CN102091181A - Chinese medicinal composition for treating acute and chronic granulocytic leukemia 1 and preparation method thereof - Google Patents

Abstract

The invention provides a Chinese medicine composition for treating acute and chronic granulocytic leukemia 1 and a preparation method thereof. 18 Chinese medicinal herbs including natural indigo, rehmannia root, isatis indigotica fort, turtle shell, papaya, Ningqi medlar, amur corktree bark, American ginseng, astragalus root, radix polygoni multiflori preparata and the like are compounded and prepared into oral capsules according to a proportion. The Chinese medicine composition is salty, sweet, pungent, amaroidal and cold and astrictive, has effects of clearing heat, detoxicating, tonifying Qi, nourishing blood, promoting appetite, relieving uneasiness, reducing a fever, strengthening body resistance to eliminate pathogenic factors, inhibiting growth of myelomonocytic granular cells and white blood cells, reversing sick cell functions to be normal, conditioning to balance a blood system, enhancing physical immunity, promoting neogenesis of red blood cells and hemoglobin and promoting rehabilitation, and has no toxic or side effects and a unique treatment effect on acute and chronic granulocytic leukemia. The Chinese medicine composition is orally taken three times a day with five pills each time by an adult after mixed with warm boiled water before meals; and for children, the dosage is slightly decreased according to the age or the quantitative dosage advised by a doctor. The Chinese medicine composition is taken for more than half a year until the international normal value of the blood system is reached and then taken for one month for consolidation preferably. During taking the Chinese medicine composition, following attentions are followed: patients are avoided eating sour, alkali, cholic, pickled, spiced, pungent, hot and high-protein foods; pregnant women are cautious to take the Chinese medicine composition; and the Chinese medicine composition is avoided being used together with Western synthetic hormone drugs.

Description

Treatment by Chinese herbs acute and chronic neutrophilic type leukemia 1 combination and preparation method thereof

Treatment by Chinese herbs acute and chronic neutrophilic type leukemia 1 combination and preparation method thereof:

The present invention relates to leukemic Chinese medicine composition decoct of a kind of treatment acute and chronic neutrophilic type and the capsular method of preparation, belong to the field of Chinese medicines.

Leukemia is one of human important cause of the death, 1,300 ten thousand new cases are arranged global every year approximately, mortality rate is up to more than 95%, cause that various countries gaze at, China is one of district occurred frequently, (according to the director of the Red Cross Society of China, there are every year 4000000 leukaemics to wait for the bone marrow transplantation treatment approximately in China, Shenzhen Zong Ku has 2600 parts of skeletons, had only ten patients to match benefited (selecting from " health of masses newspaper " total the 657th phase) in 2 years, the bone marrow transplantation of doctor trained in Western medicine is difficult to find the pairing of adaptation and will spends several ten ten thousand RMB, and ordinary person can not bear, the total effects for the treatment of leukemia is ground less than 3 percent in the whole world, the poor several households of the ill doctor of one people, the whole world is ground treating leukemia and spent the more than one hundred billion huge fund every year, and is still blank on Drug therapy, the whole world has up to ten million people to be devitalized by leukemia every year, and primary disease is a human anxious difficult problem for the treatment of the merit gram.I think that the whole world grinds treating leukemia incorrect " understanding " and all explore in two big " mistaken ideas ", basic theorem is wrong in all things, things is " being difficult for " success just, doctor trained in Western medicine is ground and controlled is the hereditism, I think and am only shortcut from the zoobiotism developmental research of the traditional Chinese medical science, the traditional Chinese medical science is the biochemical peptide material with living matter " mediate reason " animal pathological changes, biochemical peptide material is the base substance of all things on earth life, therefrom pharmaceutical developments research shortcut is scientific, the traditional Chinese medical science has experienced vicissitudes in thousand, and what do not lean on is to reach a cure, and the characteristic advantage that lengthens one's life arranged, it is two fruits of producing effects of small investment high repayment that Chinese medicine is cured the disease, Chinese medicine is 21 century best to be human object of study of curing the disease, " World Science circle was once foretold: crack the dead password of cancer gene, final beat cancer must be the Chinese traditional Chinese medical science undoubtedly ".The whole world is all unsatisfactory to leukemic various method of treatment effects at present, and it is costly, therefore there is the anxious demand for the treatment of in people to the leukemic medicine of effective treatment, up to now also do not find the report of the relevant present composition, the present invention is through long-term clinical practice and related data, (and participating in the 3rd the intractable leukemia seminar in the whole nation that calendar year 2001 Chinese people liberation is sponsored), analysis and research pathogenesis and condition of illness from hundreds of routine medical records.1, different depth taste functions declines or imbalance are arranged before patient's disease, lack of appetite and aplastic anemia and immunologic function degression are arranged.2, just do not have immunologic function and hemopoietic function after the morbidity, mainly do not have appetite.3, blood system cells function mutation, it mainly is mononuclear cell, lymphocyte and granulocyte, multiple is three types, the mononuclear cell person of exceeding standard 103 examples from 108 routine leukemia, account for about 94.7%, wherein the substate type 51 routine monokaryon person of exceeding standard 49 examples account for about 96.2%, and lymph type 34 routine monokaryons 31 examples that exceed standard account for 90.6%, granulocyte type 23 examples, monokaryon 21 examples that exceed standard account for about 92.3%.It is phagocyte that primary disease is mainly the mixed mutually mutation of monokaryon, lymph, granulocyte, and engulfs erythrocyte, causes the pathological phenomenon of leukoblast rising red blood cell decreased.And low grade fever's difficulty occurs and the main feature that mixes phenomenon such as move back, mainly divide three types: 1, substate type.2, lymph type.3, granulocyte type, three types all have general character and non-general character, therefore, the classification treatment just can reach better effects in the treatment, avoid eighteen incompatible medicaments and nineteen medicaments of mutual restraint with Chinese medicine in the combination, medication is in conjunction with the comprehensive therapeutic alliance of the state of an illness, and medication will coordinate to reach the purpose that As the medicine took effect, the symptoms lessened mutually.

The present invention has found the leukemic interior oral compositions of treatment granulocyte type finally, thereby has finished the present invention through long-term clinical and medical record data and research repeatedly.

Another object of the present invention provides leukemic composition decoction of treatment by Chinese herbs acute and chronic neutrophilic type and the capsular method of preparation.

(1) Indigo Naturalis is selected in the present invention's combination for use, and property is salty, and little hardship is cold, goes into Liver Channel.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing is used for heat in blood and sends out speckle, and infantile convulsion is desired skin ulcer." property of medicine opinion " separates children's's infantile malnutrition with fever, becomes thin parasite killing.According to chemical analysis, contain indigo, indirubin, couroupitine A and a large amount of inorganic salts etc.According to pharmacological research, indirubin is to ehrlich carcinoma, multiple zoopery tumors such as watt Ke Shi cancer 256 have inhibitory action, can suppress the synthetic of DNA (deoxyribonucleic acid), the myelocytic leukemia cell is had destruction, and it is multiple normal that the chromosomal distortion of chronic myelocytic leukemia patient sick cell is descended, to Normocellular lymph hepatocyte, the synthetic unrestraint effect of the deoxidation nucleic acid of medullary cell has certain liver protection effect.According to clinical report, with Indigo Naturalis or indirubin treatment chronic myelocytic leukemia curative effect is preferably arranged, with indirubin treatment chronic myelocytic leukemia 314 examples, complete remission rate is 26.1%, total effective rate is 87.3%, effective with indirubin treatment acidophilia leukaemia increase disease, consumption 2-5 restrains powder or takes after mixing it with water and do not make decoct.

(2) the combination Radix Rehmanniae, property is sweet, and little hardship is cold, go into the heart, Liver and kidney warp, clearing away heat and cooling blood are gone into blood part, are used for damp and hot patient and seek part, disease is seen fever of the body, and is thirsty, the red tongue person of falling, YIN nourishing and the production of body fluid promoting, nourishing YIN to relieve dryness is arranged, and the merit of promoting the production of body fluid is used for the epidemic febrile disease later stage, consumption of body fluid by heat, thirsty, constipation, tongue falls and dried person, this product sweet can yin nourishing hemopoietic, be used for the cardiopalmus of deficiency of YIN-blood, regularly intermittent pulse person.Shennong's Herbal master folding falls exhausted wound, by arthralgia due to stagnation of blood, fills out bone marrow, and longue meat removes cold and heat and gathers, eliminating impediment, and clothes are made light of one's life by commiting suicide not old for a long time.Chemical analysis, contain B-sitosterol, catalpol, monosaccharide, aminoacid (as lysine, arginine) etc., according to pharmacological research: can suppress 17-hydroxy-11-dehydrocorticosterone catabolism in liver on the kidney, energy Fructus Citri tangerinae Hangzhoupro, contained Chinese catalpa dexamethasone is to the inhibitory action of interrenal system, can make plasma corticosterone remain on normal level, anti-radiation function is arranged, the platelet decline that the radiation rat is caused can make to go up to accelerate, the white mice cell decline that cyclophosphamide is caused has therapeutical effect, consumption 10-30 gram.

(3) compoboard Cymbidium ensifolium (L.) Sw. root: the property hardship, trembling with fear, go into the heart, kidney, lung meridian, heat-clearing and toxic substances removing, clearing away heat-fire, separate the pestilence poison, is the key medicine of clear excess-fire, and bitter cold is gone into blood part, the branch pyretic toxicity purifies the blood, be used for epidemic febrile disease and go into blood part, the kind shape heat that epidemic febrile disease is gone into blood part, the coma of separating, clearing throat, parotitis, infectious hepatitis etc., band shape herpes, chickenpox, flu influenza, viral pneumonias etc. are according to chemical analysis: contain Acanthaceous indigo, Song Lan, careless Folium Isatidis, polygonum tinctorium ait. etc. and all contain the blue or green glycoside of deciding.Clinical report is used for encephalitis b, infectious hepatitis, and monocytosis, the higher person of clinical practice mononuclear cell has unique therapeutic effect, consumption 20-30 gram.Heavy dose of 40-60 gram.

(4) combination Carapax Trionycis, property salty, be slightly cold, go into liver, kidney channel.The tonifying YIN YANG hyperactivity suppressing is used for hyperactivity of YANG due to deficiency of YIN, consumption of YIN caused by febrile disease, and the disease of stirring-up of pathogenic wind in the interior resulting from deficiency, hard masses softening and resolving, it is hard long-pending to be used for disease Shennong's Herbal Zhu Xin mass in the abdomen such as Gan Pi Zhong Da lumps in the chest and abdomen, and cold and heat remove the painful abdominal mass polyp, and erosion of the vulva hemorrhoid are disliked meat.Chemical analysis: contain animal glue, keratin, iodine matter, vitamin D etc., pharmacological research, this product has the effect that suppresses connective tissue proliferation and improve hemoglobin, consumption 20-30 gram.

(5) combination Fructus Chaenomelis: property acid, tepor, gas perfume (or spice), go into liver, spleen channel, acid, relaxing muscles and tendons and activating QI and blood in the collateral, wet perfume (or spice) dries, stomach function regulating removing dampness, the Shujin that can promote the production of body fluid, the gas perfume (or spice) stomach function regulating of being amusing." Mingyi Bielu " main arthralgia chiefly caused by damp pathogen pathogen, cholera is told down greatly, and convulsion is more than.According to chemical analysis, contain Saponin, organic acid, flavonoid, tannin etc., consumption 6-15 gram.

(6) combination NINGQI: property is sweet puts down, goes into liver, kidney, lung meridian.The YIN nourishing of enriching blood is good at tonifying liver blood, is usually used in the asthenia asthenia of essence and blood, and replenishing vital essence to improve eyesight is usually used in having a dizzy spell due to the asthenia of essence and blood, visual deterioration, diseases such as platycoria, can nourishing the liver and kidney lung benefiting the moon again." book on Chinese herbal medicine is focused " nourishing the essence and strengthening QI, prosperous and powerful vagina according to chemical analysis, contains betanin, carotene, thiamine, riboflavin, Yan acid, ascorbic acid etc.According to pharmacological research, experiment has the promotion immunologic function, strengthen the effect of resistance against diseases, the normal cell hemopoietic function there is facilitation, lipotropy is arranged, irritate the mice that stomach is poisoned carbon tetrachloride, the fatty intrahepatic deposition of slight inhibition is arranged with the lycium barbarum infusion, promote hepatocyte new life's effect, and can prevent the liver dysfunction that carbon tetrachloride causes.Consumption 5-10 gram.Heavy dose of 15-20 gram.

(7) combination Cortex Phellodendri: property hardship, cold, go into kidney, bladder, large intestine channel, eliminating fire and detoxication, heat clearing and damp drying is rushed down the kidney fire, and reducing the asthenic fever is used for the disease of the osteopyrexia and fever of kidney high Sheng of fire or hyperactivity of fire caused by deficiency of YIN.Accumulation of heat in the Shennong's Herbal master the five internal organs the intestines and stomach, jaundice, perianal abscess is rushed down profit, woman's whitish metrorrhagia, negative and positive phagedenoma.According to chemical analysis, contain lobule alkali, a small amount of palmatine, obacunone, Cortex Phellodendri lactone etc., the same Rhizoma Coptidis of this product; fungus is had inhibitory action, platelet is had protective effect, it is broken that it is difficult for, and diuresis is arranged; contained lobule alkali has multiple pharmacological effect, consumption 3-12 gram, heavy dose of available 15-20 gram.

(8) combination import ginseng (U.S. or Canada produce): property is sweet, and little hardship is trembled with fear into the heart, lung, stomach, kidney channel, the QI invigorating pathogenic fire reducing is used for asthenic fire punishment gold, YIN-deficiency of the lung and kidney, impairment of purifying function of the lung has the lung heat clearing pathogenic fire reducing, the effect of supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, be used for the tired tired thirsty of cloudy two parts of calentura gas, the effect of supplementing QI for promoting the production of body fluid is arranged, be usually used in the acute and chronic calentura, the disease of the cloudy violent trauma of gas has the effect of supplementing QI to prevent collapse." Bencao Congxin " tonifying the lung pathogenic fire reducing, last body fluid falls tired tired, empty and the person of lighting a fire is suitable.According to chemical analysis, contain glycoside, be mainly the panaquilon and contain Saponin, a small amount of volatile oil, resin, starch and sugar.Consumption 3-6 gram, heavy dose of available 10 grams.

(9) the combination Radix Astragali: property is sweet, and tepor is gone into spleen, lung meridian, tonifying Qi and lifting yang is used for the disease that deficiency of spleen-QI descends, the spleen is the source of growth and development, and anorexia and loose stool then appears in the lung is concerned with QI of the whole body, deficiency of both the splenic and pulmonary QI, be used for Qi and blood deficiency, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema is used for diabetes Shennong's Herbal master's carbuncle of deficiency of vital energy body fluid deficiency and loses skin ulcer, evacuation of pus pain relieving, leprosy disease, five hemorrhoid scrofula, tonify deficiency, children's's all kinds of diseases and ailments.According to chemical analysis, contain choline, betanin, aminoacid, sucrose, Pu Tao Tang Chuo acid and micro-folic acid.According to pharmacological research, cardiotonic is arranged, can strengthen myocardial contraction, hypotensive effect is arranged, its mechanism is with directly expansion is relevant, diuresis is arranged, and the output of sodium, increase, and reduces urine protein and the effect of pathologic urine protein, the effect of human body immunity improving function is arranged, interferon system there is facilitation, hepatoprotective is arranged in addition, prevent the effect that reduce in the glycogen source.Consumption 10-15 gram, heavy dose of 20-50 gram.

(10) combination Radix Polygoni Multiflori Preparata: property is sweet, bitter, puckery, little wet, goes into liver, kidney channel.Invigorating the liver and kidney, benefiting essence-blood are taken a tonic or nourishing food to build up one's health Kidney-Yinly, are used for the early whitening of beard and hair of yang deficiency insufficiency of blood, vertigo and head dark, the weak person of soreness of the waist and knees, arresting seminal emission, energy reinforcing the kindey to control nocturnal emission, detoxifcation laxation, separate sore, functions of loosening bowel relieving constipation is enriched blood and should be used system to give birth to crow, loosening bowel to relieve constipation Radix Polygoni Multiflori, " Kaibao Bencao " controls scrofula, and the pain that disappears is swollen, treats women's head-ornaments wind skin ulcer, controls five hemorrhoid, only pained, replenishing QI and blood, black beard and hair, improving healthy complexion, obey long muscles and bones for a long time, beneficial marrow, it is not old to prolong life, and also controls all diseases of married woman's puerperal and leukorrhagia.According to chemical analysis, contain the anthrone class, main is chrysophanol, emodin, less important is rhababerone, starch, crude fat and lecithin etc.According to pharmacological research, the intestinal tube of promotion creeping effect is arranged, the merit of relieving constipation is arranged, strong mentation is arranged, there is the overslaugh cholesterol in liver, to reach sedimentary effect in the blood vessel, thus the atherosclerosis of slowing down effect is arranged, and the effect of rising blood glucose source is arranged.The clinical report tablet has obvious effect to reducing serum cholesterol, consumption 10-30 gram.

(11) the combination Radix Paeoniae Alba: property hardship, acid, be slightly cold, go into liver, spleen, warp, suppressing liver-YANG can be let out liver-fire, holds back the come-up yang-energy, the yin fluid astringing that nourishes blood, deficiency of YIN deficiency, deficiency of YIN-blood, anemia person, menoxenia etc., easing the affected liver to relieve pain, the breast that is used for transverse invasion of hyperactive liver-QI or incoordination between the liver and stomach is coerced epigastric pain, dysentery stomachache." society's farming book on Chinese herbal medicine warp " main pathogen stomachache is removed arthralgia due to stagnation of blood, broken hard amassing, and cold and heat, hernia purplish or white patches on the skin, pain relieving diuresis QI invigorating according to chemical analysis, contain paeoniflorin, paeonol, paeoniflorin, volatilization wet goods.According to pharmacological research, paeoniflorin has calmness, analgesia, antiinflammatory and alleviates the effect of smooth muscle spasm, the animal stress ulcer there is preventive effect, can expands the strong blood vessel of hat, Acute Myocardial Ischemia in Rats due to the antagonism pituitrin, can expand peripheral blood vessel for the dog intravenous injection, liver protection effect is arranged, and pair cell immunity and humoral immunization have certain facilitation, and Aspergillus flavus is have Detoxication, consumption 6-15 gram, heavy dose of 20-30 gram.

(12) combination gypsum: property is sweet, hot, cold, goes into lung, stomach warp.Clearing away heat-fire, relieving restlessness is quenched the thirst, and is used for damp and hot pain, and heat is at edema caused by disorder of QI, high fever, excessive thirst sweating, the arteries and veins flood, the excess-heat disease of red tongue with yellow fur has the merit of promoting the production of body fluid, the acrid in the mouth expelling pathogenic factors from the exterior that can loose is gone out, thus pathogenic heat that can lung heat clearing stomach warp, the key medicine of dividing excess-heat for the lung heat clearing gastric qi, to epidemic febrile disease, the pyretic toxicity dermexanthesis, but clearing away heat-fire again expelling pathogenic factors from the exterior go out and the pathogenic heat Shennong's Herbal master apoplexy cold and heat heart subinverse gas of clearing heat in QI system branch, the xerostomia scorching tongue, the hardness and fullness in the abdomen pain is by evil ghost, the galactopoiesis incised wound, according to chemical analysis, moisture sulfur calcium (CSO ₄-2H ₂O) sulfide and trace iron, magnesium etc.According to pharmacological research, this product is to suppress the hyperfunction of thermotaxic centre and the stronger refrigeration function of generation.Simultaneously the antiperspirant maincenter also is suppressed, thus analgesic and not diaphoresis, the fraud of no impairment of body fluid, some becomes soluble-salt, is absorbed into blood at small intestinal, and calcium can suppress nervimuscular irritability and play calm, the painful effect in town, can lower vascular permeability, consumption 10-30 gram, heavy dose of 60-100 gram.

(13) combination Herba Taxilli: property is sweet, bitter, flat, goes into liver, kidney channel.Tonifying liver and kidney and strengthening bones and muscles, the wind-damp dispelling pain relieving, nourishing blood and preventing abortion is used for deficiency of the liver and kindey, the essence and blood loss, a little less than the waist knee joint muscles and bones flaccidity, QI invigorating fetus nourishing, articular instability apathy, the solid feotus vitality of the kidney invigorating.Shennong's Herbal master lumbago, children's's stiffback, pain be swollen, antiabortive, fill skin sends out tooth, grows the man.According to chemical analysis ， Han Quercetin and avicularin etc., Herba Taxilli element, leaf contains neat fruit acid, B-face cream alcohol, the meso alcohol stewed, flavone compound etc., according to pharmacological research, blood pressure lowering is arranged, suppress skeleton poliovirus and other enterovirus, effect Bai Guo Herba Visci such as diuresis have the heart tonifying hypotensive effect, and Hong Guo Herba Visci has the heart tonifying diuresis, consumption 10-30 gram.

(14) combination Haematitum: property hardship, cold, go into liver, pericardium, stomach, kidney, warp, suppressing the hyperactive liver and subsiding YANG, tranquillizing and allaying excitement, the important city sending down the abnormal ascending QI, cooling blood for hemostasis is used for excessive rising of liver-YANG, and dizzy order expands, tinnitus Xiao Epilepsy epilepsy, the Yi gas of adverse rising of stomach-QI, vomiting, singultus, hemorrhage etc. due to the heat in blood disease.Shennong's Herbal master tuberculosis, kills smart thing evil spirit at harmful wind handleless cup poison, abdomen poisoning pathogen, and the woman is red to irrigate.Chemical analysis, trioxygen-containingization two ferrum are mixed with foreign material such as being stained with soil, peptide, magnesium, aluminum, silicon, arsenic, according to pharmacological research, sedation are arranged, and can promote the new life of erythrocyte and hemoglobin, consumption 10-30 gram.

(15) combination Radix Gentianae: property hardship, cold, go into liver, gallbladder, urinary bladder channel.Liver heat removing gallbladder excess-fire, damp-heat in lower-JIAO, liver-fire causes conjunctival congestion and swelling pain, diseases such as deafness, otopyosis, scrotum swell and ache, jaundice, pudendal pruritus leucorrhea, eczema.Cold and heat, infantile convulsion pathogen between Shennong's Herbal master bone, continuous exhausted the wound, fixed five will are killed the handleless cup poison, obey Fructus Alpiniae Oxyphyllae for a long time and do not forget, and it is not old to make light of one's life by commiting suicide.According to chemical analysis, contain gentiopicrin, erythricine, Radix Gentianae pigment, Radix Gentianae sugar etc.According to pharmacological research, can promote gastric secretion, free acid is increased, can make stomachic at taking medicine before meal, antiinflammatory hepatoprotective choleretic effect is arranged, the phagocytic function of inflammatory cell there is facilitation.The diuresis hypotensive effect is arranged, and to record pus bacillus, Bacillus typhi and gold-coloured staphylococci etc. has certain inhibitory action, and the damp-heat type infectious hepatitis is had the transaminase lowering effect, consumption 3-10 gram, heavy dose of 20-30 gram.

(16) combination Fructus Jujubae: property is sweet, flat, matter is moistened many liquid, goes into spleen, stomach warp, air making-up and spleen enlivening, nourishing blood to tranquillize the mind, relaxes the property of medicine, and the effect of invigorating the spleen and replenishing QI is arranged, and is used for gas and does not transport, taste, weakness, anorexia and loose stool, blood deficiency, shallow complexion, palpitation and insomnia, protection healthy energy.Shennong's Herbal master trusted subordinate pathogen, regulating the spleen and stomach is supported spleen, helps 12 warps, flat gastric qi, logical nine orifices is mended weak breath, and few body fluid is not enough, frightened in the body, heaviness of limbs and hundred medicines.According to chemical analysis, contain protein, fat, saccharide, calcium, phosphorus, ferrum and vitamin A, B, C etc.According to pharmacological research, the effect of the liver protecting, muscle strength reinforcing and weight increase is arranged, the effect that reduces acute, chronic hepatitis, liver cirrhosis, patients serum's glutamate pyruvate transaminase is arranged, consumption 10-30 gram.

(17) combination Calculus Bovis: property, hardship, sweet, cool, gas is fragrant, goes into the heart, Liver Channel, eliminate phlegm for resuscitation; dispelling wind and relieving convulsion, heat-clearing and toxic substances removing is good at clearing away heart-fire and eliminating phlegm; be used for closing in the epidemic febrile disease expectorant heat coma proverb of pericardium, the disease expectorant of rale apoplexy is stopped up, conscience is hot or faint from fear tic and infantile convulsion etc.Laryngopharynx swelling and pain, " wishing farming book on Chinese herbal medicine warp " main frightened carbuncle cold and heat such as pain pyogenic infections from tumour or sore, intenseness of heat Kuang Chi removes the evil ghost that pursues.According to chemical analysis, contain bilirubin, biliverdin, free bile acid (as cholic acid, chenodeoxycholic acid etc.).Conjugated bile acid (as Calculus Bovis bile salt etc.) heart tonifying material; SMCS; vitamin D calcium, duck, zinc, copper, ferrum, phosphorus etc.; the artificial Calculus Bovis adds starch with cattle and sheep bile acid, hyocholic acid, cholesterol, bilirubin and inorganic salt (magnesium sulfate, ferrous sulfate, calcium phosphate) to be mixed and made into; pharmacological research, the contained deoxycholic acid of Calculus Bovis, sodium cholate etc. can suppress leukocyte and move.Calculus Bovis and artificial Calculus Bovis have facilitation to the bone marrow erythropoiesis.Consumption 0.2-0.5 gram.

(18) combination Rhizoma Atractylodis Macrocephalae: the property hardship, sweet, warm, go into spleen, kidney channel, air making-up and spleen enlivening, dampness diuretic, strengthening superficial resistance to stop perspiration, QI invigorating is antiabortive, key medicine for air making-up and spleen enlivening is used for deficiency-weakness of spleen-QI, weak disease, the phlegm retention edema that spleen insufficiency water is wet to stop gathering, oliguria etc., the exterior deficiency spontaneous perspiration has the merit of strengthening superficial resistance to stop perspiration.The dead flesh of Shennong's Herbal main air cold-damp numbness, convulsion, gallbladder, hidroschesis, heat extraction.According to chemical analysis.Contain volatile oil, be mainly atractylone and Rhizoma Atractylodis Macrocephalae lactone, AB also contains mcg vitamin A.According to pharmacological research, diuresis is arranged.Experimental results show that slight hypoglycemic activity to suppressing renal tubules electrolyte and the re-absorbed result of water, consumption 6-15 gram.

The present invention selects Indigo Naturalis for use through the combination of helping each other; the Radix Rehmanniae; Radix Isatidis; Carapax Trionycis; Fructus Chaenomelis; NINGQI; Cortex Phellodendri; Radix Panacis Quinquefolii; the Radix Astragali; Radix Polygoni Multiflori Preparata; the Radix Paeoniae Alba; Gypsum Fibrosum; Herba Taxilli; Haematitum; Radix Gentianae; Fructus Jujubae; Calculus Bovis; Rhizoma Atractylodis Macrocephalae combination becomes second nature salty; flat; Gan Xin; be slightly cold; bitter; puckery; it is liquor-saturated that chemical analysis contains B-paddy steroid; polysaccharide; aminoacid; keratin; carotene; thiamine; riboflavin; Yan acid; ascorbic acid; lobule alkali; obacunone; the panaquilon; Saponin; the Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) glycoside; choline; betanin; the anthrone class; chrysophanol; emodin; paeoniflorin; H 2 O calcium sulphate Quercetin; iron sesquioxide; gentiin alkaline color element; protein; the red verdazulene of gallbladder; multivitamin etc.; said medicine can be coordinated mutually; without any side effects; heat-clearing and toxic substances removing is arranged; the heat of dispelling is brought down a fever; benefiting qi and nourishing blood; appetite promoting and the spleen strengthening; strengthen appetite; suppress monokaryon and increasement of leucocyte; it is normal to reverse the disease cell function; promote hemoglobin and erythrocyte new life; enhancing human body immunity and hemopoietic function; there is strengthening vital QI to eliminate pathogenic factors to promote the effect of rehabilitation, acute and chronic substate type leukemia is had unique therapeutic effect.

2, decoct method of the present invention; its feature is with mashed in Carapax Trionycis pulverizing, Haematitum, the Gypsum Fibrosum; three flavor medicines add water and were decocted first 30 minutes; after 12 flavor Chinese medicines except that Indigo Naturalis, Calculus Bovis, Radix Panacis Quinquefolii such as the Radix Rehmanniae, Radix Isatidis are pulverized coarser powder and be soaked in water 5 minutes with the three flavor medicines that are decocted first, 25 minutes taking liquid 220 grams that are fried boiling; 20 minutes taking liquid 180 grams are boiled in water; 15 minutes taking liquid 150 grams again are boiled in water; three liquid 550 gram medicinal liquids of boiling medicine were fried in shallow oil the Radix Panacis Quinquefolii fragment 10 minutes; taking liquid 500 grams; divide three bovine calculus powders of taking after mixing it with water, above-mentioned is adult's daily dose.Annotate: the diet acid of taking medicine, alkali, gallbladder, salt down, halogen, suffering, peppery property and high protein food, avoid with Western medicine synthetic hormone medicine and use with.

3, capsule preparation method thereof: its feature 500 after with 2 fried Radix Panacis Quinquefoliis gram medical filtrations concentrate, and drying obtains dry extract and Calculus Bovis mixings porphyrize and spares under the 45-50 degree, and is standby in 15 capsules of packing into.

Claims (3)

1. treatment by Chinese herbs acute and chronic neutrophilic type leukemia 1 combination and preparation method thereof, it is made up of following routine bulk drugs proportioning:

Indigo Naturalis 4 grams, the Radix Rehmanniae 25 grams, Radix Isatidis 3 grams, Carapax Trionycis 30 grams, Fructus Chaenomelis 15 grams, NINGQI 15 grams, Cortex Phellodendri 15 grams, import ginseng 8 grams, the Radix Astragali 30 grams, Radix Polygoni Multiflori Preparata 30 grams, the Radix Paeoniae Alba 20 grams, Gypsum Fibrosum 30 grams, Herba Taxilli 30 grams, Haematitum 30 grams, Radix Gentianae 20 grams, Fructus Jujubae 20 grams, Calculus Bovis 0.5 gram, the Rhizoma Atractylodis Macrocephalae 12 grams.

2. the decocting method of the described compositions of claim 1; its feature is with mashed in Carapax Trionycis, pulverizing Gypsum Fibrosum, the Haematitum; three flavor medicines add water and were fried boiling earlier 30 minutes; after pulverizing coarser powder and be soaked in water 5 minutes with 12 flavor Chinese medicines except that Indigo Naturalis, Calculus Bovis, Radix Panacis Quinquefolii again; three flavor medicines restrain with the 25 minutes taking liquids 220 that are fried boiling with being decocted first; 20 minutes taking liquid 180 grams are boiled in water; be boiled in water again 15 minutes; taking liquid 150 grams; with medicinal liquid 550 grams of being fried in shallow oil for three times 10 minutes taking liquid 500 grams of Radix Panacis Quinquefolii fragment that are fried boiling; divide three take after mixing it with water Indigo Naturalis and bovine calculus powders, above-mentioned is adult's daily dose.

3. prepare the capsule method: claim 2 is described, the 500 gram medical filtrations that its feature is fried in shallow oil compositions, and drying obtains dry cream under the 45-50 degree, and is with dry cream and bovine calculus powder porphyrize, standby in 15 capsules of packing into.