CN104013756B - A kind of Chinese medicine composition for preventing and treating diarrhoea and application thereof - Google Patents
A kind of Chinese medicine composition for preventing and treating diarrhoea and application thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for preventing and treating diarrhoea, it is made up of following raw material medicine：3~9 parts of wrinkled giant hyssop, 3~9 parts of the tuber of pinellia processed, 2~6 parts of the banksia rose, 3~9 parts of dried orange peel, 1~3 part of cloves, 1~3 part of Chinese cassia tree, 5~15 parts of rhizoma atractylodis, 4~12 parts of the bighead atractylodes rhizome, 5~15 parts of Poria cocos, 5~15 parts of charred FRUCTUS CRATAEGI.In addition, being used for the application for preparing prevention and treatment traditional Chinese medical science cold-damp anti-diarrhea drug the invention also discloses the Chinese medicine composition.The present invention shows that security is good, and curative effect is good through experimental animal and clinical test card, can effectively treat traditional Chinese medical science cold-damp diarrhoea.Said composition is that a kind of improvement clinical symptoms effect is good, and toxic side effect is small, the herbal mixture with good potential applicability in clinical practice.
Description
Technical field
The invention belongs to technical field of Chinese medicine, it is related in a kind of Chinese medicine composition, more particularly to a kind of preventing and treating diarrhoea
Drug composition.
Background technology
Diarrhoea is both a kind of independent disease, is a kind of disease in a variety of disease pathology processes again as common clinical
Shape.Statistics shows that China has 8.36 hundred million person-times to suffer from diarrhoea every year.Therefore, the Ministry of Public Health is classified as diarrhoea the disease of China's keypoint control
One of disease.Diarrhoea can be divided into infectious and non-infectious two kinds according to the cause of disease.Wherein infectious diarrhea disease is by pathogenic microorganism
And its be the important public affairs in the current whole world to suffer from diarrhoea as one group of enteric infectious disease of main clinical manifestation caused by product or parasite
One of common hygienic issues.China's law on the prevention and control of infectious diseases will remove cholera (category A infectious disease), dysentery, Typhoid and paratyphoid within 1989
Suffered from diarrhoea caused by microorganism beyond (Category B notifiable disease), be referred to as " other infectious diarrheas disease ", be listed as Class C infectious disease.
The incidence of disease of China occupies the prostatitis of Class C infectious disease, according to People's Republic of China's national health and Family Planning Committee
Statistics display in 2012：In the Class C infectious disease of national statutory report, other venereal infection incidences of disease occupy second, report other
Infectious diarrhea case amounts to 885678, wherein dead 17.In the Class C infectious disease incidence number of in January, 2014 whole nation report
Other infectious diarrhea diseases hold pride of place.
Although to the treatments of various infectious diarrheas as the popularization of fluid replacement therapy and the raising of whole medical treatment level have
Great progress, but with the abuse of clinically antibiotic, accelerate the generation of enteric pathogenic bacteria drug resistance, brought to clinical treatment
It is difficult.Because the preventing and treating of the infectious diarrhea of new hair burst is still arduous, and the traditional Chinese medical science payes attention to the entirety of people, exquisite dialectical, emphasizes
Adjust in body the growth and decline change in vivo of resistance against diseases and evil positive both sides.Therefore for some neopathies because not clear
Infectious diarrhea, the traditional Chinese medical science can symptomatic treatment, the combination of many methods, comprehensive collaboration in dialectical basis, early stage is realized to disease
Intervene, mitigate patient symptom, weaken infringement of the pathogen toxin to viscera organ, with significant curative effect.
Presently disclosed document report《Plus taste gegen qinlian decoction treatment damp-heat acute diarrhoea observation of curative effect》(the Heilungkiang traditional Chinese medical science
Medicine, the 2nd 14-15 pages of phase in 2009) with adding in taste gegen qinlian decoction side with having wrinkled giant hyssop and Poria cocos, it is mainly used in treatment damp and hot
Type acute diarrhea, the indication difference with we.Presently disclosed document report《Warm intestines anti-diarrhea medicinal powder navel-applying therapeutic children's colyliform
The clinical research of viral enteritis (cold-dampness type)》(Shandong Traditional Chinese Medicine University, 2012 Master's thesis) are (grey with warm intestines anti-diarrhea medicinal powder
Art, notopterygium root, Chinese cassia tree, according to 3:2:1 ratio grinds to the powder to be sieved through and mixed, and is tuned into thick paste with ginger juice and water dilution and then spreads on
SHENQUE acupoint, is persistently applied 8 hours in daily 7AM to 3PM, and daily dressing is once) navel-applying therapeutic cold-dampness type infant rotaviral
Enteritis, although the rhizoma atractylodis mentioned in side with Chinese medicine composition of the present invention and Chinese cassia tree, with Chinese medicine composition difference of the present invention
Very big, its prescription mechanism is also different.Presently disclosed document report《Plus taste baitouweng decoction treatment children bacillary dysentery 180》(river
Revive traditional Chinese medicine magazine, also with there is the banksia rose in the 1st phase in 2001 sides of page 45, but other medications and Chinese medicine composition of the present invention are poor
Very not big, comparativity is not strong.The Chinese medicine of the compound combination in we is reported in document, with other medicine conjunctive use ability tables
Existing certain effect for controlling diarrhoea, but it is inconsistent with the Chinese medicine described by Chinese medicine composition of the present invention, and this combination is sieve
Kinds of traditional Chinese medicines is selected to find that this composition is organically combined according to a certain percentage after combining, it prevents and treats cold-damp diarrhoea work
With more preferably, it is to play a part of synergy as an entirety, has played the curative effect that each single medicinal material can not embody.It is existing
There is document and publication there are no and be suffered from diarrhoea on the cold-damp of said composition, it is creative.
The content of the invention
One of the technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for preventing and treating diarrhoea.
The second technical problem to be solved by the present invention is to provide a kind of purposes of the Chinese medicine composition.
In one aspect of the invention there is provided a kind of Chinese medicine composition for preventing and treating diarrhoea, by the bulk drug group of following parts by weight
Into：3~9 parts of wrinkled giant hyssop, 3~9 parts of the tuber of pinellia processed, 2~6 parts of the banksia rose, 3~9 parts of dried orange peel, 1~3 part of cloves, 1~3 part of Chinese cassia tree, rhizoma atractylodis 5
5~15 parts of~15 parts, 4~12 parts of the bighead atractylodes rhizome, 5~15 parts of Poria cocos and charred FRUCTUS CRATAEGI.Wherein, weight preferably is：Wrinkled giant hyssop 3
Part, 3 parts of the tuber of pinellia processed, 2 parts of the banksia rose, 3 parts of dried orange peel, 1 part of cloves, 1 part of Chinese cassia tree, 5 parts of rhizoma atractylodis, 4 parts of the bighead atractylodes rhizome, 5 parts of Poria cocos, charred FRUCTUS CRATAEGI 5
Part.
Chinese medicine composition of the present invention is the leaves of pulse plants in the effective Chinese medicine compound prescription of clinical application according to theory of traditional Chinese medical science reasonable formula, side
Perfume (or spice) can gas soon, and in, ward off dirty, eliminating dampness to stop diarrhea；It is cold to dissipate belly that Chinese cassia tree and cloves share energy complement sun, middle benefit gas；Rhizoma atractylodis and white
Art energy strengthening the spleen and stomach eliminating dampness, in conjunction with Poria cocos with bowl spares invigorating the spleen, controls the diarrhea of the insufficiency of the spleen with overabundance of dampness；And the gas of banksia rose benefaction stomach and intestine and stop
Bitterly, tuber of pinellia eliminating dampness preventing or arresting vomiting processed is equipped with, is alleviated because of the stomachache caused by damp evil diarrhea and vomiting；Again to focus hawthorn digesting with antidiarrheal.
Perfect square combination can dispelling cold and dehumidification, warming spleen and stopping diarrha, thin for diarrhea to clinical manifestation for cold-dampness diarrhea, such as water sample, intestines of suffering from abdominal pain
Ring, the vexed deficiency of food of gastral cavity can have good efficacy with poisoning symptoms such as heating, nausea and vomiting, borborygmus stomachache.We are to be based on middle medical knowledge
It is an organic whole, the performance of its curative effect is nor a composition or certain a herb institute can be completely by the compound of guidance
Substitute, and experimental study shows, and we are optimal as its curative effect during an entirety, have significantly than simple using effect
Synergy is acted on.
Chinese medicine composition of the present invention can be pressed after direct or extracted processing with pharmaceutically acceptable pharmaceutical carrier
The conventional method of this area be made various oral medicinal herb conventional doses be used for prevent and treat suffer from diarrhoea in.Described extraction processing work
Skill, can use Traditional Chinese medicine extraction method known in the art, such as, but not limited to solvent extraction method, steam distillation, liter
Hua Fa, supercritical extraction etc..
Described pharmaceutical dosage forms can be any pharmaceutically useful formulation, and these formulations include：Tablet, sugar coated tablet,
Film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, mouth containing agent, granule, electuary, ball
Agent, powder, paste, sublimed preparation, supensoid agent, pulvis, solution, injection, suppository, ointment, emplastrum, creme, spray,
Drops, patch；It is preferred that peroral dosage form, such as：Capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, paste etc..Institute
The peroral dosage form stated can containing conventional excipient, such as adhesive, filler, diluent, tablet agent, lubricant, disintegrant,
Colouring agent, flavor enhancement and wetting agent, can be coated to tablet if necessary.Suitable filler include cellulose, mannitol,
Lactose and other similar fillers；Suitable disintegrant includes starch, polyvinylpyrrolidone and starch derivatives, such as hydroxyl
Guanidine-acetic acid sodium starch；Suitable lubricant includes, for example magnesium stearate.Suitable pharmaceutically acceptable wetting agent includes dodecane
Base sodium sulphate etc..
The second aspect of the present invention there is provided application of the Chinese medicine composition in the medicine for preparing preventing and treating diarrhoea, special
It is not the application in the medicine for preventing and treating cold-damp diarrhoea is prepared.Traditional Chinese medical science cold-damp is suffered from diarrhoea, and clinical manifestation is that diarrhea is thin, very such as
Water sample, borborygmus of suffering from abdominal pain, the vexed deficiency of food of gastral cavity can be with poisoning symptoms such as heating, nausea and vomiting, borborygmus stomachache.
Results of animal proves that Chinese medicine composition of the present invention has the effect of obvious treatment diarrhoea, and certain independent
The effect of medicine does not reach the effect that the Chinese medicine composition is used in conjunction with simply, and the Synergistic for embodying each group subassembly is made
With.Clinical trial results show that Chinese medicine composition of the present invention has conspicuousness curative effect to cold-damp diarrhoea, and its effect is than control Western medicine
Think close better efficacy.The present invention shows that security is good, and curative effect is good, in effectively treating through experimental animal and clinical test card
Cold-damp diarrhoea is cured, said composition is that a kind of improvement clinical symptoms effect is good, and toxic side effect is small, before good clinical practice
The herbal mixture of scape.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.The experimental method of unreceipted actual conditions in the following example, generally according to conventional strip
Part or according to the condition proposed by manufacturer.Unless otherwise indicated, otherwise all percentage, ratio, ratio or number is pressed
Weight meter.
Embodiment 1：Oral liquid
Raw material is taken by following weight proportion：300 grams of wrinkled giant hyssop, 300 grams of the tuber of pinellia processed, 200 grams of the banksia rose, 300 grams of dried orange peel, cloves
100 grams, 100 grams of Chinese cassia tree, 500 grams of rhizoma atractylodis, 400 grams of the bighead atractylodes rhizome, 500 grams of Poria cocos, 500 grams of charred FRUCTUS CRATAEGI.The taste of the above ten adds water to cook 2
Secondary, from boiling timing, 1 hour every time, 10 times of amount water, added 8 times of amount water, after decoction is finished, merging is decocted twice for the second time for the first time
Boil liquid, lets cool 3000rpm and centrifuges 10 minutes, remove supernatant, concentrate, add proper auxiliary materials, mouth is made according to existing known help
Liquid 1L is taken, dispenses, produces by every bottle of 10ml, it is daily oral 3 times, every time 1 bottle.
Embodiment 2：Granule
Raw material is taken by following weight proportion：3000 grams of wrinkled giant hyssop, 3000 grams of the tuber of pinellia processed, 2000 grams of the banksia rose, 3000 grams of dried orange peel, fourth
Fragrant 1000 grams, 1000 grams of Chinese cassia tree, 5000 grams of rhizoma atractylodis, 4000 grams of the bighead atractylodes rhizome, 5000 grams of Poria cocos, 5000 grams of charred FRUCTUS CRATAEGI.The above ten is simply
Add water to cook 2 times, from boiling timing, 1 hour every time, 10 times of amount water, second plus 8 times of amount water, after decoction is finished, were closed for the first time
And decoction liquor twice, let cool 3000rpm and centrifuge 10 minutes, remove supernatant, be concentrated into the medicinal extract that proportion is 1.35, plus appropriate dextrin
And Icing Sugar, after 70 DEG C are dried, particle 5000g granulations are made, dispenses, produces by every bag of 5g, it is daily oral 3 times, every time 1 bag.
Embodiment 3：Tablet
Raw material is taken by following weight proportion：3000 grams of wrinkled giant hyssop, 3000 grams of the tuber of pinellia processed, 2000 grams of the banksia rose, 3000 grams of dried orange peel, fourth
Fragrant 1000 grams, 1000 grams of Chinese cassia tree, 5000 grams of rhizoma atractylodis, 4000 grams of the bighead atractylodes rhizome, 5000 grams of Poria cocos, 5000 grams of charred FRUCTUS CRATAEGI.The above ten is simply
Add water to cook 2 times, from boiling timing, 1 hour every time, 10 times of amount water, second plus 8 times of amount water, after decoction is finished, were closed for the first time
And decoction liquor twice, let cool 3000rpm and centrifuge 10 minutes, take supernatant, subtract and be concentrated into dry cream, then by known in the art
Tablet is made in method, and every 0.3 gram, daily oral 3 times, 3 tablets once.
Embodiment 4：Capsule
The five kinds of Traditional Chinese medicine compound composition weight proportions for treating diarrhoea provided by table 1 weigh raw material, separately constitute compound
A, Compound B, compound C, compound D, five kinds of Traditional Chinese medicine compound compositions of compound E, its formula table are shown in Table in 1, table 1, every part of consumption 100
Gram.Respectively plus suitable quantity of water is decocted 2 times, from boiling timing, 1 hour every time, after decoction is finished, merge decoction liquor twice, depressurize dense
Contracting, then be freeze-dried to freeze-dried powder, it is standby as composition freeze-dried powder.Capsule is made by method known in the art again,
It is 0.3 gram every, daily oral 3 times, every time 3.
1. 5 kinds of table treats the Traditional Chinese medicine compound composition table of diarrhoea
Embodiment 5：Decoction liquor
Raw material is taken by following weight proportion：9 grams of wrinkled giant hyssop, 9 grams of the tuber of pinellia processed, 6 grams of the banksia rose, 9 grams of dried orange peel, 3 grams of cloves, Chinese cassia tree 3
Gram, 15 grams of rhizoma atractylodis, 12 grams of the bighead atractylodes rhizome, 15 grams of Poria cocos and 15 grams of charred FRUCTUS CRATAEGI.Plus suitable quantity of water is decocted 2 times, from boiling timing, 1 is small every time
When, after decoction is finished, merge decoction liquor twice, instructions of taking is：Taken in two times in one day.
Embodiment 6：Chinese medicine composition of the present invention and comparative studies of each single medicine body to diarrhea mice curative effect
Raw material is taken by following weight proportion：90 grams of wrinkled giant hyssop, 90 grams of the tuber of pinellia processed, 60 grams of the banksia rose, 90 grams of dried orange peel, 30 grams of cloves,
150 grams of 30 grams of Chinese cassia tree, 150 grams of rhizoma atractylodis, 120 grams of the bighead atractylodes rhizome, 150 grams of Poria cocos and charred FRUCTUS CRATAEGI.Plus suitable quantity of water is decocted 2 times, from boiling meter
When, 1 hour every time, after decoction is finished, merge decoction liquor twice, be concentrated under reduced pressure, then be freeze-dried to freeze-dried powder, it is used as composition
Freeze-dried powder (ZHW) is standby, and other each simples are taken in composition to be measured accordingly, by preparation method of composition, after decocting and concentrating
Freeze-dried powder is made, wrinkled giant hyssop freeze-dried powder (HX), tuber of pinellia freeze-dried powder processed (ZBX), banksia rose freeze-dried powder (MX), dried orange peel freeze-dried powder are made respectively
(CP), cloves freeze-dried powder (DX), Chinese cassia tree freeze-dried powder (RG), rhizoma atractylodis freeze-dried powder (CZ), bighead atractylodes rhizome freeze-dried powder (BZ), Poria cocos freeze-dried powder
(FL), charred FRUCTUS CRATAEGI freeze-dried powder (JSZ), standby.
From Kunming mouse 60,13 groups, every group 10 are randomly divided into；If blank group, model group, positive drug group (are thought
It is close to reach), each medicine group (ZHW groups, HX groups, ZBX groups, MX groups, CP groups, DX groups, RG groups, CZ groups, BZ groups, FL groups and JSZ groups).Remove
Outside blank group, remaining group animal is injected intraperitoneally Escherichia coli bacteria liquid (0.3ml/10g) and causes severe diarrhea model, blank group abdomen
Chamber injects normal saline.After 3 hours, blank group and model group mouse stomach physiological saline；Treatment group's mouse each group administration
Dosage is respectively 50mg/kg；Positive controls dioctahedral smectite dosage is 20mg/kg.After experiment starts, observation intraperitoneal injection large intestine
Model group and each treatment group, positive controls diarrhea of mouse feelings in 3h after diarrhea of mouse situation and administration in bacillus parenteral solution 3h
Condition (including loose stools number of times, total bowel frequency number, loose stools level), and calculate Scours index.Observed content：(1) general state of mouse
Change with behaviouristics：The state of mind, figure's fur, diet situation, the change of stool.(2) measure of Scours index:Count loose stools
Number of times, total bowel frequency number, loose stools level, calculate Scours index.
Test result indicates that, there is different degrees of diarrhoea after 1 hour in intraperitoneal injection Escherichia coli bacteria liquid, shows as bowel frequency
Increase, just matter it is dilute it is soft, substantially aggravate to the 3rd hour diarrhoea situation, some mouse are in obvious lassitude hypodynamia, One's spirits are drooping,
Dilute watery stool.After drug therapy, the diarrhea of mouse symptom of positive drug group and the administration of ZHW groups is obviously improved, and is shown as stool number and is subtracted
Few, just matter is become a cadre by dilute, and the state of mind is gradually good, and diet recovers, and mood is slightly shown in excitement.The symptom that other administration groups have has more
Be obviously improved, some symptoms improves unobvious, its therapeutic effect with ZHW groups there were significant differences (P<0.01) combination, is not reached
The therapeutic effect of thing, main result is shown in Table 2.Test result indicates that, Chinese medicine composition of the present invention has obvious treatment diarrhoea
Effect, and the effect of independent certain medicine simply does not reach the effect that composition is used in conjunction with.
The different compound extract freeze-dried powders of table 2. cause the influence of the curative effect of diarrhea mice to Escherichia coli
Note：**Relatively there are significant differences, P with model group<0.01；##Being compared with ZHW groups has significant differences, P
<0.01。
Embodiment 7：Comparative studies of the different ratio Chinese medicine composition of the present invention to diarrhea mice curative effect
Take that " five kinds of compound A, Compound B, compound C, compound D, compound E freeze-dried powders prepared by embodiment 4 " are as experiment pair
As according to " embodiment 6 " investigates the treatment of the composition of different ratio using the mouse that Escherichia coli bacteria liquid modeling is injected intraperitoneally
The effect of infectious diarrhea.Compared with model group, different ratio composition group is substantially less than model group P<0.01, and each proportioning group
Between there was no significant difference.It the results are shown in Table 3.Test result indicates that, treatment is suffered from diarrhoea according to the different ratio of the present composition
There are significant curative effect, that is, treatment of the proportioning available for diarrhoea in the range of present patent application, and effect is obvious.According to
The result of table 3 understands that compound A effect is most obvious.
The different compound extract freeze-dried powders of table 3. cause the efficacy result of diarrhea mice to Escherichia coli
Note：**Being compared with model group has significant differences.
Embodiment 8：The clinical research of traditional Chinese medicine composition for treating diarrhoea of the present invention
In order to show the clinical efficacy of the present invention, we use is compared with Western medicine, and research is divided into treatment group (in the present invention
Drug composition) and control group (smecta group).Enter a group 80 cases, wherein each 40 for the treatment of group and control group, case enters a group ginseng
According to《People's Republic of China's health industry standard》WS-2007《Infectious diarrhea diagnostic criteria》, tcm diagnosis then reference《Chinese medicine
Clinical Researches of New Drugs guideline》Diarrhea diagnostic criteria is the syndrome based on cold-dampness, and clinical manifestation is that cardinal symptom is：Diarrhea is clear
Dilute, very such as water sample, borborygmus of suffering from abdominal pain, the vexed deficiency of food of gastral cavity, tongue is greasy in vain, soft and moderate pulse.If simultaneous catch cold, fever with aversion to cold headache, limbs
Ache, tongue is thin white, floating pulse.Can be with poisoning symptoms such as heating, irritated or drowsiness, nausea and vomiting, borborygmus stomachache.United again by SAS
Count software kit simulation and produce the table of random numbers, including exclusion standard according to research approach enters a group case, subject is according to including research
Priority, sequentially enter treatment group and control group by random number sequence number.Treatment group：Use traditional Chinese medicine composition for treating of the present invention (with
9 grams of wrinkled giant hyssop, 9 grams of the tuber of pinellia processed, 6 grams of the banksia rose, 9 grams of dried orange peel, 3 grams of cloves, 3 grams of Chinese cassia tree, 15 grams of rhizoma atractylodis, 12 grams of the bighead atractylodes rhizome, 15 grams of Poria cocos
With 15 grams of Chinese herbal granules for compound preparation of charred FRUCTUS CRATAEGI), daily 1 dose, drink and take in three times after brewing.Control group：Think close
Up to treatment, 3 grams/bag, drunk after brewing, one time one bag, three times a day.Two groups of the course for the treatment of is two days.According to therapeutic effect point
For three types：Recovery from illness, fecal character and number of times recover normal, and constitutional symptom disappears；Effectively, fecal character is clearly better and secondary
Number is reduced, and constitutional symptom is obviously improved；Invalid, fecal character and constitutional symptom even deteriorate without taking a turn for the better.It is wherein efficient=(to fully recover from an illness
More number+efficiently individual quantity)/n × 100%.
Experimental result is shown in Table 4, and through carrying out statistical procedures using the statistical analysis softwares of SPSS 13.0, enumeration data is used
χ2Examine, ranked data are analyzed with R idit.Control group and the promising significant difference (P for the treatment of group<0.05).Clinical trial results
Show, Chinese medicine composition of the present invention has conspicuousness curative effect to cold-damp diarrhoea, and its effect is than thinking close good effect.
Comparitive study between the cold-damp diarrhoea group of table 4
Note：Being compared with control group has significant difference, P<0.05.
Claims (4)
1. it is a kind of prevent and treat diarrhoea Chinese medicine composition, it is characterised in that the Chinese medicine composition by following parts by weight bulk drug group
Into：
3~9 parts of wrinkled giant hyssop, 3~9 parts of the tuber of pinellia processed, 2~6 parts of the banksia rose, 3~9 parts of dried orange peel, 1~3 part of cloves, 1~3 part of Chinese cassia tree, rhizoma atractylodis 5
~15 parts, 4~12 parts of the bighead atractylodes rhizome, 5~15 parts of Poria cocos, 5~15 parts of charred FRUCTUS CRATAEGI.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition by following parts by weight raw material
Medicine is constituted：
3 parts of wrinkled giant hyssop, 3 parts of the tuber of pinellia processed, 2 parts of the banksia rose, 3 parts of dried orange peel, 1 part of cloves, 1 part of Chinese cassia tree, 5 parts of rhizoma atractylodis, 4 parts of the bighead atractylodes rhizome, Poria cocos 5
Part, 5 parts of charred FRUCTUS CRATAEGI.
3. application of the Chinese medicine composition according to claim 1 in the medicine for preparing preventing and treating diarrhoea.
4. application according to claim 3, it is characterised in that the medicine of the preventing and treating diarrhoea is to prevent and treat what cold-damp was suffered from diarrhoea
Medicine.
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| CN105193918A (en) * | 2015-10-09 | 2015-12-30 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition used for treating non-infectious diarrhea of cage rearing chicken as well as preparation method and application thereof |
| CN106421686A (en) * | 2016-08-30 | 2017-02-22 | 山东省文登整骨医院 | Traditional Chinese medicine navel plaster for treatment of cold-damp diarrhea |
| CN106620398A (en) * | 2017-03-01 | 2017-05-10 | 濮阳市医和堂药业有限公司 | Diarrhea-checking plaster prepared from traditional Chinese medicine composition and preparation method of diarrhea-checking plaster |
| CN109700921A (en) * | 2019-03-07 | 2019-05-03 | 张春梅 | Replenish qi to invigorate the spleen external application type Traditional Chinese medicine composition patch, preparation and its application of appetizing |
| CN113521212A (en) * | 2021-07-26 | 2021-10-22 | 河北科为先生物科技有限公司 | Fermented traditional Chinese medicine composition for strengthening spleen and stomach and balancing poultry intestinal flora |
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| CN1899379A (en) * | 2006-07-14 | 2007-01-24 | 左耀武 | External plaster for treating child cold diarrhea and preparing method |
| CN102319412A (en) * | 2011-09-27 | 2012-01-18 | 解连新 | Traditional Chinese medicine used for treating diarrhea |
| CN103495082A (en) * | 2013-09-17 | 2014-01-08 | 王学岭 | Internal-external extract and pellets for treating infantile diarrhea |
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| CN1092314A (en) * | 1993-03-13 | 1994-09-21 | 邢春生 | Treatment diarrheal Chinese medicine for outer use |
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