CN101502597B - Medicament for treating stomachache and preparation method thereof - Google Patents
Medicament for treating stomachache and preparation method thereof Download PDFInfo
- Publication number
- CN101502597B CN101502597B CN200910073914XA CN200910073914A CN101502597B CN 101502597 B CN101502597 B CN 101502597B CN 200910073914X A CN200910073914X A CN 200910073914XA CN 200910073914 A CN200910073914 A CN 200910073914A CN 101502597 B CN101502597 B CN 101502597B
- Authority
- CN
- China
- Prior art keywords
- stomach
- drug
- ache
- medicine
- stomachache
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 206010000087 Abdominal pain upper Diseases 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 210000003608 fece Anatomy 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 6
- 235000021419 vinegar Nutrition 0.000 claims description 5
- 239000000052 vinegar Substances 0.000 claims description 5
- 206010013786 Dry skin Diseases 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 235000014435 Mentha Nutrition 0.000 claims description 2
- 241001072983 Mentha Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 241000233948 Typha Species 0.000 claims description 2
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 2
- 208000007882 Gastritis Diseases 0.000 abstract description 11
- 210000002784 stomach Anatomy 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 208000023652 chronic gastritis Diseases 0.000 abstract description 6
- 208000000718 duodenal ulcer Diseases 0.000 abstract description 6
- 210000000952 spleen Anatomy 0.000 abstract description 6
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 5
- 201000005917 gastric ulcer Diseases 0.000 abstract description 5
- 230000001105 regulatory effect Effects 0.000 abstract description 5
- 230000001154 acute effect Effects 0.000 abstract description 4
- 238000005728 strengthening Methods 0.000 abstract description 4
- 210000004185 liver Anatomy 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 238000007086 side reaction Methods 0.000 abstract description 2
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 240000007126 Citrus medica var. sarcodactylis Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 244000245214 Mentha canadensis Species 0.000 abstract 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 abstract 1
- 235000004347 Perilla Nutrition 0.000 abstract 1
- 244000124853 Perilla frutescens Species 0.000 abstract 1
- 244000272264 Saussurea lappa Species 0.000 abstract 1
- 235000006784 Saussurea lappa Nutrition 0.000 abstract 1
- 241000301400 Trogopterus Species 0.000 abstract 1
- 240000001398 Typha domingensis Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000012856 packing Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000002575 gastroscopy Methods 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 239000009636 Huang Qi Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 208000008469 Peptic Ulcer Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000011906 peptic ulcer disease Diseases 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000009858 acid secretion Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a drug used for treating stomach-ache, which is prepared by adding sliced perilla stem, raidx astragali, tangerine peel, rhizoma atractylodis macrocephalae, fingered citron, cattail pollen, trogopterus dung, mentha haplocalyx, paniculate swallowwort root and costus root into water for decoction thrice, concentrating decocted fluid into extract, drying and then crushing into drug powder and packing into capsules so as to prepare capsules. The drug has the functions of regulating the flow of qi, strengthening the spleen, eliminating dampness, activating blood, dissolving stasis and relieving pain, is used for treating various stomach-ache with the total effective rate of 93.3 percent caused by stomach illnesses including gastric ulcer, duodenal ulcer, acute and chronic gastritis and the like, has high curative rate, low relapse rate, no drug resistance of anti-biotic and the like and no other side reactions of damage of western medicine preparation to the liver and kidney and the like. The invention discloses a drug used for treating stomach-ache and a preparation method thereof.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of stomachache, particularly relating to a kind of is the Chinese patent medicine of the treatment stomachache of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Stomachache is clinical common frdquently encountered disease disease, and the some diseases of modern medicine such as chronic superficial gastritis and peptic ulcer (gastric ulcer) etc. all have the stomachache symptom, has a strong impact on human healthy and mental health.At present, treatment mainly contains four big classes by the medicine of the stomachache that various stomach such as gastric ulcer, duodenal ulcer, acute or chronic gastritis cause, promptly antiacid effect, increase gastric mucosal barrier are done medication; Acid secretion blocker; Spasmolytic and medicine for stomach dynamic.Because of pathogenesis complicated different, though more than four class medicines its favourable one side is respectively arranged, be alleviating pain, all undesirable aspect elimination symptom, promotion healing, reduction recurrence, can not thoroughly cure, the relapse rate height, and the dependency of its generation and side effect are very important.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that is used for the treatment of stomachache, this Drug therapy is low by stomachache cure rate height, the relapse rate that various stomach such as gastric ulcer, peptic ulcer, duodenal ulcer, acute or chronic gastritis cause.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Caulis Perillae 10～15 Radixs Astragali 15～45
Pericarpium Citri Reticulatae 10～20 Rhizoma Atractylodis Macrocephalae (parched)s 10～30
Fructus Citri Sarcodactylis 10～15 Pollen Typhaes 10～15
Stir-baked FAECES TROGOPTERORI with vinegar 10～15 Herba Menthaes 10～20
Radix Cynanchi Paniculati 15～20 Radix Aucklandiae 3～6.
Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made medicine of the present invention may further comprise the steps:
Above-mentioned Chinese medicine is pressed described parts by weight mix homogeneously, decoct with water 3 times, each 1～2 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.0～1.2 (50 ℃), after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Stomachache claims gastric abscess again, is to be a kind of disease of cardinal symptom with gastral cavilty portion pain, and basic pathology is that taste are received the fortune abnormal ascending-descending of QI, and qi and blood stagnation is incautious, i.e. so-called " stagnation of QI and blood may bring about pain ".Its sick position is at stomach, but the closest with the relation of liver spleen.Use logical method in the treatment, make QI and blood unobstructed, the fortune of receiving is multiple normal, and " general rule is not bitterly ", stomachache is from ending.In the prescription of the present invention, Caulis Perillae is regulated the flow of vital energy, alleviating distention in middle-JIAO, pain relieving; Radix Astragali invigorating QI to consolidate the body surface resistance; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic; Fructus Citri Sarcodactylis fragrance is regulated the flow of vital energy, arresting vomiting by invigorating the stomach, reduce phlegm; Pollen Typhae, stir-baked FAECES TROGOPTERORI with vinegar vital energy regualting and blood circulation-promoting, blood-activating analgetic; The Herba Menthae dispelling wind, dispel the heat, ward off dirty, the detoxifcation; Analgesic, the promoting flow of QI and blood of Radix Cynanchi Paniculati dispelling wind; Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.All medicine compatibilities, regulating the flow of QI to ease the stomach, the spleen strengthening and damp drying, promoting blood circulation, removing blood stasis and relieving pain, it is low to be used for the treatment of stomachache cure rate height, relapse rate that various stomach such as gastric ulcer, duodenal ulcer, acute or chronic gastritis cause, and the drug resistance of antibiotic-free etc. does not have the side reactions such as infringement of other Western medicine preparations to liver, kidney yet.
For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 120 example stomachache patients that the curative effect of Drug therapy stomachache of the present invention is carried out clinical observation.
120 routine cases are divided into two groups at random, every group 60 example.Male 22 examples in the matched group, women 38 examples; 19～70 years old age, average 35.2 years old; Examine 25 examples into chronic gastritis person, stomach, duodenal ulcer person 18 examples, other 17 examples through gastroscope, barium inspection.Male 20 examples in the treatment group, women 40 examples; 16～68 years old age, average 34.6 years old; Chronic gastritis person's 28 examples, stomach, duodenal ulcer person 20 examples, other 12 examples.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse not statistically significant (P＞0.05), have comparability.All cases are all diagnosed according to the diagnostic criteria of stomachache in " new Chinese medicine clinical research guideline ".
The oral WENWEISHU CHONGJI of matched group, each 1 bag, every day 3 times.Treatment is organized oral medicament capsule of the present invention and is treated, each 2, every day 3 times, with 4 weeks be 1 course of treatment, take 2 courses of treatment altogether.
Criterion of therapeutical effect
According to " the clinical research guideline of new Chinese medicine treatment stomachache " regulation, efficacy determination with reference to change situations such as symptom, signs, is divided into healing, produce effects, effective, invalid level Four based on gastroscopy effect.Cure: symptom and sign all disappear; The complete obiteration of gastroscopy ulcer, local mild hyperaemia does not have obvious edema.Produce effects: symptom and sign are obviously improved; Gastroscopy ulcer disappears substantially, but still has inflammation.Effectively: symptom, sign have certain improvement; Gastroscopy ulcer is dwindled more than 50%.Invalid: symptom, sign all do not have improvement; Gastroscopy ulcer is dwindled not as good as 50%.
Curative effect comparative result after two groups of cases are treated sees Table 1.
Table 1 liang group case treatment back curative effect relatively
The specific embodiment
Embodiment 1
With preferred Caulis Perillae 120g, Radix Astragali 150g, Pericarpium Citri Reticulatae 120g, Rhizoma Atractylodis Macrocephalae (parched) 120g, Fructus Citri Sarcodactylis 120g, Pollen Typhae 120g, stir-baked FAECES TROGOPTERORI with vinegar 120g, Herba Menthae 100g, Radix Cynanchi Paniculati 150g, Radix Aucklandiae 40g mix homogeneously, decoct with water 3 times, each water 3.5Kg, decocted 2 hours, and merged 3 times decocting liquid, be condensed into the clear paste of 50 ℃ of relative densities 1.2, after 60 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Embodiment 2
With preferred Caulis Perillae 150g, Radix Astragali 200g, Pericarpium Citri Reticulatae 150g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Fructus Citri Sarcodactylis 150g, Pollen Typhae 150g, stir-baked FAECES TROGOPTERORI with vinegar 150g, Herba Menthae 150g, Radix Cynanchi Paniculati 180g, Radix Aucklandiae 60g mix homogeneously, decoct with water 3 times, each water 4.5Kg, decocted 1 hour, and merged 3 times decocting liquid, be condensed into the clear paste of 50 ℃ of relative densities 1.1, after 60 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Claims (1)
1. medicine that is used for the treatment of stomachache is to be crude drug by following parts by weight of traditional Chinese medicines:
Caulis Perillae 10～15 Radixs Astragali 15～45
Pericarpium Citri Reticulatae 10～20 Rhizoma Atractylodis Macrocephalae (parched)s 10～30
Fructus Citri Sarcodactylis 10～15 Pollen Typhaes 10～15
Stir-baked FAECES TROGOPTERORI with vinegar 10～15 Herba Menthaes 10～20
Radix Cynanchi Paniculati 15～20 Radix Aucklandiae 3～6
Adopt following preparation method to prepare: above-mentioned Chinese medicine is pressed described parts by weight mix homogeneously, decoct with water 3 times, each 1～2 hour, merge 3 times decocting liquid, filter, be condensed into 50 ℃ of relative densities and be 1.0～1.2 clear paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910073914XA CN101502597B (en) | 2009-03-10 | 2009-03-10 | Medicament for treating stomachache and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910073914XA CN101502597B (en) | 2009-03-10 | 2009-03-10 | Medicament for treating stomachache and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101502597A CN101502597A (en) | 2009-08-12 |
| CN101502597B true CN101502597B (en) | 2011-06-01 |
Family
ID=40975060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910073914XA Expired - Fee Related CN101502597B (en) | 2009-03-10 | 2009-03-10 | Medicament for treating stomachache and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101502597B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041335A (en) * | 2012-12-21 | 2013-04-17 | 孙红梅 | Traditional Chinese medicine composition for treating gastralgia |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728496A (en) * | 2015-11-24 | 2017-05-31 | 黄娜 | One kind stomachache decoction |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1236639A (en) * | 1999-06-22 | 1999-12-01 | 于盈光 | Chinese patent medicine for treating chronic gastritis and peptic ulcer |
-
2009
- 2009-03-10 CN CN200910073914XA patent/CN101502597B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1236639A (en) * | 1999-06-22 | 1999-12-01 | 于盈光 | Chinese patent medicine for treating chronic gastritis and peptic ulcer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041335A (en) * | 2012-12-21 | 2013-04-17 | 孙红梅 | Traditional Chinese medicine composition for treating gastralgia |
| CN103041335B (en) * | 2012-12-21 | 2015-03-18 | 张盟 | Traditional Chinese medicine composition for treating gastralgia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101502597A (en) | 2009-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103495040B (en) | Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof | |
| CN103933468A (en) | Traditional Chinese medicine for treating acute pancreatitis | |
| CN103301400A (en) | Traditional Chinese medicinal composition for treating chronic atrophic gastritis and preparation method of traditional Chinese medicinal composition | |
| CN101129636A (en) | Medicine for treating nasal inflammation | |
| CN102038829A (en) | Medicament for treating gastritis and ulcers of stomachs and duodenums | |
| CN103211990B (en) | Chinese medicinal composition for treating oral ulcer | |
| CN102091268A (en) | Medicament for treating allergic rhinitis and preparation method thereof | |
| CN101804189B (en) | Drug for treating primary dysmenorrhea | |
| CN101502597B (en) | Medicament for treating stomachache and preparation method thereof | |
| CN102908423B (en) | Traditional Chinese medicine composition for treating stones | |
| CN102552520B (en) | A kind of Huoxuezhitong capsule and its preparation process and application | |
| CN104645078A (en) | Traditional Chinese medicine composition for treating migraine | |
| CN104771509A (en) | Traditional Chinese medicine composition for treating migraine | |
| CN103845620A (en) | Traditional Chinese medicine for treating raynaud disease | |
| CN101637536B (en) | Medicine for treating chronic sinusitis and preparation method thereof | |
| CN105250858A (en) | Traditional Chinese medicine composition for treating atrophic gastritis | |
| CN110841007B (en) | Traditional Chinese medicine composition for treating cerebral apoplexy sequela and application thereof | |
| CN102205087B (en) | Chinese medicinal composition for treating chronic gastritis and preparation method thereof | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method | |
| CN1126554C (en) | Injection for mammary sland recovery | |
| CN105663850A (en) | Traditional Chinese medicine composition for treating oral ulcer | |
| CN105232609A (en) | Traditional Chinese medicine combination treating functional dyspepsia | |
| CN105267656A (en) | Traditional Chinese medicine composition for treating constipation occurring after malignant neoplasm chemotherapy | |
| CN104587397A (en) | Traditional Chinese medicinal composition for treating endocrine dyscrasia | |
| CN104758455A (en) | Traditional Chinese medicine composition for treating chronic gastritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110601 Termination date: 20120310 |