CN102908396B - Chinese medicinal composition for promoting sleeping and preparation method thereof - Google Patents
Chinese medicinal composition for promoting sleeping and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicaments, and discloses a Chinese medicinal composition for promoting sleeping and a preparation method thereof. The Chinese medicinal composition is prepared from silk tree flower, jasmine flower, linden blossom and liquorice, and has the functions of calming and tranquilizing. All Chinese medicaments in the Chinese medicinal composition influence with one another, and are synergic to play the roles of calming and tranquilizing, prolonging sleeping time and improving sleeping quality, so that the Chinese medicinal composition is short in course of treatment and quick in response. The medicinal materials used in the invention are non-toxic, so that the Chinese medicinal composition is small in drug dependence after long-term use, and low in price, is suitable for patients with short term and long term insomnia, and has wide market prospect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of to there is Chinese medicine composition of hypnotic effect and preparation method thereof.
Background technology
Insomnia and sleep disorder are due to feelings will, diet internal injury, or after being ill and old, innate deficiency, the causes of disease such as timidness due to deficiency of the heart, cause lack of preservation of spirit or irritability, thus cause often obtaining the class disease that ortho sleep is feature.Insomnia is one of common clinical disease, shows as difficulty falling asleep, intermittently discontinuous, and wakes up prematurely, can not continue to sleep again, not have enough sleep, malaise after waking up, and asthenia is felt.Though insomnia does not belong to critical illness, but the imbalance of intestinal microbial population can be caused, cause constipation, diarrhoea, mottle seat skin ulcer, immunity of organisms declines, intestinal can not the phenomenon such as normal creepage of gastrointestinal functions, colour of skin flavescence, hinder people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even form the dependence to sleeping medicine, and the sleeping medicine of long-term taking can cause iatrogenic disease.
At present, the phenobarbital class Drug therapy insomnias such as many employings are both at home and abroad stable, estazolam, ALprazolanic, clonazepam, fludiazepam, these curative effect of medication are definite, initial stage can reach the effect of getting instant result, play number of times of awakening less night, increase the effect such as total sleep time, improving water flood quality, but long-term taking can produce certain side effect to health, produce drug resistance and dependency, there is the symptoms such as sleepy, drowsiness, weak, dizzy, also may occur ataxia time heavy dose of, temporaryly to forget and the untoward reaction such as disturbance of consciousness.And Chinese traditional treatment is from entirety, the basis of reinforce insufficiency and reduce excessiveness, adjustment internal organs negative and positive of qi and blood is aided with tranquilizing the mind, and clinical efficacy is good, side effect is little and medical material is all nontoxic can life-time service.
The traditional Chinese medical science claims insomnia for being insomnia, insomnia etc., with in pathogenic fire derived from stagnation of liver-QI, expectorant heat around, become silted up and disturb the basic pathogenesis for insomnia such as the mind, hyperactivity of fire caused by deficiency of YIN, deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy.Chinese patent drugs for treatment insomnia effect commercially available at present relaxes, and truly has certain curative effect, but compatibility is complicated mostly, the course for the treatment of of taking medicine is long, cure rate is low.Therefore, the Chinese medicine preparation taking compatibility simple, evident in efficacy is researched and developed significant to improving water flood.
Summary of the invention
In view of this, the object of the present invention is to provide that a kind of compatibility is simple, the Chinese medicine composition with hypnotic effect of Be very effective.
For realizing object of the present invention, the present invention adopts following technical scheme:
There is a Chinese medicine composition for hypnotic effect, be made up of the crude drug of following weight portion:
1 ~ 3 part, Flos Albiziae 1 ~ 5 portion of Flos Jasmini Sambac 1 ~ 5 part of Tilia europaea 1 ~ 3 portion of Radix Glycyrrhizae.
Chinese medical book is recorded: " yang-energy is most, cloudy arrogant, then blurring of vision; Cloudy gas is most, and yang-energy is contained, then awake." this be to sleep classic explanation, when yang-energy decline, cloudy gas rise time, will sleep be caused; When yang-energy is prosperous and powerful, during cloudy gas crock up, people will awaken.In addition, sleep also and liver, the heart, spleen, lung, kidney and the synergism between them closely related.Chinese medicine composition of the present invention, for bad formed main mechanism of sleeping, selects the four taste Chinese crude drugs such as Flos Albiziae, Flos Jasmini Sambac, Tilia europaea 1 ~ 3 part and Radix Glycyrrhizae to make, fundamentally negative and positive in control agent, calms and calms the nerves, hypnotic.
Wherein, Flos Albiziae, have another name called that silk tree is joyous, Flos Albiziae, velvet flowers tree, bird floss tree, be the dry inflorescence of leguminous plant Herba Albiziae Albizia julibrissin Durazz..Flos Albiziae is warm in nature, sweet-bitter flavor, nontoxic, GUIXIN, spleen channel, the effects such as tool resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, pathogenic wind expelling improving eyesight, promoting blood circulation and stopping pain, have calming effects simultaneously, are mainly used in the diseases such as treatment pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.
Flos Jasmini Sambac, having another name called a kind of apple flower, oblonga flower, is the flower of Oleaceae shrub plant jasmine.Flos Jasmini Sambac is put down, acrid in the mouth, sweet, has removing dampness for regulating stomach, effects such as resolving depression of regulating the flow of vital energy, and is mainly used in that taste turbid damp is not changed, eaten that gastral cavity is vexed less, the disease such as diarrhoea or dysentery stomachache.
Tilia europaea, has another name called Flos Tiliae, is the inflorescence of Tiliaceae plant tilia miqueliana.Tilia europaea is warm in nature, acrid in the mouth, sweet, enters lung meridian, has the effect such as relieving the exterior syndrome by diaphoresis, pain relieving spasmolytic, be mainly used in spasmolytic, convergence, cough-relieving, sharp brain, eliminate nasal obstruction, diuresis, make skin emolliency, reduce blood pressure, profit is neural, calm, promote diaphoresis, benefit body.
Radix Glycyrrhizae, another name Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae are dicotyledon pulse family Radix Glycyrrhizae (Glycyrrhizauralensis Fisch.), the root and rhizome of Glycyrrhiza inflata Bat. (G.inflata Bat.) or Glycyrrhiza glabra L. (G.glabra L.), be a kind of tonification Chinese herbal medicine, have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, grows and coughs lung moistening, and emergency is detoxified, and is in harmonious proportion hundred medicines.Clinical practice divides, and " life is used " is not with " processed with honey "." raw with " Radix Glycyrrhizae has another name called Radix Glycyrrhizae, SHENGCAO, Radix Glycyrrhizae, for crude drug removing impurity, cleans, runs through section and give birth to being used as medicine; " processed with honey " has another name called Radix Glycyrrhizae Preparata, Radix Glycyrrhizae Preparata, Radix Glycyrrhizae, Radix Glycyrrhizae (processed with honey), and Radix Glycyrrhizae tabellae Mel of making a living is mixed thoroughly, then fries to tack-free taking-up airing, is then used as medicine.Radix Glycyrrhizae of the present invention is Radix Glycyrrhizae, sweet in the mouth, property are flat, GUIXIN, lung, spleen, stomach warp, there is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, strong for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity.
Flos Albiziae described in the present invention, Flos Jasmini Sambac, Tilia europaea and Radix Glycyrrhizae well known to a person skilled in the art, can by commercial sources buy from a medical store obtain or by method disclosed in prior art cultivation, gathering obtains, its specification meets country or industry standard.Medical material used is all nontoxic simultaneously, and prolonged administration of drugs dependency is little, and cheap, is applicable to ordinary consumer and uses.
As preferably, Chinese medicine composition of the present invention, be made up of following raw material:
1.5 parts, Flos Albiziae 3 portions of Flos Jasmini Sambacs 3 parts of Tilia europaea 1.5 portions of Radix Glycyrrhizaes
Present invention also offers the preparation method of described Chinese medicine composition, pulverize rear mixing for getting 1 ~ 5 weight portion Flos Albiziae, 1 ~ 5 weight portion Flos Jasmini Sambac, 1 ~ 3 weight portion Tilia europaea and 1 ~ 3 weight portion Radix Glycyrrhizae and get final product.
Further, preparation method of the present invention also comprises the step of described raw material being carried out respectively to washing and drying.
Present invention also offers the clinical preparation of described Chinese medicine composition.Chinese medicine composition of the present invention can be added according to the demand of different patient that to prepare different dosage form be required various pharmaceutically conventional adjuvants by those skilled in the art, as disintegrating agent, lubricant, emulsifying agent, binding agent etc., with conventional method of Chinese medicinal, common dosage forms made by the acceptable adjuvant that add pharmaceutically direct or indirect through conventional machining.
Preferably, the clinical preparation of Chinese medicine composition of the present invention is granule or oral liquid, is easy to use, and with strong points, curative effect is obvious.
Using dosage and the using method of pharmaceutical composition of the present invention depend on factors, comprise the subjective judgment of the age of patient, body weight, sex, natural health situation, nutriture, the activity intensity of compound, service time, metabolic rate, the course of disease order of severity and diagnosis and treatment doctor.Those skilled in the art easily can determine using dosage and the using method of pharmaceutical composition according to above-mentioned factor.
Present invention also offers the health product comprising Chinese medicine composition of the present invention.
Preferably, the health product of Chinese medicine composition of the present invention are health tea.
There is the preparation method of the health tea of hypnotic effect, for Chinese medicine composition of the present invention being loaded tea bag and get final product described in present invention also offers.
The present invention is through clinical observation on the therapeutic effect, in 150 routine insomniacs, take Chinese medicinal composition granules of the present invention after 7 days, 136 cases got cured, cure rate accounts for 90.7%, take a turn for the better 11 examples, obvious effective rate accounts for 7.3%, and total effective rate is 98.0%, invalid 3 examples, inefficiency accounts for 2.0%, shows that the Chinese medicine composition with hypnotic effect of the present invention is evident in efficacy.In 180 routine insomniacs, use Chinese medicine composition health tea of the present invention, cure rate accounts for 85.0%, and effective percentage is 97.2%, shows that the Chinese medicine composition health tea with hypnotic effect of the present invention is evident in efficacy.In treated patient, do not have an example to occur untoward reaction, show Chinese medicine composition of the present invention and described Chinese medicine composition health tea nontoxic to human-body safety.
The invention provides a kind of Chinese medicine composition with hypnotic effect.Chinese medicine composition of the present invention is that raw material is prepared from by Flos Albiziae, Flos Jasmini Sambac, Tilia europaea and Radix Glycyrrhizae, in described Chinese medicine composition, each taste Chinese medicine influences each other, synergism, play the effect of well feeling at ease to repose, extend the length of one's sleep, improve sleep quality, improving water flood is evident in efficacy, short treating period, instant effect.The medical material used of the present invention is simultaneously all nontoxic, and life-time service drug dependence is little, and cheap, and the patient being applicable to short-term and chronic insomnia uses, and has wide market prospect.
Detailed description of the invention
The embodiment of the invention discloses and a kind of there is Chinese medicine composition of hypnotic effect and preparation method thereof.Those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention is described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope method as herein described is changed or suitably change with combination, realize and apply the technology of the present invention.
In order to understand the present invention further, be described in detail to the invention provides below in conjunction with embodiment.
Embodiment 1: the Chinese medicine composition with hypnotic effect of the present invention
Described Chinese medicine composition is made up of following crude drug: Flos Albiziae 1g, Flos Jasmini Sambac 5g, Tilia europaea 1g, Radix Glycyrrhizae 3g.
Preparation method is, after said medicine is washed respectively, dried, pulverizes, mix by weight ratio at normal temperatures and get final product.
Embodiment 2: the Chinese medicine composition with hypnotic effect of the present invention
Described Chinese medicine composition is made up of following crude drug: Flos Albiziae 5g, Flos Jasmini Sambac 1g, Tilia europaea 3g, Radix Glycyrrhizae 1g.
Preparation method is, after said medicine is washed respectively, dried, pulverizes, mix by weight ratio at normal temperatures and get final product.
Embodiment 3: the Chinese medicine composition with hypnotic effect of the present invention
Described Chinese medicine composition is made up of following crude drug: Flos Albiziae 3g, Flos Jasmini Sambac 3g, Tilia europaea 1.5g, Radix Glycyrrhizae 1.5g.
Preparation method is, after said medicine is washed respectively, dried, pulverizes, mix by weight ratio at normal temperatures and get final product.
Embodiment 4: the granule with the Chinese medicine composition of hypnotic effect of the present invention
The Chinese medicine composition of Example 3 gained mixes the obtained Chinese medicine granules with hypnotic effect of the present invention according to a conventional method with conventional adjuvant.
Embodiment 5: the oral liquid with the Chinese medicine composition of hypnotic effect of the present invention
The Chinese medicine composition of Example 3 gained mixes the obtained Chinese medicine oral liquid with hypnotic effect of the present invention according to a conventional method with conventional adjuvant.
Embodiment 6: the health tea with the Chinese medicine composition of hypnotic effect of the present invention
The Chinese medicine composition of Example 3 gained loads in tea bag and get final product.
Embodiment 7: the observation of curative effect of Chinese medicine composition of the present invention
300 routine insomniacs are divided into experimental group and matched group at random, often organize 150 examples, granule and the classical Chinese medicine prescription suanzaoren decoction of the Chinese medicine composition of Application Example 4 preparation are respectively treated.
Therapeutic Method: experimental group takes the granule of Chinese medicine composition of the present invention sooner or later, and treatments period stops other western medicines in treatment.Matched group takes classical Chinese medicine prescription suanzaoren decoction sooner or later, and treatments period stops other western medicines in treatment.
Observation of curative effect: the present invention achieves good curative effect clinically, in 150 routine insomniacs, takes Chinese medicinal composition granules of the present invention after 7 days, 136 cases got cured, cure rate accounts for 90.7%, and take a turn for the better 11 examples, and obvious effective rate accounts for 7.3%, total effective rate is 98.0%, and invalid 3 examples, inefficiency accounts for 2.0%.Matched group cure rate is that 67.3%, two groups of cure rates compare and have significant difference (P<0.05).
Embodiment 8: the clinical observation on the therapeutic effect of Chinese medicine composition of the present invention:
Permitted certain, man 50 years old, retired worker.For many years insomniac, every day has difficulty in going to sleep for a long time, sleeps more shallow, and dreaminess, Yi Xing, thus causes lean body mass, lassitude, is off one's feed, and often feels dizzy, mood is irritated.Use the granule that the embodiment of the present invention 4 is obtained, after using 1 week continuously, sleep stable, comparatively dark, the few dream of sleep, lassitude, the resolution of symptoms of being off one's feed; Continuous use is after 2 weeks, and sleep recovers normal, and insomnia disappears completely, happy, in high spirits.
Zhang, female 15 years old, middle school student.Because learning pressure suffers from insomnia 2 months, poor sleep, can not fall asleep, and cannot fall asleep the whole night time serious, listless, and mood is irritated, within second day, does not also have energy to learn.Use the granule that the embodiment of the present invention 4 is obtained, after taking 1 week continuously, various insomnia disappears, happy, in high spirits.
Lee, man 20 years old, university students.Suffer from insomnia existing 1 year, sleep more shallow, dreaminess.Use the granule that the embodiment of the present invention 4 is obtained, after taking 1 week continuously, various insomnia disappears, and sleeps stable, sleeps darker.
Embodiment 9: the clinical observation on the therapeutic effect of health tea of the present invention
Observe the curative effect of application health tea of the present invention.
Select case 180 example in outpatient service or ward, man 82 example, female 98 example, age circle, the course of disease was the shortest 2 months in 15 ~ 60 years old, the longest 10 years.
Therapeutic Method: use Chinese medicine composition health tea described in the embodiment of the present invention 6, use 2 weeks continuously, period stops using other Chinese medicine and western medicine and health product.
Therapeutic outcome: cure 153 examples, account for 85.0%; Effective 22 examples, account for 12.2%; Invalid 5 examples, account for 2.8%.
The explanation of above embodiment just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (9)
1. there is a Chinese medicine composition for hypnotic effect, it is characterized in that, be made up of the raw material of following weight portion:
1 ~ 3 part, Flos Albiziae 1 ~ 5 portion of Flos Jasmini Sambac 1 ~ 5 part of Tilia europaea 1 ~ 3 portion of Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1, is characterized in that, be made up of following raw material:
1.5 parts, Flos Albiziae 3 portions of Flos Jasmini Sambacs 3 parts of Tilia europaea 1.5 portions of Radix Glycyrrhizaes.
3. a preparation method for the Chinese medicine composition of sleeping, is characterized in that, gets 1 ~ 5 weight portion Flos Albiziae, 1 ~ 5 weight portion Flos Jasmini Sambac, 1 ~ 3 weight portion Tilia europaea and 1 ~ 3 weight portion Radix Glycyrrhizae and pulverizes rear mixing and get final product.
4. the Chinese medicine composition prepared of preparation method described in claim 3.
5. there is a Chinese medicine preparation for hypnotic effect, it is characterized in that, be made up of the Chinese medicine composition described in claim 1,2 or 4 and pharmaceutically acceptable adjuvant.
6. Chinese medicine preparation according to claim 5, it is characterized in that, it is granule or oral liquid.
7. comprise the health product of the Chinese medicine composition described in claim 1,2 or 4.
8. health product according to claim 7, it is characterized in that, it is health tea.
9. there is a preparation method for the health tea of hypnotic effect, it is characterized in that, compositions described in claim 1,2 or 4 loaded in tea bag and get final product.
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| CN105053421A (en) * | 2015-09-17 | 2015-11-18 | 上海秋橙新材料科技有限公司 | Tranquilizing tea |
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| CN101181382A (en) * | 2007-12-05 | 2008-05-21 | 姜莉蔚 | Chinese medicine emplastrum for soothing the mind to sleep |
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