CN103405640B - A kind of bowel relieving preparation method of granules preoperative for Induced Labor in Late Pregnancy - Google Patents
A kind of bowel relieving preparation method of granules preoperative for Induced Labor in Late Pregnancy Download PDFInfo
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Abstract
The invention discloses a kind of bowel relieving preparation method of granules preoperative for Induced Labor in Late Pregnancy, to solve the preoperative bowel relieving problem of Induced Labor in Late Pregnancy.It is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq., Fructus cinnamomi immaturus, Radix Ranunculi Ternati, Caulis Trachelospermi, large Herba Swertiae heteranthae, Rhizoma Polygonati, Fructus Psoraleae, Pericarpium Citri Reticulatae, Flos Helianthi, Turbo cornutus Solander, Pulvis Fumi Carbonisatus, magnesium sulfate.Its preparation method comprises: (1) is by for subsequent use to Fructus Psoraleae, Fructus cinnamomi immaturus, greatly swertia coarse powder extraction volatile oil; (2) by Turbo cornutus Solander, that Pulvis Fumi Carbonisatus is ground into fine powder is for subsequent use; (3) Conyza canadensis (L.) Cronq., Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, filtrate concentrates, and adds alcohol settling, gets supernatant, reclaims ethanol and concentrates to obtain thick paste; (4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added the thick paste of step 3 gained, stir, make granule, dry, to obtain final product.Clinical trial certificate the present invention has the good feature of intestine cleaning effect for Induced Labor in Late Pregnancy is preoperative, clinic application, popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of bowel relieving preparation method of granules preoperative for Induced Labor in Late Pregnancy.
Background technology
Before Induced Labor in Late Pregnancy, INTESTINAL CLEANSING comprises stimulates enterokinesia, softening and remove feces, gets rid of enteral pneumatosis, prevents patient from increasing opportunities for contamination because anaesthetizing rear Sphincter ani chalasia and can not controlling defecation; Minimizing enteral pneumatosis fills and has feces and affects operation technique simultaneously.Clinical practice confirms, can also alleviate Post operation abdominal distention discomfort by Oral Rhubarb, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid intestinal tract cleaning.Traditional method is that art proxima luce (prox. luc) enters without slag liquid food, preoperative late oral purgative (as: mannitol), and art uses 0.2% suds cleansing enema once morning again.There is following defect in this kind of INTESTINAL CLEANSING mode: 1. mannitol is a kind of hyperosmotic dehydration agent, and intestinal stimulates strong, has a significant effect to patient's emotion, sleep state; 2. the Traditional Method last coloclysis time is art 6am in morning, and 8am enters operating room, and period does not have time enough thoroughly emptying by intestinal, easily pollutes in art; 3. beneficial effect can not be produced to post-operative recovery.
At present, also report is had to use Chinese medicine preparation to carry out preoperative intervention bowel relieving, as oral above-mentioned Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Glycyrrhizae mixing water decocting liquid, but medicine great majority used are all the purgatives medicine things such as Radix Et Rhizoma Rhei, take rear zest strong, patient's emotion, sleep state are had a significant effect, and Semen Platycladi etc. cathartic medicine is wayward rushes down the lower time.So lack now one to be applicable to preoperative intervention bowel relieving, rush down effectively lower and can not sleep be affected again, the medicine of beneficial effect can be produced for post-operative recovery.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little medicine for the preoperative intervention of Induced Labor in Late Pregnancy of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the preoperative intervention of Induced Labor in Late Pregnancy, it is characterized in that being prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 10 ~ 30 parts, Fructus cinnamomi immaturus 6 ~ 12 parts, Radix Ranunculi Ternati 3 ~ 10 parts, Caulis Trachelospermi 6 ~ 12 parts, large Herba Swertiae heteranthae 3 ~ 10 parts, Rhizoma Polygonati 6 ~ 12 parts, Fructus Psoraleae 6 ~ 12 parts, Pericarpium Citri Reticulatae 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Pulvis Fumi Carbonisatus 3 ~ 10 parts, 10 ~ 25 parts, magnesium sulfate.
Chinese medicine of the present invention can be prepared from by following method:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large swertia coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Pulvis Fumi Carbonisatus are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Conyza canadensis (L.) Cronq., Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 DEG C that filtrate is concentrated into relative density), adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added the thick paste of step 3 gained, stir, make granule, dry, to obtain final product.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Wherein said: Conyza canadensis (L.) Cronq., is Compositae Herba Erigerontis aceris platymiscium Conyza canadensis (L.) Cronq. Erigeron canadensis L., is used as medicine with herb or fresh leaf.Property mildly bitter flavor, pungent, cool.Merit can clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.
Fructus cinnamomi immaturus, the tender fruit of the children for canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.
Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.
Large Herba Swertiae heteranthae, for aristolochiaceae plant becomes mildewed the herb of Herba Asari or root, rhizome.Nature and flavor are pungent; Temperature.Merit can warming the lung to eliminate phlegm; Expelling wind and removing dampness; Regulating QI to relieve pain.
Rhizoma Polygonati is the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Merit can boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Fructus Psoraleae is the dry mature fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor are pungent, bitter, temperature.Return kidney, spleen channel.Merit can warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.Merit can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander, covers operculum for Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.Merit can clearing away damp-heat; Remove phlegm-fire; Separate sore.Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Pulvis Fumi Carbonisatus, for weeds invest the cigarette ink deposited in the bottom of a pan or chimney after burning.Nature and flavor are pungent, temperature.Merit can be stopped blooding, antidiarrheal.
Composition principle: Induced Labor in Late Pregnancy is preoperative will carry out intestinal process, namely bowel relieving.Traditional method is that art proxima luce (prox. luc) enters without slag liquid food, preoperative late oral purgative (as: mannitol or Chinese medicine cathartic prescription), and art morning, 0.2% suds (or normal saline) cleansing enema was once again.There is following defect in this kind of INTESTINAL CLEANSING mode: 1. mannitol or Chinese medicine cathartic prescription, and intestinal stimulates strong, has a significant effect to patient's emotion, sleep state; 2. the Traditional Method last coloclysis time is art 6am in morning, and 8am enters operating room, and period does not have time enough thoroughly emptying by intestinal, easily pollutes in art; 3. beneficial effect can not be produced to post-operative recovery.We are cathartic with magnesium sulfate, coordinate the medicine of fugitive stable enterokinesia, and the reaction sensitivity that suitable reduction intestinal contents stimulates intestinal, lax intestinal smooth.Like this, the magnesium sulfate entering intestinal on the one hand not easily absorbs at intestinal, forms hyperosmotic state, completes catharsis effect; On the other hand the medicine of fugitive stable enterokinesia relaxes intestinal smooth, alleviates awareness of defecation, to ensure Sleeping.Meanwhile, other pharmaceutical components in we complete invigorate blood circulation, eliminate the phlegm, the effect of eliminating stagnation, dredging collateral, promote Induced Labor in Late Pregnancy post-operative recovery.
Compared with prior art, the present invention has following characteristics.
1, Conyza canadensis (L.) Cronq. and Fructus cinnamomi immaturus coordinate for monarch drug, inventor studies discovery: the mixing water decocting liquid of Conyza canadensis (L.) Cronq. and Fructus cinnamomi immaturus is wriggled without obvious inhibitory action to isolated mouse ileum, but when gastrointestinal smooth muscle is in the excitatory state under magnesium sulfate stimulation, there is remarkable relexation.Its mechanism of action may be relevant to the smooth muscle relaxation of Conyza canadensis (L.) Cronq. total flavones water soluble part, but this kind of effect coordinates can only come into force for the intestinal wall smooth muscle under excited state with Fructus cinnamomi immaturus.Under this dosage, the pharmacological action time of Conyza canadensis (L.) Cronq. is 8 ~ 10 hours, namely takes medicine night, can alleviate the awareness of defecation under magnesium sulfate stimulation, and ensure suitable sleep, after art drug effect in morning is lost, can complete the effect of cleaning intestinal.
2, Radix Ranunculi Ternati mass dissipating and swelling eliminating, Caulis Trachelospermi dredging collateral reducing swelling and alleviating pain, alleviates the discomfort that postoperative pelvic cavity excitation causes.
3, Rhizoma Polygonati boosting qi and nourishing yin, Fructus Psoraleae nourishing the liver and kidney, Pericarpium Citri Reticulatae invigorating the spleen and benefiting QI diuretic, the postoperative function of intestinal canal that is conducive to recovers, and shortens fasting time, is conducive to early recovery.
4, large Herba Swertiae heteranthae is invigorated blood circulation motionless blood, and has the strong muscle effect of dredging collateral.
5, inventor's experimentation shows: low dose of Turbo cornutus Solander can stablize intestinal mucosa effectively.
6, Flos Helianthi is using corrigent, and this medicine obviously can strengthen intestinal contraction, and lasting medicine, utilize low dose of Flos Helianthi to prevent Conyza canadensis (L.) Cronq. overaction.
7, in one row falls apart dredging collateral medicine, add low dose of Pulvis Fumi Carbonisatus, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
9, bead dosage form is adopted, easy to use.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Radix Ranunculi Ternati 6 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 6 parts, Rhizoma Polygonati 10 parts, Fructus Psoraleae 10 parts, Pericarpium Citri Reticulatae 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Pulvis Fumi Carbonisatus 6 parts, 20 parts, magnesium sulfate.
The preparation method of embodiment 1 is: Conyza canadensis (L.) Cronq., Fructus cinnamomi immaturus, Radix Ranunculi Ternati, Caulis Trachelospermi, large Herba Swertiae heteranthae, Rhizoma Polygonati, Fructus Psoraleae, Pericarpium Citri Reticulatae, Flos Helianthi, Turbo cornutus Solander, Pulvis Fumi Carbonisatus, magnesium sulfate mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate is merged into decoction.
Embodiment 2, crude drug weight proportion: Conyza canadensis (L.) Cronq. 10 parts, Fructus cinnamomi immaturus 6 parts, Radix Ranunculi Ternati 3 parts, Caulis Trachelospermi 6 parts, large Herba Swertiae heteranthae 3 parts, Rhizoma Polygonati 6 parts, Fructus Psoraleae 6 parts, Pericarpium Citri Reticulatae 6 parts, Flos Helianthi 6 parts, Turbo cornutus Solander 1 part, Pulvis Fumi Carbonisatus 3 parts, 10 parts, magnesium sulfate.
Embodiment 3, crude drug weight proportion: Conyza canadensis (L.) Cronq. 20 parts, Fructus cinnamomi immaturus 10 parts, Radix Ranunculi Ternati 6 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 6 parts, Rhizoma Polygonati 10 parts, Fructus Psoraleae 10 parts, Pericarpium Citri Reticulatae 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Pulvis Fumi Carbonisatus 6 parts, 20 parts, magnesium sulfate.
Embodiment 4, crude drug weight proportion: Conyza canadensis (L.) Cronq. 30 parts, Fructus cinnamomi immaturus 12 parts, Radix Ranunculi Ternati 10 parts, Caulis Trachelospermi 12 parts, large Herba Swertiae heteranthae 10 parts, Rhizoma Polygonati 12 parts, Fructus Psoraleae 12 parts, Pericarpium Citri Reticulatae 12 parts, Flos Helianthi 12 parts, Turbo cornutus Solander 5 parts, Pulvis Fumi Carbonisatus 10 parts, 25 parts, magnesium sulfate.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large swertia coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Pulvis Fumi Carbonisatus are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Conyza canadensis (L.) Cronq., Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 DEG C that filtrate is concentrated into relative density), adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added the thick paste of step 3 gained, stir, make granule, dry, to obtain final product.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Described magnesium sulfate can be magnesium sulfate powder, also can be Adlerika.
The efficient combination of said medicine, coordinates mutually, effectively reaches the object of the preoperative cleaning intestinal of Induced Labor in Late Pregnancy, and does not affect Sleeping, be beneficial to post-operative recovery.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: the Induced Labor in Late Pregnancy that in March, 2012 ~ 2013 are accepted for medical treatment year April is chosen date for operation and needed cleansing enema patient 81 example, and pregnant week is between 28 ~ 37 weeks.
1.1.2 divide into groups: be divided into matched group 27 example at random, at 19 ~ 42 years old age, the mean age is 27.3 years old.Decoction group 27 example, 17 ~ 39 years old age, 25.4 years old mean age.Groups of grains 27 example, 18 ~ 41 years old age, 24.6 years old mean age.Compare in age, pregnant week, mean operative time before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 administering mode: all case art proxima luce (prox. luc)s enter without slag liquid food, and matched group takes conventional method of clyster: preoperative late oral mannitol, art morning, normal saline cleansing enema was once again.Decoction group preoperative late 8 time adopt embodiment 1 gained decoction oral, art normal saline in morning cleansing enema is once.Groups of grains preoperative late 8 time adopt embodiment 3 gained particulate oral, art normal saline in morning cleansing enema is once.
1.2.2 observation index: after bowel relieving operation, observe patient's defecation frequency, intestinal tract cleaning and pneumatosis situation in record art, and micturition time after operation in patients and untoward reaction are passed judgment on.
1.2.3 intestine cleaning effect evaluation criterion: be effectively intestinal in operation in patients and keep complete relaxed state, pollute without leakage in art; Invalidly be intestinal high level expansion in operation in patients, in art, occur that leakage is polluted.
2 results.
Intestinal tract cleaning situation and transfusion definition situation in 2.1 arts: the effective percentage of matched group, decoction group, groups of grains bowel relieving is 100%.
Between 2.2 3 groups of operation in patients eve, defecation, art defecation in morning situation, insomnia situation postoperative bowel situation saw the following form:
| Group | Number of cases | Defecation at night (secondary) | Art defecation in morning (secondary) | Insomnia (example) | Postoperative bowel (h) |
| Matched group | 27 | 2. 62±0.23 | 2.25±0.32 | 19 | 36.13±11.61 |
| Decoction group | 27 | 0.95±0.22 | 5.72±0.37 | 8 | 25.24±4.62 |
| Groups of grains | 27 | 0. 96±0.44 | 4.73±0.26 | 6 | 24.21±5.38 |
Result shows: apply decoction of the present invention or bead dosage form preoperative night orally can reduce defecation frequency at night, increases art defecation in morning, reduces the generation of having a sleepless night, reach postoperative bowel as early as possible, and compare with matched group (P<0.05).
Before 2.3 3 groups of operation in patients, nursing intervention satisfaction compares: matched group patient is 86.67% to preoperative nursing intervention satisfaction, and the satisfaction of decoction group, groups of grains bowel relieving is 100%.
3. conclusion.
This result of study shows, and the preoperative oral decoction of the present invention or granule intestine cleaning effect obviously, can effectively reduce defecation frequency at night, increase art defecation in morning, reduce the generation of insomnia, reach postoperative bowel as early as possible, increases patient to the satisfaction of nursery work.
Claims (2)
1. one kind for the preoperative bowel relieving preparation method of granules of Induced Labor in Late Pregnancy, it is characterized in that, be prepared from by the crude drug of following weight proportion: Conyza canadensis (L.) Cronq. 10 ~ 30 parts, Fructus cinnamomi immaturus 6 ~ 12 parts, Radix Ranunculi Ternati 3 ~ 10 parts, Caulis Trachelospermi 6 ~ 12 parts, large Herba Swertiae heteranthae 3 ~ 10 parts, Rhizoma Polygonati 6 ~ 12 parts, Fructus Psoraleae 6 ~ 12 parts, Pericarpium Citri Reticulatae 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Pulvis Fumi Carbonisatus 3 ~ 10 parts, 10 ~ 25 parts, magnesium sulfate, be made up of following steps:
(1) Fructus Psoraleae, Fructus cinnamomi immaturus, large swertia coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Pulvis Fumi Carbonisatus are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Conyza canadensis (L.) Cronq., Radix Ranunculi Ternati, Caulis Trachelospermi, Rhizoma Polygonati, Flos Helianthi, Pericarpium Citri Reticulatae are decocted with water 2 times, filter, merging filtrate, at filtrate is concentrated into 50 DEG C, relative density is 1.20, adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) volatile oil of step 1 gained, the fine powder of step 2 gained, magnesium sulfate are added the thick paste of step 3 gained, stir, make granule, dry, to obtain final product.
2. a kind of bowel relieving preparation method of granules preoperative for Induced Labor in Late Pregnancy according to claim 1, is characterized in that: the simmer down to concentrating under reduced pressure described in described step (3).
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| CN1123687A (en) * | 1994-12-30 | 1996-06-05 | 程树杰 | Curing chronic habitual diarrhea specially |
| CN1341430A (en) * | 2001-06-05 | 2002-03-27 | 叶松胜 | Medicine for relaxing bowels |
| US6946149B2 (en) * | 2002-04-30 | 2005-09-20 | Braintree Laboratories, Inc. | Salt solution for colon cleansing |
| CN102114042A (en) * | 2009-12-30 | 2011-07-06 | 宋杰 | Intestinal tract cleaning solution specially used for preoperation of children with hirschsprung disease |
| WO2012138076A2 (en) * | 2011-04-04 | 2012-10-11 | Jeong Pil Gu | Composition containing herbal extract mixture for prevention or treatment of gastrointestinal diseases |
| CN103142897B (en) * | 2013-03-31 | 2014-07-02 | 张朋飞 | Medicine used after esophageal achalasia operation |
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Address after: 261400 Laizhou Yantai people's Hospital, 1817 east culture street, Laizhou, Shandong, Shandong Applicant after: Jiang Chunjie Address before: 261400 Department of Neurology, Laizhou people's Hospital of Laizhou, Shandong Province, Shandong 1817, Yantai Applicant before: Jiang Chunjie |
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