CN105288285A - Medicinal preparation for treating chronic bronchitis - Google Patents

Medicinal preparation for treating chronic bronchitis Download PDF

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Publication number
CN105288285A
CN105288285A CN201510771400.7A CN201510771400A CN105288285A CN 105288285 A CN105288285 A CN 105288285A CN 201510771400 A CN201510771400 A CN 201510771400A CN 105288285 A CN105288285 A CN 105288285A
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China
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parts
chronic bronchitis
treatment
pharmaceutical preparation
folium
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CN201510771400.7A
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Chinese (zh)
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赵明亮
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Nanjing Zhengliang Pharmaceutical Technology Co Ltd
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Nanjing Zhengliang Pharmaceutical Technology Co Ltd
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Priority to CN201510771400.7A priority Critical patent/CN105288285A/en
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention specifically provides a medicinal preparation for treating chronic bronchitis, belonging to the field of medicine. The medicinal preparation is prepared from the following raw materials: 20 parts of Schoepfia chinensis, 25 parts of Prinsepia utilis Royle., 18 parts of root of Inula nervosa Wall., 15 parts of Juncellus serotinus, 10 parts of rhizome of largeleaf curculigo, 10 parts of balloonflower root, 15 parts of catnip, 15 parts of lily, 15 parts of white peony root, 10 parts of perilla, 10 parts of tabasheer, 10 parts of bitter apricot kernel, 10 parts of mulberry bark, 15 parts of pubescent holly root and 5 parts of licorice. The medicinal preparation can treat chronic bronchitis.

Description

A kind of pharmaceutical preparation being used for the treatment of chronic bronchitis
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic bronchitis and its preparation method and application.
Background technology
Chronic bronchitis refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.A kind of commonly encountered diseases of serious harm health of people, especially common with old people.Chronic tracheitis is not treated in time by acute bronchitis, and through repeated infection, long-time stimulus causes.Chronic bronchitis to cough, expectorant, breathe heavily for main clinic symptoms, patient may cough several months continuously, if the state of an illness continues progress, Chang Bingfa obstructive emphysema, pulmonary hypertension, pulmonary heart disease, serious even entail dangers to patient vitals.Chronic bronchitis belongs to commonly encountered diseases, chronic disease, frequently-occurring disease, because Western medicine effect is single, often needs drug combination and intravenously administrable, can only play certain control action, only cure the symptoms, not the disease to the acute attack of this disease.For the treatment of chronic bronchitis, treatment by Chinese herbs effect is slightly better than western medicine, but after drug withdrawal, often again recurs because of diseases such as flu.Comparatively common clinically, because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of chronic bronchitis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic bronchitis diseases.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic bronchitis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: magnificent Ramulus et Folium Schoepfiae chinesis 20 parts, Folium Prinsepiae Utilis 25 parts, Wheeling chrysanthemum 18 parts, Herba Cyperi Glomerati 15 parts, Rhizoma Curculiginis Capitulatae 10 parts, Radix Platycodonis 10 parts, Herba Schizonepetae 15 parts, Bulbus Lilii 15 parts, the Radix Paeoniae Alba 15 parts, Folium Perillae 10 parts, Concretio Silicea Bambusae 10 parts, Semen Armeniacae Amarum 10 parts, Cortex Mori 10 parts, Radix Ilicis Pubescentis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic bronchitis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic bronchitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic bronchitis medicine being used for the treatment of chronic bronchitis.
China's Ramulus et Folium Schoepfiae chinesis is that Ramulus et Folium Schoepfiae chinesis belongs to (Schoepfia) fragrant cottonrose hibiscus wood group (Sect.Alloschoepfia) plant, is the root of Olacaceae plant Ramulus et Folium Schoepfiae chinesis daughter nucleus.Clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.Root: for acute icterohepatitis.
Folium Prinsepiae Utilis, Classification system: PrinsepiautilisRoyle., Rosaceae Prinsepia Royle plant Folium Prinsepiae Utilis, is used as medicine with root, leaf and fruit.Root can be adopted the whole year; Leaf, fruit Xia Qiucai.The present invention is used as medicine with root.Root, leaf: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.For lymphadenitis, parotitis, mastitis, rheumatic arthritis, hemorrhoid, traumatic injury, menoxenia, anemia, gingival hemorrhage.Really: invigorating the stomach and promoting digestion.For dyspepsia.
Wheeling chrysanthemum is that Compositae Inulaplants shows arteries and veins Flos Inulae InulanervosaWall., is used as medicine with root.Autumn excavates, and cleans, dries.Expelling wind and removing dampness, activating collaterals to relieve pain, invigorating the stomach and promoting digestion.For rheumatalgia, soreness of the waist and knees, inappetence, stomachache.
Herba Cyperi Glomerati is the herb of the spherical dried tuber of sedge.
Rhizoma Curculiginis Capitulatae is the rhizome of amrallid great Ye Rhizoma Curculiginis.All the other medical materials are pharmacopeia kind.
Beneficial effect: chronic bronchitis, belongs to the category such as " cough ", " phlegm retention ", " asthma ", " the syndrome of dyspnea " of Chinese medicine.Etiology and pathogenesis is complicated, and its intrinsic factor are relevant with internal organs." vital organs of the human body all make us coughing, and non-only lung is also ", but wherein in close relations with spleen, lung, kidney.Because insufficiency of lung-QI, Wei Yang is not solid, and striae of the skin and muscles being loose, easily perspires, and normal easy catching a cold brings out bronchitis.Therefore the present invention China Ramulus et Folium Schoepfiae chinesis, Folium Prinsepiae Utilis, Wheeling chrysanthemum, Herba Cyperi Glomerati, Rhizoma Curculiginis Capitulatae, Radix Platycodonis, Herba Schizonepetae heat-clearing and toxic substances removing, moistening the lung and resolving phlegm are monarch drug, Bulbus Lilii, the Radix Paeoniae Alba, Folium Perillae, Concretio Silicea Bambusae, Semen Armeniacae Amarum, Cortex Mori, Radix Ilicis Pubescentis are regulated the flow of vital energy YIN nourishing, strengthening spleen, tonifying kidney, strengthening vital QI to eliminate pathogenic factors is ministerial drug, Radix Glycyrrhizae is adjuvant, mutual compatibility, treatment chronic bronchitis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get magnificent Ramulus et Folium Schoepfiae chinesis 20g, Folium Prinsepiae Utilis 25g, Wheeling chrysanthemum 18g, Herba Cyperi Glomerati 15g, Rhizoma Curculiginis Capitulatae 10g, Radix Platycodonis 10g, Herba Schizonepetae 15g, Bulbus Lilii 15g, Radix Paeoniae Alba 15g, Folium Perillae 10g, Concretio Silicea Bambusae 10g, Semen Armeniacae Amarum 10g, Cortex Mori 10g, Radix Ilicis Pubescentis 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get magnificent Ramulus et Folium Schoepfiae chinesis 20g, Folium Prinsepiae Utilis 25g, Wheeling chrysanthemum 18g, Herba Cyperi Glomerati 15g, Rhizoma Curculiginis Capitulatae 10g, Radix Platycodonis 10g, Herba Schizonepetae 15g, Bulbus Lilii 15g, Radix Paeoniae Alba 15g, Folium Perillae 10g, Concretio Silicea Bambusae 10g, Semen Armeniacae Amarum 10g, Cortex Mori 10g, Radix Ilicis Pubescentis 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get magnificent Ramulus et Folium Schoepfiae chinesis 20g, Folium Prinsepiae Utilis 25g, Wheeling chrysanthemum 18g, Herba Cyperi Glomerati 15g, Rhizoma Curculiginis Capitulatae 10g, Radix Platycodonis 10g, Herba Schizonepetae 15g, Bulbus Lilii 15g, Radix Paeoniae Alba 15g, Folium Perillae 10g, Concretio Silicea Bambusae 10g, Semen Armeniacae Amarum 10g, Cortex Mori 10g, Radix Ilicis Pubescentis 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, chronic chronic bronchitis clinical research is treated in pharmaceutical preparation of the present invention
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic bronchitis example 50 example, wherein, 26 ~ 57 years old age.
4.2 diagnostic criterias: (1) cough, expectoration or companion pant, annual morbidity 3 months, continuous 2 years or more persons.(2) fall ill less than 3 months every year, and have clear and definite objective determination also diagnosable according to (as x-ray, lung function tests etc.) person.(3) other hearts, lung disease (as pulmonary tuberculosis, asthma, bronchiectasis, pulmonary carcinoma, heart disease etc.) person can be got rid of.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) fully recovers: symptom and sign disappear.(2) take a turn for the better: symptom and sign alleviate or partial disappearance.(3) invalid: unchanged after treatment.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Treatment group 25 8 13 4 84
Blank group 25 2 2 21 16
Visible, the medicine that the present invention obtains can the chronic chronic bronchitis of safe and effective treatment, and has no side effect in use procedure.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of chronic bronchitis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: magnificent Ramulus et Folium Schoepfiae chinesis 20 parts, Folium Prinsepiae Utilis 25 parts, Wheeling chrysanthemum 18 parts, Herba Cyperi Glomerati 15 parts, Rhizoma Curculiginis Capitulatae 10 parts, Radix Platycodonis 10 parts, Herba Schizonepetae 15 parts, Bulbus Lilii 15 parts, the Radix Paeoniae Alba 15 parts, Folium Perillae 10 parts, Concretio Silicea Bambusae 10 parts, Semen Armeniacae Amarum 10 parts, Cortex Mori 10 parts, Radix Ilicis Pubescentis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic bronchitis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic bronchitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic bronchitis medicine of chronic bronchitis according to claim 1.
CN201510771400.7A 2015-11-12 2015-11-12 Medicinal preparation for treating chronic bronchitis Pending CN105288285A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105944070A (en) * 2016-07-02 2016-09-21 姚鲁肃 Medicine preparation for treating intensive care respiratory system infection and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105944070A (en) * 2016-07-02 2016-09-21 姚鲁肃 Medicine preparation for treating intensive care respiratory system infection and preparation method thereof

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Application publication date: 20160203