi 20g, Rhizoma Dioscoreae 15g, Spica Prunellae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba tiarellae polyphyllae 20g, Boenninghausenia albiflora 18g, Rhizoma Schizocapsae Plantagineae 22g, lotus 25g on stone, Caulis Spatholobi 18g, Radix Ginseng 20g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 25g, Rhizoma Chuanxiong 20g, Herba Leonuri 20g, Rhizoma Polygoni Cuspidati 20g, Radix Paeoniae Alba 25g, Cortex Cinnamomi 20g, Rhizoma Dioscoreae 15g, Spica Prunellae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment cerebral thrombosis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation cerebral thrombosis case 100 example, 46 ~ 67 years old age.The shortest person of the course of disease 6 months, most elder reaches 4 years.
4.2 diagnostic criterias: (1) has the sings and symptoms of cerebral arteriosclerosis, and onset was in more than 45 years old person.(2) reasons such as intracranial tumor, inflammation, poisoning, wound are eliminated.(3) history of hypertension is had, the hypertension particularly more than II phase.(4) performance of ocular fundus arteriosclerosis is had.(5) cardiovascular system and other positions have some arteriosclerosis: the clinical and ECG change of coronary atherosclerosis, and the x-ray of aortosclerosis is levied, carotid artery, subclavian artery noise, and the sclerosis of oar, temporo, dorsal artery of foot is levied.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptoms disappears completely, and linguistic competence and self-care ability are recovered substantially, and muscular strength rises to more than III grade before comparatively treating; (2) effective: clinical symptoms disappears substantially, linguistic competence recovers, and substantially can take care of oneself, and muscular strength rises to more than II grade before comparatively treating; (3) effective: clinical symptoms is alleviated to some extent, and life cannot be taken care of oneself, and muscular strength returns to more than I grade before comparatively treating; (4) invalid: any change does not appear in clinical symptoms, and even the state of an illness is more and more serious.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 50 | 8 | 11 | 23 | 8 | 84 |
| Blank group | 50 | 1 | 1 | 1 | 47 | 6 |
Visible, the medicine that the present invention obtains can safe and effective treatment cerebral thrombosis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of cerebral thrombosis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: 25 parts, lotus, Caulis Spatholobi 18 parts, Radix Ginseng 20 parts, Radix Angelicae Sinensis 15 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Chuanxiong 20 parts, Herba Leonuri 20 parts, Rhizoma Polygoni Cuspidati 20 parts, the Radix Paeoniae Alba 25 parts, Cortex Cinnamomi 20 parts, Rhizoma Dioscoreae 15 parts, Spica Prunellae 15 parts, 5 parts, Radix Glycyrrhizae on Herba tiarellae polyphyllae 20 parts, Boenninghausenia albiflora 18 parts, Rhizoma Schizocapsae Plantagineae 22 parts, stone.
2. be used for the treatment of the pharmaceutical preparation of cerebral thrombosis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of cerebral thrombosis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment cerebral thrombosis medicine of cerebral thrombosis according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510581342.1A CN105106540A (en) | 2015-09-14 | 2015-09-14 | Medicinal preparation for treating cerebral thrombosis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510581342.1A CN105106540A (en) | 2015-09-14 | 2015-09-14 | Medicinal preparation for treating cerebral thrombosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111356469A (en) * | 2017-10-27 | 2020-06-30 | 韩国韩医药振兴院 | Antithrombotic composition comprising rhizoma Polygoni Cuspidati and cortex Cinnamomi |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951481A (en) * | 2006-10-12 | 2007-04-25 | 张元道 | Medicament for treating cerebral thrombosis |
| CN1985965A (en) * | 2006-07-23 | 2007-06-27 | 李锡尧 | Medicine for treating coronary heart disease and cerebral thrombus and its preparing method |
| CN103479896A (en) * | 2013-09-30 | 2014-01-01 | 周复礼 | Medicament for treating cerebral thrombosis and preparation method of medicament |
-
2015
- 2015-09-14 CN CN201510581342.1A patent/CN105106540A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985965A (en) * | 2006-07-23 | 2007-06-27 | 李锡尧 | Medicine for treating coronary heart disease and cerebral thrombus and its preparing method |
| CN1951481A (en) * | 2006-10-12 | 2007-04-25 | 张元道 | Medicament for treating cerebral thrombosis |
| CN103479896A (en) * | 2013-09-30 | 2014-01-01 | 周复礼 | Medicament for treating cerebral thrombosis and preparation method of medicament |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111356469A (en) * | 2017-10-27 | 2020-06-30 | 韩国韩医药振兴院 | Antithrombotic composition comprising rhizoma Polygoni Cuspidati and cortex Cinnamomi |
| JP2021501207A (en) * | 2017-10-27 | 2021-01-14 | 韓國韓醫藥振興院Ｎａｔｉｏｎａｌ Ｉｎｓｔｉｔｕｔｅ ｆｏｒ Ｋｏｒｅａｎ Ｍｅｄｉｃｉｎｅ Ｄｅｖｅｌｏｐｍｅｎｔ | Antithrombotic composition containing Japanese knotweed and cinnamon |
| EP3701961A4 (en) * | 2017-10-27 | 2021-07-21 | National Institute for Korean Medicine Development | Antithrombotic composition containing polygonum cuspidatum sieb. et zucc. and cinnamomum cassia blume |
| CN111356469B (en) * | 2017-10-27 | 2022-05-27 | 韩国韩医药振兴院 | Composition comprising rhizoma Polygoni Cuspidati root and cortex Cinnamomi for resisting thrombi |
| JP7412712B2 (en) | 2017-10-27 | 2024-01-15 | 韓國韓醫藥振興院 | An antithrombotic composition containing Japanese knotweed and Japanese knotweed, an antithrombotic health food containing the same, and a method for producing an antithrombotic active ingredient |
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