CN1314422C - Shiweifuzheng medicine for tonifying qi and blood, warning yang and strengthening spleen and its prepn process - Google Patents
Shiweifuzheng medicine for tonifying qi and blood, warning yang and strengthening spleen and its prepn process Download PDFInfo
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Abstract
The present invention relates to a medicine containing ten kinds of traditional Chinese medicines and used for nourishing qi and blood, warning yang and strengthening the spleen and body resistance, and a preparation process thereof. When malignant tumor is treated by modern medicine, different chemotherapeutic medicines are used for chemotherapy but serious poisonous and side effects, such as immunosuppression, bone marrow suppression, etc., of the chemotherapeutic medicines are difficult to prevent, and thus, the therapeutic effect is directly influenced. The medicine is prepared from ginseng, prepared rehmannia rhizome, largehead atractylodesrhizome, astragalus root, indian buead, white paeony root, angelica, cassia bark, liquorice and hemlock parsley. The whole preparation uses the warming products of ginseng, the largehead atractylodesrhizome, the indian buead and the liquorice to nourish qi, and the moistening products of the angelica, the hemlock parsley, the peony root and rehmannia root are used for replenishing blood. If qi is strong, the skeletons grow; if the blood is sufficient, the skeletons are nourished. A body is strong, and the body can not suffer diseases. The preparation has fine match and medicine combination and is used for nourishing qi and blood, warming yang and strengthening the spleen. The present invention is used for leukocytopenia caused by radiotherapy and he chemotherapy of tumor and qi and blood loss caused by immunological function reduction. The present invention has no obvious adverse reaction and is an ideal method for reducing the poisonous and side reaction of radiotherapy and chemotherapy and improving immunity.
Description
One, technical field:
The present invention relates to medicine that a kind of benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors set upright and preparation method thereof.
Two, technical background:
Malignant tumor is sickness rate and all very high disease of case fatality rate after cardiovascular and cerebrovascular disease, is seriously threatening human beings'health.From world wide, it is optimistic that the popularity of tumor is never made us.The data that descriptive epidemiology chief of the office doctor Parkin of IARC (IARC) once accumulated according to them, global tumor invasion example number to various years (1975,1980,1985,1990 and 2000) is estimated, nineteen ninety whole world New Development malignant tumor case number is 8,070,000, than 1975 5,870,000 risen 37.4%, global New Development malignant tumor case number was 1,006 ten thousand in 2000, risen 71.4% than 1975, risen 24.7% than the nineteen ninety.And in this 1,006 ten thousand New Development tumor cases, death reaches 6,200,000.Data shows, early 1990s, it is about 1,300,000 that China dies from the case load of cancer every year, estimates that the morbidity number is about 1,600,000, and the cause of the death constitutes 17.94%, is only second to respiratory system disease, occupies second.China in 1975 has the cancer new cases several 1,210,000, accounts for the whole world and sends out 20.6% of case load, and just about in the world 1/5 cancer patient is in China, to nineteen ninety this numeral rise to 1,390,000.Continued to rise to 1,890,000 to 2000, the ratio that accounts for whole world morbidity sum is 18.8%.China is because the aging gradually of population adds the existence of problems such as smoking, infection, and the situation that treatment and prevention of tumour faced is very severe.
At present, the method for modern medicine treatment malignant tumor mainly contains operation, radiotherapy, chemotherapy, immunization therapy etc.These methods respectively have characteristics, but certain limitation and defective are all arranged.Only adapt to early stage patient as operation and radiotherapy; Medicine and immunization therapy effect are undesirable, and overt toxicity reaction and side effect are arranged; When using multiple chemotherapeutics and carrying out chemotherapy, although can play certain therapeutical effect, but the immunosuppressant of chemotherapeutics, bone marrow depression etc. are serious, toxicity, side effect is difficult to avoid, considerable patient can not tolerate, and causes more excellent chemicotherapy scheme completion rate also to be had only about 70%, causes the chemicotherapy of antitumor can not reach regular dosage schedule or radical-ability dosage, thereby tumor is easy to recurrence and shifts, and directly influences therapeutic effect.Although taked various positive therapeutic measures, the final result of various treatment measures is failure mostly.The Chinese traditional treatment disease is emphasized strengthening the body resistance, reaches the inhibition tumor by the immune system of transferring human body, prolongs patient's life cycle, to remedy these defectives of chemicotherapy.Clinical research confirmation in recent years, Chinese medicine is evident in efficacy definite in the tumor chemoradiotherapy treatment, can effectively reduce or reduce the toxic reaction of chemicotherapy, improve the resistance against diseases of patient's body, improve symptom, prolong survival period, and few side effects, easily accepted, can reach long-term prescription, the purpose of mitigate the disease by the patient.So, Chinese medicine become modern clinical in very important treatment means.
Three, summary of the invention:
The object of the present invention is to provide a kind ofly to be used for that tumor is put, leukopenia caused by cancer chemotherapy, QI and blood is two due to the immunologic function degression loses, and has medicine that benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors set upright and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
The medicine that a kind of benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors are set upright, its special character is the medicament that it is made up of the following weight proportion raw material:
Radix Ginseng 200-300 part Radix Rehmanniae Preparata 200-300 part Rhizoma Atractylodis Macrocephalae 200-300 part
Radix Astragali 200-300 part Poria 200-300 part Radix Paeoniae Alba 200-300 part
Radix Angelicae Sinensis 200-300 part Cortex Cinnamomi 200-300 part Radix Glycyrrhizae 66.48-99.72 part
Rhizoma Chuanxiong 200-300 part
The medicine that above-mentioned a kind of benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors are set upright, wherein the weight proportion of each raw material is:
Radix Ginseng 225-275 part Radix Rehmanniae Preparata 225-275 part Rhizoma Atractylodis Macrocephalae 225-275 part
Radix Astragali 225-275 part Poria 225-275 part Radix Paeoniae Alba 225-275 part
Radix Angelicae Sinensis 225-275 part Cortex Cinnamomi 225-275 part Radix Glycyrrhizae 74.79-91.41 part
Rhizoma Chuanxiong 225-275 part
The medicine that above-mentioned a kind of benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors are set upright, wherein the weight proportion of each raw material is:
250 parts of 250 parts of Rhizoma Atractylodis Macrocephalaes of 250 parts of Radix Rehmanniae Preparata of Radix Ginseng
250 parts of 250 portions of Radix Paeoniae Albas of 250 parts of Poria of the Radix Astragali
83.1 parts in 250 portions of Radix Glycyrrhizaes of 250 portions of Cortex Cinnamomis of Radix Angelicae Sinensis
250 parts of Rhizoma Chuanxiongs
Above-mentioned medicament is the above dosage form of saying of any pharmaceutics.
Above-mentioned medicament is capsule, tablet or oral liquid.
Above-mentioned dosage form is that the processing step of capsular preparation method is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37,80 ℃ of oven dry are pulverized, and add the appropriate amount of auxiliary materials mixing, granulate, and add the volatile oil of step (1) preparation, and facing-up are even, incapsulates, promptly.
Above-mentioned dosage form is that the processing step of preparation method of tablet is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37,80 ℃ of oven dry, pulverize, add the appropriate amount of auxiliary materials mixing, granulate, add the volatile oil of step (1) preparation, and facing-up is even, adds the Pulvis Talci mix homogeneously again, tabletting, coating, promptly.
Above-mentioned dosage form is that the processing step of preparation method of oral liquid is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37;
(3), get sucrose and make syrup, add the clear paste of step (2) preparation, the volatile oil and the antiseptic of step (1) preparation, make oral liquid.
The present invention is with respect to prior art, and its advantage is as follows:
It is definite that the present invention applies to clinical efficacy, has benefiting vital QI and blood, the function of warming YANG and strengthening the spleen.Be used for that tumor is put, leukopenia caused by cancer chemotherapy, QI and blood is two due to the immunologic function degression loses; Disease is seen limbs fatigue, the cardiopalmus of breathing hard, pale complexion, dizziness, inappetence.And not seeing has obvious adverse reaction, be alleviate put, chemotherapy toxic side effect, the ideal method of enhancing immunity.
Four, the specific embodiment:
Motherland's medical science thinks that Different types of etiopathogenises acts on human body, causes that losing of internal organs negative and positive of qi and blood is empty, with the passing of time becomes asthenia again.So according to limbs fatigue, the cardiopalmus of breathing hard, pale complexion, dizziness, the symptom of inappetence, can with put owing to tumor, leukopenia caused by cancer chemotherapy, the two diseases of losing of QI and blood belong to the category of " asthenia " due to the immunologic function degression.After the serious disease, pathogen is crossed Sheng, the visceral-qi damage, and healthy energy is difficult to recover in short-term, with the passing of time forms asthenia.Asthenia is with the difference of disease character, and the negative and positive of qi and blood of loss human body emphasizes particularly on different fields.In conjunction with modern clinical characters, too much with some chemicals or contact harmful substance (as lonizing radiation) excessively, can make cloudy essence and QI and blood impaired, and form the asthenia person.More than the various causes of disease, or cause a disease because of void, due to illness become labor, or due to illness cause void, prolonged deficiency is not answered into labor, and its characteristic of disease, is mainly the deficient of gas, blood, yin, yang.The sick position of decreasing is mainly at the five internal organs, and is dirty even more important with spleen kidney two especially.Forefathers pay attention to the effect of invigorating spleen and kidney in the treatment asthenia.So that The spleen and stomach provide the material basis of the acquired, be source of generating QI and blood, the strong fortune of taste, the vital organs of the human body, extremity bones of the body collectively can be nourished.The kidney being the origin of congenital constitution, and the residence nephroyin and nephroyang is this yuan of life.Pay attention to invigorating spleen and kidney, first the foundation of acquired constitution is unbeaten, then can promote the recovery that each deficiency of five ZANG-organs decreases.According to these characteristics, make benefiting vital QI and blood, the Therapeutic Principle of warming YANG and strengthening the spleen.
Radix Ginseng sweet in the mouth, hardship among the side of the present invention, property is flat, returns spleen, lung, heart channel.The function strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves." herbal classic " thinks that Radix Ginseng can " spasmolytic be throbbed with fear, and removes pathogen, makes eye bright for main tonifying five ZANG-organs, peace spirit, happy Fructus Alpiniae Oxyphyllae." " property of medicine opinion " also have " main the five internal organs QI-insufficiency, five kinds of strain and seven kinds of impairment, deficient thin and weak, tell contrary food down, end the cholera unhappiness sound of vomiting of vomitting, the tonifying five ZANG-organs six internal organs are kept god among the guarantor." record.Zhong Jing is hematonic with the Radix Ginseng, and lid blood is not spontaneous, needs to such an extent that the medicine of yang invigorating gas is living, and sun is given birth to then cloudy long, and blood is prosperous.If the deficiency of YIN is singly enriched blood, blood does not have the mountain and gives birth to, and so depletion of YANG is also.Modern pharmacy studies confirm that Radix Ginseng energy enhancing human body immunity function, prevents that the cell that multiple reason causes from descending.And can strengthen the phagocytic activity of reticuloendothelial system.Can improve the content of healthy human lymphocyte conversion ratio and r-globulin, ISM, thereby improve body's immunity.In addition, Radix Ginseng can improve people's mentality and physical work capacity, to resisting fatigue, improves thinking activities and human body labor efficiency; Can improve old people's brain function, especially attention concentrate and long-time elaborative faculty aspect improvement is arranged; Intelligence, hypomnesis and bradyphrenia there is excitation.Radix Ginseng energy enhancing body is strengthened organism adaptation to the defence capability of destructive stimulus; The low dose of contractility that can improve multiple animal hearts of ginseng infusion, high concentration then weakens heart contractility and decreased heart rate.Radix Ginseng shrinks afterwards earlier blood vessel and expands, and makes vasoconstriction in a small amount, and effect in a large number distends the blood vessels; Blood pressure there is Accommodation; Antishock function is arranged, can make anaphylactic shock and the life span of scald property shock animals such as obviously prolongs at effect.
Radix Rehmanniae Preparata is sweet, and tepor is returned the Liver and kidney warp.The function nourishing YIN and supplementing blood, beneficial essence is filled out marrow.This product tepor Gan Run, quality is grown greasy, and it is the blood of reinforcing the heart liver both, liver nourishing again, the moon of kidney is the key medicine of temperature compensation essence and blood." pearl sac " thinks that Radix Rehmanniae Preparata can " it be empty not enough to enrich blood greatly, promoting blood circulation, physical strength profiting." " detailed outline " also have " fill out bone marrow, longue meat, promoting generation of vital essence and blood, tonifying five ZANG-organs, internal injury deficiency, promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produce all kinds of diseases and ailments." record.Pharmacological evaluation confirms that Radix Rehmanniae Preparata can promote hematopoietic function, raise immunity, blood sugar lowering, inhibition steatolysis, but antiplatelet aggregation also significantly suppresses thrombosis.In addition Radix Rehmanniae Preparata also has effects such as antiinflammatory, blood pressure lowering, calmness, diuresis.
The Rhizoma Atractylodis Macrocephalae is sweet in flavor and warm in property, bitter in the mouth, and the function invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Bitter, sweet, temperature.Return spleen, stomach warp.Materia Medica of Decoction day: " name of the no pale art of book on Chinese herbal medicine is used the Rhizoma Atractylodis Macrocephalae modern times more, controls wind between skin, the hidroschesis painful abdominal mass that disappears ... losslessly then send out, and has antiperspirant then to end, with the same merit of the Radix Astragali "." herbal classic " record Rhizoma Atractylodis Macrocephalae " main air cold-damp numbness, dead flesh, convulsion, cellulitis, hidroschesis, heat extraction disappears tired." the dry and middle QI invigorating of " medicine origin " dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, stomach function regulating, born fluid, main flesh heat, extremity are sleepy, and order is not desired out, tiredness with somnolence, anorexia quenches the thirst, and is antiabortive.Over past ten years to studies show that the Rhizoma Atractylodis Macrocephalae contains volatile oil about 1.5%, wherein main component is atractylol, atractylone.Confirm that the Rhizoma Atractylodis Macrocephalae has strong effect, can make weight increase, exercise tolerance strengthens, and promotes immunologic function.Rhizoma Atractylodis Macrocephalae decoct has diuresis, blood sugar lowering, protects the liver, the blood vessel dilating effect.Rhizoma Atractylodis Macrocephalae oil has calmness, suppresses gastrointestinal peristalsis, antitumor action.In addition, the Rhizoma Atractylodis Macrocephalae has antibiotic, function of increasing leukocyte.
The Radix Astragali is warm in nature, and sweet in the mouth is returned spleen, lung meridian.The tool invigorating QI to consolidate the body surface resistance, the diuresis toxin expelling, the effect of evacuation of pus granulation promoting is important Qi-tonifying drug.Chinese medicine thinks that the Radix Astragali has the effect of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, expelling pus and toxin by strengthening QI, inducing diuresis to remove edema, expelling pus and promoting granulation." not Lu " Yan Qike " it is deficient to mend the husband, the five kinds of over strain weakness and emaciation, stomachache is let out dysentery; Li Yin gas ", " solar corona " meaning " Radix Astragali helps the gas strengthening bone and muscle, puts on flesh and enriches blood ", " pearl sac " record " stomach reinforcing gas; go flesh heat ends spontaneous perspiration, and all pains are used it ", modern pharmacy studies show that the Radix Astragali contains plurality of active ingredients, mainly contains astragalus polysaccharides A, B, C, D, 25 seed amino acids, Radix Astragali saponin first, second, the third, flavonoid, alkaloid, protein, vitamin reaches trace element such as selenium, silicon, cobalt, molybdenum.The Radix Astragali has the enhancing human body immunity function, effects such as heart tonifying blood pressure lowering, blood sugar lowering, diuresis, defying age, resisting fatigue, antitumor, antiviral, calmness, analgesia.The Radix Astragali has obvious facilitation to the antibody systematic function of normal body.The Radix Astragali strengthens the activate the phagocytic capacity of mononuclear phagocyte in humoral immunization, and to somatic cell, natural killer cell discharges immunologic active material, inducement interferon, and many-sides such as interleukin show multiple physiologically active.The T lymphproliferation response that the Radix Astragali can make concanavalin A excite is obvious, and the Radix Astragali has potentiation to the T cell function simultaneously, and the bone-marrow-derived lymphocyte immunologic function is also had tangible potentiation " '.Astragalus decoction has the killing activity that improves NK cells in mice, can strengthen the effects of killing tumor cell indirectly such as cellulotoxic effect of the inductive LAK cell of low dosage IL2.After external use mouse lung macrophage added Radix Astragali extractive solution, its ability of engulfing Staphylococcus albus significantly strengthened.The Radix Astragali has been explained the valuable pharmacological effect of its strengthening vital QI to eliminate pathogenic factors well to the facilitation of immunologic function, has explained the reason of the deficiency syndrome determined curative effect in its treatment infectious disease.It is generally acknowledged that astragalus polysaccharides, aminoacid, alkaloid, flavonoid, glycoside are the effective ingredient of this effect, wherein alkaloid, flavonoid and glycoside composition all have the viricidal effect that directly presses down.It is synthetic that the Radix Astragali and Radix Ginseng all have the DNA that promotes myeloid element; accelerate the level that the nucleated cell splitting action also can improve cyclic nucleotide in the cell; biological regulating system is played a role; the part medicine can stop the increase effect of the non-cancerous cell of medicine (V79 cell) dna single chain interruptions such as 5-Fu, ADM; thereby protected these non-cancerous cell effectively, alleviated the degree that they are killed and wounded by chemotherapeutics.These medicines can strengthen cellular immune function, promote immunomodulating, and enhancing antibody is synthetic.The Radix Astragali is to realize that by the effect of eliminating or weaken suppressor T cell this class medicine has the tumor potentiation of pressing down, and the fit applications chemotherapy has Attenuation.Can also be by activating the phagocytosis of healthy mice macrophage, the transfer of tumor there is certain inhibitory action.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Poria sweet in the mouth strengthening the spleen, the dampness removing spleen invigorating is longer than in promoting diuresis with drugs of tasteless flavour, but the mind tranquilizing and the heart calming of holding concurrently." herbal classic " have " the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and is probably throbbed with fear, the heart is the knot pain down, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis." " not Lu " also have " only quench one's thirst, like to sleep, big abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, edema is drenched knot.Open the breast abdomen, transfer visceral-qi, cut down the kidney heresy, long cloudy, beneficial strength is during guarantor god keeps." record.Poria has immunological enhancement and antitumor action, also has calmness, blood sugar lowering, diuresis, effect such as antibiotic grade.
Radix Angelicae Sinensis is sweet, hot, warm, returns liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation." book on Chinese herbal medicine just " think Radix Angelicae Sinensis " its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, so again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, also the panacea in the blood is also.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable." the modern study discovery: Radix Angelicae Sinensis has anti-platelet aggregation and anti thrombotic action, and can promote hemoglobin and erythrocytic generation, resists myocardial ischemia and the blood vessel dilating effect, and proves that its contained ferulic acid can improve peripheral circulation; In addition, Radix Angelicae Sinensis has the blood fat reducing effect to experimental hyperlipidemia, and non-specific and specific immune function are all had facilitation.The Radix Angelicae Sinensis infusion gives mice oral, can significantly promote hemoglobin and erythropoiesis, this anti-anemia effect.Radix Paeoniae Alba hardship, acid, be slightly cold, return liver, spleen channel.The pain relieving of function suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Radix Paeoniae Alba acid is cold and moisten, and mainly goes into Liver Channel, and the yin fluid astringing that can nourish blood can be had a surplus with it with eliminating pathogen in the liver by the suppressing the hyperactive liver easing the affected liver again with the deficiency of tonifying liver body.So the card of excess of liver-YANG and deficiency of YIN-blood, this product is key medicine." not Lu " claim its can " main clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, stomachache, lumbago ", " Newly Revised Canon of Materia Medica " calls it can " beneficial good blood." paeoniflorin in the experiment confirm Radix Paeoniae has calmness, analgesia, antiinflammatory, effect such as analgesic.
Cortex Cinnamomi suffering, sweet, big heat.Return kidney, spleen, the heart, Liver Channel.It is supporing yang that function is mended fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.The hot sweet big heat of this product, pure sun is dry strong, kind warm in two Jiao and dispersing cold for relieving pain down, red complexion is gone into blood can inspire the QI and blood growth again.So be deficiency of spleen-YANG and kidneyYANG, all pains of cold coagulation, the key medicine of cards such as QI and blood deficiency and coldness." Your Majesty's gas cough with dyspnea, the stagnation of QI sore throat is told suction to " herbal classic " cloud, sharp joint, invigorating the spleen and replenishing QI." " Japan hanako materia medica " think Cortex Cinnamomi " control all pathogenic wind, mend five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit is smart, makes eye bright, warm waist knee joint, broken mass beside the umbilicus note of the ancient Chinese abdominal mass, repercussive blood is controlled migratory arthralgia joint contracture, reuniting the fractured tendons and bones, granulation promoting meat." modern pharmacological research finds that Cortex Cinnamomi has certain leukocyte increasing and anti-radiation function.
The Rhizoma Chuanxiong suffering, temperature.Return liver, gallbladder, pericardium channel.The function blood-activating and qi-promoting, wind-expelling pain-stopping.The hot temperature of loosing of this product is logical, can invigorate blood circulation and can circulation of qi promoting, is the gas medicine in the blood, all pains of all qi depressions to blood stasis, and this product is commonly used.In addition, this product has the merit of wind-expelling pain-stopping concurrently, for controlling the headache key medicine." medicine origin " " is enriched blood, is controlled headache due to deficiency of blood." " " cure mainly secret want " cloud, Rhizoma Chuanxiong its with having four, few positive tying-in one also, main headache two also helps clearly positive three also, dampness four also." " book on Chinese herbal medicine just " " Rhizoma Chuanxiong, its property is kind looses, and walks Liver Channel again, and the blood medicine in the gas is also." discover that Rhizoma Chuanxiong has obvious protective effect to Co60 roentgenization and the formed animal injury of chlormethine, has inhibitory action to the leukaemia.
Motherland's medical science is thought: " people's body, QI and blood.The father of gas person bones of the body collectively, the mother of blood person bones of the body collectively can not make it lose and support the person also." so we according to above theory of Chinese medical science, participate in the people in Radix Rehmanniae Preparata and match, benefiting QI and nourishing blood is monarch drug altogether.The Rhizoma Atractylodis Macrocephalae, Poria spleen invigorating eliminating dampness by diuresis are with the Radix Astragali ginseng QI invigorating spleen reinforcing of helping others; Radix Angelicae Sinensis, the Radix Paeoniae Alba are nourished blood and seek, and help Radix Rehmanniae Preparata to nourish conscience, are ministerial drug.Rhizoma Chuanxiong for the assistant, blood-activating and qi-promoting, make ground, return, the Chinese herbaceous peony tonify without causing stagnation.Cortex Cinnamomi is an adjuvant drug, gets its hot sweet big heat, and pure sun is dry strong, descends two Jiao and dispersing cold for relieving pain in kind the warming up, and red complexion is gone into the meaning that blood can be inspired the QI and blood growth again, with the spleen reinforcing insufficiency of kidney-YANG.Radix Glycyrrhizae Preparata is for making, QI invigorating and in, coordinating the actions of various ingredients in a prescription.
Take a broad view of full side, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, sweet using warming therapy crystalline substance also, so QI invigorating; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae, Radix Rehmanniae, the product of matter profit also, so enrich blood.The prosperous then hundred bones of gas is with dirt, and the prosperous then hundred bones of blood is to support.Body both filled, and then hundred heresies are not gone into, and as seen compatibility is exquisite.All medicines share, and play benefiting vital QI and blood altogether, the merit of warming YANG and strengthening the spleen.
It is definite that the present invention applies to clinical efficacy, has benefiting vital QI and blood, the function of warming YANG and strengthening the spleen.Be used for that tumor is put, leukopenia caused by cancer chemotherapy, QI and blood is two due to the immunologic function degression loses; Disease is seen: limbs fatigue, the cardiopalmus of breathing hard, pale complexion, dizziness, inappetence.And not seeing has obvious adverse reaction, be alleviate put, chemotherapy toxic side effect, the ideal method of enhancing immunity.
Studies have shown that: the present invention's administration after chemotherapy, radiotherapy, spleen and thymic lymphocytes capacity are obviously raise, recover to promote injured immune organ.Observe and confirm: the present invention helps the immunostimulant after chemotherapy of tumors, the radiotherapy, and has no side effect.From January nineteen ninety-five ~ 1996 year December, the tumor patient of immunologic hypofunction after 60 exampleizations, the radiotherapy is treated, obtained curative effect preferably.To 40 examples accept to put, the patient of chemotherapy carries out the present invention and adds and subtracts treatment, the patient is divided into A group (combination radiotherapy group) 20 examples at random, B organizes (chemotherapy group) 20 examples, C organizes (matched group) 20 examples.Observe the bone marrow depression degree of respectively organizing.Result: A, B group leukopenia degree obviously is better than the C group, obviously weakens in C group comparison same period bone marrow inhibition.Confirm that but the present invention's ameliorate tumor patient is put, the toxic action of chemotherapy.In with of the treatment of the present invention's plus-minus to the patients with gastric cancer postoperative chemotherapy, use treatment group patient of the present invention, symptom is compared obviously with matched group and is alleviated.Use the present invention can finish chemotherapy treatment smoothly, reduce chemotherapy toxic side effect.To having 3 routine gynecological cancer patients of dyscrasia tendency to give medicine of the present invention (7.5g/d) and Radix Ginseng Rubra (3g/d), observe the variation of its clinical symptoms and blood test value according to serum albumin and the diagnosis of acetylcholine esterase value.As a result, among the 3 routine patients, have 2 routine appetite to increase, serum albumin and acetylcholine esterase rise, and can further accept chemistry and radiation cure; Not reaction after 1 example is taken medicine, the dyscrasia state continues to worsen.The result shows, medicine of the present invention and Radix Ginseng Rubra have the improvement effect to the dyscrasia tendency according to serum albumin and the judgement of acetylcholine esterase value.The 17 routine patients that carry out maintenance hemodialysis in outpatient service are object, wherein male 11 examples, and women 6 examples, the mean age is 56 years old, protopathy is nephritis person's 11 examples, diabetes 4 examples, polycystic kidney 1 example, tumor of kidney 1 example.Give extract drugs agent 5g of the present invention, oral after morning every day, the supper, took for 8 weeks continuously.Carry out questionnaire survey, result respectively at before and after taking medicine: research is withdrawed from the drug withdrawal midway of 4 examples among the 17 routine patients, and 12 routine astheniies alleviate, and 1 example is invalid, and effective percentage is 71%.Confirm that medicine of the present invention has therapeutical effect to the symptom of this QI and blood deficiency.7 routine esophageal carcinoma patients of chemicotherapy are object before implementing art year October with in March, 1992 ~ 1993.Give extractant of the present invention (7.5g/d, administration group) to 2 routine patients wherein continuously when the treatment beginning, do not give the present invention (non-administration group) all the other 5 examples.Weekly leukocyte count and platelet count are measured after 7 weeks of treatment from the treatment beginning is preceding,, the pelvis disease that chemicotherapy causes is estimated by leukocyte and hematoblastic slip between comparing two groups.As a result, two groups of leukocyte counts are all minimum during week at 5-6, and the tendency of rise is arranged later on.But slip administration group was 73.2% (after 5 weeks), and non-administration group was 55.0% (after 6 weeks), administration group slip height.The variation of platelet count, though same trend is also arranged, its slip is lower slightly.
In order to study the present invention to Immune Effects.Cause the immunosuppressed mice model with cyclophosphamide and hydrogenation Bo Nisong, give the present invention of 100% and 50% respectively and irritate stomach, 0.5ml/ only/d, with SRBC-DTH, ATER, HA and spleen index as detecting index.The result: the present invention of 100% and 50% all can obviously improve the SRBC-DTH level of mice and ATER and all can make spleen heavily reach index and obviously descend, and edema alleviates.Experimentation shows; the present invention can obviously resist the reduction of the SRBC-DTH due to the andrographolide and the reduction of caused by cyclophosphamide immunosuppressed mice serum hemolysin level; and the splenic injury of caused by cyclophosphamide there are significant protection and repair; prompting the present invention can obviously improve the side effect of chemotherapeutics, and can improve the antineoplastic immune power of body.In to research of the present invention, find that each dosage group of the present invention all can improve to encircle WBC, N due to the phosphorus phthalein amine, L decline number notable difference is relatively arranged with cycli phosphate amine group.Proof can obviously improve Hb and RBC content to hemorrhagic anemia; To the inhibitory action of caused by cyclophosphamide mice hemopoietic function, significant protective effect is arranged and excite its proliferation function; And can increase thymus and adrenal gland's weight, blood glucose there is tangible increase effect; Can prolong swimming time and the hypoxia endurance time of mice.Studies confirm that the present invention has the effect of prevention cancer cell metastasis.Testing with mice.Experiment is divided into 2 groups with mice, 6 every group.First group of continuous 1 week gives the present invention, and second group is non-administration matched group.All inject high metastatic carcinoma cell for two groups.The liver of two groups of mices of 3 weeks back observation, 6 mices of matched group all have neoplasm metastasis, liver swelling; And the present invention (40mg) group cancerous cell does not form the bulk tuberosity substantially, and does not see and lose weight and side effect such as depilation.To injecting other 6 mices of high metastatic carcinoma cell, give anticarcinogen along grabbing ammonia platinum, suppress the effect that shifts although have, in 6 mices 3 because of side effect death in 3 weeks.
Cisplatin is a kind of anticarcinogen, and some cancer is had good effect, and the homemade cisplatin of China also is widely used in clinical.But find that cisplatin has serious toxic and side effects, especially the toxicity to kidney is bigger, can cause serum urea nitrogen (BUN), creatinine (Cr), the active rising of lactic acid dehydrogenase (LDH), so limited its clinical practice to a certain extent.The foreign scholar has studied the toxicity mechanism and the prophylactico-therapeutic measures of cisplatin, and obtains certain progress.Can the present invention be to the toxic influence of cisplatin induction in research, simultaneously, observe the present invention and alleviate or prevent the lethal toxicity of cisplatin to mice when high dose.Result: oral 1.7 and the present invention of 3.4g/kg after 12 days, when not influencing the cisplatin active anticancer, sweet concentration increase of blood urea nitrogen, the creatine that cisplatin is caused and glutamic oxaloacetic transaminase, GOT, gpt activity strengthen, and stomach heavily increases all and is suppressed, and leukocyte, platelet counts are reduced, spleen is heavy, thymus heavily reaches dietary amount, the body weight attenuating is suppressed. and 3.4g/kg the present invention can make the time-to-live of mice obviously prolong.The result shows that the present invention can alleviate the clinical toxicity of cisplatin and reduce mortality of mice.With the present invention side of plus-minus the prevention effect of cisplatin nephrotoxicity is observed.Mice to the present invention side of plus-minus has significant reduction effect to serum urea nitrogen, the rising of serum creatinine content and the rising of lactic acid dehydrogenase activity due to the continuous 5d of lumbar injection cisplatin 5mg/kg, (1g crude drug/ml) is best, then is best with 1.0ml to the reduction of lactic acid dehydrogenase with every mice 0.8ml every day to the reduction effect of blood urea nitrogen and creatinine.Confirm that there is tangible preventive and therapeutic effect the present invention side of plus-minus to the injury of kidney due to the cisplatin.
More than full and accurate research data show that the present invention has tangible mutation and antitumor action, thereby the proof treatment by Chinese herbs is blocking-up sudden change and alleviating puts, one of the comparatively ideal method of chemotherapy toxic side effect.Pharmacological research provides abundant theoretical foundation for the present invention's application clinically.
Specific embodiment 1:
Radix Ginseng 250g Radix Rehmanniae Preparata 250g Rhizoma Atractylodis Macrocephalae 250g
Radix Astragali 250g Poria 250g Radix Paeoniae Alba 250g
Radix Angelicae Sinensis 250g Cortex Cinnamomi 250g Radix Glycyrrhizae 83.1g
Rhizoma Chuanxiong 250g
Described dosage form is that the processing step of capsular preparation method is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37,80 ℃ of oven dry are pulverized, and add the appropriate amount of auxiliary materials mixing, granulate, and add the volatile oil of step (1) preparation, and facing-up are even, incapsulates, promptly.
Specific embodiment 2:
Radix Ginseng 200g Radix Rehmanniae Preparata 200g Rhizoma Atractylodis Macrocephalae 200g
Radix Astragali 200g Poria 200g Radix Paeoniae Alba 200g
Radix Angelicae Sinensis 200g Cortex Cinnamomi 200g Radix Glycyrrhizae 66.48g
Rhizoma Chuanxiong 200g
Described dosage form is that the processing step of preparation method of tablet is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37,80 ℃ of oven dry, pulverize, add the appropriate amount of auxiliary materials mixing, granulate, add the volatile oil of step (1) preparation, and facing-up is even, adds the Pulvis Talci mix homogeneously again, tabletting, coating, promptly.
Specific embodiment 3:
Radix Ginseng 300g Radix Rehmanniae Preparata 300g Rhizoma Atractylodis Macrocephalae 300g
Radix Astragali 300g Poria 300g Radix Paeoniae Alba 300g
Radix Angelicae Sinensis 300g Cortex Cinnamomi 300g Radix Glycyrrhizae 99.72g
Rhizoma Chuanxiong 300g
Described dosage form is that the processing step of preparation method of oral liquid is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37;
(3), get sucrose and make syrup, add the clear paste of step (2) preparation, the volatile oil and the antiseptic of step (1) preparation, make oral liquid.
Claims (7)
1, the medicine set upright of a kind of benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors is characterized in that making that described Chinese medicine raw materials of effective components is formed and weight proportion is:
Radix Ginseng 200-300 part Radix Rehmanniae Preparata 200-300 part Rhizoma Atractylodis Macrocephalae 200-300 part
Radix Astragali 200-300 part Poria 200-300 part Radix Paeoniae Alba 200-300 part
Radix Angelicae Sinensis 200-300 part Cortex Cinnamomi 200-300 part Radix Glycyrrhizae 66.48-99.72 part
Rhizoma Chuanxiong 200-300 part
2, the medicine set upright of a kind of benefiting vital QI and blood according to claim 1, warming YANG and strengthening the spleen ten flavors is characterized in that: make that described Chinese medicine raw materials of effective components is formed and weight proportion is:
Radix Ginseng 225-275 part Radix Rehmanniae Preparata 225-275 part Rhizoma Atractylodis Macrocephalae 225-275 part
Radix Astragali 225-275 part Poria 225-275 part Radix Paeoniae Alba 225-275 part
Radix Angelicae Sinensis 225-275 part Cortex Cinnamomi 225-275 part Radix Glycyrrhizae 74.79-91.41 part
Rhizoma Chuanxiong 225-275 part
3, the medicine set upright of a kind of benefiting vital QI and blood according to claim 1, warming YANG and strengthening the spleen ten flavors is characterized in that: make that described Chinese medicine raw materials of effective components is formed and weight proportion is:
250 parts of 250 parts of Rhizoma Atractylodis Macrocephalaes of 250 parts of Radix Rehmanniae Preparata of Radix Ginseng
250 parts of 250 portions of Radix Paeoniae Albas of 250 parts of Poria of the Radix Astragali
83.1 parts in 250 portions of Radix Glycyrrhizaes of 250 portions of Cortex Cinnamomis of Radix Angelicae Sinensis
250 parts of Rhizoma Chuanxiongs
4, the medicine of setting upright according to claim 1 or 2 or 3 described a kind of benefiting vital QI and blood, warming YANG and strengthening the spleen ten flavors, it is characterized in that: described medicament is capsule, tablet or oral liquid.
5, the medicine set upright of a kind of benefiting vital QI and blood according to claim 4, warming YANG and strengthening the spleen ten flavors is characterized in that:
Described dosage form is that the processing step of capsular preparation method is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37,80 ℃ of oven dry are pulverized, and add the appropriate amount of auxiliary materials mixing, granulate, and add the volatile oil of step (1) preparation, and facing-up are even, incapsulates, promptly.
6, the medicine set upright of a kind of benefiting vital QI and blood according to claim 4, warming YANG and strengthening the spleen ten flavors is characterized in that:
Described dosage form is that the processing step of preparation method of tablet is as follows:
(1), Radix Ginseng, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials are decocted with water twice, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37,80 ℃ of oven dry, pulverize, add the appropriate amount of auxiliary materials mixing, granulate, add the volatile oil of step (1) preparation, and facing-up is even, adds the Pulvis Talci mix homogeneously again, tabletting, coating, promptly.
7, the medicine set upright of a kind of benefiting vital QI and blood according to claim 4, warming YANG and strengthening the spleen ten flavors is characterized in that:
Described dosage form is that the processing step of preparation method of oral liquid is as follows:
(1), with Radix Ginseng, Radix Rehmanniae Preparata, decoct with water twice from art, the Radix Astragali, Poria, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Rhizoma Chuanxiong ten flavor medical materials, add 8 times of amounts of water for the first time, add 7 times of amounts of water for the second time, each 2 hours, extract volatile oil simultaneously, standby;
(2), merge twice decocting liquid, filter, filtrate is concentrated in the time of 60 ℃, relative density is the clear paste of 1.34-1.37;
(3), get sucrose and make syrup, add the clear paste of step (2) preparation, the volatile oil and the antiseptic of step (1) preparation, make oral liquid.
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| CN102225182B (en) * | 2011-06-20 | 2012-07-25 | 朱友文 | Traditional Chinese preparation capable of inhibiting tumor and enhancing immunity and preparation method thereof |
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| CN109745444A (en) * | 2017-11-07 | 2019-05-14 | 甘肃省金羚集团药业有限公司 | A kind of Traditional Chinese medicine compound composition for treating deficient qi and blood |
| CN108295145A (en) * | 2018-03-19 | 2018-07-20 | 安徽天缘药业科技有限公司 | A kind of processing method of nourishing and health preserving donkey-hide gelatin |
| CN113332326A (en) * | 2021-06-15 | 2021-09-03 | 张家港市中医医院 | Traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and preparation method thereof |
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| CN1270051A (en) * | 1999-04-12 | 2000-10-18 | 张英才 | Full-of-sap prescription |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1270051A (en) * | 1999-04-12 | 2000-10-18 | 张英才 | Full-of-sap prescription |
Non-Patent Citations (1)
| Title |
|---|
| 国家样品标准新药转正标准 国家药典委员会，11，国家药典委员会 2003 * |
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Assignee: Shaanxi Ark Pharmaceutical Co., Ltd. Assignor: Song Shiwei|Li Zhaoxia Contract record no.: 2011610000017 Denomination of invention: Shiweifuzheng medicine for tonifying qi and blood, warning yang and strengthening spleen and its prepn process Granted publication date: 20070509 License type: Exclusive License Open date: 20051019 Record date: 20110325 |
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