CN102362929B - Chinese medicinal composition and extract for treating cancer ischemia, and preparation method and formulation of Chinese medicinal extract - Google Patents
Chinese medicinal composition and extract for treating cancer ischemia, and preparation method and formulation of Chinese medicinal extract Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition and a Chinese medicinal extract for treating cancer ischemia, and a preparation method and a formulation of the Chinese medicinal extract, and belongs to the technical field of Chinese medicinal preparations and preparation methods thereof. The Chinese medicinal composition consists of ginseng, corn cervi pantotrichum, astragalus, bighead atractylodes rhizome, angelica sinensis, rehmannia glutinosa, raw tuber of multiflower knotweed, eucommia, epimedium herb, dragon bone, tortoise plastron, coptis chinensis, divaricate saposhnikovia root, white paeony root, Chinese wolfberry, Chinese date and liquorice. The Chinese medicinal extract is prepared by the following steps of decocting the Chinese medicinal composition in water, and filtering to obtain a water solution. The Chinese medicinal composition and extract have the effects of tonifying Qi, heart, liver, spleen, lung, kidney and bone, and enriching blood, and can strengthen a hematopoietic function of kidney essence.
Description
Technical field
The invention belongs to Chinese medicine preparation and preparation method thereof technical field, is a kind of Chinese medicine composition for the treatment of the cancer ischemia, Chinese medicine extract and preparation method thereof and dosage form specifically.
Background technology
Cancer is a kind of disease of body tissue pathological changes.Cancerous cell and normal cell are inharmonious, and immune metabolism is not harmonious, because normal cell has been embezzled in the growth of cancerous cell several times.At the cancer patient middle and advanced stage, seriously caused the weakness of healthy energy, make cancerous cell and normal cell lose balance, allow health is capable to become inclined to one side Sheng to decline partially, cancerous cell has been defeated normal cell, so, must set upright gas, the nutrient blood of human body deficiency is mended.Defeat cancerous cell.Allow the healthy energy internal memory, heresy can not be done.When enriching blood, with the method for comprehensively enriching blood.Replenish the heart, liver, spleen, lung, kidney, bone.Particularly strengthen the hemopoietic function of kidney essense.Very strong hemopoietic function has been arranged, premunition has just been arranged.Finish jointly so the main method for the treatment of in the treatment cancer is (1), regulate body and (2), set upright hemopoietic.
And the modern doctor trained in Western medicine method of enriching blood is blood transfusion, aminoacid, and blood circulation around being used for, effective during blood transfusion, but owing to lack hemopoietic function in the patient body, so body is also empty after the drug withdrawal, this kind invention has been filled up and has been enriched blood and the weakness of not hemopoietic.
Summary of the invention
For solve the method for enriching blood at present only enrich blood can not hemopoietic problem, at (2) individual aspect of the main method for the treatment of of treatment cancer: set upright hemopoietic, the objective of the invention is to disclose a kind of Chinese medicine composition, Chinese medicine extract and dosage form for the treatment of the cancer ischemia.
Another object of the present invention has been to disclose the preparation method of above-mentioned Chinese medicine extract.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine composition for the treatment of the cancer ischemia, wherein, described Chinese medicine composition is made up of following raw medicaments in portion by weight: Radix Ginseng 8-12 part, Cornu Cervi Pantotrichum 2-3 part, Radix Astragali 18-22 part, Rhizoma Atractylodis Macrocephalae 18-22 part, Radix Angelicae Sinensis 40-50 part, Radix Rehmanniae Preparata 18-22 part, Radix Polygoni Multiflori 18-22 part, Cortex Eucommiae 8-12 part, Herba Epimedii 8-12 part, Os Draconis 20-30 part, Carapax et Plastrum Testudinis 20-30 part, Rhizoma Coptidis 3-5 part, Radix Saposhnikoviae 8-12 part, Radix Paeoniae Alba 18-22 part, Fructus Lycii 18-22 part, Fructus Jujubae 10-15 part, Radix Glycyrrhizae 3-5 part.
The described Chinese medicine composition of technique scheme, wherein, the weight portion of described each crude drug is: Radix Ginseng 9-11 part, Cornu Cervi Pantotrichum 2-3 part, Radix Astragali 19-21 part, Rhizoma Atractylodis Macrocephalae 19-21 part, Radix Angelicae Sinensis 43-47 part, Radix Rehmanniae Preparata 19-21 part, Radix Polygoni Multiflori 19-21 part, Cortex Eucommiae 9-11 part, Herba Epimedii 9-11 part, Os Draconis 22-27 part, Carapax et Plastrum Testudinis 22-27 part, Rhizoma Coptidis 3-5 part, Radix Saposhnikoviae 9-11 part, Radix Paeoniae Alba 19-21 part, Fructus Lycii 19-21 part, Fructus Jujubae 12-14 part, Radix Glycyrrhizae 3-5 part.
The described Chinese medicine composition of technique scheme, wherein, the weight portion of described each crude drug is: 10 parts of Radix Ginsengs, 2 parts in Cornu Cervi Pantotrichum, 20 parts of the Radixs Astragali, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 45 parts of Radix Angelicae Sinensis, 20 parts in Radix Rehmanniae Preparata, 20 parts of Radix Polygoni Multifloris, 10 parts of the Cortexs Eucommiae, 10 parts of Herba Epimedii, 25 parts of Os Draconis, 25 parts of Carapax et Plastrum Testudiniss, 4 parts of Rhizoma Coptidis, 10 parts of Radix Saposhnikoviaes, 20 parts of the Radix Paeoniae Albas, 20 parts of Fructus Lyciis, 13 parts in Fructus Jujubae, 4 parts in Radix Glycyrrhizae.
A kind of Chinese medicine extract for the treatment of cancer, wherein, described Chinese medicine extract is by the described Chinese medicine composition preparation of arbitrary technical scheme in the technique scheme.
The preparation method of Chinese medicine extract described in the technique scheme, wherein, described preparation method is with described Chinese medicinal components decocting, invades bubble 30 minutes with cold water, fries in shallow oil 15 minutes for the first time, fries in shallow oil 10 minutes for the second, three time.Potion 3 days, divide 9 times oral.
The dosage form of the Chinese medicine extract preparation described in the technique scheme, wherein, it is made up of the Chinese medicine extract described in the technique scheme and pharmaceutically acceptable carrier, and described dosage form comprises oral liquid, dissolved granule or honey pill agent.
The effect that each crude drug has in the prescription of the present invention is as follows:
(1), Radix Ginseng: property is flat, sweet in the mouth, little hardship, tepor; Return spleen, lung meridian, heart channel; Strongly invigorating primordial QI is arranged, and multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the effect of the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly;
(2), Cornu Cervi Pantotrichum: sweet, the salty in the mouth of property, temperature; Return kidney, Liver Channel; Invigorating kidney-YANG is arranged, mend the effect of marrow, can make hemoglobin increase in the blood;
(3), the Radix Astragali: sweet in the mouth, slightly warm in nature; The energy invigorating the spleen and replenishing QI, tonifying the lung consolidating superficial resistance, inducing diuresis to remove edema; The effect of enriching blood is arranged;
(4), the Rhizoma Atractylodis Macrocephalae: warm in nature, bitter in the mouth, sweet; Return spleen, stomach warp; Have adjust gastrointestinal motility function, antiulcer, protect the liver, effects such as enhancing human body immunity function, anti-stress, enhancing hemopoietic function;
(5), Radix Angelicae Sinensis: warm in nature, sweet in the mouth, suffering; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation; Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores;
(6), Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature; Return liver, kidney channel; The YIN nourishing of enriching blood, the effect of vital essence replenishing and marrow benifiting;
(7), Radix Polygoni Multiflori: for Chinese medicine Radix Polygoni Multiflori direct slicing is used as medicine; Sweet in the mouth, hardship, property is flat; GUIXIN, liver, large intestine channel; The effect that detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation are arranged is usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation;
(8), the Cortex Eucommiae: the little suffering of sweet in the mouth, warm in nature; Invigorating the liver and kidney is arranged, bone and muscle strengthening;
(9), Herba Epimedii: acrid in the mouth, sweet, warm in nature; Return liver, kidney channel; Cure mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling;
(10), Os Draconis: sweet, puckery, be slightly cold.GUIXIN, liver, warp.Effect, suppressing the hyperactive liver and subsiding YANG, tranquillizing and allaying excitement is restrained astringent or styptic treatment for spontaneous sweating.
(11), Carapax et Plastrum Testudinis: (Testudinis shell on the back) salty in the mouth, sweet, cold nature; Return liver, kidney, heart channel; The nourishing kidney YANG hyperactivity suppressing is arranged, replenishing kidney and strengthening bone, the reinforcing the heart of nourishing blood; Be used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat is had a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and the muscles and bones flaccidity is soft, and it is forgetful to have a guilty conscience;
(12), Rhizoma Coptidis: bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, the conjunctival congestion acid regurgitation, the carbuncle furuncle is quenched one's thirst in toothache;
(13), Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Return bladder, liver, spleen channel; Expelling pathogenic wind from the body surface is arranged, the effect that removing dampness to relieve pain, relieving convulsion are jerked surely; Be used for the diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus;
(14), the Radix Paeoniae Alba: bitter in the mouth, acid, cool in nature; Return liver, spleen channel; The suppressing the hyperactive liver pain relieving is arranged, nourishing blood for regulating menstruation, astringing YIN to stop sweating; Be used for dizzy, the hypochondriac pain of headache, stomachache, extremity spasm, blood deficiency and yellow complexion;
(15), Fructus Lycii: sweet in the mouth, property is flat; Return liver, kidney channel; Nourishing the liver and kidney is arranged, the effect of replenishing vital essence to improve eyesight; Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear;
(16), Fructus Jujubae: sweet in the mouth, warm in nature; Return spleen, stomach warp; Invigorating the spleen and replenishing QI is arranged, the effect of nourishing blood to tranquillize the mind; Be used for insufficiency of the spleen lack of appetite, weak loose stool, the married woman liver is dry;
(17), Radix Glycyrrhizae: sweet in the mouth, property is flat; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription; Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, coordinating the actions of various ingredients in a prescription.
Chinese medicine composition of the present invention and extract are enriched blood with QI invigorating, reinforcing the heart, and tonifying liver, spleen reinforcing, tonifying the lung, the kidney invigorating, it is main mending bone, emphasis is the hemopoietic function that increases kidney essense, remedies the nutrition of self with self hemopoietic.Radix Ginseng, Radix Astragali QI invigorating in the side; Add the effect that the Rhizoma Atractylodis Macrocephalae strengthens spleen reinforcing; Adding Radix Angelicae Sinensis enriches blood; Add Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, Fructus Lycii reinforcing the heart, lung, liver, kidney; The Cornu Cervi Pantotrichum effect is strong, and only with the 2-3 gram, the effect of it and Herba Epimedii, the compatible the kidney invigorating essence of the Cortex Eucommiae is strong, share with medicine-feeding, plays with blood and fills up kidney essense, allows the hemopoietic of kidney essense strengthen the effect of the kidney invigorating essence; Os Draconis, Carapax et Plastrum Testudinis have the effect of fine benefit bone, have share the effect of good benefit bone with medicine-feeding; A little less than the cancer patient body constitution, easy catching a cold has added Radix Saposhnikoviae; Add Rhizoma Coptidis, with Radix Paeoniae Alba regulate body temperature; Cancer mainly is that the inclined to one side Sheng of body declines partially, thus add the Radix Paeoniae Alba, Fructus Jujubae, the inclined to one side Sheng that Radix Glycyrrhizae is regulated body declines partially; The Radix Paeoniae Alba in the side, Radix Glycyrrhizae also has good analgesic effect except regulating body.Chinese medicine composition of the present invention and Chinese medicine extract are except in the treatment cancer, beyond the late period body void; Can also treat the internal organs insufficiency of vital energy and blood that various chronic diseases cause, many deficiency syndrome.
All those skilled in the art, in not breaking away from the technical solution of the present invention scope, can be according to the plus-minus principle of the pharmacology of Chinese medical formulae, under the condition that does not break away from the primary symptom of enriching blood, cold according to patient, heat, void, real, suitably the plus-minus ancillary drug reaches the purpose for the treatment of, as: extremity cold adds Ramulus Cinnamomi, and the extremity heating adds Rhizoma Coptidis, abdominal distention can be thickeied fore-telling, Pericarpium Citri Reticulatae etc.But this can only be used for water decoction.It is essential with original prescription of the present invention to produce by batch.
The present invention has following beneficial effect:
Chinese medicine composition of the present invention and extract based on QI invigorating, enrich blood, reinforcing the heart, tonifying liver, spleen reinforcing, tonifying the lung, the kidney invigorating and benefit bone, mainly can increase the hemopoietic function of kidney essense.
The specific embodiment:
For making technical scheme of the present invention be convenient to understand, the present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1:The preparation of Chinese medicine composition:
Radix Ginseng 8g, Cornu Cervi Pantotrichum 2g, Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 18g, Radix Angelicae Sinensis 50g, Radix Rehmanniae Preparata 22g, Radix Polygoni Multiflori 18g, Cortex Eucommiae 12g, Herba Epimedii 12g, Os Draconis 20g, Carapax et Plastrum Testudinis 30g, Rhizoma Coptidis 5g, Radix Saposhnikoviae 8g, Radix Paeoniae Alba 18g, Fructus Lycii 22g, Fructus Jujubae 10g, Radix Glycyrrhizae 3g.
Embodiment 2:The preparation of Chinese medicine composition:
Radix Ginseng 12g, Cornu Cervi Pantotrichum 3g, Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 22g, Radix Angelicae Sinensis 40g, Radix Rehmanniae Preparata 18g, Radix Polygoni Multiflori 22g, Cortex Eucommiae 8g, Herba Epimedii 8g, Os Draconis 20g, Carapax et Plastrum Testudinis 30g, Rhizoma Coptidis 5g, Radix Saposhnikoviae 12g, Radix Paeoniae Alba 22g, Fructus Lycii 18g, Fructus Jujubae 15g, Radix Glycyrrhizae 5g.
Embodiment 3:The preparation of Chinese medicine composition:
Radix Ginseng 10g, Cornu Cervi Pantotrichum 2g, Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Angelicae Sinensis 45g, Radix Rehmanniae Preparata 20g, Radix Polygoni Multiflori 20g, Cortex Eucommiae 10g, Herba Epimedii 10g, Os Draconis 25g, Carapax et Plastrum Testudinis 25g, Rhizoma Coptidis 4g, Radix Saposhnikoviae 10g, Radix Paeoniae Alba 20g, Fructus Lycii 20g, Fructus Jujubae 13g, Radix Glycyrrhizae 4g.
Embodiment 4:The preparation of Chinese medicine extract:
Get the Chinese medicine composition of embodiment 1-3 gained, invaded bubble 30 minutes with cold water earlier, decocting is 3 times then, fries in shallow oil 15 minutes for the first time, and second and third time respectively fried in shallow oil 10 minutes, merges decocting liquid, obtains Chinese medicine extract.
Chinese medicine composition of the present invention or extract should be by our crude drug in whole foot medicine capacities when producing by batch.Make granule with the universal method of this area then, be condensed into oral liquid, honeyed pill, tablet.
Below by the clinical practice case beneficial effect that medicine of the present invention has is described, this actual case is the clinical observation on the therapeutic effect of medicine of the present invention.(cancer patient all is to be as the criterion with the cut sections for microscopic examination of southwest, Chongqing institute for example.)
1, Zhang, late period cervical cancer.In Chongqing treatment 6 months, radiotherapy, chemotherapy more than 40 time.When coming, neck, the oxter, iliac fossa is metastatic tumor entirely.Dark complexion is thin, in silence, does not have god, lethargy, weak pulse.In May before the treatment cancer, take application number is the Chinese medicine of 201110123144.2 (publication number is CN102198249A) always, and the cancer metastasis tumor obviously disappears.But body nihility power, the people is thin, dark complexion does not have refreshingly, is ischemia symptom, taken medicine of the present invention after, the very fast improvement of health, spirit is worn ruddy more.Speak with a smile.Now fully recover.Two children are with in drug withdrawal 3 months, and Home Alone is done all things.
2, Peng, breast carcinoma, yellowish complexion, anorexia, the lazy speech of breathing hard; Earlier is the Chinese medicinal formulae treatment cancer of 201110123144.2 (publication number is CN102198249A) with application number, the adjusting body, after four doses, the cancer metastasis tumor obviously disappears; Clothes are our again, and behind this side, mouthful stomach of having a meal is good, and muscle is looked very solid, has rosy cheeks, and the mental status is clearly better.
3, grandson, hepatocarcinoma, at cancer mid-term, lassitude, it is bad to sleep, severe palpitation, cardiopalmus, behind this side, spirit is clearly better, and is emotionally stable, and sleeps, not cardiopalmus.
The health that can continue after the case of above-mentioned case is strong after taking medicine of the present invention is exactly because there has been very strong hemopoietic function.The regenerating hematopoiesis that self has been arranged has just had premunition.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any formal and substantial restriction, all those skilled in the art, in not breaking away from the technical solution of the present invention scope, when can utilizing the above technology contents that discloses, and a little change of making, modify the equivalent variations with differentiation, be equivalent embodiment of the present invention; Simultaneously, the change of any equivalent variations that all foundations essence technology of the present invention is done above embodiment, modify and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (6)
1. a Chinese medicine composition for the treatment of the cancer ischemia is characterized in that, described Chinese medicine composition is made up of following raw medicaments in portion by weight: Radix Ginseng 8-12 part, Cornu Cervi Pantotrichum 2-3 part, Radix Astragali 18-22 part, Rhizoma Atractylodis Macrocephalae 18-22 part, Radix Angelicae Sinensis 40-50 part, Radix Rehmanniae Preparata 18-22 part, Radix Polygoni Multiflori 18-22 part, Cortex Eucommiae 8-12 part, Herba Epimedii 8-12 part, Os Draconis 20-30 part, Carapax et Plastrum Testudinis 20-30 part, Rhizoma Coptidis 3-5 part, Radix Saposhnikoviae 8-12 part, Radix Paeoniae Alba 18-22 part, Fructus Lycii 18-22 part, Fructus Jujubae 10-15 part, Radix Glycyrrhizae 3-5 part.
2. Chinese medicine composition according to claim 1 is characterized in that, the weight portion of described each crude drug is: Radix Ginseng 9-11 part, Cornu Cervi Pantotrichum 2-3 part, Radix Astragali 19-21 part, Rhizoma Atractylodis Macrocephalae 19-21 part, Radix Angelicae Sinensis 43-47 part, Radix Rehmanniae Preparata 19-21 part, Radix Polygoni Multiflori 19-21 part, Cortex Eucommiae 9-11 part, Herba Epimedii 9-11 part, Os Draconis 22-27 part, Carapax et Plastrum Testudinis 22-27 part, Rhizoma Coptidis 3-5 part, Radix Saposhnikoviae 9-11 part, Radix Paeoniae Alba 19-21 part, Fructus Lycii 19-21 part, Fructus Jujubae 12-14 part, Radix Glycyrrhizae 3-5 part.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that, the weight portion of described each crude drug is: 10 parts of Radix Ginsengs, 2 parts in Cornu Cervi Pantotrichum, 20 parts of the Radixs Astragali, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts of Radix Angelicae Sinensis, 20 parts in Radix Rehmanniae Preparata, 20 parts of Radix Polygoni Multifloris, 10 parts of the Cortexs Eucommiae, 10 parts of Herba Epimedii, 30 parts of Os Draconis, 30 parts of Carapax et Plastrum Testudiniss, 5 parts of Rhizoma Coptidis, 10 parts of Radix Saposhnikoviaes, 20 parts of the Radix Paeoniae Albas, 20 parts of Fructus Lyciis, 13 parts in Fructus Jujubae, 5 parts in Radix Glycyrrhizae.
4. Chinese medicine extract for the treatment of the cancer ischemia is characterized in that: described Chinese medicine extract is by the described Chinese medicine composition preparation of arbitrary claim among the claim 1-3.
5. the preparation method of the described Chinese medicine extract of claim 4, it is characterized in that: described preparation method is with described Chinese medicinal components decocting, invades bubble 30 minutes with cold water, fries in shallow oil 15 minutes for the first time, fries in shallow oil 10 minutes for the second, three time.
6. the dosage form of the described Chinese medicine extract of claim 4 preparation, it is characterized in that: it is made up of the described Chinese medicine extract of claim 4 and pharmaceutically acceptable carrier, and described dosage form is selected from oral liquid, dissolved granule or honey pill agent.
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| CN1666752A (en) * | 2004-03-08 | 2005-09-14 | 河北恒祥医药集团扁鹊制药有限公司 | Medicine for blood generation and preparing method thereof |
| CN1586575A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Medicine decoction for benifiting qi, tonifying blood and resisting cancer |
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