CN1814153A - Medicine composition for preventing and treating breast cancer and preparing method - Google Patents

Medicine composition for preventing and treating breast cancer and preparing method Download PDF

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Publication number
CN1814153A
CN1814153A CN 200510061810 CN200510061810A CN1814153A CN 1814153 A CN1814153 A CN 1814153A CN 200510061810 CN200510061810 CN 200510061810 CN 200510061810 A CN200510061810 A CN 200510061810A CN 1814153 A CN1814153 A CN 1814153A
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radix
standby
ethanol
add
angelicae sinensis
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CN1814153B (en
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杨雄志
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NINGBO YUANZHI BIOTECHNOLOGY CO Ltd
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Abstract

The invention discloses a medicinal combination for preventing and curing breast cancer and the preparing method thereof, prepared of Mongolian Dandelion Herb, Ficus carica L, Radix Astragali, Chinese Angelica, Radix Asparagi, Fructus Aurantii Immaturus, Red Paeony Root, safflower, etc, and having functions of tonifying the liver and kidney, benefiting Qi and promoting blood circulation, and removing blood stasis and clearing meridian. And the preparing method includes the following steps of: weighing all raw materials in proportion, crushing and screening Mongolian Dandelion Herb, Chinese Angelica, and safflower into powder and reserving; taking Red Paeony Root, Ficus carica L, Radix Asparagi and adding in water to decoct twice, concentrating, making alcoholic sediment, recovering alcohol, and concentrating into extract; taking Fructus Aurantii Immaturus and Membranous Milkvetch Root and adding in alcohol to reflux twice, filtering, and concentrating into extract and reserving; mixing and heating the extracts, adding in Mongolian Dandelion Herb, Chinese Angelica and safflower powders, mixing, drying, screening, and making capsules. It is to be orally taken, convenient to use, tasting good, and low-cost,and as compared with the Western medicines of the same type, has advantages of reasonable formula, strict process, remarkable curative effect, no toxicity and side effect, easy to be accepted by patients, suitable to be taken long term, good curative effect, etc.

Description

Pharmaceutical composition of a kind of prevention and treatment breast carcinoma and preparation method thereof
Technical field
The present invention relates to field of medicaments, more particularly the present invention relates to pharmaceutical composition of a kind of prevention and treatment breast carcinoma and preparation method thereof
Background technology
Mastopathy is women's commonly encountered diseases, a frequently-occurring disease.Breast carcinoma is primary malignant tumor in whole world women, and have 7.9 ten thousand new cases every year approximately, accounts for whole women's malignant tumor sums 21%.Breast carcinoma average annual sickness rate in the whole world is 30.30/10 ten thousand, and the world population regulation is 32.97/10 ten thousand.China has nearly 300,000 women to die from tumor every year, and the death toll of cyclomastopathy canceration accounts for 1/4th of dead sum, and breast disease has become the main killer who jeopardizes modern female health, is first in women's malignant tumor.Breast carcinoma mostly occurs in 40～60 years old, the women before and after menopause.Because the direct cause of disease of breast carcinoma is not understood till now yet, the immediate cause that causes breast cancer relapse is also unclear, the recurrence that prevents breast carcinoma so also just exists certain difficulty, that is to say, people do not know that it is the recurrence how to cause, just can't prevent a certain link that it recurrence takes place or blocks its recurrence yet.However, people have found that still some and Prognosis in Breast Cancer have the factor of certain dependency, and as age, breast carcinoma clinical stages, lymphatic metastasis situation, hormone receptor situation etc., but these all are non-anthropic factor usually.
Modal first symptom of breast carcinoma is a painless property lump in the mammary gland, is that patient oneself is stumbling on mostly.10～15% lump may be with pain, lump betides breast, and to go up quadrant outward more, other quadrant is less, quality is harder, obscure boundary, lump progressively increases, and invades Ke Bai ligament (connecting the fibre bundle between body of gland and skin) and makes it to shrink, often cause that depression appears in the lump surface skin, promptly is called " dimple sign ".Lump infringement latex dust makes it to shrink and can cause crater nipple, lump continues to increase, with the extensive adhesion of skin, skin can cause edema because of the delay of lymph, because skin follicle and subcutaneous tissue adhesion are tightr, the hair follicle place forms a lot of point-like apertures when hydroderma, makes skin be " orange peel shape ".Cancerous cell forms lesser tubercle along lymph net extensive diffusive to breast and surrounding skin thereof, is called stellate ganglion.Tumor can be soaked into chest muscle and thoracic wall during late period, and is fixing, and breast also shrinks because of the infiltration of lump and is out of shape.Tumor is fused into kermesinus after extensively soaking into skin, fills the air in flakes, even can spread to back and offside skin of chest, forms by " armor sample ", can cause dyspnea, the skin ulceration forms ulcer, normal foul smelling, hemorrhage easily, or to outgrowth formation cauliflower-like tumor.It is nipple discharge that 5～10% patients' first symptom is arranged, and nipple erosion or nipple retraction is arranged.A few patients had node positive or other general before being found primary tumor blood road shifts.Cancerous cell can also directly be invaded vein and be caused metastasis, and common have bone, lung, liver etc. are located.The most common during bone shifts is spinal column, pelvis and femur, can cause pain or walking disorder; Lung shifts can cause cough, expectorant blood, breast water; Hepatic metastases can cause hepatomegaly, jaundice etc.
At present, for the treatment of mastopathy such as cyclomastopathy, domestic most employing traditional Chinese medical herbal treatment is external many with hormone preparation, vitamins etc., operative treatment in case of necessity.Chinese medicine is as ease pill, Rhizoma Cyperi ball, bazhen yimu pills, bazhen yimu wan, little gold plaque, RUZENGNING PIAN, asparagine sheet.Western medicine such as hormone medicine: tamoxifen, Ergolactin.Vitamin medicaments: vitamin E, vitamin B1, vitamin B6.But the control to breast carcinoma does not have specific drug, the purpose of this invention is to provide a kind of Chinese medicine anti-breast cancer preparation and preparation method thereof.At the characteristics of breast carcinoma, the present invention is a speciality with the foster kidney of tonifying liver, benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, and pharmaceutical composition of a kind of ideal prevention and treatment breast carcinoma and preparation method thereof is provided.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, characteristics at breast carcinoma, constitute with components such as Herba Taraxaci, Fructus Fici, the Radix Astragali, Radix Angelicae Sinensis, Radix Asparagi, Fructus Aurantii Immaturus, Radix Paeoniae Rubra, Flos Carthamis, have tonifying liver and support the effect of kidney, benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, the present invention adopts peroral dosage form, easy to use, mouthfeel is good, and cost is low, compares with similar Western medicine, its prescription is reasonable, technology is strict, have evident in efficacyly, have no side effect, the patient easily accepts, suitable advantage such as take for a long time provides a kind of pharmaceutical composition that good result is arranged to breast carcinoma prevention and treatment.Its purpose realizes by following technical proposals.
The Chinese medicine preparation of the present invention's prevention and treatment breast carcinoma is made of following component by weight percentage:
Herba Taraxaci 1～50% Fructus Fici 1～50% Radix Astragali 1～50% Radix Angelicae Sinensis 1～50%
Radix Asparagi 1～30% Fructus Aurantii Immaturus 1～20% Radix Paeoniae Rubra 1～20% Flos Carthami 1～20%
The preferable range of described each component is:
Herba Taraxaci 15～35% Fructus Ficis 15～35% Radixs Astragali 15～35% Radix Angelicae Sinensis 15～35%
Radix Asparagi 15～30% Fructus Aurantii Immaturuss 5～20% Radix Paeoniae Rubra 5～20% Flos Carthamis 5～20%.
Described each components contents is preferably:
Herba Taraxaci 20% Fructus Fici 20% Radix Astragali 20% Radix Angelicae Sinensis 20%
Radix Asparagi 5% Fructus Aurantii Immaturus 5% Radix Paeoniae Rubra 5% Flos Carthami 5%
The present invention treats the preparation method of breast carcinoma Chinese medicine preparation and takes following steps:
(1) get following raw material by weight percentage ready:
Herba Taraxaci 1～50% Fructus Fici 1～50% Radix Astragali 1～50% Radix Angelicae Sinensis 1～50%
Radix Asparagi 1～20% Fructus Aurantii Immaturus 1～20% Radix Paeoniae Rubra 1～20% Flos Carthami 1～20%
(2) Radix Angelicae Sinensis, the Flos Carthami of getting Herba Taraxaci and recipe quantity pulverized, sieved, powdering is standby;
(3) get Radix Paeoniae Rubra, Fructus Fici, Radix Asparagi, decoct with water, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby;
(4) get the Fructus Aurantii Immaturus and the Radix Astragali, add alcohol reflux, to filter, be condensed into the extractum shape standby:
(5) with the spissated two kinds of extractum mixing of above-mentioned difference, heating, add the standby Herba Taraxaci of pulverizing, Radix Angelicae Sinensis, the mixing of Flos Carthami medicated powder, drying, sieve, granulate, make suitable preparation.
Decocting number of times in the described step (3) is 2～3 times, amount of water is 6～10 times of dose, time is 1～3 hour, it is 1.15～1.35 that its water extract is concentrated into relative density, add alcoholic acid quantity, making its concentration is 50～80%, and behind the recovery ethanol, concentrated extract to relative density is 1.15～1.35; Alcohol reflux is 2～3 times in the described step (4), and alcohol adding amount is 6～10 times of dose, and the time is 1～3 hour, and behind the recovery ethanol, concentrated extract to relative density is 1.15～1.35; Described Chinese medicine preparation of the present invention is any one in tablet, granule, the capsule, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred capsule.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
In order to illustrate characteristics of the present invention better,, further specify beneficial effect of the present invention below by elaboration to pharmaceutical composition clinical observation on the therapeutic effect of the present invention.
The present invention treats the clinical observation on the therapeutic effect of the pharmaceutical composition of breast carcinoma: (seeing Table 1)
Table 1 liang group curative effect relatively
Group The example number Produce effects (%) Effectively (%) Invalid (%)
Treatment group matched group 100 100 28(28) 11(11) 68(68) 15(15) 4(4) 74(74)
The result shows that Chinese medicine preparation therapeutic effect of the present invention is better than matched group (P＜0.01).
Do not find any toxic and side effects in the observation.Prompting the present invention is a kind of more satisfactory medicine of prevention and treatment breast carcinoma.
The specific embodiment
Enumerate embodiment below, further describe the present invention, but each embodiment does not limit the present invention.
Embodiment 1:
Take by weighing Herba Taraxaci 100g, Fructus Fici 100g, Radix Astragali 100g, Radix Angelicae Sinensis 100g, Radix Asparagi 60g, Fructus Aurantii Immaturus 30g earlier, Radix Paeoniae Rubra 30g, Flos Carthami 30g are standby.With Radix Angelicae Sinensis, the Flos Carthami of Herba Taraxaci and recipe quantity pulverize, sieve, powdering is standby; Getting Radix Paeoniae Rubra, Fructus Fici, Radix Asparagi decocts with water 2 times: be the water of 8 times of amounts for the first time, 2 hours time, be the water of 6 times of amounts for the second time, the 1 hour time: collecting decoction, concentrate, add that ethanol makes its precipitation, reclaiming ethanol, to be concentrated into relative density be 1.15 extractum, standby; Getting the Fructus Aurantii Immaturus and the Radix Astragali again, with alcohol reflux 2 times, is the ethanol of 8 times of amounts for the first time, and 2 hours time was the ethanol of 6 times of amounts for the second time, 1.5 hours time: filter, reclaim ethanol, making its relative density is 1.15 extractum, standby; With twice respectively spissated extractum mixing, standby Herba Taraxaci, Radix Angelicae Sinensis, the mixing of Flos Carthami medicated powder are pulverized in adding, add 85% ethanol, and drying makes the capsule that the present invention prevented and treated breast carcinoma.
Embodiment 2
Get Herba Taraxaci 150g, Fructus Fici 150g, Radix Astragali 150g, Radix Angelicae Sinensis 150g, Radix Asparagi 100g, Fructus Aurantii Immaturus 60g, Radix Paeoniae Rubra 60g, Flos Carthami 60g are standby; With Radix Angelicae Sinensis, the Flos Carthami of Herba Taraxaci and recipe quantity pulverize, sieve, powdering is standby; Get Radix Paeoniae Rubra, Fructus Fici, Radix Asparagi, decoct with water 2 times: be the water of 8 times of amounts for the first time, 2 hours time, be the water of 10 times of amounts for the second time, the 1 hour time: collecting decoction, concentrate, add that ethanol makes its precipitation, reclaiming ethanol, to be concentrated into relative density be 1.20 extractum, standby: as to get the Fructus Aurantii Immaturus and the Radix Astragali again, with alcohol reflux 2 times, be the ethanol of 8 times of amounts for the first time, 2 hours time was the ethanol of 6 times of amounts for the second time, the 1.5 hours time: filter, reclaim ethanol, making its relative density is 1.20 extractum, standby; With twice respectively spissated extractum mixing, Radix Angelicae Sinensis, Flos Carthami medicated powder that standby Herba Taraxaci and recipe quantity are pulverized in adding mix, and add 85% ethanol, and drying makes the tablet that the present invention prevented and treated breast carcinoma.
Embodiment 3
Get Herba Taraxaci 150g, Fructus Fici 150g, Radix Astragali 150g, Radix Angelicae Sinensis 100g, Radix Asparagi 100g, Fructus Aurantii Immaturus 60g, Radix Paeoniae Rubra 60g, Flos Carthami 60g are standby; Radix Angelicae Sinensis, the Flos Carthami powder flour of Herba Taraxaci and recipe quantity is broken, sieve, powdering is standby; Get Radix Paeoniae Rubra, Fructus Fici, Radix Asparagi, decoct with water 3 times: be the water of 10 times of amounts for the first time, 2 hours time, second and third time is the water of 9 times of amounts, and the time respectively is 1 hour; Collecting decoction, concentrate, add that ethanol makes its precipitation, reclaiming ethanol, to be concentrated into relative density be 1.30 extractum, standby; Getting alcohol reflux 3 times of the Fructus Aurantii Immaturus and the Radix Astragali again, is the ethanol of 8 times of amounts for the first time, and 2 hours time, second and third time is the ethanol of 6 times of amounts, and the time respectively is 1.5 hours; Filter, reclaim ethanol, making its relative density is 1.30 extractum, standby; Twice respectively spissated extractum is mixed, and drying is sieved, and adds Radix Angelicae Sinensis, the Flos Carthami medicated powder of pulverizing standby Herba Taraxaci and recipe quantity and mixes and add 85% ethanol, and drying makes the granule of prevention of the present invention and treatment breast carcinoma.

Claims (9)

1, the pharmaceutical composition of a kind of prevention and treatment breast carcinoma, it is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials: the consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
Herba Taraxaci 1～50% Fructus Fici 1～50% Radix Astragali 1～50% Radix Angelicae Sinensis 1～50%
Radix Asparagi 1～30% Fructus Aurantii Immaturus 1～20% Radix Paeoniae Rubra 1～20% Flos Carthami 1～20%.
2, pharmaceutical composition according to claim 1 is characterized in that the formula optimization scope is:
Herba Taraxaci 15～35% Fructus Ficis 15～35% Radixs Astragali 15～35% Radix Angelicae Sinensis 15～35%
Radix Asparagi 15～30% Fructus Aurantii Immaturuss 5～20% Radix Paeoniae Rubra 5～20% Flos Carthamis 5～20%.
3, pharmaceutical composition according to claim 1, optimum weight part is:
Herba Taraxaci 20% Fructus Fici 20% Radix Astragali 20% Radix Angelicae Sinensis 20%
Radix Asparagi 5% Fructus Aurantii Immaturus 5% Radix Paeoniae Rubra 5% Flos Carthami 5%.
4, preparation of drug combination method according to claim 1 is characterized in that comprising the steps: that the Radix Angelicae Sinensis, the Flos Carthami that take by weighing each raw material Herba Taraxaci and recipe quantity by formula proportion are pulverized, sieved, powdering is standby; Get Radix Paeoniae Rubra, Fructus Fici, Radix Asparagi, decoct with water secondary, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby; Get the Fructus Aurantii Immaturus and the Radix Astragali, add the alcohol reflux secondary, to filter, be condensed into the extractum shape standby: with the spissated two kinds of extractum of above-mentioned difference mix, heating, add the standby Resina Liquidambaris of pulverizing, Exocarpium Benincasae, the mixing of Indigo Naturalis medicated powder, drying, sieve, granulate, make capsule or make any medicament on the pharmaceutics.
5, the preparation method of claim 1,2 or 3 described medicines, it comprises the following steps:
(a) take by weighing various raw material for standby such as Herba Taraxaci, Fructus Fici, the Radix Astragali, Radix Angelicae Sinensis, Radix Asparagi, Fructus Aurantii Immaturus, Radix Paeoniae Rubra, Flos Carthami.
(b) Radix Angelicae Sinensis, the Flos Carthami of getting Herba Taraxaci and recipe quantity pulverized, sieved, powdering is standby;
(c) get Radix Paeoniae Rubra, Fructus Fici, Radix Asparagi, decoct with water, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby;
(d) get the Fructus Aurantii Immaturus and the Radix Astragali, add alcohol reflux, to filter, be condensed into the extractum shape standby.
(e) the spissated two kinds of extractum of above-mentioned difference are mixed, heating, add Radix Angelicae Sinensis, the Flos Carthami medicated powder of pulverizing standby Herba Taraxaci and recipe quantity mix, dry, sieve, granulate, make suitable preparation.
6, according to the described method of claim 5 (c), wherein during extracting in water, add 8 times in water for the first time, decocted 2 hours, add 6 times in water the second time, decocted 1.5 hours.Extractum relative density after the filtrate that adds ethanol precipitation concentrates is 1.15.The time, adding amount of alcohol for the second time is 6 times, extracts 1 hour.
7, according to the described method of claim 5 (d), wherein using alcohol reflux 2 times, is the ethanol of 8 times of amounts for the first time, and 2 hours time was the ethanol of 6 times of amounts for the second time, and 1.5 hours time: filter, reclaiming the spissated extractum relative density of ethanol is 1.15.
8, pharmaceutical composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch.
9, described Chinese medicine preparation of the present invention is any one in tablet, granule, the capsule, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred capsule.
CN 200510061810 2005-12-05 2005-12-05 Medicine composition for preventing and treating breast cancer and preparing method Expired - Fee Related CN1814153B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102018736A (en) * 2010-11-19 2011-04-20 成都中医药大学 Natural indigo decoction piece and preparation method thereof
CN102273726A (en) * 2010-06-08 2011-12-14 湖北中烟工业有限责任公司 Preparation method of fig fermentation extract and application thereof to reconstituted tobacco
CN108567893A (en) * 2017-03-08 2018-09-25 洛阳士雄聚元医疗集团股份有限公司 It is a kind of to treat carcinoid oral traditional Chinese medicine composition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102273726A (en) * 2010-06-08 2011-12-14 湖北中烟工业有限责任公司 Preparation method of fig fermentation extract and application thereof to reconstituted tobacco
CN102018736A (en) * 2010-11-19 2011-04-20 成都中医药大学 Natural indigo decoction piece and preparation method thereof
CN102018736B (en) * 2010-11-19 2012-03-28 成都中医药大学 Natural indigo decoction piece and preparation method thereof
CN108567893A (en) * 2017-03-08 2018-09-25 洛阳士雄聚元医疗集团股份有限公司 It is a kind of to treat carcinoid oral traditional Chinese medicine composition

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