CN103961391A - Medicine composition for treating gastrointestinal psychoneurosis - Google Patents
Medicine composition for treating gastrointestinal psychoneurosis Download PDFInfo
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- CN103961391A CN103961391A CN201410154453.XA CN201410154453A CN103961391A CN 103961391 A CN103961391 A CN 103961391A CN 201410154453 A CN201410154453 A CN 201410154453A CN 103961391 A CN103961391 A CN 103961391A
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Abstract
The invention discloses a medicine composition for treating gastrointestinal psychoneurosis. The medicine composition is prepared from the following raw materials in parts by weight: 9-15 g of codonopsis pilosula, 3-12 g of fried atractylodes ovate, 3-10 g of radices saussureae and 90-110 mg of mebendazole. The dosage form of the medicine composition for treating the gastrointestinal psychoneurosis is capsule. The medicine composition for treating the gastrointestinal psychoneurosis is obtained via continuous scientific grope and researching, and specific to the pathogeny of stomach and intestine nerve function chaos and the development and recovery process of the disease. The medicine composition for treating the gastrointestinal psychoneurosis has the advantages of treating both manifestation and root cause of disease, the actovoty ratio of the medicine composition is up to over 95 percent, and the cure ratio of the medicine composition is up to over 80 percent. In addition, the medicine composition has the advantages of direct target for the pathogeny, simple formula, short cure time, low probability of recrudescence, less side effect, low cost and the like.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of gastrointestinal neurosis.
Background technology
Gastrointestinal neurosis: very common in clinical, be the gastroenteropathy that gastrointestinal nerve dysfunction causes, the one group of gastrointestinal syndrome itself occurring without organic disease.Medically be divided into stomach neurosis and intestinal neurosis (irritable bowel syndrome), be common clinically gastroenteropathy, disease shows as that gastric fullness, flatulence, belch, acid regurgitation, abdominal distention, stomachache, constipation or diarrhoea or constipation and diarrhoea replace more, feces band mucus, some patient is also often with the autonomic nervous dysfunctions' such as cardiopalmus, tachypnea, uncomfortable in chest, sweating in hand and foot, women's head-ornaments battle array heat, dizziness, headache, insomnia, menoxenia and anxiety, depression symptom.Medical science is understood so far not yet completely to primary disease pathogenesis etiology.Clinical medicine is observed and is thought: the outbreak of primary disease is relevant with the variation of emotion.Often, in anxiety, fear, depression or excitation time, make the function generation obstacle of higher nerve system cause autonomic nervous dysfunction, cause a kind of syndrome of gastrointestinal disease.Due to medically for primary disease without specific short, can only often adopt Comprehensive Treatment,, for patient's different manifestations, give symptomatic treatment.Western medical treatment as: stomachache person gives relieving spasm to stop pain medicine; Diarrhoea person gives diarrhea; Psychentonia, anxious person give tranquilizer etc.; But obstinate in most cases.The traditional Chinese medical science thinks that in dialectical gastrointestinal neurosis belongs to incoordination between the liver and stomach, incoordination between the spleen and stomach more.Therefore, take invigorating spleen and reinforcing stomach, depressed liver-energy dispersing and QI regulating and conciliate disorderly relieving restlessness as treatment rule, although there is certain effect in traditional treatment, effect is not very desirable.Owing to there is no specific short, morbidity disease is many, is clinical common difficult and complicated illness.Therefore it is very important, being badly in need of a kind of medicine good for gastrointestinal neurosis therapeutic effect, that side effect is little, cost is low of research and development.
In recent years, the related drugs about treatment gastrointestinal neurosis also has many reports.For example: 1, application number is 201010213489.2, name is called the application for a patent for invention of " a kind of prescription for the treatment of gastrointestinal neurosis ", and this patent drug compositions is mainly made by Radix Bupleuri, Fructus Gardeniae, Cortex Moutan, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Fructus Aurantii Immaturus, Herba Dendrobii, Spica Prunellae, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride and Rhizoma Coptidis.2, application number is 200410064767.7, name is called the application for a patent for invention of " a kind of prescription for the treatment of gastrointestinal neurosis, gastritis ", this application drug main will be comprised of Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens and Herba Menthae, adds in addition oryzanol, vitamin B1 and diazepam.3, application number is 200910229327.5, name is called the patent of invention of " Chinese medicine formula for the treatment of gastrointestinal neurosis ", and the medicine of this Patent Application Publication is comprised of Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Semen Coicis, Pericarpium Citri Reticulatae, Seem Lablab Album, Rhizoma Dioscoreae, Rhizoma Zingiberis and Radix Glycyrrhizae.
Summary of the invention
The technical problem to be solved in the present invention is: a kind of pharmaceutical composition for the treatment of gastrointestinal neurosis is provided.Utilize Drug therapy gastrointestinal neurosis of the present invention, its therapeutic effect is good, side effect is less, and cost is low.
In order to address the above problem, the technical solution used in the present invention is:
The invention provides a kind of pharmaceutical composition for the treatment of gastrointestinal neurosis, with weight portion, represent, described pharmaceutical composition is by Radix Codonopsis 9～15g, Rhizoma Atractylodis Macrocephalae (parched) 3～12g, and the Radix Aucklandiae 3～10g and mebendazole 90～110mg form.
Pharmaceutical composition according to above-mentioned treatment gastrointestinal neurosis, represents with weight portion, and described pharmaceutical composition is by Radix Codonopsis 9～15g, Rhizoma Atractylodis Macrocephalae (parched) 3～12g, and the Radix Aucklandiae 3～10g and mebendazole 100mg form.
Pharmaceutical composition according to above-mentioned treatment gastrointestinal neurosis, represents with weight portion, and described pharmaceutical composition is by Radix Codonopsis 10～13g, Rhizoma Atractylodis Macrocephalae (parched) 5～10g, and the Radix Aucklandiae 5～8g and mebendazole 100mg form.
According to the pharmaceutical composition of above-mentioned treatment gastrointestinal neurosis, the dosage form of the pharmaceutical composition of described treatment gastrointestinal neurosis is capsule.
According to the pharmaceutical composition of above-mentioned treatment gastrointestinal neurosis, the preparation method for the treatment of gastrointestinal neurosis capsule is: first according to the composition and ratio of the treatment gastrointestinal neurosis pharmaceutical composition described in above-mentioned any one, prepare various raw materials, the Radix Codonopsis taking, Rhizoma Atractylodis Macrocephalae (parched) and the Radix Aucklandiae are pulverized respectively, after pulverizing, mix, gained mixed powder is carried out to water extraction 2～3 times, in leaching process, the addition of water is 8～10 times of three kinds of medicine total amounts; The aqueous extract that merges 2～3 gained; Then according to conventional method, gained extracting solution is concentrated, being concentrated into relative density is 1.0～1.3; Gained concentrate is dried, after oven dry, pulverize, gained is pulverized rear medicated powder and mebendazole mix homogeneously, incapsulates, and gastrointestinal neurosis capsule obtains medical treatment.
According to the pharmaceutical composition of above-mentioned treatment gastrointestinal neurosis, described capsule adopts No. 2 capsules, packs medicated powder 0.25g in every capsules into.
The present invention treats the instructions of taking of gastrointestinal neurosis capsule: every day 2 times, sooner or later service once, before or after meals take all can, 12 years old above and adult, each 3～4, within 6～12 years old, child is each 2～3.A course for the treatment of two Mondays.
the pharmacological action of the various crude drug of the present invention is as follows:
Radix Codonopsis: property is flat, sweet in the mouth, the effect with invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, can also strengthen body immunity, improve the activity of superoxide dismutase, strengthen the ability of eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.The disease such as be applicable to deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency cough, interior-heat are quenched one's thirst.
Effective ingredient contained in Radix Codonopsis has excitation to nervous system, and energy enhancing body resistance, can increase erythrocyte and hemoglobin again; Wherein contained zinc can enhancing development and is improved sexual function, containing polysaccharide, phenols, sterol, volatile oil, vitamin B1, B2, and necessary aminoacid, scutellarein glucosid, Saponin and the Alkaloid of multiple human body, trace element etc.Nervous system is had to excitation, energy enhancing body resistance; There is Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduces the effects such as pepsin activity; Can make a rabbit erythrocyte, hemoglobin increase, chemotherapy, the caused leukopenia of radiotherapy are had to castering action; Can expand peripheral vessels and reduce blood pressure, can suppress adrenergic boosting again.
Rhizoma Atractylodis Macrocephalae (parched): this product has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive.Be usually used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, the cards such as frequent fetal movement.Medical evidence has the gastrointestinal motility of adjustment function: Rhizoma Atractylodis Macrocephalae decocting liquid is relevant on the impact of rabbit motility of isolated ileocecal segment and intestinal tube functional status of living in.There is under normal circumstances excitation, when intestinal tube is subject to acetylcholine effect and during in excitatory state, the Rhizoma Atractylodis Macrocephalae is inhibitory action; When intestinal tube is subject to epinephrine effect and during in inhibitory state, the Rhizoma Atractylodis Macrocephalae is again excitation, all can make intestinal tube activity return to and approach normal level.Antiulcer: the acetone extract gastric infusion of the Rhizoma Atractylodis Macrocephalae, has obvious inhibitory action to gastric mucosa damage due to hydrochloric acid-ethanol.Through duodenal administration, pylorus ligation rat gastric secretion is had to inhibitory action, reduce gastric acidity, reduce gastric acid and pepsic output.Enhancing human body immunity function: the Rhizoma Atractylodis Macrocephalae can significantly strengthen the ability of leukocytes phagocytic staphylococcus aureus.
The Radix Aucklandiae: this product acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel, fragrance row is loose, can rise and can fall.This product mainly has following effect:
1, promoting the circulation of QI to relieve pain: vomit for abdominal distention, lack of appetite due to stagnation of QI in spleen and stomach;
2, regulate the flow of vital energy soothing the liver: the hypochondriac pain causing for QI stagnation of the liver and galibladder;
3, spleen invigorating disappears stagnant: the stagnant gas of adjustable gastrointestinal.Treatment stomachache, diarrhoea, tenesmus.
The pungent temperature of this product is fragrant loose, can rise and can fall, and leads to the gas of managing three warmers, and the especially gas of benefaction gastrointestinal and pain relieving has the merit of strengthening the spleen to promote digestion concurrently, and all cards are conventional product due to all taste QI stagnation of the large intestine.
Antibacterial action: volatile oil 1:3000 concentration can suppress the growth of streptococcus, golden yellow and white grapes, faint to escherichia coli and diphtheria corynebacterium effect; Total alkaloids is without antibacterial action.This savors decoct except paratyphoid fever bacillus is had slight inhibitory action, invalid to 7 kinds of pathogenic bacterium such as staphylococcus aureus, dysentery bacteriums.Separately have report, decoct has inhibitory action to 10 kinds of funguses such as oidium schoenleinii and Mongolian mutation thereof.
Mebendazole: mebendazole is a wide spectrum anthelmintic, in body or in vitro tests all prove and can directly suppress the absorption of nematicide to glucose, cause glycogen depletion, it cannot be survived, there is the effect of killing significantly larva, suppressing ovulation development, but do not affect blood in human body in sugar level.Can be used for preventing and treating the intestinal parasitical diseases such as ancylostome, ascarid, pinworm, whipworm, excrement class loop line worm.
Mebendazole, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), the Radix Aucklandiae in prescription of the present invention, have the effect of removing the cause of disease, recovery gastrointestinal function of nervous system, invigorating the spleen and benefiting QI, promoting the circulation of QI to relieve pain, stomach function regulating relieving distension, promoting gastrointestinal function rehabilitation.The effect that wherein mebendazole has anthelmintic, recovers gastrointestinal physiological function.Under physiological conditions: human body is a Unified Global, each organ dysfunction is all under cerebral neural unified coordination, and coordination mutually, mutual restriction reach the body health that a kind of balance could be safeguarded people.Gastrointestinal physiological function is also the vegetative nerve function of gastrointestinal.Vegetative nerve be not subject to the consciousness meaning just control can automatic regulator official function nerve.That is to say that it is not subject to the control of ideology, the digestive and absorptive functions of its gastrointestinal just can oneself complete.Once certain cause of disease causes gastrointestinal dysfunction, dispels the cause of disease, gastrointestinal dysfunction can recover normally, and disease just can rehabilitation.Clinical medicine proof Enterozoa can cause gastrointestinal autonomic nervous dysfunction.Mebendazole can effectively be killed larva, suppress the effect of ovulation development, directly suppresses the absorption of nematicide to glucose, causes glycogen depletion, and it cannot be survived.Prescription of the present invention, by clinical practice for many years, adopts mebendazole anthelmintic, dispels the cause of disease that causes gastrointestinal dysfunction, recovers gastrointestinal physiological function, by clinical practice for many years, observes very effective to the treatment of gastrointestinal neurosis.The traditional Chinese medical science is thought: the gastric fullness that gastrointestinal neurosis causes, flatulence, belch, acid regurgitation, abdominal distention, stomachache, constipation diarrhoea or constipation and diarrhoea replaces, feces band mucus is that gastrointestinal nerve dysfunction causes incoordination between the spleen and stomach, obstinate disease, due to weakness of the spleen and stomach; And Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), the Radix Aucklandiae have invigorating the spleen and benefiting QI, promoting the circulation of QI to relieve pain, the effects such as stomach function regulating relieving distension.Radix Codonopsis has the effect of invigorating the spleen and benefiting QI, and the disease that can improve gastro-intestinal digestion absorption function, adjustable gastric enteric nervous function, disorderly nerve is caused is recovered.It is Main Function that Rhizoma Atractylodis Macrocephalae (parched) be take spleen invigorating, dampness, antidiarrheal, by forefathers' reputation be " air making-up and spleen enlivening the first key medicine ", be usually used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels; The Radix Aucklandiae has the effect of promoting the circulation of QI to relieve pain, stomach function regulating relieving distension, antidiarrheal, share with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), both can strengthen replenishing QI to invigorate the spleen effect, again can be to the disease good results such as the stomachache due to incoordination between the spleen and stomach, diarrhoea, pipe abdomen fullness, medical evidence: the Radix Aucklandiae also has good result to gastrointestinal infection.Full side has the effect that recovers gastrointestinal physiological function and promote rehabilitation in a word, can take stopgap measures and can effect a permanent cure, and has the dual function for the treatment of both the principal and secondary aspects of a disease.
positive beneficial effect of the present invention:
1, the present invention treats the medicine of gastrointestinal neurosis, is for the pathogenesis etiology and advancing of disease and the recovery process that cause gastrointestinal nerve dysfunction, from the angle of science by constantly groping to find out.The present invention treats gastrointestinal neurosis medicine and has advantages for the treatment of both the principal and secondary aspects of a disease, and its effective percentage reaches more than 95%, and cure rate reaches more than 80%.Therefore, medicine of the present invention has directly for the cause of disease, formula is simple, treatment time is short, be difficult for recurrence, side effect is little, low cost and other advantages.
2, utilize the present invention to treat the medicine of gastrointestinal neurosis and the clinical material of capsule for treating gastrointestinal disease thereof:
Over more than 20 year, utilize the present invention to treat patient's 181 examples of gastrointestinal neurosis Chinese and western medicinal composition and capsule for treating gastrointestinal function of nervous system thereof, male 111 examples, female's 70 examples, minimum 12 years old of age, maximum 81 years old.78 examples of a course for the treatment of of capsule of taking that the present invention treats gastrointestinal neurosis Chinese and western medicinal composition, 103 examples of two courses for the treatment of of capsule of taking that the present invention treats gastrointestinal neurosis Chinese and western medicinal composition.Wherein cure 151 examples, effective 21 examples, no effect 9.Cure rate reaches more than 80%, and total effective rate reaches 95%.Therefore, adopt Chinese and western medicinal composition of the present invention and capsule for treating gastrointestinal neurosis thereof, its therapeutic effect is remarkable.
The present invention treats the instructions of taking of gastrointestinal neurosis capsule: one day 2 times, sooner or later each once, before or after meals take all can, two weeks 1 courses for the treatment of; 12 years old above and adults, each 3～4, within 6～12 years old, child is each 2～3.
model case:
Song, man, 65 years old, Zhumadian prefecture, Henan province city people from Xincai County, without diet bad habit, often gastric fullness flatulence, insomnia, brains dusk is swollen, and gastric fullness abdominal distention alleviates, and easily diarrhoea, defecate three to four times on the one, a little i.e. recurrence that is not careful in one's diet, extremity sleepiness.Wuhan PLA General Hospital is diagnosed as gastrointestinal neurosis through expert, three months poor effect of Gai hospital medication treatment.Carry out after being introduced here treatment, taking medicine of the present invention treats gastrointestinal neurosis capsule second day and has positive effect, insomnia disappearance, brains swollen disappearance of dusk, abdominal distention gastric fullness alleviate, weak alleviating, continue again to take the present invention and treat gastrointestinal neurosis capsule (pharmaceutical formulation that this capsule adopts is identical with embodiment 1 pharmaceutical formulation), treat two months, disease disappears, and stops treatment, follows up a case by regular visits to not recurrence in 4 years.
Grandson, man, 62 years old, Zhumadian prefecture, Henan province city people from Shangcai County, without diet bad habit, frequent gastric fullness abdominal distention, stomachache insomnia, inappetence, defecates shapeless but without mucus.Therefore, the medicine of some treatment gastrointestinal diseasies for informal dress is heavy when light during the state of an illness.In BJ Union Hospital, be diagnosed as gastrointestinal neurosis many years ago.According to doctor's advice medication treatment two months, take a turn for the better to some extent, treatment is not healed later repeatedly.Here treatment in the situation that treatment is hopeless, take medicine of the present invention and treat gastrointestinal neurosis capsule after three days, just sensation insomnia, gastric fullness abdominal distention, the shapeless all improvements to some extent of defecating, continue again to take the present invention and treat gastrointestinal neurosis capsule for treating after four courses for the treatment of (pharmaceutical formulation that this capsule adopts is identical with embodiment 6 pharmaceutical formulations), above-mentioned disease disappears, and follows up a case by regular visits to without recurrence after 6 years.
Zhao, man, 23 years old, Zhumadian prefecture, Henan province city people from Pingyu County, beginning in seven or eight years old is bad with regard to gastrointestinal, without diet bad habit, frequent gastric fullness abdominal distention, belch acid regurgitation, insomnia sleepiness, confused swollen, the tinnitus of brains, constipation abdomen is write alternately, and stool is with mucus, lassitude loin and legs, night sweat, seminal emission, sallow complexion, shortness of breath and palpitation, spirit is indigestion and loss of appetite, at local county hospital, is diagnosed as chronic colitis.According to doctor's advice medication treatment poor effect, took Spleen Invigorating and Intestine Tonifying Pill and maintained treatment at that time.Afterwards, in the Zhumadian prefecture, Henan province First Five-Year Plans nine, military hospital was diagnosed as stomach neurosis, irritable bowel syndrome.In hospitalize two weeks poor effect, oneself require to leave hospital.Take at ordinary times a little tranquilizers, enteritis, gastropathy medicine symptomatic treatment.After here is medical, the same day, gastrointestinal disease symptom alleviated, and insomnia is eliminated, and had a rest good, and second day is just felt to take a favorable turn.Take continuously the present invention and treat gastrointestinal neurosis capsule after two courses for the treatment of (pharmaceutical formulation that this capsule adopts is identical with embodiment 8 pharmaceutical formulations), sensory recovery is normal, and the medicine of often taking in the past has also stopped, and has rosy cheeks, so far not recurrence.
Liu, female, 42 years old, sensation was fallen ill for two more than ten years certainly, and without diet bad habit, often insomnia, gastric fullness abdominal distention, constipation diarrhoea are alternately, extremity are aching and limp, brains is confused swollen; In Zhumadian City central hospital, be diagnosed as gastrointestinal neurosis, hospitalization fortnight takes a turn for the better to some extent, leaves hospital by a little tranquilizers of informal dress, gastrointestinal disease medicine.Carry out after being introduced here treatment, take that the present invention treats gastrointestinal neurosis capsule second day insomnia, gastric fullness abdominal distention take a favorable turn, continue to take the present invention and treat gastrointestinal neurosis capsule after three courses for the treatment of (pharmaceutical formulation that this capsule adopts is identical with embodiment 11 pharmaceutical formulations), above-mentioned symptom disappears, so far within 8 years, feel good, do not recur again.
Chen, man, 29 years old, Zhumadian prefecture, Henan province city people from Pingyu County, without diet bad habit, disease time 2 years, insomnia, brains dusk is swollen, stomach still can, stool band mucus, defecates shapeless, the soft sleepiness of lower limb.In the People's Hospital, Zhumadian City, be diagnosed as chronic colitis, two months poor effect of hospitalize, oneself take Spleen Invigorating and Intestine Tonifying Pill more than a year, defecate one day two to three times, occasionally have stomachache, repeatedly do not heal.After in here treatment, take the present invention treat gastrointestinal neurosis capsule second day just insomnia disappear, clearheaded, without bowel movement, within the 3rd day, stool is normal, mucus reduces.Take the present invention and treat (pharmaceutical formulation that this capsule adopts is identical with embodiment 14 pharmaceutical formulations) after gastrointestinal neurosis capsule two weeks, conscious, disease disappears, and withdrawal is followed up a case by regular visits to 12 years so far without recurrence.
Guo, female, 52 years old, Zhumadian prefecture, Henan province city people from Pingyu County, bad with regard to body constitution at an early age, without diet bad habit, inappetence; Often gastric fullness, abdominal distention, insomnia, brains dusk is swollen, limbs fatigue, constipation often, and diarrhoea often, stool is sometimes with mucus.Through local hospital treatment, repeatedly do not heal.Hou Henan Prov. People's Hospital is diagnosed as gastrointestinal neurosis, merges chronic cholecystitis, and after treatment, effect is undesirable.The rehabilitation of disease has also been lost to confidence, often taken medicines of some treatment cholecystitis and the medicine for the treatment of gastrointestinal disease carrys out mitigate the disease, be afraid of that abdominal distention dare not have supper evening.Come after being introduced here medical, take the present invention and treat after gastrointestinal neurosis capsule, that night, pipe abdomen fullness alleviated, and insomnia is alleviated.The rear the present invention that continues to take medicine treats gastrointestinal neurosis capsule after two courses for the treatment of (pharmaceutical formulation that this capsule adopts is identical with embodiment 1 pharmaceutical formulation), appetite might as well, cholecystitis symptom has also been eliminated, defecate also normal, through the thorough rehabilitation of examination in hospital, the medicine of often eating at ordinary times has also stopped, not recurrence so far in 15 years.
the specific embodiment:
Below in conjunction with embodiment, further set forth the present invention, but do not limit content of the present invention.
Embodiment 1:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 12g, Rhizoma Atractylodis Macrocephalae (parched) 8g, and Radix Aucklandiae 6g and mebendazole 100mg form.
Embodiment 2:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae (parched) 5g, and Radix Aucklandiae 4g and mebendazole 95mg form.
Embodiment 3:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 14g, Rhizoma Atractylodis Macrocephalae (parched) 10g, and Radix Aucklandiae 8g and mebendazole 105mg form.
Embodiment 4:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 12g, and Radix Aucklandiae 10g and mebendazole 110mg form.
Embodiment 5:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 9g, Rhizoma Atractylodis Macrocephalae (parched) 3g, and Radix Aucklandiae 3g and mebendazole 90mg form.
Embodiment 6:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae (parched) 10g, and Radix Aucklandiae 8g and mebendazole 102mg form.
Embodiment 7:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 13g, Rhizoma Atractylodis Macrocephalae (parched) 6g, and Radix Aucklandiae 8g and mebendazole 92mg form.
Embodiment 8:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 12g, Rhizoma Atractylodis Macrocephalae (parched) 7g, and Radix Aucklandiae 8g and mebendazole 98mg form.
Embodiment 9:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae (parched) 5g, and Radix Aucklandiae 5g and mebendazole 100mg form.
Embodiment 10:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 13g, Rhizoma Atractylodis Macrocephalae (parched) 10g, and Radix Aucklandiae 8g and mebendazole 100mg form.
Embodiment 11:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 12g, Rhizoma Atractylodis Macrocephalae (parched) 7g, and Radix Aucklandiae 6g and mebendazole 100mg form.
Embodiment 12:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 11g, Rhizoma Atractylodis Macrocephalae (parched) 9g, and Radix Aucklandiae 7g and mebendazole 100mg form.
Embodiment 13:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae (parched) 5g, and Radix Aucklandiae 4g and mebendazole 100mg form.
Embodiment 14:
The present invention treats the pharmaceutical composition of gastrointestinal neurosis, with weight portion, represents, described pharmaceutical composition is by Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae (parched) 9g, and Radix Aucklandiae 8g and mebendazole 100mg form.
The preparation method of the embodiment of the present invention 1～14 treatment gastrointestinal neurosis capsule is:
First according to the composition and ratio of the treatment gastrointestinal neurosis pharmaceutical composition described in the arbitrary embodiment of embodiment 1～14, prepare various raw materials, the Radix Codonopsis taking, Rhizoma Atractylodis Macrocephalae (parched) and the Radix Aucklandiae are pulverized respectively, after pulverizing, mix, mixed raw material is put into pot and add water soaking 20 minutes, the addition of water is 10 times of raw material gross weight, soaks post-heating steaming and decocting, boils 25～30 minutes after boiled, after boiling, filter, obtain aqueous extract for the first time; According to this water extraction method, carry out again water extraction 2 times, obtain respectively for the second time and aqueous extract for the third time; The aqueous extract that merges 3 gained; Then according to conventional method, gained extracting solution is concentrated, being concentrated into relative density is 1.2; Gained concentrate is dried, after oven dry, pulverize, gained is pulverized rear medicated powder and mebendazole mix homogeneously, packs capsule into No. 2, packs medicated powder 0.25g in every capsules into, and gastrointestinal neurosis capsule obtains medical treatment.
Claims (6)
1. a pharmaceutical composition for the treatment of gastrointestinal neurosis, is characterized in that: with weight portion, represent, described pharmaceutical composition is by Radix Codonopsis 9～15g, Rhizoma Atractylodis Macrocephalae (parched) 3～12g, and the Radix Aucklandiae 3～10g and mebendazole 90～110mg form.
2. the pharmaceutical composition for the treatment of gastrointestinal neurosis according to claim 1, is characterized in that: with weight portion, represent, described pharmaceutical composition is by Radix Codonopsis 9～15g, Rhizoma Atractylodis Macrocephalae (parched) 3～12g, and the Radix Aucklandiae 3～10g and mebendazole 100mg form.
3. the pharmaceutical composition for the treatment of gastrointestinal neurosis according to claim 1, is characterized in that: with weight portion, represent, described pharmaceutical composition is by Radix Codonopsis 10～13g, Rhizoma Atractylodis Macrocephalae (parched) 5～10g, and the Radix Aucklandiae 5～8g and mebendazole 100mg form.
4. the pharmaceutical composition for the treatment of gastrointestinal neurosis according to claim 1, is characterized in that: the dosage form of the pharmaceutical composition of described treatment gastrointestinal neurosis is capsule.
5. the pharmaceutical composition for the treatment of gastrointestinal neurosis according to claim 4, it is characterized in that, the preparation method for the treatment of gastrointestinal neurosis capsule is: first according to the composition and ratio of the treatment gastrointestinal neurosis pharmaceutical composition described in claim 1～3 any one, prepare various raw materials, the Radix Codonopsis taking, Rhizoma Atractylodis Macrocephalae (parched) and the Radix Aucklandiae are pulverized respectively, after pulverizing, mix, gained mixed powder is carried out to water extraction 2～3 times, in leaching process, the addition of water is 8～10 times of three kinds of medicine total amounts; The aqueous extract that merges 2～3 gained; Then according to conventional method, gained extracting solution is concentrated, being concentrated into relative density is 1.0～1.3; Gained concentrate is dried, after oven dry, pulverize, gained is pulverized rear medicated powder and mebendazole mix homogeneously, incapsulates, and gastrointestinal neurosis capsule obtains medical treatment.
6. the pharmaceutical composition for the treatment of gastrointestinal neurosis according to claim 5, is characterized in that: described capsule adopts No. 2 capsules, packs medicated powder 0.25g in every capsules into.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410154453.XA CN103961391B (en) | 2014-04-17 | 2014-04-17 | A kind of pharmaceutical composition treating gastrointestinal neurosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410154453.XA CN103961391B (en) | 2014-04-17 | 2014-04-17 | A kind of pharmaceutical composition treating gastrointestinal neurosis |
Publications (2)
| Publication Number | Publication Date |
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| CN103961391A true CN103961391A (en) | 2014-08-06 |
| CN103961391B CN103961391B (en) | 2016-08-31 |
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| CN201410154453.XA Expired - Fee Related CN103961391B (en) | 2014-04-17 | 2014-04-17 | A kind of pharmaceutical composition treating gastrointestinal neurosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105796654A (en) * | 2016-04-05 | 2016-07-27 | 中国人民武装警察部队后勤学院 | Traditional Chinese medicine composition for treating diarrhea irritable bowel syndrome, navel paste and application |
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| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| CN102670702A (en) * | 2012-06-04 | 2012-09-19 | 黄芸 | Costus root Chinese medicine oral liquid for treating chronic gastroenteritis and preparation method of same |
| WO2013177067A2 (en) * | 2012-05-19 | 2013-11-28 | Zhao Aiping | Herbal composition for treatment of gastrointestinal inflammatory diseases and method to prepare and use thereof |
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| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| WO2013177067A2 (en) * | 2012-05-19 | 2013-11-28 | Zhao Aiping | Herbal composition for treatment of gastrointestinal inflammatory diseases and method to prepare and use thereof |
| WO2013177067A3 (en) * | 2012-05-19 | 2014-01-16 | Zhao Aiping | Herbal composition for treatment of gastrointestinal inflammatory diseases and method to prepare and use thereof |
| CN102670702A (en) * | 2012-06-04 | 2012-09-19 | 黄芸 | Costus root Chinese medicine oral liquid for treating chronic gastroenteritis and preparation method of same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796654A (en) * | 2016-04-05 | 2016-07-27 | 中国人民武装警察部队后勤学院 | Traditional Chinese medicine composition for treating diarrhea irritable bowel syndrome, navel paste and application |
| CN105796654B (en) * | 2016-04-05 | 2020-07-03 | 中国人民武装警察部队后勤学院 | Traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome, navel patch and application |
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| CN103961391B (en) | 2016-08-31 |
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