CN103100072B - Traditional Chinese medicine composition for treating proctitis and appendicitis, and restraining rectum cancer - Google Patents
Traditional Chinese medicine composition for treating proctitis and appendicitis, and restraining rectum cancer Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition comprising the materials in parts by weight: 6-15 parts of radix bupleuri, 6-15 parts of hyacinth bean, 6-15 rhizoma cyperi, 10-20 parts of immature bitter orange, 6-15 parts of pinellia ternate, 6-15 parts of Tuckahoe, 10-15 parts of rhizoma zingiberis, 10-15 parts of coptis chinensis, 15-20 parts of smoked plum, 3-6 parts of caulis akebiae, 2-4 parts of liquorice, and 6-15 parts of root of kudzu vine. The traditional Chinese medicine composition is mainly used for preparing a medicament for treating proctitis and appendicitis, and restraining rectum cancer. The traditional Chinese medicine composition treats both symptoms and root causes on the basis of the principle of syndrome differentiation treatment of the traditional Chinese medicine, treats excess and deficiency, thoroughly adjusts interior and exterior, adjusts the degree of urgency, filters, regulates the flow of vital energy and eliminates heat, and detoxifies and removes natural plant medicament. The traditional Chinese medicine composition is prepared from the components in theory of traditional Chinese medicine according to certain proportion. The traditional Chinese medicine composition which is significant in curative effect and low in cost for treating proctitis and appendicitis, and restraining rectum cancer is provided by the invention. The traditional Chinese medicine composition is free of toxic and side effects, and can be safely and conveniently used by a sufferer.
Description
Technical field
The present invention relates to field of medicaments, particularly the Chinese medicine composition for the treatment of proctitis, cecitis and inhibition rectal cancer.
Background technology
Along with the raising of people's living standard and the change of life style, digestive tract disease is one of common clinical, and sickness rate is ascendant trend year by year, especially enteritis.Enteritis is gastroenteritis, proctitis and the colitis that antibacterial, virus, fungus and parasite etc. cause.Main manifestations has nauseating, vomiting, stomachache, diarrhoea, Xishui just or mucopurulent bloody stool clinically.Enteritis, by course of disease length difference, is divided into acute and chronic two classes.The chronic enteritis course of disease generally more than two months, clinical chronic bacillary dysentery, chronic amebic dysentery, schistosomicide, nonspecific ulcerative colitis and the limit office enteritis etc. of common are.Fall ill hundred million person-times of about 30-50 of the annual enteritis in the whole world, especially taking developing country's sickness rate and case fatality rate as high, particularly child.According to World Health Organization's statistics, in developing country, chronic diarrhea is the infectious disease that child morbidity is the highest, and case fatality rate approximately 20 ‰ only, in Asia, Africa and Latin America area, will be seized approximately 4,600,000 infant life every year.
Proctitis is a kind of common enteritis, mostly is chronic proctitis, easily outbreak repeatedly, and it is difficult to cure, and a lot of proctitis patients have been caused to no small puzzlement.Proctitis is because diet is careless, as excessive drinking, and the food that excessive edible zest is strong etc., the medicine of long-term taking fat-reducing improperly, anal corrosive medicine is too much, and antibacterial infection etc. causes.Only mucosa inflammation of the lighter, severe one is involved tela submucosa, flesh layer, and even rectum surrounding tissue is that a part of mucous membrane of rectum is got involved sometimes, and the whole inflammation of mucous membrane of rectum sometimes also may be involved mucous membrane of colon and also produce inflammation.The traditional Chinese medical science thinks that proctitis and " damp and hot interior pestilence ", " retention of food and drink ", " weakness of the spleen and stomach " are relevant with " malnutrition due to parasitic infestation humidity hysteresis ".Proctitis be common in have a delicate constitution lower for the resistance, the heart, lung, liver, gastroenteropathy, respiratory tract infection etc., constipation, diarrhoea, hemorrhoid, anorectal region prolapsus, anal fistula, polyposis, anorectal stricture, rectal neoplasm, rectal injury, foreign body etc., all can make rectum inflammation, the serious hospital that need go at once carries out operative treatment.
Although rectum inflammation is at rectum position, but its inflammation can affect whole intestinal, long-term proctitis stimulates, and can form the pathological changes such as ulcer.Rectum be stool must through last passage, long-term inflammatory stimulus, not only can produce various pathogenic bacterium, also can make stool in carcinogen be activated, further cause the canceration of rectum cell.
Cecitis is different from general enteritis, is one of modal cause of disease of acute abdominal pain, and everyone on average has 7% probability that cecitis can occur in life, with ten to 30 years old at most, five years old following and 50 years old relatively rare above.Cecitis is that vermiform appendix is obstructed in the outlet of caecum mostly, due to secondary antibacterial infects; But separately have 30% case to have no obstruction, its inflammation may be because of due to virus, parasite or antibacterial infection, wound or the rear feces of operating on be detained.Clinical manifestation pit of the stomach place or umbilicus fuzzy pain around before this conventionally, then shifts toward Right Lower Abdomen gradually, with asthenopyra, feel sick, vomiting, the symptom such as tired.If treatment is not in time, the concurrent popularity peritonitis of meeting, severe patient may cause septicemia and death, in recent years, clinical onset rate has the trend of continuous rising.
Modern medicine, to clinical a certain symptom treatment, is often difficult to produce a desired effect, and can not find suitable Therapeutic Method.Various enteritis, especially chronic enteritis, because of its cause of disease complexity, the course of disease is longer, without specific medicament, western medical treatment poor effect, toxic and side effects is many.Although various Western medicine preparations successful in a short time, preparation is expensive, needs long-term taking to maintain treatment, and patient's economic pressures are large.During as some hormone medicines and coupling immunomodulator oral medication chronic enteritis, remarkable to short-term relief of symptoms effect, but long-term taking can produce the side effect such as moon face, acne, insomnia, the reduction of body anti-infection ability, and can not prevent recurrence; Immunomodulator is owing to having cytotoxic effect, and prolonged application can cause Liver and kidney toxicity, and the serious consequences such as leukopenia, so medication need be careful.Seeing a doctor in tcm treatment according to syndrome differentiation to chronic disease is desirable thinking, although conventional Chinese medicinal formulae and dosage form has certain curative effect at present, and neither be very desirable.Various Chinese medicinal formulaes may be limited to crowd's situation difference of concrete observation, and the clinical observation deficiency of long-term larger case load, causes curative effect very unstable, are difficult to promote and fixing prescription.
These situations show, existing treatment enteritis, is specially proctitis and cecitis, and Western medicine toxic and side effects used is large, disturb the physiological function of the each system of whole body; General facing with Chinese medicine is long the course for the treatment of, and DeGrain, is unfavorable for patient physiological and psychological repair in trauma.So a kind of evident in efficacy, stable in the urgent need to developing, and toxic and side effects is little, inexpensive easy-to-use pharmaceutical preparation.
Summary of the invention
Object of the present invention is exactly for the above-mentioned problem that existing treatment enteritis exists in clinical, and a kind of convenient effective Chinese medicine composition is provided.From the physiological characteristics of intestinal and the pathology of enteritis, improve the yin or yang excess situation partially declining in body, the spleen and stomach regulating, Liver and kidney, make QI and blood battalion and unimpeded, and Chinese medicine all contains micro-mineral element in addition, enter after human body, select its effective ingredient for body, and participate in human body metabolism, nurse one's health on the whole the balance of yin-Yang, internal organs, QI and blood, immunologic function is improved, get rid of illness and consolidate.Again because Chinese herbal medicine is less to human body side effect, and can treating both the principal and secondary aspects of a disease, therefore select treatment by Chinese herbs intestinal tract disease, be effective selection.
The present invention selects Radix Bupleuri, Seem Lablab Album, Rhizoma Cyperi, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis, Rhizoma Coptidis, Fructus Mume, Caulis Akebiae, Radix Glycyrrhizae, 12 kinds of Chinese medicines of Radix Puerariae to combine, the principle counteracting each other according to Chinese medicine, these medicines are effectively combined, make each efficacy of drugs produce synergism, thereby reach heat clearing and damp drying, effect of QI and blood regulating, improves the yin or yang excess situation partially declining in body, makes taste, Liver and kidney battalion and degree of having.Wherein, Radix Bupleuri toil is slightly cold, and has that expelling pathogenic factors from the exterior expels the heat-evil, a merit of dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; The sweet light gentleness of Seem Lablab Album, can spleen invigorating and in, the removing dampness of relieving summer heat; The pungent micro-hardship of Rhizoma Cyperi is sweet, the resolving depression of can regulating the flow of vital energy, treating the liver discomfort in the stomach, depression of QI; Fructus Aurantii Immaturus bitter cold, can dispelling the stagnated QI, loose painful abdominal mass, rush down expectorant, removing food stagnancy, control distension and fullness of the chest and abdomen; The Rhizoma Pinelliae is warm in nature, acrid in the mouth, can drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the painful abdominal mass that disappears is loose; Poria sweet in the mouth, light flat, enters the heart, lung, spleen channel, has effect of eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Rhizoma Zingiberis is hot, warming spleen and stomach for dispelling cold, can recuperating depleted YANG promotes blood circulation, warming the lung to resolve fluid-retention; Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication; Fructus Mume is sour and astringent, the kind convergence of merit, on can astringe the lung gas, the puckery large intestine of lower energy, enter that stomach can promote the production of body fluid again, relieving colic caused by ascaris; Caulis Akebiae nature and flavor hardship, cool, can pathogenic fire purging row water, promoting blood circulation, dissipation irritable feverish sensation in the chest, sore throat pharyngalgia; Radix Glycyrrhizae sweet in the mouth, flat, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Radix Puerariae sweet in the mouth, pungent, expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.
Drug dose of the present invention, counts: Radix Bupleuri 6-15 part, Seem Lablab Album 6-15 part, Rhizoma Cyperi 6-15 part, Fructus Aurantii Immaturus 10-20 part, Rhizoma Pinelliae 6-15 part, Poria 6-15 part, Rhizoma Zingiberis 10-15 part, Rhizoma Coptidis 10-15 part, Fructus Mume 15-20 part, Caulis Akebiae 3-6 part, Radix Glycyrrhizae 2-4 part, Radix Puerariae 6-15 part by weight.
Be preferably: 10 parts of Radix Bupleuri, 10 parts, Seem Lablab Album, 10 parts of Rhizoma Cyperis, 15 parts of Fructus Aurantii Immaturuss, 10 parts of the Rhizoma Pinelliaes, Poria 6-15 part, 13 parts of Rhizoma Zingiberiss, 13 parts of Rhizoma Coptidis, 18 parts of Fructus Mumes, 5 parts of Caulis Akebiaes, 3 parts, Radix Glycyrrhizae, 10 parts of Radix Puerariaes.
Chinese medicine composition of the present invention is mainly the application in the medicine for the preparation for the treatment of proctitis, cecitis and inhibition rectal cancer.
The dosage form of Chinese medicine composition of the present invention is powder, tablet, medical herbs decoction, colloid or oral liquid formulations.
The preparation method of the powder of described Chinese medicine composition, comprises the following steps:
1) pulverize: by described component by proportioning mix, drop into pulverizer be ground into fine powder, to granularity be 80-110 order;
2) mix: by step 1) gained fine powder drop into mixing and blending machine fully mix;
3) heating: by step 2) gained heats 25-40 minute at 65-80 DEG C;
4) store: by step 3) after gained is cooling, packed or bottled, be placed in shady and cool dry place.
The preparation method of the medical herbs decoction of described Chinese medicine composition, comprises the following steps:
1) get the raw materials ready: after described component is mixed by proportioning, pulverize, every dose of prepared slices of Chinese crude drugs are no longer than 3cm;
2) soaking: by step 1) gained is placed in the container of boiling medicine, and with soaking 20-30 minute in cold water, water consumption was soaked powder 1-3cm;
3) boil medicine: by step 2) gained first decocts to abundant boiling 1-3 minute with vigorous fire, then receives to slow fire, decocts 30-60 minute;
4) medication: by step 3) handy antiseptic gauze filters to obtain required medicinal liquid, pours in cup warm taking into.
In the preparation process of medical herbs decoction, the used container of boiling medicine is marmite or enamel ware, should not use iron pan or aluminum pot, in order to avoid contained part active ingredient substance and the metalware generation chemical reaction of Chinese medicine affects medicinal effects.
The water used of boiling medicine is cold water, well water or spring water.Due to cold water be generally by tap water boil rear cooling come, and tap water has passed through bleaching powder processing, contains a large amount of chlorine elements, if directly boil with tap water, chloride ion may with Chinese medicine ingredients generation chemical reaction, the drug effect of Chinese medicine is impacted.Also can directly take well water or spring water boils, effect is better.
The present invention is the principle based on tcm treatment according to syndrome differentiation, treating both the principal and secondary aspects of a disease, and deficiency and excess is also controlled, inside and outside logical tune, emergency is taken in concurrently, and filtering out regulates the flow of vital energy expels the heat-evil, and the natural plant of detoxicating and resolving stagnation of pathogens, according to theory of Chinese medical science prescription, is prepared from according to certain amount proportioning.The Chinese medicine composition of a kind for the treatment of proctitis evident in efficacy, with low cost, cecitis and inhibition rectal cancer is provided, and without any side effects, patient uses safety, convenient.
Detailed description of the invention
For many years, be the good effect of checking medicament of the present invention, inventor has carried out a large amount of tests clinically, is being applicable to, after the patient of surrounding area, place, inventor residence, to have received obvious effect.According to the situation of accepting patient for medical treatment, be summarized as follows: accept patient's totally 62 examples for medical treatment, wherein, and male patient's 38 examples, female patient 24 examples, M-F is 1.6: 1; 14-35 age, 18 examples year, 36-65 year 44 examples.Concrete, proctitis patient's 22 examples, cecitis patient's 34 examples, rectal cancer patient 6 examples.
Now select part clinical experiment report as follows:
1. diagnosis and treatment evaluation criteria:
Recovery from illness: clinical symptom disappearance, drug withdrawal has no recurrence half a year.
Effective: symptom alleviates, but do not take a turn for the better completely.
Invalid: symptom is without obvious change.
2. diagnostic criteria: Syndrome Differentiation of Traditional Chinese Medicine, doctor trained in Western medicine inspection diagnosis effect.
3. Therapeutic Method: Chinese medicine composition of the present invention is made to powder, tablet, medical herbs decoction, colloid or oral liquid formulations and take.
4. medicinal method: dosage of the present invention depends on the factors such as concrete dosage form, patient age, body weight and health status, because the dosage form of described Chinese medicine composition can be powder, tablet, medical herbs decoction, colloid or oral liquid formulations.Therefore concrete used in amounts will, according to practical situations such as patient's pathological characters, the concrete causes of disease, due to illness treat.
As medicinal guidance: get Radix Bupleuri 6-15g, Seem Lablab Album 6-15g, Rhizoma Cyperi 6-15g, Fructus Aurantii Immaturus 10-20g, Rhizoma Pinelliae 6-15g, Poria 6-15g, Rhizoma Zingiberis 10-15g, Rhizoma Coptidis 10-15g, Fructus Mume 15-20g, Caulis Akebiae 3-6g, Radix Glycyrrhizae 2-4g, Radix Puerariae 6-15g.After above-mentioned middle spice is mixed, after boiling by the preparation method of medical herbs decoction, take, sooner or later respectively once.
Preferably, the amount of each component is: Radix Bupleuri 10g, Seem Lablab Album 10g, Rhizoma Cyperi 10g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae 10g, Poria 6-15g, Rhizoma Zingiberis 13g, Rhizoma Coptidis 13g, Fructus Mume 18g, Caulis Akebiae 5g, Radix Glycyrrhizae 3g, Radix Puerariae 10g.
5. clinical data gathers:
Followingly choose a model case and illustrate:
Model case 1: Liu, female, 40 years old, the not molding of suffering from abdominal pain, suffer from diarrhoea, defecate, time the phenomenon of having blood in stool, the diseases such as borborygmus and defecation are smooth, malaise, aversion to cold, giddy, remission after hospital's inflammation diminishing and fluid supplementing.Usually recurrence often, slightly improper diet, as eat a little marors and will defecate not freely, often with Mucous Stool, be converted into afterwards bloody purulent stool, after medical check, be diagnosed as proctitis.Hospital uniform Western medicine, the treatment such as coloclysis is all effective, but after drug withdrawal, gastrointestinal slightly irriate will recur.Through using following allocation:
Radix Bupleuri 6g, Seem Lablab Album 6g, Rhizoma Cyperi 6g, Fructus Aurantii Immaturus 10g, Rhizoma Pinelliae 6g, Poria 6g, Rhizoma Zingiberis 10g, Rhizoma Coptidis 10g, Fructus Mume 15g, Caulis Akebiae 3g, Radix Glycyrrhizae 2g, Radix Puerariae 6g.After above-mentioned middle spice is mixed, be boiled into medical herbs decoction and take, sooner or later respectively once.
Take medicine after ten days, patient stool is just shaped, and times of defecation reduces; After taking medicine one month, bloody purulent stool phenomenon disappears; Take medicine and remove after two months examination in hospital, it is normal that intestinal mucosa recovers; Continue to strengthen and take medicine one month, patient's recovery from illness, does not recur again.
Model case 2: Zhang, man, 42 years old, medication was swollen and ache around umbilicus before two weeks, and sensation is felt sick, anorexia, thinks oneself as stomachache.There is afterwards fever, do not move back, and constipation day after day, through intramuscular injection penicillin 3 days, had no improvement, showed as obnubilation, down in spirits, expression is indifferently.Through diagnosis and treatment, its guarding, tenderness, squamous and dry skin, right lower extremity is curl and sleeping, and pulse condition is heavy thin, and tongue fur root is thin and yellow greasy.Through using following allocation:
Radix Bupleuri 15g, Seem Lablab Album 15g, Rhizoma Cyperi 15g, Fructus Aurantii Immaturus 20g, Rhizoma Pinelliae 15g, Poria 15g, Rhizoma Zingiberis 15g, Rhizoma Coptidis 15g, Fructus Mume 20g, Caulis Akebiae 6g, Radix Glycyrrhizae 4g, Radix Puerariae 15g.After above-mentioned middle spice is mixed, be boiled into medical herbs decoction and take, sooner or later respectively once.
Take medicine of the present invention one week, patient's free movement of the bowels, abdominal part pain is gradually light, and guarding sense slows down, and tenderness slackens, and starts a small amount of diet; After 10 days, stomachache is slight, and body temperature is gradually normal, and stomach is received and turned fragrant; Take this composition of medicine 20, it is normal that sign is recovered, patient's recovery from illness.
Model case 3: Zhao, man, 52 years old, clinical disease was that defecation is irregular, stool be out of shape, attenuates, tenesmus, the amount of having blood in stool are large, has pain when abdominal part, with losing weight, lassitude, appetite decline, it is reported and once suffers from proctitis.Because discontinuity abdominal colic increases the weight of, seek medical advice after a period of time to hospital, above symptom does not alleviate, after be diagnosed as rectal cancer.Patient faces huge health misery and stress, and because the economic pressures of seeking medical advice are excessive, patient goes home to recuperate then.After with attempt phychology used subordinate's Chinese medicine formula:
Radix Bupleuri 10g, Seem Lablab Album 10g, Rhizoma Cyperi 10g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae 10g, Poria 6g, Rhizoma Zingiberis 13g, Rhizoma Coptidis 13g, Fructus Mume 18g, Caulis Akebiae 5g, Radix Glycyrrhizae 3g, Radix Puerariae 10g.After above-mentioned middle spice is mixed, be boiled into medical herbs decoction and take, sooner or later respectively once.
Take this medicine after 1 month, patient's situation of having blood in stool slows down, and the number of times of having blood in stool reduces, and appetite slightly increases; After 3 months, tenesmic situation obviously reduces, and the interval time of stomachache is elongated, and stool is shaped, color shoals; After 8 months, patient's appetite increases, and has felt energetically with it, and spirit is got up gradually, and other symptoms disappear substantially; Continue to strengthen and take this combination medicine, after 1 year, before weight in patients is more sick, increase to some extent all transference cures.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (10)
1. be applicable to the Chinese medicine composition of enteritis, it is characterized in that, made by the former medicine of following weight portion: 6-15 parts of Radix Bupleuri, 6-15 parts, Seem Lablab Album, 6-15 parts of Rhizoma Cyperis, 10-20 parts of Fructus Aurantii Immaturuss, 6-15 parts of the Rhizoma Pinelliaes, 6-15 parts, Poria, 10-15 parts of Rhizoma Zingiberiss, 10-15 parts of Rhizoma Coptidis, 15-20 parts of Fructus Mumes, 3-6 parts of Caulis Akebiaes, 2-4 parts, Radix Glycyrrhizae, 6-15 parts of Radix Puerariaes.
2. the Chinese medicine composition that is applicable to enteritis according to claim 1, it is characterized in that, made by the former medicine of following weight portion: 10 parts of Radix Bupleuri, 10 parts, Seem Lablab Album, 10 parts of Rhizoma Cyperis, 15 parts of Fructus Aurantii Immaturuss, 10 parts of the Rhizoma Pinelliaes, 6-15 parts, Poria, 13 parts of Rhizoma Zingiberiss, 13 parts of Rhizoma Coptidis, 18 parts of Fructus Mumes, 5 parts of Caulis Akebiaes, 3 parts, Radix Glycyrrhizae, 10 parts of Radix Puerariaes.
3. the application of the Chinese medicine composition described in claim 1 or 2 any one in the medicine for the preparation for the treatment of proctitis.
4. the Chinese medicine composition described in claim 1 or 2 any one is in the application for the preparation of in the typhlitic medicine for the treatment of.
5. the application of the Chinese medicine composition described in claim 1 or 2 any one in the medicine for the preparation of inhibition rectal cancer.
6. the preparation of the Chinese medicine composition that is applicable to enteritis described in claim 1 or 2 any one, is characterized in that, the dosage form of described Chinese medicine composition is powder, tablet, medical herbs decoction or oral liquid formulations.
7. the preparation of Chinese medicine composition according to claim 6, is characterized in that, the preparation method of described Chinese medicine composition composition powders, comprises the following steps:
1) pulverize: by described component by proportioning mix, drop into pulverizer be ground into fine powder, to granularity be 80-110 orders;
2) mix: step 1) gained fine powder is dropped into mixing and blending machine and fully mix;
3) heating: by step 2) gained heats 25-40 minutes at 65-80 DEG C;
4) store: after cooling step 3) gained, packed or bottled, be placed in shady and cool dry place.
8. the preparation of Chinese medicine composition according to claim 6, is characterized in that, the preparation method of the medical herbs decoction of described Chinese medicine composition, comprises the following steps:
1) get the raw materials ready: after described component is mixed by proportioning, pulverize, every dose of prepared slices of Chinese crude drugs are no longer than 3cm;
2) soak: step 1) gained is placed in to the container of boiling medicine, and with soaking in cold water 20-30 minutes, water consumption was soaked powder 1-3cm;
3) boil medicine: by step 2) gained first decocts to abundant boiling 1-3 minutes with vigorous fire, then receives to slow fire, decocts 30-60 minute;
4) medication: the handy antiseptic gauze of step 3) is filtered to obtain to required medicinal liquid, pour in cup, warm taking.
9. the preparation of Chinese medicine composition according to claim 8, is characterized in that, described in the container of boiling medicine be marmite or enamel ware.
10. the preparation of Chinese medicine composition according to claim 8, is characterized in that, the water used of boiling medicine is cold water, well water or spring water.
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