CN104013756A - Traditional Chinese medicine composition for preventing and treating diarrhea and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for preventing and treating diarrhea and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating diarrhea. The traditional Chinese medicine composition consists of the following material medicines in parts by weight: 3-9 parts of wrinkled giant hyssop, 3-9 parts of processed rhizoma pinelliae, 2-6 parts of elecampane, 3-9 parts of dried tangerine or orange peel, 1-3 parts of clove, 1-3 parts of cinnamon, 5-15 parts of rhizoma atractylodis, 4-12 parts of white atractylodes rhizome, 5-15 parts of poria cocos and 5-15 parts of coke hawthorn. The invention further discloses application of the traditional Chinese medicine composition in preparation of a drug for preventing and treating cold-damp type diarrhea according to the theory of traditional Chinese medicine. According to experimental animals and a clinical test, the traditional Chinese medicine composition disclosed by the invention is indicated to be good in safety and curative effect, so that the cold-damp type diarrhea according to the theory of traditional Chinese medicine can be effectively treated. The composition is a compound traditional Chinese medicine which is good in effect of improving clinical symptoms, small in toxic and side effect, and good in clinical application prospect.
Description
Technical field
The invention belongs to Chinese medicine technical field, relate to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of preventing and treating diarrhoea.
Background technology
Diarrhoea, as common clinical, is a kind of independently disease, is again a kind of symptom in various diseases pathology process.Statistics shows, China has 8.36 hundred million person-times to suffer from diarrhoea every year.Therefore, Ministry of Public Health is classified diarrhoea as one of disease of China's keypoint control.Diarrhoea can be divided into infectious and non-infectious two kinds according to the cause of disease.Wherein infectious diarrhea disease is that the diarrhoea of take being caused by pathogenic microorganism and product thereof or parasite is one group of infectious intestinal disease of main clinical manifestation, is one of important public health problem in the current whole world.The diarrhoea that China's law on the prevention and control of infectious diseases in 1989 causes the microorganism except cholera (category A infectious disease), dysentery, Typhoid and paratyphoid (Category B notifiable disease), is called " other infectious diarrheas are sick ", is listed as Class C infectious disease.At the sickness rate of China, occupy the prostatitis of Class C infectious disease, according to People's Republic of China's national health and Family Planning Committee statistics in 2012, show: in the Class C infectious disease of national statutory report, other venereal infection sickness rate occupy second, report that other infectious diarrhea cases amount to 885678 examples, wherein dead 17 examples.In the Class C infectious disease incidence number of in January, 2014 whole nation report, other infectious diarrhea diseases hold pride of place.
Although the treatment of various infectious diarrheas, along with the popularization of fluid replacement therapy and the raising of whole medical level have had very much progress, along with antibiotic abuse clinically, has been accelerated to the generation of enteric pathogenic bacteria drug resistance, has brought difficulty to clinical treatment.Because the control of the infectious diarrhea of new burst is still arduous, and the traditional Chinese medical science is paid attention to people's integral body, is particular about dialectically, emphasizes that resistance against diseases and the evil positive both sides growth and decline in vivo of adjusting body inherence change.Therefore for some new agnogenic infectious diarrhea, the traditional Chinese medical science can be on dialectical basis symptomatic treatment, the coupling of many methods, comprehensive collaborative, disease is realized to early intervention, alleviate patient's symptom, weaken the infringement of pathogen toxin to viscera organ, there is significant curative effect.
Open source literature report < < adds taste GEGEN QINLIAN TANG treatment damp-heat acute diarrhoea observation of curative effect > > (Heilungkiang Chinese medicine now, the 2nd phase 14-15 page in 2009) utilization adds utilization in taste GEGEN QINLIAN TANG side Herba Pogostemonis and Poria, be mainly used in treating damp-heat acute diarrhoea, with our indication difference to some extent.Open source literature is reported the clinical research > > (Shandong Traditional Chinese Medicine University of < < temperature intestinal ZHIXIE SAN navel-applying therapeutic infantile rotavirus enteritis (cold-dampness type) now, 2012 Master's thesis) use warm intestinal ZHIXIE SAN (Rhizoma Atractylodis, Rhizoma Et Radix Notopterygii, Cortex Cinnamomi, according to the ratio of 3:2:1, grind to the powder to sieve and mix, with Rhizoma Zingiberis Recens juice and water dilution furnishing thick paste, then spread on SHENQUE acupoint, every day, 7AM to 3PM continues to apply ointment or plaster 8 hours, change dressings once every day) navel-applying therapeutic cold-dampness type infantile rotavirus enteritis, although Rhizoma Atractylodis and the Cortex Cinnamomi of in side, having used Chinese medicine composition of the present invention to mention, but very large with Chinese medicine composition difference of the present invention, its prescription mechanism is also different.The < < of open source literature report adds taste Radix Pulsatillae Decoction treatment children's bacillary dysentery 180 routine > > (Jiangsu Chinese medicine magazines now, in the 1st phase of calendar year 2001 45 pages of sides, also use and have the Radix Aucklandiae, but other medication and Chinese medicine composition difference of the present invention are very large, and comparability is not strong.In document, report the Chinese medicine of the compound recipe combination in we, all combine with other medicine and use just performance to have certain effect of controlling diarrhoea, but all inconsistent with the described Chinese medicine of Chinese medicine composition of the present invention, this combination is that after the combination of screening kinds of traditional Chinese medicines, this compositions of discovery is organically being combined according to a certain percentage, it is better that it prevents and treats the effect of cold-damp diarrhoea, it is to do the as a whole effect of playing synergy, has brought into play the curative effect that each single medicinal material can not embody.Existing document and publication are there are no the effect of the cold-damp diarrhoea about said composition, creative.
Summary of the invention
One of the technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition of preventing and treating diarrhoea.
Two of the technical problem to be solved in the present invention is to provide a kind of purposes of this Chinese medicine composition.
In one aspect of the invention, a kind of Chinese medicine composition of preventing and treating diarrhoea is provided, by the crude drug of following weight portion, is formed: 5～15 parts of 3～9 parts of Herba Pogostemoniss, 3～9 parts of Rhizoma Pinelliae Preparata, 2～6 parts of the Radix Aucklandiae, 3～9 parts of Pericarpium Citri Reticulataes, 1～3 part of Flos Caryophylli, 1～3 part of Cortex Cinnamomi, 5～15 parts of Rhizoma Atractylodis, 4～12 parts of the Rhizoma Atractylodis Macrocephalaes, 5～15 parts, Poria and Fructus Crataegi (parched to brown)s.Wherein, preferred weight portion proportioning is: 3 parts of Herba Pogostemoniss, 3 parts of Rhizoma Pinelliae Preparata, 2 parts of the Radix Aucklandiae, 3 parts of Pericarpium Citri Reticulataes, 1 part of Flos Caryophylli, 1 part of Cortex Cinnamomi, 5 parts of Rhizoma Atractylodis, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Poria, 5 parts of Fructus Crataegi (parched to brown)s.
Chinese medicine composition of the present invention is according to theory of Chinese medical science reasonable formula, the effective Chinese medicine compound of clinical application, Herba Pogostemonis gas soon in side, and in, ward off dirty, eliminating dampness to stop diarrhea; Cortex Cinnamomi and Flos Caryophylli are share energy complement sun, warming middle-JIAO is cold with the abdominal part that falls apart; Rhizoma Atractylodis and Rhizoma Atractylodis Macrocephalae energy strengthening the spleen and stomach dampness, then in conjunction with Poria with invigorating middle warmer spleen invigorating, control having loose bowels of insufficiency of the spleen leading to overabundance of dampness; And the gas of Radix Aucklandiae benefaction gastrointestinal and pain relieving is equipped with Rhizoma Pinelliae Preparata dampness preventing or arresting vomiting is alleviated because of stomachache and the vomiting of damp due to having loose bowels; Give again focus hawthorn digesting with antidiarrheal.Perfect square coupling energy dispelling cold and dehumidification, warming spleen and stopping diarrha, for cold-damp, have loose bowels, rare clearly for having loose bowels to clinical manifestation, as water sample, stomachache borborygmus, the vexed lack of appetite of gastral cavity, can have good efficacy with poisoning symptoms such as heating, nausea and vomiting, borborygmus stomachache.We are the compound recipes based on instruction of Chinese Medicine theory, it is an organic whole, the performance of its curative effect neither a composition or certain a herb can substitute completely, and experimentation shows, it is best that we make when as a whole its curative effect, than single medicinal material result of use, has significant synergy effect.
Chinese medicine composition of the present invention can directly or after extracting processing be made various oral medicinal herb conventional dose for prevention and treatment diarrhoea with pharmaceutically acceptable pharmaceutical carrier by the conventional method of this area.Described extraction processing technique, can be used the known Traditional Chinese medicine extraction method of prior art, such as but not limited to solvent extraction method, steam distillation, sublimed method, supercritical extraction etc.
Described pharmaceutical dosage forms can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch; Preferred oral dosage form, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.Described peroral dosage form can contain conventional excipient, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet if desired.Suitable filler comprises cellulose, mannitol, lactose and other similar filler; Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate; Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of suitable medicine comprises sodium lauryl sulphate etc.
A second aspect of the present invention has been to provide the application of described Chinese medicine composition in the medicine of preparation control diarrhoea, particularly in preparation, prevents and treats the application in the medicine of cold-damp diarrhoea.Traditional Chinese medical science cold-damp diarrhoea, clinical manifestation is rare clearly for having loose bowels, very as water sample, stomachache borborygmus, the vexed lack of appetite of gastral cavity, can be with poisoning symptoms such as heating, nausea and vomiting, borborygmus stomachache.
Results of animal proves, Chinese medicine composition of the present invention has the effect of obvious treatment diarrhoea, and independently the effect of certain Herba indigoferae Pseudotinctoriae does not all reach the common effect of using of this Chinese medicine composition, embodied the synergistic function of each combination of components.Clinical experiment result shows, Chinese medicine composition of the present invention has significance curative effect to cold-damp diarrhoea, and its effect is thought close better efficacy than contrast Western medicine.The present invention shows through laboratory animal and clinical trial card, and safety is good, and curative effect is good, can effectively treat traditional Chinese medical science cold-damp diarrhoea, and said composition is that a kind of to improve clinical symptoms effective, and toxic and side effects is little, has the herbal mixture of good potential applicability in clinical practice.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.The experimental technique of unreceipted actual conditions in the following example, conventionally according to normal condition or the condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percent, ratio, ratio or umber by weight.
Embodiment 1: oral liquid
By following weight proportion, get raw material: 300 grams of Herba Pogostemoniss, 300 grams of Rhizoma Pinelliae Preparata, 200 grams of the Radix Aucklandiae, 300 grams of Pericarpium Citri Reticulataes, 100 grams of Flos Caryophyllis, 100 grams of Cortex Cinnamomis, 500 grams of Rhizoma Atractylodis, 400 grams of the Rhizoma Atractylodis Macrocephalaes, 500 grams, Poria, 500 grams of Fructus Crataegi (parched to brown)s.Above ten tastes decocted with water 2 times, from boiling timing, each 1 hour, 10 times of water gagings, add 8 times of water gagings, after decoction for the second time for the first time, merge decoction liquor twice, let cool 3000rpm centrifugal 10 minutes, remove supernatant, concentrated, then add proper auxiliary materials, according to existing known holding up, make oral liquid 1L, by every bottle of 10ml subpackage, obtain oral 3 times of every day, each 1 bottle.
Embodiment 2: granule
By following weight proportion, get raw material: 3000 grams of Herba Pogostemoniss, 3000 grams of Rhizoma Pinelliae Preparata, 2000 grams of the Radix Aucklandiae, 3000 grams of Pericarpium Citri Reticulataes, 1000 grams of Flos Caryophyllis, 1000 grams of Cortex Cinnamomis, 5000 grams of Rhizoma Atractylodis, 4000 grams of the Rhizoma Atractylodis Macrocephalaes, 5000 grams, Poria, 5000 grams of Fructus Crataegi (parched to brown)s.Above ten decocted with water 2 times simply, from boiling timing, each 1 hour, 10 times of water gagings, add 8 times of water gagings, after decoction for the second time for the first time, merge decoction liquor twice, let cool 3000rpm centrifugal 10 minutes, remove supernatant, be concentrated into proportion and be 1.35 extractum, add appropriate dextrin and Icing Sugar, in 70 ℃ dry after, granulation 5000g granulates, and by every bag of 5g subpackage, obtains, oral 3 times of every day, each 1 bag.
Embodiment 3: tablet
By following weight proportion, get raw material: 3000 grams of Herba Pogostemoniss, 3000 grams of Rhizoma Pinelliae Preparata, 2000 grams of the Radix Aucklandiae, 3000 grams of Pericarpium Citri Reticulataes, 1000 grams of Flos Caryophyllis, 1000 grams of Cortex Cinnamomis, 5000 grams of Rhizoma Atractylodis, 4000 grams of the Rhizoma Atractylodis Macrocephalaes, 5000 grams, Poria, 5000 grams of Fructus Crataegi (parched to brown)s.Above ten decocted with water 2 times simply, from boiling timing, each 1 hour, 10 times of water gagings, add 8 times of water gagings, after decoction for the second time for the first time, merge decoction liquor twice, let cool 3000rpm centrifugal 10 minutes, get supernatant, subtract and be concentrated into into dry cream, by the known method of prior art, make tablet again, every 0.3 gram, oral 3 times of every day, each 3.
Embodiment 4: capsule
Five kinds of Traditional Chinese medicine compound composition weight proportions for the treatment of diarrhoea that provide by table 1 take raw material, form respectively compound recipe A, Compound B, compound recipe C, compound recipe D, five kinds of Traditional Chinese medicine compound compositions of compound recipe E, and its formula table is in Table 1, in table 1, and 100 grams every part of consumptions.Add respectively suitable quantity of water and decoct 2 times, from boiling timing, each 1 hour, after decoction, merge twice decoction liquor, concentrating under reduced pressure, then lyophilization is to lyophilized powder, standby as composition freeze-dried powder.By the known method of prior art, make capsule again, 0.3 gram every, oral 3 times of every day, each 3.
The Traditional Chinese medicine compound composition table of five kinds of anti-hepatitis C of table 1.
Embodiment 5: decoction liquor
By following weight proportion, get raw material: 15 grams of 9 grams of Herba Pogostemoniss, 9 grams of Rhizoma Pinelliae Preparata, 6 grams of the Radix Aucklandiae, 9 grams of Pericarpium Citri Reticulataes, 3 grams of Flos Caryophyllis, 3 grams of Cortex Cinnamomis, 15 grams of Rhizoma Atractylodis, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 15 grams, Poria and Fructus Crataegi (parched to brown)s.Add suitable quantity of water and decoct 2 times, from boiling timing, each 1 hour, after decoction, merge twice decoction liquor, instructions of taking is: in one day, a minute secondary is taken.
Embodiment 6: Chinese medicine composition of the present invention and each comparative study of single medicinal material body to diarrhea mice curative effect
By following weight proportion, get raw material: 150 grams of 90 grams of Herba Pogostemoniss, 90 grams of Rhizoma Pinelliae Preparata, 60 grams of the Radix Aucklandiae, 90 grams of Pericarpium Citri Reticulataes, 30 grams of Flos Caryophyllis, 30 grams of Cortex Cinnamomis, 150 grams of Rhizoma Atractylodis, 120 grams of the Rhizoma Atractylodis Macrocephalaes, 150 grams, Poria and Fructus Crataegi (parched to brown)s.Adding suitable quantity of water decocts 2 times, from boiling timing, each 1 hour, after decoction, merge decoction liquor twice, concentrating under reduced pressure, lyophilization is to lyophilized powder again, standby as composition freeze-dried powder (ZHW), other each single medicinal material is got in compositions and is measured accordingly, press preparation method of composition, after decocting and concentrating, make lyophilized powder, make respectively Herba Pogostemonis lyophilized powder (HX), Rhizoma Pinelliae Preparata lyophilized powder (ZBX), Radix Aucklandiae lyophilized powder (MX), Pericarpium Citri Reticulatae lyophilized powder (CP), Flos Caryophylli lyophilized powder (DX), Cortex Cinnamomi lyophilized powder (RG), Rhizoma Atractylodis lyophilized powder (CZ), Rhizoma Atractylodis Macrocephalae lyophilized powder (BZ), Poria lyophilized powder (FL), Fructus Crataegi (parched to brown) lyophilized powder (JSZ), standby.
Select 60 of Kunming mouses, be divided at random 13 groups, 10 every group; If blank group, model group, positive drug group (dioctahedral smectite), each medicine group (ZHW group, HX group, ZBX group, MX group, CP group, DX group, RG group, CZ group, BZ group, FL group and JSZ group).Except blank group, the equal lumbar injection Escherichia coli bacteria liquids of all the other treated animals (0.3ml/10g) cause severe diarrhea model, blank group lumbar injection equivalent normal saline.After 3 hours, blank group and model group mouse stomach normal saline; Treatment group mice is respectively organized dosage for being respectively 50mg/kg; Positive controls dioctahedral smectite dosage is 20mg/kg.After experiment starts, observe in lumbar injection escherichia coli injection 3h 3h inner model group and each treatment group after diarrhea of mouse situation and administration, positive controls diarrhea of mouse situation (comprise loose stool number of times, always just number of times, loose stool level), and calculate Scours index.Observed content: the general state of (1) mice and behavioristics change: the variation of the mental status, figure's fur, diet situation, stool.(2) mensuration of Scours index: statistics loose stool number of times, always just number of times, loose stool level, calculate Scours index.
Experimental result shows, diarrhoea in various degree appears in lumbar injection Escherichia coli bacteria liquid after 1 hour, show as just time increase, just matter rare soft, to 3rd hour diarrhoea situation, obviously aggravate, some mice is obvious fatigue and weakness, lethargy, rare watery stool.After Drug therapy, the diarrhea of mouse symptom of positive drug group and the administration of ZHW group is obviously improved, and shows as stool number and reduces, and just matter is become a cadre by rare, and the mental status is gradually good, and diet recovers, and emotion is slightly shown in excitement.The symptom that other administration group has has comparatively obviously to be improved, and some symptoms are improved not obvious, and all there were significant differences (P<0.01) with ZHW group for its therapeutic effect, do not reach the therapeutic effect of compositions, and main result is in Table 2.Experimental result shows, Chinese medicine composition of the present invention has the effect of obvious treatment diarrhoea, and independently the effect of certain Herba indigoferae Pseudotinctoriae does not all reach the common effect of using of compositions.
The different compound extract lyophilized powders of table 2. cause the impact of the curative effect of diarrhea mice on escherichia coli
Note:
*there are significant differences, P<0.01 with model group;
##relatively there are significant differences, P<0.01 with ZHW group.
Embodiment 7: the comparative study of the different proportioning Chinese medicine compositions of the present invention to diarrhea mice curative effect
Get five kinds of prepared compound recipe A of " embodiment 4 ", Compound B, compound recipe C, compound recipe D, compound recipe E lyophilized powder as experimental subject, according to " embodiment 6 ", adopt the mice of lumbar injection Escherichia coli bacteria liquid modeling to investigate the effect for the treatment of infectious diarrhea of the compositions of different proportionings.With model group comparison, different proportioning compositions groups are significantly lower than model group P<0.01, and there was no significant difference between each proportioning group.The results are shown in Table 3.Experimental result shows, according to the different proportionings of the present composition, treatment diarrhoea is all had to significant curative effect, and namely the proportioning in the scope of present patent application can be used for the treatment of diarrhoea, and successful.Known according to the result of table 3, the effect of compound recipe A is the most obvious.
The different compound extract lyophilized powders of table 3. cause the efficacy result of diarrhea mice to escherichia coli
Note:
*relatively there is significant differences with model group.
Embodiment 8: the clinical research of traditional Chinese medicine composition for treating diarrhoea of the present invention
In order to show clinical efficacy of the present invention, we adopt and compare with Western medicine, and research is divided into treatment group (Chinese medicine composition of the present invention) and matched group (smecta group).Enter to organize 80 cases, each 40 examples for the treatment of group and matched group wherein, case enters group with reference to the health industry standard > > WS-2007 < < of < < People's Republic of China (PRC) infectious diarrhea diagnostic criteria > >, with reference to < < new Chinese medicine guideline of clinical investigations > >, the diagnostic criteria of having loose bowels is that cold-damp is main syndrome to tcm diagnosis, clinical manifestation is that cardinal symptom is: have loose bowels rare clearly, very as water sample, the ring of stomachache intestinal, the vexed lack of appetite of gastral cavity, tongue is greasy in vain, relaxed and soft pulse.If hold concurrently affection of exogenous wind-cold, fever with aversion to cold headache, limb aching pain, white and thin fur, floating pulse.Can be with poisoning symptoms such as heating, irritated or drowsiness, nausea and vomiting, borborygmus stomachache.By the simulation of SAS statistical package, produce the table of random numbers again, include exclusion standard in enter to organize case according to research approach, experimenter, according to the priority of including research in, enters treatment group and matched group successively by random number sequence number.Treatment group: adopt traditional Chinese medicine composition for treating of the present invention (take 9 grams of Herba Pogostemoniss, 9 grams of Rhizoma Pinelliae Preparata, 6 grams of the Radix Aucklandiae, 9 grams of Pericarpium Citri Reticulataes, 3 grams of Flos Caryophyllis, 3 grams of Cortex Cinnamomis, 15 grams of Rhizoma Atractylodis, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 15 grams, Poria and 15 grams of Chinese medicine granules of preparing as compound recipe of Fructus Crataegi (parched to brown)), 1 dose of every day, after brewing, drink and minute take for three times.Matched group: dioctahedral smectite treatment, 3 grams/bag, after brewing, drink one time one bag, every day three times.Be two days the course for the treatment of of two groups.According to therapeutic effect, be divided into three types: recovery from illness, it is normal that feces character and number of times recover, and General Symptoms disappears; Effectively, feces character is clearly better and number of times reduces, and General Symptoms obviously improves; Invalid, feces character and General Symptoms even worsen without taking a turn for the better.Effective percentage=(recovery from illness number+efficiently individual quantity)/n * 100% wherein.
Experimental result is in Table 4, and through adopting SPSS 13.0 statistical analysis softwares to carry out statistical procedures, enumeration data adopts χ
2check, ranked data are analyzed with R idit.The promising significant difference of matched group and treatment group (P<0.05).Clinical experiment result shows, Chinese medicine composition of the present invention has significance curative effect to cold-damp diarrhoea, and its effect is than thinking close good effect.
Curative effect comparison between table 4 cold-damp diarrhoea group
Note: relatively have significant difference, P<0.05 with matched group.
Claims (4)
1. a Chinese medicine composition of preventing and treating diarrhoea, is characterized in that, this Chinese medicine composition is comprised of the crude drug of following weight portion:
3～9 parts of Herba Pogostemoniss, 3～9 parts of Rhizoma Pinelliae Preparata, 2～6 parts of the Radix Aucklandiae, 3～9 parts of Pericarpium Citri Reticulataes, 1～3 part of Flos Caryophylli, 1～3 part of Cortex Cinnamomi, 5～15 parts of Rhizoma Atractylodis, 4～12 parts of the Rhizoma Atractylodis Macrocephalaes, 5～15 parts, Poria, 5～15 parts of Fructus Crataegi (parched to brown)s.
2. Chinese medicine composition according to claim 1, is characterized in that, this Chinese medicine composition is comprised of the crude drug of following weight portion:
3 parts of Herba Pogostemoniss, 3 parts of Rhizoma Pinelliae Preparata, 2 parts of the Radix Aucklandiae, 3 parts of Pericarpium Citri Reticulataes, 1 part of Flos Caryophylli, 1 part of Cortex Cinnamomi, 5 parts of Rhizoma Atractylodis, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Poria, 5 parts of Fructus Crataegi (parched to brown)s.
3. the application of Chinese medicine composition according to claim 1 in the medicine of preparation control diarrhoea.
4. application according to claim 3, is characterized in that, the medicine of described control diarrhoea is the medicine of preventing and treating cold-damp diarrhoea.
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| CN105193918A (en) * | 2015-10-09 | 2015-12-30 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition used for treating non-infectious diarrhea of cage rearing chicken as well as preparation method and application thereof |
| CN106421686A (en) * | 2016-08-30 | 2017-02-22 | 山东省文登整骨医院 | Traditional Chinese medicine navel plaster for treatment of cold-damp diarrhea |
| CN106620398A (en) * | 2017-03-01 | 2017-05-10 | 濮阳市医和堂药业有限公司 | Diarrhea-checking plaster prepared from traditional Chinese medicine composition and preparation method of diarrhea-checking plaster |
| CN109700921A (en) * | 2019-03-07 | 2019-05-03 | 张春梅 | Replenish qi to invigorate the spleen external application type Traditional Chinese medicine composition patch, preparation and its application of appetizing |
| CN113521212A (en) * | 2021-07-26 | 2021-10-22 | 河北科为先生物科技有限公司 | Fermented traditional Chinese medicine composition for strengthening spleen and stomach and balancing poultry intestinal flora |
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| CN104013756B (en) | 2017-10-31 |
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