CN109718319A - A kind of Chinese medicine composition and preparation method thereof for treating Cardiological coronary heart disease - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating Cardiological coronary heart disease Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition and preparation method thereof for treating Cardiological coronary heart disease, which includes the raw material components of following parts by weight: 15~20 parts of Radix Angelicae Sinensis, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of safflower, 5~10 parts of rhizoma pinellinae praeparata, 6~12 parts of Clematis kerriana Drumm. Et Craiab, 5~10 parts of the dried immature fruit of citron orange, 3~8 parts of snakegourd, 3~8 parts of Longstamen Onion Bulb, 2~6 parts of Herba Siegesbeckiae, 2~6 parts of caulis lonicerae.The invention also discloses the preparation methods of above-mentioned Chinese medicine composition, and above-mentioned each raw material component is mixed, crush, decoct, filter and is concentrated, and medically acceptable auxiliary material is added so that the drug of different dosage forms is made, and have good therapeutic effect for coronary heart disease.Treatment Cardiological coronary heart disease Chinese medicine composition provided by the invention has drawn from a variety of Chinese herbal medicines, obvious for coronary heart disease treatment effect, and medical expense is low, quick, uneasy to recur；It is without any side effects simultaneously, avoid the damage caused by human body of traditional chemical drug therapy.
Description
Technical field
The invention belongs to drug preparation technique fields, and in particular to a kind of Chinese medicine composition for treating Cardiological coronary heart disease and
Preparation method.
Background technique
Coronary heart disease is the abbreviation of coronary heart disease, is a kind of most common heart disease, refer to because coronary artery stenosis,
Myocardial dysfunction and organic disease caused by blood supply insufficiency, therefore also known as ischemic heart disease.Cause the main original of this disease
Because being that chronic dietary is improper and body deficiency due to old age, inward invasion of pathogenic cold, disorder of emotion, mostly immediate cause or inducement.Due to Incidence of CHD
High, death rate height, seriously endangers the health of the mankind, is referred to as " the first killer of the mankind ".
Currently, the medicament categories for the treatment of coronary heart disease are various, most of is western medical treatment, palliative.Its therapy approach
The drug of coronary dilatation and reducing heart rate is mostly used, myocardial oxygen delivery is improved and reduces myocardial oxygen consumption, to mitigate state of an illness symptom.Practice card
Bright, though this kind of drug can alleviate illness to a certain extent, it is sorry up to effecting a permanent cure that there is impairment of yin, gas consumption, hardly possiblies always.Usually
The state of an illness is better when being medication, the original state of an illness is returned to once being discontinued, if inappropriate medication, it is also possible to which treatment is in vain even
Aggravate illness.
Summary of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of Chinese traditional medicine compositions for treating Cardiological coronary heart disease
Object and preparation method thereof.
The first purpose of the invention is to provide a kind of Chinese medicine compositions for treating Cardiological coronary heart disease, including following weight
The raw material components of number: 15~20 parts of Radix Angelicae Sinensis, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of safflower, 5~10 parts of rhizoma pinellinae praeparata, Clematis kerriana Drumm. Et Craiab 6~
12 parts, 5~10 parts of the dried immature fruit of citron orange, 3~8 parts of snakegourd, 3~8 parts of Longstamen Onion Bulb, 2~6 parts of Herba Siegesbeckiae, 2~6 parts of caulis lonicerae.
Preferably, the Chinese medicine composition of the treatment Cardiological coronary heart disease, the raw material components including following parts by weight: Radix Angelicae Sinensis
20 parts, 10 parts of Rhizoma Chuanxiong, 15 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 10 parts of Clematis kerriana Drumm. Et Craiab, 5 parts of the dried immature fruit of citron orange, 3 parts of snakegourd, 3 parts of Longstamen Onion Bulb, Herba Siegesbeckiae 2
Part, 5 parts of caulis lonicerae.
Preferably, the Chinese medicine composition of the treatment Cardiological coronary heart disease, the raw material components including following parts by weight: Radix Angelicae Sinensis
15 parts, 15 parts of Rhizoma Chuanxiong, 10 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 6 parts of Clematis kerriana Drumm. Et Craiab, 8 parts of the dried immature fruit of citron orange, 8 parts of snakegourd, 8 parts of Longstamen Onion Bulb, Herba Siegesbeckiae 2
Part, 6 parts of caulis lonicerae.
A second object of the present invention is to provide a kind of preparation sides of the Chinese medicine composition of above-mentioned treatment Cardiological coronary heart disease
Method, comprising the following steps:
S1, weigh respectively in parts by weight 15~20 parts of Radix Angelicae Sinensis, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of safflower, rhizoma pinellinae praeparata 5~
10 parts, 6~12 parts of Clematis kerriana Drumm. Et Craiab, 5~10 parts of the dried immature fruit of citron orange, 3~8 parts of snakegourd, 3~8 parts of Longstamen Onion Bulb, 2~6 parts of Herba Siegesbeckiae, caulis lonicerae 2~6
Part, it is spare；
S2, each raw material component weighed in S1 is mixed, and is crushed to the particle of 100 mesh or more；
S3, it particle obtained in S2 is added water to cook obtains decocting medical fluid three times, merge to decoct three times and medical fluid and filter
To the first filtrate, the relative density being concentrated under reduced pressure at the first filtrate to 65~80 DEG C is 1.12~1.28, obtains the first concentrate；
S4, ethyl alcohol is added into the first concentrate that S3 is obtained, stirs, stand, the second filtrate is obtained by filtration, be concentrated under reduced pressure
Relative density at filtrate to 80~95 DEG C is 1.28~1.35, obtains the second concentrate；
S5, into the second concentrate obtained in S4, oral solution, capsule, tablet or granule is made in addition auxiliary material.
Preferably, in step s3, decocting amount of water for the first time is 6~8 times of medicinal material amount, decocts 2~4 hours, second
The secondary amount of water that decocts is 4~6 times of medicinal material amount, is decocted 2~3 hours, third time decocts 2~4 times that amount of water is medicinal material amount, pan-fried
It boils 1~2 hour.
Preferably, in step s 4, the percent by volume of the ethyl alcohol and the first concentrate is 70~75%.
Preferably, in step s 5, the auxiliary material is sucrose, starch, methylcellulose, carboxymethyl cellulose sodium, stearic acid
One of magnesium, superfine silica gel powder, lauryl sodium sulfate, hydroxypropyl methyl cellulose, talcum powder or more than one combinations.
The pharmacological action of each component in the traditional chinese medicine composition of the invention:
It is sweet in flavor, pungent when being classified as monarch drug in a prescription, it is warm-natured；Return liver, the heart, the spleen channel.With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, relax bowel and defecation
Effect can dramatically increase coronary blood flow, reduce myocardial oxygen consumption.Safflower is ministerial drug, and promoting blood circulation, dredging collateral are reduced swelling, and worked as
Return compatibility, to enhance the antiatherosclerosis of Radix Angelicae Sinensis, reduces blood lipid, it is anti-oxidant, remove the function of free radical.Adjutant is Rhizoma Chuanxiong,
Blood-activating and qi-promoting, rhizome of chuanxiong flower share, and promote clearing and activating the channels and collaterals and expand the enhancing of blood vessel；Rhizoma pinellinae praeparata is pungent, warm, returns spleen, stomach, lung channel, eliminating dampness
Resolving sputum, dissolving lump and resolving mass, Clematis kerriana Drumm. Et Craiab bitter, cold nature, clearing heat and detoxicating, diuresis, eliminating blood stasis and smoothing collaterals, the dried immature fruit of citron orange, snakegourd and Longstamen Onion Bulb are to make medicine,
It is antipyretic to quench the thirst, kobadrin, promoting the circulation of qi promoting.Herba Siegesbeckiae remove rheumatism, strong muscles and bones are clearing heat and detoxicating, caulis lonicerae and Herba Siegesbeckiae phase
Clearing heat and detoxicating with the use of enhancing, the effect of dispelling wind dredging collateral, all medicine collaborations work, benefiting qi and nourishing blood, remove obstruction in channels to relieve pain, eliminating the phlegm is by the stasis of blood,
Therefore new blood life, phlegm-blood stasis are gone, all diseases are removed certainly.
Compared with prior art, the beneficial effects of the present invention are:
The Chinese medicine composition for the treatment of Cardiological coronary heart disease provided by the invention, have drawn from a variety of Chinese herbal medicines, for coronary heart disease
Therapeutic effect is obvious, and medical expense is low, quick, uneasy to recur；It is without any side effects simultaneously, avoid traditional chemical drug
Treatment is damaged caused by human body.The traditional Chinese medicinal components object can formulation method routinely be made oral solution, capsule, tablet or
Granule is improved using popularity.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
The test method of actual conditions is not specified in following embodiments, according to conventional methods in the art with condition into
Row, raw materials used is commercially available.
Embodiment 1
A kind of Chinese medicine composition for treating Cardiological coronary heart disease, specifically includes the raw material components of following parts by weight: Radix Angelicae Sinensis
20 parts, 10 parts of Rhizoma Chuanxiong, 15 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 10 parts of Clematis kerriana Drumm. Et Craiab, 5 parts of the dried immature fruit of citron orange, 3 parts of snakegourd, 3 parts of Longstamen Onion Bulb, Herba Siegesbeckiae 2
Part, 5 parts of caulis lonicerae.
The preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease provided in an embodiment of the present invention, specifically includes as follows
Step:
S1,20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, 15 parts of safflower, 10 parts of rhizoma pinellinae praeparata, Clematis kerriana Drumm. Et Craiab 10 are weighed respectively in parts by weight
Part, 5 parts of the dried immature fruit of citron orange, 3 parts of snakegourd, 3 parts of Longstamen Onion Bulb, 2 parts of Herba Siegesbeckiae, 5 parts of caulis lonicerae are spare；
S2, each raw material component weighed in S1 is mixed, and is crushed to the particle of 200 mesh；
S3, particle obtained in S2 is added water to cook obtain three times decoct medical fluid, wherein for the first time decoct amount of water be medicine
8 times of material amount decoct 4 hours, and it is 6 times of medicinal material amount that second, which decocts amount of water, decoct 3 hours, third time decocts amount of water
It is 4 times of medicinal material amount, decocts 2 hours, is then combined with and decocts medical fluid three times and the first filtrate is obtained by filtration, the first filter is concentrated under reduced pressure
Relative density at liquid to 80 DEG C is 1.28, obtains the first concentrate；
S4, it is added ethyl alcohol into the first concentrate that S3 is obtained, the percent by volume of ethyl alcohol and the first concentrate is 70%,
Stirring is stood, and the second filtrate is obtained by filtration, and the relative density being concentrated under reduced pressure at filtrate to 95 DEG C is 1.35, obtains the second concentration
Liquid；
S5, auxiliary material sucrose, methylcellulose, magnesium stearate, talcum powder are added into the second concentrate obtained in S4, mix
Even, granulation arranges classification, and particle obtained is directly packed, granule is made.
Embodiment 2
A kind of Chinese medicine composition for treating Cardiological coronary heart disease, specifically includes the raw material components of following parts by weight: Radix Angelicae Sinensis
15 parts, 15 parts of Rhizoma Chuanxiong, 10 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 6 parts of Clematis kerriana Drumm. Et Craiab, 8 parts of the dried immature fruit of citron orange, 8 parts of snakegourd, 8 parts of Longstamen Onion Bulb, Herba Siegesbeckiae 2
Part, 6 parts of caulis lonicerae.
The preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease provided in an embodiment of the present invention, specifically includes as follows
Step:
S1, weigh respectively in parts by weight 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiong, 10 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 6 parts of Clematis kerriana Drumm. Et Craiab,
8 parts of the dried immature fruit of citron orange, 8 parts of snakegourd, 8 parts of Longstamen Onion Bulb, 2 parts of Herba Siegesbeckiae, 6 parts of caulis lonicerae, it is spare；
S2, each raw material component weighed in S1 is mixed, and is crushed to the particle of 300 mesh；
S3, particle obtained in S2 is added water to cook obtain three times decoct medical fluid, wherein for the first time decoct amount of water be medicine
6 times of material amount decoct 6 hours, and it is 4 times of medicinal material amount that second, which decocts amount of water, decoct 2 hours, third time decocts amount of water
It is 2 times of medicinal material amount, decocts 1 hour, is then combined with and decocts medical fluid three times and the first filtrate is obtained by filtration, the first filter is concentrated under reduced pressure
Relative density at liquid to 65 DEG C is 1.12, obtains the first concentrate；
S4, it is added ethyl alcohol into the first concentrate that S3 is obtained, the percent by volume of ethyl alcohol and the first concentrate is 75%,
Stirring is stood, and the second filtrate is obtained by filtration, and the relative density being concentrated under reduced pressure at filtrate to 80 DEG C is 1.28, obtains the second concentration
Liquid；
S5, supplementary product starch, methylcellulose, carboxymethyl cellulose sodium, tristearin are added into the second concentrate obtained in S4
Sour magnesium mixes, granulation, dry, tabletting, tablet is made.
Embodiment 3
A kind of Chinese medicine composition for treating Cardiological coronary heart disease, specifically includes the raw material components of following parts by weight: 18 parts,
10 parts of Rhizoma Chuanxiong, 5 parts of rhizoma pinellinae praeparata, 12 parts of Clematis kerriana Drumm. Et Craiab, 10 parts of the dried immature fruit of citron orange, 5 parts of snakegourd, 5 parts of Longstamen Onion Bulb, 6 parts of Herba Siegesbeckiae, is born 12 parts of safflower
2 parts of winter rattan.
The preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease provided in an embodiment of the present invention, specifically includes as follows
Step:
S1, weigh respectively in parts by weight 18 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, 12 parts of safflower, 5 parts of rhizoma pinellinae praeparata, 12 parts of Clematis kerriana Drumm. Et Craiab,
10 parts of the dried immature fruit of citron orange, 5 parts of snakegourd, 5 parts of Longstamen Onion Bulb, 6 parts of Herba Siegesbeckiae, 2 parts of caulis lonicerae, it is spare；
S2, each raw material component weighed in S1 is mixed, and is crushed to the particle of 150 mesh；
S3, particle obtained in S2 is added water to cook obtain three times decoct medical fluid, wherein for the first time decoct amount of water be medicine
8 times of material amount decoct 4 hours, and it is 6 times of medicinal material amount that second, which decocts amount of water, decoct 2 hours, third time decocts amount of water
It is 4 times of medicinal material amount, decocts 1 hour, is then combined with and decocts medical fluid three times and the first filtrate is obtained by filtration, the first filter is concentrated under reduced pressure
Relative density at liquid to 70 DEG C is 1.21, obtains the first concentrate；
S4, it is added ethyl alcohol into the first concentrate that S3 is obtained, the percent by volume of ethyl alcohol and the first concentrate is 70%,
Stirring is stood, and the second filtrate is obtained by filtration, and the relative density being concentrated under reduced pressure at filtrate to 85 DEG C is 1.32, obtains the second concentration
Liquid；
S5, supplementary product starch, superfine silica gel powder, lauryl sodium sulfate, hydroxypropyl are added into the second concentrate obtained in S4
Ylmethyl cellulose mixes, granulation, drying, is filled into capsule shells, capsule is made.
Embodiment 4
A kind of Chinese medicine composition for treating Cardiological coronary heart disease, specifically includes the raw material components of following parts by weight: Radix Angelicae Sinensis
15 parts, 10 parts of Rhizoma Chuanxiong, 10 parts of safflower, 5 parts of rhizoma pinellinae praeparata, 12 parts of Clematis kerriana Drumm. Et Craiab, 5 parts of the dried immature fruit of citron orange, 3 parts of snakegourd, 5 parts of Longstamen Onion Bulb, Herba Siegesbeckiae 3
Part, 5 parts of caulis lonicerae.
The preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease provided in an embodiment of the present invention, specifically includes as follows
Step:
S1, weigh respectively in parts by weight 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, 10 parts of safflower, 5 parts of rhizoma pinellinae praeparata, 12 parts of Clematis kerriana Drumm. Et Craiab,
5 parts of the dried immature fruit of citron orange, 3 parts of snakegourd, 5 parts of Longstamen Onion Bulb, 3 parts of Herba Siegesbeckiae, 5 parts of caulis lonicerae, it is spare；
S2, each raw material component weighed in S1 is mixed, and is crushed to the particle of 200 mesh；
S3, particle obtained in S2 is added water to cook obtain three times decoct medical fluid, wherein for the first time decoct amount of water be medicine
6 times of material amount decoct 3 hours, and it is 4 times of medicinal material amount that second, which decocts amount of water, decoct 2 hours, third time decocts amount of water
It is 2 times of medicinal material amount, decocts 1 hour, is then combined with and decocts medical fluid three times and the first filtrate is obtained by filtration, the first filter is concentrated under reduced pressure
Relative density at liquid to 75 DEG C is 1.25, obtains the first concentrate；
S4, it is added ethyl alcohol into the first concentrate that S3 is obtained, the percent by volume of ethyl alcohol and the first concentrate is 70%,
Stirring is stood, and the second filtrate is obtained by filtration, and the relative density being concentrated under reduced pressure at filtrate to 80 DEG C is 1.31, obtains the second concentration
Liquid；
S5, auxiliary material sucrose, carboxymethyl cellulose sodium, talcum powder are added into the second concentrate obtained in S4, add water to
Oral solution is made in 1000mL.
Further effect of the invention is illustrated using animal experiment and clinical test below.
One, animal experiment
1, acute toxicity testing
Using NIH mouse 100, SPF grades, half male and half female, weight 18-22g carries out acute toxicity test.Mouse is random
It is divided into two groups, every group 30, i.e. control group and administration group test first fasting 12 hours；It prepared by the embodiment of the present invention 1 treated
The granule of the Chinese medicine composition of Cardiological coronary heart disease is dissolved in water, and (concentration is 6g crude drug/mL, maximum concentration) stomach-filling fills
Stomach volume is 5mL/kg (i.e. unit dosage form is 30g crude drug/kg), and control group gives same amount of normal saline, administration 2 in one day
It is secondary, it delivery time 6 hours, is observed continuously after administration 14 days, and record the toxic reaction and death toll of mouse.
The results showed that compared with the control group, mouse has no notable difference after administration, experiment is observed continuously one month,
Mouse systemic situation, diet, drinking-water, body weight increase are normal；The Mouse oral stomach-filling present invention treats weakness of the spleen and the stomach tablet
LD50 > 30g crude drug/kg, daily maximum dosage-feeding are 60g crude drug/kg/ days.Chinese medicine composition prepared by the embodiment of the present invention 1
Clinical dosage is 12g crude drug/day/people, and for adult weight in terms of 60kg, average dosage is 0.2g crude drug/kg/ days.Press body
Restatement: 300 times as quantity of the dosis tolerata of mouse (average weight is counted using 20g) oral administration gavage Chinese materia medica preparation of the invention.
Therefore Chinese materia medica preparation acute toxicity of the invention is low, clinical application safety.
2, long term toxicity test
The Chinese herbal granules of Cardiological coronary heart disease prepared by the embodiment of the present invention 1 press 12g and 180g raw medicinal herbs/kg to rat
Rat is observed after continuous use 10 weeks (1.0mL/100g weight, 1 time a day) and drug withdrawal 4 weeks, is detected.
The results showed that the hair of anti-tumor Chinese medicine granules of rats, behavior, big prepared by the embodiment of the present invention 1
The indexs such as urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood lipid all have no significant effect, and internal organs naked eyes are not found
After abnormal variation and histological indications show medication 10 weeks and are discontinued 4 weeks, each internal organs of rat nothing is substantially change.Explanation
Small toxicity after anti-tumor Chinese medicine granules of rats long-term administration prepared by the embodiment of the present invention 1, also without abnormal anti-after drug withdrawal
It answers, application is safe.
Two, clinical trial
1, clinical case
The patients with coronary heart disease made a definite diagnosis is development test object, chooses 60 clinical cases, wherein male 35, women 25
Example, eldest 69 years old, minimum 40 years old, clinical manifestation: chest compression sensation of asphyxia, violent burnt sample pain, pain at bored swollen sense
Often be radiated to inside before left shoulder, left arm, when panic attacks, can with collapse, perspiration, worry, be short of breath, palpitaition, nausea or
The symptoms such as dizziness.
2, treatment method
The granule that the embodiment of the present invention 1 is prepared is taken during treating, is respectively taken daily morning and evening once, once 2 bags, one
Bag 3g, treatment cycle are 10 weeks.
3, treatment effectiveness evaluation
Effective: coronary heart disease symptom disappears, and constitution restores normal, recovery from illness；
Improve: the symptom of patient chest pain, uncomfortable in chest, short of breath, palpitaition, collapse, perspiration mitigates, and coronary heart disease symptom is bright
Aobvious to improve, constitution is gradually restored；
It is invalid: improvement standard is not achieved.
4, experimental result
Effective 45 in 60 patients, effective 15, invalid 0, total effective rate is up to 100%.
5, typical case
Chinese medicine composition of the present invention has significant curative effect to coronary heart disease treatment, and case case is as follows:
Example 1, XX, male 65 years old, because suffering from hypertension 3 years, do not improve through multi-treatment, have a headache, dizziness is short of breath, left
Chest paroxysmal pain, is increasingly aggravated, and in September, 2017 because of dizziness headache, it is height through hospital diagnosis that palpitating speed is dynamic then aggravate
Blood pressure, hyperglycemia, hyperlipidemia, coronary heart disease, after in November, 2017 takes granule 2 months of the embodiment of the present invention 1, Huan Zheshen
Body gradually improves, and continues after taking 6 months, and recovery from illness is not recurred, and can do farm work with descending.
Example 2, XX, female, 45 years old, in May, 2018 because of dizziness, there was shouting pain in headache, when left side pareordia, walk it is out of breath plus
Weight, lower limb are ice-cold, are coronary heart disease through hospital diagnosis, after in June, 2018 takes granule one month of the embodiment of the present invention 1,
Sb.'s illness took a favorable turn, and symptom mitigates, and can arrive outdoor activity, continue to take 2 months, can take a walk daily to outside, can do housework work.
Example 3, XX, male, 50 years old, in June, 2018 because of dizziness, out of breath, palpitaition gas was few, lassitude, is through hospital diagnosis
Coronary heart disease, after in July, 2018 takes granule one month of the embodiment of the present invention 1, sb.'s illness took a favorable turn, and each symptom is light and slow,
Continue to be almost recovered after taking half a year, so far without recurrence.
To sum up, Chinese prescription of the present invention is reasonable, at low cost, drug materials are convenient, preparation is simple, short treating period, treatment
Effect is significant, has no toxic side effect.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the Examples 1 to 4 phase of use
Together, it repeats in order to prevent, the present invention describes preferred embodiment, and once a person skilled in the art knows basic wounds
The property made concept, then additional changes and modifications may be made to these embodiments.So the following claims are intended to be interpreted as includes
Preferred embodiment and all change and modification for falling into the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (7)
1. a kind of Chinese medicine composition for treating Cardiological coronary heart disease, which is characterized in that by the raw material components system of following parts by weight
At: 15~20 parts of Radix Angelicae Sinensis, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of safflower, 5~10 parts of rhizoma pinellinae praeparata, 6~12 parts of Clematis kerriana Drumm. Et Craiab, the dried immature fruit of citron orange 5~
10 parts, 3~8 parts of snakegourd, 3~8 parts of Longstamen Onion Bulb, 2~6 parts of Herba Siegesbeckiae, 2~6 parts of caulis lonicerae.
2. the Chinese medicine composition for the treatment of Cardiological coronary heart disease according to claim 1, which is characterized in that by following parts by weight
Several raw material components are made: 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, 15 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 10 parts of Clematis kerriana Drumm. Et Craiab, 5 parts of the dried immature fruit of citron orange, Chinese juniper
3 parts of building, 3 parts of Longstamen Onion Bulb, 2 parts of Herba Siegesbeckiae, 5 parts of caulis lonicerae.
3. the Chinese medicine composition for the treatment of Cardiological coronary heart disease according to claim 1, which is characterized in that by following parts by weight
Several raw material components are made: 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiong, 10 parts of safflower, 10 parts of rhizoma pinellinae praeparata, 6 parts of Clematis kerriana Drumm. Et Craiab, 8 parts of the dried immature fruit of citron orange, snakegourd
8 parts, 8 parts of Longstamen Onion Bulb, 2 parts of Herba Siegesbeckiae, 6 parts of caulis lonicerae.
4. the preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease according to claim 1, which is characterized in that packet
Include following steps:
S1,15~20 parts of Radix Angelicae Sinensis, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of safflower, rhizoma pinellinae praeparata 5~10 are weighed respectively in parts by weight
Part, 6~12 parts of Clematis kerriana Drumm. Et Craiab, 5~10 parts of the dried immature fruit of citron orange, 3~8 parts of snakegourd, 3~8 parts of Longstamen Onion Bulb, 2~6 parts of Herba Siegesbeckiae, 2~6 parts of caulis lonicerae,
It is spare；
S2, each raw material component weighed in S1 is mixed, and is crushed to the particle of 100 mesh or more；
S3, it particle obtained in S2 is added water to cook obtains decocting medical fluid three times, merge and decoct medical fluid three times and be obtained by filtration the
One filtrate, the relative density being concentrated under reduced pressure at the first filtrate to 65~80 DEG C are 1.12~1.28, obtain the first concentrate；
S4, ethyl alcohol is added into the first concentrate that S3 is obtained, stirs, stand, the second filtrate is obtained by filtration, filtrate is concentrated under reduced pressure
Relative density to 80~95 DEG C is 1.28~1.35, obtains the second concentrate；
S5, into the second concentrate obtained in S4, oral solution, capsule, tablet or granule is made in addition auxiliary material.
5. the preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease according to claim 4, which is characterized in that
In step S3, the first time decocts 6~8 times that amount of water is medicinal material amount, decocts 2~4 hours, and second of decoction amount of water is
4~6 times of medicinal material amount decoct 2~3 hours, and third time decocts 2~4 times that amount of water is medicinal material amount, decoct 1~2 hour.
6. the preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease according to claim 4, which is characterized in that
In step S4, the percent by volume of the ethyl alcohol and the first concentrate is 70~75%.
7. the preparation method of the Chinese medicine composition for the treatment of Cardiological coronary heart disease according to claim 4, which is characterized in that
In step S5, the auxiliary material is sucrose, starch, methylcellulose, carboxymethyl cellulose sodium, magnesium stearate, superfine silica gel powder, dodecane
One of base sodium sulphate, hydroxypropyl methyl cellulose, talcum powder or more than one combinations.
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| CN201910143417.6A Pending CN109718319A (en) | 2019-02-26 | 2019-02-26 | A kind of Chinese medicine composition and preparation method thereof for treating Cardiological coronary heart disease |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138577A (en) * | 2013-05-10 | 2014-11-12 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating angina pectoris cold heart-vein type coronary heart disease |
| CN105126034A (en) * | 2015-10-05 | 2015-12-09 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutical preparation for treating coronary heart disease |
| CN108853260A (en) * | 2018-09-17 | 2018-11-23 | 河南科技大学第附属医院 | A kind of drug and preparation method thereof for treating Cardiological coronary heart disease |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138577A (en) * | 2013-05-10 | 2014-11-12 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating angina pectoris cold heart-vein type coronary heart disease |
| CN105126034A (en) * | 2015-10-05 | 2015-12-09 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutical preparation for treating coronary heart disease |
| CN108853260A (en) * | 2018-09-17 | 2018-11-23 | 河南科技大学第附属医院 | A kind of drug and preparation method thereof for treating Cardiological coronary heart disease |
Non-Patent Citations (1)
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| 花继平: "栝楼薤白半夏汤和丹参饮配合西药治疗冠心病心绞痛48例观察", 《安徽中医临床杂志》 * |
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Application publication date: 20190507 |