CN103055111B - Traditional Chinese medicine composition for treating children's infantile malnutrition and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating children's infantile malnutrition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating children's infantile malnutrition and a preparation method thereof. The traditional Chinese medicine composition comprises the following traditional Chinese medicines by weight: 50 to 250 parts of fried cape jasmine fruit, 50 to 250 parts of saltcake, 50 to 250 parts of bitter apricot kernel, 50 to 250 parts of Chinese prickly ash and 10 to 100 parts of fistular onion stalk. Test results show that the traditional Chinese medicine composition provided by the invention has a therapeutic effect on patient children with a slim body, dysphoria, frequent crying, thirst and body heat caused by infantile malnutrition and the therapeutic effect is obviously superior to that of the prior art.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of infantile malnutrition and preparation method thereof.
Background technology
Infantile malnutrition taking god wither, the large muscle of emaciation and sallow complexion, brittle hair, tripe reveals, indigestion and loss of appetite loose stool is as the child disease of main manifestations.Be more common in 1～5 years old child.How because of eating and drinking without temperance, breast food improper feeding, impairing the spleen and stomach, transformation failure of spleen, undernutrition, QI and blood is precise and tiny can not moisten foster internal organs; Or because of diseases such as chronic diarrhea, chronic dysentery, Enterozoas, prolongedly do not heal, impairing the spleen and stomachs etc. cause a kind of chronic disease of malabsorption.
" infantile malnutrition " but in modern times has a marked difference with former said it " infantile malnutrition ", in the past due to the restriction of living standard, people are usually hungry full uneven, to children's's feeding deficiency, make to lose and raw infantile malnutrition in taste, how to be caused by malnutrition, be namely equivalent to " malnutrition " that doctor trained in Western medicine is said.And the present raising along with people's living standard, and only child increases recently, and the heads of a family lack again feeding knowledge, strengthen blindly nutrition, the load that has increased the weight of on the contrary spleen fortune, has injured QI of the spleen and stomach, stagnant long-pending middle burnt, appetite is declined, and malnutrition, is caused by nutrient imbalance therefore present infantile malnutrition is many.Two two kinds, the types that lose of clinical common deficiency of the spleen causing weakness of QI type and QI and blood.Primary disease onset is slow, course of disease delay, and state of an illness complexity, has a strong impact on children's upgrowth and development, very threat to life.
At present, doctor trained in Western medicine is classified as malnutrition infantile malnutrition, and clinical treatment mainly relies on the abundant food vitaminize B of vitimin supplement and intramuscular injection nandrolone phenylpropionate.The treatment power of doctor trained in Western medicine is being improved symptom, not from improve patient's body constitution at all, and treatment disease.
Not obvious for western medicine effect, therefore, Chinese medicine preparation approved by the numerous heads of a family aspect infantile malnutrition in treatment, as:
Be used for the treatment of gastropathy due to Deficiency and coldness of spleen and stomach, if Chinese Patent Application No. is 92111735.3, publication number is that the patent of invention of CN1085782 discloses a kind of prescriptions of Chinese medicine for the treatment of infantile malnutrition, have oral and two kinds of prescriptions of external application use, oral prescription is the compositions such as Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae, Chrysomyiame gacephala (Fab.), Radix Ginseng, Fructus Amomi, Fructus Hordei Germinatus, Placenta Hominis, Os Draconis, pollen, charcoal short, bristly hair or beard, Endothelium Corneum Gigeriae Galli, male power, Semen Coicis, the Radix Paeoniae Alba, Fructus Rubi, Semen Euryales, Os Tigris, Hunan Bufo siccus, Rhizomadioscoreae, Poria cum Radix Pini, the Radix Astragali, Jin Yingzi, Faeces Vespertilionis, Semen Arecae; Application compress prescriptions is: Radix Angelicae Sinensis, the Radix Aucklandiae, Mirabilitum, borneol, Rhizoma Chuanxiong, Folium Artemisiae Argyi, Indigo Naturalis, Flos Carthami, lead to muscle, Rhizoma Acori Graminei, mandarin orange leaf brill, practice hard the compositions such as root bark.This prescription prescription complexity, the more difficult acquisition of multi-flavor medicine, and the flavour of a drug that have have certain toxicity, and the curative effect of this prescribed treatment infantile malnutrition and safety inspection need further checking.Except, also have dietetic therapy, massage, chiropractic, choose the Therapeutic Method such as infantile malnutrition, but all the course for the treatment of longer, onset is slow, also comparatively painful disadvantage of hordeolum therapy.
CN95100102.7 relates to one and is used for the treatment of infantile malnutrition (being GANJI SAN), also can be used for infantile anorexia, dyspepsia, agitation is cryed, sleep night not peaceful, eating and drinking without temperance, eating cold and uncooked food excessively or medicine and preparation technology because of diseases such as the abdominal distention due to being affected by the cold, stomachache, diarrhoea.Health-care adhesive plaster for removing food stagnancy for children is mainly by Chinese medicine Fructus Gardeniae 30-40%, Flos Caryophylli 4%, Semen Armeniacae Amarum 13-23%, Radix orixae japonicae, Bulbus Allii Fistulosi, and ethyl hydroxybenzoate.
Separately have experience side's GANJI SAN, be made up of Flos Caryophylli, Semen Armeniacae Amarum, Pericarpium Zanthoxyli, Fructus Gardeniae (parched) equal portions, this prescription is lighter, really effective for stagnant symptom, just can not deal with problems if still stagnant heavier.Infantile malnutrition is tangible breast food inner product, and the method for non-food stagnation removing can not be gone, and the method for food stagnation removing must be with internal diabetes breast removing food stagnancy, with stagnant the combining of admittance of sending down the abnormal ascending QI.Flos Caryophylli, a Fructus Piperis two tastes tool warming spleen and stomach for dispelling cold for this prescription, the use of stop asthenia cold abdominalgia, vomitting, having loose bowels, food stagnation removing ability is not good enough.
The most prescription of existing compound Chinese medicinal preparation treatment infantile malnutrition is huge, and the many and a lot of medical materials of flavour of a drug are rareer, and oral preparations, and child administration gets up more difficult.Minority prescription is little, but drug effect is looked into.
In order to overcome the shortcoming of prior art, inventor has carried out a large amount of research, finally determines the present invention.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of infantile malnutrition.
Another object of the present invention is to provide the preparation method of described Chinese medicine composition.
One provided by the invention is treated infantile malnutrition Chinese medicine composition, contains the Chinese medicine with following weight proportion: Fructus Gardeniae (parched) 50-250 part, Natrii Sulfas 50-250 part, Semen Armeniacae Amarum 50-250 part, Pericarpium Zanthoxyli 50-250 part, Bulbus Allii Fistulosi 10-100 part.
Preferably, the Chinese medicine that described Chinese medicine composition contains following weight portion: Fructus Gardeniae (parched) 150-200 part, Natrii Sulfas 150-200 part, Semen Armeniacae Amarum 150-200 part, Pericarpium Zanthoxyli 150-200 part, Bulbus Allii Fistulosi 50-75 part.
Further preferably, the Chinese medicine that described Chinese medicine composition contains following weight portion: 150 parts of Fructus Gardeniae (parched), 150 parts, Natrii Sulfas, 150 parts of Semen Armeniacae Amarums, 150 parts, Pericarpium Zanthoxyli, 50 parts of Bulbus Allii Fistulosi.
In above-mentioned Chinese medicine composition:
Described Bulbus Allii Fistulosi is the bulb of the nearly root of liliaceous plant Herba Alii fistulosi Allium fistulosumL..
The present invention also provides the method for the above-mentioned Chinese medicine composition of preparation, and the method comprises the steps:
Take each composition according to proportioning, except Bulbus Allii Fistulosi, all the other four taste Chinese medicine powders are broken into coarse powder, add the Bulbus Allii Fistulosi of smashing to pieces, pulverize, and oven drying at low temperature, to obtain final product.
In said method:
The particle size range of described coarse powder is 850-250 μ m, and preferably, described particle size range is 350-500 μ m;
The described particle size range of pulverizing after the Bulbus Allii Fistulosi of smashing to pieces that adds is 150-500 μ m, is preferably 250-500 μ m;
After oven drying at low temperature, also comprise the step of pulverizing, its particle size range is 250-500 μ m, is preferably 350-500 μ m.
The present invention also provides the preparation containing above-mentioned Chinese medicine composition, and said preparation is made up separately of Chinese medicine composition or is made up of Chinese medicine composition and pharmaceutically acceptable carrier.
Described preparation is the conventional various dosage forms in this area, as powder, patch, ointment etc.
Described pharmaceutically acceptable carrier is glycerol, gelatin, starch, stearic acid, triethanolamine, cellulose derivative, polyvinyl alcohol, liquid Paraffin, ethyl hydroxybenzoate, vaseline, lanoline etc.
The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment infantile malnutrition, is mainly used in face Huang Shaohua, and health is become thin, irritated crowing, uneasy sleeping at night, inappetence, abdominal part distension, thirsty, body heat more.Red tongue, greasy fur, slippery and rapid pulse person.
Chinese medicine composition provided by the invention has the following advantages:
1, differential diagnosis in tcm is thought: the pathogenesis of infantile malnutrition is mainly taste imbalances, due to deficiency of both QI and blood.In Chinese medicine composition provided by the invention:
Fructus Gardeniae: bitter, cold, GUIXIN lung tri-jiao channel.Energy clearind deficient heat, diuresis, pathogenic fire purging, removing heat from blood, relieving restlessness;
Natrii Sulfas: salty, bitter, cold.Return stomach, large intestine channel, relieving constipation by purgation, moistening for dryness and softening hard mass.And keep and do not walk, without satiny fraud;
Semen Armeniacae Amarum: hardship, tepor, returns lung, large intestine channel, can fall apart and can fall, effect of tool expelling pathogenic factors from muscles, loose wind, loosening bowel to relieve constipation, sending down the abnormal ascending QI, removing food stagnancy.
Pericarpium Zanthoxyli: pungent, warm, return spleen, stomach, kidney channel, fragrant stomach invigorating, warming middle-JIAO, pain relieving.Bulbus Allii Fistulosi taste fragrance, activates yang into stomach warp.
All medicines share, and play altogether hard masses softening and resolving, consumer product dredge stasis, and warming YANG helps the merit of fortune spleen invigorating.When use, be in harmonious proportion and be affixed on umbilicus eye with yellow wine, within 24 hours, change subsides, medicine can absorb by umbilicus eye, stimulates the menstrual flow and passes through network and act on whole body, makes that taste are strong, QI and blood must be as a means of life.
2, prior art health-care adhesive plaster for removing food stagnancy for children as disclosed in CN95100102.7 is mainly by Chinese medicine Fructus Gardeniae 30-40%, Flos Caryophylli 4%, Semen Armeniacae Amarum 13-23%, Radix orixae japonicae, Bulbus Allii Fistulosi, and ethyl hydroxybenzoate.
Compared with prior art, difference of the present invention is: replaced Flos Caryophylli, Radix orixae japonicae with Natrii Sulfas, Pericarpium Zanthoxyli, for the feature of infantile malnutrition, the viewpoint of " the necessary intestinal stasis relieving of removing food stagnancy; intestinal stasis relieving is double heat clearing away often " is followed in clinical application, Pericarpium Zanthoxyli fragrance stomach invigorating for one side, and promotion gastric stagnates and digests, stopping eating of using on the other hand that Natrii Sulfas can moisten that the effect that can rush down makes to digest makes under it becomes, to get rid of external by the method for intestinal stasis relieving catharsis.
3, result of the test explanation: Chinese medicine composition provided by the invention is become thin at treatment infantile malnutrition health, irritated crowing, truly have curative effect, and successful is better than prior art when the infant of thirsty, body heat more.
Detailed description of the invention
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the Chinese medicine composition for the treatment of infantile malnutrition
1, crude drug: Fructus Gardeniae (parched) 50kg, Natrii Sulfas 50kg, Semen Armeniacae Amarum 50kg, Pericarpium Zanthoxyli 50kg, Bulbus Allii Fistulosi 10kg.
2, preparation method:
1) the above five tastes, except Bulbus Allii Fistulosi, all the other Fructus Gardeniaes, Natrii Sulfas, Semen Armeniacae Amarum, Zanthoxyli Bungeani powder are broken into coarse powder, and particle diameter is 850 μ m;
2) add the Bulbus Allii Fistulosi of smashing to pieces, pulverize 500 μ m, then 60 DEG C of oven dry, then be ground into fine powder 350 μ m, mix, to obtain final product.
Embodiment 2: the Chinese medicine composition for the treatment of infantile malnutrition
1, crude drug: Fructus Gardeniae 200g, Natrii Sulfas 200g, Semen Armeniacae Amarum 200g, Pericarpium Zanthoxyli 200g, Bulbus Allii Fistulosi 75g.
2, preparation method:
1) the above five tastes, except Bulbus Allii Fistulosi, all the other Fructus Gardeniaes, Natrii Sulfas, Semen Armeniacae Amarum, Zanthoxyli Bungeani powder are broken into coarse powder, and particle diameter is 500 μ m.
2) add the Bulbus Allii Fistulosi of smashing to pieces, pulverize 500 μ m, then 60 DEG C of oven dry, then be ground into fine powder 350 μ m, mix, to obtain final product.
Embodiment 3: the Chinese medicine composition for the treatment of infantile malnutrition
1, crude drug: Fructus Gardeniae (stir-fry) 150kg, Natrii Sulfas 150kg, Semen Armeniacae Amarum 150kg, Pericarpium Zanthoxyli 150kg, Bulbus Allii Fistulosi 50kg.
2, preparation method:
1) the above five tastes, except Bulbus Allii Fistulosi, all the other Fructus Gardeniaes, Natrii Sulfas, Semen Armeniacae Amarum, Zanthoxyli Bungeani powder are broken into coarse powder, and particle diameter is 350 μ m.
2) add the Bulbus Allii Fistulosi of smashing to pieces, pulverize, cross 250 μ m, then 60 DEG C of oven dry, then be ground into fine powder 500 μ m, mix, to obtain final product.
Embodiment 4: patch
1, Chinese medicine composition 210g, the glycerol 80g of crude drug: embodiment 1, stearic acid 120g, triethanolamine 30g, liquid Paraffin 180g, ethyl hydroxybenzoate 1.5g.
2, preparation method:
Take each composition according to proportioning, then glycerol, stearic acid, triethanolamine, liquid Paraffin, ethyl hydroxybenzoate, distilled water are put into same container, be heated to 85 DEG C-90 DEG C and treat to dissolve completely, stop heating, be stirred to condensation, to obtain final product.
Comparative example 1: Chinese medicine composition
With reference to prior art, it consists of:
By Flos Caryophylli, Semen Armeniacae Amarum, Pericarpium Zanthoxyli, Fructus Gardeniae (parched) equal portions;
Its preparation method is with embodiment 1.
Comparative example 2: Chinese medicine composition
With reference to prior art CN95100102.7, its preparation method reference example 1, it is composed as follows:
Fructus Gardeniae 35%, Flos Caryophylli 4%, Semen Armeniacae Amarum 18%, Radix orixae japonicae 8%, Bulbus Allii Fistulosi 35%.
Experimental example 1: clinical effectiveness
Grandson, man, 18 months.Visible when first visit: emaciated physique, shallow complexion, abdominal flatulence, blue veins exposes, hypotrichosis, spirit is irritated, feverish palms, night is sleeping not peaceful, has a liking for food cold drinks and snachs, inappetence half a year, red tongue, greasy fur, deep-thready pulse.Stick the patch first quarter moon that the embodiment of the present invention 4 provides.
When further consultation, grandson has thought diet, and tympanites disappears, and thirsty alleviation, continuous with accusing more after first quarter moon.
Experimental example 2: clinical trial
1, experimental subject: 122 routine infants, wherein male 68 examples, female's 54 examples; Minimum 1 years old of age, maximum 6 years old, 2-3 year infant more.The course of disease is the shortest 1 month, the longest 6 months.Infant clinical manifestation mostly is emaciated physique, shallow complexion. the sparse tarnish of hair, and lethargy, often cries and screams, agitation, abdominal distention, inappetence, thirst and liking drink, body heat, defecates undesired, and finger sucking is ground one's teeth in sleep.
2,1,2,3 groups of Therapeutic Method: embodiment, every group of 50 examples, are prepared into according to the method for embodiment 4 medicine that patch note application embodiment 1,2,3 provided by the invention provides, and note is deposited continuously two weeks is 1 course for the treatment of, serve on 3 courses for the treatment of.1 group of Chinese medicine composition that uses comparative example 1 to provide being provided, 2 groups of Chinese medicine compositions that use comparative example 2 to provide are provided, two weeks is 1 course for the treatment of, serve on 3 courses for the treatment of.
3, curative effect determinate standard:
Cure: clinical symptom disappearance, diet is normal, in high spirits;
Take a turn for the better: clinical symptoms is improved, and appetite before takes an evident turn for the better;
Invalid: before and after treatment, symptom, sign are without improvement.
4, experimental result: in table 1
Table 1: effect comparison
| ? | Cure | Take a turn for the better | Invalid | Total effective rate |
| 1 group of embodiment | 33（66%） | 12（24%） | 5（10%） | 90% |
| 2 groups of embodiment | 34（68%） | 13（26%） | 3（6%） | 94% |
| 3 groups of embodiment | 35（70%） | 15（30%） | 0（0%） | 100% |
| Contrast 1 group | 18（36%） | 22（44%） | 10（20%） | 80% |
| Contrast 2 groups | 20（40%） | 24（48%） | 6（12%） | 88% |
Table 1 result shows:
1 group of embodiment: clinical cure 33 examples (66%), 12 examples that take a turn for the better (24%), invalid 5 examples (10%), total effective rate 90.0%;
2 groups of embodiment: clinical cure 34 examples (68%), 13 examples that take a turn for the better (26%), invalid 3 examples (6%), total effective rate 92%;
3 groups of embodiment: clinical cure 35 examples (70%), 15 examples that take a turn for the better (30%), invalid 0 example (0%), total effective rate 100%;
Contrast 1 group: clinical cure 18 examples (36%), 22 examples that take a turn for the better (44%), invalid 10 examples (20%), total effective rate 80%;
Contrast 2 groups: clinical cure 20 examples (40%), 24 examples that take a turn for the better (48%), invalid 6 examples (12%), total effective rate 88%.
Aspect effective percentage, embodiment 1-3 group all reaches more than 90%, is slightly better than contrasting 1,2 group; Aspect cure rate, embodiment 1-3 group all reaches more than 65%, apparently higher than 40% of 1,2 group of contrast.
Result of the test explanation: Chinese medicine composition provided by the invention is become thin at treatment infantile malnutrition health, irritated crowing, truly have curative effect, and successful is better than prior art when the infant of thirsty, body heat more.
Although, above use general explanation, detailed description of the invention and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (12)
1. treat the Chinese medicine composition of infantile malnutrition for one kind, it is characterized in that, described Chinese medicine composition is made up of the Chinese medicine with following weight proportion: Fructus Gardeniae (parched) 50-250 part, Natrii Sulfas 50-250 part, Semen Armeniacae Amarum 50-250 part, Pericarpium Zanthoxyli 50-250 part, Bulbus Allii Fistulosi 10-100 part, described Bulbus Allii Fistulosi is the bulb of the nearly root of liliaceous plant Herba Alii fistulosi Allium fistulosum L..
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Fructus Gardeniae (parched) 150-200 part, Natrii Sulfas 150-200 part, Semen Armeniacae Amarum 150-200 part, Pericarpium Zanthoxyli 150-200 part, Bulbus Allii Fistulosi 50-75 part.
3. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: 150 parts of Fructus Gardeniae (parched), 150 parts, Natrii Sulfas, 150 parts of Semen Armeniacae Amarums, 150 parts, Pericarpium Zanthoxyli, 50 parts of Bulbus Allii Fistulosi.
4. a method of preparing the Chinese medicine composition described in claim 1-3 any one, is characterized in that, the method comprises the following steps: take each composition according to proportioning, except Bulbus Allii Fistulosi, all the other four taste Chinese medicine powders are broken into coarse powder, add the Bulbus Allii Fistulosi of smashing to pieces, pulverize, oven drying at low temperature, to obtain final product.
5. method according to claim 4, is characterized in that, the particle size range of described coarse powder is 850 μ m-250 μ m.
6. method according to claim 5, is characterized in that, the particle size range of described coarse powder is 350-500 μ m.
7. method according to claim 4, is characterized in that, described in to add the particle size range of pulverizing after the Bulbus Allii Fistulosi of smashing to pieces be 150-500 μ m.
8. method according to claim 7, is characterized in that, described in to add the particle size range of pulverizing after the Bulbus Allii Fistulosi of smashing to pieces be 250-500 μ m.
9. method according to claim 4, is characterized in that, after oven drying at low temperature, also comprises the step of pulverizing, and its particle size range is 250-500 μ m.
10. method according to claim 9, is characterized in that, its particle size range is 350-500 μ m.
11. preparations containing the Chinese medicine composition described in claim 1-3 any one, is characterized in that, said preparation is made up separately of Chinese medicine composition or is made up of Chinese medicine composition and pharmaceutically acceptable carrier.
The application in the medicine of preparation treatment infantile malnutrition of Chinese medicine composition described in 12. claim 1-3 any one or the preparation described in claim 11.
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| CN104225548A (en) * | 2014-09-26 | 2014-12-24 | 王育明 | Formula and preparing method for infantile malnutrition external patch |
| CN104623224A (en) * | 2015-01-06 | 2015-05-20 | 曹晓凤 | Externally applied traditional Chinese medicine composition for treating infantile malnutrition and application thereof |
| CN113509493B (en) * | 2020-04-09 | 2024-01-30 | 大连麦琪克生物技术有限公司 | Antibacterial ointment for promoting wound healing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1033740A (en) * | 1988-07-30 | 1989-07-12 | 安徽省铜陵市长江路门诊部 | Chinese medicine infantile malnutrition bag and preparation method thereof |
| CN1112837A (en) * | 1995-01-06 | 1995-12-06 | 江西赣州制药厂 | Health-care adhesive plaster for removing food stagnancy for children and the prepn. method |
| CN101791381A (en) * | 2010-04-09 | 2010-08-04 | 单宏法 | Externally-applied medicine for treating infantile malnutrition of infants |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1033740A (en) * | 1988-07-30 | 1989-07-12 | 安徽省铜陵市长江路门诊部 | Chinese medicine infantile malnutrition bag and preparation method thereof |
| CN1112837A (en) * | 1995-01-06 | 1995-12-06 | 江西赣州制药厂 | Health-care adhesive plaster for removing food stagnancy for children and the prepn. method |
| CN101791381A (en) * | 2010-04-09 | 2010-08-04 | 单宏法 | Externally-applied medicine for treating infantile malnutrition of infants |
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