CN104116912A - Traditional Chinese medicinal composition for rehabilitation after radiotherapy and chemotherapy of tumor patients - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal composition for rehabilitation after radiotherapy and chemotherapy of tumor patients. The composition comprises the following raw medicinal materials: astragalus membranaceus, Chinese angelica, codonopsis pilosula, donkey-hide gelatin, prepared rehmannia root, rhizoma polygonati, adenophora tetraphylla, radix glehniae, fructus corni, suberect spatholobus stem, radix ophiopogonis, common yam rhizome, rhizoma atractylodis macrocephalae, roasted liquorice and the like, has the effects of tonifying qi and tranquilizing, nourishing spleen and kidney, can be used for tonifying both qi and blood and treating both symptoms and root causes, has a remarkable drug effect, and can balance the human body immunity. The traditional Chinese medicinal composition has an excellent using effect, can be used for effectively relieving gastrointestinal discomfort and other syndromes caused by radiotherapy and chemotherapy. The medicinal materials of the composition are compatible to play the functions of strengthening spleen and harmonizing stomach, tonifying qi and nourishing blood, can be used for effectively treating gastrointestinal discomfort, qi-blood deficiency, hypoimmunity and other syndromes after a tumor patient is subjected to radiotherapy and chemotherapy.

Description

A kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of rehabilitation after tumor patient chemicotherapy, belong to the field of Chinese medicines.

Background technology

Tumor is one of major disease of current serious threat people life security, no matter both at home and abroad, has a large amount of patients dead because suffering from tumor every year.Tumor has become the first healthy killer of harm humans, and becomes one of maximum public health problem in the whole world.According to WHO report, between 10 years of the past, the morbidity of global tumor and death have increased approximately 22%.In average every 8 deaths in the whole world, just have 1 people to die from tumor, the death toll summation causing than acquired immune deficiency syndrome (AIDS), tuberculosis and malaria is taller.The research report demonstration of IARC, will be than present increase by 50% to the year two thousand twenty whole world tumor incidence, and the annual newly-increased tumor patient number in the whole world will reach 1,500 ten thousand.2008, the data show that WHO issues, China has become second-biggest-in-the-world tumor state occurred frequently, and the statistics of China's Ministry of Public Health shows, and annual China newborn tumor patient sum approximately 212.7 ten thousand people wherein, have the newborn patient of malignant tumor of 1,060,000 left and right every year; Meanwhile, approximately there is the existing patient of tumor of 268.5 ten thousand left and right in the whole nation, wherein, the existing patient of malignant tumor approximately 148.5 ten thousand left and right, tumor becomes the second largest disease of China after cardiovascular and cerebrovascular disease.

There are two kinds of patterns, i.e. western medical treatment and Chinese traditional treatment at the current oncotherapy of China.Western medical treatment mainly comprises operative treatment, radiotherapy and chemotherapy at present.The toxicity of chemicotherapy refers in the therapeutic process of tumor, because lonizing radiation and chemicals lack selectivity between normal cell and cancerous cell, in the time that cancer patient applies chemicotherapy, in suppressing tumor, often the cell of body molecular marker for increased proliferation is had a certain impact and damaged, produce clinically a lot of side reactions, the lighter can recover voluntarily, severe one impact effect, even therefore therapy discontinued, causes tumor to spread rapidly.Radiotherapy toxic side effect symptom has weak, feels sick, and poor appetite, vomiting, diarrhoea, leukopenia, tissue edema, necrosis and fibrosis, skin erythema, dry reaction, wet reaction, ulcer, radiation rectitis, pneumonia and cranial nerve palsy, paraplegia etc.The toxicity that chemotherapeutics produces is divided into two classes: in the recent period toxicity has local response and general reaction, the former visible pain, and swelling, tissue necrosis, vein hardening, is streak change, even permanent occlusion; The visible leukopenia of the latter, thrombocytopenia, when serious, hemoglobin reduces, nausea and vomiting, oral ulcer,, when serious, there is bloody diarrhea, liver function injury and cardiopulmonary toxicity, nervous system damage etc. in diarrhoea.Toxicity at a specified future date common are growth retardation, sterile, immunosuppressant etc.

The traditional Chinese medical science thinks that tumor is a systemic disease, weakened body resistance blood stasis, and residual poison is not clearly its pathogenic characteristic, " void, poison, the stasis of blood, knot " runs through it and develops overall process.The transfer of tumor is the imbody of its generalization, and the basic reason of neoplasm metastasis is healthy energy virtual loss, in evil poison, accumulates.No matter perform the operation or chemicotherapy treatment, though reached and effectively subtracted the tumor object that uncharms, but fail fundamentally to remove the imbalance of patient's internal organs, negative and positive, QI and blood function, therefore the theory considering determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to the Overall View of Chinese medicine, include radiotherapy, chemotherapy in diagnosis and prescription category, form doctor trained in Western medicine and attack heresy, the general layout of traditional Chinese medical science righting, the method of the employing combination of Chinese and Western medicine is carried out oncotherapy and often can be obtained good effect, and Chinese medicine more and more gets the nod to the auxiliary therapeutic action of tumor patient.

Summary of the invention

The object of the invention is to provide a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, and the disease that can be used for causing after tumor patient chemicotherapy is seen gastrointestinal upset, inappetence, spiritlessness and weakness, deficiency of QI with disinclination to talk, hypoimmunity etc.

For this reason, the technical solution adopted in the present invention is, a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, by weight, comprise following component raw material: Radix Astragali 20-30 part, Radix Angelicae Sinensis 10-20 part, Radix Codonopsis 20-30 part, Colla Corii Asini 20-30 part, Radix Rehmanniae Preparata 10-15 part, Rhizoma Polygonati 10-15 part, Radix Adenophorae 10-15 part, Radix Glehniae 10-15 part, Fructus Corni 10-15 part, Caulis Spatholobi 10-15 part, Radix Ophiopogonis 10-20 part, Rhizoma dioscoreae 10-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Glycyrrhizae Preparata 5-8 part.

Be decocted in water for oral dose, potion on the one, takes at twice.

The present invention has invigorating QI and tranquilization, supports the effect of spleen and tonifying kidney, qi and blood tonifying, and treating both the principal and secondary aspects of a disease, drug effect is remarkable, can balance body immunity.Drug use of the present invention is respond well, can effectively alleviate the symptoms such as the gastrointestinal upset being caused by chemotherapy, radiotherapy.The all medicines of the present invention share, and play altogether invigorating the spleen and regulating the stomach, the merit of benefiting qi and nourishing blood, the gastrointestinal upset due to can effectively treating after tumor patient chemicotherapy, insufficiency of vital energy and blood, the diseases such as hypoimmunity.In the present invention, the pharmacological action of each crude drug is as follows:

The Radix Astragali: the Radix Astragali is sweet, tepor, returns spleen lung two warps, effect spleen invigorating invigorating middle warmer, ascending up spleen-Qi and Yang, benefit is defended consolidating superficial resistance, diuresis, promoting pus discharge and tissue regeneration strengthening.Modern pharmacological research shows: the Radix Astragali is containing glycoside, polysaccharide, aminoacid etc., astragalus polysaccharides is by regulating immune system to bring into play antitumor action, as strengthen the activity of peritoneal macrophage, bone-marrow-derived lymphocyte and NK cell, promote the generation of the immune factors such as IL-2, TNF and INF, promote the lymphocytic enhancing of T to transform.

Radix Angelicae Sinensis: property is sweet, pungent, warm, returns liver, the heart, spleen channel, and main effect is tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.The sweet temperature of Radix Angelicae Sinensis, matter profit, be longer than and enrich blood, and is the panacea of enriching blood.Coordinate Radix Astragali Qi-tonifying drug, the effect of playing altogether benefiting vital QI and blood, it is so-called that " tangible blood can not be spontaneous, is born in invisible gas." the pungent temperature of Radix Angelicae Sinensis is passed through, and is the key medicine of blood-activating and qi-promoting, also has certain curative effect for the constipation of blood deficiency dryness of the intestine.Modern pharmacological research discovery, Radix Angelicae Sinensis has multiple pharmacological effect: can suppress smooth muscle, anticoagulation and promotion blood coagulation, enrich blood, antioxidation and defying age, antiinflammatory and enhancing are immune, protection ischemic injuries, promotion cell proliferation, the effects such as antitumor.

Radix Codonopsis: there is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition leukopenia chemotherapy radiotherapy being caused has castering action.

Colla Corii Asini: property is sweet, equal, return lung, liver, kidney channel, effect for enriching blood, YIN nourishing, lung moistening, hemostasis.Colla Corii Asini is the in love product of flesh and blood, and Gan Ping, matter profit, is the key medicine of enriching blood, and is used for all diseases of blood deficiency, has again anastalsis simultaneously, so for hemorrhage and the empty effect of hyperamization is better.Modern pharmacological research, Colla Corii Asini has obvious blood tonification effect, promotes hemopoietic function, improves hemopoietic function, improves immunity of organisms, improves anoxia enduring, fatigue resistance.

Radix Rehmanniae Preparata: sweet in the mouth, warm in nature, return liver; Kidney channel.Enrich blood moist; Benefit essence is filled out marrow, is tonic, cures mainly blood deficiency and yellow complexion; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.

Rhizoma Polygonati: sweet in the mouth, property is flat.Energy nourishing kidney lung moistening, invigorating the spleen and replenishing QI.Containing aspartic acid, digitalis glucoside, anthraquinone analog compound, phlegmatic temperament, saccharide, nicotinic acid, zinc, copper, ferrum.There are anti-hypoxia, resisting fatigue, anti-aging effects; Can strengthen immunologic function, strengthen metabolism; There are blood sugar lowering and cardiotonic.For lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few; The polydipsia of quenching one's thirst; Weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN; Deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair.

Radix Adenophorae and Radix Glehniae: Radix Adenophorae belongs to campanulaceae, Radix Glehniae belongs to Umbelliferae; Radix Adenophorae is sweet light, and property is flat, and Radix Glehniae is sweet cold; The gas of Radix Adenophorae tonifying the lung spleen, is applicable to deficiency of both the splenic and pulmonary QI, fatigue and weakness, lack of appetite, spontaneous perspiration, light red tongue, arteries and veins weak person; The kind the moon of supporting lung stomach of Radix Glehniae, is applicable to calentura later stage or prolonged illness yin asthenia generating intrinsic heat, dry cough, and expectorant is few, low grade fever, xerostomia, red tongue, tongue is few, thready pulse weak person.

Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Function, liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapse hidroschesis in addition also have promoting the production of body fluid to quench thirst.Be used for, soreness of waist and knee joint dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating collapse, interior-heat is quenched one's thirst.

Caulis Spatholobi: property hardship, micro-sweet, warm, to return liver, pass through, effect circulation of qi promoting is enriched blood, regulating menstruation, relaxing muscles and tendons and activating QI and blood in the collateral." herbal guiding principle day picks up any lost article from the road ": " its rattan is invigorated blood circulation most, warm waist knee joint, paralysis." study and find that Chinese medicine chicken Caulis seu Radix Schisandrae Henryi monomer SS8 has obvious stimulation effect to the propagation of bone marrow depression mouse hemopoietic CFU-GM (CFU-GM, CFU-E, BFU-E, CFU-meg), and have regular hour, dosage correlation.Research discovery, Caulis Spatholobi extract is external has the effect of spectrum growth inhibited to tumor cell line, and flavone compound may be its antineoplastic effective composition.

Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.

Rhizoma dioscoreae: sweet in the mouth, property is flat.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.

The Rhizoma Atractylodis Macrocephalae: property is sweet, bitter, warm, returns spleen, stomach warp, effect invigorating the spleen and benefiting QI, and dampness diuresis, hidroschesis, antiabortive, be described as strong board the first key medicine of spleen QI invigorating by forefathers.

Radix Glycyrrhizae: property is sweet flat, GUIXIN, lung, spleen, stomach warp, effect invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Pharmacological research shows that Radix Glycyrrhizae has antitumor, antioxidation, antiviral, the effect such as protects the liver.

Detailed description of the invention

Embodiment 1, a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, comprise following component raw material: 20 grams of the Radixs Astragali, 10 grams of Radix Angelicae Sinensis, 20 grams of Radix Codonopsis, 20 grams, Colla Corii Asini, 10 grams, Radix Rehmanniae Preparata, 10 grams of Rhizoma Polygonatis, 10 grams of Radix Adenophoraes, 10 grams of Radix Glehniaes, 10 grams of Fructus Corni, 10 grams of Caulis Spatholobis, 10 grams of Radix Ophiopogonis, 10 grams of Rhizoma dioscoreaes, 10 grams of the Rhizoma Atractylodis Macrocephalaes, 5 grams of Radix Glycyrrhizae Preparatas.

Be decocted in water for oral dose, potion on the one, takes at twice.

Embodiment 2, a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, comprise following component raw material: 30 grams of the Radixs Astragali, 20 grams of Radix Angelicae Sinensis, 30 grams of Radix Codonopsis, 30 grams, Colla Corii Asini, 15 grams, Radix Rehmanniae Preparata, 15 grams of Rhizoma Polygonatis, 15 grams of Radix Adenophoraes, 15 grams of Radix Glehniaes, 15 grams of Fructus Corni, 15 grams of Caulis Spatholobis, 20 grams of Radix Ophiopogonis, 20 grams of Rhizoma dioscoreaes, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 8 grams of Radix Glycyrrhizae Preparatas.

Be decocted in water for oral dose, potion on the one, takes at twice.

Embodiment 3, a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, comprise following component raw material: 25 grams of the Radixs Astragali, 15 grams of Radix Angelicae Sinensis, 25 grams of Radix Codonopsis, 25 grams, Colla Corii Asini, 12 grams, Radix Rehmanniae Preparata, 12 grams of Rhizoma Polygonatis, 12 grams of Radix Adenophoraes, 12 grams of Radix Glehniaes, 12 grams of Fructus Corni, 12 grams of Caulis Spatholobis, 15 grams of Radix Ophiopogonis, 15 grams of Rhizoma dioscoreaes, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 6 grams of Radix Glycyrrhizae Preparatas.

Be decocted in water for oral dose, potion on the one, takes at twice.

Embodiment 4, a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, comprise following component raw material: 24 grams of the Radixs Astragali, 18 grams of Radix Angelicae Sinensis, 18 grams of Radix Codonopsis, 30 grams, Colla Corii Asini, 11 grams, Radix Rehmanniae Preparata, 12 grams of Rhizoma Polygonatis, 13 grams of Radix Adenophoraes, 13 grams of Radix Glehniaes, 14 grams of Fructus Corni, 15 grams of Caulis Spatholobis, 17 grams of Radix Ophiopogonis, 18 grams of Rhizoma dioscoreaes, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 8 grams of Radix Glycyrrhizae Preparatas.

Be decocted in water for oral dose, potion on the one, takes at twice.

Embodiment 5, a kind of Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, comprise following component raw material: 26 grams of the Radixs Astragali, 12 grams of Radix Angelicae Sinensis, 22 grams of Radix Codonopsis, 26 grams, Colla Corii Asini, 15 grams, Radix Rehmanniae Preparata, 14 grams of Rhizoma Polygonatis, 11 grams of Radix Adenophoraes, 11 grams of Radix Glehniaes, 14 grams of Fructus Corni, 12 grams of Caulis Spatholobis, 13 grams of Radix Ophiopogonis, 10 grams of Rhizoma dioscoreaes, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 7 grams of Radix Glycyrrhizae Preparatas.

Be decocted in water for oral dose, potion on the one, takes at twice.

Test example

1. clinical data

Choose at random patient's 100 examples after chemicotherapy, at 35～75 years old age, 53 years old mean age, all tumor patients are all made a definite diagnosis through histopathology and/or cytology, and patient all accepts chemotherapy and/or radiotherapy.

All patients are divided into test group and matched group at random, every group of 50 examples.

2. Therapeutic Method

Test group gives Chinese medicine composition of the present invention, oral, and every day, potion, took at twice, within one month, is a course for the treatment of, finishes rear observed result the course for the treatment of.

Matched group only carries out normal nutritional rehabilitation, and then two groups are analyzed.

3. result

3.1 tcm syndrome curative effect evaluations

3.1.1 curative effect judgement

Effective: the symptom of traditional Chinese medical science disease QI and blood deficiency, inappetence, spiritlessness and weakness, deficiency of QI with disinclination to talk is significantly improved;

Effective: the symptom of traditional Chinese medical science disease QI and blood deficiency, inappetence, spiritlessness and weakness, deficiency of QI with disinclination to talk is improved obviously;

Invalid: the symptom of traditional Chinese medical science disease QI and blood deficiency, inappetence, spiritlessness and weakness, deficiency of QI with disinclination to talk is without improvement;

3.1.2 therapeutic outcome

Effective 24 examples of test group, effective 26 examples, invalid 0 example, improving total effective rate is 100.0%; Effective 8 examples of matched group, effective 12 examples, invalid 30 examples, total effective rate is 40.0%.

3.2 platelet rising curative effect evaluations

3.2.1 curative effect judgement:

It is effective: more than in one week, platelet rises to 100*109/L.

It is effective: more than in two weeks, platelet rises to 100*109/L; Or platelet has gone back up to 2 times; Or 2 times above but more than not rising to 100*109/L yet.

Invalid: not reach effective and effective evaluation criteria.

3.2.2 therapeutic effect:

Effective 18 examples of test group, effective 27 examples, invalid 5 examples, total effective rate is 90%.

Effective 7 examples of matched group, effective 15 examples, invalid 28 examples, total effective rate is 44%.

3.3 pairs of leukocytic curative effect evaluations of T

3.3.1 curative effect judgement

Effective: continuous 2 numeration of leukocyte >=4.0 × 109/L after treatment;

Effective: total white blood cells < 4.0 × 109/L after treatment, but than (0.5～the 1.0) × 109/L that rises before treatment;

Invalid: leukocyte is without obvious raising;

3.3.2 therapeutic outcome

Test group leucocytosis total effective rate is 96.0%, and matched group total effective rate is 68.0%.

As can be seen here, Chinese medicine composition of the present invention can obviously improve the symptoms such as traditional Chinese medical science insufficiency of vital energy and blood and inappetence, has the effect that promotes rehabilitation after patient chemicotherapy and improve patients ' life quality.Be described further in conjunction with concrete case:

Case 1, Zhang, female, 61 years old, patient diagnosis was carcinoma of corpus uteri, gives chemotherapy, after chemotherapy, card is shown in: shallow complexion, anorexia, vomiting is felt sick, pale tongue, the few weary Tianjin of tongue, deep-thready pulse.In treatment, give the present invention: every day potion, coordinate nutritious food, every day three times, within one month, be a course for the treatment of, after the course for the treatment of, patient's diet improve, have rosy cheeks, vomiting alleviates, detect indices, reached clinical improvement.

Case 2, Lee, man, 65 years old, after lung cancer chemotherapy 2 weeks, card was shown in: the lazy speech of breathing hard, health is become thin, and vomiting is felt sick, pale tongue, tongue shells, thready and weak pulse; In treatment, give every day of the present invention potion, coordinate nutritious food, every day three times, within one month, be a course for the treatment of, after the course for the treatment of, patient's diet improves, it is red that complexion turns, vomiting alleviates, and detects indices, has arrived clinical improvement.

Claims (2)

1. for a Chinese medicine composition for rehabilitation after tumor patient chemicotherapy, it is characterized in that, by weight, comprise following component raw material: Radix Astragali 20-30 part, Radix Angelicae Sinensis 10-20 part, Radix Codonopsis 20-30 part, Colla Corii Asini 20-30 part, Radix Rehmanniae Preparata 10-15 part, Rhizoma Polygonati 10-15 part, Radix Adenophorae 10-15 part, Radix Glehniae 10-15 part, Fructus Corni 10-15 part, Caulis Spatholobi 10-15 part, Radix Ophiopogonis 10-20 part, Rhizoma dioscoreae 10-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Glycyrrhizae Preparata 5-8 part.

2. the Chinese medicine composition for rehabilitation after tumor patient chemicotherapy as claimed in claim 1, is characterized in that, by weight, comprise following component raw material: 25 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 25 parts of Radix Codonopsis, 25 parts, Colla Corii Asini, 12 parts, Radix Rehmanniae Preparata, 12 parts of Rhizoma Polygonatis, 12 parts of Radix Adenophoraes, 12 parts of Radix Glehniaes, 12 parts of Fructus Corni, 12 parts of Caulis Spatholobis, 15 parts of Radix Ophiopogonis, 15 parts of Rhizoma dioscoreaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Radix Glycyrrhizae Preparatas.