CN103735775A - Traditional Chinese medicine composition for treating iron deficiency anemia - Google Patents
Traditional Chinese medicine composition for treating iron deficiency anemia Download PDFInfo
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- CN103735775A CN103735775A CN201310676198.0A CN201310676198A CN103735775A CN 103735775 A CN103735775 A CN 103735775A CN 201310676198 A CN201310676198 A CN 201310676198A CN 103735775 A CN103735775 A CN 103735775A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating iron deficiency anemia, and belongs to the technical field of traditional Chinese medicine. The composition is prepared from the following raw materials by weight: 20 g of radix codonopsis, 15 g of white peony roots, 20 g of angelica, 20 g of radix rehmanniae preparata, 15 g of medlar, 10 g of donkey-hide gelatin, 15 g of tangerine peel, 15 g of jujube, 20 g of radix astragali, 15 g of poria cocos, 10 g of rhizoma atractylodis, 10 g of ligusticum wallichii, 10 g of rhizoma cyperi, 10 g of schisandra chinensis, 10 g of salvia, 10 g of caulis spatholobi, 10 g of polygala tenuifolia, and 6 g of licorice. The composition of the invention has the effects of tonifying middle-Jiao and replenishing qi, invigorating spleen and tonifying blood, and has significant curative effect on treating iron deficiency anemia.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of iron deficiency anemia.
Background technology
Anemia refers to that human peripheral blood erythrocyte volume is few, lower than a kind of common clinical symptoms of lower limit normal range.Because red blood cell volume mensuration is more complicated, often with hemoglobin (Hb) concentration, replace clinically.China hematologist thinks in area, China sea level, adult male Hb<120g/L, and adult female's (non-gestation) Hb<110g/L, anemia of pregnant woman Hb<100g/L just has anemia.Wherein clinical modal be iron deficiency anemia, it refers in the caused body of a variety of causes stores iron deficiency, finally causes a kind of microcytic hypochromic anemia due to hemoglobin synthesis material deficiency.Clinical manifestation is pale complexion, with dizzy, weak, cardiopalmus, the symptom such as out of breath.
Western medical treatment iron deficiency anemia, normally takes the iron supplement medicaments such as ferrous sulfate, ferrous succinate at present, and simple chalybeate supplements and can only make hemogram recover.Can only improve Anemia.But after drug withdrawal a period of time, often anemia can recur again,
Summary of the invention
The present invention has overcome above-mentioned the deficiencies in the prior art, and a kind of Chinese medicine composition for the treatment of iron deficiency anemia is provided, can invigorating the spleen and replenishing QI, spleen strengthening and blood enriching, improve the adverse effect that primary disease brings patient.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of iron deficiency anemia, it is characterized in that, and by the raw material of following weight, made: 20 grams of Radix Codonopsis, 15 grams of the Radix Paeoniae Albas, 20 grams of Radix Angelicae Sinensis, 20 grams, Radix Rehmanniae Preparata, 15 grams of Fructus Lycii, 10 grams, Colla Corii Asini, 15 grams of Pericarpium Citri Reticulataes, 15 grams, Fructus Jujubae, 20 grams of the Radixs Astragali, 15 grams, Poria, 10 grams of Rhizoma Atractylodis, 10 grams of Rhizoma Chuanxiongs, 10 grams of Rhizoma Cyperis, 10 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes, 10 grams of Caulis Spatholobis, 10 grams of Radix Polygalaes, 6 grams, Radix Glycyrrhizae.
Manufacture method: first by the Impurity removal of each crude drug, all medicines of receiving add 500 milliliters, water in marmite, decocts half an hour, and potion on the one, takes at twice.
Pharmacological action:
Radix Codonopsis: sweet, flat.Start with, meridian of Foot-TAI YIN edema caused by disorder of QI.Invigorating the spleen and replenishing QI, promotes the production of body fluid, and nourishes blood.For the empty asthenia of body of deficiency of QI in middle-JIAO, weakness of the spleen and stomach, deficiency of both QI and blood, controls fatigue and lack of strength, lung qi virtual loss.Control lack of appetite, thirsty, chronic diarrhea, proctoptosis.And the two shallow complexions of losing of QI and blood, dizzy cardiopalmus etc.
The Radix Paeoniae Alba: picric acid is cool.Enter liver, spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant. control the breast abdomen pain over the hypochondriac region, spontaneous sweating, fever due to yin deficiency.
Radix Angelicae Sinensis: sweet, acrid, warm.Enter the heart, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Radix Rehmanniae Preparata: both kind YIN nourishing of enriching blood, again can vital essence replenishing and marrow benifiting, cure mainly the cloudy disease of losing oligospermia of all blood deficiency.Major function nourishing the blood and yin, vital essence replenishing and marrow benifiting, for blood deficiency and yellow complexion, dizzy, cardiopalmus.
Fructus Lycii: have and reduce blood pressure, the effect of blood fat and blood glucose, can prevent arteriosclerosis, the liver protecting, suppresses fatty liver, promotes liver cell regeneration.
Colla Corii Asini: nourishing YIN and supplementing blood, antiabortive.Control blood deficiency, cough due to consumptive disease, spits blood, epistaxis, have blood in stool, and menoxenia, metrorrhagia, vaginal bleeding during pregnancy.
Pericarpium Citri Reticulatae: warm in nature, bitter in the mouth, pungent.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.
Fructus Jujubae: the traditional Chinese medical science thinks, Fructus Jujubae sweet in the mouth, property are flat, can spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, thus make QI and blood abundance, improve the symptoms such as shallow complexion that blood deficiency causes.Modern study also proves, the polysaccharide component in Fructus Jujubae can affect hemopoietic system, promotes hematopoietic function.
The Radix Astragali: warm in nature, sweet in the mouth.Tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, diuretic detumescent.Cure mainly weakness of the spleen and stomach, lack of appetite asthenia, deficiency of vital energy blood prostration, exterior deficiency spontaneous perspiration, night sweat.Modern study finds, the Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and process that can delaying cell aging.
Poria: property is sweet, light, flat, contain fuling enzyme, plant cellulose, glucose, fructose and ashes etc., except breast helps stagnation of QI under the contrary gas heart, controls pain, the wet and taste of cold and heat stuffy sensation with restlessness, cough with dyspnea, diuresis, diuretic, for demulcent, be suitable for palpitation, dysuria, subcutaneous dropsy, sleep disorder disease.
Rhizoma Atractylodis: arduous, temperature.Enter spleen, stomach warp.Spleen invigorating, dampness, resolving depression, wards off dirty.Control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.
Rhizoma Chuanxiong: acrid in the mouth, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma Cyperi: pungent micro-hardship is sweet, flat.Enter liver, tri-jiao channel.The resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.
Fructus Schisandrae Chinensis: acid, temperature.Enter lung, kidney channel, astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung and breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Radix Salviae Miltiorrhizae: hardship, is slightly cold; GUIXIN, Liver Channel.Activating blood circulation to dissipate blood stasis, removing heat from blood mind calming.This product is fallen and promoting the circulation of blood, is apt to into blood system, can qualcomm meridian, change stasis, clearing away heart-fire, removing heat from blood heat, and the will of calming the nerves, tired except throbbing with fear, is usually used in obstruction of qi in the chest and cardialgia, and menstruation portion adjusts, skin infection swells and ache, insomnia and the congestion disease such as swell and ache.
Caulis Spatholobi: bitter, micro-sweet, temperature; Return Liver Channel.Enrich blood and invigorate blood circulation, dredge the meridian passage.This product abnormal smells from the patient is soft, walks to keep and has both, and can change cloudy hemopoietic, promoting the flow of QI-blood by warming the meridian, and promoting blood circulation to remove obstruction in the collateral, pushes away Chen Zhixin, embellishes but not dry, tonify without causing stagnation, row and mend broken feature, to the rheumatic arthralgia due to blood deficiency, all cards of stasis pain and gynecological, all have good effect.
Radix Polygalae: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, resolving depression.Control palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, carbuncle skin ulcer is swollen.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, grows and coughs lung moistening, emergency removing toxic substances, mediation hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.Radix Glycyrrhizae agent has the function of antiinflammatory and resistance state reflection, therefore in doctor trained in Western medicine clinically mainly as demulcent.
In Chinese medicine, without the name of disease of iron deficiency anemia, according to its disease clinical manifestation, can belong to the categories such as " blood deficiency " " sallow " " asthenia ".Chinese medicine is thought, the main blood of the heart, blood stored in the liver, the spleen governs the blood, kidney storing essence, therefore the generation of anemia is relevant to the functional disorder of the heart, spleen, liver, kidney.We are with Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Polygalae tranquilizing by nourishing the heart.The Radix Paeoniae Alba, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Cyperi, Fructus Schisandrae Chinensis, Caulis Spatholobi nourishing the liver and kidney; Radix Rehmanniae Preparata, Poria, Radix Codonopsis, Radix Angelicae Sinensis, Colla Corii Asini, Fructus Jujubae, invigorating the spleen and replenishing QI; The Radix Astragali, Rhizoma Atractylodis spleen strengthening and blood enriching, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicine compatibilities, have the effect of invigorating the spleen and replenishing QI, spleen strengthening and blood enriching, and treatment iron deficiency anemia is evident in efficacy.
The invention has the beneficial effects as follows: Chinese medicine of the present invention is with Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Polygalae tranquilizing by nourishing the heart.The Radix Paeoniae Alba, Rhizoma Chuanxiong, Fructus Lycii, Rhizoma Cyperi, Fructus Schisandrae Chinensis, Caulis Spatholobi nourishing the liver and kidney; Radix Rehmanniae Preparata, Poria, Radix Codonopsis, Radix Angelicae Sinensis, Colla Corii Asini, Fructus Jujubae, invigorating the spleen and replenishing QI; The Radix Astragali, Rhizoma Atractylodis spleen strengthening and blood enriching, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicine compatibilities, have the effect of invigorating the spleen and replenishing QI, spleen strengthening and blood enriching, and treatment iron deficiency anemia is evident in efficacy.
Lower combination clinical data and model case illustrate its therapeutic effect.
One, the clinical effectiveness of Chinese medicine composition of the present invention is described as an example of the clinical data for the treatment of iron deficiency anemia example.
1. clinical data: be selected from and there are the outpatient service of complete data and Patients with iron deficiency anemia totally 72 examples of being in hospital year March in May, 2011 to 2013.Be divided at random two groups, treatment group 80 examples, matched group is 64 examples.Two groups of ages, sex, the course of disease relatively there are no significant difference (P > 0.05), has comparability.
2. diagnosis of iron deficiency anemia standard
(1) the low pigment anemia of minicell: male Hb<120g/L, women Hb<110g/L; MCV<80fl, MCH<26pg, MCHC<0.31; Red cell morphology can have obvious low pigment performance.
(2) have clear and definite Fe deficiency symptoms because of and clinical manifestation.
(3) serum (blood plasma) ferrum <10.7 μ mol/L(60 μ g/L), total iron binding capacity >64.44 μ mol/L(360 μ g/dl).
(4) transferrin saturation <0.15.
(5) bone marrow iron stain shows that bone marrow granule can dye ferrum and disappear, ferrum myelocyte <15%.
(6) free erythrocyte protoporphyrin (FEP) >0.9 μ mol/L(50 μ g/dl) (whole blood), or blood zinc protoporphyrin >0.96 μ mol/L(60 μ g/dl) (whole blood) or FEP/Hb>4.5 μ g/Hb.
(7) serum ferritin (SF) <14 μ g/L.
(8) iron in treatment is effective.Meet any more than 2 articles person in the 1st article and 2~8 articles and can be diagnosed as iron deficiency anemia.
3. Therapeutic Method: treatment group is taken the present invention and treat the Chinese medicine composition of iron deficiency anemia, every day potion, 30 days was 1 course for the treatment of, took 1 course for the treatment of; The embolium of the oral ferrum of matched group, every day 2 times, treats 1 month.
4. efficacy assessment standard:
Iron deficiency anemia efficacy assessment standard is formulated with reference to < < diagnosis of hematological diseases and criterion of therapeutical effect > >.
Clinical recovery: male >120g/I, female 1O5g/I. clinical symptom disappearance, it is normal that serum levels of iron, total iron binding capacity etc. are recovered;
Effective: clinical symptoms is clearly better, anemia Severity gradation is transferred to slightly by severe, improves more than 2 grades;
Effective: symptom takes a turn for the better, anemia severity improves 1 grade;
Invalid: clinical symptoms and anemia Severity gradation are without improvement.
5. therapeutic outcome: two groups of therapeutic outcomes are as shown in table 1:
Table 1 liang group cure rate synopsis
Group | Example time | Recovery from illness/example | Effective/example | Effectively/example | Invalid/example | Total effective rate (%) |
Treatment group | 80 | 62 | 10 | 6 | 2 | 97.5 |
Matched group | 64 | 24 | 10 | 14 | 16 | 75 |
Through check, treatment group and the comparison of matched group total effective rate, difference has very significant (P < 0.001), and has no side effect through this medicine of clinical observation.
Utilize the present invention to treat traditional Chinese medicine composition for treating patient's 80 examples of iron deficiency anemia, result is cured 62 examples, effective 10 examples, and effective 6 examples, total effective rate, up to 97.5%, far above the total effective rate of matched group 75%, and has no side effect.
Model case
Example 1: Liu, man, 38 years old.Patient's face jaundice, weak all over, cardiopalmus, breathe hard, uncomfortable in chest, at conventional hemoglobin (Hb) the 72g/L(normal value 120~160g/L that has a blood test of hospital), be diagnosed as anemia, takes the Western medicine medicament symptom of enriching blood and alleviate, but after drug withdrawal, symptom recurs.By taking Drug therapy of the present invention less than first quarter moon, the state of an illness is clearly better, continue to take medicine a course for the treatment of, and the conventional hemoglobin of having a blood test (Hb) 125g/L.
Example 2: Wang, female, 32 years old.Patient is too much through blood volume for many years, recently finds pale complexion, weak, and dizziness is carried out 7.8 grams of routine blood test blood test Lactoferrins in hospital, takes after western medicine a period of time DeGrain.By taking after three courses for the treatment of of Drug therapy of the present invention, weak, dizzy transference cure, eumenorrhea, check routine blood test: 12 grams of hemoglobin.Follow up a case by regular visits to and within 6 months, have no recurrence.
The specific embodiment
Embodiment 1:
Treat a Chinese medicine composition for iron deficiency anemia, by the raw material of following weight, made: 20 grams of Radix Codonopsis, 15 grams of the Radix Paeoniae Albas, 20 grams of Radix Angelicae Sinensis, 20 grams, Radix Rehmanniae Preparata, 15 grams of Fructus Lycii, 10 grams, Colla Corii Asini, 15 grams of Pericarpium Citri Reticulataes, 15 grams, Fructus Jujubae, 20 grams of the Radixs Astragali, 15 grams, Poria, 10 grams of Rhizoma Atractylodis, 10 grams of Rhizoma Chuanxiongs, 10 grams of Rhizoma Cyperis, 10 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes, 10 grams of Caulis Spatholobis, 10 grams of Radix Polygalaes, 6 grams, Radix Glycyrrhizae.
Manufacture method: first by the Impurity removal of each crude drug, all medicines of receiving add 500 milliliters, water in marmite, decocts half an hour, and potion on the one, takes at twice.
Claims (1)
1. a Chinese medicine composition for the treatment of iron deficiency anemia, is characterized in that, by the raw material of following weight, is made: 20 grams of Radix Codonopsis, 15 grams of the Radix Paeoniae Albas, 20 grams of Radix Angelicae Sinensis, 20 grams, Radix Rehmanniae Preparata, 15 grams of Fructus Lycii, 10 grams, Colla Corii Asini, 15 grams of Pericarpium Citri Reticulataes, 15 grams, Fructus Jujubae, 20 grams of the Radixs Astragali, 15 grams, Poria, 10 grams of Rhizoma Atractylodis, 10 grams of Rhizoma Chuanxiongs, 10 grams of Rhizoma Cyperis, 10 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes, 10 grams of Caulis Spatholobis, 10 grams of Radix Polygalaes, 6 grams, Radix Glycyrrhizae.
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104398789A (en) * | 2014-12-09 | 2015-03-11 | 袁国防 | Traditional Chinese medicine decoction for treating iron-deficiency anemia |
CN104435713A (en) * | 2014-12-10 | 2015-03-25 | 广东聚智诚科技有限公司 | Application of pharmaceutical composition in preparation of medicine for treating anemia |
CN104840598A (en) * | 2015-05-27 | 2015-08-19 | 湖南中医药大学 | Chinese herbal medicine hematinic ointment and preparation method thereof |
WO2016037424A1 (en) * | 2014-09-12 | 2016-03-17 | 梁英珍 | Medicinal liquor for treating irregular menstruation and preparation method therefor |
CN105663483A (en) * | 2016-03-30 | 2016-06-15 | 陈彬 | Traditional Chinese medicine composition for treating parasitic malnutrition type iron deficiency anemia and preparation method thereof |
CN105726754A (en) * | 2016-03-31 | 2016-07-06 | 广州暨南生物医药研究开发基地有限公司 | Folium artemisiae argyi containing traditional Chinese medicine composition for treating hemorrhagic shock and preparation method thereof |
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2013
- 2013-12-12 CN CN201310676198.0A patent/CN103735775A/en active Pending
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宋从有 等: "缺铁性贫血证治浅谈", 《吉林中医药》 * |
杨秀清: "补脾益肾法治疗缺铁性贫血85例", 《陕西中医》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2016037424A1 (en) * | 2014-09-12 | 2016-03-17 | 梁英珍 | Medicinal liquor for treating irregular menstruation and preparation method therefor |
CN104398789A (en) * | 2014-12-09 | 2015-03-11 | 袁国防 | Traditional Chinese medicine decoction for treating iron-deficiency anemia |
CN104435713A (en) * | 2014-12-10 | 2015-03-25 | 广东聚智诚科技有限公司 | Application of pharmaceutical composition in preparation of medicine for treating anemia |
CN104840598A (en) * | 2015-05-27 | 2015-08-19 | 湖南中医药大学 | Chinese herbal medicine hematinic ointment and preparation method thereof |
CN105663483A (en) * | 2016-03-30 | 2016-06-15 | 陈彬 | Traditional Chinese medicine composition for treating parasitic malnutrition type iron deficiency anemia and preparation method thereof |
CN105726754A (en) * | 2016-03-31 | 2016-07-06 | 广州暨南生物医药研究开发基地有限公司 | Folium artemisiae argyi containing traditional Chinese medicine composition for treating hemorrhagic shock and preparation method thereof |
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Application publication date: 20140423 |