CN102225182B - Traditional Chinese preparation capable of inhibiting tumor and enhancing immunity and preparation method thereof - Google Patents
Traditional Chinese preparation capable of inhibiting tumor and enhancing immunity and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese preparation capable of inhibiting tumor and enhancing immunity and a preparation method thereof. The traditional Chinese preparation comprises the following bulk medicaments in parts by weight: 20-90 parts of ginseng, 30-120 parts of Tuckahoe, 30-120 parts of asreagalus mongholicus, 10-120 parts of Fagopyrum cymosum, 30-120 parts of Chiense angelica, 20-100 parts of Achyranthes bidentata and 30-120 parts of carcuma longa. The preparation method comprises the following steps: 1, washing medicinal materials with water, drying, smashing into medicinal powder with 60-80 meshes, evenly mixing, extracting with ethanol three times, filtrating, concentrating, and drying to obtain an extract; 2, decocting residue twice, and mixing two filtrates so as to obtain an extract; and 3, respectively stirring the extracts obtained in the steps 1 and 2 to be thick paste, drying and smashing into fine powder with 100-200 meshes so as to obtain powder, and adding auxiliaries so as to prepare capsule and the like. The preparation is capable of reinforcing vital energy deficiency, improving immunity, gently taking effect, eliminating evil and restoring menstrual flow and clearing away heat and toxic materials and obviously inhibiting malignant tumor; and after the traditional Chinese preparation is administrated, the health is effectively improved, and life is promoted to be prolonged.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, specifically refer to a kind of Chinese medicine preparation and method for preparing that suppresses tumor and enhancing immunity.
Background technology
Cause the factor of tumor a lot, a major reason is positive QI-insufficiency, and promptly immunologic function reduces.When the body immune system function reduced, body immune system can not promptly and accurately be found the cancerous cell that suddenlys change, and the existence of anticancer, and promptly the institute of heresy gathers.Cause cancerous cell polymerization, fission propagation, i.e. the traditional Chinese medical science said " healthy energy is lost empty, pyretic toxicity pent up ", " stagnation of QI with the passing of time, blood stasis accumulate long-pending " must cause local pathological change, cause canceration to take place.In the life, people's survival pressure is big, environmental pollution increases in modern times, has more increased the environment of " heresy gather ", and the world dies from the malignant tumor number every year to be had and increase trend year by year.Though doctor trained in Western medicine has several different methods on the treatment tumor; As ocal resection again through put, chemotherapy kills the residual cancer cell; But at present through put, during chemotherapeutic treatment the patient not only misery is many, cause more macrolesion of health again, suppressing tumor cell simultaneously; Normal cell has also received grievous injury, and uncertain therapeutic efficacy is fixed.Motherland's medical science is early on the books for the etiology and pathogenesis and the Therapeutic Method of tumor.Be " healthy energy lose empty ", " pathogen occupies therebetween " with regard to the cause of disease of mentioning tumor in " interior warp ".All the vital organs of the human body hold poison and do not flow, and battalion defends is jammed and sends out.QI and blood is popular not normal, and health is empty to be lost, and the institute of heresy gathers, must disorder of movement of QI.The stagnation of QI, the stagnation of QI, gas gather, and with the passing of time become disease, cause water-damp not being transformed, and body fluid is cloth not.With the passing of time heat-transformation, poison are accumulate in interior.Ancients resemble malicious pathogenic heat Sheng when treatment as what malignant tumor was developing.So " strengthening vital QI to eliminate pathogenic factors, heat-clearing and toxic substances removing " is one of fundamentum of treatment tumor.
The tcm product that some treatment tumors are also arranged in the market, how be with eliminating evil main, set upright deficiency because malignant tumor patient immunity of organism balance destroys, the immunoregulation effect disappearance, so it is long to take these tcm product treatment cycle, DeGrain.
Summary of the invention
The object of the present invention is to provide a kind of inhibition tumor cell and enhancing immunity, the Chinese medicine preparation of treating both the principal and the secondary aspects of a disease at the same time, and treatment cycle is short, effect is obvious.Another object of the present invention is to provide the method for preparing of this Chinese medicine preparation,
The objective of the invention is to realize like this, its crude drug and weight proportion are following: 20 ~ 90 parts of Radix Ginsengs, 30 ~ 120 parts in Poria, 30 ~ 120 parts of the Radixs Astragali, 10 ~ 120 parts of Rhizoma Fagopyri Dibotryiss, 30 ~ 120 parts of Radix Angelicae Sinensis, 20 ~ 100 parts of Radix Achyranthis Bidentataes, 30 ~ 120 parts in Rhizoma Curcumae Longae.
Its crude drug and weight proportion are preferably following: 25 ~ 70 parts of Radix Ginsengs, 50 ~ 100 parts in Poria, 50 ~ 100 parts of the Radixs Astragali, 60 ~ 110 parts of Rhizoma Fagopyri Dibotryiss, 50 ~ 100 parts of Radix Angelicae Sinensis, 40 ~ 80 parts of Radix Achyranthis Bidentataes, 60 ~ 110 parts in Rhizoma Curcumae Longae.
Optimum weight proportioning of the present invention is following: 30 parts of Radix Ginsengs, 60 parts in Poria, 60 parts of the Radixs Astragali, 60 parts of Radix Angelicae Sinensis, 60 parts of Radix Achyranthis Bidentataes, 90 parts in Rhizoma Curcumae Longae, 90 parts of Rhizoma Fagopyri Dibotryiss.
In the side, Radix Ginseng, Poria, the Radix Astragali, Radix Angelicae Sinensis, invigorating the spleen and replenishing QI, Radix Achyranthis Bidentatae, Rhizoma Curcumae Longae, Rhizoma Fagopyri Dibotryis, detoxicating and resolving stagnation of pathogens.
Radix Ginseng, all empty holding concurrently transferred, the five internal organs are all mended, do not have through less than, the central nervous system is had regulating action.Inhibition, stable, sedation are arranged.Lymphocyte transformation there is facilitation.Can obviously strengthen spleen and thymus T proliferation of lymphocytes.The ginsenoside can strengthen the tumor-bearing mice natural killer cell activity, suppresses tumor propagation.The ginseng polysaccharide can make normal mouse splenocyte natural killer cell activity obviously strengthen.The ginsenoside Re can make the flowability of inmature and mature erythrocyte film increase, and erythrocyte membrane is had protective effect.Gathering to collagen-induced has inhibitory action.Experiment proof ginsenoside, ginseng polysaccharide and ginseng essential oil all have antitumor action and promote the body cell immunization.Tumor cell had induction propagation suppresses, the inducing apoptosis of tumour cell effect, and can alleviate radiation damage, promote it to recover, thereby reduce the side effect of antineoplastic radiation and chemotherapy.
Poria, GUIXIN spleen lung kidney channel, promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach.Its up born fluid loosing the interspaces of skin and muscles, the source of growing water, the decline diuresis, waterway has the effect of analgesic eliminating stagnation.Pachyman can suppress murine sarcoma S180 and ehrlich carcinoma, improves the mouse interior tumor necrosin level and the activity of natural killer cell of inoculation ehrlich carcinoma, and the DNA of tumor cell is synthesized has tangible irreversible inhibitory action.Poria have obvious enhancing macrophage and produces the ability that induces tumor necrosis factor, and anticarcinogen is had potentiation.Pachyman has obvious raise immunity effect.Strengthen macrophage phagocytic function, make the spleen antibody secreting cell count showed increased, thereby improve people's cellular immune function, make the leukocyte of decline quicken.
The Radix Astragali, benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening has the humoral immunization effect of enhancing and immunization of cell, and natural killer cell (NK cell) activity is had obvious facilitation.Astragalus polysaccharides can make T cell number increase in mouse thymus and the spleen, and the normal person takes back IgM, IgE significantly increases.The Radix Astragali can promote organism metabolism, and slow down aging prolongs cell in the growth in vitro life-span, and antioxidation is arranged, and increases reticulocyte counts and bone marrow nucleated cell and counts effect.The Radix Astragali also has antitumaous effect, and the mice lung cancer sickness rate is reduced, and the melanoma of spontaneous generation reduces.
Radix Angelicae Sinensis is enriched blood and is invigorated blood circulation, and nourishes QI and blood, and the raise immunity effect is arranged, and leukocyte and reticulocyte are increased, and promotes spleen and thymus T, bone-marrow-derived lymphocyte propagation.Angelica lactone can strengthen the cytotoxic T cell function, increases killing activity.The external splenocyte propagation that promotes of Radix Angelicae Sinensis immunocompetence polysaccharide has immunoadjuvant function in the body.Antioxidation is arranged, eliminate free radical and delaying senility function and Antiradiation injury effect.And antitumor action is arranged, ascitic type tumor and ascitic type leukemia there are the effect of the time-to-live of prolongation, the antitumous effect of ability enhanced electronic phosphamide.
Radix Achyranthis Bidentatae, invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, it is descending to ignite, and the merit of subduing swelling and detoxicating is arranged.Radix Achyranthis Bidentatae has analgesia, antiinflammatory action, and reaction has extremely significantly inhibitory action to the mice acetic acid twisting.Analgesic activity is strong and lasting.Resist inflammation on repercussive function is arranged, the phagocytic activity of ability activating macrophage, human body immunity improving function.Microcirculation improvement promotes inflammatory lesion to absorb.Inokopolyose has obvious inhibitory action to tumor cell.Can strengthen the lethal effect of macrophage to sarcoma S180.The Radix Achyranthis Bidentatae total saponins is external to have stronger inhibitory action to ehrlich ascites cell, and can improve bone density, prevents osteoporosis.
Rhizoma Curcumae Longae, the removing blood stasis circulation of qi promoting, the eliminating evil evil of warding off is returned the spleen Liver Channel, and property is dry and warm, and cloudy middle-jiao yang, function of the spleen and stomach is also.Rhizoma Curcumae Longae has antiinflammatory, hepatoprotective effect, and anticoagulant and anticoagulant effect are arranged.Curcumin has obvious inhibitory action to the MC lung transfer of high-metastasis tendency, and multiple cancerous cell such as sarcoma S180 cell, human colon cancer cell, kidney cancer cell, HCC are all had apoptosis-induced effect.
Rhizoma Fagopyri Dibotryis, heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation has anticancer and the promotion immunity function.Rhizoma Fagopyri Dibotryis has remarkable inhibitory action to mice lewis pulmonary carcinoma and cervical cancer, and the curative effect of female mice is good than male mice.Rhizoma Fagopyri Dibotryis root element is the strongest to adenocarcinoma of lung, SCC, nasopharyngeal squamous cell carcinoma inhibitory rate of cell growth; Can make film RNA, the DNA metabolism karyokinesis damaged of cancerous cell; The adenocarcinoma of stomach cell also there is obvious inhibitory action, and can effectively suppresses MC spontaneous transfer in the mice body.Aspect immunologic function, Rhizoma Fagopyri Dibotryis can significantly improve the phagocytic index of normal mouse reticuloendothelial system, improves the phagocytic index of tumor-bearing mice reticuloendothelial system simultaneously, and the antipyretic and anti-inflammatory effect is arranged.
The method for preparing of above-mentioned inhibition tumor and enhancing immunity Chinese medicine preparation; May further comprise the steps: 1, earlier medical material is washed, with medical material natural drying or oven dry such as Radix Ginseng, Poria, the Radix Astragali, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Rhizoma Curcumae Longae, Rhizoma Fagopyri Dibotryiss, pulverizing is 60 ~ 80 order medicated powder; Mix homogeneously; Using concentration is 75% ethanol extraction 3 times, each 12 hours extraction times, filters, concentrates, dry activity extract; 2, residue is put into extractor, soak decoction, 2.5 ~ 3 hours for the first time, leach; Decocted 1.5 ~ 2 hours for the second time, leach.With twice filtrating merge activity extract; 3, the activity extract that " 1 ", " 2 " is obtained stirs, and is thick paste, dries, is ground into 100 ~ 200 order fine powders, gets powder, adds appropriate amount of auxiliary materials, processes capsule, tablet, granule or drop pill with common process.
Adjuvant is meant filler, lubricant.Filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose.Lubricant comprises one or more in micropowder silica gel, Pulvis Talci, the magnesium stearate.
The void of Chinese medicine preparation revisal gas of the present invention improves immunity, strengthening the body resistance, regulating qi-flowing for strengthening spleen, blood circulation promoting and dispersing pathogen accumulation, eliminating evil detoxifcation.The enhanced natural killer cell activity is directly killed or anticancer propagation cancerous cell, and it is obvious to suppress the malignant tumor effect; Through regulating the mass action of body, reach the purpose of strengthening the body resistance, treating both the principal and secondary aspects of a disease, treatment cycle is short, effect is obvious.After general patient took medicine two months, immunity obviously strengthened, and promoted the life-span to prolong.
Prove that through clinical practice and this Chinese medicine preparation function of enhancing immunity experimental data Chinese medicine preparation of the present invention not only is suitable for malignant tumor patient to be improved immunity, suppress malignant tumor; Also be suitable for body constitution void person and take raising immunity, health invigorating, prophylaxis of tumours.
Preparation pharmacodynamics of the present invention, toxicity study and clinical setting are following:
Get the prescription of embodiment 2: 45 parts of Radix Ginsengs, 30 parts in Poria, 30 parts of the Radixs Astragali, 45 parts of Radix Angelicae Sinensis, 30 parts of Radix Achyranthis Bidentataes, 60 parts in Rhizoma Curcumae Longae, Rhizoma Fagopyri Dibotryis is processed this Chinese medicine preparation by method for preparing for 60 parts and does pharmacodynamic experiment (table 1-table 7).
1.MTT it is active that method detects the anti-humanized's cancer cell multiplication of this Chinese medicine preparation.
Table 1: MTT assay of the Chinese medicine anti-proliferative activity in A549 cells results (
)
| Group | Dosage (
 |
OD(570 nm) | Suppression ratio ( %) |
| Solvent control | ? | 1.484±0.027 | ? |
| Chinese medicine preparation | 7.8 | 1.148±0.027 | 22.4 |
| ? | 15.6 | 1.128±0.024 | 24.0 |
| ? | 31.3 | 0.863±0.029 | 41.8 |
| ? | 62.5 | 0.716±0.010 | 51.7 |
| ? | 125 | 0.619±0.016 | 58 |
Annotate: A549 is a human lung carcinoma cell line.
Table 2: MTT assay of the Chinese medicine anti-proliferative activity of K562 cells results (
)
| Group | Dosage (
 |
OD(570 nm) | Suppression ratio ( %) |
| Solvent control | ? | 0.554±0.086 | ? |
| Chinese medicine preparation | 7.8 | 0.385±0.012 | 27.5 |
| ? | 15.6 | 0.404±0.051 | 30.5 |
| ? | 31.3 | 0.355±0.042 | 36.0 |
| ? | 62.5 | 0.315±0.026 | 43.2 |
| ? | 125 | 0.271±0.046 | 51.1 |
Annotate: k562 is human erythroleukemia cell's strain.
Table 3: MTT assay of the Chinese medicine anti-proliferative activity OVC2780 results (
)
| Group | Dosage (
 |
OD(570 nm) | Suppression ratio ( %) |
| Solvent control | ? | 1.495±0.032 | ? |
| Chinese medicine preparation | 7.8 | 1.023±0.034 | 34.7 |
| ? | 15.6 | 0.879±0.016 | 41.5 |
| ? | 31.3 | 0.790±0.012 | 47.2 |
| ? | 62.5 | 0.687±0.023 | 54.0 |
| ? | 125 | 0.456±0.015 | 69.4 |
Annotate: OVC2780 is the human oophoroma cell line.
Table 4: MTT assay SMMC7721 the Chinese medicine anti-proliferative activity results (
)
| Group | Dosage (
 |
OD(570 nm) | Suppression ratio ( %) |
| Solvent control | ? | 1.199±0.036 | ? |
| Chinese medicine preparation | 7.8 | 0.953±0.052 | 24.4 |
| ? | 15.6 | 0.863±0.031 | 30.2 |
| ? | 31.3 | 0.738±0.021 | 38.4 |
| ? | 62.5 | 0.540±0.019 | 55.0 |
| ? | 125 | 0.386±0.017 | 68.8 |
Annotate: SMMC7721 is a human hepatoma cell strain.
Can find out that from table 1, table 2, table 3, table 4 this Chinese medicine preparation all has obvious inhibitory action to human lung carcinoma cell line, human hepatoma cell strain, human erythroleukemia cell's strain and human oophoroma cell line, and with dosage dependence is arranged.
2. this Chinese medicine preparation function of enhancing immunity experiment
Mtt assay detects the influence that this Chinese medicine preparation transforms the inductive mouse spleen lymphocyte of ConA.
Get 40 of cleaning level healthy male mices, 10 every group, be divided into four groups immediately, i.e. matched group, large, medium and small dose groups.Behind the gastric infusion one month, the cervical vertebra dislocation method is put to death animal, grinds spleen, processes the individual cells suspension, filters through 200 orders, and centrifugal treating divides metering-orifice to add in the culture plate cell suspension, cultivates 72 hours.Every hole is inhaled and is removed the 0.7ml supernatant, adds the RPMI-1640 that does not contain calf serum, cultivates after 4 hours, adds 1ml acid isopropyl alcohol, and purple crystal is dissolved fully.Put into 96 well culture plates, under 570nm, measure OD value with enzyme inspection appearance.
Table 5: MTT assay of the traditional Chinese medicine preparation for ConA-induced lymphocyte transformation results (
)
| Group | Dosage (
 |
Number of animals | Add the ConA hole and do not add ConA hole absorbance difference |
| Blank | 0 | 10 | 0.013±0.023 |
| Small dose group | 0.22 | 10 | 0.015±0.015 |
| Middle dose groups | 0.44 | 10 | 0.018±0.001 |
| Heavy dose of group | 1.30 | 10 | 0.024±0.006* |
Annotate: compare * P < 0.05 with matched group
From table, can find out that the OD value of big or middle dose groups is apparently higher than the optical density difference of matched group.
This Chinese medicine preparation is engulfed the chicken red blood cell experiment to Turnover of Mouse Peritoneal Macrophages.
Get 40 of cleaning level healthy male mices, 10 every group, be divided into 4 groups at random, i.e. matched group, large, medium and small dose groups.Gastric infusion is 1 month continuously, the chicken erythrocyte suspension of preparation 20% (v/v), and every lumbar injection 1ml, mice is put to death in cervical vertebra dislocation in 30 minutes at interval; Cut off skin of abdomen, the abdominal cavity injects normal saline, peritoneal fluid is taken out drip on 2 microscope slides then, puts in the incubator 30 minutes; Take out, dry, fix, with 4% (v/v) Giemsa phosphate buffer dyeing 3 minutes with 1:1 acetone methanol solution with the normal saline rinsing; Dry mounting, om observation result.
Table 6: The Chinese medicine on mouse peritoneal macrophage phagocytosis and phagocytic index phagocytic rate effect (
)
| Group | Dosage (g/kg.bw) | Number of animals | Phagocytic percentage | Phagocytic index |
| Blank | 0 | 10 | 17.8+4.6 | 0.26±0.11 |
| Small dose group | 0.22 | 10 | 21.8±2.7 | 0.32±0.14 |
| Middle dose groups | 0.44 | 10 | 24.6±3.2 | 0.33±0.06 |
| Heavy dose of group | 1.30 | 10 | 25.3±4.1* | 0.36±0.10* |
Annotate: compare * P < 0.05 with matched group
Can find out that from table 6 each group of Chinese medicine has been compared notable difference with matched group.Heavy dose of group phagocytic rate and phagocytic index are apparently higher than matched group.
This Chinese medicine preparation is to the influence of humoral immune function
Get 40 of cleaning level healthy male mices, 10 every group, be divided into four groups at random.Be matched group, large, medium and small dose groups, successive administration 20 days, after the administration the 10th day, to each group ip in mice 0.5%, chicken RBC normal saline 0.2ml/ only exerted oneself epidemic disease and handles.After 10 days, the eye socket vein is got blood, by immunogenic hemolysin algoscopy, detects and respectively organizes mice hemolysin content.
Table 7. The traditional Chinese medicine preparation for hemolysin Content (
)
Annotate: with matched group relatively * P 0.05, * * P < 0.01
Can find out that from table each group of Chinese medicine is compared with matched group, hemolysin content is apparently higher than matched group.
The prescription dosage of embodiment 1 is big, gets its prescription: 30 parts of Radix Ginsengs, and 60 parts in Poria, 60 parts of the Radixs Astragali, 60 parts of Radix Angelicae Sinensis, 60 parts of Radix Achyranthis Bidentataes, 90 parts in Rhizoma Curcumae Longae, Rhizoma Fagopyri Dibotryis is processed this Chinese medicine preparation by method for preparing for 90 parts and does toxicity study experiment (table 8).
3. this Chinese medicine preparation (getting embodiment 1) acute toxicity testing result
Table 8: acute toxicity testing
Annotate: compare * P with matched group 0.05
This Chinese medicine preparation was given mouse stomach with maximum concentration, maximum volume in 4 hours in 1 day at interval, and the accumulative total dosage is 298.4g/kg, animal dead all do not occur, by the body weight conversion, was equivalent to be grown up 472 times of clinical consumption of 70kg, explained that this Chinese medicine preparation is safe.
The specific embodiment:
Embodiment 1:
Get 30 parts of Radix Ginsengs, 60 parts in Poria, 60 parts of the Radixs Astragali, 60 parts of Radix Angelicae Sinensis, 60 parts of Radix Achyranthis Bidentataes, 90 parts in Rhizoma Curcumae Longae, 90 parts of Rhizoma Fagopyri Dibotryiss.
Method for preparing: earlier medical material is washed, natural drying or oven dry, pulverizing are 60 ~ 80 order medicated powder, mix homogeneously, with ethanol extraction 3 times, filter, concentrate, dry must activity extract; Residue is put into extractor, soaks secondary and decoct, leach, with twice filtrating merge active extraction; The activity extract that secondary is obtained stirs, and is thick paste, dries, is ground into 100 ~ 200 order fine powders, gets powder, processes capsule with common process, and 500 milligrams every, usage: every day 3 times, each 4, plain boiled water is taken after mixing it with water.
Embodiment 2:
Get 45 parts of Radix Ginsengs, 30 parts in Poria, 30 parts of the Radixs Astragali, 45 parts of Radix Angelicae Sinensis, 30 parts of Radix Achyranthis Bidentataes, 60 parts in Rhizoma Curcumae Longae, 60 parts of Rhizoma Fagopyri Dibotryiss.Method for preparing is the same, processes capsule with common process, and 500 milligrams every, usage: every day 3 times, each 4, plain boiled water is taken after mixing it with water.
Embodiment 3:
Get 20 parts of Radix Ginsengs, 30 parts in Poria, 30 parts of the Radixs Astragali, 30 parts of Radix Angelicae Sinensis, 20 parts of Radix Achyranthis Bidentataes, 30 parts in Rhizoma Curcumae Longae, 45 parts of Rhizoma Fagopyri Dibotryiss.
Method for preparing is the same, processes capsule with common process, and 500 milligrams every, usage: every day 3 times, each 4, plain boiled water is taken after mixing it with water.
Clinical trial:
1. patient, the man, 48 years old, through CT examination, find that inferior lobe of right lung has the irregular solid tumor mass of 1.2cm * 1.9cm during health check-up, internal density is inhomogeneous, the enlargement of right lung door knot, local pleural thickening, vertical phrenic lymph nodes increases, and cough, symptom such as uncomfortable in chest are arranged at ordinary times.Through getting biopsy diagnosis is to break up adenocarcinoma in the inferior lobe of right lung.After the operation,, take medicine (embodiment 1 side) two months without chemotherapy, patient's cough, recovery from illness uncomfortable in chest, through CT examination, the lump complete obiteration.After taking medicine three months, inspection tumor markers each item index is normal again, and cancer antigens c A-125 is 6.94 μ/ml, and cancer antigens c A-153 is 3.45k μ/l, all in normal value.
2. patient, the woman, 44 years old, vagina was surplus the irregular March of bleeding, and has stomachache.Through examination in hospital, cervical hypertrophy, visible irregular matter echo in the uterine cavity.Cervix uteri and uterine cavity scrape thing and are broken endometrioid adenocarcinoma tissue, big or small 3.0cm * 2.0cm * 1.0cm.After the operation, lump disappears, and without chemotherapy, checks after three months that through take medicine (embodiment 3 sides) each item index is normal, follows up a case by regular visits to 1 year, and imaging examination is normal.
3. patient, the man, 62 years old, to suffer from abdominal pain nearly 2 years, in May, 2008 is through CT examination, the density that notes abnormalities shadow.It is intestinal cancer that biopsy diagnosis is got in enteroscopy, and size is 1.2cm * 0.8cm * 0.8cm.Underwent operative, chemotherapy are not checked after four months through take medicine (embodiment 2 sides), and lump disappears, and immunity obviously improves, and imaging examination is normal.
Claims (4)
1. Chinese medicine preparation that suppresses tumor and enhancing immunity, it is characterized in that: its crude drug and weight proportion are following: 25～70 parts of Radix Ginsengs, 50～100 parts in Poria; 50～100 parts of the Radixs Astragali, 60～110 parts of Rhizoma Fagopyri Dibotryiss, 50～100 parts of Radix Angelicae Sinensis; 40～80 parts of Radix Achyranthis Bidentataes, 60～110 parts in Rhizoma Curcumae Longae.
2. the Chinese medicine preparation of inhibition tumor according to claim 1 and enhancing immunity is characterized in that: its crude drug and weight proportion are following: 30 parts of Radix Ginsengs, 60 parts in Poria, 60 parts of the Radixs Astragali, 60 parts of Radix Angelicae Sinensis, 60 parts of Radix Achyranthis Bidentataes, 90 parts in Rhizoma Curcumae Longae, 90 parts of Rhizoma Fagopyri Dibotryiss.
3. the Chinese medicine preparation of inhibition tumor according to claim 1 and enhancing immunity is characterized in that: it is capsule, tablet or granule.
4. the method for preparing of the Chinese medicine preparation of inhibition tumor as claimed in claim 3 and enhancing immunity; It is characterized in that: may further comprise the steps: (1), elder generation wash medical material, and with Radix Ginseng, Poria, the Radix Astragali, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Rhizoma Curcumae Longae, Rhizoma Fagopyri Dibotryis medical material natural drying or oven dry, pulverizing is 60～80 order medicated powder; Mix homogeneously; Using concentration is 75% ethanol extraction 3 times, each 12 hours extraction times, filters, concentrates, dry activity extract; (2), residue is put into extractor, soak decoction, 2.5～3 hours for the first time, leach; Decocted 1.5～2 hours for the second time, leach; With twice filtrating merge activity extract; (3), activity extract that step (1), (2) are obtained stirs, and is thick paste, dries, is ground into 100～200 order fine powders, powder, add appropriate amount of auxiliary materials, process capsule, tablet, granule with common process.
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| CN104799171A (en) * | 2015-05-07 | 2015-07-29 | 王小华 | Medicinal food for gastric carcinoma patient to administrate and preparation method of medicinal food |
| CN107772479A (en) * | 2017-11-28 | 2018-03-09 | 吉安市御美丽健康产业股份有限公司 | A kind of black-bone chicken peptide health-care food for improving immunity and preparation method thereof |
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