CN101530580B

CN101530580B - Drug for curing ulcerative colitis

Info

Publication number: CN101530580B
Application number: CN2009100741667A
Authority: CN
Inventors: 路正平
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-04-14
Filing date: 2009-04-14
Publication date: 2011-09-07
Anticipated expiration: 2029-04-14
Also published as: CN101530580A

Abstract

A drug for curing ulcerative colitis is prepared by the following steps: mixing concocted plantain seed, rhizoma corydalis, radix astragali with rhizoma atractylodis macrocephalae, yam, poria, evodia rutaecarpa, malaytea scurfpea fruit, semen nelumbinis, gordon euryale seed, halloysit, hawthorn coke, fried malt, fried Chen Qu and the like, decocting the ingredients in water for 3 times, combining decoction, filtering and concentrating the decoction into clear paste, drying and grinding the clear paste, encapsulating the clear paste and then sterilizing the clear paste to prepare the capsule product. The invention has the effects of invigorating the spleen and drying damp, relieving diarrhea with astringents, activating blood and dissolving stasis, removing necrosis and promoting granulation, regulating vital energy and relieving stagnation, addresses both the symptoms and root causes of ulcerative colitis and has confirmed curative effect and no toxic side effects. The clinical observation shows the total effective rate can attain 95.0%.

Description

A kind of medicine for the treatment of ulcerative colitis

Technical field

The present invention relates to a kind of medicine for the treatment of ulcerative colitis, particularly relating to a kind of is the Chinese medicine medicine of the treatment ulcerative colitis of feedstock production with Chinese medicine.

Background technology

Ulcerative colitis claims chronic non-specific ulcerative colitis again, and the pathological changes multidigit also can spread to descending colon in rectum and sigmoid colon, even whole colon.Clinical cardinal symptom is diarrhoea, bloody purulent stool, stomachache and tenesmus.Modern medicine thinks that this disease is that self cellular immunization is unusual, cause mucosa destroyed, or because Nervous and Mental Factors causes the cerebral cortex moving obstacle, autonomic nervous dysfunction and to produce intestinal movement hyperfunction, intestinal vascular smooth muscle spasm is shunk, tissue ischemia, capillary permeability increases, thereby forms inflammation, erosion and the ulcer of intestinal mucosa.

At present, the western medical treatment ulcerative colitis mainly contains a few class medicines such as sulfonamides, antibiotics, hormones, immunosuppressant, said medicine all proves to have reliable therapeutic effect by the long-term test of pesticide effectiveness and clinical trial, but toxicity is big mostly, side effect is many, symptoms such as nausea and vomiting, headache, general malaise are often arranged as oral sulfa drugs, or cause leukopenia, arthralgia, erythra, albuminuria etc.; The oral gastrointestinal irritation that easily causes of antibiotic medicine, the intravenous administration toxic and side effects is big; Immunosuppressant is bigger to the influence of hemopoietic function of bone marrow, answers the periodic review bone marrow smear in the medication process.

Therefore, it is good to seek to have therapeutical effect, the Chinese medicine preparation that side reaction is few just seem very urgent and needs, actively develop this side and research have important use and be worth and clinical finger meaning.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of ulcerative colitis, this medicine the spleen strengthening and damp drying, relieving diarrhea with astringents, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, regulating qi-flowing for activating stagnancy are used for the treatment of the ulcerative colitis treating both the principal and secondary aspects of a disease, drug effect is rapid, therapeutic effect is good.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Rhizoma Atractylodis Macrocephalae (parched) 8～15 Rhizoma Dioscoreaes 10～25 Poria 10～20

Fructus Evodiae 8～15 Fructus Psoraleaes 8～15 Semen Nelumbinis 8～15

Semen Euryales 8～15 Fructus Schisandrae Chinensis 8～15 Halloysitum Rubrums 10～30

Semen Plantaginis 10～30 Rhizoma Corydalis 8～15 Radixs Astragali 10～20

Fructus Crataegi (parched to brown) 8～15 Fructus Hordei Germinatus (parched)s 8～15 Massa Medicata Fermentata (parched) 8～15

Radix Glycyrrhizae 2～5.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of medicine of the present invention being made capsule is:

Rhizoma Corydalis is fried to buff, and spray vinegar is fried and is done; The Radix Astragali is fried to buff, moistening with Mel, fry again and do; Semen Plantaginis is fried to explosion.

With the Rhizoma Corydalis, the Radix Astragali and the other drug that cook by above-mentioned parts by weight mix homogeneously, decoct with water 2～4 times, each 0.5～1 hour, collecting decoction filters, and being condensed into relative density is the clear paste of 1.0～1.2 (50 ℃), after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.

Ulcerative colitis is the modern medicine name of disease, though motherland's medical science does not have and its reciprocity fully name of disease, but according to the cause of disease, pathogenesis and clinical manifestation, often with its ownership " intestinal is out-of-the-way ", " have loose bowels ", " chronic dysentery ", " chronic dysentery with frequent relapse ", categories such as " hemorrhoidal hamorrhage ", at all times document think more because of natural endowment unusual, being invaded by exogenous pathogen, eating and drinking without temperance, disorder of emotion, due to the overstrain internal injury, its pathogeny is that turbid pathogen is jammed in the intestinal, conduction mistake department, and mechanism of qi is obstructed, stagnation of QI-blood, the intestinal network is impaired, and dysentery is red white, and treatment should be with heat-clearing and toxic substances removing, relieving diarrhea with astringents, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, regulating qi-flowing for activating stagnancy is main.In the prescription of the present invention, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae replenishing QI to invigorate the spleen, yin nourishing dampness; Poria diuretic, eliminating dampness by diuresis, spleen invigorating; Fructus Evodiae dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal; Fructus Psoraleae, Semen Nelumbinis, Semen Euryales, Fructus Schisandrae Chinensis is warming spleen and stopping diarrha, convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid; Halloysitum Rubrum, Semen Plantaginis astringing intestine to stop diarrhea eliminating dampness by diuresis antidiarrheal; The pain relieving of Rhizoma Corydalis blood-activating and qi-promoting; Radix Astragali air making-up and spleen enlivening, ascending up spleen-Qi and Yang; Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata (parched) invigorating the stomach and promoting digestion eliminate indigestion, the circulation of qi promoting dissipating blood stasis; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.All medicines share, and play the merit of the spleen strengthening and damp drying, relieving diarrhea with astringents, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, regulating qi-flowing for activating stagnancy altogether, are used for the treatment of the ulcerative colitis treating both the principal and secondary aspects of a disease, and curative effect really, rapidly, conveniently, and is without any side effects.

For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 200 routine patients of ulcerative colitis that the curative effect of Drug therapy ulcerative colitis of the present invention has been carried out clinical observation.

200 routine cases are divided into two groups at random, every group 100 example.Matched group man 54 examples, women 56 examples; Minimum 20 years old of age, maximum 59 years old, average 37.8 years old; The course of disease is the shortest 2 months, and is the longest 28 years; 52 examples that the state of an illness is slight, moderate 32 examples, severe 16 examples.Male 51 examples are organized in treatment, women 59 examples; Minimum 18 years old of age, maximum 62 years old, average 38.8 years old; The course of disease is the shortest 3 months, and is the longest 30 years; 54 examples that the state of an illness is slight, moderate 34 examples, severe 12 examples.All cases are all diagnosed with reference to the ulcerative colitis diagnostic criteria that the chronic non-infection intestinal tract disease scientific seminar that held in Taiyuan in 1993 formulates.

Matched group adopts FUPAISUAN JIAONANG 0.2g, gentamicin injection liquid 80,000 U, VITAMIN C TABLET 0.1g, vitamin B1 sheet 10mg, vitamin B6 sheet 10mg, prednisone acetate tablets 5mg, berberine hydrochloride tablet 0.4g, equal 3 times/d treatment.The treatment group adopts medicine of the present invention to treat, and 6 weeks were 1 course of treatment, took 2 courses of treatment altogether.

Criterion of therapeutical effect: cure: clinical symptom disappearance, intestinal mucosa recovers normal or leaves over cicatrix under the intestinal mirror, drug withdrawal or keep medicine and do not have recurrence in 6 months.Produce effects: clinical symptoms disappears substantially, and intestinal mucosa hyperemia under the intestinal mirror, edema petechia disappear substantially, and blood vessel increases roughcast to be stuck with paste, and ulcer is most of to disappear.Effectively: clinical symptom relief, mild inflammation reaction of intestinal mirror check mucosa and part pseudopolyp form.Invalid: clinical symptoms does not have change after treating, and intestinal mirror or barium coloclysis pathological changes do not have change.The results are shown in Table 1 after two groups of case treatments.

Table 1 liang group case treatment back curative effect relatively

The specific embodiment

Embodiment 1

Rhizoma Corydalis 150g is fried to buff, and spray vinegar is fried and is done; Radix Astragali 200g is fried to buff, add Mel to Radix Astragali surface wettability, fry again and do; It is to spend that Semen Plantaginis 300g fries to explosion.

The above-mentioned Chinese medicine that cooks and Rhizoma Atractylodis Macrocephalae (parched) 150g, Rhizoma Dioscoreae 250g, Poria 200g, Fructus Evodiae 150g, Fructus Psoraleae 150g, Semen Nelumbinis 150g, Semen Euryales 150g, Halloysitum Rubrum 300g, Fructus Schisandrae Chinensis 150g, Fructus Crataegi (parched to brown) 150g, Fructus Hordei Germinatus (parched) 150g, Massa Medicata Fermentata (parched) 150g, Radix Glycyrrhizae 50g are put into the electronics decocting medicine pot, add water 20L, be heated to boil after, with slow fire boiling 30min, pour out medicinal liquid, decoct with water again.Decoct three times continuously, mixed three medicinal liquids filter, and are condensed into the clear paste of 50 ℃ of relative densities 1.15, after 50 ℃ of dryings, are ground into 120 purpose medicated powder, and capsule is made in sterilization.

Embodiment 2

Rhizoma Corydalis 130g is fried to buff, and spray vinegar is fried and is done; Radix Astragali 180g is fried to buff, add Mel to Radix Astragali surface wettability, fry again and do; It is to spend that Semen Plantaginis 250g fries to explosion.

The above-mentioned Chinese medicine that cooks and Rhizoma Atractylodis Macrocephalae (parched) 130g, Rhizoma Dioscoreae 250g, Poria 180g, Fructus Evodiae 130g, Fructus Psoraleae 130g, Semen Nelumbinis 130g, Semen Euryales 130g, Halloysitum Rubrum 250g, Fructus Schisandrae Chinensis 130g, Fructus Crataegi (parched to brown) 130g, Fructus Hordei Germinatus (parched) 130g, Massa Medicata Fermentata (parched) 130g, Radix Glycyrrhizae 40g are put into the electronics decocting medicine pot, add water 20L, be heated to boil after, with slow fire boiling 30min, pour out medicinal liquid, decoct with water again.Decoct three times continuously, mixed three medicinal liquids filter, and are condensed into the clear paste of 60 ℃ of relative densities 1.1, after 50 ℃ of dryings, are ground into 100 purpose medicated powder, and capsule is made in sterilization.

Claims

1. medicine for the treatment of ulcerative colitis is that crude drug prepares by the Chinese medicine of following portions by weight:

Fructus Evodiae 8～15 Fructus Psoraleaes 8～15 Semen Nelumbinis 8～15

Semen Plantaginis 10～30 Rhizoma Corydalis 8～15 Radixs Astragali 10～20

Radix Glycyrrhizae 2～5.

2. the medicine of treatment ulcerative colitis according to claim 1 is characterized in that described medicine is made capsule.

3. the preparation method of the medicine of the described treatment ulcerative colitis of claim 2 comprises:

Rhizoma Corydalis is fried to buff, and spray vinegar is fried and is done; The Radix Astragali is fried to buff, moistening with Mel, fry again and do; Semen Plantaginis is fried to explosion;

With the Rhizoma Corydalis, the Radix Astragali and the other drug that cook by above-mentioned parts by weight mix homogeneously, decoct with water 2～4 times, each 0.5～1 hour, collecting decoction filters, and is condensed into 50 ℃ of relative densities and is 1.0～1.2 clear paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.